{% load static %}
<!-- RECEPTORS -->
<li class="dropdown gpcr {% if current_site == 'gpcr' %}highlight_menu{% endif %}" id="gpcrdb_menu">
<a tabindex="0" href="{{ hosts.gpcr }}/" class="dropdown-toggle" data-toggle="dropdown" role="button" data-submenu aria-expanded="false">
GPCRdb<span class="caret"></span>
</a>
<ul class="dropdown-menu" role="menu">
<li><a href="{{ hosts.gpcr }}/protein">Receptor page
<button mp4="https://files.gpcrdb.org/video/receptors1.mp4"
class="videoLink pull-right btn btn-xs btn-default">
<span class="glyphicon glyphicon-film"></span>
</button>
</a></li>
<!-- SEQUENCES -->
<li class="divider"></li>
<li class="nav-header disabled text-left"><a>SEQUENCES</a></li>
<li>
<a href="{{ hosts.gpcr }}/alignment/targetselection">Sequence alignments
<button mp4="https://files.gpcrdb.org/video/sequences1.mp4" type="button"
class="videoLink pull-right btn btn-xs btn-default">
<span class="glyphicon glyphicon-film"></span>
</button>
</a>
</li>
<li><a href="{{ hosts.gpcr }}/residue/residuetable">Generic residue number tables</a></li>
<li class="dropdown-submenu">
<a tabindex="0" href="#">Genetic variants</a>
<ul class="dropdown-menu">
<li><a href="{{ hosts.gpcr }}/mutational_landscape/statistics">Variation statistics</a></li>
<li><a href="{{ hosts.gpcr }}/mutational_landscape">Receptor variants</a></li>
<li><a href="{{ hosts.gpcr }}/mutational_landscape/economicburden">Estimated economic burden</a></li>
</ul>
</li>
<li><a href="{{ hosts.gpcr }}/protein/isoforms">Isoforms</a></li>
<!-- SEQUENCE COMPARISON -->
<li class="divider"></li>
<li class="nav-header disabled text-left"><a>SEQUENCE COMPARISON</a></li>
<li class="dropdown-submenu">
<a tabindex="0" href="#">Receptor similarity</a>
<ul class="dropdown-menu">
<li><a href="{{ hosts.gpcr }}/similaritysearch/referenceselection">BLAST (GPCRdb alignment)
<button mp4="https://files.gpcrdb.org/video/sequences2.mp4" type="button"
class="videoLink pull-right btn btn-xs btn-default">
<span class="glyphicon glyphicon-film"></span>
</button>
</a></li>
<li><a href="{{ hosts.gpcr }}/alignment/blastsearch">BLAST (non-GPCRdb query)</a></li>
<li><a href="{{ hosts.gpcr }}/phylogenetic_trees/targetselection">Phylogenetic trees</a></li>
<li><a href="{{ hosts.gpcr }}/similaritymatrix/targetselection">Similarity matrix (all-to-all)</a></li>
</ul>
</li>
<li><a href="{{ hosts.gpcr }}/sitesearch/targetselection">Site search (by seq. motif)</a></li>
<!-- STRUCTURES -->
<li class="divider"></li>
<li class="nav-header disabled text-left"><a>STRUCTURES</a></li>
<li><a href="{{ hosts.gpcr }}/structure/statistics">Structure statistics
<button mp4="https://files.gpcrdb.org/video/structures1.mp4" type="button"
class="videoLink pull-right btn btn-xs btn-default">
<span class="glyphicon glyphicon-film"></span>
</button>
</a></li>
<li><a href="{{ hosts.gpcr }}/structure">Structures</a></li>
<li><a href="{{ hosts.gpcr }}/structure/homology_models">Structure models</a></li>
<li><a href="{{ hosts.gpcr }}/structure/model_statistics">Structure model statistics</a></li>
{# DEPRECATED FOR NOW #}
{# <li><a href="{{ hosts.gpcr }}/structure/template_selection">Template selection</a></li> #}
<!-- STRUCTURE COMPARISON -->
<li class="divider"></li>
<li class="nav-header disabled text-left"><a>STRUCTURE COMPARISON</a></li>
<li><a href="{{ hosts.gpcr }}/structure_comparison/comparative_analysis">Structure comparison tool</a></li>
<li><a href="{{ hosts.gpcr }}/structure_comparison/structure_clustering">Structure similarity trees</a></li>
<li><a href="{{ hosts.gpcr }}/structure/superposition_workflow_index/true">Structure superposition</a></li>
{# NOTE: we need the spacing here to keep all elements including icons in a single line #}
<li><a href="{{ hosts.gpcr }}/structure/generic_numbering_index">Generic residue numbering (PDB) </a></li>
<!-- DETERMINANTS & MUTATIONS -->
<li class="divider"></li>
<li class="nav-header disabled text-left"><a>DETERMINANTS & MUTATIONS</a></li>
<li><a href="{{ hosts.gpcr }}/seqsign">Sequence signature tool</a></li>
<li><a href="{{ hosts.gpcr }}/mutations/state_stabilizing">State-affecting mutation design</a></li>
</ul>
</li>
<!-- DRUGS -->
{% comment %}
<li class="dropdown">
<a href="/" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false">
Drugs<span class="caret"></span>
</a>
<ul class="dropdown-menu" role="menu">
<li class="nav-header disabled"><a>DATA</a></li>
<li><a href="{{ hosts.gpcr }}/drugs/drugstatistics">Drug statistics</a></li>
<li><a href="{{ hosts.gpcr }}/drugs/drugmapping">Drug target mapping</a></li>
<li><a href="{{ hosts.gpcr }}/drugs/drugbrowser">Drug browser</a></li>
</ul>
</li>
{% endcomment %}
<!-- DRUGS AND LIGANDS -->
<li class="dropdown gpcr {% if current_site == 'gpcr' %}highlight_menu {{current_site}}{% endif %}" id="drugs_menu">
<a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-submenu aria-expanded="false">
Drugs <span>&</span> ligands<span class="caret"></span>
</a>
<ul class="dropdown-menu" role="menu">
<li class="nav-header disabled"><a>ENDOGENOUS LIGANDS</a></li>
<li><a href="{{ hosts.gpcr }}/ligand/endogenous">Endogenous ligands (GtP)</a></li>
<li class="divider"></li>
<li class="nav-header disabled"><a>DRUGS & AGENTS IN TRIAL</a></li>
<li><a href="{{ hosts.gpcr }}/drugs/drugbrowser">Drugs, targets <span>&</span> indications</a></li>
<li><a href="{{ hosts.gpcr }}/drugs/drugmapping">Drug target tree</a></li>
<li><a href="{{ hosts.gpcr }}/drugs/drugstatistics">Drug statistics</a></li>
<li class="divider"></li>
<li class="nav-header disabled"><a>LIGANDS</a></li>
<li><a href="{{ hosts.gpcr }}/ligand/statistics">Ligand statistics</a></li>
<li><a href="{{ hosts.gpcr }}/ligand">Ligands (ChEMBL)</a></li>
<!-- DEPRECATED FUNCTION
<li class="nav-header disabled text-left"><a>Structures</a></li>
<li>
<a href="/structure/fragment_superposition_index">
Pharmacophore generation
<button url='https://dx.doi.org/10.1016/j.ymeth.2014.09.009'
class="refLink pull-right btn btn-xs btn-default"
data-toggle="tooltip" data-placement="right" title="Methods">
<span class="glyphicon glyphicon-book"></span>
</button>
</a></li>
-->
<li class="divider"></li>
<li class="nav-header disabled text-left"><a>LIGAND SITES</a></li>
<li><a href="{{ hosts.gpcr }}/interaction">GPCR-ligand interactions
<button mp4="https://files.gpcrdb.org/video/interactions1.mp4" type="button"
class="videoLink pull-right btn btn-xs btn-default">
<span class="glyphicon glyphicon-film"></span>
</button>
</a></li>
<li><a href="{{ hosts.gpcr }}/sitesearch/targetselection">Site search (by seq. motif) </a></li>
<li><a href="{{ hosts.gpcr }}/sitesearch/targetselectionpdb">Site search (by ligand complex)
<button mp4="https://files.gpcrdb.org/video/interactions2.mp4" type="button"
class="videoLink pull-right btn btn-xs btn-default">
<span class="glyphicon glyphicon-film"></span>
</button>
</a></li>
<!-- MUTATIONS -->
<li class="divider"></li>
<li class="nav-header disabled text-left"><a>LIGAND SITE MUTATIONS</a></li>
<li><a href="{{ hosts.gpcr }}/mutations/statistics">Mutation statistics</a></li>
<li><a href="{{ hosts.gpcr }}/mutations">Mutations
<button mp4="https://files.gpcrdb.org/video/mutations1.mp4" type="button"
class="videoLink pull-right btn btn-xs btn-default">
<span class="glyphicon glyphicon-film"></span>
</button>
</a></li>
<li class="dropdown-submenu">
<a tabindex="0" href="#">Mutation design tool</a>
<ul class="dropdown-menu">
<li><a href="{{ hosts.gpcr }}/mutations/design">By receptor name</a></li>
<li><a href="{{ hosts.gpcr }}/mutations/designpdb">By PDB id</a></li>
</ul>
</li>
<li><a href="{{ documentation_url }}mutations.html#mutation-data-submission">Mutation data submission</a></li>
</ul>
</li>
<!-- STRUCTURE CONSTRUCTS -->
<li class="dropdown gpcr {% if current_site == 'gpcr' %}highlight_menu {{current_site}}{% endif %}" id="constructs_menu">
<a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-expanded="false">
Structure constructs<span class="caret"></span>
</a>
<ul class="dropdown-menu" role="menu">
<li class="nav-header disabled text-left"><a>Construct & experiment design</a></li>
<li><a href="{{ hosts.gpcr }}/construct">Construct alignments</a></li>
<li><a href="{{ hosts.gpcr }}/construct/design">Construct design tool
<button mp4="https://files.gpcrdb.org/video/constructtool3.mp4" type="button"
class="videoLink pull-right btn btn-xs btn-default">
<span class="glyphicon glyphicon-film"></span>
</button>
</a></li>
<li><a href="{{ hosts.gpcr }}/construct/experiments">Experiment browser</a></li>
<li class="divider"></li>
<li class="nav-header disabled text-left"><a>Truncation & fusion analysis</a></li>
<li><a href="{{ hosts.gpcr }}/construct/analysis#truncations">Truncation sites</a></li>
<li><a href="{{ hosts.gpcr }}/construct/analysis#fusions">Fusion sites</a></li>
<li><a href="{{ hosts.gpcr }}/construct/analysis#loopdeletions">Loop deletions</a></li>
<li class="divider"></li>
<li class="nav-header disabled text-left"><a>Mutation analysis</a></li>
<li><a href="{{ hosts.gpcr }}/construct/mutations">Stabilising mutations</a></li>
<li><a href="{{ hosts.gpcr }}/construct/stabilisation">StabMutAnalyser</a></li>
<li><a href="{{ hosts.gpcr }}/construct/analysis#mutations">Mutation substitution matrix</a></li>
</ul>
</li>
<!-- BIASED SIGNALING -->
<li class="dropdown gpcr {% if current_site == 'gpcr' %}highlight_menu {{current_site}}{% endif %}" id="biased_menu">
<a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" data-submenu aria-expanded="false">
Biased signalling<span class="caret"></span>
</a>
<ul class="dropdown-menu" role="menu">
<li class="dropdown-submenu guidelines">
<a tabindex="0" href="#">Guidelines</a>
<ul class="dropdown-menu">
<li><a href="{{ hosts.gpcr }}/biased_signalling/bias_guidelines">Guideline paper</a></li>
<li><a href="https://files.gpcrdb.org/bias_guidelines/Template_to_calculate_ligand_bias_factors.xlsx">Template to calculate ligand bias factors (MS Excel)</a></li>
</ul>
</li>
<li class="divider"></li>
<li class="nav-header disabled"><a>BIASED LIGANDS (effector family)</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/bias_statistics">Biased ligand statistics</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/biasedbrowser">Biased ligands (∆∆log(Emax/EC50) & ∆∆log(Tau/KA)</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/emax_rank_order_selection">Ligand bias rank orders (ΔΔlog(Emax/EC50))</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/tau_rank_order_selection">Ligand bias rank orders (ΔΔlog(Tau/KA))</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/emax_path_profiles_selection">Ligand pathway profiles (Δlog(Emax/EC50))</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/tau_path_profiles_selection">Ligand pathway profiles (Δlog(Tau/KA))</a></li>
<li class="divider"></li>
<li class="nav-header disabled"><a>PATHWAY-PREFERRING LIGANDS (effector family)</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/path_preference_statistics">Pathway-preferring ligand statistics</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/biasedpredictedbrowser">Pathway-preferring ligands (pathway ∆Log/(Emax/EC50)</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/path_preference_emax_rankorder_selection">Ligand pathway preference rank orders (Δlog(Emax/EC50))</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/path_preference_emax_path_profiles_selection">Ligand pathway profiles (Log(Emax/EC50))</a></li>
<li class="divider"></li>
<li class="nav-header disabled"><a>BIASED LIGANDS (subtype)</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/subtype_statistics">Biased ligand statistics</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/biasedsubtypesbrowser">Biased ligands (subtype ∆∆log(Emax/EC50) & ∆∆log(Tau/KA)</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/subtype_emax_rankorder_selection">Ligand bias rank orders (ΔΔlog(Emax/EC50))</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/subtype_tau_rank_order_selection">Ligand bias rank orders (ΔΔlog(Tau/KA))</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/subtype_emax_path_profiles_selection">Ligand pathway profiles (Δlog(Emax/EC50))</a></li>
<li><a href="https://test.gpcrdb.org/biased_signalling/subtype_tau_path_profiles_selection">Ligand pathway profiles (Δlog(Tau/KA))</a></li>
<li class="divider"></li>
<li class="nav-header disabled text-left"><a>Pathways</a></li>
<li><a href="{{ hosts.gpcr }}/biased_signalling/biasedpathways">Pathway effects</a></li>
<li class="divider"></li>
<li class="nav-header disabled"><a>DATA DEPOSITION</a></li>
<li><a href="{{ documentation_url }}biasedsignaling.html#data-submission">Data submission</a></li>
</ul>
</li>