CHEMBL223496


SMILES Cc1ccc(-n2cnc3c(sc4nccc(N(C)C)c43)c2=O)cc1
InChIKey TUKBLRJBXIQJPU-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 336.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Sankey plot

Compound is not listed as a drug.

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 8.7 8.7 8.7 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 6.3 6.3 6.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 8.3 8.3 8.3 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 8.3 8.3 8.3 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 6.05 6.05 6.05 ChEMBL