SELECT A RECEPTOR in the table and click a green button

The next page shows ligands biased for a transducer or effector family (e.g. G protein, arrestin, GRK, ERK etc.).
Physiology-bias, pathway-bias and benchmark-bias is explained in the article Community Guidelines for GPCR Ligand Bias.
*Biased ligands have a bias factor ≥ 5.

  Receptor classification Number of ligands


Class
 		 Ligand type
 		 Family
 		 Species
 		 Receptor
(UniProt)		 Receptor
(GtP)		 Tested
(total)		 Balanced
references		 Pathway
biased *		 Physiology
biased *
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT1A 5-HT1A 24 1 - 20
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT1B 5-HT1B 12 - - 9
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT2A 5-HT2A 11 - - -
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT2B 5-HT2B 20 1 1 10
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT2C 5-HT2C 32 2 3 18
A Aminergic 5-Hydroxytryptamine Homo sapiens 5HT7R 5-HT7 6 - - -
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM1 M1 14 - - 1
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM2 M2 22 - - 4
A Aminergic Dopamine Homo sapiens DRD2 D2 319 3 18 40
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM3 M3 8 - - 2
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM4 M4 5 - - -
A Aminergic Acetylcholine (muscarinic) Homo sapiens ACM5 M5 5 1 2 -
A Aminergic Adrenoceptors Homo sapiens ADA1A α1A-adrenoceptor 8 - - 4
A Aminergic Adrenoceptors Homo sapiens ADA2C α2C-adrenoceptor 8 - - 2
A Aminergic Adrenoceptors Homo sapiens ADRB1 β1-adrenoceptor 25 1 - 5
A Aminergic Adrenoceptors Homo sapiens ADRB2 β2-adrenoceptor 67 2 - 28
A Aminergic Dopamine Homo sapiens DRD1 D1 129 2 - 9
A Aminergic Dopamine Homo sapiens DRD3 D3 28 - - -
A Aminergic Dopamine Homo sapiens DRD5 D5 6 - - 5
A Aminergic Histamine Homo sapiens HRH3 H3 5 1 - -
A Aminergic Histamine Homo sapiens HRH4 H4 31 - - 9
A Peptide Angiotensin Homo sapiens AGTR1 AT1 27 3 2 16
A Peptide Apelin Homo sapiens APJ apelin 54 3 3 3
A Peptide Complement peptide Homo sapiens C5AR1 C5a1 2 - - -
A Peptide Endothelin Homo sapiens EDNRA ETA 4 - - 3
A Peptide Formylpeptide Homo sapiens FPR1 FPR1 13 - - 8
A Peptide Formylpeptide Homo sapiens FPR2 FPR2/ALX 6 1 - -
A Peptide Galanin Homo sapiens GALR2 GAL2 3 - - 2
A Peptide Ghrelin Homo sapiens GHSR ghrelin 17 2 - -
A Peptide Melanocortin Homo sapiens MSHR MC1 4 - - -
A Peptide Melanocortin Homo sapiens MC3R MC3 4 - - -
A Peptide Melanocortin Homo sapiens MC4R MC4 4 1 1 -
A Peptide Melanocortin Homo sapiens MC5R MC5 4 - - -
A Peptide Neuropeptide S Homo sapiens NPSR1 NPS 6 - - -
A Peptide Neuropeptide Y Homo sapiens NPY1R Y1 4 - - -
A Peptide Opioid Homo sapiens OPRD δ 82 3 19 34
A Peptide Opioid Homo sapiens OPRK κ 123 3 1 30
A Peptide Opioid Homo sapiens OPRM μ 310 6 7 40
A Peptide Opioid Homo sapiens OPRX NOP 28 - - 17
A Peptide Proteinase-activated Homo sapiens PAR2 PAR2 2 - - -
A Peptide Relaxin family peptide Homo sapiens RXFP1 RXFP1 2 - - -
A Peptide Vasopressin and oxytocin Homo sapiens V1AR V1A 2 - - 1
A Peptide Vasopressin and oxytocin Homo sapiens V1BR V1B 2 - - -
A Peptide Vasopressin and oxytocin Homo sapiens V2R V2 2 - - 1
A Peptide Vasopressin and oxytocin Homo sapiens OXYR OT 2 - - -
A Protein Chemokine Homo sapiens CCR1 CCR1 11 3 7 4
A Protein Chemokine Homo sapiens CCR2 CCR2 3 - - 1
A Protein Chemokine Homo sapiens CCR5 CCR5 7 - - 3
A Protein Chemokine Homo sapiens CCR10 CCR10 2 - - 1
A Protein Chemokine Homo sapiens CXCR1 CXCR1 3 - - -
A Protein Chemokine Homo sapiens CXCR2 CXCR2 6 - - 1
A Protein Chemokine Homo sapiens CXCR3 CXCR3 33 2 - 2
A Protein Chemokine Homo sapiens CXCR4 CXCR4 2 - - -
A Protein Glycoprotein hormone Homo sapiens LSHR LH 4 - - 2
A Lipid Free fatty acid Homo sapiens FFAR1 FFA1 9 - - 3
A Lipid Lysophospholipid (LPA) Homo sapiens LPAR1 LPA1 10 - - -
A Lipid Lysophospholipid (S1P) Homo sapiens S1PR1 S1P1 2 1 1 -
A Lipid Cannabinoid Homo sapiens CNR1 CB1 48 2 4 6
A Lipid Cannabinoid Homo sapiens CNR2 CB2 46 2 5 28
A Lipid Prostanoid Homo sapiens PE2R2 EP2 39 - - 7
A Lipid Prostanoid Homo sapiens PE2R4 EP4 11 - - -
A Nucleotide Adenosine Homo sapiens AA1R A1 34 2 - -
A Nucleotide Adenosine Homo sapiens AA2BR A2B 11 - - 6
A Nucleotide Adenosine Homo sapiens AA3R A3 55 3 15 16
A Orphan A orphans Homo sapiens GPR84 GPR84 77 2 21 -
B1 Peptide Calcitonin Homo sapiens CALCR CT 8 1 - 2
B1 Peptide Calcitonin Homo sapiens CALRL calcitonin -like 19 1 - -
B1 Peptide Glucagon Homo sapiens GLP1R GLP-1 60 1 - 2
B1 Peptide Glucagon Homo sapiens GLR glucagon 1 - - -
A Lipid Cannabinoid Mus musculus CNR2 CB2 39 1 21 -
A Peptide Opioid Rattus norvegicus OPRM μ 24 - - 12
A Peptide Opioid Mus musculus OPRK κ 43 - - 7
B1 Peptide Glucagon Mus musculus GLP1R GLP-1 7 - - -
A Peptide Opioid Mus musculus OPRD δ 42 - - 4
A Aminergic Dopamine Mus musculus DRD2 D2 21 - - -
A Nucleotide Adenosine Mus musculus AA2BR A2B 8 - - -
C Ion Calcium-sensing Rattus norvegicus CASR CaS 10 1 - -
B1 Peptide Glucagon Rattus norvegicus GLP1R GLP-1 17 - - -
A Peptide Opioid Mus musculus OPRM μ 43 - - -
A Peptide Opioid Canis lupus familiaris A0A0F6TMT6 μ 1 - - -