CHEMBL225589
| SMILES | CN(C)c1ccnc2sc3c(=O)n(-c4ccc(Cl)cc4)cnc3c12 |
| InChIKey | PCDABTQQAJSLPA-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 6 |
| Hydrogen bond donors | 0 |
| Rotatable bonds | 2 |
| Molecular weight (Da) | 356.1 |
Drug properties
| Molecular type | Small molecule |
| Endogenous/Surrogate | Surrogate |
| Approved drug | No |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| mGlu1 | GRM1 | Rat | Metabotropic glutamate | C | pKi | 8.4 | 8.4 | 8.4 | ChEMBL |
| mGlu5 | GRM5 | Rat | Metabotropic glutamate | C | pKi | 5.99 | 5.99 | 5.99 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| mGlu1 | GRM1 | Rat | Metabotropic glutamate | C | pIC50 | 7.8 | 7.8 | 7.8 | ChEMBL |
| mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pIC50 | 5.74 | 5.74 | 5.74 | ChEMBL |
| mGlu1 | GRM1 | Human | Metabotropic glutamate | C | pIC50 | 7.8 | 7.8 | 7.8 | ChEMBL |