aripiprazole lauroxil


SMILES CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=CC=C(OCCCCN3CCN(CC3)C3=C(Cl)C(Cl)=CC=C3)C=C12
InChIKey DDINXHAORAAYAD-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 19
Molecular weight (Da) 659.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.06 8.06 8.06 Drug Central
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.07 8.07 8.07 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.13 8.13 8.13 Drug Central
D2 DRD2 Human Dopamine A pKi 8.02 8.02 8.02 Drug Central
D3 DRD3 Human Dopamine A pKi 8.04 8.04 8.04 Drug Central
H1 HRH1 Human Histamine A pKi 8.14 8.14 8.14 Drug Central
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
D4 DRD4 Rat Dopamine A pKi 8.14 8.14 8.14 Drug Central
D2 DRD2 Rat Dopamine A pKi 8.01 8.01 8.01 Drug Central
D4 DRD4 Human Dopamine A pKi 8.13 8.13 8.13 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database