GPCRdb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	2274	3173	None	38	Human	Functional	pAC50	=	5	5.0	-724	36	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3173	None	38	Human	Functional	pAC50	=	5	5.0	-724	36	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917.0	3173	None	38	Human	Functional	pAC50	=	5	5.0	-724	36	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3173	None	38	Human	Functional	pAC50	=	5	5.0	-724	36	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3173	None	38	Human	Functional	pAC50	=	5	5.0	-724	36	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3173	None	38	Human	Functional	pAC50	=	5	5.0	-724	36	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2600	3779	None	53	Human	Functional	pAC50	=	5	5.0	-389	32	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3779	None	53	Human	Functional	pAC50	=	5	5.0	-389	32	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3779	None	53	Human	Functional	pAC50	=	5	5.0	-389	32	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3779	None	53	Human	Functional	pAC50	=	5	5.0	-389	32	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3779	None	53	Human	Functional	pAC50	=	5	5.0	-389	32	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2520	206466	None	47	Human	Functional	pAC50	=	5	5.0	-26	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1280	206466	None	47	Human	Functional	pAC50	=	5	5.0	-26	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL6966	206466	None	47	Human	Functional	pAC50	=	5	5.0	-26	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	72093	35070	None	5	Human	Functional	pAC50	=	5.0	5.0	-10	28	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35070	None	5	Human	Functional	pAC50	=	5.0	5.0	-10	28	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35070	None	5	Human	Functional	pAC50	=	5.0	5.0	-10	28	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	4031	99367	None	27	Human	Functional	pAC50	=	5.0	5.0	-18	13	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	CHEMBL282121	99367	None	27	Human	Functional	pAC50	=	5.0	5.0	-18	13	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	1234	189330	None	32	Human	Functional	pAC50	=	5.0	5.0	-41	10	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1256940	189330	None	32	Human	Functional	pAC50	=	5.0	5.0	-41	10	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL51149	189330	None	32	Human	Functional	pAC50	=	5.0	5.0	-41	10	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	4452	2762	None	13	Human	Functional	pAC50	=	7.0	7.0	-162	21	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2762	None	13	Human	Functional	pAC50	=	7.0	7.0	-162	21	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2762	None	13	Human	Functional	pAC50	=	7.0	7.0	-162	21	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	1593	2340	None	41	Human	Functional	pAC50	=	6.0	6.0	-23	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	30668	2340	None	41	Human	Functional	pAC50	=	6.0	6.0	-23	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	30668.0	2340	None	41	Human	Functional	pAC50	=	6.0	6.0	-23	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	9868	2340	None	41	Human	Functional	pAC50	=	6.0	6.0	-23	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL17860	2340	None	41	Human	Functional	pAC50	=	6.0	6.0	-23	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	DB04948	2340	None	41	Human	Functional	pAC50	=	6.0	6.0	-23	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	55645	84404	None	3	Human	Functional	pAC50	=	6.0	6.0	-389	11	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	55645.0	84404	None	3	Human	Functional	pAC50	=	6.0	6.0	-389	11	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84404	None	3	Human	Functional	pAC50	=	6.0	6.0	-389	11	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	2477	745	None	38	Human	Functional	pAC50	=	6.9	6.9	-2	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	2477.0	745	None	38	Human	Functional	pAC50	=	6.9	6.9	-2	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	36	745	None	38	Human	Functional	pAC50	=	6.9	6.9	-2	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	437	745	None	38	Human	Functional	pAC50	=	6.9	6.9	-2	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	CHEMBL49	745	None	38	Human	Functional	pAC50	=	6.9	6.9	-2	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	DB00490	745	None	38	Human	Functional	pAC50	=	6.9	6.9	-2	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	2372	106524	None	30	Human	Functional	pAC50	=	5.9	5.9	-51	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL314010	106524	None	30	Human	Functional	pAC50	=	5.9	5.9	-51	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	4418	34231	None	58	Human	Functional	pAC50	=	5.9	5.9	-1	18	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	4418.0	34231	None	58	Human	Functional	pAC50	=	5.9	5.9	-1	18	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34231	None	58	Human	Functional	pAC50	=	5.9	5.9	-1	18	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	DB12092	34231	None	58	Human	Functional	pAC50	=	5.9	5.9	-1	18	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	2448	99377	None	50	Human	Functional	pAC50	=	5.9	5.9	-54	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	2448.0	99377	None	50	Human	Functional	pAC50	=	5.9	5.9	-54	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL28218	99377	None	50	Human	Functional	pAC50	=	5.9	5.9	-54	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	DB12401	99377	None	50	Human	Functional	pAC50	=	5.9	5.9	-54	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	47936	193531	None	56	Human	Functional	pAC50	=	5.9	5.9	-25	6	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193531	None	56	Human	Functional	pAC50	=	5.9	5.9	-25	6	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	2869	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-4265	5	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-4265	5	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60857	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-4265	5	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60857.0	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-4265	5	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL1185	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-4265	5	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	DB00315	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-4265	5	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	68617	207985	None	33	Human	Functional	pAC50	=	4.9	4.9	-34	30	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	207985	None	33	Human	Functional	pAC50	=	4.9	4.9	-34	30	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	207985	None	33	Human	Functional	pAC50	=	4.9	4.9	-34	30	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	4567	9950	None	29	Human	Functional	pAC50	=	4.9	4.9	-114	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL114655	9950	None	29	Human	Functional	pAC50	=	4.9	4.9	-114	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	2543	3707	None	46	Human	Functional	pAC50	=	4.9	4.9	-204	14	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358	3707	None	46	Human	Functional	pAC50	=	4.9	4.9	-204	14	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358.0	3707	None	46	Human	Functional	pAC50	=	4.9	4.9	-204	14	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	54	3707	None	46	Human	Functional	pAC50	=	4.9	4.9	-204	14	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	CHEMBL128	3707	None	46	Human	Functional	pAC50	=	4.9	4.9	-204	14	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	DB00669	3707	None	46	Human	Functional	pAC50	=	4.9	4.9	-204	14	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	34633	5466	None	43	Human	Functional	pAC50	=	4.9	4.9	1	2	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	5	1	6	4.1	CCOC(=O)Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1075	5466	None	43	Human	Functional	pAC50	=	4.9	4.9	1	2	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	5	1	6	4.1	CCOC(=O)Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	2162	41527	None	58	Human	Functional	pAC50	=	4.9	4.9	-15	22	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41527	None	58	Human	Functional	pAC50	=	4.9	4.9	-15	22	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	2165	206241	None	47	Human	Functional	pAC50	=	4.9	4.9	-8	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3647519	206241	None	47	Human	Functional	pAC50	=	4.9	4.9	-8	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL682	206241	None	47	Human	Functional	pAC50	=	4.9	4.9	-8	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3689	102826	None	36	Human	Functional	pAC50	=	5.9	5.9	-186	16	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1372983	102826	None	36	Human	Functional	pAC50	=	5.9	5.9	-186	16	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL305187	102826	None	36	Human	Functional	pAC50	=	5.9	5.9	-186	16	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	135398737	958	None	57	Human	Functional	pAC50	=	5.9	5.9	-295	43	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	135398737.0	958	None	57	Human	Functional	pAC50	=	5.9	5.9	-295	43	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	958	None	57	Human	Functional	pAC50	=	5.9	5.9	-295	43	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	958	None	57	Human	Functional	pAC50	=	5.9	5.9	-295	43	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	958	None	57	Human	Functional	pAC50	=	5.9	5.9	-295	43	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	958	None	57	Human	Functional	pAC50	=	5.9	5.9	-295	43	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	1212	1662	None	37	Human	Functional	pAC50	=	5.9	5.9	-1071	35	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	204	1662	None	37	Human	Functional	pAC50	=	5.9	5.9	-1071	35	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372	1662	None	37	Human	Functional	pAC50	=	5.9	5.9	-1071	35	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372.0	1662	None	37	Human	Functional	pAC50	=	5.9	5.9	-1071	35	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL726	1662	None	37	Human	Functional	pAC50	=	5.9	5.9	-1071	35	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00623	1662	None	37	Human	Functional	pAC50	=	5.9	5.9	-1071	35	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	103	4153	None	44	Human	Functional	pAC50	=	5.9	5.9	-154	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4153	None	44	Human	Functional	pAC50	=	5.9	5.9	-154	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4153	None	44	Human	Functional	pAC50	=	5.9	5.9	-154	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4153	None	44	Human	Functional	pAC50	=	5.9	5.9	-154	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4153	None	44	Human	Functional	pAC50	=	5.9	5.9	-154	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	150	2509	None	14	Human	Functional	pAC50	=	7.8	7.8	-5	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2509	None	14	Human	Functional	pAC50	=	7.8	7.8	-5	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2509	None	14	Human	Functional	pAC50	=	7.8	7.8	-5	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226.0	2509	None	14	Human	Functional	pAC50	=	7.8	7.8	-5	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2509	None	14	Human	Functional	pAC50	=	7.8	7.8	-5	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2509	None	14	Human	Functional	pAC50	=	7.8	7.8	-5	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	10531	1420	None	13	Human	Functional	pAC50	=	6.9	6.9	-48	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	10531.0	1420	None	13	Human	Functional	pAC50	=	6.9	6.9	-48	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1420	None	13	Human	Functional	pAC50	=	6.9	6.9	-48	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1420	None	13	Human	Functional	pAC50	=	6.9	6.9	-48	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1420	None	13	Human	Functional	pAC50	=	6.9	6.9	-48	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1420	None	13	Human	Functional	pAC50	=	6.9	6.9	-48	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	212	3806	None	35	Human	Functional	pAC50	=	5.9	5.9	-309	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3806	None	35	Human	Functional	pAC50	=	5.9	5.9	-309	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3806	None	35	Human	Functional	pAC50	=	5.9	5.9	-309	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651.0	3806	None	35	Human	Functional	pAC50	=	5.9	5.9	-309	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3806	None	35	Human	Functional	pAC50	=	5.9	5.9	-309	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3806	None	35	Human	Functional	pAC50	=	5.9	5.9	-309	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	71481097	120574	None	38	Human	Functional	pAC50	=	4.9	4.9	1	2	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	2	7	3.4	O=C(/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)NNc1cnccn1	10.1038/s41467-023-40064-9
	CHEMBL3545185	120574	None	38	Human	Functional	pAC50	=	4.9	4.9	1	2	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	2	7	3.4	O=C(/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)NNc1cnccn1	10.1038/s41467-023-40064-9
	187	255	None	24	Human	Functional	pAC50	=	6.8	6.8	-3	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	187.0	255	None	24	Human	Functional	pAC50	=	6.8	6.8	-3	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	294	255	None	24	Human	Functional	pAC50	=	6.8	6.8	-3	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	65	255	None	24	Human	Functional	pAC50	=	6.8	6.8	-3	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	8593	255	None	24	Human	Functional	pAC50	=	6.8	6.8	-3	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL667	255	None	24	Human	Functional	pAC50	=	6.8	6.8	-3	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB03128	255	None	24	Human	Functional	pAC50	=	6.8	6.8	-3	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	4640	78295	None	23	Human	Functional	pAC50	=	6.8	6.8	-1	11	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	78295	None	23	Human	Functional	pAC50	=	6.8	6.8	-1	11	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	213	3853	None	34	Human	Functional	pAC50	=	5.8	5.8	-33	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3853	None	34	Human	Functional	pAC50	=	5.8	5.8	-33	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3853	None	34	Human	Functional	pAC50	=	5.8	5.8	-33	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533.0	3853	None	34	Human	Functional	pAC50	=	5.8	5.8	-33	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3853	None	34	Human	Functional	pAC50	=	5.8	5.8	-33	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3853	None	34	Human	Functional	pAC50	=	5.8	5.8	-33	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	4066	207084	None	54	Human	Functional	pAC50	=	4.8	4.8	-954	16	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	4066.0	207084	None	54	Human	Functional	pAC50	=	4.8	4.8	-954	16	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	207084	None	54	Human	Functional	pAC50	=	4.8	4.8	-954	16	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	DB01071	207084	None	54	Human	Functional	pAC50	=	4.8	4.8	-954	16	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	1193	1656	None	64	Human	Functional	pAC50	=	4.8	4.8	-194	11	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	2447	1656	None	64	Human	Functional	pAC50	=	4.8	4.8	-194	11	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	3371	1656	None	64	Human	Functional	pAC50	=	4.8	4.8	-194	11	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL23588	1656	None	64	Human	Functional	pAC50	=	4.8	4.8	-194	11	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB02266	1656	None	64	Human	Functional	pAC50	=	4.8	4.8	-194	11	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	135398737	958	None	57	Human	Functional	pAC50	=	4.8	4.8	-295	43	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	135398737.0	958	None	57	Human	Functional	pAC50	=	4.8	4.8	-295	43	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	958	None	57	Human	Functional	pAC50	=	4.8	4.8	-295	43	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	958	None	57	Human	Functional	pAC50	=	4.8	4.8	-295	43	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	958	None	57	Human	Functional	pAC50	=	4.8	4.8	-295	43	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	958	None	57	Human	Functional	pAC50	=	4.8	4.8	-295	43	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	2389	3331	None	72	Human	Functional	pAC50	=	5.8	5.8	-812	29	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3331	None	72	Human	Functional	pAC50	=	5.8	5.8	-812	29	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073.0	3331	None	72	Human	Functional	pAC50	=	5.8	5.8	-812	29	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3331	None	72	Human	Functional	pAC50	=	5.8	5.8	-812	29	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3331	None	72	Human	Functional	pAC50	=	5.8	5.8	-812	29	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3331	None	72	Human	Functional	pAC50	=	5.8	5.8	-812	29	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	2470	3653	None	40	Human	Functional	pAC50	=	7.8	7.8	-3388	23	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	None	40	Human	Functional	pAC50	=	7.8	7.8	-3388	23	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	None	40	Human	Functional	pAC50	=	7.8	7.8	-3388	23	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	None	40	Human	Functional	pAC50	=	7.8	7.8	-3388	23	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	None	40	Human	Functional	pAC50	=	7.8	7.8	-3388	23	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	2169	44861	None	29	Human	Functional	pAC50	=	6.8	6.8	-1	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44861	None	29	Human	Functional	pAC50	=	6.8	6.8	-1	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	118422671	2757	None	41	Human	Functional	pAC50	=	5.8	5.8	-158	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2757	None	41	Human	Functional	pAC50	=	5.8	5.8	-158	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	189562	2757	None	41	Human	Functional	pAC50	=	5.8	5.8	-158	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	189562.0	2757	None	41	Human	Functional	pAC50	=	5.8	5.8	-158	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2757	None	41	Human	Functional	pAC50	=	5.8	5.8	-158	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301.0	2757	None	41	Human	Functional	pAC50	=	5.8	5.8	-158	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2757	None	41	Human	Functional	pAC50	=	5.8	5.8	-158	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	9844194	2757	None	41	Human	Functional	pAC50	=	5.8	5.8	-158	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	9844194.0	2757	None	41	Human	Functional	pAC50	=	5.8	5.8	-158	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL2365658	2757	None	41	Human	Functional	pAC50	=	5.8	5.8	-158	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL3526436	2757	None	41	Human	Functional	pAC50	=	5.8	5.8	-158	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2757	None	41	Human	Functional	pAC50	=	5.8	5.8	-158	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2757	None	41	Human	Functional	pAC50	=	5.8	5.8	-158	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	119570	3159	None	58	Human	Functional	pAC50	=	4.8	4.8	-10000	11	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	119570.0	3159	None	58	Human	Functional	pAC50	=	4.8	4.8	-10000	11	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2233	3159	None	58	Human	Functional	pAC50	=	4.8	4.8	-10000	11	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	953	3159	None	58	Human	Functional	pAC50	=	4.8	4.8	-10000	11	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	CHEMBL301265	3159	None	58	Human	Functional	pAC50	=	4.8	4.8	-10000	11	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	DB00413	3159	None	58	Human	Functional	pAC50	=	4.8	4.8	-10000	11	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2335	11852	None	18	Human	Functional	pAC50	=	4.8	4.8	-117	34	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11852	None	18	Human	Functional	pAC50	=	4.8	4.8	-117	34	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11852	None	18	Human	Functional	pAC50	=	4.8	4.8	-117	34	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11852	None	18	Human	Functional	pAC50	=	4.8	4.8	-117	34	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	21722	17999	None	26	Human	Functional	pAC50	=	4.8	4.8	-27	21	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	CHEMBL126224	17999	None	26	Human	Functional	pAC50	=	4.8	4.8	-27	21	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	16231	209968	None	39	Human	Functional	pAC50	=	4.8	4.8	-4	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	10.1038/s41467-023-40064-9
	CHEMBL945	209968	None	39	Human	Functional	pAC50	=	4.8	4.8	-4	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	10.1038/s41467-023-40064-9
	37	778	None	41	Human	Functional	pAC50	=	6.8	6.8	-9	12	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	778	None	41	Human	Functional	pAC50	=	6.8	6.8	-9	12	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	778	None	41	Human	Functional	pAC50	=	6.8	6.8	-9	12	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746.0	778	None	41	Human	Functional	pAC50	=	6.8	6.8	-9	12	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	778	None	41	Human	Functional	pAC50	=	6.8	6.8	-9	12	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	778	None	41	Human	Functional	pAC50	=	6.8	6.8	-9	12	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	16363	596	None	33	Human	Functional	pAC50	=	6.8	6.8	-31	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	16363.0	596	None	33	Human	Functional	pAC50	=	6.8	6.8	-31	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	596	None	33	Human	Functional	pAC50	=	6.8	6.8	-31	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	596	None	33	Human	Functional	pAC50	=	6.8	6.8	-31	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	596	None	33	Human	Functional	pAC50	=	6.8	6.8	-31	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	596	None	33	Human	Functional	pAC50	=	6.8	6.8	-31	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	3658	4107	None	38	Human	Functional	pAC50	=	7.8	7.8	-5	18	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4107	None	38	Human	Functional	pAC50	=	7.8	7.8	-5	18	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4107	None	38	Human	Functional	pAC50	=	7.8	7.8	-5	18	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709.0	4107	None	38	Human	Functional	pAC50	=	7.8	7.8	-5	18	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4107	None	38	Human	Functional	pAC50	=	7.8	7.8	-5	18	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4107	None	38	Human	Functional	pAC50	=	7.8	7.8	-5	18	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	31101	729	None	28	Human	Functional	pAC50	=	6.8	6.8	-53	29	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	31101.0	729	None	28	Human	Functional	pAC50	=	6.8	6.8	-53	29	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	None	28	Human	Functional	pAC50	=	6.8	6.8	-53	29	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	None	28	Human	Functional	pAC50	=	6.8	6.8	-53	29	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	None	28	Human	Functional	pAC50	=	6.8	6.8	-53	29	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	None	28	Human	Functional	pAC50	=	6.8	6.8	-53	29	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	4.8	4.8	-20	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	4.8	4.8	-20	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	4.8	4.8	-20	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	4.8	4.8	-20	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	2600	3779	None	53	Human	Functional	pAC50	=	4.8	4.8	-389	32	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3779	None	53	Human	Functional	pAC50	=	4.8	4.8	-389	32	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3779	None	53	Human	Functional	pAC50	=	4.8	4.8	-389	32	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3779	None	53	Human	Functional	pAC50	=	4.8	4.8	-389	32	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3779	None	53	Human	Functional	pAC50	=	4.8	4.8	-389	32	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	43815	187026	None	38	Human	Functional	pAC50	=	4.8	4.8	-169	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	187026	None	38	Human	Functional	pAC50	=	4.8	4.8	-169	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	187026	None	38	Human	Functional	pAC50	=	4.8	4.8	-169	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	2136	3095	None	24	Human	Functional	pAC50	=	4.8	4.8	-338	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3095	None	24	Human	Functional	pAC50	=	4.8	4.8	-338	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768.0	3095	None	24	Human	Functional	pAC50	=	4.8	4.8	-338	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3095	None	24	Human	Functional	pAC50	=	4.8	4.8	-338	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3095	None	24	Human	Functional	pAC50	=	4.8	4.8	-338	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3095	None	24	Human	Functional	pAC50	=	4.8	4.8	-338	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	6018	11069	None	60	Human	Functional	pAC50	=	4.8	4.8	-2	4	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	CHEMBL117785	11069	None	60	Human	Functional	pAC50	=	4.8	4.8	-2	4	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	4011	82440	None	34	Human	Functional	pAC50	=	4.8	4.8	-2137	26	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL21731	82440	None	34	Human	Functional	pAC50	=	4.8	4.8	-2137	26	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	4993	122423	None	61	Human	Functional	pAC50	=	4.8	4.8	-4	5	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL36	122423	None	61	Human	Functional	pAC50	=	4.8	4.8	-4	5	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	26248	161633	None	72	Human	Functional	pAC50	=	4.8	4.8	-1	11	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	161633	None	72	Human	Functional	pAC50	=	4.8	4.8	-1	11	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	3157	1470	None	44	Human	Functional	pAC50	=	4.8	4.8	-17378	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	3157.0	1470	None	44	Human	Functional	pAC50	=	4.8	4.8	-17378	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1470	None	44	Human	Functional	pAC50	=	4.8	4.8	-17378	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1470	None	44	Human	Functional	pAC50	=	4.8	4.8	-17378	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1470	None	44	Human	Functional	pAC50	=	4.8	4.8	-17378	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1470	None	44	Human	Functional	pAC50	=	4.8	4.8	-17378	21	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	2601	3780	None	25	Human	Functional	pAC50	=	6.8	6.8	-57	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3780	None	25	Human	Functional	pAC50	=	6.8	6.8	-57	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3780	None	25	Human	Functional	pAC50	=	6.8	6.8	-57	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3780	None	25	Human	Functional	pAC50	=	6.8	6.8	-57	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3780	None	25	Human	Functional	pAC50	=	6.8	6.8	-57	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	26987	949	None	27	Human	Functional	pAC50	=	4.7	4.7	-7079	34	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	26987.0	949	None	27	Human	Functional	pAC50	=	4.7	4.7	-7079	34	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	949	None	27	Human	Functional	pAC50	=	4.7	4.7	-7079	34	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	949	None	27	Human	Functional	pAC50	=	4.7	4.7	-7079	34	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	949	None	27	Human	Functional	pAC50	=	4.7	4.7	-7079	34	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	949	None	27	Human	Functional	pAC50	=	4.7	4.7	-7079	34	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	107641	61163	None	56	Human	Functional	pAC50	=	5.7	5.7	2	2	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	4	1	2	3.4	CCC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL1765292	61163	None	56	Human	Functional	pAC50	=	5.7	5.7	2	2	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	4	1	2	3.4	CCC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1	10.1038/s41467-023-40064-9
	129211	3749	None	48	Human	Functional	pAC50	=	7.7	7.7	-43	14	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	129211.0	3749	None	48	Human	Functional	pAC50	=	7.7	7.7	-43	14	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	2562	3749	None	48	Human	Functional	pAC50	=	7.7	7.7	-43	14	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	488	3749	None	48	Human	Functional	pAC50	=	7.7	7.7	-43	14	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	CHEMBL836	3749	None	48	Human	Functional	pAC50	=	7.7	7.7	-43	14	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	DB00706	3749	None	48	Human	Functional	pAC50	=	7.7	7.7	-43	14	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	134	2514	None	19	Human	Functional	pAC50	=	6.7	6.7	-97	18	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1775	2514	None	19	Human	Functional	pAC50	=	6.7	6.7	-97	18	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681	2514	None	19	Human	Functional	pAC50	=	6.7	6.7	-97	18	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681.0	2514	None	19	Human	Functional	pAC50	=	6.7	6.7	-97	18	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	CHEMBL1065	2514	None	19	Human	Functional	pAC50	=	6.7	6.7	-97	18	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	DB00247	2514	None	19	Human	Functional	pAC50	=	6.7	6.7	-97	18	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1890	2759	None	31	Human	Functional	pAC50	=	5.7	5.7	-5	28	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2759	None	31	Human	Functional	pAC50	=	5.7	5.7	-5	28	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2759	None	31	Human	Functional	pAC50	=	5.7	5.7	-5	28	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2759	None	31	Human	Functional	pAC50	=	5.7	5.7	-5	28	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2759	None	31	Human	Functional	pAC50	=	5.7	5.7	-5	28	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	2202	3132	None	63	Human	Functional	pAC50	=	4.7	4.7	-338	10	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4850	3132	None	63	Human	Functional	pAC50	=	4.7	4.7	-338	10	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4850.0	3132	None	63	Human	Functional	pAC50	=	4.7	4.7	-338	10	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	49	3132	None	63	Human	Functional	pAC50	=	4.7	4.7	-338	10	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	CHEMBL1371770	3132	None	63	Human	Functional	pAC50	=	4.7	4.7	-338	10	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	DB12478	3132	None	63	Human	Functional	pAC50	=	4.7	4.7	-338	10	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	2162	41527	None	58	Human	Functional	pAC50	=	4.7	4.7	-15	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41527	None	58	Human	Functional	pAC50	=	4.7	4.7	-15	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	1549120	198942	None	55	Human	Functional	pAC50	=	4.7	4.7	-13	19	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	319	4	1	4	2.9	CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL56337	198942	None	55	Human	Functional	pAC50	=	4.7	4.7	-13	19	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	319	4	1	4	2.9	CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1	10.1038/s41467-023-40064-9
	3149	12618	None	11	Human	Functional	pAC50	=	4.7	4.7	-60	26	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12618	None	11	Human	Functional	pAC50	=	4.7	4.7	-60	26	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	1210	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1213	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	2725	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036.0	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	4411	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	616	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	6976	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	716121	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1201353	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1554789	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL505	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB01114	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB13679	918	None	42	Human	Functional	pAC50	=	4.7	4.7	-2290	22	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	610479	15507	None	60	Human	Functional	pAC50	=	4.7	4.7	-2	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL121626	15507	None	60	Human	Functional	pAC50	=	4.7	4.7	-2	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	53276	95087	None	38	Human	Functional	pAC50	=	4.7	4.7	-1	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	304	5	3	5	3.0	CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N	10.1038/s41467-023-40064-9
	CHEMBL255044	95087	None	38	Human	Functional	pAC50	=	4.7	4.7	-1	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	304	5	3	5	3.0	CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N	10.1038/s41467-023-40064-9
	37264	189531	None	18	Human	Functional	pAC50	=	4.7	4.7	-14	3	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	435	6	2	10	1.3	COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL513301	189531	None	18	Human	Functional	pAC50	=	4.7	4.7	-14	3	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	435	6	2	10	1.3	COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC	10.1038/s41467-023-40064-9
	1043	1582	None	6	Human	Functional	pAC50	=	6.7	6.7	-1096	22	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	149	1582	None	6	Human	Functional	pAC50	=	6.7	6.7	-1096	22	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223	1582	None	6	Human	Functional	pAC50	=	6.7	6.7	-1096	22	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223.0	1582	None	6	Human	Functional	pAC50	=	6.7	6.7	-1096	22	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL442	1582	None	6	Human	Functional	pAC50	=	6.7	6.7	-1096	22	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00696	1582	None	6	Human	Functional	pAC50	=	6.7	6.7	-1096	22	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	124087	1389	None	72	Human	Functional	pAC50	=	4.6	4.6	-363	27	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	124087.0	1389	None	72	Human	Functional	pAC50	=	4.6	4.6	-363	27	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1389	None	72	Human	Functional	pAC50	=	4.6	4.6	-363	27	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1389	None	72	Human	Functional	pAC50	=	4.6	4.6	-363	27	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1389	None	72	Human	Functional	pAC50	=	4.6	4.6	-363	27	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1389	None	72	Human	Functional	pAC50	=	4.6	4.6	-363	27	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	154257	178724	None	43	Human	Functional	pAC50	=	4.6	4.6	-107	19	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178724	None	43	Human	Functional	pAC50	=	4.6	4.6	-107	19	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	5077	3578	None	61	Human	Functional	pAC50	=	4.6	4.6	-912	13	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	7552	3578	None	61	Human	Functional	pAC50	=	4.6	4.6	-912	13	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9913767	3578	None	61	Human	Functional	pAC50	=	4.6	4.6	-912	13	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9913767.0	3578	None	61	Human	Functional	pAC50	=	4.6	4.6	-912	13	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL238804	3578	None	61	Human	Functional	pAC50	=	4.6	4.6	-912	13	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	DB11362	3578	None	61	Human	Functional	pAC50	=	4.6	4.6	-912	13	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	2880	98061	None	34	Human	Functional	pAC50	=	4.6	4.6	-23	9	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	CHEMBL27289	98061	None	34	Human	Functional	pAC50	=	4.6	4.6	-23	9	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	102	4127	None	36	Human	Functional	pAC50	=	6.6	6.6	-23	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4127	None	36	Human	Functional	pAC50	=	6.6	6.6	-23	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4127	None	36	Human	Functional	pAC50	=	6.6	6.6	-23	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969.0	4127	None	36	Human	Functional	pAC50	=	6.6	6.6	-23	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4127	None	36	Human	Functional	pAC50	=	6.6	6.6	-23	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4127	None	36	Human	Functional	pAC50	=	6.6	6.6	-23	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	2105	3054	None	28	Human	Functional	pAC50	=	6.6	6.6	-23	25	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3054	None	28	Human	Functional	pAC50	=	6.6	6.6	-23	25	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3054	None	28	Human	Functional	pAC50	=	6.6	6.6	-23	25	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3054	None	28	Human	Functional	pAC50	=	6.6	6.6	-23	25	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3054	None	28	Human	Functional	pAC50	=	6.6	6.6	-23	25	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	636403	188375	None	19	Human	Functional	pAC50	=	5.6	5.6	3	7	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188375	None	19	Human	Functional	pAC50	=	5.6	5.6	3	7	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	123606	352	None	46	Human	Functional	pAC50	=	4.6	4.6	-2089	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	123606.0	352	None	46	Human	Functional	pAC50	=	4.6	4.6	-2089	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	128	352	None	46	Human	Functional	pAC50	=	4.6	4.6	-2089	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	7110	352	None	46	Human	Functional	pAC50	=	4.6	4.6	-2089	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	CHEMBL1505	352	None	46	Human	Functional	pAC50	=	4.6	4.6	-2089	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	DB00918	352	None	46	Human	Functional	pAC50	=	4.6	4.6	-2089	6	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	392622	56328	None	57	Human	Functional	pAC50	=	4.6	4.6	-21	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	CHEMBL163	56328	None	57	Human	Functional	pAC50	=	4.6	4.6	-21	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	1981	67484	None	62	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	6	1	6	3.5	COc1ccc2c(c1)c(CC(=O)OCC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL189171	67484	None	62	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	6	1	6	3.5	COc1ccc2c(c1)c(CC(=O)OCC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	25382	9159	None	27	Human	Functional	pAC50	=	4.6	4.6	-707	21	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9159	None	27	Human	Functional	pAC50	=	4.6	4.6	-707	21	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	5288783	14438	None	36	Human	Functional	pAC50	=	4.6	4.6	-2	3	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	5	3	3	5.1	C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)/C=C/[C@@H](O)C4CC4)CC[C@@H]23)C[C@@H](O)C[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL1200666	14438	None	36	Human	Functional	pAC50	=	4.6	4.6	-2	3	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	5	3	3	5.1	C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)/C=C/[C@@H](O)C4CC4)CC[C@@H]23)C[C@@H](O)C[C@@H]1O	10.1038/s41467-023-40064-9
	157355	57525	None	40	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	8	9	11	-5.8	OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)CO	10.1038/s41467-023-40064-9
	CHEMBL1661	57525	None	40	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	8	9	11	-5.8	OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)CO	10.1038/s41467-023-40064-9
	2515	78279	None	44	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	283	7	3	7	0.8	CCOC(=O)NNc1ccc(N(CC)CC(C)O)nn1	10.1038/s41467-023-40064-9
	CHEMBL2106561	78279	None	44	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	283	7	3	7	0.8	CCOC(=O)NNc1ccc(N(CC)CC(C)O)nn1	10.1038/s41467-023-40064-9
	168871	89164	None	10	Human	Functional	pAC50	=	6.6	6.6	-20	13	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89164	None	10	Human	Functional	pAC50	=	6.6	6.6	-20	13	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	209	3057	None	57	Human	Functional	pAC50	=	5.6	5.6	-1174	25	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2113	3057	None	57	Human	Functional	pAC50	=	5.6	5.6	-1174	25	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4748	3057	None	57	Human	Functional	pAC50	=	5.6	5.6	-1174	25	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4748.0	3057	None	57	Human	Functional	pAC50	=	5.6	5.6	-1174	25	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL567	3057	None	57	Human	Functional	pAC50	=	5.6	5.6	-1174	25	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00850	3057	None	57	Human	Functional	pAC50	=	5.6	5.6	-1174	25	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4940	14476	None	26	Human	Functional	pAC50	=	5.6	5.6	-91	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14476	None	26	Human	Functional	pAC50	=	5.6	5.6	-91	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	44112	121354	None	36	Human	Functional	pAC50	=	7.6	7.6	-3	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	CHEMBL357995	121354	None	36	Human	Functional	pAC50	=	7.6	7.6	-3	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	1816	2540	None	64	Human	Functional	pAC50	=	4.5	4.5	-4466	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2540	None	64	Human	Functional	pAC50	=	4.5	4.5	-4466	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205.0	2540	None	64	Human	Functional	pAC50	=	4.5	4.5	-4466	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2540	None	64	Human	Functional	pAC50	=	4.5	4.5	-4466	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2540	None	64	Human	Functional	pAC50	=	4.5	4.5	-4466	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2540	None	64	Human	Functional	pAC50	=	4.5	4.5	-4466	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	11504295	2923	None	40	Human	Functional	pAC50	=	4.5	4.5	-218776	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	11504295.0	2923	None	40	Human	Functional	pAC50	=	4.5	4.5	-218776	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2923	None	40	Human	Functional	pAC50	=	4.5	4.5	-218776	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2923	None	40	Human	Functional	pAC50	=	4.5	4.5	-218776	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2923	None	40	Human	Functional	pAC50	=	4.5	4.5	-218776	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2923	None	40	Human	Functional	pAC50	=	4.5	4.5	-218776	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	2467	67446	None	31	Human	Functional	pAC50	=	4.5	4.5	-6	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	8	0	5	2.8	COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1	10.1038/s41467-023-40064-9
	CHEMBL188921	67446	None	31	Human	Functional	pAC50	=	4.5	4.5	-6	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	8	0	5	2.8	COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1	10.1038/s41467-023-40064-9
	2247	505	None	55	Human	Functional	pAC50	=	5.5	5.5	-53	42	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	None	55	Human	Functional	pAC50	=	5.5	5.5	-53	42	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	None	55	Human	Functional	pAC50	=	5.5	5.5	-53	42	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	None	55	Human	Functional	pAC50	=	5.5	5.5	-53	42	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	None	55	Human	Functional	pAC50	=	5.5	5.5	-53	42	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	12582	950	None	27	Human	Functional	pAC50	=	5.5	5.5	-234	7	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	2783	950	None	27	Human	Functional	pAC50	=	5.5	5.5	-234	7	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	2783.0	950	None	27	Human	Functional	pAC50	=	5.5	5.5	-234	7	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	CHEMBL49080	950	None	27	Human	Functional	pAC50	=	5.5	5.5	-234	7	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	DB01407	950	None	27	Human	Functional	pAC50	=	5.5	5.5	-234	7	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	31101	729	None	28	Human	Functional	pAC50	=	5.5	5.5	-53	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	31101.0	729	None	28	Human	Functional	pAC50	=	5.5	5.5	-53	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	None	28	Human	Functional	pAC50	=	5.5	5.5	-53	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	None	28	Human	Functional	pAC50	=	5.5	5.5	-53	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	None	28	Human	Functional	pAC50	=	5.5	5.5	-53	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	None	28	Human	Functional	pAC50	=	5.5	5.5	-53	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	2337	3256	None	51	Human	Functional	pAC50	=	5.5	5.5	-10	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3256	None	51	Human	Functional	pAC50	=	5.5	5.5	-10	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3256	None	51	Human	Functional	pAC50	=	5.5	5.5	-10	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002.0	3256	None	51	Human	Functional	pAC50	=	5.5	5.5	-10	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3256	None	51	Human	Functional	pAC50	=	5.5	5.5	-10	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3256	None	51	Human	Functional	pAC50	=	5.5	5.5	-10	29	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	2393	3334	None	46	Human	Functional	pAC50	=	5.5	5.5	-75	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078	3334	None	46	Human	Functional	pAC50	=	5.5	5.5	-75	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078.0	3334	None	46	Human	Functional	pAC50	=	5.5	5.5	-75	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	51	3334	None	46	Human	Functional	pAC50	=	5.5	5.5	-75	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	CHEMBL905	3334	None	46	Human	Functional	pAC50	=	5.5	5.5	-75	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	DB00953	3334	None	46	Human	Functional	pAC50	=	5.5	5.5	-75	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5090	15568	None	65	Human	Functional	pAC50	=	4.5	4.5	-1	3	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL122	15568	None	65	Human	Functional	pAC50	=	4.5	4.5	-1	3	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	10.1038/s41467-023-40064-9
	3158	56283	None	21	Human	Functional	pAC50	=	4.5	4.5	-3890	28	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	3158.0	56283	None	21	Human	Functional	pAC50	=	4.5	4.5	-3890	28	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56283	None	21	Human	Functional	pAC50	=	4.5	4.5	-3890	28	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	DB01142	56283	None	21	Human	Functional	pAC50	=	4.5	4.5	-3890	28	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	2220	3134	None	58	Human	Functional	pAC50	=	5.5	5.5	-398	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3134	None	58	Human	Functional	pAC50	=	5.5	5.5	-398	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400.0	3134	None	58	Human	Functional	pAC50	=	5.5	5.5	-398	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3134	None	58	Human	Functional	pAC50	=	5.5	5.5	-398	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3134	None	58	Human	Functional	pAC50	=	5.5	5.5	-398	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3134	None	58	Human	Functional	pAC50	=	5.5	5.5	-398	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	9687	185441	None	21	Human	Functional	pAC50	=	4.4	4.4	-229	4	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	7	2	11	1.7	CCCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1OC(=O)CCC	10.1038/s41467-023-40064-9
	CHEMBL1522836	185441	None	21	Human	Functional	pAC50	=	4.4	4.4	-229	4	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	7	2	11	1.7	CCCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1OC(=O)CCC	10.1038/s41467-023-40064-9
	CHEMBL485980	185441	None	21	Human	Functional	pAC50	=	4.4	4.4	-229	4	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	7	2	11	1.7	CCCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1OC(=O)CCC	10.1038/s41467-023-40064-9
	47979	78239	None	45	Human	Functional	pAC50	=	5.4	5.4	-1202	9	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL2105581	78239	None	45	Human	Functional	pAC50	=	5.4	5.4	-1202	9	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	2543	3707	None	46	Human	Functional	pAC50	=	4.4	4.4	-204	14	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358	3707	None	46	Human	Functional	pAC50	=	4.4	4.4	-204	14	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358.0	3707	None	46	Human	Functional	pAC50	=	4.4	4.4	-204	14	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	54	3707	None	46	Human	Functional	pAC50	=	4.4	4.4	-204	14	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	CHEMBL128	3707	None	46	Human	Functional	pAC50	=	4.4	4.4	-204	14	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	DB00669	3707	None	46	Human	Functional	pAC50	=	4.4	4.4	-204	14	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	3899	210233	None	68	Human	Functional	pAC50	=	4.4	4.4	-478	7	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	2	1	3	3.3	Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	CHEMBL960	210233	None	68	Human	Functional	pAC50	=	4.4	4.4	-478	7	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	2	1	3	3.3	Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	2585	803	None	59	Human	Functional	pAC50	=	7.4	7.4	-36	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	2585.0	803	None	59	Human	Functional	pAC50	=	7.4	7.4	-36	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	803	None	59	Human	Functional	pAC50	=	7.4	7.4	-36	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	803	None	59	Human	Functional	pAC50	=	7.4	7.4	-36	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	803	None	59	Human	Functional	pAC50	=	7.4	7.4	-36	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	803	None	59	Human	Functional	pAC50	=	7.4	7.4	-36	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	242	470	None	70	Human	Functional	pAC50	=	5.4	5.4	-31	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	None	70	Human	Functional	pAC50	=	5.4	5.4	-31	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	None	70	Human	Functional	pAC50	=	5.4	5.4	-31	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795.0	470	None	70	Human	Functional	pAC50	=	5.4	5.4	-31	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	None	70	Human	Functional	pAC50	=	5.4	5.4	-31	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	None	70	Human	Functional	pAC50	=	5.4	5.4	-31	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	33624	3821	None	21	Human	Functional	pAC50	=	5.4	5.4	-8317	6	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	33624.0	3821	None	21	Human	Functional	pAC50	=	5.4	5.4	-8317	6	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	4061	3821	None	21	Human	Functional	pAC50	=	5.4	5.4	-8317	6	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	565	3821	None	21	Human	Functional	pAC50	=	5.4	5.4	-8317	6	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL499	3821	None	21	Human	Functional	pAC50	=	5.4	5.4	-8317	6	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	DB00373	3821	None	21	Human	Functional	pAC50	=	5.4	5.4	-8317	6	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	19675	51685	None	37	Human	Functional	pAC50	=	7.4	7.4	-3	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	51685	None	37	Human	Functional	pAC50	=	7.4	7.4	-3	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	2318	154946	None	18	Human	Functional	pAC50	=	5.4	5.4	-6	15	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154946	None	18	Human	Functional	pAC50	=	5.4	5.4	-6	15	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	100	3805	None	44	Human	Functional	pAC50	=	6.4	6.4	-162	38	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3805	None	44	Human	Functional	pAC50	=	6.4	6.4	-162	38	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3805	None	44	Human	Functional	pAC50	=	6.4	6.4	-162	38	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3805	None	44	Human	Functional	pAC50	=	6.4	6.4	-162	38	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3805	None	44	Human	Functional	pAC50	=	6.4	6.4	-162	38	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	135	2532	None	33	Human	Functional	pAC50	=	5.4	5.4	-354	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2532	None	33	Human	Functional	pAC50	=	5.4	5.4	-354	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2532	None	33	Human	Functional	pAC50	=	5.4	5.4	-354	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184.0	2532	None	33	Human	Functional	pAC50	=	5.4	5.4	-354	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2532	None	33	Human	Functional	pAC50	=	5.4	5.4	-354	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2532	None	33	Human	Functional	pAC50	=	5.4	5.4	-354	33	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	11658860	2344	None	24	Human	Functional	pAC50	=	5.4	5.4	-380	11	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2941	2344	None	24	Human	Functional	pAC50	=	5.4	5.4	-380	11	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	4374	2344	None	24	Human	Functional	pAC50	=	5.4	5.4	-380	11	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	CHEMBL360328	2344	None	24	Human	Functional	pAC50	=	5.4	5.4	-380	11	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	DB04871	2344	None	24	Human	Functional	pAC50	=	5.4	5.4	-380	11	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2726	919	None	48	Human	Functional	pAC50	=	5.4	5.4	-2089	42	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2726.0	919	None	48	Human	Functional	pAC50	=	5.4	5.4	-2089	42	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	919	None	48	Human	Functional	pAC50	=	5.4	5.4	-2089	42	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	919	None	48	Human	Functional	pAC50	=	5.4	5.4	-2089	42	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	919	None	48	Human	Functional	pAC50	=	5.4	5.4	-2089	42	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	919	None	48	Human	Functional	pAC50	=	5.4	5.4	-2089	42	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	137	370	None	37	Human	Functional	pAC50	=	5.3	5.3	-162	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2119	370	None	37	Human	Functional	pAC50	=	5.3	5.3	-162	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	563	370	None	37	Human	Functional	pAC50	=	5.3	5.3	-162	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	66368	370	None	37	Human	Functional	pAC50	=	5.3	5.3	-162	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL266195	370	None	37	Human	Functional	pAC50	=	5.3	5.3	-162	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00866	370	None	37	Human	Functional	pAC50	=	5.3	5.3	-162	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	118985385	1701	None	63	Human	Functional	pAC50	=	4.3	4.3	-7	2	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	330	5	3	5	1.9	OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N	10.1038/s41467-023-40064-9
	1258	1701	None	63	Human	Functional	pAC50	=	4.3	4.3	-7	2	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	330	5	3	5	1.9	OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N	10.1038/s41467-023-40064-9
	3440	1701	None	63	Human	Functional	pAC50	=	4.3	4.3	-7	2	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	330	5	3	5	1.9	OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N	10.1038/s41467-023-40064-9
	4839	1701	None	63	Human	Functional	pAC50	=	4.3	4.3	-7	2	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	330	5	3	5	1.9	OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N	10.1038/s41467-023-40064-9
	CHEMBL35	1701	None	63	Human	Functional	pAC50	=	4.3	4.3	-7	2	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	330	5	3	5	1.9	OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N	10.1038/s41467-023-40064-9
	DB00695	1701	None	63	Human	Functional	pAC50	=	4.3	4.3	-7	2	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	330	5	3	5	1.9	OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N	10.1038/s41467-023-40064-9
	2435	722	None	63	Human	Functional	pAC50	=	5.3	5.3	-1659	10	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	2435.0	722	None	63	Human	Functional	pAC50	=	5.3	5.3	-1659	10	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	395	722	None	63	Human	Functional	pAC50	=	5.3	5.3	-1659	10	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	520	722	None	63	Human	Functional	pAC50	=	5.3	5.3	-1659	10	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	5386	722	None	63	Human	Functional	pAC50	=	5.3	5.3	-1659	10	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL844	722	None	63	Human	Functional	pAC50	=	5.3	5.3	-1659	10	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	DB00484	722	None	63	Human	Functional	pAC50	=	5.3	5.3	-1659	10	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	135398744	68684	None	51	Human	Functional	pAC50	=	4.3	4.3	-151	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	7	1	8	1.6	CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12	10.1038/s41467-023-40064-9
	CHEMBL192	68684	None	51	Human	Functional	pAC50	=	4.3	4.3	-151	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	7	1	8	1.6	CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12	10.1038/s41467-023-40064-9
	2540	4402	None	68	Human	Functional	pAC50	=	5.3	5.3	-741	28	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4402	None	68	Human	Functional	pAC50	=	5.3	5.3	-741	28	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	228	445	None	20	Human	Functional	pAC50	=	5.3	5.3	-1412	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	445	None	20	Human	Functional	pAC50	=	5.3	5.3	-1412	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	445	None	20	Human	Functional	pAC50	=	5.3	5.3	-1412	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005.0	445	None	20	Human	Functional	pAC50	=	5.3	5.3	-1412	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	445	None	20	Human	Functional	pAC50	=	5.3	5.3	-1412	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	445	None	20	Human	Functional	pAC50	=	5.3	5.3	-1412	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	1343	1889	None	43	Human	Functional	pAC50	=	5.3	5.3	-616	12	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1889	None	43	Human	Functional	pAC50	=	5.3	5.3	-616	12	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519.0	1889	None	43	Human	Functional	pAC50	=	5.3	5.3	-616	12	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1889	None	43	Human	Functional	pAC50	=	5.3	5.3	-616	12	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	1889	None	43	Human	Functional	pAC50	=	5.3	5.3	-616	12	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	1889	None	43	Human	Functional	pAC50	=	5.3	5.3	-616	12	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	2419	3463	None	53	Human	Functional	pAC50	=	5.3	5.3	-9549	19	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152	3463	None	53	Human	Functional	pAC50	=	5.3	5.3	-9549	19	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152.0	3463	None	53	Human	Functional	pAC50	=	5.3	5.3	-9549	19	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	559	3463	None	53	Human	Functional	pAC50	=	5.3	5.3	-9549	19	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL1263	3463	None	53	Human	Functional	pAC50	=	5.3	5.3	-9549	19	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB00938	3463	None	53	Human	Functional	pAC50	=	5.3	5.3	-9549	19	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	3294	2006	None	61	Human	Functional	pAC50	=	7.3	7.3	-81	23	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2006	None	61	Human	Functional	pAC50	=	7.3	7.3	-81	23	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360.0	2006	None	61	Human	Functional	pAC50	=	7.3	7.3	-81	23	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2006	None	61	Human	Functional	pAC50	=	7.3	7.3	-81	23	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2006	None	61	Human	Functional	pAC50	=	7.3	7.3	-81	23	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2006	None	61	Human	Functional	pAC50	=	7.3	7.3	-81	23	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	82153	43915	None	34	Human	Functional	pAC50	=	6.3	6.3	-11	3	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	434	2	2	6	2.3	CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1	10.1038/s41467-023-40064-9
	CHEMBL1512	43915	None	34	Human	Functional	pAC50	=	6.3	6.3	-11	3	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	434	2	2	6	2.3	CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1	10.1038/s41467-023-40064-9
	4659569	22338	None	65	Human	Functional	pAC50	=	5.3	5.3	-4	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	273	3	2	5	2.5	Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1324	22338	None	65	Human	Functional	pAC50	=	5.3	5.3	-4	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	273	3	2	5	2.5	Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc1	10.1038/s41467-023-40064-9
	5991	206377	None	46	Human	Functional	pAC50	=	5.2	5.2	2	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	2	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL691	206377	None	46	Human	Functional	pAC50	=	5.2	5.2	2	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	2	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	45138674	16653	None	45	Human	Functional	pAC50	=	5.2	5.2	-3	6	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1241951	16653	None	45	Human	Functional	pAC50	=	5.2	5.2	-3	6	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	2551	794	None	13	Human	Functional	pAC50	=	5.2	5.2	-56	13	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	2551.0	794	None	13	Human	Functional	pAC50	=	5.2	5.2	-56	13	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	298	794	None	13	Human	Functional	pAC50	=	5.2	5.2	-56	13	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	488	794	None	13	Human	Functional	pAC50	=	5.2	5.2	-56	13	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL965	794	None	13	Human	Functional	pAC50	=	5.2	5.2	-56	13	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB00411	794	None	13	Human	Functional	pAC50	=	5.2	5.2	-56	13	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	180	401	None	38	Human	Functional	pAC50	=	5.2	5.2	-4265	38	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	None	38	Human	Functional	pAC50	=	5.2	5.2	-4265	38	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	None	38	Human	Functional	pAC50	=	5.2	5.2	-4265	38	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160.0	401	None	38	Human	Functional	pAC50	=	5.2	5.2	-4265	38	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	None	38	Human	Functional	pAC50	=	5.2	5.2	-4265	38	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	None	38	Human	Functional	pAC50	=	5.2	5.2	-4265	38	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	71731823	111768	None	45	Human	Functional	pAC50	=	5.2	5.2	-5	3	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	0	1	7	2.8	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21	10.1038/s41467-023-40064-9
	CHEMBL3286830	111768	None	45	Human	Functional	pAC50	=	5.2	5.2	-5	3	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	0	1	7	2.8	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21	10.1038/s41467-023-40064-9
	213046	2385	None	44	Human	Functional	pAC50	=	7.2	7.2	-2	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	213046.0	2385	None	44	Human	Functional	pAC50	=	7.2	7.2	-2	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2385	None	44	Human	Functional	pAC50	=	7.2	7.2	-2	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2385	None	44	Human	Functional	pAC50	=	7.2	7.2	-2	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2385	None	44	Human	Functional	pAC50	=	7.2	7.2	-2	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2385	None	44	Human	Functional	pAC50	=	7.2	7.2	-2	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	5311507	194927	None	32	Human	Functional	pAC50	=	5.2	5.2	-562	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	5311507.0	194927	None	32	Human	Functional	pAC50	=	5.2	5.2	-562	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL53904	194927	None	32	Human	Functional	pAC50	=	5.2	5.2	-562	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	DB01624	194927	None	32	Human	Functional	pAC50	=	5.2	5.2	-562	12	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	12574	2605	None	60	Human	Functional	pAC50	=	5.2	5.2	-104	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	4810	2605	None	60	Human	Functional	pAC50	=	5.2	5.2	-104	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	4810.0	2605	None	60	Human	Functional	pAC50	=	5.2	5.2	-104	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	CHEMBL19236	2605	None	60	Human	Functional	pAC50	=	5.2	5.2	-104	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	DB09242	2605	None	60	Human	Functional	pAC50	=	5.2	5.2	-104	8	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	2407	3372	None	50	Human	Functional	pAC50	=	6.2	6.2	-204	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3372	None	50	Human	Functional	pAC50	=	6.2	6.2	-204	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227.0	3372	None	50	Human	Functional	pAC50	=	6.2	6.2	-204	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3372	None	50	Human	Functional	pAC50	=	6.2	6.2	-204	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3372	None	50	Human	Functional	pAC50	=	6.2	6.2	-204	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3372	None	50	Human	Functional	pAC50	=	6.2	6.2	-204	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	2470	3653	None	40	Human	Functional	pAC50	=	5.2	5.2	-3388	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	None	40	Human	Functional	pAC50	=	5.2	5.2	-3388	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	None	40	Human	Functional	pAC50	=	5.2	5.2	-3388	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	None	40	Human	Functional	pAC50	=	5.2	5.2	-3388	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	None	40	Human	Functional	pAC50	=	5.2	5.2	-3388	23	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5591	157623	None	57	Human	Functional	pAC50	=	5.2	5.2	-8	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157623	None	57	Human	Functional	pAC50	=	5.2	5.2	-8	17	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	17676	7074	None	25	Human	Functional	pAC50	=	8.2	8.2	-1	13	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	17676.0	7074	None	25	Human	Functional	pAC50	=	8.2	8.2	-1	13	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	7074	None	25	Human	Functional	pAC50	=	8.2	8.2	-1	13	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	7074	None	25	Human	Functional	pAC50	=	8.2	8.2	-1	13	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	DB01063	7074	None	25	Human	Functional	pAC50	=	8.2	8.2	-1	13	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	214	3860	None	43	Human	Functional	pAC50	=	5.2	5.2	-776	28	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3860	None	43	Human	Functional	pAC50	=	5.2	5.2	-776	28	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3860	None	43	Human	Functional	pAC50	=	5.2	5.2	-776	28	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566.0	3860	None	43	Human	Functional	pAC50	=	5.2	5.2	-776	28	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3860	None	43	Human	Functional	pAC50	=	5.2	5.2	-776	28	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3860	None	43	Human	Functional	pAC50	=	5.2	5.2	-776	28	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3860	None	43	Human	Functional	pAC50	=	5.2	5.2	-776	28	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	71496458	115628	None	61	Human	Functional	pAC50	=	6.2	6.2	-1	16	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115628	None	61	Human	Functional	pAC50	=	6.2	6.2	-1	16	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	5803	162321	None	58	Human	Functional	pAC50	=	5.2	5.2	-1	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	162321	None	58	Human	Functional	pAC50	=	5.2	5.2	-1	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	3151	1462	None	65	Human	Functional	pAC50	=	5.1	5.1	-2691	24	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	3151.0	1462	None	65	Human	Functional	pAC50	=	5.1	5.1	-2691	24	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	945	1462	None	65	Human	Functional	pAC50	=	5.1	5.1	-2691	24	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	965	1462	None	65	Human	Functional	pAC50	=	5.1	5.1	-2691	24	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL219916	1462	None	65	Human	Functional	pAC50	=	5.1	5.1	-2691	24	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01184	1462	None	65	Human	Functional	pAC50	=	5.1	5.1	-2691	24	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2142	3096	None	36	Human	Functional	pAC50	=	5.1	5.1	-891	18	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	4920903	3096	None	36	Human	Functional	pAC50	=	5.1	5.1	-891	18	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	502	3096	None	36	Human	Functional	pAC50	=	5.1	5.1	-891	18	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775	3096	None	36	Human	Functional	pAC50	=	5.1	5.1	-891	18	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775.0	3096	None	36	Human	Functional	pAC50	=	5.1	5.1	-891	18	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL597	3096	None	36	Human	Functional	pAC50	=	5.1	5.1	-891	18	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00692	3096	None	36	Human	Functional	pAC50	=	5.1	5.1	-891	18	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	1971	2866	None	32	Human	Functional	pAC50	=	5.1	5.1	-10964	32	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2866	None	32	Human	Functional	pAC50	=	5.1	5.1	-10964	32	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2866	None	32	Human	Functional	pAC50	=	5.1	5.1	-10964	32	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543.0	2866	None	32	Human	Functional	pAC50	=	5.1	5.1	-10964	32	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2866	None	32	Human	Functional	pAC50	=	5.1	5.1	-10964	32	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2866	None	32	Human	Functional	pAC50	=	5.1	5.1	-10964	32	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	8730	198347	None	44	Human	Functional	pAC50	=	5.1	5.1	-1	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	90657408	198347	None	44	Human	Functional	pAC50	=	5.1	5.1	-1	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL559	198347	None	44	Human	Functional	pAC50	=	5.1	5.1	-1	5	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	2713	207729	None	57	Human	Functional	pAC50	=	5.1	5.1	-16	27	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	207729	None	57	Human	Functional	pAC50	=	5.1	5.1	-16	27	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	207729	None	57	Human	Functional	pAC50	=	5.1	5.1	-16	27	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	207729	None	57	Human	Functional	pAC50	=	5.1	5.1	-16	27	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	207729	None	57	Human	Functional	pAC50	=	5.1	5.1	-16	27	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	207729	None	57	Human	Functional	pAC50	=	5.1	5.1	-16	27	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	207729	None	57	Human	Functional	pAC50	=	5.1	5.1	-16	27	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	135409453	3773	None	26	Human	Functional	pAC50	=	6.1	6.1	-61	35	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3773	None	26	Human	Functional	pAC50	=	6.1	6.1	-61	35	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3773	None	26	Human	Functional	pAC50	=	6.1	6.1	-61	35	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	2583	208352	None	32	Human	Functional	pAC50	=	5.1	5.1	-8709	4	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	292	5	3	4	1.7	CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2	10.1038/s41467-023-40064-9
	2583.0	208352	None	32	Human	Functional	pAC50	=	5.1	5.1	-8709	4	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	292	5	3	4	1.7	CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2	10.1038/s41467-023-40064-9
	CHEMBL839	208352	None	32	Human	Functional	pAC50	=	5.1	5.1	-8709	4	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	292	5	3	4	1.7	CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2	10.1038/s41467-023-40064-9
	DB00521	208352	None	32	Human	Functional	pAC50	=	5.1	5.1	-8709	4	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	292	5	3	4	1.7	CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2	10.1038/s41467-023-40064-9
	202	1508	None	46	Human	Functional	pAC50	=	5.1	5.1	-6	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1508	None	46	Human	Functional	pAC50	=	5.1	5.1	-6	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1508	None	46	Human	Functional	pAC50	=	5.1	5.1	-6	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1508	None	46	Human	Functional	pAC50	=	5.1	5.1	-6	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1508	None	46	Human	Functional	pAC50	=	5.1	5.1	-6	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	124	2981	None	32	Human	Functional	pAC50	=	8.0	8.0	-12	24	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2981	None	32	Human	Functional	pAC50	=	8.0	8.0	-12	24	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2981	None	32	Human	Functional	pAC50	=	8.0	8.0	-12	24	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636.0	2981	None	32	Human	Functional	pAC50	=	8.0	8.0	-12	24	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2981	None	32	Human	Functional	pAC50	=	8.0	8.0	-12	24	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2981	None	32	Human	Functional	pAC50	=	8.0	8.0	-12	24	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	3036780	107587	None	16	Human	Functional	pAC50	=	8.0	8.0	-48	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	3036780.0	107587	None	16	Human	Functional	pAC50	=	8.0	8.0	-48	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	46780481	107587	None	16	Human	Functional	pAC50	=	8.0	8.0	-48	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107587	None	16	Human	Functional	pAC50	=	8.0	8.0	-48	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970.0	107587	None	16	Human	Functional	pAC50	=	8.0	8.0	-48	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107587	None	16	Human	Functional	pAC50	=	8.0	8.0	-48	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107587	None	16	Human	Functional	pAC50	=	8.0	8.0	-48	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL504548	107587	None	16	Human	Functional	pAC50	=	8.0	8.0	-48	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	DB06216	107587	None	16	Human	Functional	pAC50	=	8.0	8.0	-48	15	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	4746	207349	None	24	Human	Functional	pAC50	=	5.0	5.0	-8	19	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	207349	None	24	Human	Functional	pAC50	=	5.0	5.0	-8	19	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	207349	None	24	Human	Functional	pAC50	=	5.0	5.0	-8	19	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	71927	78434	None	13	Human	Functional	pAC50	=	5.0	5.0	2	2	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	202	2	1	3	0.9	COc1cc(N)cn[n+]1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL2106667	78434	None	13	Human	Functional	pAC50	=	5.0	5.0	2	2	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	202	2	1	3	0.9	COc1cc(N)cn[n+]1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL2110922	78434	None	13	Human	Functional	pAC50	=	5.0	5.0	2	2	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	202	2	1	3	0.9	COc1cc(N)cn[n+]1-c1ccccc1	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	5.0	5.0	-20	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	5.0	5.0	-20	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	5.0	5.0	-20	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	5.0	5.0	-20	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	2176	3127	None	40	Human	Functional	pAC50	=	7.0	7.0	-33	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	4828	3127	None	40	Human	Functional	pAC50	=	7.0	7.0	-33	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	4828.0	3127	None	40	Human	Functional	pAC50	=	7.0	7.0	-33	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	91	3127	None	40	Human	Functional	pAC50	=	7.0	7.0	-33	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL500	3127	None	40	Human	Functional	pAC50	=	7.0	7.0	-33	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	DB00960	3127	None	40	Human	Functional	pAC50	=	7.0	7.0	-33	8	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	2303	3187	None	44	Human	Functional	pAC50	=	6.0	6.0	-346	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	4946	3187	None	44	Human	Functional	pAC50	=	6.0	6.0	-346	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	564	3187	None	44	Human	Functional	pAC50	=	6.0	6.0	-346	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	63	3187	None	44	Human	Functional	pAC50	=	6.0	6.0	-346	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	91536	3187	None	44	Human	Functional	pAC50	=	6.0	6.0	-346	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL27	3187	None	44	Human	Functional	pAC50	=	6.0	6.0	-346	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL452861	3187	None	44	Human	Functional	pAC50	=	6.0	6.0	-346	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	DB00571	3187	None	44	Human	Functional	pAC50	=	6.0	6.0	-346	20	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	5.0	5.0	-20	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	5.0	5.0	-20	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	5.0	5.0	-20	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	5.0	5.0	-20	17	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	2865	4143	None	47	Human	Functional	pAC50	=	6.0	6.0	-8	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4143	None	47	Human	Functional	pAC50	=	6.0	6.0	-8	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4143	None	47	Human	Functional	pAC50	=	6.0	6.0	-8	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854.0	4143	None	47	Human	Functional	pAC50	=	6.0	6.0	-8	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4143	None	47	Human	Functional	pAC50	=	6.0	6.0	-8	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4143	None	47	Human	Functional	pAC50	=	6.0	6.0	-8	20	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	1353	1911	None	63	Human	Functional	pAC50	=	6.0	6.0	-457	39	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1911	None	63	Human	Functional	pAC50	=	6.0	6.0	-457	39	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559.0	1911	None	63	Human	Functional	pAC50	=	6.0	6.0	-457	39	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1911	None	63	Human	Functional	pAC50	=	6.0	6.0	-457	39	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1911	None	63	Human	Functional	pAC50	=	6.0	6.0	-457	39	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1911	None	63	Human	Functional	pAC50	=	6.0	6.0	-457	39	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	10324985	76809	None	6	Human	Functional	pEC50	=	11	11.0	-	1	Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationAgonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL199824	76809	None	6	Human	Functional	pEC50	=	11	11.0	-	1	Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationAgonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL2068762	76809	None	6	Human	Functional	pEC50	=	11	11.0	-	1	Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationAgonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	132257058	181015	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	449	7	2	4	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3c2CCN3)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4757755	181015	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	449	7	2	4	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3c2CCN3)CC1	10.1021/acs.jmedchem.0c00814
	132247312	180761	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	465	8	2	4	4.1	CC(=O)Nc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4755058	180761	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	465	8	2	4	4.1	CC(=O)Nc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	24804775	19350	None	0	Human	Functional	pEC50	=	10.5	10.5	31	2	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay	ChEMBL	412	4	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1290716	19350	None	0	Human	Functional	pEC50	=	10.5	10.5	31	2	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay	ChEMBL	412	4	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	10324985	76809	None	6	Human	Functional	pEC50	=	10.3	10.3	-	1	Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S bindingAgonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL199824	76809	None	6	Human	Functional	pEC50	=	10.3	10.3	-	1	Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S bindingAgonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL2068762	76809	None	6	Human	Functional	pEC50	=	10.3	10.3	-	1	Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S bindingAgonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	132247307	180516	None	0	Human	Functional	pEC50	=	10.2	10.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	481	8	2	4	4.6	CC(=O)Nc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4752177	180516	None	0	Human	Functional	pEC50	=	10.2	10.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	481	8	2	4	4.6	CC(=O)Nc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	89638711	114346	None	6	Human	Functional	pEC50	=	10.1	10.1	-	1	Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry	ChEMBL	344	6	0	8	-0.1	Cn1c(=O)cnn(CCCCN2CCN(c3ccccn3)CC2)c1=O	10.1016/j.bmcl.2014.07.048
	CHEMBL3330612	114346	None	6	Human	Functional	pEC50	=	10.1	10.1	-	1	Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry	ChEMBL	344	6	0	8	-0.1	Cn1c(=O)cnn(CCCCN2CCN(c3ccccn3)CC2)c1=O	10.1016/j.bmcl.2014.07.048
	132247301	180875	None	0	Human	Functional	pEC50	=	10.1	10.1	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	447	7	2	3	4.6	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3[nH]ccc23)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4756233	180875	None	0	Human	Functional	pEC50	=	10.1	10.1	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	447	7	2	3	4.6	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3[nH]ccc23)CC1	10.1021/acs.jmedchem.0c00814
	156010510	177209	None	0	Human	Functional	pEC50	=	10	10.0	70	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	426	6	0	8	2.8	O=c1n(CCCCN2CCN(c3cccc4scnc34)CC2)nc2c(F)cccn12	10.1016/j.bmcl.2020.127027
	CHEMBL4633397	177209	None	0	Human	Functional	pEC50	=	10	10.0	70	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	426	6	0	8	2.8	O=c1n(CCCCN2CCN(c3cccc4scnc34)CC2)nc2c(F)cccn12	10.1016/j.bmcl.2020.127027
	156020913	178141	None	0	Human	Functional	pEC50	=	10	10.0	263	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	425	6	0	7	3.5	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2ccc(F)cn12	10.1016/j.bmcl.2020.127027
	CHEMBL4647011	178141	None	0	Human	Functional	pEC50	=	10	10.0	263	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	425	6	0	7	3.5	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2ccc(F)cn12	10.1016/j.bmcl.2020.127027
	156021409	178216	None	0	Human	Functional	pEC50	=	10	10.0	4073	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	475	6	0	7	4.6	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2c(Cl)cc(Cl)cn12	10.1016/j.bmcl.2020.127027
	CHEMBL4648027	178216	None	0	Human	Functional	pEC50	=	10	10.0	4073	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	475	6	0	7	4.6	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2c(Cl)cc(Cl)cn12	10.1016/j.bmcl.2020.127027
	21830793	91869	None	12	Human	Functional	pEC50	=	10	10.0	-	1	Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmcl.2014.07.048
	CHEMBL2413154	91869	None	12	Human	Functional	pEC50	=	10	10.0	-	1	Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmcl.2014.07.048
	21830793	91869	None	12	Human	Functional	pEC50	=	10	10.0	-	1	Partial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS bindingPartial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS binding	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
	CHEMBL2413154	91869	None	12	Human	Functional	pEC50	=	10	10.0	-	1	Partial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS bindingPartial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS binding	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
	132256760	183350	None	0	Human	Functional	pEC50	=	10.0	10.0	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	437	8	2	4	4.1	CNc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4796345	183350	None	0	Human	Functional	pEC50	=	10.0	10.0	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	437	8	2	4	4.1	CNc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	4223	3992	None	57	Human	Functional	pEC50	=	9.9	9.9	7	17	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmc.2018.04.037
	6918314	3992	None	57	Human	Functional	pEC50	=	9.9	9.9	7	17	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmc.2018.04.037
	6918314.0	3992	None	57	Human	Functional	pEC50	=	9.9	9.9	7	17	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmc.2018.04.037
	7427	3992	None	57	Human	Functional	pEC50	=	9.9	9.9	7	17	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmc.2018.04.037
	CHEMBL439849	3992	None	57	Human	Functional	pEC50	=	9.9	9.9	7	17	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmc.2018.04.037
	DB06684	3992	None	57	Human	Functional	pEC50	=	9.9	9.9	7	17	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmc.2018.04.037
	4223	3992	None	57	Human	Functional	pEC50	=	9.9	9.9	7	17	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmc.2019.01.025
	6918314	3992	None	57	Human	Functional	pEC50	=	9.9	9.9	7	17	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmc.2019.01.025
	6918314.0	3992	None	57	Human	Functional	pEC50	=	9.9	9.9	7	17	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmc.2019.01.025
	7427	3992	None	57	Human	Functional	pEC50	=	9.9	9.9	7	17	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmc.2019.01.025
	CHEMBL439849	3992	None	57	Human	Functional	pEC50	=	9.9	9.9	7	17	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmc.2019.01.025
	DB06684	3992	None	57	Human	Functional	pEC50	=	9.9	9.9	7	17	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.bmc.2019.01.025
	18922713	98551	None	0	Human	Functional	pEC50	=	9.9	9.9	-	1	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	10.1021/jm000339w
	CHEMBL276031	98551	None	0	Human	Functional	pEC50	=	9.9	9.9	-	1	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	10.1021/jm000339w
	132256714	180490	None	0	Human	Functional	pEC50	=	9.9	9.9	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	438	8	1	4	4.1	COc1ccccc1OCCNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4751777	180490	None	0	Human	Functional	pEC50	=	9.9	9.9	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	438	8	1	4	4.1	COc1ccccc1OCCNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	71294258	114350	None	0	Human	Functional	pEC50	=	9.7	9.7	-	1	Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry	ChEMBL	362	6	0	8	0.1	Cn1c(=O)cnn(CCCCN2CCN(c3cccc(F)n3)CC2)c1=O	10.1016/j.bmcl.2014.07.048
	CHEMBL3330616	114350	None	0	Human	Functional	pEC50	=	9.7	9.7	-	1	Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry	ChEMBL	362	6	0	8	0.1	Cn1c(=O)cnn(CCCCN2CCN(c3cccc(F)n3)CC2)c1=O	10.1016/j.bmcl.2014.07.048
	1809	134	None	25	Human	Functional	pEC50	=	9.6	9.6	12	8	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2023.115285
	4	134	None	25	Human	Functional	pEC50	=	9.6	9.6	12	8	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2023.115285
	CHEMBL18840	134	None	25	Human	Functional	pEC50	=	9.6	9.6	12	8	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2023.115285
	1809	134	None	25	Human	Functional	pEC50	=	9.6	9.6	12	8	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2023.115285
	4	134	None	25	Human	Functional	pEC50	=	9.6	9.6	12	8	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2023.115285
	CHEMBL18840	134	None	25	Human	Functional	pEC50	=	9.6	9.6	12	8	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	10.1016/j.ejmech.2023.115285
	11948707	166262	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cellsAgonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cells	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
	CHEMBL426317	166262	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cellsAgonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cells	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
	89638708	114337	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry	ChEMBL	343	6	0	7	0.5	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3)CC2)c1=O	10.1016/j.bmcl.2014.07.048
	CHEMBL3330603	114337	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry	ChEMBL	343	6	0	7	0.5	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3)CC2)c1=O	10.1016/j.bmcl.2014.07.048
	132256714	180490	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	438	8	1	4	4.1	COc1ccccc1OCCNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4751777	180490	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	438	8	1	4	4.1	COc1ccccc1OCCNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	132256724	180853	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	459	7	1	4	4.6	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3cccnc23)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4756041	180853	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	459	7	1	4	4.6	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3cccnc23)CC1	10.1021/acs.jmedchem.0c00814
	11382841	18428	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	360	9	2	3	4.1	COc1ccc(F)cc1OCCNCCCc1c[nH]c2ccc(F)cc12	10.1021/jm0304010
	CHEMBL127171	18428	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	360	9	2	3	4.1	COc1ccc(F)cc1OCCNCCCc1c[nH]c2ccc(F)cc12	10.1021/jm0304010
	145961968	161606	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	531	6	2	4	6.1	Nc1c2c(nc3cccc(N4CCN(CCCCc5c[nH]c6ccc(Br)cc56)CC4)c13)CCCC2	10.1016/j.bmc.2018.04.037
	CHEMBL4128200	161606	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	531	6	2	4	6.1	Nc1c2c(nc3cccc(N4CCN(CCCCc5c[nH]c6ccc(Br)cc56)CC4)c13)CCCC2	10.1016/j.bmc.2018.04.037
	145960843	161500	None	0	Human	Functional	pEC50	=	9.4	9.4	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	478	6	2	5	5.2	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4cccc5nc6c(c(N)c45)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	CHEMBL4126644	161500	None	0	Human	Functional	pEC50	=	9.4	9.4	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	478	6	2	5	5.2	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4cccc5nc6c(c(N)c45)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	5	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-33	26	Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S bindingAgonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050725j
	5202	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-33	26	Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S bindingAgonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050725j
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-33	26	Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S bindingAgonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050725j
	DB08839	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-33	26	Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S bindingAgonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050725j
	162646896	179678	None	0	Human	Functional	pEC50	=	9.3	9.3	3	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	421	6	0	5	4.2	O=C1COc2ccccc2N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2020.112572
	CHEMBL4741908	179678	None	0	Human	Functional	pEC50	=	9.3	9.3	3	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	421	6	0	5	4.2	O=C1COc2ccccc2N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2020.112572
	145961773	161643	None	0	Human	Functional	pEC50	=	9.2	9.2	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	464	6	2	5	4.8	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4cccc5nc6c(c(N)c45)CCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	CHEMBL4128689	161643	None	0	Human	Functional	pEC50	=	9.2	9.2	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	464	6	2	5	4.8	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4cccc5nc6c(c(N)c45)CCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	145962474	161741	None	0	Human	Functional	pEC50	=	9.2	9.2	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	467	6	2	4	5.6	Cc1ccc2[nH]cc(CCCCN3CCN(c4cccc5nc6c(c(N)c45)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	CHEMBL4130230	161741	None	0	Human	Functional	pEC50	=	9.2	9.2	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	467	6	2	4	5.6	Cc1ccc2[nH]cc(CCCCN3CCN(c4cccc5nc6c(c(N)c45)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	73346042	91868	None	6	Human	Functional	pEC50	=	9.2	9.2	-	1	Partial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS bindingPartial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS binding	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
	CHEMBL2413153	91868	None	6	Human	Functional	pEC50	=	9.2	9.2	-	1	Partial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS bindingPartial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS binding	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
	132247308	181867	None	0	Human	Functional	pEC50	=	9.2	9.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	451	8	2	4	3.2	NC(=O)c1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4777581	181867	None	0	Human	Functional	pEC50	=	9.2	9.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	451	8	2	4	3.2	NC(=O)c1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	5	139	None	45	Human	Functional	pEC50	=	9.2	9.2	-33	26	Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cellsAgonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2006.01.052
	5202	139	None	45	Human	Functional	pEC50	=	9.2	9.2	-33	26	Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cellsAgonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2006.01.052
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.2	9.2	-33	26	Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cellsAgonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2006.01.052
	DB08839	139	None	45	Human	Functional	pEC50	=	9.2	9.2	-33	26	Agonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cellsAgonist activity assessed by stimulation of [35S]GTP-gamma-S binding to human 5HT1A receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2006.01.052
	145974939	164792	None	0	Human	Functional	pEC50	=	9.2	9.2	11	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	442	8	1	6	3.8	CNC(=O)c1cc(OCCCCN2CCN(c3cccc4sc(F)cc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4217182	164792	None	0	Human	Functional	pEC50	=	9.2	9.2	11	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	442	8	1	6	3.8	CNC(=O)c1cc(OCCCCN2CCN(c3cccc4sc(F)cc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	145963079	161672	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	471	6	2	4	5.5	Nc1c2c(nc3cccc(N4CCN(CCCCc5c[nH]c6ccc(F)cc56)CC4)c13)CCCC2	10.1016/j.bmc.2018.04.037
	CHEMBL4129170	161672	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	471	6	2	4	5.5	Nc1c2c(nc3cccc(N4CCN(CCCCc5c[nH]c6ccc(F)cc56)CC4)c13)CCCC2	10.1016/j.bmc.2018.04.037
	10694660	178488	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	445	6	2	4	4.0	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3cc[nH]n3)n2)CC1	10.1021/jm9806906
	CHEMBL46539	178488	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	445	6	2	4	4.0	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3cc[nH]n3)n2)CC1	10.1021/jm9806906
	145962581	161572	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	487	6	2	4	6.0	Nc1c2c(nc3cccc(N4CCN(CCCCc5c[nH]c6ccc(Cl)cc56)CC4)c13)CCCC2	10.1016/j.bmc.2018.04.037
	CHEMBL4127774	161572	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	487	6	2	4	6.0	Nc1c2c(nc3cccc(N4CCN(CCCCc5c[nH]c6ccc(Cl)cc56)CC4)c13)CCCC2	10.1016/j.bmc.2018.04.037
	10474042	170356	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	3	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	365	6	0	4	4.1	COc1cccc2c1CCCC2CCCN1CCN(c2ccccn2)CC1	10.1016/j.bmc.2015.05.042
	CHEMBL444590	170356	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	3	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	365	6	0	4	4.1	COc1cccc2c1CCCC2CCCN1CCN(c2ccccn2)CC1	10.1016/j.bmc.2015.05.042
	44336170	107320	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	In vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMPIn vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMP	ChEMBL	413	5	1	5	2.9	CC1CN(c2cccc3c2OCCO3)CC(C)N1CCNC(=O)c1ccc(F)cc1	10.1021/jm960496o
	CHEMBL316960	107320	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	In vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMPIn vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMP	ChEMBL	413	5	1	5	2.9	CC1CN(c2cccc3c2OCCO3)CC(C)N1CCNC(=O)c1ccc(F)cc1	10.1021/jm960496o
	10430183	208086	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	In vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMPIn vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMP	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1021/jm960496o
	CHEMBL81728	208086	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	In vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMPIn vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMP	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1021/jm960496o
	4223	3992	None	57	Human	Functional	pEC50	=	9.1	9.1	7	17	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.ejmech.2021.114045
	6918314	3992	None	57	Human	Functional	pEC50	=	9.1	9.1	7	17	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.ejmech.2021.114045
	6918314.0	3992	None	57	Human	Functional	pEC50	=	9.1	9.1	7	17	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.ejmech.2021.114045
	7427	3992	None	57	Human	Functional	pEC50	=	9.1	9.1	7	17	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.ejmech.2021.114045
	CHEMBL439849	3992	None	57	Human	Functional	pEC50	=	9.1	9.1	7	17	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.ejmech.2021.114045
	DB06684	3992	None	57	Human	Functional	pEC50	=	9.1	9.1	7	17	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1016/j.ejmech.2021.114045
	162652355	180472	None	0	Human	Functional	pEC50	=	9.1	9.1	3	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	470	6	1	6	3.8	Nc1ccc2c(c1)N(CCCCN1CCN(c3cccc4sccc34)CC1)S(=O)(=O)CC2	10.1016/j.ejmech.2020.112572
	CHEMBL4751542	180472	None	0	Human	Functional	pEC50	=	9.1	9.1	3	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	470	6	1	6	3.8	Nc1ccc2c(c1)N(CCCCN1CCN(c3cccc4sccc34)CC1)S(=O)(=O)CC2	10.1016/j.ejmech.2020.112572
	10020855	189379	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	351	4	0	4	3.9	COc1cccc([C@H]2CC[C@H](N3CCN(c4ccccn4)CC3)CC2)c1	10.1016/j.bmc.2015.05.042
	CHEMBL511857	189379	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	351	4	0	4	3.9	COc1cccc([C@H]2CC[C@H](N3CCN(c4ccccn4)CC3)CC2)c1	10.1016/j.bmc.2015.05.042
	118713100	114348	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry	ChEMBL	362	6	0	8	0.1	Cn1c(=O)cnn(CCCCN2CCN(c3ncccc3F)CC2)c1=O	10.1016/j.bmcl.2014.07.048
	CHEMBL3330614	114348	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometryAgonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry	ChEMBL	362	6	0	8	0.1	Cn1c(=O)cnn(CCCCN2CCN(c3ncccc3F)CC2)c1=O	10.1016/j.bmcl.2014.07.048
	10430183	208086	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL81728	208086	None	0	Human	Functional	pEC50	=	9.1	9.1	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	145993172	167092	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	423	6	0	5	3.8	O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4287980	167092	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	423	6	0	5	3.8	O=C1C2CC=CCC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	145971556	164593	None	0	Human	Functional	pEC50	=	9.1	9.1	29	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	436	8	1	5	3.7	CNC(=O)c1cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4214528	164593	None	0	Human	Functional	pEC50	=	9.1	9.1	29	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	436	8	1	5	3.7	CNC(=O)c1cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	10082834	34490	None	1	Human	Functional	pEC50	=	9.0	9.0	-	1	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	236	4	1	2	2.4	COc1ccc2[nH]cc(CCN(C)C)c2c1F	10.1021/jm000339w
	CHEMBL142862	34490	None	1	Human	Functional	pEC50	=	9.0	9.0	-	1	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	236	4	1	2	2.4	COc1ccc2[nH]cc(CCN(C)C)c2c1F	10.1021/jm000339w
	10430183	208086	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL81728	208086	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	5	139	None	45	Human	Functional	pEC50	=	9	9.0	-33	26	Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationAgonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050725j
	5202	139	None	45	Human	Functional	pEC50	=	9	9.0	-33	26	Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationAgonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050725j
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9	9.0	-33	26	Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationAgonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050725j
	DB08839	139	None	45	Human	Functional	pEC50	=	9	9.0	-33	26	Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationAgonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050725j
	138692457	182539	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	438	8	1	4	4.1	COc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4786067	182539	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	438	8	1	4	4.1	COc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	145991127	167026	None	0	Human	Functional	pEC50	=	9.0	9.0	34	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	437	6	0	5	4.2	O=C1c2cccc(F)c2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4286905	167026	None	0	Human	Functional	pEC50	=	9.0	9.0	34	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	437	6	0	5	4.2	O=C1c2cccc(F)c2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	162658259	181139	None	0	Human	Functional	pEC50	=	9.0	9.0	16	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	471	6	1	6	3.9	O=S1(=O)CCc2ccc(O)cc2N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2020.112572
	CHEMBL4759331	181139	None	0	Human	Functional	pEC50	=	9.0	9.0	16	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	471	6	1	6	3.9	O=S1(=O)CCc2ccc(O)cc2N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2020.112572
	10813901	178504	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	461	6	2	4	4.5	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3cc[nH]n3)n2)CC1	10.1021/jm9806906
	CHEMBL46582	178504	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	461	6	2	4	4.5	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3cc[nH]n3)n2)CC1	10.1021/jm9806906
	145993577	167482	None	0	Human	Functional	pEC50	=	8.9	8.9	9	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	453	6	0	5	4.9	O=C1CC2(CCCCC2)CC(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4295055	167482	None	0	Human	Functional	pEC50	=	8.9	8.9	9	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	453	6	0	5	4.9	O=C1CC2(CCCCC2)CC(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	156014350	177316	None	0	Human	Functional	pEC50	=	8.9	8.9	22	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	443	6	0	7	3.6	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2c(F)cc(F)cn12	10.1016/j.bmcl.2020.127027
	CHEMBL4635414	177316	None	0	Human	Functional	pEC50	=	8.9	8.9	22	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	443	6	0	7	3.6	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2c(F)cc(F)cn12	10.1016/j.bmcl.2020.127027
	145952639	161512	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	453	6	2	4	5.3	Nc1c2c(nc3cccc(N4CCN(CCCCc5c[nH]c6ccccc56)CC4)c13)CCCC2	10.1016/j.bmc.2018.04.037
	CHEMBL4126818	161512	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	453	6	2	4	5.3	Nc1c2c(nc3cccc(N4CCN(CCCCc5c[nH]c6ccccc56)CC4)c13)CCCC2	10.1016/j.bmc.2018.04.037
	21689040	41983	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Agonist activity at human 5-HT1AR expressed in HEK293 cells assessed as increase in calcium flux by fluorimetric methodAgonist activity at human 5-HT1AR expressed in HEK293 cells assessed as increase in calcium flux by fluorimetric method	ChEMBL	261	6	1	2	3.8	CCCCN(CCC)C1CCc2cccc(O)c2C1	10.1016/j.ejmech.2018.01.002
	CHEMBL149482	41983	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Agonist activity at human 5-HT1AR expressed in HEK293 cells assessed as increase in calcium flux by fluorimetric methodAgonist activity at human 5-HT1AR expressed in HEK293 cells assessed as increase in calcium flux by fluorimetric method	ChEMBL	261	6	1	2	3.8	CCCCN(CCC)C1CCc2cccc(O)c2C1	10.1016/j.ejmech.2018.01.002
	145966333	164155	None	0	Human	Functional	pEC50	=	8.9	8.9	19	6	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cc(OCCCCN2CCN(c3cccc4sccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4209188	164155	None	0	Human	Functional	pEC50	=	8.9	8.9	19	6	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cc(OCCCCN2CCN(c3cccc4sccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	145993117	167017	None	0	Human	Functional	pEC50	=	8.9	8.9	8	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	427	7	0	5	4.4	CCC1(C)CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)C(=O)C1	10.1016/j.ejmech.2017.12.099
	CHEMBL4286717	167017	None	0	Human	Functional	pEC50	=	8.9	8.9	8	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	427	7	0	5	4.4	CCC1(C)CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)C(=O)C1	10.1016/j.ejmech.2017.12.099
	11046644	30712	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	361	6	0	4	4.0	COc1cccc2c(CCCN3CCN(c4ccccn4)CC3)cccc12	10.1016/j.bmc.2015.05.042
	CHEMBL139505	30712	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	361	6	0	4	4.0	COc1cccc2c(CCCN3CCN(c4ccccn4)CC3)cccc12	10.1016/j.bmc.2015.05.042
	10047814	104920	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	421	6	0	6	2.7	O=C1c2ccccc2C(=O)N1CCCCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	CHEMBL311015	104920	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	421	6	0	6	2.7	O=C1c2ccccc2C(=O)N1CCCCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	156011408	177516	None	0	Human	Functional	pEC50	=	8.9	8.9	1	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	432	6	0	8	3.2	N#Cc1cccn2c(=O)n(CCCCN3CCN(c4cccc5sccc45)CC3)nc12	10.1016/j.bmcl.2020.127027
	CHEMBL4638430	177516	None	0	Human	Functional	pEC50	=	8.9	8.9	1	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	432	6	0	8	3.2	N#Cc1cccn2c(=O)n(CCCCN3CCN(c4cccc5sccc45)CC3)nc12	10.1016/j.bmcl.2020.127027
	9798593	112899	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	352	8	3	3	3.8	Fc1ccc2[nH]cc(CCCNCCOc3cccc4[nH]cnc34)c2c1	10.1021/jm0304010
	CHEMBL330827	112899	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	352	8	3	3	3.8	Fc1ccc2[nH]cc(CCCNCCOc3cccc4[nH]cnc34)c2c1	10.1021/jm0304010
	9822317	69218	None	2	Human	Functional	pEC50	=	8.8	8.8	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	400	7	1	5	2.6	O=C1c2ccccc2S(=O)(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926761	69218	None	2	Human	Functional	pEC50	=	8.8	8.8	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	400	7	1	5	2.6	O=C1c2ccccc2S(=O)(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	156021344	178274	None	0	Human	Functional	pEC50	=	8.8	8.8	7	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	443	6	0	7	3.6	O=c1n(CCCCN2CCN(c3cccc4sc(F)cc34)CC2)nc2c(F)cccn12	10.1016/j.bmcl.2020.127027
	CHEMBL4649106	178274	None	0	Human	Functional	pEC50	=	8.8	8.8	7	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	443	6	0	7	3.6	O=c1n(CCCCN2CCN(c3cccc4sc(F)cc34)CC2)nc2c(F)cccn12	10.1016/j.bmcl.2020.127027
	145963146	161431	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	478	6	2	5	5.2	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4cccc5c(N)c6c(nc45)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	CHEMBL4125762	161431	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	478	6	2	5	5.2	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4cccc5c(N)c6c(nc45)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	10949698	207745	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Ability to influence the binding of [35S]GTP-gamma-S, to HeLa cell membranes expressing the human 5-hydroxytryptamine 1A receptorAbility to influence the binding of [35S]GTP-gamma-S, to HeLa cell membranes expressing the human 5-hydroxytryptamine 1A receptor	ChEMBL	413	8	1	8	1.9	COc1ccccc1N1CCN(CCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1	10.1021/jm0009336
	CHEMBL79161	207745	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Ability to influence the binding of [35S]GTP-gamma-S, to HeLa cell membranes expressing the human 5-hydroxytryptamine 1A receptorAbility to influence the binding of [35S]GTP-gamma-S, to HeLa cell membranes expressing the human 5-hydroxytryptamine 1A receptor	ChEMBL	413	8	1	8	1.9	COc1ccccc1N1CCN(CCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1	10.1021/jm0009336
	145988038	167272	None	0	Human	Functional	pEC50	=	8.8	8.8	4	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	413	6	0	5	4.0	CC1(C)CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)C(=O)C1	10.1016/j.ejmech.2017.12.099
	CHEMBL4291215	167272	None	0	Human	Functional	pEC50	=	8.8	8.8	4	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	413	6	0	5	4.0	CC1(C)CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)C(=O)C1	10.1016/j.ejmech.2017.12.099
	11232913	113389	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	334	8	3	3	3.6	c1ccc2c(CCCNCCOc3cccc4[nH]cnc34)c[nH]c2c1	10.1021/jm0304010
	CHEMBL331609	113389	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	334	8	3	3	3.6	c1ccc2c(CCCNCCOc3cccc4[nH]cnc34)c[nH]c2c1	10.1021/jm0304010
	145990126	166848	None	0	Human	Functional	pEC50	=	8.8	8.8	2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	425	6	0	5	4.0	O=C1C2CCCCC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4283546	166848	None	0	Human	Functional	pEC50	=	8.8	8.8	2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	425	6	0	5	4.0	O=C1C2CCCCC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	156011945	177532	None	0	Human	Functional	pEC50	=	8.8	8.8	7	5	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	407	6	0	7	3.3	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2ccccn12	10.1016/j.bmcl.2020.127027
	CHEMBL4638599	177532	None	0	Human	Functional	pEC50	=	8.8	8.8	7	5	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	407	6	0	7	3.3	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2ccccn12	10.1016/j.bmcl.2020.127027
	156018107	177970	None	0	Human	Functional	pEC50	=	8.7	8.7	9	6	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	425	6	0	7	3.5	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2c(F)cccn12	10.1016/j.bmcl.2020.127027
	CHEMBL4644352	177970	None	0	Human	Functional	pEC50	=	8.7	8.7	9	6	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	425	6	0	7	3.5	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2c(F)cccn12	10.1016/j.bmcl.2020.127027
	145973003	164629	None	0	Rat	Functional	pEC50	=	8.7	8.7	-	1	Agonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assay	ChEMBL	450	8	0	7	3.9	COc1ccccc1N1CCN(CCCOc2ccc3c(C)cc(=O)oc3c2C(C)=O)CC1	10.1016/j.bmc.2017.12.016
	CHEMBL4215022	164629	None	0	Rat	Functional	pEC50	=	8.7	8.7	-	1	Agonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assay	ChEMBL	450	8	0	7	3.9	COc1ccccc1N1CCN(CCCOc2ccc3c(C)cc(=O)oc3c2C(C)=O)CC1	10.1016/j.bmc.2017.12.016
	11307899	78899	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Binding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-SBinding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-S	ChEMBL	597	6	4	6	2.5	CC(C)C[C@H]1C(=O)N[C@@H](Cc2ccccc2)[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)C(=O)N12	10.1021/jm0341204
	CHEMBL2112882	78899	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Binding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-SBinding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-S	ChEMBL	597	6	4	6	2.5	CC(C)C[C@H]1C(=O)N[C@@H](Cc2ccccc2)[C@]2(O)O[C@@](C)(NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)C(=O)N12	10.1021/jm0341204
	10411236	101432	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	444	6	1	5	4.7	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(-c3cnco3)n2)CC1	10.1021/jm9806906
	CHEMBL297138	101432	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	444	6	1	5	4.7	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(-c3cnco3)n2)CC1	10.1021/jm9806906
	5	139	None	45	Human	Functional	pEC50	=	8	8.0	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2022.114218
	5202	139	None	45	Human	Functional	pEC50	=	8	8.0	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2022.114218
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8	8.0	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2022.114218
	DB08839	139	None	45	Human	Functional	pEC50	=	8	8.0	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2022.114218
	23625537	86511	None	0	Human	Functional	pEC50	=	8	8.0	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	446	6	1	5	4.3	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2nccc(-c3ccco3)n2)CC1	10.1021/jm070714l
	CHEMBL231471	86511	None	0	Human	Functional	pEC50	=	8	8.0	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	446	6	1	5	4.3	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2nccc(-c3ccco3)n2)CC1	10.1021/jm070714l
	15980895	202420	None	0	Human	Functional	pEC50	=	8	8.0	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	439	6	2	3	4.0	CCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2c(F)cc3c(c2C1)C(=O)NCC3	10.1016/j.bmcl.2009.10.134
	CHEMBL595055	202420	None	0	Human	Functional	pEC50	=	8	8.0	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	439	6	2	3	4.0	CCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2c(F)cc3c(c2C1)C(=O)NCC3	10.1016/j.bmcl.2009.10.134
	10248159	83185	None	4	Human	Functional	pEC50	=	8	8.0	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	363	7	1	3	5.1	CC1(C)Cc2cccc(OCCNCc3cccc(C4=CCCC4)c3)c2O1	10.1021/jm061180b
	CHEMBL218261	83185	None	4	Human	Functional	pEC50	=	8	8.0	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	363	7	1	3	5.1	CC1(C)Cc2cccc(OCCNCc3cccc(C4=CCCC4)c3)c2O1	10.1021/jm061180b
	5	139	None	45	Human	Functional	pEC50	=	8	8.0	-33	26	Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00101a032
	5202	139	None	45	Human	Functional	pEC50	=	8	8.0	-33	26	Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00101a032
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8	8.0	-33	26	Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00101a032
	DB08839	139	None	45	Human	Functional	pEC50	=	8	8.0	-33	26	Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00101a032
	10549236	166482	None	0	Human	Functional	pEC50	=	8	8.0	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	404	6	1	4	3.5	CN(C)c1cccc(CNCC2(F)CCN(C(=O)c3cccc(Cl)c3)CC2)n1	10.1021/jm9806906
	CHEMBL42766	166482	None	0	Human	Functional	pEC50	=	8	8.0	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	404	6	1	4	3.5	CN(C)c1cccc(CNCC2(F)CCN(C(=O)c3cccc(Cl)c3)CC2)n1	10.1021/jm9806906
	5	139	None	45	Rat	Functional	pEC50	=	8	8.0	-19	26	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00042a003
	5202	139	None	45	Rat	Functional	pEC50	=	8	8.0	-19	26	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00042a003
	CHEMBL39	139	None	45	Rat	Functional	pEC50	=	8	8.0	-19	26	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00042a003
	DB08839	139	None	45	Rat	Functional	pEC50	=	8	8.0	-19	26	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm00042a003
	42606339	17938	None	0	Human	Functional	pEC50	=	8	8.0	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	397	5	1	4	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3csc4ccccc34)CC2)nc1	10.1021/jm100835q
	CHEMBL1259241	17938	None	0	Human	Functional	pEC50	=	8	8.0	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	397	5	1	4	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3csc4ccccc34)CC2)nc1	10.1021/jm100835q
	137657949	159643	None	0	Human	Functional	pEC50	=	8.0	8.0	2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	420	4	1	7	3.3	Cc1nc2c(O)cccn2c(=O)c1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.bmc.2017.07.040
	CHEMBL4102561	159643	None	0	Human	Functional	pEC50	=	8.0	8.0	2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	420	4	1	7	3.3	Cc1nc2c(O)cccn2c(=O)c1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.bmc.2017.07.040
	129186563	161133	None	0	Human	Functional	pEC50	=	8.0	8.0	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	406	4	0	6	3.5	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCC=C2	10.1016/j.bmc.2017.07.040
	CHEMBL4074326	161133	None	0	Human	Functional	pEC50	=	8.0	8.0	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	406	4	0	6	3.5	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCC=C2	10.1016/j.bmc.2017.07.040
	CHEMBL4116465	161133	None	0	Human	Functional	pEC50	=	8.0	8.0	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	406	4	0	6	3.5	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCC=C2	10.1016/j.bmc.2017.07.040
	137653567	158939	None	0	Human	Functional	pEC50	=	8.0	8.0	-3	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	404	4	0	6	3.6	Cc1nc2ccccn2c(=O)c1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.bmc.2017.07.040
	CHEMBL4094825	158939	None	0	Human	Functional	pEC50	=	8.0	8.0	-3	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	404	4	0	6	3.6	Cc1nc2ccccn2c(=O)c1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.bmc.2017.07.040
	145982353	166680	None	0	Human	Functional	pEC50	=	8.0	8.0	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	457	6	2	7	1.9	O=C1C2CC(O)C(O)CC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4280084	166680	None	0	Human	Functional	pEC50	=	8.0	8.0	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	457	6	2	7	1.9	O=C1C2CC(O)C(O)CC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	145987942	167157	None	0	Human	Functional	pEC50	=	8.0	8.0	-4	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	453	6	0	5	3.8	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sc(F)cc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4289238	167157	None	0	Human	Functional	pEC50	=	8.0	8.0	-4	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	453	6	0	5	3.8	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sc(F)cc23)CC1	10.1016/j.ejmech.2017.12.099
	10789756	174093	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	450	6	1	4	4.3	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(N3CCC3)n2)CC1	10.1021/jm9806906
	CHEMBL45423	174093	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	450	6	1	4	4.3	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(N3CCC3)n2)CC1	10.1021/jm9806906
	1220	187	None	44	Human	Functional	pEC50	=	8.0	8.0	-1	9	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm049493z
	31	187	None	44	Human	Functional	pEC50	=	8.0	8.0	-1	9	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm049493z
	7	187	None	44	Human	Functional	pEC50	=	8.0	8.0	-1	9	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm049493z
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	8.0	8.0	-1	9	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm049493z
	162643462	181836	None	0	Human	Functional	pEC50	=	8.0	8.0	3	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	462	6	0	5	3.9	CN1CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)c2ccccc2C1=O	10.1016/j.ejmech.2020.112572
	CHEMBL4777098	181836	None	0	Human	Functional	pEC50	=	8.0	8.0	3	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	462	6	0	5	3.9	CN1CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)c2ccccc2C1=O	10.1016/j.ejmech.2020.112572
	5	139	None	45	Human	Functional	pEC50	=	8.0	8.0	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins by TR-FRET assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2022.114218
	5202	139	None	45	Human	Functional	pEC50	=	8.0	8.0	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins by TR-FRET assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2022.114218
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.0	8.0	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins by TR-FRET assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2022.114218
	DB08839	139	None	45	Human	Functional	pEC50	=	8.0	8.0	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins by TR-FRET assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2022.114218
	172465729	196945	None	0	Rat	Functional	pEC50	=	7	7.0	83	2	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	607	8	0	5	6.1	CC12C(=O)C(C)(C(c3ccccc3)=C1c1ccccc1)C1C(=O)N(CCCCN3CCN(c4ccccc4Cl)CC3)C(=O)C12	10.1016/j.bmc.2023.117518
	CHEMBL5435378	196945	None	0	Rat	Functional	pEC50	=	7	7.0	83	2	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	607	8	0	5	6.1	CC12C(=O)C(C)(C(c3ccccc3)=C1c1ccccc1)C1C(=O)N(CCCCN3CCN(c4ccccc4Cl)CC3)C(=O)C12	10.1016/j.bmc.2023.117518
	132257061	180133	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	426	7	1	3	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccc(F)cc2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4747425	180133	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	426	7	1	3	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccc(F)cc2)CC1	10.1021/acs.jmedchem.0c00814
	49782389	17876	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	380	5	2	3	3.6	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc4[nH]ccc4c3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259055	17876	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	380	5	2	3	3.6	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc4[nH]ccc4c3)CC2)nc1	10.1021/jm100835q
	15980854	202109	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	465	7	2	3	4.4	O=C1NCCc2cc(F)c3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)CC1CC1)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL592939	202109	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	465	7	2	3	4.4	O=C1NCCc2cc(F)c3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)CC1CC1)CO3	10.1016/j.bmcl.2009.10.134
	127051039	140362	None	0	Human	Functional	pEC50	=	7	7.0	1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	449	9	1	4	4.7	CCNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805772	140362	None	0	Human	Functional	pEC50	=	7	7.0	1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	449	9	1	4	4.7	CCNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	132257265	182215	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	437	8	2	4	4.1	CNc1ccccc1OCCNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4781985	182215	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	437	8	2	4	4.1	CNc1ccccc1OCCNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	138692456	182811	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	407	7	2	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCNc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4789505	182811	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	407	7	2	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCNc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	11288	3418	None	1	Human	Functional	pEC50	=	6.0	6.0	-56	2	Agonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	454	8	3	4	3.7	CCc1cccc(c1Cl)N1CCN(CC1)C[C@@H](CCNC(=O)c1cc2c([nH]1)cccc2)O	10.1021/acs.jmedchem.9b00607
	130431314	3418	None	1	Human	Functional	pEC50	=	6.0	6.0	-56	2	Agonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	454	8	3	4	3.7	CCc1cccc(c1Cl)N1CCN(CC1)C[C@@H](CCNC(=O)c1cc2c([nH]1)cccc2)O	10.1021/acs.jmedchem.9b00607
	CHEMBL4519938	3418	None	1	Human	Functional	pEC50	=	6.0	6.0	-56	2	Agonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	454	8	3	4	3.7	CCc1cccc(c1Cl)N1CCN(CC1)C[C@@H](CCNC(=O)c1cc2c([nH]1)cccc2)O	10.1021/acs.jmedchem.9b00607
	CHEMBL5092918	217884	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6cccc(F)c6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	145987659	167345	None	0	Human	Functional	pEC50	=	7.0	7.0	-3	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	421	5	0	5	3.2	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4292655	167345	None	0	Human	Functional	pEC50	=	7.0	7.0	-3	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	421	5	0	5	3.2	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	155547346	173694	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	449	6	1	4	5.2	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4c5c(nc6ccccc46)CCC5)CC3)c2c1	10.1016/j.bmc.2019.01.025
	CHEMBL4533184	173694	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	449	6	1	4	5.2	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4c5c(nc6ccccc46)CCC5)CC3)c2c1	10.1016/j.bmc.2019.01.025
	6540428	184970	None	1	Human	Functional	pEC50	=	6.0	6.0	37	2	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	nan
	6540428.0	184970	None	1	Human	Functional	pEC50	=	6.0	6.0	37	2	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	nan
	CHEMBL3989558	184970	None	1	Human	Functional	pEC50	=	6.0	6.0	37	2	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	nan
	CHEMBL485253	184970	None	1	Human	Functional	pEC50	=	6.0	6.0	37	2	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	nan
	DB00247	184970	None	1	Human	Functional	pEC50	=	6.0	6.0	37	2	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	353	4	2	4	1.9	CCC(CO)NC(=O)[C@@H]1C=C2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	nan
	53248159	62009	None	0	Human	Functional	pEC50	=	6.0	6.0	-4	2	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	500	8	1	4	5.3	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm200288r
	CHEMBL1774384	62009	None	0	Human	Functional	pEC50	=	6.0	6.0	-4	2	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	500	8	1	4	5.3	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm200288r
	49781933	17929	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	399	5	1	3	4.0	Cc1ccc(CNCC2(F)CCN(C(=O)C34CC5CC(CC(C5)C3)C4)CC2)nc1	10.1021/jm100835q
	CHEMBL1259209	17929	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	399	5	1	3	4.0	Cc1ccc(CNCC2(F)CCN(C(=O)C34CC5CC(CC(C5)C3)C4)CC2)nc1	10.1021/jm100835q
	118626142	165915	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Partial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assayPartial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assay	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4248491	165915	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Partial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assayPartial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assay	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	145976732	163605	None	0	Human	Functional	pEC50	=	8.0	8.0	7	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc4sccc34)CC2)n1	10.1016/j.bmcl.2018.01.038
	CHEMBL4202443	163605	None	0	Human	Functional	pEC50	=	8.0	8.0	7	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc4sccc34)CC2)n1	10.1016/j.bmcl.2018.01.038
	145989183	167326	None	0	Human	Functional	pEC50	=	7.9	7.9	7	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	473	7	0	5	4.4	Cc1ccc(C23CC2C(=O)N(CCCCN2CCN(c4cccc5sccc45)CC2)C3=O)cc1	10.1016/j.ejmech.2017.12.099
	CHEMBL4292254	167326	None	0	Human	Functional	pEC50	=	7.9	7.9	7	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	473	7	0	5	4.4	Cc1ccc(C23CC2C(=O)N(CCCCN2CCN(c4cccc5sccc45)CC2)C3=O)cc1	10.1016/j.ejmech.2017.12.099
	56850665	71529	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	334	7	1	5	2.4	O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926749	71529	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	334	7	1	5	2.4	O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962697	71529	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	334	7	1	5	2.4	O=C1CSC(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	10385855	14430	None	0	Human	Functional	pEC50	=	7.0	7.0	-181	3	Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 110-250Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 110-250	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/0960-894X(95)00091-7
	CHEMBL120055	14430	None	0	Human	Functional	pEC50	=	7.0	7.0	-181	3	Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 110-250Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 110-250	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/0960-894X(95)00091-7
	CHEMBL321818	14430	None	0	Human	Functional	pEC50	=	7.0	7.0	-181	3	Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 110-250Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 110-250	ChEMBL	392	6	2	4	2.7	Cc1ccccc1N1CCN(C(=O)COc2ccc3[nH]cc(CCN)c3c2)CC1	10.1016/0960-894X(95)00091-7
	137630811	161204	None	0	Human	Functional	pEC50	=	6.0	6.0	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	504	6	1	7	4.5	Cc1ccc(Sc2ccccc2N2CCN(CCc3c(C)nc4n(c3=O)CCCC4O)CC2)c(C)c1	10.1016/j.bmc.2017.07.040
	CHEMBL4082150	161204	None	0	Human	Functional	pEC50	=	6.0	6.0	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	504	6	1	7	4.5	Cc1ccc(Sc2ccccc2N2CCN(CCc3c(C)nc4n(c3=O)CCCC4O)CC2)c(C)c1	10.1016/j.bmc.2017.07.040
	CHEMBL4117087	161204	None	0	Human	Functional	pEC50	=	6.0	6.0	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	504	6	1	7	4.5	Cc1ccc(Sc2ccccc2N2CCN(CCc3c(C)nc4n(c3=O)CCCC4O)CC2)c(C)c1	10.1016/j.bmc.2017.07.040
	16109488	84291	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	363	7	1	3	5.1	CC1(C)COc2c(OCCNCc3cccc(C4=CCCC4)c3)cccc21	10.1021/jm061180b
	CHEMBL221183	84291	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	363	7	1	3	5.1	CC1(C)COc2c(OCCNCc3cccc(C4=CCCC4)c3)cccc21	10.1021/jm061180b
	132257069	181162	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	425	7	1	4	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCSc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4759629	181162	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	425	7	1	4	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCSc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	9928161	75946	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	345	3	2	3	4.1	C1=C(c2c[nH]c3ccccc23)CCN(CC2CNc3ccccc3O2)C1	10.1016/j.bmcl.2005.11.054
	CHEMBL205031	75946	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	345	3	2	3	4.1	C1=C(c2c[nH]c3ccccc23)CCN(CC2CNc3ccccc3O2)C1	10.1016/j.bmcl.2005.11.054
	45483512	200675	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay	ChEMBL	287	3	1	2	4.6	Clc1cccc(Oc2ccccc2C2CCNCC2)c1	10.1016/j.bmcl.2009.10.014
	CHEMBL575290	200675	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay	ChEMBL	287	3	1	2	4.6	Clc1cccc(Oc2ccccc2C2CCNCC2)c1	10.1016/j.bmcl.2009.10.014
	9799764	88375	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	375	5	2	3	4.4	Fc1ccc2[nH]cc(CCCNC3COc4ccc5ncccc5c4C3)c2c1	10.1016/j.bmcl.2007.03.049
	CHEMBL234853	88375	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	375	5	2	3	4.4	Fc1ccc2[nH]cc(CCCNC3COc4ccc5ncccc5c4C3)c2c1	10.1016/j.bmcl.2007.03.049
	145965041	164350	None	0	Human	Functional	pEC50	=	6.9	6.9	3	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cccc(OCCCCN2CCN(c3ccc4ccsc4c3)CC2)n1	10.1016/j.bmcl.2018.01.038
	CHEMBL4211473	164350	None	0	Human	Functional	pEC50	=	6.9	6.9	3	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cccc(OCCCCN2CCN(c3ccc4ccsc4c3)CC2)n1	10.1016/j.bmcl.2018.01.038
	130431317	173053	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	455	8	2	5	4.0	CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl	10.1021/acs.jmedchem.6b00860
	CHEMBL4517102	173053	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	455	8	2	5	4.0	CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl	10.1021/acs.jmedchem.6b00860
	155510732	169623	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	2	Agonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assay	ChEMBL	430	6	1	1	6.9	Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126703
	CHEMBL4434876	169623	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	2	Agonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assay	ChEMBL	430	6	1	1	6.9	Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1	10.1016/j.bmcl.2019.126703
	11667626	102639	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Partial agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAPartial agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	359	10	1	4	2.4	CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL2431042	102639	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Partial agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAPartial agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	359	10	1	4	2.4	CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL3040827	102639	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Partial agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAPartial agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	359	10	1	4	2.4	CCc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	127049163	140311	None	0	Human	Functional	pEC50	=	7.9	7.9	-2	2	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	8	1	6	3.3	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc4c3OC(F)(F)O4)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805165	140311	None	0	Human	Functional	pEC50	=	7.9	7.9	-2	2	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	8	1	6	3.3	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc4c3OC(F)(F)O4)CC2)c1	10.1016/j.bmcl.2016.04.087
	42606222	17867	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	347	5	1	4	3.2	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccsc3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259033	17867	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	347	5	1	4	3.2	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccsc3)CC2)nc1	10.1021/jm100835q
	1220	187	None	44	Human	Functional	pEC50	=	7.9	7.9	-1	9	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2015.05.042
	31	187	None	44	Human	Functional	pEC50	=	7.9	7.9	-1	9	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2015.05.042
	7	187	None	44	Human	Functional	pEC50	=	7.9	7.9	-1	9	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2015.05.042
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	7.9	7.9	-1	9	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2015.05.042
	10719425	100247	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	477	6	1	4	5.9	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3cccs3)n2)CC1	10.1021/jm9806906
	CHEMBL288244	100247	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	477	6	1	4	5.9	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3cccs3)n2)CC1	10.1021/jm9806906
	156013716	177385	None	0	Human	Functional	pEC50	=	7.9	7.9	7	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	441	6	0	7	4.0	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2c(Cl)cccn12	10.1016/j.bmcl.2020.127027
	CHEMBL4636321	177385	None	0	Human	Functional	pEC50	=	7.9	7.9	7	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	441	6	0	7	4.0	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2c(Cl)cccn12	10.1016/j.bmcl.2020.127027
	10718220	169414	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	445	6	1	5	3.8	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2cccc(-n3cccn3)n2)CC1	10.1021/jm9806906
	CHEMBL44159	169414	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	445	6	1	5	3.8	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2cccc(-n3cccn3)n2)CC1	10.1021/jm9806906
	11795765	173706	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	408	6	2	4	3.7	CNc1cccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)n1	10.1021/jm9806906
	CHEMBL45334	173706	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	408	6	2	4	3.7	CNc1cccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)n1	10.1021/jm9806906
	44461162	208009	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	413	7	1	5	2.9	O=C(NCCCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL81095	208009	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	413	7	1	5	2.9	O=C(NCCCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	145972513	164601	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	443	8	1	7	3.2	CNC(=O)c1cccc(OCCCCN2CCN(c3nsc4cc(F)ccc34)CC2)n1	10.1016/j.bmcl.2018.01.038
	CHEMBL4214642	164601	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	443	8	1	7	3.2	CNC(=O)c1cccc(OCCCCN2CCN(c3nsc4cc(F)ccc34)CC2)n1	10.1016/j.bmcl.2018.01.038
	127048533	140338	None	0	Human	Functional	pEC50	=	6.9	6.9	1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	465	9	1	5	4.3	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1OC	10.1016/j.bmcl.2016.04.087
	CHEMBL3805515	140338	None	0	Human	Functional	pEC50	=	6.9	6.9	1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	465	9	1	5	4.3	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1OC	10.1016/j.bmcl.2016.04.087
	152215	97051	None	42	Human	Functional	pEC50	=	4.9	4.9	-	1	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	212	1	1	1	2.9	CN1CC=C(c2c[nH]c3ccccc23)CC1	nan
	CHEMBL26655	97051	None	42	Human	Functional	pEC50	=	4.9	4.9	-	1	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	212	1	1	1	2.9	CN1CC=C(c2c[nH]c3ccccc23)CC1	nan
	168281650	191311	None	0	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assayAgonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assay	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)cc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5189417	191311	None	0	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assayAgonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assay	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)cc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	44578448	183020	None	0	Rat	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding	ChEMBL	433	6	1	9	1.8	CCC1=CC2C(=O)N(N)C(SCCCN3CCN(c4ncccn4)CC3)=NC2S1	10.1021/jm800176x
	CHEMBL479243	183020	None	0	Rat	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding	ChEMBL	433	6	1	9	1.8	CCC1=CC2C(=O)N(N)C(SCCCN3CCN(c4ncccn4)CC3)=NC2S1	10.1021/jm800176x
	127049861	140327	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	435	8	1	4	4.3	CNC(=O)c1ccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805376	140327	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	435	8	1	4	4.3	CNC(=O)c1ccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmcl.2016.04.087
	127049516	140390	None	0	Human	Functional	pEC50	=	6.9	6.9	6	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	449	8	1	4	4.6	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C	10.1016/j.bmcl.2016.04.087
	CHEMBL3806091	140390	None	0	Human	Functional	pEC50	=	6.9	6.9	6	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	449	8	1	4	4.6	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C	10.1016/j.bmcl.2016.04.087
	CHEMBL5070726	216730	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4cccc(C(=O)CCC5CCN(Cc6ccccc6)CC5)c4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	56850658	71544	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	371	7	1	4	1.6	O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926745	71544	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	371	7	1	4	1.6	O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962804	71544	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	371	7	1	4	1.6	O=C1C2CCCN2C(=O)CN1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL5088314	217642	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		COc1cccc(CN2CCC(CCC(=O)c3ccc(N4CCN(CCCCc5c[nH]c6ccc(C#N)cc56)CC4)cc3)CC2)c1	10.1016/j.ejmech.2021.114045
	168295269	192621	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assay	ChEMBL	463	7	0	8	3.3	COc1cccc(N2CCN(CC3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)CC2)c1	10.1016/j.ejmech.2022.114218
	CHEMBL5209272	192621	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assay	ChEMBL	463	7	0	8	3.3	COc1cccc(N2CCN(CC3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)CC2)c1	10.1016/j.ejmech.2022.114218
	145969406	164924	None	0	Rat	Functional	pEC50	=	6.9	6.9	-	1	Antagonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes assessed as inhibition of 8-OH-DPAT-induced receptor activation after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assayAntagonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes assessed as inhibition of 8-OH-DPAT-induced receptor activation after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assay	ChEMBL	498	7	0	6	4.7	CC(=O)c1c(OCCCN2CCN(c3ccccc3Br)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.bmc.2017.12.016
	CHEMBL4218720	164924	None	0	Rat	Functional	pEC50	=	6.9	6.9	-	1	Antagonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes assessed as inhibition of 8-OH-DPAT-induced receptor activation after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assayAntagonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes assessed as inhibition of 8-OH-DPAT-induced receptor activation after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assay	ChEMBL	498	7	0	6	4.7	CC(=O)c1c(OCCCN2CCN(c3ccccc3Br)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.bmc.2017.12.016
	3658	4107	None	38	Human	Functional	pEC50	=	6.9	6.9	-5	18	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	nan
	517	4107	None	38	Human	Functional	pEC50	=	6.9	6.9	-5	18	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	nan
	5709	4107	None	38	Human	Functional	pEC50	=	6.9	6.9	-5	18	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	nan
	5709.0	4107	None	38	Human	Functional	pEC50	=	6.9	6.9	-5	18	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	nan
	CHEMBL312448	4107	None	38	Human	Functional	pEC50	=	6.9	6.9	-5	18	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	nan
	DB06694	4107	None	38	Human	Functional	pEC50	=	6.9	6.9	-5	18	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	nan
	127049863	140339	None	0	Human	Functional	pEC50	=	7.9	7.9	1	6	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	443	8	1	5	4.5	CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
	CHEMBL3805518	140339	None	0	Human	Functional	pEC50	=	7.9	7.9	1	6	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	443	8	1	5	4.5	CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
	127049862	140344	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	6	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	425	8	1	5	4.4	CNC(=O)c1cccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805559	140344	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	6	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	425	8	1	5	4.4	CNC(=O)c1cccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1	10.1016/j.bmcl.2016.04.087
	11381753	78800	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	324	9	2	3	3.8	COc1ccccc1OCCNCCCc1c[nH]c2ccccc12	10.1021/jm0304010
	CHEMBL2112645	78800	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	324	9	2	3	3.8	COc1ccccc1OCCNCCCc1c[nH]c2ccccc12	10.1021/jm0304010
	49780599	17910	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	341	5	1	3	3.1	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccccc3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259151	17910	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	341	5	1	3	3.1	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccccc3)CC2)nc1	10.1021/jm100835q
	10812183	100330	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	422	7	2	4	4.0	CCNc1cccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)n1	10.1021/jm9806906
	CHEMBL288992	100330	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	422	7	2	4	4.0	CCNc1cccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)n1	10.1021/jm9806906
	145984151	166542	None	0	Human	Functional	pEC50	=	7.9	7.9	16	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	437	6	0	5	4.2	O=C1c2ccc(F)cc2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4277751	166542	None	0	Human	Functional	pEC50	=	7.9	7.9	16	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	437	6	0	5	4.2	O=C1c2ccc(F)cc2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	132256724	180853	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	459	7	1	4	4.6	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3cccnc23)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4756041	180853	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	459	7	1	4	4.6	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3cccnc23)CC1	10.1021/acs.jmedchem.0c00814
	23155650	18668	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting	ChEMBL	446	6	1	7	2.8	Cc1cc(N2CCN(CCCCc3nc4c(c(=O)n3N)CCCC4)CC2)nc2ccccc12	10.1021/jm1002292
	CHEMBL1277007	18668	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting	ChEMBL	446	6	1	7	2.8	Cc1cc(N2CCN(CCCCc3nc4c(c(=O)n3N)CCCC4)CC2)nc2ccccc12	10.1021/jm1002292
	145991746	166947	None	0	Human	Functional	pEC50	=	7.9	7.9	6	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	407	4	0	5	2.8	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4285479	166947	None	0	Human	Functional	pEC50	=	7.9	7.9	6	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	407	4	0	5	2.8	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	42606340	17896	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	403	5	1	5	4.4	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc4sccc4s3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259108	17896	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	403	5	1	5	4.4	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc4sccc4s3)CC2)nc1	10.1021/jm100835q
	137635294	156183	None	0	Human	Functional	pEC50	=	5.9	5.9	-245	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	445	4	0	7	3.4	Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2(F)F	10.1016/j.bmc.2017.07.040
	CHEMBL4062992	156183	None	0	Human	Functional	pEC50	=	5.9	5.9	-245	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	445	4	0	7	3.4	Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2(F)F	10.1016/j.bmc.2017.07.040
	2543	3707	None	46	Rat	Functional	pEC50	=	5.9	5.9	-19	14	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
	5358	3707	None	46	Rat	Functional	pEC50	=	5.9	5.9	-19	14	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
	5358.0	3707	None	46	Rat	Functional	pEC50	=	5.9	5.9	-19	14	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
	54	3707	None	46	Rat	Functional	pEC50	=	5.9	5.9	-19	14	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
	CHEMBL128	3707	None	46	Rat	Functional	pEC50	=	5.9	5.9	-19	14	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
	DB00669	3707	None	46	Rat	Functional	pEC50	=	5.9	5.9	-19	14	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00042a003
	132256814	180624	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	454	8	1	4	4.6	COc1ccc(OCCNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)cc1	10.1021/acs.jmedchem.0c00814
	CHEMBL4753394	180624	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	454	8	1	4	4.6	COc1ccc(OCCNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)cc1	10.1021/acs.jmedchem.0c00814
	53248208	62010	None	0	Human	Functional	pEC50	=	6.9	6.9	3	2	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	425	8	1	5	3.7	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm200288r
	CHEMBL1774385	62010	None	0	Human	Functional	pEC50	=	6.9	6.9	3	2	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	425	8	1	5	3.7	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm200288r
	16109510	169409	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	337	7	1	4	4.2	C1=C(c2cccc(CNCCOc3cccc4c3OCO4)c2)CCC1	10.1021/jm061180b
	CHEMBL441546	169409	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	337	7	1	4	4.2	C1=C(c2cccc(CNCCOc3cccc4c3OCO4)c2)CCC1	10.1021/jm061180b
	9932697	141065	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	435	6	1	4	5.1	CCCN1CC(CN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)Oc2c(OC)cccc21	10.1016/j.bmcl.2005.11.054
	CHEMBL382333	141065	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	435	6	1	4	5.1	CCCN1CC(CN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)Oc2c(OC)cccc21	10.1016/j.bmcl.2005.11.054
	3246443	37697	None	0	Human	Functional	pEC50	=	4.9	4.9	-13	3	Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	CHEMBL1457510	37697	None	0	Human	Functional	pEC50	=	4.9	4.9	-13	3	Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	127049849	140333	None	0	Human	Functional	pEC50	=	6.9	6.9	-3	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	477	9	1	5	4.5	CNC(=O)c1cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(C(C)=O)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805434	140333	None	0	Human	Functional	pEC50	=	6.9	6.9	-3	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	477	9	1	5	4.5	CNC(=O)c1cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(C(C)=O)c1	10.1016/j.bmcl.2016.04.087
	45375938	200492	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay	ChEMBL	289	3	1	2	4.2	Fc1cccc(Oc2cccc(F)c2C2CCNCC2)c1	10.1016/j.bmcl.2009.10.014
	CHEMBL574004	200492	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay	ChEMBL	289	3	1	2	4.2	Fc1cccc(Oc2cccc(F)c2C2CCNCC2)c1	10.1016/j.bmcl.2009.10.014
	44591228	179414	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	361	6	2	4	4.0	c1ccc2c(CCN3CCCC(c4ccnc(NC5CC5)n4)C3)c[nH]c2c1	10.1016/j.bmcl.2008.12.087
	CHEMBL473282	179414	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	361	6	2	4	4.0	c1ccc2c(CCN3CCCC(c4ccnc(NC5CC5)n4)C3)c[nH]c2c1	10.1016/j.bmcl.2008.12.087
	132247311	181246	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	451	8	1	4	4.2	CN(C)c1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4760666	181246	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	451	8	1	4	4.2	CN(C)c1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	2998814	55038	None	0	Human	Functional	pEC50	=	4.9	4.9	-	1	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	245	1	1	2	1.8	C[N+]1=C2CCCCCN2C(O)(c2ccccc2)C1	nan
	CHEMBL1301276	55038	None	0	Human	Functional	pEC50	=	4.9	4.9	-	1	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	245	1	1	2	1.8	C[N+]1=C2CCCCCN2C(O)(c2ccccc2)C1	nan
	CHEMBL1616268	55038	None	0	Human	Functional	pEC50	=	4.9	4.9	-	1	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	245	1	1	2	1.8	C[N+]1=C2CCCCCN2C(O)(c2ccccc2)C1	nan
	9909555	140778	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	411	8	2	3	5.2	c1ccc(CN2CC(CNCCCc3c[nH]c4ccccc34)Oc3ccccc32)cc1	10.1016/j.bmcl.2005.11.054
	CHEMBL381542	140778	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	411	8	2	3	5.2	c1ccc(CN2CC(CNCCCc3c[nH]c4ccccc34)Oc3ccccc32)cc1	10.1016/j.bmcl.2005.11.054
	15057516	155992	None	0	Human	Functional	pEC50	=	5.9	5.9	-269	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	425	4	1	8	2.4	Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	CHEMBL4060678	155992	None	0	Human	Functional	pEC50	=	5.9	5.9	-269	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	425	4	1	8	2.4	Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	10550893	166536	None	0	Human	Functional	pEC50	=	7.9	7.9	-3	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	436	6	0	6	3.0	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4277532	166536	None	0	Human	Functional	pEC50	=	7.9	7.9	-3	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	436	6	0	6	3.0	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2nsc3ccccc23)CC1	10.1016/j.ejmech.2017.12.099
	1220	187	None	44	Rat	Functional	pEC50	=	7.9	7.9	1	9	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2023.117518
	31	187	None	44	Rat	Functional	pEC50	=	7.9	7.9	1	9	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2023.117518
	7	187	None	44	Rat	Functional	pEC50	=	7.9	7.9	1	9	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2023.117518
	CHEMBL56	187	None	44	Rat	Functional	pEC50	=	7.9	7.9	1	9	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmc.2023.117518
	132247301	180875	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	447	7	2	3	4.6	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3[nH]ccc23)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4756233	180875	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	447	7	2	3	4.6	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3[nH]ccc23)CC1	10.1021/acs.jmedchem.0c00814
	132256713	182576	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	407	7	1	3	4.0	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCCc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4786537	182576	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	407	7	1	3	4.0	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCCc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	132256749	181239	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	422	7	1	3	4.4	Cc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4760621	181239	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	422	7	1	3	4.4	Cc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	21797090	106814	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	503	11	1	7	5.2	S=c1[nH]ncn1[C@@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H]1OCc1ccccc1	10.1021/jm9806906
	CHEMBL3144354	106814	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	503	11	1	7	5.2	S=c1[nH]ncn1[C@@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H]1OCc1ccccc1	10.1021/jm9806906
	10647621	163744	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	459	6	1	5	4.1	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1-n1cccn1	10.1021/jm9806906
	CHEMBL42042	163744	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	459	6	1	5	4.1	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1-n1cccn1	10.1021/jm9806906
	145963710	161716	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	478	6	2	5	5.2	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5nc6c(c(N)c5c4)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	CHEMBL4129917	161716	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	478	6	2	5	5.2	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5nc6c(c(N)c5c4)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	44591230	180416	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	389	7	2	4	4.6	CC(Nc1nccc(C2CCCN(CCc3c[nH]c4ccccc34)C2)n1)C1CC1	10.1016/j.bmcl.2008.12.087
	CHEMBL475105	180416	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	389	7	2	4	4.6	CC(Nc1nccc(C2CCCN(CCc3c[nH]c4ccccc34)C2)n1)C1CC1	10.1016/j.bmcl.2008.12.087
	16109481	83178	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	361	9	1	3	5.3	CC(C)Oc1ccccc1OCCNCc1cccc(-c2ccccc2)c1	10.1021/jm061180b
	CHEMBL218217	83178	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	361	9	1	3	5.3	CC(C)Oc1ccccc1OCCNCc1cccc(-c2ccccc2)c1	10.1021/jm061180b
	53248212	62053	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	424	8	2	4	3.5	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm200288r
	CHEMBL1774534	62053	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	424	8	2	4	3.5	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm200288r
	145962678	161730	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	492	6	2	5	5.6	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4cccc5nc6c(c(N)c45)CCCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	CHEMBL4130059	161730	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	492	6	2	5	5.6	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4cccc5nc6c(c(N)c45)CCCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	135453290	133675	None	29	Human	Functional	pEC50	=	5.8	5.8	-724	7	Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP productionAgonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP production	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL371300	133675	None	29	Human	Functional	pEC50	=	5.8	5.8	-724	7	Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP productionAgonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP production	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	5	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-33	26	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm9015763
	5202	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-33	26	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm9015763
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-33	26	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm9015763
	DB08839	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-33	26	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm9015763
	44591229	189806	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	375	7	2	4	4.2	c1ccc2c(CCN3CCCC(c4ccnc(NCC5CC5)n4)C3)c[nH]c2c1	10.1016/j.bmcl.2008.12.087
	CHEMBL515438	189806	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	375	7	2	4	4.2	c1ccc2c(CCN3CCCC(c4ccnc(NCC5CC5)n4)C3)c[nH]c2c1	10.1016/j.bmcl.2008.12.087
	132256749	181239	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	422	7	1	3	4.4	Cc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4760621	181239	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	422	7	1	3	4.4	Cc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	130431337	174191	None	0	Human	Functional	pEC50	=	6.8	6.8	-15	2	Agonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	438	8	2	3	4.7	CCc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl	10.1021/acs.jmedchem.6b00860
	CHEMBL4544583	174191	None	0	Human	Functional	pEC50	=	6.8	6.8	-15	2	Agonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	438	8	2	3	4.7	CCc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl	10.1021/acs.jmedchem.6b00860
	1220	187	None	44	Human	Functional	pEC50	=	7.8	7.8	-1	9	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2012.11.042
	31	187	None	44	Human	Functional	pEC50	=	7.8	7.8	-1	9	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2012.11.042
	7	187	None	44	Human	Functional	pEC50	=	7.8	7.8	-1	9	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2012.11.042
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	7.8	7.8	-1	9	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2012.11.042
	42606459	17868	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	331	5	1	4	2.7	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccco3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259034	17868	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	331	5	1	4	2.7	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccco3)CC2)nc1	10.1021/jm100835q
	132257265	182215	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	437	8	2	4	4.1	CNc1ccccc1OCCNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4781985	182215	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	437	8	2	4	4.1	CNc1ccccc1OCCNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	9885700	163457	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	370	8	2	4	3.7	Fc1ccc2[nH]cc(CCCNCCOc3cccc4c3OCCO4)c2c1	10.1021/jm0304010
	CHEMBL419240	163457	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	370	8	2	4	3.7	Fc1ccc2[nH]cc(CCCNCCOc3cccc4c3OCCO4)c2c1	10.1021/jm0304010
	138692460	179501	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	426	7	1	3	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(F)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4739908	179501	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	426	7	1	3	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(F)c2)CC1	10.1021/acs.jmedchem.0c00814
	5	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-33	26	Agonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2009.06.019
	5202	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-33	26	Agonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2009.06.019
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-33	26	Agonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2009.06.019
	DB08839	139	None	45	Human	Functional	pEC50	=	6.8	6.8	-33	26	Agonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2009.06.019
	11291892	133582	None	3	Human	Functional	pEC50	=	6.8	6.8	-	1	Inhibition of forskolin-induced increase in cAMP in human 5-hydroxytryptamine 1A receptor expressed HeLa cellsInhibition of forskolin-induced increase in cAMP in human 5-hydroxytryptamine 1A receptor expressed HeLa cells	ChEMBL	378	3	0	4	1.8	O=C1[C@@H]2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm048999e
	CHEMBL370758	133582	None	3	Human	Functional	pEC50	=	6.8	6.8	-	1	Inhibition of forskolin-induced increase in cAMP in human 5-hydroxytryptamine 1A receptor expressed HeLa cellsInhibition of forskolin-induced increase in cAMP in human 5-hydroxytryptamine 1A receptor expressed HeLa cells	ChEMBL	378	3	0	4	1.8	O=C1[C@@H]2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1	10.1021/jm048999e
	172445107	195412	None	0	Rat	Functional	pEC50	=	5.8	5.8	14	2	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	575	8	0	7	4.2	CC12C(=O)C(C)(C(c3ccccc3)=C1c1ccccc1)C1C(=O)N(CCCCN3CCN(c4ncccn4)CC3)C(=O)C12	10.1016/j.bmc.2023.117518
	CHEMBL5403228	195412	None	0	Rat	Functional	pEC50	=	5.8	5.8	14	2	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	575	8	0	7	4.2	CC12C(=O)C(C)(C(c3ccccc3)=C1c1ccccc1)C1C(=O)N(CCCCN3CCN(c4ncccn4)CC3)C(=O)C12	10.1016/j.bmc.2023.117518
	71574204	86301	None	0	Human	Functional	pEC50	=	4.8	4.8	-18	2	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
	CHEMBL2312640	86301	None	0	Human	Functional	pEC50	=	4.8	4.8	-18	2	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12	10.1016/j.ejmech.2012.11.042
	132257139	181218	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	426	7	1	3	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2F)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4760271	181218	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	426	7	1	3	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2F)CC1	10.1021/acs.jmedchem.0c00814
	23625383	86314	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	414	5	1	4	3.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2ncc(Cl)cn2)CC1	10.1021/jm070714l
	CHEMBL231273	86314	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	414	5	1	4	3.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2ncc(Cl)cn2)CC1	10.1021/jm070714l
	16109508	84421	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	379	9	1	3	6.0	CC(C)Oc1ccccc1OCCNCc1cccc(C2=CCCCCC2)c1	10.1021/jm061180b
	CHEMBL221957	84421	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	379	9	1	3	6.0	CC(C)Oc1ccccc1OCCNCc1cccc(C2=CCCCCC2)c1	10.1021/jm061180b
	44408946	159663	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	325	5	3	3	3.3	Fc1ccc2[nH]cc(CCNCC3CNc4ccccc4O3)c2c1	10.1016/j.bmcl.2005.11.054
	CHEMBL410273	159663	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	325	5	3	3	3.3	Fc1ccc2[nH]cc(CCNCC3CNc4ccccc4O3)c2c1	10.1016/j.bmcl.2005.11.054
	71574306	86300	None	0	Human	Functional	pEC50	=	4.8	4.8	-2	2	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312639	86300	None	0	Human	Functional	pEC50	=	4.8	4.8	-2	2	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1016/j.ejmech.2012.11.042
	145960879	161546	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	492	6	2	6	4.8	N#Cc1ccc2[nH]cc(C(=O)CCCN3CCN(c4ccc5nc6c(c(N)c5c4)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	CHEMBL4127445	161546	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	492	6	2	6	4.8	N#Cc1ccc2[nH]cc(C(=O)CCCN3CCN(c4ccc5nc6c(c(N)c5c4)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	56850796	71556	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	371	8	1	4	2.6	O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926686	71556	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	371	8	1	4	2.6	O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962913	71556	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	371	8	1	4	2.6	O=C1C2CCCN2C(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	168355520	196760	None	2	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	395	7	2	4	3.0	O=C(NCCCCN1CCN(c2ccc(F)cc2)CC1)c1n[nH]c2ccccc12	10.1016/j.ejmech.2023.115285
	CHEMBL5431642	196760	None	2	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	395	7	2	4	3.0	O=C(NCCCCN1CCN(c2ccc(F)cc2)CC1)c1n[nH]c2ccccc12	10.1016/j.ejmech.2023.115285
	42606573	17853	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	381	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3coc4ccccc34)CC2)nc1	10.1021/jm100835q
	CHEMBL1258999	17853	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	381	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3coc4ccccc34)CC2)nc1	10.1021/jm100835q
	56850390	71508	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926733	71508	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962486	71508	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	357	7	1	4	2.2	O=C1C2CCCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	145968927	164862	None	0	Human	Functional	pEC50	=	7.8	7.8	2	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	411	8	1	7	2.8	NC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4217986	164862	None	0	Human	Functional	pEC50	=	7.8	7.8	2	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	411	8	1	7	2.8	NC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	137629633	161228	None	0	Human	Functional	pEC50	=	7.8	7.8	2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	432	4	0	7	2.6	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4c3OC(F)(F)O4)CC1)CCCC2	10.1016/j.bmc.2017.07.040
	CHEMBL4077006	161228	None	0	Human	Functional	pEC50	=	7.8	7.8	2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	432	4	0	7	2.6	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4c3OC(F)(F)O4)CC1)CCCC2	10.1016/j.bmc.2017.07.040
	CHEMBL4117235	161228	None	0	Human	Functional	pEC50	=	7.8	7.8	2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	432	4	0	7	2.6	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4c3OC(F)(F)O4)CC1)CCCC2	10.1016/j.bmc.2017.07.040
	132247311	181246	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	451	8	1	4	4.2	CN(C)c1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4760666	181246	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	451	8	1	4	4.2	CN(C)c1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	168355520	196760	None	2	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	395	7	2	4	3.0	O=C(NCCCCN1CCN(c2ccc(F)cc2)CC1)c1n[nH]c2ccccc12	10.1016/j.ejmech.2023.115285
	CHEMBL5431642	196760	None	2	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	395	7	2	4	3.0	O=C(NCCCCN1CCN(c2ccc(F)cc2)CC1)c1n[nH]c2ccccc12	10.1016/j.ejmech.2023.115285
	CHEMBL5086036	217497	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccsc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	CHEMBL5089630	217708	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccc(F)cc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	10528303	101444	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	468	6	1	6	4.1	N#CC1(CNCc2cccc(-n3cccn3)n2)CCN(C(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm9806906
	CHEMBL297208	101444	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	468	6	1	6	4.1	N#CC1(CNCc2cccc(-n3cccn3)n2)CCN(C(=O)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm9806906
	25130235	187693	None	1	Human	Functional	pEC50	=	5.8	5.8	-13	3	Agonist activity at 5HT1A receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by GTPgammaS binding assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	CHEMBL494678	187693	None	1	Human	Functional	pEC50	=	5.8	5.8	-13	3	Agonist activity at 5HT1A receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by GTPgammaS binding assay	ChEMBL	294	2	1	6	1.3	CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1	10.1021/jm8005959
	71574212	86318	None	0	Human	Functional	pEC50	=	5.8	5.8	4	2	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312935	86318	None	0	Human	Functional	pEC50	=	5.8	5.8	4	2	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1	10.1016/j.ejmech.2012.11.042
	44408888	138792	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	339	5	2	3	3.3	CN1CC(CNCCc2c[nH]c3ccc(F)cc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	CHEMBL377941	138792	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	339	5	2	3	3.3	CN1CC(CNCCc2c[nH]c3ccc(F)cc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	CHEMBL5085109	217439	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc(N2CCN(CCCCc3c[nH]c4ccc(Br)cc34)CC2)cc1	10.1016/j.ejmech.2021.114045
	44591246	179487	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	379	6	2	4	4.1	Fc1ccc2[nH]cc(CCN3CCCC(c4ccnc(NC5CC5)n4)C3)c2c1	10.1016/j.bmcl.2008.12.087
	CHEMBL473903	179487	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	379	6	2	4	4.1	Fc1ccc2[nH]cc(CCN3CCCC(c4ccnc(NC5CC5)n4)C3)c2c1	10.1016/j.bmcl.2008.12.087
	122183764	122299	None	0	Human	Functional	pEC50	=	7.8	7.8	1	3	Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	454	7	2	5	3.7	O=C(NCCC(O)CN1CCN(c2cccc3ccccc23)CC1)c1cnc2ccccc2c1	10.1021/acs.jmedchem.5b00776
	CHEMBL3597636	122299	None	0	Human	Functional	pEC50	=	7.8	7.8	1	3	Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	454	7	2	5	3.7	O=C(NCCC(O)CN1CCN(c2cccc3ccccc23)CC1)c1cnc2ccccc2c1	10.1021/acs.jmedchem.5b00776
	42605994	17881	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	425	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc(Br)cs3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259071	17881	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	425	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc(Br)cs3)CC2)nc1	10.1021/jm100835q
	132256735	180616	None	13	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	409	7	1	4	3.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4753328	180616	None	13	Human	Functional	pEC50	=	7.8	7.8	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	409	7	1	4	3.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	145978965	166653	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	469	6	2	7	1.8	O=C1[C@@H]2[C@H](C(=O)N1CCCCN1CCN(c3cccc4sccc34)CC1)[C@@H]1C[C@H]2[C@@H](O)[C@H]1O	10.1016/j.ejmech.2017.12.099
	CHEMBL4279645	166653	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	469	6	2	7	1.8	O=C1[C@@H]2[C@H](C(=O)N1CCCCN1CCN(c3cccc4sccc34)CC1)[C@@H]1C[C@H]2[C@@H](O)[C@H]1O	10.1016/j.ejmech.2017.12.099
	145967359	164276	None	0	Human	Functional	pEC50	=	7.8	7.8	2	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	440	9	1	6	4.2	CCNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4210637	164276	None	0	Human	Functional	pEC50	=	7.8	7.8	2	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	440	9	1	6	4.2	CCNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL5078724	217069	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		Cc1cccc(CN2CCC(CCC(=O)c3ccc(N4CCN(CCCCc5c[nH]c6ccc(C#N)cc56)CC4)cc3)CC2)c1	10.1016/j.ejmech.2021.114045
	10381677	106619	None	0	Rat	Functional	pEC50	=	6.8	6.8	-24	2	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	325	6	2	5	3.3	CN(C)CCc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12	10.1021/jm00042a003
	CHEMBL314213	106619	None	0	Rat	Functional	pEC50	=	6.8	6.8	-24	2	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	325	6	2	5	3.3	CN(C)CCc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12	10.1021/jm00042a003
	172442572	195028	None	0	Rat	Functional	pEC50	=	5.8	5.8	10	2	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	591	8	0	5	5.5	CC12C(=O)C(C)(C(c3ccccc3)=C1c1ccccc1)C1C(=O)N(CCCCN3CCN(c4ccccc4F)CC3)C(=O)C12	10.1016/j.bmc.2023.117518
	CHEMBL5395179	195028	None	0	Rat	Functional	pEC50	=	5.8	5.8	10	2	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	591	8	0	5	5.5	CC12C(=O)C(C)(C(c3ccccc3)=C1c1ccccc1)C1C(=O)N(CCCCN3CCN(c4ccccc4F)CC3)C(=O)C12	10.1016/j.bmc.2023.117518
	11188024	145669	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	375	5	2	3	4.4	Fc1ccc2[nH]cc(CCCNC3COc4c(ccc5ncccc45)C3)c2c1	10.1016/j.bmcl.2007.03.049
	CHEMBL391531	145669	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	375	5	2	3	4.4	Fc1ccc2[nH]cc(CCCNC3COc4c(ccc5ncccc45)C3)c2c1	10.1016/j.bmcl.2007.03.049
	162642953	181844	None	0	Human	Functional	pEC50	=	6.8	6.8	2	3	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	445	8	0	3	5.1	O=C(c1ccccc1)N(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)CC1CC1	10.1016/j.ejmech.2020.112214
	CHEMBL4777207	181844	None	0	Human	Functional	pEC50	=	6.8	6.8	2	3	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	445	8	0	3	5.1	O=C(c1ccccc1)N(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)CC1CC1	10.1016/j.ejmech.2020.112214
	CHEMBL5082850	217316	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6cccc(Br)c6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	145974143	164631	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	443	8	1	7	3.2	CNC(=O)c1ccnc(OCCCCN2CCN(c3nsc4cc(F)ccc34)CC2)c1	10.1016/j.bmcl.2018.01.038
	CHEMBL4215048	164631	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	443	8	1	7	3.2	CNC(=O)c1ccnc(OCCCCN2CCN(c3nsc4cc(F)ccc34)CC2)c1	10.1016/j.bmcl.2018.01.038
	5	139	None	45	Human	Functional	pEC50	=	7.8	7.8	-33	26	Agonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2019.126703
	5202	139	None	45	Human	Functional	pEC50	=	7.8	7.8	-33	26	Agonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2019.126703
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.8	7.8	-33	26	Agonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2019.126703
	DB08839	139	None	45	Human	Functional	pEC50	=	7.8	7.8	-33	26	Agonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assayAgonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2019.126703
	25265257	17866	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	347	5	1	4	3.2	Cc1ccc(CNCC2(F)CCN(C(=O)c3cccs3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259032	17866	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	347	5	1	4	3.2	Cc1ccc(CNCC2(F)CCN(C(=O)c3cccs3)CC2)nc1	10.1021/jm100835q
	52948486	17927	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	417	5	2	4	3.5	Cc1ccc(CNCC2(O)CC3CCC(C2)N3C(=O)c2ccc(F)c(Cl)c2)nc1	10.1021/jm100835q
	CHEMBL1259200	17927	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	417	5	2	4	3.5	Cc1ccc(CNCC2(O)CC3CCC(C2)N3C(=O)c2ccc(F)c(Cl)c2)nc1	10.1021/jm100835q
	132257139	181218	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	426	7	1	3	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2F)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4760271	181218	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	426	7	1	3	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2F)CC1	10.1021/acs.jmedchem.0c00814
	57397588	71503	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	375	7	1	5	2.4	O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926747	71503	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	375	7	1	5	2.4	O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962460	71503	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	375	7	1	5	2.4	O=C1C2CCSN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	46180256	202686	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	289	2	0	2	3.5	C#CCOc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm9015763
	CHEMBL596885	202686	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	289	2	0	2	3.5	C#CCOc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm9015763
	24769156	116281	None	0	Human	Functional	pEC50	=	5.8	5.8	-6	2	Agonist activity at human 5HT1A receptor (unknown origin) expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1A receptor (unknown origin) expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	388	7	1	4	3.6	O=C(NCCCCN1CCN(c2ccccc2)CC1)c1ccc2ncccc2c1	10.1021/jm501119j
	CHEMBL3358509	116281	None	0	Human	Functional	pEC50	=	5.8	5.8	-6	2	Agonist activity at human 5HT1A receptor (unknown origin) expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1A receptor (unknown origin) expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	388	7	1	4	3.6	O=C(NCCCCN1CCN(c2ccccc2)CC1)c1ccc2ncccc2c1	10.1021/jm501119j
	44408784	166192	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	355	6	3	4	3.3	COc1ccc2c(c1)OC(CNCCc1c[nH]c3ccc(F)cc13)CN2	10.1016/j.bmcl.2005.11.054
	CHEMBL425936	166192	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	355	6	3	4	3.3	COc1ccc2c(c1)OC(CNCCc1c[nH]c3ccc(F)cc13)CN2	10.1016/j.bmcl.2005.11.054
	9799764	88375	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	375	5	2	3	4.4	Fc1ccc2[nH]cc(CCCNC3COc4ccc5ncccc5c4C3)c2c1	10.1016/j.bmcl.2007.03.049
	CHEMBL234853	88375	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	375	5	2	3	4.4	Fc1ccc2[nH]cc(CCCNC3COc4ccc5ncccc5c4C3)c2c1	10.1016/j.bmcl.2007.03.049
	187811	55090	None	7	Human	Functional	pEC50	=	5.7	5.7	-	1	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	216	5	2	1	3.0	CCCCc1ccc2[nH]cc(CCN)c2c1	nan
	CHEMBL1309229	55090	None	7	Human	Functional	pEC50	=	5.7	5.7	-	1	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	216	5	2	1	3.0	CCCCc1ccc2[nH]cc(CCN)c2c1	nan
	CHEMBL1616674	55090	None	7	Human	Functional	pEC50	=	5.7	5.7	-	1	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	216	5	2	1	3.0	CCCCc1ccc2[nH]cc(CCN)c2c1	nan
	23155625	18694	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting	ChEMBL	450	6	1	8	2.7	Nn1c(SCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2	10.1021/jm1002292
	CHEMBL1277281	18694	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting	ChEMBL	450	6	1	8	2.7	Nn1c(SCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2	10.1021/jm1002292
	CHEMBL5087922	217616	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc(N2CCN(CCCCc3c[nH]c4ccc(F)cc34)CC2)cc1	10.1016/j.ejmech.2021.114045
	138692456	182811	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	407	7	2	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCNc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4789505	182811	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	407	7	2	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCNc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL5080308	217166	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccoc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	11646498	102559	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	375	11	1	5	2.3	CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL2431051	102559	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	375	11	1	5	2.3	CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL3040382	102559	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	375	11	1	5	2.3	CCOc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	46225309	202596	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	454	8	2	4	4.3	N#Cc1ccc2[nH]cc(CCCCN(CC3CC3)C3COc4ccc5c(c4C3)C(=O)NC5)c2c1	10.1016/j.bmcl.2009.10.134
	CHEMBL596297	202596	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	454	8	2	4	4.3	N#Cc1ccc2[nH]cc(CCCCN(CC3CC3)C3COc4ccc5c(c4C3)C(=O)NC5)c2c1	10.1016/j.bmcl.2009.10.134
	5	139	None	45	Human	Functional	pEC50	=	7.7	7.7	-33	26	Agonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b01096
	5202	139	None	45	Human	Functional	pEC50	=	7.7	7.7	-33	26	Agonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b01096
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.7	7.7	-33	26	Agonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b01096
	DB08839	139	None	45	Human	Functional	pEC50	=	7.7	7.7	-33	26	Agonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.8b01096
	75	3514	None	10	Human	Functional	pEC50	=	7.7	7.7	-	1	Binding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-SBinding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-S	ChEMBL	497	3	1	4	5.9	CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1	10.1021/jm0341204
	9870500	3514	None	10	Human	Functional	pEC50	=	7.7	7.7	-	1	Binding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-SBinding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-S	ChEMBL	497	3	1	4	5.9	CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1	10.1021/jm0341204
	CHEMBL191971	3514	None	10	Human	Functional	pEC50	=	7.7	7.7	-	1	Binding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-SBinding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-S	ChEMBL	497	3	1	4	5.9	CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1	10.1021/jm0341204
	132256730	183421	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4797282	183421	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	56850926	71513	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	362	9	1	5	3.2	O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926759	71513	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	362	9	1	5	3.2	O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962491	71513	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	362	9	1	5	3.2	O=C1CSC(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	161665	172688	None	26	Human	Functional	pEC50	=	6.7	6.7	28	3	Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL448891	172688	None	26	Human	Functional	pEC50	=	6.7	6.7	28	3	Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	46176231	63986	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at 5-HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 minsAgonist activity at 5-HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins	ChEMBL	467	8	0	5	6.8	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)CCCCC2CCSS2)c1-3	10.1021/jm200347t
	CHEMBL1806874	63986	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at 5-HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 minsAgonist activity at 5-HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins	ChEMBL	467	8	0	5	6.8	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)CCCCC2CCSS2)c1-3	10.1021/jm200347t
	9844300	74704	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	407	4	1	4	4.3	COc1cccc2c1OC(CN1CC=C(c3c[nH]c4ccc(F)cc34)CC1)CN2C	10.1016/j.bmcl.2005.11.054
	CHEMBL203018	74704	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	407	4	1	4	4.3	COc1cccc2c1OC(CN1CC=C(c3c[nH]c4ccc(F)cc34)CC1)CN2C	10.1016/j.bmcl.2005.11.054
	44408681	141408	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	367	6	2	3	4.1	CC(C)N1CC(CNCCc2c[nH]c3ccc(F)cc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	CHEMBL383446	141408	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	367	6	2	3	4.1	CC(C)N1CC(CNCCc2c[nH]c3ccc(F)cc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	16109485	161839	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	353	9	1	3	5.3	CC(C)Oc1ccccc1OCCNCc1cccc(C2CCCC2)c1	10.1021/jm061180b
	CHEMBL413777	161839	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	353	9	1	3	5.3	CC(C)Oc1ccccc1OCCNCc1cccc(C2CCCC2)c1	10.1021/jm061180b
	44408702	140994	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	349	7	2	3	4.0	CCCN1CC(CNCCc2c[nH]c3ccccc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	CHEMBL382179	140994	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	349	7	2	3	4.0	CCCN1CC(CNCCc2c[nH]c3ccccc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	45102635	57141	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay	ChEMBL	311	4	1	3	3.8	Fc1cccc(Cl)c1Oc1cccc(F)c1OC1CNC1	10.1016/j.bmcl.2010.11.066
	CHEMBL1645600	57141	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay	ChEMBL	311	4	1	3	3.8	Fc1cccc(Cl)c1Oc1cccc(F)c1OC1CNC1	10.1016/j.bmcl.2010.11.066
	145	140	None	16	Human	Functional	pEC50	=	6.7	6.7	-27	12	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	nan
	1832	140	None	16	Human	Functional	pEC50	=	6.7	6.7	-27	12	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	nan
	CHEMBL7257	140	None	16	Human	Functional	pEC50	=	6.7	6.7	-27	12	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	nan
	DB14010	140	None	16	Human	Functional	pEC50	=	6.7	6.7	-27	12	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	nan
	156011035	177253	None	0	Human	Functional	pEC50	=	8.7	8.7	6	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	437	7	0	8	3.3	COc1cccc2nn(CCCCN3CCN(c4cccc5sccc45)CC3)c(=O)n12	10.1016/j.bmcl.2020.127027
	CHEMBL4634009	177253	None	0	Human	Functional	pEC50	=	8.7	8.7	6	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	437	7	0	8	3.3	COc1cccc2nn(CCCCN3CCN(c4cccc5sccc45)CC3)c(=O)n12	10.1016/j.bmcl.2020.127027
	11428089	18036	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	351	8	3	2	4.4	Fc1ccc2[nH]cc(CCCNCCOc3cccc4[nH]ccc34)c2c1	10.1021/jm0304010
	CHEMBL126424	18036	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	351	8	3	2	4.4	Fc1ccc2[nH]cc(CCCNCCOc3cccc4[nH]ccc34)c2c1	10.1021/jm0304010
	5	139	None	45	Human	Functional	pEC50	=	8.7	8.7	-33	26	Agonist activity at human 5-HT1A receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayAgonist activity at human 5-HT1A receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	5202	139	None	45	Human	Functional	pEC50	=	8.7	8.7	-33	26	Agonist activity at human 5-HT1A receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayAgonist activity at human 5-HT1A receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.7	8.7	-33	26	Agonist activity at human 5-HT1A receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayAgonist activity at human 5-HT1A receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	DB08839	139	None	45	Human	Functional	pEC50	=	8.7	8.7	-33	26	Agonist activity at human 5-HT1A receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayAgonist activity at human 5-HT1A receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2021.113243
	9802369	174089	None	17	Human	Functional	pEC50	=	8.7	8.7	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	422	6	2	4	4.0	CNc1nc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)ccc1C	10.1021/jm9806906
	CHEMBL45422	174089	None	17	Human	Functional	pEC50	=	8.7	8.7	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	422	6	2	4	4.0	CNc1nc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)ccc1C	10.1021/jm9806906
	156017961	177978	None	0	Human	Functional	pEC50	=	8.7	8.7	38	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	437	7	0	8	3.3	COc1cccn2c(=O)n(CCCCN3CCN(c4cccc5sccc45)CC3)nc12	10.1016/j.bmcl.2020.127027
	CHEMBL4644500	177978	None	0	Human	Functional	pEC50	=	8.7	8.7	38	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	437	7	0	8	3.3	COc1cccn2c(=O)n(CCCCN3CCN(c4cccc5sccc45)CC3)nc12	10.1016/j.bmcl.2020.127027
	145963961	164498	None	0	Human	Functional	pEC50	=	8.7	8.7	5	6	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	425	8	1	7	3.0	CNC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4213342	164498	None	0	Human	Functional	pEC50	=	8.7	8.7	5	6	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	425	8	1	7	3.0	CNC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	145981408	166594	None	0	Human	Functional	pEC50	=	8.6	8.6	2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	435	6	0	5	3.6	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3ccsc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4278581	166594	None	0	Human	Functional	pEC50	=	8.6	8.6	2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	435	6	0	5	3.6	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3ccsc23)CC1	10.1016/j.ejmech.2017.12.099
	49837354	18727	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting	ChEMBL	549	6	1	10	2.9	CC(=O)N1CCc2c(sc3nc(SCCCN4CCN(c5ccc6ccccc6n5)CC4)n(N)c(=O)c23)C1	10.1021/jm1002292
	CHEMBL1277558	18727	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting	ChEMBL	549	6	1	10	2.9	CC(=O)N1CCc2c(sc3nc(SCCCN4CCN(c5ccc6ccccc6n5)CC4)n(N)c(=O)c23)C1	10.1021/jm1002292
	10005161	207707	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Ability to influence the binding of [35S]GTP-gamma-S, to HeLa cell membranes expressing the human 5-hydroxytryptamine 1A receptorAbility to influence the binding of [35S]GTP-gamma-S, to HeLa cell membranes expressing the human 5-hydroxytryptamine 1A receptor	ChEMBL	475	9	1	8	3.3	CCC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2OC)CC1	10.1021/jm0009336
	CHEMBL78874	207707	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Ability to influence the binding of [35S]GTP-gamma-S, to HeLa cell membranes expressing the human 5-hydroxytryptamine 1A receptorAbility to influence the binding of [35S]GTP-gamma-S, to HeLa cell membranes expressing the human 5-hydroxytryptamine 1A receptor	ChEMBL	475	9	1	8	3.3	CCC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2OC)CC1	10.1021/jm0009336
	1220	187	None	44	Human	Functional	pEC50	=	8.6	8.6	-1	9	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm049493z
	31	187	None	44	Human	Functional	pEC50	=	8.6	8.6	-1	9	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm049493z
	7	187	None	44	Human	Functional	pEC50	=	8.6	8.6	-1	9	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm049493z
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	8.6	8.6	-1	9	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm049493z
	16109489	84412	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	362	7	1	4	4.3	C1=C(c2cncc(CNCCOc3cccc4c3OC3(CC3)C4)c2)CCC1	10.1021/jm061180b
	CHEMBL221920	84412	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	362	7	1	4	4.3	C1=C(c2cncc(CNCCOc3cccc4c3OC3(CC3)C4)c2)CCC1	10.1021/jm061180b
	10718870	168033	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	461	6	1	4	5.4	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3ccco3)n2)CC1	10.1021/jm9806906
	CHEMBL43146	168033	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	461	6	1	4	5.4	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3ccco3)n2)CC1	10.1021/jm9806906
	162651961	180284	None	0	Human	Functional	pEC50	=	8.6	8.6	7	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	448	7	0	7	4.2	COc1ccc2ncc(=O)n(CCCCN3CCN(c4cccc5sccc45)CC3)c2c1	10.1016/j.ejmech.2020.112572
	CHEMBL4749223	180284	None	0	Human	Functional	pEC50	=	8.6	8.6	7	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	448	7	0	7	4.2	COc1ccc2ncc(=O)n(CCCCN3CCN(c4cccc5sccc45)CC3)c2c1	10.1016/j.ejmech.2020.112572
	127049865	140304	None	0	Human	Functional	pEC50	=	8.6	8.6	4	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	442	8	1	6	3.8	CNC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
	CHEMBL3805099	140304	None	0	Human	Functional	pEC50	=	8.6	8.6	4	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	442	8	1	6	3.8	CNC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
	164609529	184570	None	0	Human	Functional	pEC50	=	8.6	8.6	36	2	Agonist activity at human 5-HT1A receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayAgonist activity at human 5-HT1A receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	CHEMBL4846823	184570	None	0	Human	Functional	pEC50	=	8.6	8.6	36	2	Agonist activity at human 5-HT1A receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayAgonist activity at human 5-HT1A receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assay	ChEMBL	383	5	0	4	4.1	CC1(CCCN2CCN(c3ccccn3)CC2)Cc2cc(Cl)ccc2C1=O	10.1016/j.ejmech.2021.113243
	10647622	166108	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	459	6	2	4	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1-c1cc[nH]n1	10.1021/jm9806906
	CHEMBL42545	166108	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	459	6	2	4	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1-c1cc[nH]n1	10.1021/jm9806906
	156013636	177351	None	0	Human	Functional	pEC50	=	8.6	8.6	41	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	408	6	0	8	2.7	O=c1n(CCCCN2CCN(c3cccc4scnc34)CC2)nc2ccccn12	10.1016/j.bmcl.2020.127027
	CHEMBL4635890	177351	None	0	Human	Functional	pEC50	=	8.6	8.6	41	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	408	6	0	8	2.7	O=c1n(CCCCN2CCN(c3cccc4scnc34)CC2)nc2ccccn12	10.1016/j.bmcl.2020.127027
	10474089	208140	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	366	6	0	5	3.2	O=C(CCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccccc1	10.1016/s0960-894x(98)00406-5
	CHEMBL542671	208140	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	366	6	0	5	3.2	O=C(CCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccccc1	10.1016/s0960-894x(98)00406-5
	CHEMBL82215	208140	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	366	6	0	5	3.2	O=C(CCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccccc1	10.1016/s0960-894x(98)00406-5
	10067360	141618	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	364	7	1	4	4.5	CC1(C)Cc2cccc(OCCNCc3cncc(C4=CCCC4)c3)c2O1	10.1021/jm061180b
	CHEMBL384657	141618	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	364	7	1	4	4.5	CC1(C)Cc2cccc(OCCNCc3cncc(C4=CCCC4)c3)c2O1	10.1021/jm061180b
	10474089	208140	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	366	6	0	5	3.2	O=C(CCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccccc1	10.1016/s0960-894x(98)00406-5
	CHEMBL542671	208140	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	366	6	0	5	3.2	O=C(CCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccccc1	10.1016/s0960-894x(98)00406-5
	CHEMBL82215	208140	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	366	6	0	5	3.2	O=C(CCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccccc1	10.1016/s0960-894x(98)00406-5
	9928432	18033	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	352	8	2	3	4.7	Fc1ccc2[nH]cc(CCCNCCOc3cccc4ccoc34)c2c1	10.1021/jm0304010
	CHEMBL126407	18033	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	352	8	2	3	4.7	Fc1ccc2[nH]cc(CCCNCCOc3cccc4ccoc34)c2c1	10.1021/jm0304010
	10248163	31571	None	0	Human	Functional	pEC50	=	8.5	8.5	-288	3	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	363	5	0	4	4.0	COc1cccc2c1CCC/C2=C\CCN1CCN(c2ccccn2)CC1	10.1016/j.bmc.2015.05.042
	CHEMBL140406	31571	None	0	Human	Functional	pEC50	=	8.5	8.5	-288	3	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	363	5	0	4	4.0	COc1cccc2c1CCC/C2=C\CCN1CCN(c2ccccn2)CC1	10.1016/j.bmc.2015.05.042
	10789182	178976	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	438	6	1	4	4.2	CN(C)c1cccc(CNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1021/jm9806906
	CHEMBL46971	178976	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	438	6	1	4	4.2	CN(C)c1cccc(CNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1021/jm9806906
	11430856	78050	None	28	Human	Functional	pEC50	=	7.7	7.7	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	450	10	2	5	3.0	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)c1	10.1021/jm0508641
	CHEMBL209821	78050	None	28	Human	Functional	pEC50	=	7.7	7.7	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	450	10	2	5	3.0	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)c1	10.1021/jm0508641
	10343434	78232	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	444	9	2	5	2.8	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)c3ccc(C)cc3)CC2)c1	10.1021/jm0508641
	CHEMBL210537	78232	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	444	9	2	5	2.8	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)c3ccc(C)cc3)CC2)c1	10.1021/jm0508641
	42605993	17887	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	425	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3sccc3Br)CC2)nc1	10.1021/jm100835q
	CHEMBL1259087	17887	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	425	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3sccc3Br)CC2)nc1	10.1021/jm100835q
	42606104	17895	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	361	5	1	4	3.5	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc(C)cs3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259107	17895	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	361	5	1	4	3.5	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc(C)cs3)CC2)nc1	10.1021/jm100835q
	156017859	177994	None	0	Human	Functional	pEC50	=	7.7	7.7	2	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	432	6	0	8	3.2	N#Cc1cccc2nn(CCCCN3CCN(c4cccc5sccc45)CC3)c(=O)n12	10.1016/j.bmcl.2020.127027
	CHEMBL4644742	177994	None	0	Human	Functional	pEC50	=	7.7	7.7	2	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	432	6	0	8	3.2	N#Cc1cccc2nn(CCCCN3CCN(c4cccc5sccc45)CC3)c(=O)n12	10.1016/j.bmcl.2020.127027
	132256796	182905	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	454	8	1	4	4.6	COc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4790662	182905	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	454	8	1	4	4.6	COc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	10550097	167575	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	420	6	1	4	4.1	CN(C)c1cccc(CNCC2CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1021/jm9806906
	CHEMBL42994	167575	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	420	6	1	4	4.1	CN(C)c1cccc(CNCC2CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1021/jm9806906
	10948133	165374	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	351	5	0	4	3.4	COc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)CC2	10.1016/j.bmc.2015.05.042
	CHEMBL423181	165374	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	351	5	0	4	3.4	COc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)CC2	10.1016/j.bmc.2015.05.042
	132257264	180626	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	410	7	1	5	2.9	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cnccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4753414	180626	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	410	7	1	5	2.9	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cnccn2)CC1	10.1021/acs.jmedchem.9b00062
	10835365	179024	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	409	5	1	3	4.4	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)nc1	10.1021/jm9806906
	CHEMBL47013	179024	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	409	5	1	3	4.4	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)nc1	10.1021/jm9806906
	44537925	201200	None	0	Human	Functional	pEC50	=	6.7	6.7	7	3	Agonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	CHEMBL582945	201200	None	0	Human	Functional	pEC50	=	6.7	6.7	7	3	Agonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	4806	4008	None	55	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS binding	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	71768094	4008	None	55	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS binding	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	71768094.0	4008	None	55	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS binding	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	7351	4008	None	55	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS binding	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	9966051	4008	None	55	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS binding	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	9966051.0	4008	None	55	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS binding	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	CHEMBL2104993	4008	None	55	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS binding	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	DB09068	4008	None	55	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as [35S]GTPgammaS binding	ChEMBL	298	3	1	3	3.9	Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1	10.1021/jm101459g
	CHEMBL5074796	216822	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6cccc(Cl)c6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	23625239	86038	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	409	6	2	4	3.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2ccc(CO)cn2)CC1	10.1021/jm070714l
	CHEMBL230425	86038	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	409	6	2	4	3.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2ccc(CO)cn2)CC1	10.1021/jm070714l
	130431319	172623	None	0	Human	Functional	pEC50	=	5.7	5.7	-11	2	Agonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	454	8	3	4	3.7	CCc1cccc(N2CCN(C[C@@H](O)CCNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl	10.1021/acs.jmedchem.9b00607
	CHEMBL4483569	172623	None	0	Human	Functional	pEC50	=	5.7	5.7	-11	2	Agonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	454	8	3	4	3.7	CCc1cccc(N2CCN(C[C@@H](O)CCNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl	10.1021/acs.jmedchem.9b00607
	398712	77898	None	2	Human	Functional	pEC50	=	7.7	7.7	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
	CHEMBL209324	77898	None	2	Human	Functional	pEC50	=	7.7	7.7	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
	168290985	193010	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at 5-HT1A receptor (unknown origin) transfected in HEK293 cells by calcium flux assayAgonist activity at 5-HT1A receptor (unknown origin) transfected in HEK293 cells by calcium flux assay	ChEMBL	235	5	1	2	2.6	NC[C@H]1C[C@@H]1c1cc(F)ccc1COC1CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5199680	193010	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at 5-HT1A receptor (unknown origin) transfected in HEK293 cells by calcium flux assayAgonist activity at 5-HT1A receptor (unknown origin) transfected in HEK293 cells by calcium flux assay	ChEMBL	235	5	1	2	2.6	NC[C@H]1C[C@@H]1c1cc(F)ccc1COC1CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5222077	193010	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at 5-HT1A receptor (unknown origin) transfected in HEK293 cells by calcium flux assayAgonist activity at 5-HT1A receptor (unknown origin) transfected in HEK293 cells by calcium flux assay	ChEMBL	235	5	1	2	2.6	NC[C@H]1C[C@@H]1c1cc(F)ccc1COC1CC1	10.1021/acs.jmedchem.2c00633
	91242334	167468	None	1	Human	Functional	pEC50	=	7.7	7.7	6	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	419	6	0	5	4.1	O=C1c2ccccc2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4294797	167468	None	1	Human	Functional	pEC50	=	7.7	7.7	6	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	419	6	0	5	4.1	O=C1c2ccccc2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	11395034	71523	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	385	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926751	71523	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	385	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962585	71523	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	385	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	1220	187	None	44	Human	Functional	pEC50	=	7.7	7.7	-1	9	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/acs.jmedchem.0c00814
	31	187	None	44	Human	Functional	pEC50	=	7.7	7.7	-1	9	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/acs.jmedchem.0c00814
	7	187	None	44	Human	Functional	pEC50	=	7.7	7.7	-1	9	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/acs.jmedchem.0c00814
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	7.7	7.7	-1	9	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/acs.jmedchem.0c00814
	132247312	180761	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	465	8	2	4	4.1	CC(=O)Nc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4755058	180761	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	465	8	2	4	4.1	CC(=O)Nc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	10787547	172702	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	406	6	2	4	4.1	CNc1cccc(CNCC2CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1021/jm9806906
	CHEMBL44904	172702	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	406	6	2	4	4.1	CNc1cccc(CNCC2CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1021/jm9806906
	CHEMBL5090651	217766	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc(N2CCN(CCCCc3c[nH]c4ccc(Cl)cc34)CC2)cc1	10.1016/j.ejmech.2021.114045
	53248213	62054	None	0	Human	Functional	pEC50	=	5.7	5.7	-2	2	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	462	7	2	3	4.8	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm200288r
	CHEMBL1774535	62054	None	0	Human	Functional	pEC50	=	5.7	5.7	-2	2	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	462	7	2	3	4.8	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm200288r
	44591261	180936	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	379	6	2	4	4.1	Fc1cccc2c(CCN3CCCC(c4ccnc(NC5CC5)n4)C3)c[nH]c12	10.1016/j.bmcl.2008.12.087
	CHEMBL475694	180936	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	379	6	2	4	4.1	Fc1cccc2c(CCN3CCCC(c4ccnc(NC5CC5)n4)C3)c[nH]c12	10.1016/j.bmcl.2008.12.087
	45375937	201302	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay	ChEMBL	271	3	1	2	4.1	Fc1cccc(Oc2ccccc2C2CCNCC2)c1	10.1016/j.bmcl.2009.10.014
	CHEMBL583752	201302	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay	ChEMBL	271	3	1	2	4.1	Fc1cccc(Oc2ccccc2C2CCNCC2)c1	10.1016/j.bmcl.2009.10.014
	CHEMBL5088919	217676	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6cccnc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	46225264	204252	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	386	5	3	4	2.8	N#Cc1ccc2[nH]cc(CCCNC3COc4ccc5c(c4C3)C(=O)NC5)c2c1	10.1016/j.bmcl.2009.10.134
	CHEMBL606864	204252	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	386	5	3	4	2.8	N#Cc1ccc2[nH]cc(CCCNC3COc4ccc5c(c4C3)C(=O)NC5)c2c1	10.1016/j.bmcl.2009.10.134
	417608	119227	None	24	Human	Functional	pEC50	=	7.7	7.7	-	1	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	246	6	1	2	3.1	CCN(CC)CCc1c[nH]c2ccc(OC)cc12	10.1021/jm000339w
	CHEMBL342986	119227	None	24	Human	Functional	pEC50	=	7.7	7.7	-	1	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	246	6	1	2	3.1	CCN(CC)CCc1c[nH]c2ccc(OC)cc12	10.1021/jm000339w
	CHEMBL5080984	217201	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6cc[nH]c6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	11430418	18793	None	9	Human	Functional	pEC50	=	7.7	7.7	177	3	Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting	ChEMBL	432	6	1	7	2.5	Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2	10.1021/jm1002292
	CHEMBL1278088	18793	None	9	Human	Functional	pEC50	=	7.7	7.7	177	3	Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting	ChEMBL	432	6	1	7	2.5	Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2	10.1021/jm1002292
	CHEMBL5087351	217577	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		COC(=O)c1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccccc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	162677377	183646	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	366	7	0	4	3.1	CC(C)N(CCCN1CCN(c2ccccn2)CC1)C(=O)c1ccccc1	10.1016/j.ejmech.2020.112214
	CHEMBL4800109	183646	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	366	7	0	4	3.1	CC(C)N(CCCN1CCN(c2ccccn2)CC1)C(=O)c1ccccc1	10.1016/j.ejmech.2020.112214
	10743303	178440	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	478	6	1	5	5.2	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3nccs3)n2)CC1	10.1021/jm9806906
	CHEMBL46512	178440	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	478	6	1	5	5.2	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3nccs3)n2)CC1	10.1021/jm9806906
	10427186	208378	None	0	Rat	Functional	pEC50	=	6.7	6.7	-57	2	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	337	5	3	5	3.5	O=[N+]([O-])c1cccnc1Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm00042a003
	CHEMBL84107	208378	None	0	Rat	Functional	pEC50	=	6.7	6.7	-57	2	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	337	5	3	5	3.5	O=[N+]([O-])c1cccnc1Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1	10.1021/jm00042a003
	146	135	None	50	Human	Functional	pEC50	=	5.7	5.7	-851	2	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	nan
	164682	135	None	50	Human	Functional	pEC50	=	5.7	5.7	-851	2	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	nan
	CHEMBL275628	135	None	50	Human	Functional	pEC50	=	5.7	5.7	-851	2	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	nan
	168295509	192623	None	0	Human	Functional	pEC50	=	4.7	4.7	-	1	Agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assayAgonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assay	ChEMBL	449	6	1	8	3.0	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5O)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5209283	192623	None	0	Human	Functional	pEC50	=	4.7	4.7	-	1	Agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assayAgonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assay	ChEMBL	449	6	1	8	3.0	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5O)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	51003382	57142	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay	ChEMBL	291	4	1	3	3.4	Cc1cccc(F)c1Oc1cccc(F)c1OC1CNC1	10.1016/j.bmcl.2010.11.066
	CHEMBL1645601	57142	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay	ChEMBL	291	4	1	3	3.4	Cc1cccc(F)c1Oc1cccc(F)c1OC1CNC1	10.1016/j.bmcl.2010.11.066
	5	139	None	45	Human	Functional	pEC50	=	6.6	6.6	-33	26	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm070714l
	5202	139	None	45	Human	Functional	pEC50	=	6.6	6.6	-33	26	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm070714l
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	6.6	6.6	-33	26	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm070714l
	DB08839	139	None	45	Human	Functional	pEC50	=	6.6	6.6	-33	26	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm070714l
	10364325	149447	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	411	6	1	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2ccc(CF)cn2)CC1	10.1021/jm070714l
	CHEMBL394530	149447	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	411	6	1	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2ccc(CF)cn2)CC1	10.1021/jm070714l
	11595672	102647	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	361	10	1	5	1.9	COc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL2431048	102647	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	361	10	1	5	1.9	COc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	CHEMBL3040882	102647	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	361	10	1	5	1.9	COc1ccccc1OCCNCCCCN1C(=O)C2CCCN2C1=O	10.1021/jm400766k
	11573726	71555	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	343	6	1	4	1.8	O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926750	71555	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	343	6	1	4	1.8	O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962912	71555	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	343	6	1	4	1.8	O=C1C2CCCN2C(=O)N1CCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	9865384	173599	None	32	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	393	5	1	3	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm070714l
	9865384.0	173599	None	32	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	393	5	1	3	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm070714l
	CHEMBL45305	173599	None	32	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	393	5	1	3	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm070714l
	145975214	164013	None	0	Human	Functional	pEC50	=	7.6	7.6	2	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	436	8	1	5	3.7	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.bmcl.2018.01.038
	CHEMBL4207328	164013	None	0	Human	Functional	pEC50	=	7.6	7.6	2	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	436	8	1	5	3.7	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)n1	10.1016/j.bmcl.2018.01.038
	23626001	86012	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	429	6	1	3	4.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2ccc(C(F)F)cn2)CC1	10.1021/jm070714l
	CHEMBL230327	86012	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	429	6	1	3	4.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2ccc(C(F)F)cn2)CC1	10.1021/jm070714l
	46225207	204358	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	433	7	2	3	4.2	O=C1NCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)CC1CC1)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL607419	204358	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	433	7	2	3	4.2	O=C1NCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)CC1CC1)CO3	10.1016/j.bmcl.2009.10.134
	242	470	None	70	Human	Functional	pEC50	=	7.6	7.6	-31	33	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	34	470	None	70	Human	Functional	pEC50	=	7.6	7.6	-31	33	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	60795	470	None	70	Human	Functional	pEC50	=	7.6	7.6	-31	33	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	60795.0	470	None	70	Human	Functional	pEC50	=	7.6	7.6	-31	33	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	CHEMBL1112	470	None	70	Human	Functional	pEC50	=	7.6	7.6	-31	33	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	DB01238	470	None	70	Human	Functional	pEC50	=	7.6	7.6	-31	33	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	127050765	140301	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	435	8	1	4	4.3	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805077	140301	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	435	8	1	4	4.3	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	129186528	157557	None	0	Human	Functional	pEC50	=	7.6	7.6	-4	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	442	4	0	6	4.2	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2Cl	10.1016/j.bmc.2017.07.040
	CHEMBL4079251	157557	None	0	Human	Functional	pEC50	=	7.6	7.6	-4	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	442	4	0	6	4.2	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2Cl	10.1016/j.bmc.2017.07.040
	16109487	83429	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	365	7	1	4	4.9	CC1(C)Oc2cccc(OCCNCc3cccc(C4=CCCC4)c3)c2O1	10.1021/jm061180b
	CHEMBL219486	83429	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	365	7	1	4	4.9	CC1(C)Oc2cccc(OCCNCc3cccc(C4=CCCC4)c3)c2O1	10.1021/jm061180b
	162666972	182646	None	0	Human	Functional	pEC50	=	7.6	7.6	309	2	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	378	8	0	4	3.1	O=C(c1ccccc1)N(CCCN1CCN(c2ccccn2)CC1)CC1CC1	10.1016/j.ejmech.2020.112214
	CHEMBL4787394	182646	None	0	Human	Functional	pEC50	=	7.6	7.6	309	2	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	378	8	0	4	3.1	O=C(c1ccccc1)N(CCCN1CCN(c2ccccn2)CC1)CC1CC1	10.1016/j.ejmech.2020.112214
	42606461	17875	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	331	5	1	4	2.7	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccoc3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259051	17875	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	331	5	1	4	2.7	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccoc3)CC2)nc1	10.1021/jm100835q
	42606337	17939	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	397	5	1	4	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc4ccccc4s3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259242	17939	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	397	5	1	4	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc4ccccc4s3)CC2)nc1	10.1021/jm100835q
	11741361	2830	None	36	Human	Functional	pEC50	=	6.6	6.6	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/acs.jmedchem.9b00062
	3924	2830	None	36	Human	Functional	pEC50	=	6.6	6.6	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/acs.jmedchem.9b00062
	CHEMBL230963	2830	None	36	Human	Functional	pEC50	=	6.6	6.6	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/acs.jmedchem.9b00062
	146025790	183102	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	424	7	1	3	4.8	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCSc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4793515	183102	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	424	7	1	3	4.8	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCSc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL5087427	217587	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		CCCCN1CCC(CCC(=O)c2ccc(N3CCN(CCCCc4c[nH]c5ccc(C#N)cc45)CC3)cc2)CC1	10.1016/j.ejmech.2021.114045
	46227754	204124	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	393	5	3	3	3.1	O=C1NCCc2ccc3c(c21)CC(NCCCc1c[nH]c2ccc(F)cc12)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL606149	204124	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	393	5	3	3	3.1	O=C1NCCc2ccc3c(c21)CC(NCCCc1c[nH]c2ccc(F)cc12)CO3	10.1016/j.bmcl.2009.10.134
	132256811	180049	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2Cl)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4746386	180049	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2Cl)CC1	10.1021/acs.jmedchem.0c00814
	9865384	173599	None	32	Human	Functional	pEC50	=	7.6	7.6	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	393	5	1	3	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm9806906
	9865384.0	173599	None	32	Human	Functional	pEC50	=	7.6	7.6	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	393	5	1	3	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm9806906
	CHEMBL45305	173599	None	32	Human	Functional	pEC50	=	7.6	7.6	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	393	5	1	3	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm9806906
	11175450	117011	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	347	9	3	2	4.6	c1ccc2c(CCCCNCCOc3cccc4[nH]ccc34)c[nH]c2c1	10.1021/jm0304010
	CHEMBL338587	117011	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	347	9	3	2	4.6	c1ccc2c(CCCCNCCOc3cccc4[nH]ccc34)c[nH]c2c1	10.1021/jm0304010
	11603514	71514	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	390	11	1	5	4.0	O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926760	71514	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	390	11	1	5	4.0	O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962492	71514	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	390	11	1	5	4.0	O=C1CSC(=O)N1CCCCCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	122183771	122306	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	3	Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	426	7	2	3	4.7	O=C(NCCCCN1CCN(c2cccc3ccccc23)CC1)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.5b00776
	CHEMBL3597643	122306	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	3	Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	426	7	2	3	4.7	O=C(NCCCCN1CCN(c2cccc3ccccc23)CC1)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.5b00776
	132256730	183421	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4797282	183421	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	44461160	105484	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	429	4	0	7	1.4	O=C1c2ccccc2S(=O)(=O)N1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	CHEMBL311976	105484	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	429	4	0	7	1.4	O=C1c2ccccc2S(=O)(=O)N1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	168295269	192621	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assayAgonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assay	ChEMBL	463	7	0	8	3.3	COc1cccc(N2CCN(CC3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)CC2)c1	10.1016/j.ejmech.2022.114218
	CHEMBL5209272	192621	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assayAgonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assay	ChEMBL	463	7	0	8	3.3	COc1cccc(N2CCN(CC3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)CC2)c1	10.1016/j.ejmech.2022.114218
	15980810	202114	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	435	6	2	3	4.2	CC(C)N(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NCC3	10.1016/j.bmcl.2009.10.134
	CHEMBL592951	202114	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	435	6	2	3	4.2	CC(C)N(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NCC3	10.1016/j.bmcl.2009.10.134
	1220	187	None	44	Human	Functional	pEC50	=	7.6	7.6	-1	9	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm8007097
	31	187	None	44	Human	Functional	pEC50	=	7.6	7.6	-1	9	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm8007097
	7	187	None	44	Human	Functional	pEC50	=	7.6	7.6	-1	9	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm8007097
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	7.6	7.6	-1	9	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm8007097
	CHEMBL5085893	217486	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6cccnc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	CHEMBL5094829	218005	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6cc[nH]c6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	46227757	203748	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	407	5	2	3	3.5	CN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NCC3	10.1016/j.bmcl.2009.10.134
	CHEMBL604063	203748	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	407	5	2	3	3.5	CN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NCC3	10.1016/j.bmcl.2009.10.134
	127049517	140290	None	0	Human	Functional	pEC50	=	7.6	7.6	-2	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	465	9	1	5	4.3	CNC(=O)c1ccc(OC)c(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3804943	140290	None	0	Human	Functional	pEC50	=	7.6	7.6	-2	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	465	9	1	5	4.3	CNC(=O)c1ccc(OC)c(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	127051038	140399	None	0	Human	Functional	pEC50	=	7.6	7.6	2	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	421	8	1	4	4.1	NC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3806169	140399	None	0	Human	Functional	pEC50	=	7.6	7.6	2	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	421	8	1	4	4.1	NC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	9950538	207316	None	0	Human	Functional	pEC50	=	7.6	7.6	-630	4	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pigCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pig	ChEMBL	355	3	1	4	4.0	CN1CCC[C@@H]1Cc1c[nH]c2ccc(-n3cnc4cc(C#N)ccc43)cc12	10.1016/0960-894X(95)00417-R
	CHEMBL75642	207316	None	0	Human	Functional	pEC50	=	7.6	7.6	-630	4	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pigCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pig	ChEMBL	355	3	1	4	4.0	CN1CCC[C@@H]1Cc1c[nH]c2ccc(-n3cnc4cc(C#N)ccc43)cc12	10.1016/0960-894X(95)00417-R
	49782156	17930	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	387	5	1	3	4.2	Cc1ccc(CNCC2(F)CCN(C(=O)C34CCCC(CCC3)C4)CC2)nc1	10.1021/jm100835q
	CHEMBL1259210	17930	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	387	5	1	3	4.2	Cc1ccc(CNCC2(F)CCN(C(=O)C34CCCC(CCC3)C4)CC2)nc1	10.1021/jm100835q
	137658832	159433	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	448	4	1	8	2.1	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4c3OC(F)(F)O4)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	CHEMBL4100152	159433	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	448	4	1	8	2.1	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4c3OC(F)(F)O4)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	10503335	167958	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	441	6	1	5	4.1	O=C(c1ccc(Cl)c(Cl)c1)N1CC=C(CNCc2cccc(-n3cccn3)n2)CC1	10.1021/jm9806906
	CHEMBL43097	167958	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	441	6	1	5	4.1	O=C(c1ccc(Cl)c(Cl)c1)N1CC=C(CNCc2cccc(-n3cccn3)n2)CC1	10.1021/jm9806906
	5	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2015.05.042
	5202	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2015.05.042
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2015.05.042
	DB08839	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISAAgonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by ELISA	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2015.05.042
	155533824	172001	None	0	Human	Functional	pEC50	=	7.6	7.6	25	2	Agonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	238	2	0	2	2.7	CCc1cccc(N2CCN(C)CC2)c1Cl	10.1021/acs.jmedchem.6b00860
	CHEMBL4469777	172001	None	0	Human	Functional	pEC50	=	7.6	7.6	25	2	Agonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	238	2	0	2	2.7	CCc1cccc(N2CCN(C)CC2)c1Cl	10.1021/acs.jmedchem.6b00860
	49781265	103463	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	365	5	2	4	2.7	Cc1ccc(CNC[C@]2(O)C[C@@H]3CC[C@H](C2)N3C(=O)c2ccccc2)nc1	10.1021/jm100835q
	CHEMBL3084757	103463	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	365	5	2	4	2.7	Cc1ccc(CNC[C@]2(O)C[C@@H]3CC[C@H](C2)N3C(=O)c2ccccc2)nc1	10.1021/jm100835q
	132247309	179546	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	476	7	1	3	5.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(C(F)(F)F)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4740430	179546	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	476	7	1	3	5.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(C(F)(F)F)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL5088060	217625	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccccc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	46225166	201974	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	407	6	2	3	3.8	CCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NC3	10.1016/j.bmcl.2009.10.134
	CHEMBL592029	201974	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	407	6	2	3	3.8	CCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NC3	10.1016/j.bmcl.2009.10.134
	145964622	164441	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	452	9	1	6	4.3	O=C(NC1CC1)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4212622	164441	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	452	9	1	6	4.3	O=C(NC1CC1)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	172449599	195693	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	407	8	2	5	2.9	COc1cccc(N2CCN(CCCCNC(=O)c3n[nH]c4ccccc34)CC2)c1	10.1016/j.ejmech.2023.115285
	CHEMBL5409227	195693	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	407	8	2	5	2.9	COc1cccc(N2CCN(CCCCNC(=O)c3n[nH]c4ccccc34)CC2)c1	10.1016/j.ejmech.2023.115285
	1220	187	None	44	Human	Functional	pEC50	=	7.6	7.6	-1	9	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm061180b
	31	187	None	44	Human	Functional	pEC50	=	7.6	7.6	-1	9	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm061180b
	7	187	None	44	Human	Functional	pEC50	=	7.6	7.6	-1	9	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm061180b
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	7.6	7.6	-1	9	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm061180b
	10742699	169318	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	461	6	1	5	4.3	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(-n3cccn3)n2)CC1	10.1021/jm9806906
	CHEMBL440854	169318	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	461	6	1	5	4.3	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(-n3cccn3)n2)CC1	10.1021/jm9806906
	CHEMBL5082360	217290	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		COc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccccc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	118626089	165568	None	3	Human	Functional	pEC50	=	7.6	7.6	-	1	Partial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assayPartial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assay	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	CHEMBL4239823	165568	None	3	Human	Functional	pEC50	=	7.6	7.6	-	1	Partial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assayPartial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assay	ChEMBL	506	6	0	6	4.8	O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2018.01.002
	172449599	195693	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	407	8	2	5	2.9	COc1cccc(N2CCN(CCCCNC(=O)c3n[nH]c4ccccc34)CC2)c1	10.1016/j.ejmech.2023.115285
	CHEMBL5409227	195693	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 minsAgonist activity at human 5HT1A expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production preincubated for 10 mins followed by forskolin addition for 5 mins	ChEMBL	407	8	2	5	2.9	COc1cccc(N2CCN(CCCCNC(=O)c3n[nH]c4ccccc34)CC2)c1	10.1016/j.ejmech.2023.115285
	137643395	158239	None	0	Human	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	426	4	1	7	2.4	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4c3CCS4)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	CHEMBL4087246	158239	None	0	Human	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	426	4	1	7	2.4	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4c3CCS4)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	145961788	161665	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	478	6	2	5	5.2	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(N)c6c(nc5c4)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	CHEMBL4129051	161665	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	478	6	2	5	5.2	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(N)c6c(nc5c4)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	132257264	180626	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	410	7	1	5	2.9	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cnccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4753414	180626	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	410	7	1	5	2.9	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cnccn2)CC1	10.1021/acs.jmedchem.9b00062
	10695466	172817	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	464	8	1	4	4.8	CCN(CC)c1nc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)ccc1C	10.1021/jm9806906
	CHEMBL45048	172817	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	464	8	1	4	4.8	CCN(CC)c1nc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)ccc1C	10.1021/jm9806906
	46225310	202507	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	393	6	3	3	3.5	O=C1NCc2ccc3c(c21)CC(NCCCCc1c[nH]c2ccc(F)cc12)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL595622	202507	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	393	6	3	3	3.5	O=C1NCc2ccc3c(c21)CC(NCCCCc1c[nH]c2ccc(F)cc12)CO3	10.1016/j.bmcl.2009.10.134
	242	470	None	70	Human	Functional	pEC50	=	6.5	6.5	-31	33	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2016.04.087
	34	470	None	70	Human	Functional	pEC50	=	6.5	6.5	-31	33	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2016.04.087
	60795	470	None	70	Human	Functional	pEC50	=	6.5	6.5	-31	33	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2016.04.087
	60795.0	470	None	70	Human	Functional	pEC50	=	6.5	6.5	-31	33	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2016.04.087
	CHEMBL1112	470	None	70	Human	Functional	pEC50	=	6.5	6.5	-31	33	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2016.04.087
	DB01238	470	None	70	Human	Functional	pEC50	=	6.5	6.5	-31	33	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2016.04.087
	55191	99671	None	43	Human	Functional	pEC50	=	6.5	6.5	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	359	6	0	6	1.6	CC1(C)CC(=O)N(CCCCN2CCN(c3ncccn3)CC2)C(=O)C1	10.1021/jm0508641
	55191.0	99671	None	43	Human	Functional	pEC50	=	6.5	6.5	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	359	6	0	6	1.6	CC1(C)CC(=O)N(CCCCN2CCN(c3ncccn3)CC2)C(=O)C1	10.1021/jm0508641
	CHEMBL284092	99671	None	43	Human	Functional	pEC50	=	6.5	6.5	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	359	6	0	6	1.6	CC1(C)CC(=O)N(CCCCN2CCN(c3ncccn3)CC2)C(=O)C1	10.1021/jm0508641
	DB12184	99671	None	43	Human	Functional	pEC50	=	6.5	6.5	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	359	6	0	6	1.6	CC1(C)CC(=O)N(CCCCN2CCN(c3ncccn3)CC2)C(=O)C1	10.1021/jm0508641
	135399666	168866	None	4	Human	Functional	pEC50	=	5.5	5.5	-33	6	Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP productionAgonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP production	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL437314	168866	None	4	Human	Functional	pEC50	=	5.5	5.5	-33	6	Agonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP productionAgonistic activity at cloned human 5HT1A receptor expressed in CHO cells by inhibition of forskolin-induced cAMP production	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL5084736	217421	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		C#CCN1CCC(CCC(=O)c2ccc(N3CCN(CCCCc4c[nH]c5ccc(C#N)cc45)CC3)cc2)CC1	10.1016/j.ejmech.2021.114045
	CHEMBL5092455	217859	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccoc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	132247303	180365	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	451	8	2	4	3.2	NC(=O)c1ccccc1OCCNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4750444	180365	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	451	8	2	4	3.2	NC(=O)c1ccccc1OCCNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	44591281	180399	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	362	6	1	4	4.0	c1ccc2c(c1)CC(CCN1CCCC(c3ccnc(NC4CC4)n3)C1)C2	10.1016/j.bmcl.2008.12.087
	CHEMBL475090	180399	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	362	6	1	4	4.0	c1ccc2c(c1)CC(CCN1CCCC(c3ccnc(NC4CC4)n3)C1)C2	10.1016/j.bmcl.2008.12.087
	5	139	None	45	Human	Functional	pEC50	=	8.5	8.5	-33	26	Agonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2014.09.024
	5202	139	None	45	Human	Functional	pEC50	=	8.5	8.5	-33	26	Agonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2014.09.024
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.5	8.5	-33	26	Agonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2014.09.024
	DB08839	139	None	45	Human	Functional	pEC50	=	8.5	8.5	-33	26	Agonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2014.09.024
	9906183	118167	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	345	8	2	3	4.3	c1cnc2c(OCCNCCCc3c[nH]c4ccccc34)cccc2c1	10.1021/jm0304010
	CHEMBL340705	118167	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	345	8	2	3	4.3	c1cnc2c(OCCNCCCc3c[nH]c4ccccc34)cccc2c1	10.1021/jm0304010
	10789419	172859	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	443	6	2	4	4.4	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(-c3cc[nH]n3)n2)CC1	10.1021/jm9806906
	CHEMBL45101	172859	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	443	6	2	4	4.4	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(-c3cc[nH]n3)n2)CC1	10.1021/jm9806906
	145988006	167217	None	0	Human	Functional	pEC50	=	8.5	8.5	14	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	553	8	0	9	2.9	CC(=O)O[C@H]1[C@H]2C[C@H]([C@@H]3C(=O)N(CCCCN4CCN(c5cccc6sccc56)CC4)C(=O)[C@H]23)[C@H]1OC(C)=O	10.1016/j.ejmech.2017.12.099
	CHEMBL4290309	167217	None	0	Human	Functional	pEC50	=	8.5	8.5	14	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	553	8	0	9	2.9	CC(=O)O[C@H]1[C@H]2C[C@H]([C@@H]3C(=O)N(CCCCN4CCN(c5cccc6sccc56)CC4)C(=O)[C@H]23)[C@H]1OC(C)=O	10.1016/j.ejmech.2017.12.099
	145990482	167079	None	0	Human	Functional	pEC50	=	8.5	8.5	2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	436	6	0	6	3.0	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3scnc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4287752	167079	None	0	Human	Functional	pEC50	=	8.5	8.5	2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	436	6	0	6	3.0	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3scnc23)CC1	10.1016/j.ejmech.2017.12.099
	1220	187	None	44	Human	Functional	pEC50	=	8.5	8.5	-1	9	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2021.114045
	31	187	None	44	Human	Functional	pEC50	=	8.5	8.5	-1	9	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2021.114045
	7	187	None	44	Human	Functional	pEC50	=	8.5	8.5	-1	9	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2021.114045
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	8.5	8.5	-1	9	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.ejmech.2021.114045
	162643405	181857	None	0	Human	Functional	pEC50	=	8.5	8.5	8	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	434	6	1	6	3.5	O=c1[nH]c(=O)n(CCCCN2CCN(c3cccc4sccc34)CC2)c2ccccc12	10.1016/j.ejmech.2020.112572
	CHEMBL4777475	181857	None	0	Human	Functional	pEC50	=	8.5	8.5	8	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	434	6	1	6	3.5	O=c1[nH]c(=O)n(CCCCN2CCN(c3cccc4sccc34)CC2)c2ccccc12	10.1016/j.ejmech.2020.112572
	5	139	None	45	Human	Functional	pEC50	=	8.5	8.5	-33	26	Agonist activity at 5-HT1A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT1A receptor (unknown origin) by calcium flux assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.3c00734
	5202	139	None	45	Human	Functional	pEC50	=	8.5	8.5	-33	26	Agonist activity at 5-HT1A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT1A receptor (unknown origin) by calcium flux assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.3c00734
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.5	8.5	-33	26	Agonist activity at 5-HT1A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT1A receptor (unknown origin) by calcium flux assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.3c00734
	DB08839	139	None	45	Human	Functional	pEC50	=	8.5	8.5	-33	26	Agonist activity at 5-HT1A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT1A receptor (unknown origin) by calcium flux assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.3c00734
	10647006	165548	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	445	6	1	4	4.9	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3ccco3)n2)CC1	10.1021/jm9806906
	CHEMBL42393	165548	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	445	6	1	4	4.9	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3ccco3)n2)CC1	10.1021/jm9806906
	132257058	181015	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	449	7	2	4	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3c2CCN3)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4757755	181015	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	449	7	2	4	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3c2CCN3)CC1	10.1021/acs.jmedchem.0c00814
	11518341	77076	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	464	10	1	5	3.4	CC(=O)Nc1cccc(N2CCN(CCCCN(C)S(=O)(=O)CC3CCCCC3)CC2)c1	10.1021/jm0508641
	CHEMBL207220	77076	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	464	10	1	5	3.4	CC(=O)Nc1cccc(N2CCN(CCCCN(C)S(=O)(=O)CC3CCCCC3)CC2)c1	10.1021/jm0508641
	145983928	166507	None	0	Human	Functional	pEC50	=	8.4	8.4	1	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	435	6	0	5	3.6	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4277101	166507	None	0	Human	Functional	pEC50	=	8.4	8.4	1	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	435	6	0	5	3.6	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	145992860	166968	None	0	Human	Functional	pEC50	=	8.4	8.4	2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	437	6	0	6	2.2	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4285839	166968	None	0	Human	Functional	pEC50	=	8.4	8.4	2	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	437	6	0	6	2.2	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/j.ejmech.2017.12.099
	10740939	122688	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	422	6	1	4	3.7	CN(C)c1cccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)n1	10.1021/jm9806906
	CHEMBL360319	122688	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	422	6	1	4	3.7	CN(C)c1cccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)n1	10.1021/jm9806906
	10694239	173716	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	436	6	1	4	4.0	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1N(C)C	10.1021/jm9806906
	CHEMBL45336	173716	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	436	6	1	4	4.0	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1N(C)C	10.1021/jm9806906
	5	139	None	45	Human	Functional	pEC50	=	8.4	8.4	-33	26	Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2012.12.016
	5202	139	None	45	Human	Functional	pEC50	=	8.4	8.4	-33	26	Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2012.12.016
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.4	8.4	-33	26	Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2012.12.016
	DB08839	139	None	45	Human	Functional	pEC50	=	8.4	8.4	-33	26	Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2012.12.016
	42606101	17882	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	425	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(Br)s3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259072	17882	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	425	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(Br)s3)CC2)nc1	10.1021/jm100835q
	42605991	17907	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	381	5	1	4	3.8	Cc1ccc(CNCC2(F)CCN(C(=O)c3sccc3Cl)CC2)nc1	10.1021/jm100835q
	CHEMBL1259139	17907	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	381	5	1	4	3.8	Cc1ccc(CNCC2(F)CCN(C(=O)c3sccc3Cl)CC2)nc1	10.1021/jm100835q
	11464531	18738	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting	ChEMBL	428	6	1	7	2.8	Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2ccccc2c1=O	10.1021/jm1002292
	CHEMBL1277651	18738	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation countingAgonist activity at human cloned 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 mins by liquid scintillation counting	ChEMBL	428	6	1	7	2.8	Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2ccccc2c1=O	10.1021/jm1002292
	137631570	156575	None	0	Human	Functional	pEC50	=	7.5	7.5	5	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	430	4	1	8	3.0	Cc1nc2n(c(=O)c1CCN1CCN(c3csc4ccsc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	CHEMBL4067506	156575	None	0	Human	Functional	pEC50	=	7.5	7.5	5	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	430	4	1	8	3.0	Cc1nc2n(c(=O)c1CCN1CCN(c3csc4ccsc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	5	139	None	45	Human	Functional	pEC50	=	7.5	7.5	-33	26	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.0c00814
	5202	139	None	45	Human	Functional	pEC50	=	7.5	7.5	-33	26	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.0c00814
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.5	7.5	-33	26	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.0c00814
	DB08839	139	None	45	Human	Functional	pEC50	=	7.5	7.5	-33	26	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.0c00814
	5	139	None	45	Human	Functional	pEC50	=	7.5	7.5	-33	26	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.9b00062
	5202	139	None	45	Human	Functional	pEC50	=	7.5	7.5	-33	26	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.9b00062
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.5	7.5	-33	26	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.9b00062
	DB08839	139	None	45	Human	Functional	pEC50	=	7.5	7.5	-33	26	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.9b00062
	10646934	101154	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	443	6	1	5	4.2	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(-n3cccn3)n2)CC1	10.1021/jm9806906
	CHEMBL295025	101154	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	443	6	1	5	4.2	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(-n3cccn3)n2)CC1	10.1021/jm9806906
	137635433	156028	None	0	Human	Functional	pEC50	=	6.5	6.5	-125	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	439	4	1	8	2.5	Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2(C)O	10.1016/j.bmc.2017.07.040
	CHEMBL4061068	156028	None	0	Human	Functional	pEC50	=	6.5	6.5	-125	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	439	4	1	8	2.5	Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2(C)O	10.1016/j.bmc.2017.07.040
	127051340	140299	None	0	Human	Functional	pEC50	=	6.5	6.5	-10	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	453	8	1	4	4.5	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1F	10.1016/j.bmcl.2016.04.087
	CHEMBL3805046	140299	None	0	Human	Functional	pEC50	=	6.5	6.5	-10	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	453	8	1	4	4.5	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1F	10.1016/j.bmcl.2016.04.087
	11339067	87617	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	417	7	1	3	5.5	CCCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3ncccc3c2C1	10.1016/j.bmcl.2007.03.049
	CHEMBL233591	87617	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	417	7	1	3	5.5	CCCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3ncccc3c2C1	10.1016/j.bmcl.2007.03.049
	44593729	179486	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	363	7	2	4	4.2	CCCNc1nccc(C2CCCN(CCc3c[nH]c4ccccc34)C2)n1	10.1016/j.bmcl.2008.12.087
	CHEMBL473902	179486	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	363	7	2	4	4.2	CCCNc1nccc(C2CCCN(CCc3c[nH]c4ccccc34)C2)n1	10.1016/j.bmcl.2008.12.087
	11741361	2830	None	36	Human	Functional	pEC50	=	6.5	6.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/acs.jmedchem.0c00814
	3924	2830	None	36	Human	Functional	pEC50	=	6.5	6.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/acs.jmedchem.0c00814
	CHEMBL230963	2830	None	36	Human	Functional	pEC50	=	6.5	6.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/acs.jmedchem.0c00814
	127049522	140291	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	435	8	1	4	4.3	CNC(=O)c1ccccc1OCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2016.04.087
	CHEMBL3804954	140291	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	435	8	1	4	4.3	CNC(=O)c1ccccc1OCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2016.04.087
	23625384	86401	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	409	6	2	5	3.0	CNc1ccnc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)n1	10.1021/jm070714l
	CHEMBL231373	86401	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	409	6	2	5	3.0	CNc1ccnc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)n1	10.1021/jm070714l
	10576554	172856	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	475	7	1	5	4.6	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CF)(CNCc2cccc(-n3cccn3)n2)CC1	10.1021/jm9806906
	CHEMBL45094	172856	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	475	7	1	5	4.6	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CF)(CNCc2cccc(-n3cccn3)n2)CC1	10.1021/jm9806906
	130431325	172515	None	0	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	439	8	1	4	5.0	CCc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1Cl	10.1021/acs.jmedchem.6b00860
	CHEMBL4476699	172515	None	0	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	439	8	1	4	5.0	CCc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1Cl	10.1021/acs.jmedchem.6b00860
	CHEMBL5077564	216994	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(CC6CCC6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	56850663	71528	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	375	7	1	5	2.1	O=C1C2CSCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926748	71528	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	375	7	1	5	2.1	O=C1C2CSCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962696	71528	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	375	7	1	5	2.1	O=C1C2CSCN2C(=O)N1CCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	1220	187	None	44	Human	Functional	pEC50	=	7.5	7.5	-1	9	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/acs.jmedchem.0c00814
	31	187	None	44	Human	Functional	pEC50	=	7.5	7.5	-1	9	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/acs.jmedchem.0c00814
	7	187	None	44	Human	Functional	pEC50	=	7.5	7.5	-1	9	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/acs.jmedchem.0c00814
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	7.5	7.5	-1	9	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/acs.jmedchem.0c00814
	1220	187	None	44	Human	Functional	pEC50	=	7.5	7.5	-1	9	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/acs.jmedchem.9b00062
	31	187	None	44	Human	Functional	pEC50	=	7.5	7.5	-1	9	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/acs.jmedchem.9b00062
	7	187	None	44	Human	Functional	pEC50	=	7.5	7.5	-1	9	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/acs.jmedchem.9b00062
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	7.5	7.5	-1	9	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/acs.jmedchem.9b00062
	44461162	208009	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	413	7	1	5	2.9	O=C(NCCCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL81095	208009	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	413	7	1	5	2.9	O=C(NCCCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	42606688	17860	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	381	5	1	5	2.8	Cc1ccc(CNCC2(F)CCN(C(=O)c3cnn4ccccc34)CC2)nc1	10.1021/jm100835q
	CHEMBL1259017	17860	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	381	5	1	5	2.8	Cc1ccc(CNCC2(F)CCN(C(=O)c3cnn4ccccc34)CC2)nc1	10.1021/jm100835q
	CHEMBL5089999	217726	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCN3CCN(C4=CC5CC(CC6CCN(Cc7ccccc7)CC6)C(=O)C5C=C4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	132256796	182905	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	454	8	1	4	4.6	COc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4790662	182905	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	454	8	1	4	4.6	COc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	10093856	77117	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	424	10	1	5	2.5	CC(=O)Nc1cccc(N2CCN(CCCCN(C)S(=O)(=O)CC(C)C)CC2)c1	10.1021/jm0508641
	CHEMBL207478	77117	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	424	10	1	5	2.5	CC(=O)Nc1cccc(N2CCN(CCCCN(C)S(=O)(=O)CC(C)C)CC2)c1	10.1021/jm0508641
	52943589	17920	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	371	5	2	5	2.7	Cc1ccc(CNCC2(O)CC3CCC(C2)N3C(=O)c2ccsc2)nc1	10.1021/jm100835q
	CHEMBL1259184	17920	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	371	5	2	5	2.7	Cc1ccc(CNCC2(O)CC3CCC(C2)N3C(=O)c2ccsc2)nc1	10.1021/jm100835q
	1220	187	None	44	Human	Functional	pEC50	=	7.5	7.5	-1	9	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm070714l
	31	187	None	44	Human	Functional	pEC50	=	7.5	7.5	-1	9	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm070714l
	7	187	None	44	Human	Functional	pEC50	=	7.5	7.5	-1	9	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm070714l
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	7.5	7.5	-1	9	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm070714l
	16109511	84286	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	377	8	1	3	5.5	CCC1(C)Cc2cccc(OCCNCc3cccc(C4=CCCC4)c3)c2O1	10.1021/jm061180b
	CHEMBL221131	84286	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	377	8	1	3	5.5	CCC1(C)Cc2cccc(OCCNCc3cccc(C4=CCCC4)c3)c2O1	10.1021/jm061180b
	132256760	183350	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	437	8	2	4	4.1	CNc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4796345	183350	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	437	8	2	4	4.1	CNc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	137658253	159724	None	0	Human	Functional	pEC50	=	7.5	7.5	1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	422	4	0	7	3.1	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2=O	10.1016/j.bmc.2017.07.040
	CHEMBL4103509	159724	None	0	Human	Functional	pEC50	=	7.5	7.5	1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	422	4	0	7	3.1	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2=O	10.1016/j.bmc.2017.07.040
	5	139	None	45	Rat	Functional	pEC50	=	6.5	6.5	-19	26	Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm800176x
	5202	139	None	45	Rat	Functional	pEC50	=	6.5	6.5	-19	26	Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm800176x
	CHEMBL39	139	None	45	Rat	Functional	pEC50	=	6.5	6.5	-19	26	Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm800176x
	DB08839	139	None	45	Rat	Functional	pEC50	=	6.5	6.5	-19	26	Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm800176x
	24949693	182410	None	0	Rat	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding	ChEMBL	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	10.1021/jm800176x
	CHEMBL478413	182410	None	0	Rat	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding	ChEMBL	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	10.1021/jm800176x
	CHEMBL5086277	217511	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6cccc(C(F)(F)F)c6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	208951	83077	None	29	Human	Functional	pEC50	=	6.5	6.5	-112	2	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	385	4	1	4	4.1	O=c1[nH]c2cccc(N3CCN(Cc4cccc(-c5ccccc5)c4)CC3)c2o1	10.1021/jm061180b
	CHEMBL218166	83077	None	29	Human	Functional	pEC50	=	6.5	6.5	-112	2	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	385	4	1	4	4.1	O=c1[nH]c2cccc(N3CCN(Cc4cccc(-c5ccccc5)c4)CC3)c2o1	10.1021/jm061180b
	44408882	75028	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	381	7	2	3	4.4	CC(C)CN1CC(CNCCc2c[nH]c3ccc(F)cc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	CHEMBL203282	75028	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	381	7	2	3	4.4	CC(C)CN1CC(CNCCc2c[nH]c3ccc(F)cc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	9799121	75539	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	363	7	2	3	4.4	CC(C)N1CC(CNCCCc2c[nH]c3ccccc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	CHEMBL204331	75539	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	363	7	2	3	4.4	CC(C)N1CC(CNCCCc2c[nH]c3ccccc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	10694238	101324	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	436	6	1	4	4.0	Cc1cc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc(N(C)C)c1	10.1021/jm9806906
	CHEMBL296289	101324	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	436	6	1	4	4.0	Cc1cc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc(N(C)C)c1	10.1021/jm9806906
	44408883	74735	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	321	5	2	3	3.2	CN1CC(CNCCc2c[nH]c3ccccc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	CHEMBL203067	74735	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	321	5	2	3	3.2	CN1CC(CNCCc2c[nH]c3ccccc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	9863750	83195	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	361	7	1	3	4.9	C1=C(c2cccc(CNCCOc3cccc4c3OC3(CC3)C4)c2)CCC1	10.1021/jm061180b
	CHEMBL218313	83195	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	361	7	1	3	4.9	C1=C(c2cccc(CNCCOc3cccc4c3OC3(CC3)C4)c2)CCC1	10.1021/jm061180b
	44537919	200592	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	CHEMBL574700	200592	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	132256814	180624	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	454	8	1	4	4.6	COc1ccc(OCCNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)cc1	10.1021/acs.jmedchem.0c00814
	CHEMBL4753394	180624	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	454	8	1	4	4.6	COc1ccc(OCCNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)cc1	10.1021/acs.jmedchem.0c00814
	11188024	145669	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	375	5	2	3	4.4	Fc1ccc2[nH]cc(CCCNC3COc4c(ccc5ncccc45)C3)c2c1	10.1016/j.bmcl.2007.03.049
	CHEMBL391531	145669	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	375	5	2	3	4.4	Fc1ccc2[nH]cc(CCCNC3COc4c(ccc5ncccc45)C3)c2c1	10.1016/j.bmcl.2007.03.049
	CHEMBL5076277	216914	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc(N2CCN(CCCCc3c[nH]c4ccccc34)CC2)cc1	10.1016/j.ejmech.2021.114045
	44408853	141306	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	373	5	2	3	4.0	CN1CC(CNCCc2c[nH]c3ccc(F)cc23)Oc2cc(Cl)ccc21	10.1016/j.bmcl.2005.11.054
	CHEMBL382857	141306	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	373	5	2	3	4.0	CN1CC(CNCCc2c[nH]c3ccc(F)cc23)Oc2cc(Cl)ccc21	10.1016/j.bmcl.2005.11.054
	46227762	202115	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	435	7	2	3	4.2	CCCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NCC3	10.1016/j.bmcl.2009.10.134
	CHEMBL592953	202115	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	435	7	2	3	4.2	CCCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NCC3	10.1016/j.bmcl.2009.10.134
	42606572	17859	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	381	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc4ccccc4o3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259016	17859	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	381	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc4ccccc4o3)CC2)nc1	10.1021/jm100835q
	129186549	158952	None	0	Human	Functional	pEC50	=	7.5	7.5	-4	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	423	4	1	6	4.0	Cc1nc2n(c(=O)c1CCN1CCC(c3cccc4sccc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	CHEMBL4094926	158952	None	0	Human	Functional	pEC50	=	7.5	7.5	-4	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	423	4	1	6	4.0	Cc1nc2n(c(=O)c1CCN1CCC(c3cccc4sccc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	56850924	71546	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	348	8	1	5	2.8	O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1926758	71546	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	348	8	1	5	2.8	O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	CHEMBL1962806	71546	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIAAgonist activity at human 5HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP production pretreated 20 mins before forskolin challenge measured after 2 hrs by RIA	ChEMBL	348	8	1	5	2.8	O=C1CSC(=O)N1CCCCCNCC1CCc2ccccc2O1	10.1021/jm2007886
	127049847	140405	None	0	Human	Functional	pEC50	=	7.5	7.5	1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	469	8	1	4	5.0	CNC(=O)c1cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1Cl	10.1016/j.bmcl.2016.04.087
	CHEMBL3806224	140405	None	0	Human	Functional	pEC50	=	7.5	7.5	1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	469	8	1	4	5.0	CNC(=O)c1cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1Cl	10.1016/j.bmcl.2016.04.087
	145961458	161492	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	492	6	2	6	4.8	N#Cc1ccc2[nH]cc(C(=O)CCCN3CCN(c4cccc5c(N)c6c(nc45)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	CHEMBL4126486	161492	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	492	6	2	6	4.8	N#Cc1ccc2[nH]cc(C(=O)CCCN3CCN(c4cccc5c(N)c6c(nc45)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	122183778	122312	None	0	Human	Functional	pEC50	=	6.5	6.5	-51	2	Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	434	8	2	6	2.5	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cnc3ccccc3c2)CC1	10.1021/acs.jmedchem.5b00776
	CHEMBL3597649	122312	None	0	Human	Functional	pEC50	=	6.5	6.5	-51	2	Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	434	8	2	6	2.5	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cnc3ccccc3c2)CC1	10.1021/acs.jmedchem.5b00776
	46230654	202894	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at 5HT1A receptor by GTPgammaS assayAgonist activity at 5HT1A receptor by GTPgammaS assay	ChEMBL	289	3	1	2	4.2	Fc1ccccc1Oc1cccc(F)c1C1CCNCC1	10.1016/j.bmcl.2009.12.023
	CHEMBL598346	202894	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at 5HT1A receptor by GTPgammaS assayAgonist activity at 5HT1A receptor by GTPgammaS assay	ChEMBL	289	3	1	2	4.2	Fc1ccccc1Oc1cccc(F)c1C1CCNCC1	10.1016/j.bmcl.2009.12.023
	46230654	202894	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay	ChEMBL	289	3	1	2	4.2	Fc1ccccc1Oc1cccc(F)c1C1CCNCC1	10.1016/j.bmcl.2010.11.066
	CHEMBL598346	202894	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay	ChEMBL	289	3	1	2	4.2	Fc1ccccc1Oc1cccc(F)c1C1CCNCC1	10.1016/j.bmcl.2010.11.066
	2965107	44967	None	5	Human	Functional	pEC50	=	4.5	4.5	-	1	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	314	5	3	2	2.7	O=C(O)C1CCCCC1C(=O)NCCc1c[nH]c2ccccc12	nan
	CHEMBL1523325	44967	None	5	Human	Functional	pEC50	=	4.5	4.5	-	1	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	314	5	3	2	2.7	O=C(O)C1CCCCC1C(=O)NCCc1c[nH]c2ccccc12	nan
	9881324	28380	None	3	Human	Functional	pEC50	=	7.5	7.5	1	4	Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.	ChEMBL	244	3	1	2	2.8	COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1	10.1021/jm00101a032
	CHEMBL137485	28380	None	3	Human	Functional	pEC50	=	7.5	7.5	1	4	Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.Effect on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.	ChEMBL	244	3	1	2	2.8	COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1	10.1021/jm00101a032
	11739995	18058	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	363	8	2	3	4.5	Fc1ccc2[nH]cc(CCCNCCOc3cccc4ncccc34)c2c1	10.1021/jm0304010
	CHEMBL126536	18058	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	363	8	2	3	4.5	Fc1ccc2[nH]cc(CCCNCCOc3cccc4ncccc34)c2c1	10.1021/jm0304010
	42606103	17901	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	361	5	1	4	3.5	Cc1ccc(CNCC2(F)CCN(C(=O)c3sccc3C)CC2)nc1	10.1021/jm100835q
	CHEMBL1259122	17901	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	361	5	1	4	3.5	Cc1ccc(CNCC2(F)CCN(C(=O)c3sccc3C)CC2)nc1	10.1021/jm100835q
	46225208	201924	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	433	6	2	3	4.3	O=C1NCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)C1CCC1)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL591561	201924	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	433	6	2	3	4.3	O=C1NCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)C1CCC1)CO3	10.1016/j.bmcl.2009.10.134
	130431296	174532	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	457	8	1	4	4.9	CCc1cccc(N2CCN(CC(F)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl	10.1021/acs.jmedchem.9b00607
	CHEMBL4553059	174532	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5-HT1A receptor (unknown origin) assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	457	8	1	4	4.9	CCc1cccc(N2CCN(CC(F)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl	10.1021/acs.jmedchem.9b00607
	CHEMBL5076629	216941	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4cccc5c4C(=O)C(CC4CCN(Cc6ccccc6)CC4)C5)CC3)c2c1	10.1016/j.ejmech.2021.114045
	15980808	202236	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	447	7	2	3	4.2	O=C1NCCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)CC1CC1)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL593865	202236	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	447	7	2	3	4.2	O=C1NCCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)CC1CC1)CO3	10.1016/j.bmcl.2009.10.134
	49782388	17870	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	495	5	1	3	3.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc4ccccc4[te]3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259036	17870	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	495	5	1	3	3.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc4ccccc4[te]3)CC2)nc1	10.1021/jm100835q
	127048532	140319	None	0	Human	Functional	pEC50	=	6.4	6.4	3	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	453	8	1	4	4.5	CNC(=O)c1cc(F)cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805262	140319	None	0	Human	Functional	pEC50	=	6.4	6.4	3	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	453	8	1	4	4.5	CNC(=O)c1cc(F)cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	23625381	86308	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	430	6	1	4	3.9	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2ncc(C(F)F)cn2)CC1	10.1021/jm070714l
	CHEMBL231272	86308	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	430	6	1	4	3.9	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2ncc(C(F)F)cn2)CC1	10.1021/jm070714l
	17371	170370	None	9	Human	Functional	pEC50	=	5.4	5.4	-	1	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	234	5	1	1	3.2	CCN(CC)CCc1c[nH]c2cc(F)ccc12	10.1021/jm000339w
	CHEMBL444612	170370	None	9	Human	Functional	pEC50	=	5.4	5.4	-	1	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	234	5	1	1	3.2	CCN(CC)CCc1c[nH]c2cc(F)ccc12	10.1021/jm000339w
	162644356	181884	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	380	7	0	5	2.1	O=C(c1ccccc1)N(CCCN1CCN(c2ccccn2)CC1)C1COC1	10.1016/j.ejmech.2020.112214
	CHEMBL4777749	181884	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	380	7	0	5	2.1	O=C(c1ccccc1)N(CCCN1CCN(c2ccccn2)CC1)C1COC1	10.1016/j.ejmech.2020.112214
	2477	745	None	38	Human	Functional	pEC50	=	7.4	7.4	-2	20	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.0c00814
	2477.0	745	None	38	Human	Functional	pEC50	=	7.4	7.4	-2	20	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.0c00814
	36	745	None	38	Human	Functional	pEC50	=	7.4	7.4	-2	20	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.0c00814
	437	745	None	38	Human	Functional	pEC50	=	7.4	7.4	-2	20	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.0c00814
	CHEMBL49	745	None	38	Human	Functional	pEC50	=	7.4	7.4	-2	20	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.0c00814
	DB00490	745	None	38	Human	Functional	pEC50	=	7.4	7.4	-2	20	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.0c00814
	132247308	181867	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	451	8	2	4	3.2	NC(=O)c1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4777581	181867	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	451	8	2	4	3.2	NC(=O)c1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	132257275	180739	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	425	7	1	4	4.0	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCCOc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4754941	180739	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	425	7	1	4	4.0	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCCOc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	9952481	141444	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	393	4	2	4	4.3	COc1cccc2c1OC(CN1CC=C(c3c[nH]c4ccc(F)cc34)CC1)CN2	10.1016/j.bmcl.2005.11.054
	CHEMBL383688	141444	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	393	4	2	4	4.3	COc1cccc2c1OC(CN1CC=C(c3c[nH]c4ccc(F)cc34)CC1)CN2	10.1016/j.bmcl.2005.11.054
	11741361	2830	None	36	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/jm070714l
	3924	2830	None	36	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/jm070714l
	CHEMBL230963	2830	None	36	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/jm070714l
	42606455	17897	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	403	5	1	5	4.4	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc4ccsc4s3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259109	17897	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	403	5	1	5	4.4	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc4ccsc4s3)CC2)nc1	10.1021/jm100835q
	145969406	164924	None	0	Rat	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assay	ChEMBL	498	7	0	6	4.7	CC(=O)c1c(OCCCN2CCN(c3ccccc3Br)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.bmc.2017.12.016
	CHEMBL4218720	164924	None	0	Rat	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assay	ChEMBL	498	7	0	6	4.7	CC(=O)c1c(OCCCN2CCN(c3ccccc3Br)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.bmc.2017.12.016
	132247302	180567	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(F)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4752833	180567	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(F)c2)CC1	10.1021/acs.jmedchem.0c00814
	10600032	172647	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	459	6	2	6	3.3	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(O)(CNCc2cccc(-n3cccn3)n2)CC1	10.1021/jm9806906
	CHEMBL44841	172647	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	459	6	2	6	3.3	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(O)(CNCc2cccc(-n3cccn3)n2)CC1	10.1021/jm9806906
	44433258	89116	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS bindingAntagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	302	7	3	3	3.2	OC(CCNC1CCCCC1)COc1cccc2[nH]ccc12	10.1016/j.bmcl.2007.07.086
	CHEMBL236518	89116	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS bindingAntagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	302	7	3	3	3.2	OC(CCNC1CCCCC1)COc1cccc2[nH]ccc12	10.1016/j.bmcl.2007.07.086
	5	139	None	45	Human	Functional	pEC50	=	6.4	6.4	-33	26	Agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assayAgonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2022.114218
	5202	139	None	45	Human	Functional	pEC50	=	6.4	6.4	-33	26	Agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assayAgonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2022.114218
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	6.4	6.4	-33	26	Agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assayAgonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2022.114218
	DB08839	139	None	45	Human	Functional	pEC50	=	6.4	6.4	-33	26	Agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assayAgonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2022.114218
	15980853	202523	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	411	5	3	3	3.3	O=C1NCCc2cc(F)c3c(c21)CC(NCCCc1c[nH]c2ccc(F)cc12)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL595744	202523	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	411	5	3	3	3.3	O=C1NCCc2cc(F)c3c(c21)CC(NCCCc1c[nH]c2ccc(F)cc12)CO3	10.1016/j.bmcl.2009.10.134
	11313610	117918	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	333	8	3	2	4.3	c1ccc2c(CCCNCCOc3cccc4[nH]ccc34)c[nH]c2c1	10.1021/jm0304010
	CHEMBL340301	117918	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	333	8	3	2	4.3	c1ccc2c(CCCNCCOc3cccc4[nH]ccc34)c[nH]c2c1	10.1021/jm0304010
	162662080	181525	None	0	Human	Functional	pEC50	=	8.4	8.4	6	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	466	6	1	5	3.7	O=C1NCC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)c2cc(F)ccc21	10.1016/j.ejmech.2020.112572
	CHEMBL4763837	181525	None	0	Human	Functional	pEC50	=	8.4	8.4	6	3	Agonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader methodAgonist activity at 5-HT1A receptor (unknown origin) preincubated for 60 mins followed by addition of Eu-cAMP and measured after 60 mins by plate reader method	ChEMBL	466	6	1	5	3.7	O=C1NCC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)c2cc(F)ccc21	10.1016/j.ejmech.2020.112572
	127049864	140369	None	0	Human	Functional	pEC50	=	8.4	8.4	2	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cccc(OCCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805860	140369	None	0	Human	Functional	pEC50	=	8.4	8.4	2	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cccc(OCCCCN2CCN(c3nsc4ccccc34)CC2)c1	10.1016/j.bmcl.2016.04.087
	129186554	157910	None	0	Human	Functional	pEC50	=	8.3	8.3	-3	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	408	4	0	6	3.5	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2	10.1016/j.bmc.2017.07.040
	CHEMBL4083333	157910	None	0	Human	Functional	pEC50	=	8.3	8.3	-3	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	408	4	0	6	3.5	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2	10.1016/j.bmc.2017.07.040
	9950482	117090	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	354	8	2	3	3.8	Fc1ccc2[nH]cc(CCCNCCOc3cccc4c3OCC4)c2c1	10.1021/jm0304010
	CHEMBL338982	117090	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	354	8	2	3	3.8	Fc1ccc2[nH]cc(CCCNCCOc3cccc4c3OCC4)c2c1	10.1021/jm0304010
	44591319	189821	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	379	8	2	5	3.4	COCCNc1nccc(C2CCCN(CCc3c[nH]c4ccccc34)C2)n1	10.1016/j.bmcl.2008.12.087
	CHEMBL515573	189821	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	379	8	2	5	3.4	COCCNc1nccc(C2CCCN(CCc3c[nH]c4ccccc34)C2)n1	10.1016/j.bmcl.2008.12.087
	132256734	179673	None	1	Human	Functional	pEC50	=	7.4	7.4	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	408	7	1	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4741857	179673	None	1	Human	Functional	pEC50	=	7.4	7.4	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	408	7	1	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL5087878	217614	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccccc4C(=O)CCC4CCN(Cc5ccccc5)CC4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	10692801	168011	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	407	6	1	3	4.2	CCc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm9806906
	CHEMBL431332	168011	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	407	6	1	3	4.2	CCc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm9806906
	2477	745	None	38	Human	Functional	pEC50	=	7.4	7.4	-2	20	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2008.12.087
	2477.0	745	None	38	Human	Functional	pEC50	=	7.4	7.4	-2	20	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2008.12.087
	36	745	None	38	Human	Functional	pEC50	=	7.4	7.4	-2	20	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2008.12.087
	437	745	None	38	Human	Functional	pEC50	=	7.4	7.4	-2	20	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2008.12.087
	CHEMBL49	745	None	38	Human	Functional	pEC50	=	7.4	7.4	-2	20	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2008.12.087
	DB00490	745	None	38	Human	Functional	pEC50	=	7.4	7.4	-2	20	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/j.bmcl.2008.12.087
	11221557	18046	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	342	9	2	3	3.9	COc1ccccc1OCCNCCCc1c[nH]c2ccc(F)cc12	10.1021/jm0304010
	CHEMBL126484	18046	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	342	9	2	3	3.9	COc1ccccc1OCCNCCCc1c[nH]c2ccc(F)cc12	10.1021/jm0304010
	9953959	75312	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	421	5	1	4	4.7	CCN1CC(CN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)Oc2c(OC)cccc21	10.1016/j.bmcl.2005.11.054
	CHEMBL203726	75312	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	421	5	1	4	4.7	CCN1CC(CN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)Oc2c(OC)cccc21	10.1016/j.bmcl.2005.11.054
	42606105	17900	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	361	5	1	4	3.5	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(C)s3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259121	17900	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	361	5	1	4	3.5	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(C)s3)CC2)nc1	10.1021/jm100835q
	145976348	163836	None	0	Human	Functional	pEC50	=	7.4	7.4	1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	443	8	1	7	3.2	CNC(=O)c1cncc(OCCCCN2CCN(c3nsc4cc(F)ccc34)CC2)c1	10.1016/j.bmcl.2018.01.038
	CHEMBL4205326	163836	None	0	Human	Functional	pEC50	=	7.4	7.4	1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	443	8	1	7	3.2	CNC(=O)c1cncc(OCCCCN2CCN(c3nsc4cc(F)ccc34)CC2)c1	10.1016/j.bmcl.2018.01.038
	23625534	151386	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	443	6	2	5	3.7	CNc1nc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)ncc1Cl	10.1021/jm070714l
	CHEMBL396062	151386	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	443	6	2	5	3.7	CNc1nc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)ncc1Cl	10.1021/jm070714l
	132257061	180133	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	426	7	1	3	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccc(F)cc2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4747425	180133	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	426	7	1	3	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccc(F)cc2)CC1	10.1021/acs.jmedchem.0c00814
	168295509	192623	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins by TR-FRET assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins by TR-FRET assay	ChEMBL	449	6	1	8	3.0	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5O)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5209283	192623	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins by TR-FRET assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins by TR-FRET assay	ChEMBL	449	6	1	8	3.0	COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5O)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	122183765	122300	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	452	8	1	5	4.2	COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cnc3ccccc3c2)CC1	10.1021/acs.jmedchem.5b00776
	CHEMBL3597637	122300	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	452	8	1	5	4.2	COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cnc3ccccc3c2)CC1	10.1021/acs.jmedchem.5b00776
	5	139	None	45	Human	Functional	pEC50	=	7.4	7.4	-33	26	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pigCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pig	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/0960-894X(95)00417-R
	5202	139	None	45	Human	Functional	pEC50	=	7.4	7.4	-33	26	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pigCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pig	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/0960-894X(95)00417-R
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.4	7.4	-33	26	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pigCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pig	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/0960-894X(95)00417-R
	DB08839	139	None	45	Human	Functional	pEC50	=	7.4	7.4	-33	26	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pigCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pig	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/0960-894X(95)00417-R
	132247307	180516	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	481	8	2	4	4.6	CC(=O)Nc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4752177	180516	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	481	8	2	4	4.6	CC(=O)Nc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	46225263	202160	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	483	6	2	3	4.6	O=C1NCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)C(=O)c1ccccc1)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL593281	202160	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	483	6	2	3	4.6	O=C1NCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)C(=O)c1ccccc1)CO3	10.1016/j.bmcl.2009.10.134
	11313754	16854	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	338	10	2	3	4.2	COc1ccccc1OCCNCCCCc1c[nH]c2ccccc12	10.1021/jm0304010
	CHEMBL124818	16854	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	338	10	2	3	4.2	COc1ccccc1OCCNCCCCc1c[nH]c2ccccc12	10.1021/jm0304010
	53248258	62057	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	441	8	1	5	4.2	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm200288r
	CHEMBL1774538	62057	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	441	8	1	5	4.2	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm200288r
	23626164	86400	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	410	6	1	5	3.0	COc1ccnc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)n1	10.1021/jm070714l
	CHEMBL231372	86400	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	410	6	1	5	3.0	COc1ccnc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)n1	10.1021/jm070714l
	24944943	102565	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	381	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12	10.1021/jm400766k
	CHEMBL2431038	102565	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	381	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12	10.1021/jm400766k
	CHEMBL3040400	102565	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	381	9	1	4	3.0	O=C1C2CCCN2C(=O)N1CCCCNCCOc1cccc2ccccc12	10.1021/jm400766k
	164619127	185631	None	0	Human	Functional	pEC50	=	7.3	7.3	-8	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	428	10	2	4	4.8	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2	10.1021/acs.jmedchem.1c01327
	CHEMBL4862770	185631	None	0	Human	Functional	pEC50	=	7.3	7.3	-8	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	428	10	2	4	4.8	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2	10.1021/acs.jmedchem.1c01327
	132256759	179694	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	409	7	1	4	3.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccnc2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4742122	179694	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	409	7	1	4	3.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccnc2)CC1	10.1021/acs.jmedchem.9b00062
	164619127	185631	None	0	Human	Functional	pEC50	=	7.3	7.3	-8	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	428	10	2	4	4.8	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2	10.1021/acs.jmedchem.1c01327
	CHEMBL4862770	185631	None	0	Human	Functional	pEC50	=	7.3	7.3	-8	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	428	10	2	4	4.8	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2	10.1021/acs.jmedchem.1c01327
	137660385	159181	None	0	Human	Functional	pEC50	=	6.4	6.4	-22	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	425	4	1	8	2.4	Cc1nc2n(c(=O)c1CCN1CCN(c3nccc4sccc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	CHEMBL4097395	159181	None	0	Human	Functional	pEC50	=	6.4	6.4	-22	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	425	4	1	8	2.4	Cc1nc2n(c(=O)c1CCN1CCN(c3nccc4sccc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	162648066	179949	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	433	8	0	3	5.1	CCCN(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)C(=O)c1ccccc1	10.1016/j.ejmech.2020.112214
	CHEMBL4745192	179949	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	433	8	0	3	5.1	CCCN(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)C(=O)c1ccccc1	10.1016/j.ejmech.2020.112214
	11394411	17863	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	364	8	2	4	3.9	Fc1ccc2[nH]cc(CCCNCCOc3cccc4nccnc34)c2c1	10.1021/jm0304010
	CHEMBL125902	17863	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	364	8	2	4	3.9	Fc1ccc2[nH]cc(CCCNCCOc3cccc4nccnc34)c2c1	10.1021/jm0304010
	42605992	17906	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	381	5	1	4	3.8	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(Cl)s3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259138	17906	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	381	5	1	4	3.8	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(Cl)s3)CC2)nc1	10.1021/jm100835q
	162652689	180571	None	0	Human	Functional	pEC50	=	7.3	7.3	11	3	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	433	7	0	3	5.1	CC(C)N(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)C(=O)c1ccccc1	10.1016/j.ejmech.2020.112214
	CHEMBL4752859	180571	None	0	Human	Functional	pEC50	=	7.3	7.3	11	3	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	433	7	0	3	5.1	CC(C)N(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)C(=O)c1ccccc1	10.1016/j.ejmech.2020.112214
	16109484	84388	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	365	9	1	3	5.6	CC(C)Oc1ccccc1OCCNCc1cccc(C2=CCCCC2)c1	10.1021/jm061180b
	CHEMBL221743	84388	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	365	9	1	3	5.6	CC(C)Oc1ccccc1OCCNCc1cccc(C2=CCCCC2)c1	10.1021/jm061180b
	132256713	182576	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	407	7	1	3	4.0	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCCc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4786537	182576	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	407	7	1	3	4.0	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCCc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	11722647	207880	None	0	Human	Functional	pEC50	=	6.3	6.3	-41	4	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pigCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pig	ChEMBL	305	4	1	4	3.0	CN(C)CCc1c[nH]c2ccc(-n3cnc4cccnc43)cc12	10.1016/0960-894X(95)00417-R
	CHEMBL80189	207880	None	0	Human	Functional	pEC50	=	6.3	6.3	-41	4	Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pigCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pig	ChEMBL	305	4	1	4	3.0	CN(C)CCc1c[nH]c2ccc(-n3cnc4cccnc43)cc12	10.1016/0960-894X(95)00417-R
	164937988	195320	None	4	Human	Functional	pEC50	=	5.3	5.3	-169	5	Agonist activity at 5-HT1A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT1A receptor (unknown origin) by calcium flux assay	ChEMBL	338	5	0	5	3.4	c1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	CHEMBL5400876	195320	None	4	Human	Functional	pEC50	=	5.3	5.3	-169	5	Agonist activity at 5-HT1A receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT1A receptor (unknown origin) by calcium flux assay	ChEMBL	338	5	0	5	3.4	c1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	127051040	140366	None	0	Human	Functional	pEC50	=	6.3	6.3	-28	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	491	12	1	4	5.9	CCCCCNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805826	140366	None	0	Human	Functional	pEC50	=	6.3	6.3	-28	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	491	12	1	4	5.9	CCCCCNC(=O)c1cccc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL5078629	217061	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccoc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	5487088	208305	None	32	Rat	Functional	pEC50	=	7.3	7.3	-19	2	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	351	5	2	5	3.9	CN1CCC[C@@H]1Cc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12	10.1021/jm00042a003
	CHEMBL83597	208305	None	32	Rat	Functional	pEC50	=	7.3	7.3	-19	2	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	351	5	2	5	3.9	CN1CCC[C@@H]1Cc1c[nH]c2ccc(Nc3ncccc3[N+](=O)[O-])cc12	10.1021/jm00042a003
	52945241	17933	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	385	5	1	3	3.6	Cc1ccc(CNCC2(F)CCN(C(=O)C34CC5CC(CC3C5)C4)CC2)nc1	10.1021/jm100835q
	CHEMBL1259223	17933	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	385	5	1	3	3.6	Cc1ccc(CNCC2(F)CCN(C(=O)C34CC5CC(CC3C5)C4)CC2)nc1	10.1021/jm100835q
	132256759	179694	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	409	7	1	4	3.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccnc2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4742122	179694	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	409	7	1	4	3.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccnc2)CC1	10.1021/acs.jmedchem.9b00062
	44290346	177480	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	436	6	1	4	4.0	Cc1ccc(N(C)C)nc1CNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/jm9806906
	CHEMBL46379	177480	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	436	6	1	4	4.0	Cc1ccc(N(C)C)nc1CNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/jm9806906
	145986552	166838	None	0	Human	Functional	pEC50	=	7.3	7.3	11	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	453	6	0	5	4.8	O=C1c2ccc(Cl)cc2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4283369	166838	None	0	Human	Functional	pEC50	=	7.3	7.3	11	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	453	6	0	5	4.8	O=C1c2ccc(Cl)cc2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	132257112	183470	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4797752	183470	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.0c00814
	168281650	191311	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assay	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)cc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	CHEMBL5189417	191311	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assay	ChEMBL	467	6	0	7	3.9	COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)cc5)CC4)C3)c2cc1OC	10.1016/j.ejmech.2022.114218
	155535272	172134	None	0	Human	Functional	pEC50	=	7.3	7.3	4	2	Agonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	280	5	0	2	3.8	CCCCN1CCN(c2cccc(CC)c2Cl)CC1	10.1021/acs.jmedchem.6b00860
	CHEMBL4471669	172134	None	0	Human	Functional	pEC50	=	7.3	7.3	4	2	Agonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	280	5	0	2	3.8	CCCCN1CCN(c2cccc(CC)c2Cl)CC1	10.1021/acs.jmedchem.6b00860
	52946036	17934	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	433	5	1	3	4.4	Cc1ccc(CNCC2(F)CCN(C(=O)C34CC5CC(CC(Cl)(C5)C3)C4)CC2)nc1	10.1021/jm100835q
	CHEMBL1259224	17934	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	433	5	1	3	4.4	Cc1ccc(CNCC2(F)CCN(C(=O)C34CC5CC(CC(Cl)(C5)C3)C4)CC2)nc1	10.1021/jm100835q
	137659145	159530	None	0	Human	Functional	pEC50	=	6.3	6.3	-58	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	443	4	0	7	3.6	Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2Cl	10.1016/j.bmc.2017.07.040
	CHEMBL4101115	159530	None	0	Human	Functional	pEC50	=	6.3	6.3	-58	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	443	4	0	7	3.6	Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2Cl	10.1016/j.bmc.2017.07.040
	46224739	201569	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	447	8	2	3	4.6	O=C1NCc2ccc3c(c21)CC(N(CCCCc1c[nH]c2ccc(F)cc12)CC1CC1)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL589141	201569	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	447	8	2	3	4.6	O=C1NCc2ccc3c(c21)CC(N(CCCCc1c[nH]c2ccc(F)cc12)CC1CC1)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL5088366	217644	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(CC6CCCC6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	10813865	178126	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	460	6	1	5	5.2	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(-c3nccs3)n2)CC1	10.1021/jm9806906
	CHEMBL46467	178126	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	460	6	1	5	5.2	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(-c3nccs3)n2)CC1	10.1021/jm9806906
	127049866	140358	None	1	Human	Functional	pEC50	=	8.3	8.3	17	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	423	8	1	5	4.2	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc4sccc34)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3805704	140358	None	1	Human	Functional	pEC50	=	8.3	8.3	17	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	423	8	1	5	4.2	CNC(=O)c1cccc(OCCCCN2CCN(c3cccc4sccc34)CC2)c1	10.1016/j.bmcl.2016.04.087
	10765698	165339	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	443	6	1	4	5.3	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(-c3ccco3)n2)CC1	10.1021/jm9806906
	CHEMBL42294	165339	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	443	6	1	4	5.3	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(-c3ccco3)n2)CC1	10.1021/jm9806906
	10091417	208014	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	384	6	0	5	3.4	O=C(CCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL543377	208014	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	384	6	0	5	3.4	O=C(CCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL81118	208014	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	384	6	0	5	3.4	O=C(CCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	5	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-33	26	Agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in calcium flux by fluorimetric methodAgonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in calcium flux by fluorimetric method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	5202	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-33	26	Agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in calcium flux by fluorimetric methodAgonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in calcium flux by fluorimetric method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-33	26	Agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in calcium flux by fluorimetric methodAgonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in calcium flux by fluorimetric method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	DB08839	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-33	26	Agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in calcium flux by fluorimetric methodAgonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in calcium flux by fluorimetric method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	10047814	104920	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	421	6	0	6	2.7	O=C1c2ccccc2C(=O)N1CCCCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	CHEMBL311015	104920	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	421	6	0	6	2.7	O=C1c2ccccc2C(=O)N1CCCCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	10764513	101239	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	418	6	1	4	3.8	Cc1ccc(C(=O)N2CCC(F)(CNCc3cccc(N(C)C)n3)CC2)cc1Cl	10.1021/jm9806906
	CHEMBL295662	101239	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	418	6	1	4	3.8	Cc1ccc(C(=O)N2CCC(F)(CNCc3cccc(N(C)C)n3)CC2)cc1Cl	10.1021/jm9806906
	10575934	166237	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	459	6	1	4	5.8	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(-c3cccs3)n2)CC1	10.1021/jm9806906
	CHEMBL42618	166237	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	459	6	1	4	5.8	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(-c3cccs3)n2)CC1	10.1021/jm9806906
	145992523	167109	None	0	Human	Functional	pEC50	=	8.2	8.2	5	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	453	6	0	5	4.8	O=C1c2cccc(Cl)c2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4288388	167109	None	0	Human	Functional	pEC50	=	8.2	8.2	5	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	453	6	0	5	4.8	O=C1c2cccc(Cl)c2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	5	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-33	26	Agonist activity at human 5HT1A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT1A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2020.112709
	5202	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-33	26	Agonist activity at human 5HT1A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT1A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2020.112709
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-33	26	Agonist activity at human 5HT1A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT1A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2020.112709
	DB08839	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-33	26	Agonist activity at human 5HT1A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT1A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2020.112709
	1220	187	None	44	Human	Functional	pEC50	=	8.2	8.2	-1	9	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm000339w
	31	187	None	44	Human	Functional	pEC50	=	8.2	8.2	-1	9	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm000339w
	7	187	None	44	Human	Functional	pEC50	=	8.2	8.2	-1	9	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm000339w
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	8.2	8.2	-1	9	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm000339w
	9887537	84379	None	31	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm061180b
	CHEMBL221692	84379	None	31	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm061180b
	CHEMBL4751170	84379	None	31	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm061180b
	156021805	178260	None	0	Human	Functional	pEC50	=	8.2	8.2	24	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	432	6	0	8	3.2	N#Cc1ccn2c(=O)n(CCCCN3CCN(c4cccc5sccc45)CC3)nc2c1	10.1016/j.bmcl.2020.127027
	CHEMBL4648979	178260	None	0	Human	Functional	pEC50	=	8.2	8.2	24	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	432	6	0	8	3.2	N#Cc1ccn2c(=O)n(CCCCN3CCN(c4cccc5sccc45)CC3)nc2c1	10.1016/j.bmcl.2020.127027
	9999722	164277	None	0	Human	Functional	pEC50	=	7.3	7.3	-112	2	Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 50-550Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 50-550	ChEMBL	378	6	2	4	2.4	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12	10.1016/0960-894X(95)00091-7
	CHEMBL421064	164277	None	0	Human	Functional	pEC50	=	7.3	7.3	-112	2	Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 50-550Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 50-550	ChEMBL	378	6	2	4	2.4	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4ccccc4)CC3)cc12	10.1016/0960-894X(95)00091-7
	42606335	17925	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	411	6	1	5	3.8	COc1c(C(=O)N2CCC(F)(CNCc3ccc(C)cn3)CC2)csc1Cl	10.1021/jm100835q
	CHEMBL1259198	17925	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	411	6	1	5	3.8	COc1c(C(=O)N2CCC(F)(CNCc3ccc(C)cn3)CC2)csc1Cl	10.1021/jm100835q
	5	139	None	45	Human	Functional	pEC50	=	7.3	7.3	-33	26	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.9b00062
	5202	139	None	45	Human	Functional	pEC50	=	7.3	7.3	-33	26	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.9b00062
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.3	7.3	-33	26	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.9b00062
	DB08839	139	None	45	Human	Functional	pEC50	=	7.3	7.3	-33	26	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.9b00062
	44591317	180756	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	379	8	3	5	3.2	OCCCNc1nccc(C2CCCN(CCc3c[nH]c4ccccc34)C2)n1	10.1016/j.bmcl.2008.12.087
	CHEMBL475502	180756	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	379	8	3	5	3.2	OCCCNc1nccc(C2CCCN(CCc3c[nH]c4ccccc34)C2)n1	10.1016/j.bmcl.2008.12.087
	164619170	185707	None	0	Human	Functional	pEC50	=	7.3	7.3	-15	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4863832	185707	None	0	Human	Functional	pEC50	=	7.3	7.3	-15	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	6088	119906	None	24	Human	Functional	pEC50	=	5.3	5.3	-100	2	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	174	3	2	1	1.9	CNCCc1c[nH]c2ccccc12	nan
	CHEMBL348588	119906	None	24	Human	Functional	pEC50	=	5.3	5.3	-100	2	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	174	3	2	1	1.9	CNCCc1c[nH]c2ccccc12	nan
	145962091	161428	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	464	5	2	5	4.8	N#Cc1ccc2[nH]cc(CCCN3CCN(c4cccc5nc6c(c(N)c45)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	CHEMBL4125732	161428	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	464	5	2	5	4.8	N#Cc1ccc2[nH]cc(CCCN3CCN(c4cccc5nc6c(c(N)c45)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	49781928	17919	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	391	5	1	3	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc4ccccc4c3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259181	17919	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	391	5	1	3	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc4ccccc4c3)CC2)nc1	10.1021/jm100835q
	11515921	76573	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	355	6	3	4	3.3	COc1cccc2c1OC(CNCCc1c[nH]c3ccc(F)cc13)CN2	10.1016/j.bmcl.2005.11.054
	CHEMBL206130	76573	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	355	6	3	4	3.3	COc1cccc2c1OC(CNCCc1c[nH]c3ccc(F)cc13)CN2	10.1016/j.bmcl.2005.11.054
	164619170	185707	None	0	Human	Functional	pEC50	=	7.3	7.3	-15	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4863832	185707	None	0	Human	Functional	pEC50	=	7.3	7.3	-15	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	10015045	13657	None	0	Rat	Functional	pEC50	=	5.3	5.3	-91	3	Ability to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptamine 1A receptorAbility to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptamine 1A receptor	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00004a011
	CHEMBL119455	13657	None	0	Rat	Functional	pEC50	=	5.3	5.3	-91	3	Ability to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptamine 1A receptorAbility to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptamine 1A receptor	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00004a011
	CHEMBL5069928	216711	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)CC(CC4CCN(Cc6ccccc6)CC4)C5=O)CC3)c2c1	10.1016/j.ejmech.2021.114045
	132257112	183470	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4797752	183470	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.0c00814
	132256800	182900	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	478	7	1	4	4.8	CC1(C)Cc2cccc(OCCNCC3(F)CCN(C(=O)c4ccc(F)c(Cl)c4)CC3)c2O1	10.1021/acs.jmedchem.0c00814
	CHEMBL4790600	182900	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	478	7	1	4	4.8	CC1(C)Cc2cccc(OCCNCC3(F)CCN(C(=O)c4ccc(F)c(Cl)c4)CC3)c2O1	10.1021/acs.jmedchem.0c00814
	15980809	202302	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	447	6	2	3	4.4	O=C1NCCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)C1CCC1)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL594357	202302	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	447	6	2	3	4.4	O=C1NCCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)C1CCC1)CO3	10.1016/j.bmcl.2009.10.134
	42606106	17911	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	393	6	1	5	3.9	CSc1ccc(C(=O)N2CCC(F)(CNCc3ccc(C)cn3)CC2)s1	10.1021/jm100835q
	CHEMBL1259153	17911	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	393	6	1	5	3.9	CSc1ccc(C(=O)N2CCC(F)(CNCc3ccc(C)cn3)CC2)s1	10.1021/jm100835q
	162654486	180718	None	0	Human	Functional	pEC50	=	7.3	7.3	125	3	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	366	8	0	4	3.1	CCCN(CCCN1CCN(c2ccccn2)CC1)C(=O)c1ccccc1	10.1016/j.ejmech.2020.112214
	CHEMBL4754651	180718	None	0	Human	Functional	pEC50	=	7.3	7.3	125	3	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	366	8	0	4	3.1	CCCN(CCCN1CCN(c2ccccn2)CC1)C(=O)c1ccccc1	10.1016/j.ejmech.2020.112214
	132256715	179515	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	408	7	2	4	3.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCNc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4740097	179515	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	408	7	2	4	3.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCNc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL5072034	216761	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6cccnc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	132256811	180049	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2Cl)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4746386	180049	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2Cl)CC1	10.1021/acs.jmedchem.0c00814
	3082625	194840	None	4	Rat	Functional	pEC50	=	7.3	7.3	-	1	Ability to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptamine 1A receptorAbility to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptamine 1A receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00004a011
	CHEMBL53510	194840	None	4	Rat	Functional	pEC50	=	7.3	7.3	-	1	Ability to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptamine 1A receptorAbility to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptamine 1A receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00004a011
	46180192	204533	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	291	3	0	2	4.0	C=CCOc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm9015763
	CHEMBL608728	204533	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	291	3	0	2	4.0	C=CCOc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm9015763
	155529450	171540	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5 HT1A receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by TR-FRET assayAgonist activity at human 5 HT1A receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by TR-FRET assay	ChEMBL	495	8	0	5	4.2	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2019.126667
	CHEMBL4463030	171540	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5 HT1A receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by TR-FRET assayAgonist activity at human 5 HT1A receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by TR-FRET assay	ChEMBL	495	8	0	5	4.2	O=C1c2ccccc2S(=O)(=O)N1CCCCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2019.126667
	11164569	118246	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	370	8	2	3	4.8	Fc1cc(OCCNCCCc2c[nH]c3ccc(F)cc23)c2occc2c1	10.1021/jm0304010
	CHEMBL340895	118246	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	370	8	2	3	4.8	Fc1cc(OCCNCCCc2c[nH]c3ccc(F)cc23)c2occc2c1	10.1021/jm0304010
	132256806	180111	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	438	8	1	4	4.1	COc1ccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)cc1	10.1021/acs.jmedchem.0c00814
	CHEMBL4747083	180111	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	438	8	1	4	4.1	COc1ccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)cc1	10.1021/acs.jmedchem.0c00814
	145963420	161583	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	492	6	2	6	4.8	N#Cc1ccc2[nH]cc(C(=O)CCCN3CCN(c4ccc5c(N)c6c(nc5c4)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	CHEMBL4127877	161583	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	492	6	2	6	4.8	N#Cc1ccc2[nH]cc(C(=O)CCCN3CCN(c4ccc5c(N)c6c(nc5c4)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	CHEMBL5071558	216749	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)C(=O)C(CC4CCN(Cc6ccccc6)CC4)C5)CC3)c2c1	10.1016/j.ejmech.2021.114045
	CHEMBL5082250	217283	None	2	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccccc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	164628178	186453	None	0	Human	Functional	pEC50	=	7.2	7.2	-15	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4875081	186453	None	0	Human	Functional	pEC50	=	7.2	7.2	-15	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	5	139	None	45	Human	Functional	pEC50	=	7.2	7.2	-33	26	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.0c00814
	5202	139	None	45	Human	Functional	pEC50	=	7.2	7.2	-33	26	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.0c00814
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.2	7.2	-33	26	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.0c00814
	DB08839	139	None	45	Human	Functional	pEC50	=	7.2	7.2	-33	26	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.0c00814
	164628178	186453	None	0	Human	Functional	pEC50	=	7.2	7.2	-15	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4875081	186453	None	0	Human	Functional	pEC50	=	7.2	7.2	-15	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	162677207	183664	None	0	Human	Functional	pEC50	=	6.2	6.2	3	3	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	447	7	0	4	4.0	O=C(c1ccccc1)N(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)C1COC1	10.1016/j.ejmech.2020.112214
	CHEMBL4800286	183664	None	0	Human	Functional	pEC50	=	6.2	6.2	3	3	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	447	7	0	4	4.0	O=C(c1ccccc1)N(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)C1COC1	10.1016/j.ejmech.2020.112214
	42606456	17902	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	437	5	1	5	5.1	Cc1ccc(CNCC2(F)CCN(C(=O)c3sc4sccc4c3Cl)CC2)nc1	10.1021/jm100835q
	CHEMBL1259123	17902	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	437	5	1	5	5.1	Cc1ccc(CNCC2(F)CCN(C(=O)c3sc4sccc4c3Cl)CC2)nc1	10.1021/jm100835q
	72699716	115253	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	3	Agonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assay	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	CHEMBL3344459	115253	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	3	Agonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assay	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	172456322	196371	None	0	Rat	Functional	pEC50	=	8.2	8.2	1905	2	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	603	9	0	6	5.4	COc1ccccc1N1CCN(CCCCN2C(=O)C3C(C2=O)C2(C)C(=O)C3(C)C(c3ccccc3)=C2c2ccccc2)CC1	10.1016/j.bmc.2023.117518
	CHEMBL5422403	196371	None	0	Rat	Functional	pEC50	=	8.2	8.2	1905	2	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	603	9	0	6	5.4	COc1ccccc1N1CCN(CCCCN2C(=O)C3C(C2=O)C2(C)C(=O)C3(C)C(c3ccccc3)=C2c2ccccc2)CC1	10.1016/j.bmc.2023.117518
	1220	187	None	44	Human	Functional	pEC50	=	8.2	8.2	-1	9	Agonist activity at human 5 HT1A receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by TR-FRET assayAgonist activity at human 5 HT1A receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by TR-FRET assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2019.126667
	31	187	None	44	Human	Functional	pEC50	=	8.2	8.2	-1	9	Agonist activity at human 5 HT1A receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by TR-FRET assayAgonist activity at human 5 HT1A receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by TR-FRET assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2019.126667
	7	187	None	44	Human	Functional	pEC50	=	8.2	8.2	-1	9	Agonist activity at human 5 HT1A receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by TR-FRET assayAgonist activity at human 5 HT1A receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by TR-FRET assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2019.126667
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	8.2	8.2	-1	9	Agonist activity at human 5 HT1A receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by TR-FRET assayAgonist activity at human 5 HT1A receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by TR-FRET assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1016/j.bmcl.2019.126667
	127048539	140350	None	0	Human	Functional	pEC50	=	8.2	8.2	7	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	441	8	1	5	4.4	CNC(=O)c1cc(OCCCCN2CCN(c3cccc4sccc34)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
	CHEMBL3805649	140350	None	0	Human	Functional	pEC50	=	8.2	8.2	7	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	441	8	1	5	4.4	CNC(=O)c1cc(OCCCCN2CCN(c3cccc4sccc34)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
	132247303	180365	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	451	8	2	4	3.2	NC(=O)c1ccccc1OCCNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4750444	180365	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	451	8	2	4	3.2	NC(=O)c1ccccc1OCCNCC1(F)CCN(C(=O)c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.0c00814
	10405775	104964	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	352	6	0	4	3.6	c1ccc(CCCCN2CCN(c3cccc4c3OCCO4)CC2)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL311275	104964	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	352	6	0	4	3.6	c1ccc(CCCCN2CCN(c3cccc4c3OCCO4)CC2)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL543139	104964	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	352	6	0	4	3.6	c1ccc(CCCCN2CCN(c3cccc4c3OCCO4)CC2)cc1	10.1016/s0960-894x(98)00406-5
	145989451	167391	None	0	Human	Functional	pEC50	=	8.2	8.2	-3	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	459	6	0	6	2.7	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3c2OC(F)(F)O3)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4293718	167391	None	0	Human	Functional	pEC50	=	8.2	8.2	-3	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	459	6	0	6	2.7	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3c2OC(F)(F)O3)CC1	10.1016/j.ejmech.2017.12.099
	145978208	163633	None	0	Human	Functional	pEC50	=	8.2	8.2	10	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	451	9	1	7	3.6	O=C(NC1CC1)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4202871	163633	None	0	Human	Functional	pEC50	=	8.2	8.2	10	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	451	9	1	7	3.6	O=C(NC1CC1)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	16109486	137444	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	351	7	1	4	4.2	C1=C(c2cccc(CNCCOc3cccc4c3OCCO4)c2)CCC1	10.1021/jm061180b
	CHEMBL375297	137444	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	351	7	1	4	4.2	C1=C(c2cccc(CNCCOc3cccc4c3OCCO4)c2)CCC1	10.1021/jm061180b
	49780603	17912	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	391	5	2	4	2.9	Cc1ccc(CNCC2(O)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259155	17912	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	391	5	2	4	2.9	Cc1ccc(CNCC2(O)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm100835q
	132256800	182900	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	478	7	1	4	4.8	CC1(C)Cc2cccc(OCCNCC3(F)CCN(C(=O)c4ccc(F)c(Cl)c4)CC3)c2O1	10.1021/acs.jmedchem.0c00814
	CHEMBL4790600	182900	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	478	7	1	4	4.8	CC1(C)Cc2cccc(OCCNCC3(F)CCN(C(=O)c4ccc(F)c(Cl)c4)CC3)c2O1	10.1021/acs.jmedchem.0c00814
	1	1650	None	7	Human	Functional	pEC50	=	8.2	8.2	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cellsCompound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells	ChEMBL	415	6	2	6	1.5	OC[C@H]1COc2c(O1)cccc2N1CCN(CC1)CCNC(=O)c1ccc(cc1)F	10.1016/s0960-894x(98)00406-5
	57347	1650	None	7	Human	Functional	pEC50	=	8.2	8.2	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cellsCompound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells	ChEMBL	415	6	2	6	1.5	OC[C@H]1COc2c(O1)cccc2N1CCN(CC1)CCNC(=O)c1ccc(cc1)F	10.1016/s0960-894x(98)00406-5
	CHEMBL1742477	1650	None	7	Human	Functional	pEC50	=	8.2	8.2	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cellsCompound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells	ChEMBL	415	6	2	6	1.5	OC[C@H]1COc2c(O1)cccc2N1CCN(CC1)CCNC(=O)c1ccc(cc1)F	10.1016/s0960-894x(98)00406-5
	10670050	169361	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	424	6	2	4	4.2	CNc1cccc(CNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1021/jm9806906
	CHEMBL44118	169361	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	424	6	2	4	4.2	CNc1cccc(CNCC2(F)CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1021/jm9806906
	10405775	104964	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	352	6	0	4	3.6	c1ccc(CCCCN2CCN(c3cccc4c3OCCO4)CC2)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL311275	104964	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	352	6	0	4	3.6	c1ccc(CCCCN2CCN(c3cccc4c3OCCO4)CC2)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL543139	104964	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)	ChEMBL	352	6	0	4	3.6	c1ccc(CCCCN2CCN(c3cccc4c3OCCO4)CC2)cc1	10.1016/s0960-894x(98)00406-5
	145990794	166896	None	0	Human	Functional	pEC50	=	8.2	8.2	-1	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	437	6	0	5	3.8	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4284346	166896	None	0	Human	Functional	pEC50	=	8.2	8.2	-1	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	437	6	0	5	3.8	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	10047196	140055	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	410	10	2	5	2.1	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC(C)C)CC2)c1	10.1021/jm0508641
	CHEMBL379984	140055	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	410	10	2	5	2.1	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC(C)C)CC2)c1	10.1021/jm0508641
	11741361	2830	None	36	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/acs.jmedchem.0c00814
	3924	2830	None	36	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/acs.jmedchem.0c00814
	CHEMBL230963	2830	None	36	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/acs.jmedchem.0c00814
	11741361	2830	None	36	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/acs.jmedchem.9b00062
	3924	2830	None	36	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/acs.jmedchem.9b00062
	CHEMBL230963	2830	None	36	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	394	5	1	4	3.3	Cc1cnc(nc1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F	10.1021/acs.jmedchem.9b00062
	9862968	18003	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	344	8	2	2	4.9	c1ccc2c(OCCNCCCc3c[nH]c4ccccc34)cccc2c1	10.1021/jm0304010
	CHEMBL126253	18003	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	344	8	2	2	4.9	c1ccc2c(OCCNCCCc3c[nH]c4ccccc34)cccc2c1	10.1021/jm0304010
	53248210	62051	None	0	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	455	9	1	6	3.7	COc1ccc2oc(C(=O)NCCC(F)CN3CCN(c4ccccc4OC)CC3)cc2c1	10.1021/jm200288r
	CHEMBL1774532	62051	None	0	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	455	9	1	6	3.7	COc1ccc2oc(C(=O)NCCC(F)CN3CCN(c4ccccc4OC)CC3)cc2c1	10.1021/jm200288r
	172452097	195742	None	0	Rat	Functional	pEC50	=	6.2	6.2	40	2	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	607	8	0	5	6.1	CC12C(=O)C(C)(C(c3ccccc3)=C1c1ccccc1)C1C(=O)N(CCCCN3CCN(c4cccc(Cl)c4)CC3)C(=O)C12	10.1016/j.bmc.2023.117518
	CHEMBL5409943	195742	None	0	Rat	Functional	pEC50	=	6.2	6.2	40	2	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	607	8	0	5	6.1	CC12C(=O)C(C)(C(c3ccccc3)=C1c1ccccc1)C1C(=O)N(CCCCN3CCN(c4cccc(Cl)c4)CC3)C(=O)C12	10.1016/j.bmc.2023.117518
	52947712	17852	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	415	5	2	4	3.1	Cc1ccc(CNCC2(F)CCN(C(=O)C34CC5CC(CC(O)(C5)C3)C4)CC2)nc1	10.1021/jm100835q
	CHEMBL1258996	17852	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	415	5	2	4	3.1	Cc1ccc(CNCC2(F)CCN(C(=O)C34CC5CC(CC(O)(C5)C3)C4)CC2)nc1	10.1021/jm100835q
	137651544	157566	None	0	Human	Functional	pEC50	=	6.2	6.2	-17	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	409	4	0	7	2.9	Cc1nc2n(c(=O)c1CCN1CCN(c3nccc4sccc34)CC1)CCCC2	10.1016/j.bmc.2017.07.040
	CHEMBL4079365	157566	None	0	Human	Functional	pEC50	=	6.2	6.2	-17	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	409	4	0	7	2.9	Cc1nc2n(c(=O)c1CCN1CCN(c3nccc4sccc34)CC1)CCCC2	10.1016/j.bmc.2017.07.040
	132256806	180111	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	438	8	1	4	4.1	COc1ccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)cc1	10.1021/acs.jmedchem.0c00814
	CHEMBL4747083	180111	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	438	8	1	4	4.1	COc1ccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)cc1	10.1021/acs.jmedchem.0c00814
	CHEMBL5071820	216757	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccccc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	16092107	202389	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	379	5	3	3	3.1	O=C1NCc2ccc3c(c21)CC(NCCCc1c[nH]c2ccc(F)cc12)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL594829	202389	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	379	5	3	3	3.1	O=C1NCc2ccc3c(c21)CC(NCCCc1c[nH]c2ccc(F)cc12)CO3	10.1016/j.bmcl.2009.10.134
	42606336	17149	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	455	6	1	5	4.0	COc1c(C(=O)N2CCC(F)(CNCc3ccc(C)cn3)CC2)csc1Br	10.1021/jm100835q
	CHEMBL1255610	17149	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	455	6	1	5	4.0	COc1c(C(=O)N2CCC(F)(CNCc3ccc(C)cn3)CC2)csc1Br	10.1021/jm100835q
	145960493	161654	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	492	6	2	6	4.8	N#Cc1ccc2[nH]cc(C(=O)CCCN3CCN(c4cccc5nc6c(c(N)c45)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	CHEMBL4128838	161654	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	492	6	2	6	4.8	N#Cc1ccc2[nH]cc(C(=O)CCCN3CCN(c4cccc5nc6c(c(N)c45)CCCC6)CC3)c2c1	10.1016/j.bmc.2018.04.037
	11339067	87617	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	417	7	1	3	5.5	CCCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3ncccc3c2C1	10.1016/j.bmcl.2007.03.049
	CHEMBL233591	87617	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	417	7	1	3	5.5	CCCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3ncccc3c2C1	10.1016/j.bmcl.2007.03.049
	42606458	17889	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	483	5	1	6	3.7	Cc1ccc(CNCC2(F)CCN(C(=O)c3sc(Br)c4c3OCCO4)CC2)nc1	10.1021/jm100835q
	CHEMBL1259090	17889	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	483	5	1	6	3.7	Cc1ccc(CNCC2(F)CCN(C(=O)c3sc(Br)c4c3OCCO4)CC2)nc1	10.1021/jm100835q
	132256734	179673	None	1	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	408	7	1	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4741857	179673	None	1	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	408	7	1	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2)CC1	10.1021/acs.jmedchem.0c00814
	5022	1651	None	58	Human	Functional	pEC50	=	6.2	6.2	6	9	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1021/jm070714l
	6918248	1651	None	58	Human	Functional	pEC50	=	6.2	6.2	6	9	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1021/jm070714l
	6918248.0	1651	None	58	Human	Functional	pEC50	=	6.2	6.2	6	9	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1021/jm070714l
	8182	1651	None	58	Human	Functional	pEC50	=	6.2	6.2	6	9	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1021/jm070714l
	CHEMBL231068	1651	None	58	Human	Functional	pEC50	=	6.2	6.2	6	9	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1021/jm070714l
	DB04908	1651	None	58	Human	Functional	pEC50	=	6.2	6.2	6	9	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1021/jm070714l
	145973003	164629	None	0	Rat	Functional	pEC50	=	6.2	6.2	-	1	Antagonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes assessed as inhibition of 8-OH-DPAT-induced receptor activation after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assayAntagonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes assessed as inhibition of 8-OH-DPAT-induced receptor activation after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assay	ChEMBL	450	8	0	7	3.9	COc1ccccc1N1CCN(CCCOc2ccc3c(C)cc(=O)oc3c2C(C)=O)CC1	10.1016/j.bmc.2017.12.016
	CHEMBL4215022	164629	None	0	Rat	Functional	pEC50	=	6.2	6.2	-	1	Antagonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes assessed as inhibition of 8-OH-DPAT-induced receptor activation after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assayAntagonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes assessed as inhibition of 8-OH-DPAT-induced receptor activation after 90 mins by microbeta scintillation counting based [35S]GTPgammaS binding assay	ChEMBL	450	8	0	7	3.9	COc1ccccc1N1CCN(CCCOc2ccc3c(C)cc(=O)oc3c2C(C)=O)CC1	10.1016/j.bmc.2017.12.016
	44461160	105484	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	429	4	0	7	1.4	O=C1c2ccccc2S(=O)(=O)N1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	CHEMBL311976	105484	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	429	4	0	7	1.4	O=C1c2ccccc2S(=O)(=O)N1CCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	132247302	180567	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(F)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4752833	180567	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	442	7	1	3	4.7	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(F)c2)CC1	10.1021/acs.jmedchem.0c00814
	44591318	179584	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	393	9	2	5	3.8	COCCCNc1nccc(C2CCCN(CCc3c[nH]c4ccccc34)C2)n1	10.1016/j.bmcl.2008.12.087
	CHEMBL474090	179584	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	393	9	2	5	3.8	COCCCNc1nccc(C2CCCN(CCc3c[nH]c4ccccc34)C2)n1	10.1016/j.bmcl.2008.12.087
	CHEMBL5072039	216762	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(CC6CCCCC6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	CHEMBL5082836	217315	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccccc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	CHEMBL5091978	217827	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)C/C(=C\C4CCN(Cc6ccccc6)CC4)C5=O)CC3)c2c1	10.1016/j.ejmech.2021.114045
	132257069	181162	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	425	7	1	4	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCSc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4759629	181162	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	425	7	1	4	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCSc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL5088143	217631	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccsc6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	16109482	142006	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	367	9	1	4	5.4	CC(C)Oc1ccccc1OCCNCc1cccc(-c2ccsc2)c1	10.1021/jm061180b
	CHEMBL386988	142006	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	367	9	1	4	5.4	CC(C)Oc1ccccc1OCCNCc1cccc(-c2ccsc2)c1	10.1021/jm061180b
	42	2063	None	41	Human	Functional	pEC50	=	7.2	7.2	-4	10	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cellsCompound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/s0960-894x(98)00406-5
	56971	2063	None	41	Human	Functional	pEC50	=	7.2	7.2	-4	10	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cellsCompound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/s0960-894x(98)00406-5
	CHEMBL8412	2063	None	41	Human	Functional	pEC50	=	7.2	7.2	-4	10	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cellsCompound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1016/s0960-894x(98)00406-5
	137640522	157180	None	0	Human	Functional	pEC50	=	6.2	6.2	-87	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	427	4	0	7	3.3	Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2F	10.1016/j.bmc.2017.07.040
	CHEMBL4074373	157180	None	0	Human	Functional	pEC50	=	6.2	6.2	-87	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	427	4	0	7	3.3	Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2F	10.1016/j.bmc.2017.07.040
	6090	34576	None	10	Human	Functional	pEC50	=	6.2	6.2	-	1	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	216	5	1	1	3.1	CCN(CC)CCc1c[nH]c2ccccc12	10.1021/jm000339w
	CHEMBL142936	34576	None	10	Human	Functional	pEC50	=	6.2	6.2	-	1	EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorEC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	216	5	1	1	3.1	CCN(CC)CCc1c[nH]c2ccccc12	10.1021/jm000339w
	5	139	None	45	Human	Functional	pEC50	=	7.2	7.2	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2017.05.047
	5202	139	None	45	Human	Functional	pEC50	=	7.2	7.2	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2017.05.047
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.2	7.2	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2017.05.047
	DB08839	139	None	45	Human	Functional	pEC50	=	7.2	7.2	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2017.05.047
	10024776	166175	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	413	5	1	3	4.3	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2ccc(Cl)cn2)CC1	10.1021/jm070714l
	CHEMBL425833	166175	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	413	5	1	3	4.3	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCc2ccc(Cl)cn2)CC1	10.1021/jm070714l
	16109496	84174	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	351	9	1	3	5.2	CC(C)Oc1ccccc1OCCNCc1cccc(C2=CCCC2)c1	10.1021/jm061180b
	CHEMBL220809	84174	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	351	9	1	3	5.2	CC(C)Oc1ccccc1OCCNCc1cccc(C2=CCCC2)c1	10.1021/jm061180b
	138692460	179501	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	426	7	1	3	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(F)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4739908	179501	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	426	7	1	3	4.2	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(F)c2)CC1	10.1021/acs.jmedchem.0c00814
	137656381	159853	None	0	Human	Functional	pEC50	=	7.2	7.2	33	2	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	425	4	1	8	2.4	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4scnc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	CHEMBL4105102	159853	None	0	Human	Functional	pEC50	=	7.2	7.2	33	2	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	425	4	1	8	2.4	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4scnc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	156015516	177668	None	0	Human	Functional	pEC50	=	8.2	8.2	14	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	485	6	0	7	4.1	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2c(Br)cccn12	10.1016/j.bmcl.2020.127027
	CHEMBL4640409	177668	None	0	Human	Functional	pEC50	=	8.2	8.2	14	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	485	6	0	7	4.1	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2c(Br)cccn12	10.1016/j.bmcl.2020.127027
	2810280	182882	None	2	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	476	8	1	3	5.2	O=C(CN1CCN(CCCc2c[nH]c3ccc(F)cc23)CC1)N(c1ccccc1)C1CCCCC1	10.1016/j.ejmech.2020.112214
	CHEMBL4790303	182882	None	2	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	476	8	1	3	5.2	O=C(CN1CCN(CCCc2c[nH]c3ccc(F)cc23)CC1)N(c1ccccc1)C1CCCCC1	10.1016/j.ejmech.2020.112214
	2810280	182882	None	2	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at recombinant 5HT1A receptor (unknown origin) expressed in CHO cell membrane assessed as [35S]GTPgammaS binding by liquid scintillation counting methodAgonist activity at recombinant 5HT1A receptor (unknown origin) expressed in CHO cell membrane assessed as [35S]GTPgammaS binding by liquid scintillation counting method	ChEMBL	476	8	1	3	5.2	O=C(CN1CCN(CCCc2c[nH]c3ccc(F)cc23)CC1)N(c1ccccc1)C1CCCCC1	10.1016/j.ejmech.2020.112214
	CHEMBL4790303	182882	None	2	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at recombinant 5HT1A receptor (unknown origin) expressed in CHO cell membrane assessed as [35S]GTPgammaS binding by liquid scintillation counting methodAgonist activity at recombinant 5HT1A receptor (unknown origin) expressed in CHO cell membrane assessed as [35S]GTPgammaS binding by liquid scintillation counting method	ChEMBL	476	8	1	3	5.2	O=C(CN1CCN(CCCc2c[nH]c3ccc(F)cc23)CC1)N(c1ccccc1)C1CCCCC1	10.1016/j.ejmech.2020.112214
	10025854	101590	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	432	6	1	4	4.2	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(N3CCC3)n2)CC1	10.1021/jm9806906
	CHEMBL298260	101590	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	432	6	1	4	4.2	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(CNCc2cccc(N3CCC3)n2)CC1	10.1021/jm9806906
	129186544	161168	None	0	Human	Functional	pEC50	=	8.2	8.2	-2	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	444	4	0	6	4.0	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2(F)F	10.1016/j.bmc.2017.07.040
	CHEMBL4087132	161168	None	0	Human	Functional	pEC50	=	8.2	8.2	-2	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	444	4	0	6	4.0	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2(F)F	10.1016/j.bmc.2017.07.040
	CHEMBL4116744	161168	None	0	Human	Functional	pEC50	=	8.2	8.2	-2	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	444	4	0	6	4.0	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2(F)F	10.1016/j.bmc.2017.07.040
	3251	4072	None	43	Human	Functional	pEC50	=	8.2	8.2	-3	4	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm0304010
	5684	4072	None	43	Human	Functional	pEC50	=	8.2	8.2	-3	4	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm0304010
	80	4072	None	43	Human	Functional	pEC50	=	8.2	8.2	-3	4	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm0304010
	CHEMBL31354	4072	None	43	Human	Functional	pEC50	=	8.2	8.2	-3	4	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm0304010
	129186534	159790	None	0	Human	Functional	pEC50	=	8.1	8.1	-2	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	426	4	0	6	3.9	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2F	10.1016/j.bmc.2017.07.040
	CHEMBL4104261	159790	None	0	Human	Functional	pEC50	=	8.1	8.1	-2	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	426	4	0	6	3.9	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2F	10.1016/j.bmc.2017.07.040
	127049515	140372	None	0	Human	Functional	pEC50	=	8.1	8.1	5	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	453	8	1	4	4.5	CNC(=O)c1cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
	CHEMBL3805884	140372	None	0	Human	Functional	pEC50	=	8.1	8.1	5	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	453	8	1	4	4.5	CNC(=O)c1cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
	10091417	208014	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	384	6	0	5	3.4	O=C(CCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL543377	208014	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	384	6	0	5	3.4	O=C(CCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL81118	208014	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)	ChEMBL	384	6	0	5	3.4	O=C(CCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1016/s0960-894x(98)00406-5
	145993493	167453	None	0	Human	Functional	pEC50	=	8.1	8.1	3	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	439	6	0	5	4.5	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4294617	167453	None	0	Human	Functional	pEC50	=	8.1	8.1	3	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	439	6	0	5	4.5	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	124	2981	None	32	Human	Functional	pEC50	=	7.2	7.2	-12	24	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	2032	2981	None	32	Human	Functional	pEC50	=	7.2	7.2	-12	24	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	4636	2981	None	32	Human	Functional	pEC50	=	7.2	7.2	-12	24	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	4636.0	2981	None	32	Human	Functional	pEC50	=	7.2	7.2	-12	24	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	CHEMBL762	2981	None	32	Human	Functional	pEC50	=	7.2	7.2	-12	24	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	DB00935	2981	None	32	Human	Functional	pEC50	=	7.2	7.2	-12	24	PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]PUBCHEM_BIOASSAY: Dose Response assay for agonists of 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1A (5HT1A). (Class of assay: confirmatory) [Related pubchem assays: 567, 574 ]	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	138692457	182539	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	438	8	1	4	4.1	COc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4786067	182539	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	438	8	1	4	4.1	COc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	172469973	197043	None	0	Rat	Functional	pEC50	=	6.2	6.2	72	2	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	574	8	0	6	4.8	CC12C(=O)C(C)(C(c3ccccc3)=C1c1ccccc1)C1C(=O)N(CCCCN3CCN(c4ccccn4)CC3)C(=O)C12	10.1016/j.bmc.2023.117518
	CHEMBL5437394	197043	None	0	Rat	Functional	pEC50	=	6.2	6.2	72	2	Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysisAgonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins by scintillation counter analysis	ChEMBL	574	8	0	6	4.8	CC12C(=O)C(C)(C(c3ccccc3)=C1c1ccccc1)C1C(=O)N(CCCCN3CCN(c4ccccn4)CC3)C(=O)C12	10.1016/j.bmc.2023.117518
	53248158	62008	None	0	Human	Functional	pEC50	=	7.1	7.1	7	2	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	462	9	1	5	4.0	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2ccc(-c3ccccn3)cc2)CC1	10.1021/jm200288r
	CHEMBL1774383	62008	None	0	Human	Functional	pEC50	=	7.1	7.1	7	2	Agonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at 5HT1A receptor assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	462	9	1	5	4.0	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2ccc(-c3ccccn3)cc2)CC1	10.1021/jm200288r
	2477	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.0c00814
	2477.0	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.0c00814
	36	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.0c00814
	437	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.0c00814
	CHEMBL49	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.0c00814
	DB00490	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.0c00814
	2477	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.9b00062
	2477.0	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.9b00062
	36	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.9b00062
	437	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.9b00062
	CHEMBL49	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.9b00062
	DB00490	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/acs.jmedchem.9b00062
	132247309	179546	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	476	7	1	3	5.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(C(F)(F)F)c2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4740430	179546	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobilization measured for 30 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay	ChEMBL	476	7	1	3	5.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc(C(F)(F)F)c2)CC1	10.1021/acs.jmedchem.0c00814
	127051041	140307	None	0	Human	Functional	pEC50	=	7.1	7.1	-7	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	449	8	1	4	4.6	CNC(=O)c1cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1C	10.1016/j.bmcl.2016.04.087
	CHEMBL3805120	140307	None	0	Human	Functional	pEC50	=	7.1	7.1	-7	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	449	8	1	4	4.6	CNC(=O)c1cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1C	10.1016/j.bmcl.2016.04.087
	132256715	179515	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	408	7	2	4	3.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCNc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4740097	179515	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	408	7	2	4	3.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCNc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	71574210	86317	None	0	Human	Functional	pEC50	=	5.1	5.1	-2	2	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312934	86317	None	0	Human	Functional	pEC50	=	5.1	5.1	-2	2	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	478	7	1	5	4.0	O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	46225165	201973	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	393	5	2	3	3.4	CN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NC3	10.1016/j.bmcl.2009.10.134
	CHEMBL592028	201973	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	393	5	2	3	3.4	CN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NC3	10.1016/j.bmcl.2009.10.134
	24944944	102566	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	331	9	1	4	1.9	O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1	10.1021/jm400766k
	CHEMBL2431146	102566	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	331	9	1	4	1.9	O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1	10.1021/jm400766k
	CHEMBL3040401	102566	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	331	9	1	4	1.9	O=C1C2CCCN2C(=O)N1CCCCNCCOc1ccccc1	10.1021/jm400766k
	129186541	161300	None	0	Human	Functional	pEC50	=	7.1	7.1	-14	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	407	4	0	5	4.5	Cc1nc2n(c(=O)c1CCN1CCC(c3cccc4sccc34)CC1)CCCC2	10.1016/j.bmc.2017.07.040
	CHEMBL4078409	161300	None	0	Human	Functional	pEC50	=	7.1	7.1	-14	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	407	4	0	5	4.5	Cc1nc2n(c(=O)c1CCN1CCC(c3cccc4sccc34)CC1)CCCC2	10.1016/j.bmc.2017.07.040
	CHEMBL4117823	161300	None	0	Human	Functional	pEC50	=	7.1	7.1	-14	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	407	4	0	5	4.5	Cc1nc2n(c(=O)c1CCN1CCC(c3cccc4sccc34)CC1)CCCC2	10.1016/j.bmc.2017.07.040
	130431277	170035	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	2	Agonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	224	2	1	2	2.3	CCc1cccc(N2CCNCC2)c1Cl	10.1021/acs.jmedchem.6b00860
	CHEMBL4441358	170035	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	2	Agonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	224	2	1	2	2.3	CCc1cccc(N2CCNCC2)c1Cl	10.1021/acs.jmedchem.6b00860
	53319432	57157	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay	ChEMBL	325	4	1	3	4.2	Fc1cccc(Cl)c1Oc1cccc(F)c1O[C@@H]1CCNC1	10.1016/j.bmcl.2010.11.066
	CHEMBL1645617	57157	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at 5HT1A receptor by GTPgammaS binding assayAgonist activity at 5HT1A receptor by GTPgammaS binding assay	ChEMBL	325	4	1	3	4.2	Fc1cccc(Cl)c1Oc1cccc(F)c1O[C@@H]1CCNC1	10.1016/j.bmcl.2010.11.066
	6918388	84173	None	24	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	348	5	1	3	4.4	Fc1ccc(-c2cncc(CNC[C@H]3CCc4ccccc4O3)c2)cc1	10.1021/jm061180b
	CHEMBL220808	84173	None	24	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human 5HT1A receptor in HeLa cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	348	5	1	3	4.4	Fc1ccc(-c2cncc(CNC[C@H]3CCc4ccccc4O3)c2)cc1	10.1021/jm061180b
	137646568	158041	None	0	Human	Functional	pEC50	=	6.1	6.1	-120	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	423	4	0	8	2.5	Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2=O	10.1016/j.bmc.2017.07.040
	CHEMBL4084663	158041	None	0	Human	Functional	pEC50	=	6.1	6.1	-120	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	423	4	0	8	2.5	Cc1nc2n(c(=O)c1CCN1CCN(c3nsc4ccccc34)CC1)CCCC2=O	10.1016/j.bmc.2017.07.040
	44593729	179486	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	363	7	2	4	4.2	CCCNc1nccc(C2CCCN(CCc3c[nH]c4ccccc34)C2)n1	10.1016/j.bmcl.2008.12.087
	CHEMBL473902	179486	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by FLIPRAgonist activity at human 5HT1A receptor expressed in CHO cells by FLIPR	ChEMBL	363	7	2	4	4.2	CCCNc1nccc(C2CCCN(CCc3c[nH]c4ccccc34)C2)n1	10.1016/j.bmcl.2008.12.087
	213	3853	None	34	Human	Functional	pEC50	=	6.1	6.1	-33	21	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1016/j.bmcl.2020.127027
	2717	3853	None	34	Human	Functional	pEC50	=	6.1	6.1	-33	21	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1016/j.bmcl.2020.127027
	5533	3853	None	34	Human	Functional	pEC50	=	6.1	6.1	-33	21	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1016/j.bmcl.2020.127027
	5533.0	3853	None	34	Human	Functional	pEC50	=	6.1	6.1	-33	21	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1016/j.bmcl.2020.127027
	CHEMBL621	3853	None	34	Human	Functional	pEC50	=	6.1	6.1	-33	21	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1016/j.bmcl.2020.127027
	DB00656	3853	None	34	Human	Functional	pEC50	=	6.1	6.1	-33	21	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1016/j.bmcl.2020.127027
	132256764	180698	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	406	7	1	2	4.6	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCCc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4754363	180698	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	406	7	1	2	4.6	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCCc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	10453264	86125	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	394	5	1	4	3.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nn1	10.1021/jm070714l
	CHEMBL230961	86125	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	394	5	1	4	3.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nn1	10.1021/jm070714l
	1220	187	None	44	Human	Functional	pEC50	=	8.1	8.1	-1	9	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm400766k
	31	187	None	44	Human	Functional	pEC50	=	8.1	8.1	-1	9	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm400766k
	7	187	None	44	Human	Functional	pEC50	=	8.1	8.1	-1	9	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm400766k
	CHEMBL56	187	None	44	Human	Functional	pEC50	=	8.1	8.1	-1	9	Agonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIAAgonist activity at human 5-HT1A receptor expressed in human HeLa cells assessed as inhibition of forskolin-stimulated cAMP formation after 10 mins by RIA	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm400766k
	132256734	179673	None	1	Human	Functional	pEC50	=	8.1	8.1	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	408	7	1	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4741857	179673	None	1	Human	Functional	pEC50	=	8.1	8.1	-	1	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	408	7	1	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2)CC1	10.1021/acs.jmedchem.0c00814
	132256734	179673	None	1	Human	Functional	pEC50	=	8.1	8.1	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	408	7	1	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4741857	179673	None	1	Human	Functional	pEC50	=	8.1	8.1	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	408	7	1	3	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	127048540	140292	None	0	Human	Functional	pEC50	=	8.1	8.1	3	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	465	8	1	6	3.5	CNC(=O)c1cc(OCCCCN2CCN(c3cccc4c3OC(F)(F)O4)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
	CHEMBL3804965	140292	None	0	Human	Functional	pEC50	=	8.1	8.1	3	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	465	8	1	6	3.5	CNC(=O)c1cc(OCCCCN2CCN(c3cccc4c3OC(F)(F)O4)CC2)ccc1F	10.1016/j.bmcl.2016.04.087
	10550911	178992	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	436	7	2	4	4.3	CCNc1nc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)ccc1C	10.1021/jm9806906
	CHEMBL46984	178992	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	436	7	2	4	4.3	CCNc1nc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)ccc1C	10.1021/jm9806906
	CHEMBL5087461	217590	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		C=CCN1CCC(CCC(=O)c2ccc(N3CCN(CCCCc4c[nH]c5ccc(C#N)cc45)CC3)cc2)CC1	10.1016/j.ejmech.2021.114045
	49780600	17903	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	407	5	0	3	4.3	Cc1ccc(CN(C)CC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259124	17903	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	407	5	0	3	4.3	Cc1ccc(CN(C)CC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm100835q
	5	139	None	45	Human	Functional	pEC50	=	8.1	8.1	-33	26	Binding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-SBinding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-S	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
	5202	139	None	45	Human	Functional	pEC50	=	8.1	8.1	-33	26	Binding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-SBinding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-S	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.1	8.1	-33	26	Binding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-SBinding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-S	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
	DB08839	139	None	45	Human	Functional	pEC50	=	8.1	8.1	-33	26	Binding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-SBinding affinity against human 5-hydroxytryptamine 1A receptors HEK 293 cell membranes using [35S]GTP gamma-S	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0341204
	145988497	167287	None	0	Human	Functional	pEC50	=	8.1	8.1	-7	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	411	6	0	5	3.6	O=C1C2CCCC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4291387	167287	None	0	Human	Functional	pEC50	=	8.1	8.1	-7	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	411	6	0	5	3.6	O=C1C2CCCC2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	132256735	180616	None	13	Human	Functional	pEC50	=	8.1	8.1	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	409	7	1	4	3.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4753328	180616	None	13	Human	Functional	pEC50	=	8.1	8.1	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	409	7	1	4	3.5	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	10695395	171747	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	462	6	1	5	4.8	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3cnco3)n2)CC1	10.1021/jm9806906
	CHEMBL44659	171747	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptorIn vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor	ChEMBL	462	6	1	5	4.8	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCc2cccc(-c3cnco3)n2)CC1	10.1021/jm9806906
	2477	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm0508641
	2477.0	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm0508641
	36	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm0508641
	437	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm0508641
	CHEMBL49	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm0508641
	DB00490	745	None	38	Human	Functional	pEC50	=	7.1	7.1	-2	20	Activity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assayActivity against 5HT1A receptor by Gi-[35S]GTP-gamma-S binding assay	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm0508641
	44373641	120303	None	0	Human	Functional	pEC50	=	7.1	7.1	-354	2	Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 85-370Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 85-370	ChEMBL	408	7	2	5	2.4	COc1cccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)c1	10.1016/0960-894X(95)00091-7
	CHEMBL352234	120303	None	0	Human	Functional	pEC50	=	7.1	7.1	-354	2	Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 85-370Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; value ranges from 85-370	ChEMBL	408	7	2	5	2.4	COc1cccc(N2CCN(C(=O)COc3ccc4[nH]cc(CCN)c4c3)CC2)c1	10.1016/0960-894X(95)00091-7
	23625533	149551	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	423	6	2	5	3.4	CNc1nc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)ncc1C	10.1021/jm070714l
	CHEMBL394606	149551	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	423	6	2	5	3.4	CNc1nc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)ncc1C	10.1021/jm070714l
	132256764	180698	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	406	7	1	2	4.6	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCCc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4754363	180698	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured at 2 sec intervals for 180 secs by Fluo-4AM dye based fluorescence assay	ChEMBL	406	7	1	2	4.6	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCCc2ccccc2)CC1	10.1021/acs.jmedchem.9b00062
	72699817	115252	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	3	Agonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assay	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	CHEMBL3344458	115252	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	3	Agonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assay	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	44433303	145261	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS bindingAntagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	354	7	3	3	3.9	OC(CCNC12CC3CC(CC(C3)C1)C2)COc1cccc2[nH]ccc12	10.1016/j.bmcl.2007.07.086
	CHEMBL391230	145261	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS bindingAntagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	354	7	3	3	3.9	OC(CCNC12CC3CC(CC(C3)C1)C2)COc1cccc2[nH]ccc12	10.1016/j.bmcl.2007.07.086
	46180398	202714	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	291	0	0	2	3.8	C[C@@H]1Cc2ccc3c(c2O1)-c1cccc2c1[C@@H](C3)N(C)CC2	10.1021/jm9015763
	CHEMBL597094	202714	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	291	0	0	2	3.8	C[C@@H]1Cc2ccc3c(c2O1)-c1cccc2c1[C@@H](C3)N(C)CC2	10.1021/jm9015763
	42606457	17888	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	401	5	1	4	4.1	Cc1ccc(CNCC2(F)CCN(C(=O)c3scc4c3CCCC4)CC2)nc1	10.1021/jm100835q
	CHEMBL1259089	17888	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	401	5	1	4	4.1	Cc1ccc(CNCC2(F)CCN(C(=O)c3scc4c3CCCC4)CC2)nc1	10.1021/jm100835q
	172463952	196538	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	4	Partial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	418	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3	10.1021/acs.jmedchem.3c00098
	CHEMBL5426242	196538	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	4	Partial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	418	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3	10.1021/acs.jmedchem.3c00098
	71574302	86298	None	0	Human	Functional	pEC50	=	6.1	6.1	4	2	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	CHEMBL2312637	86298	None	0	Human	Functional	pEC50	=	6.1	6.1	4	2	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	492	8	1	5	4.4	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1	10.1016/j.ejmech.2012.11.042
	172463952	196538	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	4	Partial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	418	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3	10.1021/acs.jmedchem.3c00098
	CHEMBL5426242	196538	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	4	Partial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	418	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3	10.1021/acs.jmedchem.3c00098
	172450959	195711	None	0	Human	Functional	pEC50	=	7.1	7.1	-22	4	Partial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	420	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3	10.1021/acs.jmedchem.3c00098
	CHEMBL5409419	195711	None	0	Human	Functional	pEC50	=	7.1	7.1	-22	4	Partial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	420	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3	10.1021/acs.jmedchem.3c00098
	45483459	201301	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay	ChEMBL	271	3	1	2	4.1	Fc1cccc(C2CCNCC2)c1Oc1ccccc1	10.1016/j.bmcl.2009.10.014
	CHEMBL583751	201301	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Partial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assayPartial agonist activity at human 5HT1A expressed in HEK293 cells by FLIPR assay	ChEMBL	271	3	1	2	4.1	Fc1cccc(C2CCNCC2)c1Oc1ccccc1	10.1016/j.bmcl.2009.10.014
	5492087	208468	None	3	Rat	Functional	pEC50	=	6.1	6.1	-95	2	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	337	4	2	5	3.6	CN1CCC(c2c[nH]c3ccc(Nc4ncccc4[N+](=O)[O-])cc23)C1	10.1021/jm00042a003
	CHEMBL84942	208468	None	3	Rat	Functional	pEC50	=	6.1	6.1	-95	2	Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor	ChEMBL	337	4	2	5	3.6	CN1CCC(c2c[nH]c3ccc(Nc4ncccc4[N+](=O)[O-])cc23)C1	10.1021/jm00042a003
	44134038	202722	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at 5HT1A receptor by GTPgammaS assayAgonist activity at 5HT1A receptor by GTPgammaS assay	ChEMBL	306	3	1	3	4.1	Fc1cccc(Cl)c1Oc1ncccc1C1CCNCC1	10.1016/j.bmcl.2009.12.023
	CHEMBL597134	202722	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at 5HT1A receptor by GTPgammaS assayAgonist activity at 5HT1A receptor by GTPgammaS assay	ChEMBL	306	3	1	3	4.1	Fc1cccc(Cl)c1Oc1ncccc1C1CCNCC1	10.1016/j.bmcl.2009.12.023
	23625705	149789	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	423	6	1	5	3.1	CN(C)c1ccnc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)n1	10.1021/jm070714l
	CHEMBL394778	149789	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	423	6	1	5	3.1	CN(C)c1ccnc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)n1	10.1021/jm070714l
	172450959	195711	None	0	Human	Functional	pEC50	=	7.1	7.1	-22	4	Partial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	420	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3	10.1021/acs.jmedchem.3c00098
	CHEMBL5409419	195711	None	0	Human	Functional	pEC50	=	7.1	7.1	-22	4	Partial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T co-expressing G-alphai assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	420	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3	10.1021/acs.jmedchem.3c00098
	129186558	158638	None	0	Human	Functional	pEC50	=	6.1	6.1	-13	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	425	4	1	8	2.4	Cc1nc2n(c(=O)c1CCN1CCN(c3cncc4sccc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	CHEMBL4091554	158638	None	0	Human	Functional	pEC50	=	6.1	6.1	-13	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	425	4	1	8	2.4	Cc1nc2n(c(=O)c1CCN1CCN(c3cncc4sccc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	86280005	122298	None	0	Human	Functional	pEC50	=	8.1	8.1	1	3	Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	438	7	1	4	4.7	O=C(NCCCCN1CCN(c2cccc3ccccc23)CC1)c1cnc2ccccc2c1	10.1021/acs.jmedchem.5b00776
	CHEMBL3597635	122298	None	0	Human	Functional	pEC50	=	8.1	8.1	1	3	Agonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assayAgonist activity at 5HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay	ChEMBL	438	7	1	4	4.7	O=C(NCCCCN1CCN(c2cccc3ccccc23)CC1)c1cnc2ccccc2c1	10.1021/acs.jmedchem.5b00776
	CHEMBL5079986	217146	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		CCN1CCC(CCC(=O)c2ccc(N3CCN(CCCCc4c[nH]c5ccc(C#N)cc45)CC3)cc2)CC1	10.1016/j.ejmech.2021.114045
	46227770	202384	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	421	6	2	3	3.9	CCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NCC3	10.1016/j.bmcl.2009.10.134
	CHEMBL594788	202384	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	421	6	2	3	3.9	CCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NCC3	10.1016/j.bmcl.2009.10.134
	145964299	164227	None	0	Human	Functional	pEC50	=	8.1	8.1	1	6	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	426	8	1	6	3.8	CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4210030	164227	None	0	Human	Functional	pEC50	=	8.1	8.1	1	6	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	426	8	1	6	3.8	CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL5089691	217712	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(CC6CC6)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	132257275	180739	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	425	7	1	4	4.0	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCCOc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	CHEMBL4754941	180739	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	425	7	1	4	4.0	O=C(c1ccc(Cl)c(Cl)c1)N1CCC(F)(CNCCOc2ccccn2)CC1	10.1021/acs.jmedchem.9b00062
	156010883	177249	None	0	Human	Functional	pEC50	=	8.0	8.0	14	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	441	6	0	7	4.0	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2ccc(Cl)cn12	10.1016/j.bmcl.2020.127027
	CHEMBL4633978	177249	None	0	Human	Functional	pEC50	=	8.0	8.0	14	3	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	441	6	0	7	4.0	O=c1n(CCCCN2CCN(c3cccc4sccc34)CC2)nc2ccc(Cl)cn12	10.1016/j.bmcl.2020.127027
	156018685	177972	None	0	Human	Functional	pEC50	=	8.0	8.0	-1	6	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	432	6	0	8	3.2	N#Cc1ccc2nn(CCCCN3CCN(c4cccc5sccc45)CC3)c(=O)n2c1	10.1016/j.bmcl.2020.127027
	CHEMBL4644391	177972	None	0	Human	Functional	pEC50	=	8.0	8.0	-1	6	Agonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assayAgonist activity at 5HT1A receptor (unknown origin) by calcium-dye based FLIPR assay	ChEMBL	432	6	0	8	3.2	N#Cc1ccc2nn(CCCCN3CCN(c4cccc5sccc45)CC3)c(=O)n2c1	10.1016/j.bmcl.2020.127027
	91884611	159660	None	0	Human	Functional	pEC50	=	8.0	8.0	-3	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	424	4	1	7	3.0	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	CHEMBL4102670	159660	None	0	Human	Functional	pEC50	=	8.0	8.0	-3	6	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	424	4	1	7	3.0	Cc1nc2n(c(=O)c1CCN1CCN(c3cccc4sccc34)CC1)CCCC2O	10.1016/j.bmc.2017.07.040
	44408942	76762	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	353	6	2	3	3.7	CCN1CC(CNCCc2c[nH]c3ccc(F)cc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	CHEMBL206644	76762	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	353	6	2	3	3.7	CCN1CC(CNCCc2c[nH]c3ccc(F)cc23)Oc2ccccc21	10.1016/j.bmcl.2005.11.054
	145989181	167324	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	437	6	0	5	3.8	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2ccc3ccsc3c2)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4292250	167324	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	3	Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayAgonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay	ChEMBL	437	6	0	5	3.8	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2ccc3ccsc3c2)CC1	10.1016/j.ejmech.2017.12.099
	42606577	17869	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	381	5	1	5	2.8	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc4ccccn4n3)CC2)nc1	10.1021/jm100835q
	CHEMBL1259035	17869	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	381	5	1	5	2.8	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc4ccccn4n3)CC2)nc1	10.1021/jm100835q
	11430856	78050	None	28	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	450	10	2	5	3.0	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)c1	10.1021/jm070714l
	CHEMBL209821	78050	None	28	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	450	10	2	5	3.0	CC(=O)Nc1cccc(N2CCN(CCCCNS(=O)(=O)CC3CCCCC3)CC2)c1	10.1021/jm070714l
	145960544	161736	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	520	7	2	5	5.6	CC(=O)Nc1c2c(nc3cccc(N4CCN(CCCCc5c[nH]c6ccc(C#N)cc56)CC4)c13)CCCC2	10.1016/j.bmc.2018.04.037
	CHEMBL4130176	161736	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay	ChEMBL	520	7	2	5	5.6	CC(=O)Nc1c2c(nc3cccc(N4CCN(CCCCc5c[nH]c6ccc(C#N)cc56)CC4)c13)CCCC2	10.1016/j.bmc.2018.04.037
	44408890	140253	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	307	5	3	3	3.2	c1ccc2c(c1)NCC(CNCCc1c[nH]c3ccccc13)O2	10.1016/j.bmcl.2005.11.054
	CHEMBL380342	140253	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Intrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptorIntrinsic activity assessed by stimulation of [35S]GTP-gamma-S binding in CHO cells expressing 5HT1A receptor	ChEMBL	307	5	3	3	3.2	c1ccc2c(c1)NCC(CNCCc1c[nH]c3ccccc13)O2	10.1016/j.bmcl.2005.11.054
	132256728	180072	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	424	7	1	5	3.2	Cc1cnc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/acs.jmedchem.9b00062
	CHEMBL4746734	180072	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	424	7	1	5	3.2	Cc1cnc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/acs.jmedchem.9b00062
	10048222	54013	None	0	Human	Functional	pEC50	=	7.0	7.0	-33	2	Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1A receptor in HeLa cells; value ranges from 95-320Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1A receptor in HeLa cells; value ranges from 95-320	ChEMBL	428	6	2	4	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4cccc5ccccc45)CC3)cc12	10.1016/0960-894X(95)00091-7
	CHEMBL160581	54013	None	0	Human	Functional	pEC50	=	7.0	7.0	-33	2	Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1A receptor in HeLa cells; value ranges from 95-320Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1A receptor in HeLa cells; value ranges from 95-320	ChEMBL	428	6	2	4	3.6	NCCc1c[nH]c2ccc(OCC(=O)N3CCN(c4cccc5ccccc45)CC3)cc12	10.1016/0960-894X(95)00091-7
	164623991	185643	None	0	Human	Functional	pEC50	=	7.0	7.0	-15	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	410	10	2	4	4.2	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4862890	185643	None	0	Human	Functional	pEC50	=	7.0	7.0	-15	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	410	10	2	4	4.2	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	164623991	185643	None	0	Human	Functional	pEC50	=	7.0	7.0	-15	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	410	10	2	4	4.2	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4862890	185643	None	0	Human	Functional	pEC50	=	7.0	7.0	-15	3	Partial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at 5HT1A receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	410	10	2	4	4.2	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	127049848	140384	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	449	8	1	4	4.6	CNC(=O)c1cc(C)cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	CHEMBL3806047	140384	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	3	Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayAgonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay	ChEMBL	449	8	1	4	4.6	CNC(=O)c1cc(C)cc(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmcl.2016.04.087
	54296648	78799	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	312	8	2	2	3.9	Fc1ccc2[nH]cc(CCCNCCOc3ccccc3)c2c1	10.1021/jm0304010
	CHEMBL2112644	78799	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptor	ChEMBL	312	8	2	2	3.9	Fc1ccc2[nH]cc(CCCNCCOc3ccccc3)c2c1	10.1021/jm0304010
	5	139	None	45	Human	Functional	pEC50	=	7.0	7.0	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	5202	139	None	45	Human	Functional	pEC50	=	7.0	7.0	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.0	7.0	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	DB08839	139	None	45	Human	Functional	pEC50	=	7.0	7.0	-33	26	Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assayAgonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as increase in calcium mobilization measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2018.04.059
	42606334	17915	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	377	6	1	5	3.2	COc1cscc1C(=O)N1CCC(F)(CNCc2ccc(C)cn2)CC1	10.1021/jm100835q
	CHEMBL1259165	17915	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Intrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS bindingIntrinsic activity at human 5-HT1A receptor expressed in CHO cells assessed as increase of serotonin-induced [35S]GTPgammaS binding	ChEMBL	377	6	1	5	3.2	COc1cscc1C(=O)N1CCC(F)(CNCc2ccc(C)cn2)CC1	10.1021/jm100835q
	CHEMBL5093872	217941	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccccc6F)CC5)cc4)CC3)c2c1	10.1016/j.ejmech.2021.114045
	11774457	66809	None	0	Rat	Functional	pED50	=	8.3	8.3	-	1	Effective dose against 5-HT1a receptorEffective dose against 5-HT1a receptor	ChEMBL	419	8	3	4	2.5	NC(=O)c1ccc(N2CCN(CCCCc3c[nH]c4ccc(C(N)=O)cc34)CC2)cc1	10.1021/jm040792y
	CHEMBL185938	66809	None	0	Rat	Functional	pED50	=	8.3	8.3	-	1	Effective dose against 5-HT1a receptorEffective dose against 5-HT1a receptor	ChEMBL	419	8	3	4	2.5	NC(=O)c1ccc(N2CCN(CCCCc3c[nH]c4ccc(C(N)=O)cc34)CC2)cc1	10.1021/jm040792y
	4223	3992	None	57	Human	Functional	pIC50	=	9.7	9.7	7	17	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/acs.jmedchem.7b01788
	6918314	3992	None	57	Human	Functional	pIC50	=	9.7	9.7	7	17	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/acs.jmedchem.7b01788
	6918314.0	3992	None	57	Human	Functional	pIC50	=	9.7	9.7	7	17	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/acs.jmedchem.7b01788
	7427	3992	None	57	Human	Functional	pIC50	=	9.7	9.7	7	17	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/acs.jmedchem.7b01788
	CHEMBL439849	3992	None	57	Human	Functional	pIC50	=	9.7	9.7	7	17	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/acs.jmedchem.7b01788
	DB06684	3992	None	57	Human	Functional	pIC50	=	9.7	9.7	7	17	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	10.1021/acs.jmedchem.7b01788
	11249411	67416	None	0	Human	Functional	pIC50	=	9.2	9.2	1	3	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	402	6	1	5	3.9	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCO5)CC3)c2c1	10.1021/acs.jmedchem.7b01788
	CHEMBL188799	67416	None	0	Human	Functional	pIC50	=	9.2	9.2	1	3	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	402	6	1	5	3.9	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCO5)CC3)c2c1	10.1021/acs.jmedchem.7b01788
	11362047	67564	None	0	Human	Functional	pIC50	=	9	9.0	1	3	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	416	6	1	5	4.0	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c2c1	10.1021/acs.jmedchem.7b01788
	CHEMBL189709	67564	None	0	Human	Functional	pIC50	=	9	9.0	1	3	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	416	6	1	5	4.0	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c2c1	10.1021/acs.jmedchem.7b01788
	12004200	8572	None	0	Human	Functional	pIC50	=	8.9	8.9	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	467	4	0	6	4.9	COc1cc(N2CCN(C3CCN(c4cccc5c(C)ccnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1094558	8572	None	0	Human	Functional	pIC50	=	8.9	8.9	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	467	4	0	6	4.9	COc1cc(N2CCN(C3CCN(c4cccc5c(C)ccnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	12004226	8786	None	0	Human	Functional	pIC50	=	8	8.0	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	531	4	0	6	5.3	COc1cc(N2CCN(C3CCN(c4cc(Br)cc5cccnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1096529	8786	None	0	Human	Functional	pIC50	=	8	8.0	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	531	4	0	6	5.3	COc1cc(N2CCN(C3CCN(c4cc(Br)cc5cccnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	44593712	184949	None	0	Human	Functional	pIC50	=	6	6.0	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	446	7	2	4	4.1	N#Cc1ccc2[nH]cc(CCCN(C3CCC3)C3COc4c(F)ccc(C(N)=O)c4C3)c2c1	10.1021/jm8007097
	CHEMBL485228	184949	None	0	Human	Functional	pIC50	=	6	6.0	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	446	7	2	4	4.1	N#Cc1ccc2[nH]cc(CCCN(C3CCC3)C3COc4c(F)ccc(C(N)=O)c4C3)c2c1	10.1021/jm8007097
	44192200	197845	None	1	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	451	3	0	7	3.9	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(C#N)ccc4n2)CC1)O3	10.1021/jm900374r
	CHEMBL551964	197845	None	1	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	451	3	0	7	3.9	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(C#N)ccc4n2)CC1)O3	10.1021/jm900374r
	10111229	5070	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	394	5	1	4	4.2	Fc1ccc2[nH]cc(C3=CCN(CCOc4cccc5c4OCCO5)CC3)c2c1	10.1016/s0960-894x(01)00746-6
	CHEMBL105390	5070	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	394	5	1	4	4.2	Fc1ccc2[nH]cc(C3=CCN(CCOc4cccc5c4OCCO5)CC3)c2c1	10.1016/s0960-894x(01)00746-6
	11164569	118246	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	370	8	2	3	4.8	Fc1cc(OCCNCCCc2c[nH]c3ccc(F)cc23)c2occc2c1	10.1021/jm0304010
	CHEMBL340895	118246	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	370	8	2	3	4.8	Fc1cc(OCCNCCCc2c[nH]c3ccc(F)cc23)c2occc2c1	10.1021/jm0304010
	3251	4072	None	43	Human	Functional	pIC50	=	8.0	8.0	-3	4	Antagonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assayAntagonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/acs.jmedchem.8b01096
	5684	4072	None	43	Human	Functional	pIC50	=	8.0	8.0	-3	4	Antagonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assayAntagonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/acs.jmedchem.8b01096
	80	4072	None	43	Human	Functional	pIC50	=	8.0	8.0	-3	4	Antagonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assayAntagonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/acs.jmedchem.8b01096
	CHEMBL31354	4072	None	43	Human	Functional	pIC50	=	8.0	8.0	-3	4	Antagonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assayAntagonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/acs.jmedchem.8b01096
	9975609	164251	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Antagonism at the 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism at the 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	357	5	2	2	4.8	C1=C(c2c[nH]c3ccccc23)CCN(CCOc2cccc3[nH]ccc23)C1	10.1016/s0960-894x(01)00746-6
	CHEMBL421027	164251	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Antagonism at the 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism at the 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	357	5	2	2	4.8	C1=C(c2c[nH]c3ccccc23)CCN(CCOc2cccc3[nH]ccc23)C1	10.1016/s0960-894x(01)00746-6
	9929572	4811	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	376	5	1	4	4.1	C1=C(c2c[nH]c3ccccc23)CCN(CCOc2cccc3c2OCCO3)C1	10.1016/s0960-894x(01)00746-6
	CHEMBL104144	4811	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	376	5	1	4	4.1	C1=C(c2c[nH]c3ccccc23)CCN(CCOc2cccc3c2OCCO3)C1	10.1016/s0960-894x(01)00746-6
	44220114	197711	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	440	3	0	6	4.4	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4ccccc4n2)C[C@H]1C)O3	10.1021/jm900374r
	CHEMBL551107	197711	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	440	3	0	6	4.4	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4ccccc4n2)C[C@H]1C)O3	10.1021/jm900374r
	145946265	167612	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	396	10	0	4	3.9	Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4203310	167612	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	396	10	0	4	3.9	Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	CHEMBL4299892	167612	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	396	10	0	4	3.9	Cc1cc(C)c(OCCOCCN2CCN(CCc3ccccc3)CC2)c(C)c1	10.1016/j.bmcl.2018.04.059
	9820163	4841	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	358	5	2	3	4.2	C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3[nH]ccc23)C1	10.1016/s0960-894x(01)00746-6
	CHEMBL104229	4841	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	358	5	2	3	4.2	C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3[nH]ccc23)C1	10.1016/s0960-894x(01)00746-6
	10362715	16610	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	386	8	2	3	4.4	Fc1cc2c(c(OCCNCCCc3c[nH]c4ccc(F)cc34)c1)OCCC2	10.1021/jm0304010
	CHEMBL124069	16610	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	386	8	2	3	4.4	Fc1cc2c(c(OCCNCCCc3c[nH]c4ccc(F)cc34)c1)OCCC2	10.1021/jm0304010
	25139055	184488	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	455	7	2	3	4.9	NC(=O)c1ccc(Cl)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL484572	184488	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	455	7	2	3	4.9	NC(=O)c1ccc(Cl)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	11751072	78043	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	441	9	2	3	4.6	CCCN(CCCCc1c[nH]c2ccc(F)cc12)C1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm060218h
	CHEMBL209784	78043	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	441	9	2	3	4.6	CCCN(CCCCc1c[nH]c2ccc(F)cc12)C1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm060218h
	44365679	41198	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by forskolin stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by forskolin stimulated cAMP assay	ChEMBL	437	4	1	6	4.6	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1csc4ccccc14)C3)CO2	10.1016/j.bmcl.2003.10.024
	CHEMBL148860	41198	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by forskolin stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by forskolin stimulated cAMP assay	ChEMBL	437	4	1	6	4.6	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1csc4ccccc14)C3)CO2	10.1016/j.bmcl.2003.10.024
	11662592	72368	None	0	Human	Functional	pIC50	=	5.9	5.9	-15	2	Displacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptorDisplacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	CHEMBL198463	72368	None	0	Human	Functional	pIC50	=	5.9	5.9	-15	2	Displacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptorDisplacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5ccnc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	11845645	79554	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	413	7	2	3	3.8	CCN(CCCc1c[nH]c2ccc(F)cc12)[C@H]1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm060218h
	CHEMBL211393	79554	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	413	7	2	3	3.8	CCN(CCCc1c[nH]c2ccc(F)cc12)[C@H]1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm060218h
	9798864	168654	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	358	7	2	3	3.6	Fc1cc2c(c(OCCNCCc3c[nH]c4ccc(F)cc34)c1)OCC2	10.1021/jm0304010
	CHEMBL435612	168654	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	358	7	2	3	3.6	Fc1cc2c(c(OCCNCCc3c[nH]c4ccc(F)cc34)c1)OCC2	10.1021/jm0304010
	1220	187	None	44	Rat	Functional	pIC50	=	7.9	7.9	1	9	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
	31	187	None	44	Rat	Functional	pIC50	=	7.9	7.9	1	9	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
	7	187	None	44	Rat	Functional	pIC50	=	7.9	7.9	1	9	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
	CHEMBL56	187	None	44	Rat	Functional	pIC50	=	7.9	7.9	1	9	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
	9998826	120541	None	0	Rat	Functional	pIC50	=	7.9	7.9	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
	CHEMBL354210	120541	None	0	Rat	Functional	pIC50	=	7.9	7.9	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
	10474964	130539	None	0	Rat	Functional	pIC50	=	5.8	5.8	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL368061	130539	None	0	Rat	Functional	pIC50	=	5.8	5.8	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL5206021	130539	None	0	Rat	Functional	pIC50	=	5.8	5.8	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	44365728	120955	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assay	ChEMBL	382	4	1	6	2.7	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1ccccn1)C3)CO2	10.1016/j.bmcl.2003.10.024
	CHEMBL355953	120955	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assay	ChEMBL	382	4	1	6	2.7	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1ccccn1)C3)CO2	10.1016/j.bmcl.2003.10.024
	12004255	8961	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	539	4	0	6	5.7	COc1cc(N2CCN(C3CCN(c4ccc(F)c5cc(C(F)(F)F)cnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1098133	8961	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	539	4	0	6	5.7	COc1cc(N2CCN(C3CCN(c4ccc(F)c5cc(C(F)(F)F)cnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	10474964	130539	None	0	Rat	Functional	pIC50	=	7.8	7.8	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL368061	130539	None	0	Rat	Functional	pIC50	=	7.8	7.8	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL5206021	130539	None	0	Rat	Functional	pIC50	=	7.8	7.8	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	10046389	61436	None	0	Rat	Functional	pIC50	=	5.8	5.8	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
	CHEMBL177031	61436	None	0	Rat	Functional	pIC50	=	5.8	5.8	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
	44219922	197666	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	504	3	0	6	4.8	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(Br)ccc4n2)CC1)O3	10.1021/jm900374r
	CHEMBL550700	197666	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	504	3	0	6	4.8	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(Br)ccc4n2)CC1)O3	10.1021/jm900374r
	11303781	117337	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	388	8	2	4	3.8	Fc1cc(OCCNCCCc2c[nH]c3ccc(F)cc23)c2c(c1)OCCO2	10.1021/jm0304010
	CHEMBL339490	117337	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	388	8	2	4	3.8	Fc1cc(OCCNCCCc2c[nH]c3ccc(F)cc23)c2c(c1)OCCO2	10.1021/jm0304010
	10158434	26138	None	0	Rat	Functional	pIC50	=	7.8	7.8	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	409	5	2	4	4.8	OC(CCN1CCN(c2cccc3[nH]ccc23)CC1)c1csc2ccc(F)cc12	10.1021/jm0111200
	CHEMBL135623	26138	None	0	Rat	Functional	pIC50	=	7.8	7.8	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	409	5	2	4	4.8	OC(CCN1CCN(c2cccc3[nH]ccc23)CC1)c1csc2ccc(F)cc12	10.1021/jm0111200
	126	4070	None	6	Human	Functional	pIC50	=	7.8	7.8	1	2	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	395	6	1	4	3.5	COc1ccccc1N1CCN(CC1)C[C@@H](C(=O)NC(C)(C)C)c1ccccc1	10.1016/j.bmcl.2018.04.059
	6604840	4070	None	6	Human	Functional	pIC50	=	7.8	7.8	1	2	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	395	6	1	4	3.5	COc1ccccc1N1CCN(CC1)C[C@@H](C(=O)NC(C)(C)C)c1ccccc1	10.1016/j.bmcl.2018.04.059
	CHEMBL38288	4070	None	6	Human	Functional	pIC50	=	7.8	7.8	1	2	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	395	6	1	4	3.5	COc1ccccc1N1CCN(CC1)C[C@@H](C(=O)NC(C)(C)C)c1ccccc1	10.1016/j.bmcl.2018.04.059
	44219923	198436	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	469	4	1	7	3.2	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(C(N)=O)ccc4n2)CC1)O3	10.1021/jm900374r
	CHEMBL559778	198436	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	469	4	1	7	3.2	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(C(N)=O)ccc4n2)CC1)O3	10.1021/jm900374r
	44593715	185078	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	411	4	3	3	3.2	NC(=O)c1ccc(F)c2c1C[C@@H](NCC1CCc3[nH]c4ccc(F)cc4c3C1)CO2	10.1021/jm8007097
	CHEMBL485407	185078	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	411	4	3	3	3.2	NC(=O)c1ccc(F)c2c1C[C@@H](NCC1CCc3[nH]c4ccc(F)cc4c3C1)CO2	10.1021/jm8007097
	46180399	204655	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated [35S]GTPgamma binding	ChEMBL	291	0	0	2	3.8	C[C@H]1Cc2ccc3c(c2O1)-c1cccc2c1[C@@H](C3)N(C)CC2	10.1021/jm9015763
	CHEMBL609611	204655	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated [35S]GTPgamma binding	ChEMBL	291	0	0	2	3.8	C[C@H]1Cc2ccc3c(c2O1)-c1cccc2c1[C@@H](C3)N(C)CC2	10.1021/jm9015763
	9846057	165609	None	0	Rat	Functional	pIC50	=	7.7	7.7	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	403	5	1	5	4.7	OC(CCN1CCN(c2cccc3cccnc23)CC1)c1csc2ccccc12	10.1021/jm0111200
	CHEMBL424083	165609	None	0	Rat	Functional	pIC50	=	7.7	7.7	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	403	5	1	5	4.7	OC(CCN1CCN(c2cccc3cccnc23)CC1)c1csc2ccccc12	10.1021/jm0111200
	145961441	161456	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	502	8	0	6	5.6	CC(=O)c1c(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.ejmech.2017.05.047
	CHEMBL4126092	161456	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	502	8	0	6	5.6	CC(=O)c1c(OCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.ejmech.2017.05.047
	44220115	198476	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	465	3	0	7	4.3	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(C#N)ccc4n2)C[C@H]1C)O3	10.1021/jm900374r
	CHEMBL560170	198476	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	465	3	0	7	4.3	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(C#N)ccc4n2)C[C@H]1C)O3	10.1021/jm900374r
	44593716	185183	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	6	2	3	4.4	CCCN(CC1CCc2[nH]c3ccc(F)cc3c2C1)[C@H]1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm8007097
	CHEMBL485579	185183	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	6	2	3	4.4	CCCN(CC1CCc2[nH]c3ccc(F)cc3c2C1)[C@H]1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm8007097
	9842337	169515	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonism at the 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism at the 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	370	5	1	4	4.3	C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3ncccc23)C1	10.1016/s0960-894x(01)00746-6
	CHEMBL442391	169515	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonism at the 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism at the 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	370	5	1	4	4.3	C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3ncccc23)C1	10.1016/s0960-894x(01)00746-6
	25139058	184497	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	421	7	2	3	4.2	NC(=O)c1cccc2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL484580	184497	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	421	7	2	3	4.2	NC(=O)c1cccc2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL484747	184497	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	421	7	2	3	4.2	NC(=O)c1cccc2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	44220113	199211	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	440	3	0	6	4.4	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4ccccc4n2)C[C@@H]1C)O3	10.1021/jm900374r
	CHEMBL565234	199211	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	440	3	0	6	4.4	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4ccccc4n2)C[C@@H]1C)O3	10.1021/jm900374r
	145960744	161697	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	438	7	0	6	4.0	CC(=O)c1c(OCCCN2CCN(c3ccccc3F)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.ejmech.2017.05.047
	CHEMBL4129562	161697	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	438	7	0	6	4.0	CC(=O)c1c(OCCCN2CCN(c3ccccc3F)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.ejmech.2017.05.047
	44593712	184949	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	446	7	2	4	4.1	N#Cc1ccc2[nH]cc(CCCN(C3CCC3)C3COc4c(F)ccc(C(N)=O)c4C3)c2c1	10.1021/jm8007097
	CHEMBL485228	184949	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	446	7	2	4	4.1	N#Cc1ccc2[nH]cc(CCCN(C3CCC3)C3COc4c(F)ccc(C(N)=O)c4C3)c2c1	10.1021/jm8007097
	127034967	136575	None	0	Human	Functional	pIC50	=	5.7	5.7	-19	3	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay	ChEMBL	260	5	2	4	1.6	CB1C=Cc2c(cccc2OCC(O)CN(C)C)N1	10.1021/acs.jmedchem.5b01088
	CHEMBL3736156	136575	None	0	Human	Functional	pIC50	=	5.7	5.7	-19	3	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay	ChEMBL	260	5	2	4	1.6	CB1C=Cc2c(cccc2OCC(O)CN(C)C)N1	10.1021/acs.jmedchem.5b01088
	12004142	8773	None	1	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	471	4	0	6	4.7	COc1cc(N2CCN(C3CCN(c4ccc(F)c5cccnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1096476	8773	None	1	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	471	4	0	6	4.7	COc1cc(N2CCN(C3CCN(c4ccc(F)c5cccnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	12004223	8863	None	0	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	499	4	0	6	5.3	COc1cc(N2CCN(C3CCN(c4ccc(F)c5c(C)cc(C)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1097181	8863	None	0	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	499	4	0	6	5.3	COc1cc(N2CCN(C3CCN(c4ccc(F)c5c(C)cc(C)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	3251	4072	None	43	Human	Functional	pIC50	=	8.6	8.6	-3	4	Antagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5HT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5HT addition by calcium 4 dye based FLIPR assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2020.112709
	5684	4072	None	43	Human	Functional	pIC50	=	8.6	8.6	-3	4	Antagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5HT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5HT addition by calcium 4 dye based FLIPR assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2020.112709
	80	4072	None	43	Human	Functional	pIC50	=	8.6	8.6	-3	4	Antagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5HT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5HT addition by calcium 4 dye based FLIPR assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2020.112709
	CHEMBL31354	4072	None	43	Human	Functional	pIC50	=	8.6	8.6	-3	4	Antagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5HT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5HT addition by calcium 4 dye based FLIPR assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2020.112709
	12004280	8962	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	489	4	0	6	4.9	COc1cc(N2CCN(C3CCN(c4ccc(F)c5cc(F)cnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1098134	8962	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	489	4	0	6	4.9	COc1cc(N2CCN(C3CCN(c4ccc(F)c5cc(F)cnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	11293572	140206	None	3	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	439	7	2	3	4.3	NC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL380095	140206	None	3	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	439	7	2	3	4.3	NC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	46225309	202596	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	454	8	2	4	4.3	N#Cc1ccc2[nH]cc(CCCCN(CC3CC3)C3COc4ccc5c(c4C3)C(=O)NC5)c2c1	10.1016/j.bmcl.2009.10.134
	CHEMBL596297	202596	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	454	8	2	4	4.3	N#Cc1ccc2[nH]cc(CCCCN(CC3CC3)C3COc4ccc5c(c4C3)C(=O)NC5)c2c1	10.1016/j.bmcl.2009.10.134
	25139065	184480	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	9	1	4	4.5	NC(=O)c1ccc(F)c2c1CC(N(CCCCn1ccc3cccc(F)c31)CC1CC1)CO2	10.1021/jm8007097
	CHEMBL484537	184480	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	9	1	4	4.5	NC(=O)c1ccc(F)c2c1CC(N(CCCCn1ccc3cccc(F)c31)CC1CC1)CO2	10.1021/jm8007097
	44593714	185221	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	457	7	2	3	4.5	NC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3c(F)cc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL485625	185221	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	457	7	2	3	4.5	NC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3c(F)cc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	11484260	116985	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	328	8	2	3	3.5	COc1ccc(F)cc1OCCNCCc1c[nH]c2ccccc12	10.1021/jm0304010
	CHEMBL338482	116985	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	328	8	2	3	3.5	COc1ccc(F)cc1OCCNCCc1c[nH]c2ccccc12	10.1021/jm0304010
	44365671	38930	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by forskolin stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by forskolin stimulated cAMP assay	ChEMBL	431	4	1	5	4.5	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1ccc4ccccc4c1)C3)CO2	10.1016/j.bmcl.2003.10.024
	CHEMBL146751	38930	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by forskolin stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by forskolin stimulated cAMP assay	ChEMBL	431	4	1	5	4.5	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1ccc4ccccc4c1)C3)CO2	10.1016/j.bmcl.2003.10.024
	44365672	43961	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by forskolin stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by forskolin stimulated cAMP assay	ChEMBL	381	4	1	5	3.4	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1ccccc1)C3)CO2	10.1016/j.bmcl.2003.10.024
	CHEMBL151266	43961	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by forskolin stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by forskolin stimulated cAMP assay	ChEMBL	381	4	1	5	3.4	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1ccccc1)C3)CO2	10.1016/j.bmcl.2003.10.024
	9864676	127875	None	0	Rat	Functional	pIC50	=	6.7	6.7	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	380	6	0	3	4.5	O=C(CCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL366388	127875	None	0	Rat	Functional	pIC50	=	6.7	6.7	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	380	6	0	3	4.5	O=C(CCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	44219921	197593	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	444	3	0	6	4.2	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(F)ccc4n2)CC1)O3	10.1021/jm900374r
	CHEMBL550169	197593	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	444	3	0	6	4.2	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(F)ccc4n2)CC1)O3	10.1021/jm900374r
	9929572	4811	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	376	5	1	4	4.1	C1=C(c2c[nH]c3ccccc23)CCN(CCOc2cccc3c2OCCO3)C1	10.1016/s0960-894x(01)00746-6
	CHEMBL104144	4811	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	376	5	1	4	4.1	C1=C(c2c[nH]c3ccccc23)CCN(CCOc2cccc3c2OCCO3)C1	10.1016/s0960-894x(01)00746-6
	46225207	204358	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	433	7	2	3	4.2	O=C1NCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)CC1CC1)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL607419	204358	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	433	7	2	3	4.2	O=C1NCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)CC1CC1)CO3	10.1016/j.bmcl.2009.10.134
	11845636	79455	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	408	7	1	3	5.1	COc1cccc2c1C[C@@H](N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm060218h
	CHEMBL211363	79455	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	408	7	1	3	5.1	COc1cccc2c1C[C@@H](N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm060218h
	145963270	161673	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	464	9	0	7	4.3	COc1cccc(N2CCN(CCCCOc3ccc4c(C)cc(=O)oc4c3C(C)=O)CC2)c1	10.1016/j.ejmech.2017.05.047
	CHEMBL4129173	161673	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	464	9	0	7	4.3	COc1cccc(N2CCN(CCCCOc3ccc4c(C)cc(=O)oc4c3C(C)=O)CC2)c1	10.1016/j.ejmech.2017.05.047
	12004224	8790	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	521	4	0	6	5.6	COc1cc(N2CCN(C3CCN(c4cccc5ccc(C(F)(F)F)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1096540	8790	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	521	4	0	6	5.6	COc1cc(N2CCN(C3CCN(c4cccc5ccc(C(F)(F)F)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	11272673	69419	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	503	7	0	8	3.6	C[C@H](CN(C(=O)c1ccc([N+](=O)[O-])cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	CHEMBL193206	69419	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	503	7	0	8	3.6	C[C@H](CN(C(=O)c1ccc([N+](=O)[O-])cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	11339973	80241	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	453	8	2	3	4.7	NC(=O)c1ccc(F)c2c1CC(N(CCCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm060218h
	CHEMBL213673	80241	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	453	8	2	3	4.7	NC(=O)c1ccc(F)c2c1CC(N(CCCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm060218h
	164622805	185969	None	0	Human	Functional	pIC50	=	6.6	6.6	-21	6	Antagonist activity at 5-HT1A receptor (unknown origin)Antagonist activity at 5-HT1A receptor (unknown origin)	ChEMBL	467	9	0	6	4.5	Fc1ccc2c(C3CCN(CCCOc4ccc(CCN5CCOCC5)cc4)CC3)noc2c1	10.1016/j.bmcl.2021.127909
	CHEMBL4867978	185969	None	0	Human	Functional	pIC50	=	6.6	6.6	-21	6	Antagonist activity at 5-HT1A receptor (unknown origin)Antagonist activity at 5-HT1A receptor (unknown origin)	ChEMBL	467	9	0	6	4.5	Fc1ccc2c(C3CCN(CCCOc4ccc(CCN5CCOCC5)cc4)CC3)noc2c1	10.1016/j.bmcl.2021.127909
	44365672	43961	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assay	ChEMBL	381	4	1	5	3.4	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1ccccc1)C3)CO2	10.1016/j.bmcl.2003.10.024
	CHEMBL151266	43961	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assay	ChEMBL	381	4	1	5	3.4	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1ccccc1)C3)CO2	10.1016/j.bmcl.2003.10.024
	10116877	135279	None	7	Human	Functional	pIC50	=	7.6	7.6	-	1	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	483	6	0	7	3.6	C[C@H](CN(C(=O)c1ccc(C#N)cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	CHEMBL372205	135279	None	7	Human	Functional	pIC50	=	7.6	7.6	-	1	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	483	6	0	7	3.6	C[C@H](CN(C(=O)c1ccc(C#N)cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	25139217	185097	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	7	2	3	4.6	CNC(=O)c1ccc(F)c2c1C[C@@H](N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL485434	185097	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	7	2	3	4.6	CNC(=O)c1ccc(F)c2c1C[C@@H](N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	11845822	77599	None	5	Human	Functional	pIC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	439	7	2	3	4.3	NC(=O)c1ccc(F)c2c1C[C@@H](N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm060218h
	CHEMBL208773	77599	None	5	Human	Functional	pIC50	=	7.6	7.6	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	439	7	2	3	4.3	NC(=O)c1ccc(F)c2c1C[C@@H](N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm060218h
	145961730	161561	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	452	8	0	6	4.4	CC(=O)c1c(OCCCCN2CCN(c3ccccc3F)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.ejmech.2017.05.047
	CHEMBL4127564	161561	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	452	8	0	6	4.4	CC(=O)c1c(OCCCCN2CCN(c3ccccc3F)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.ejmech.2017.05.047
	145947560	167809	None	0	Human	Functional	pIC50	=	6.5	6.5	2	4	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	CHEMBL4212812	167809	None	0	Human	Functional	pIC50	=	6.5	6.5	2	4	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	CHEMBL4302457	167809	None	0	Human	Functional	pIC50	=	6.5	6.5	2	4	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	344	6	0	3	4.2	Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl	10.1016/j.bmcl.2018.04.059
	44219920	198116	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	471	4	0	8	4.0	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc([N+](=O)[O-])ccc4n2)CC1)O3	10.1021/jm900374r
	CHEMBL556474	198116	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	471	4	0	8	4.0	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc([N+](=O)[O-])ccc4n2)CC1)O3	10.1021/jm900374r
	11316467	122703	None	0	Human	Functional	pIC50	=	8.5	8.5	1	2	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	434	7	2	4	4.3	NC(=O)c1cc2cc(N3CCN(CCCCc4c[nH]c5ccc(F)cc45)CC3)ccc2o1	10.1021/acs.jmedchem.7b01788
	CHEMBL360390	122703	None	0	Human	Functional	pIC50	=	8.5	8.5	1	2	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	434	7	2	4	4.3	NC(=O)c1cc2cc(N3CCN(CCCCc4c[nH]c5ccc(F)cc45)CC3)ccc2o1	10.1021/acs.jmedchem.7b01788
	71449095	78823	None	0	Rat	Functional	pIC50	=	8.4	8.4	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	421	5	1	5	4.8	OC(CCN1CCN(c2ccc3ccccc3n2)CC1)c1csc2ccc(F)cc12	10.1021/jm0111200
	CHEMBL2112696	78823	None	0	Rat	Functional	pIC50	=	8.4	8.4	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	421	5	1	5	4.8	OC(CCN1CCN(c2ccc3ccccc3n2)CC1)c1csc2ccc(F)cc12	10.1021/jm0111200
	16091081	8606	None	0	Human	Functional	pIC50	=	8.4	8.4	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	453	4	0	6	4.6	COc1cc(N2CCN(C3CCN(c4cccc5cccnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1094872	8606	None	0	Human	Functional	pIC50	=	8.4	8.4	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	453	4	0	6	4.6	COc1cc(N2CCN(C3CCN(c4cccc5cccnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	12004116	8571	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	521	4	0	6	5.6	COc1cc(N2CCN(C3CCN(c4cccc5cc(C(F)(F)F)cnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1094557	8571	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	521	4	0	6	5.6	COc1cc(N2CCN(C3CCN(c4cccc5cc(C(F)(F)F)cnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	12004253	8744	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	551	5	0	7	5.6	COc1cc(N2CCN(C3CCN(c4cccc5c(OC)cc(C(F)(F)F)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1096156	8744	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	551	5	0	7	5.6	COc1cc(N2CCN(C3CCN(c4cccc5c(OC)cc(C(F)(F)F)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	10180988	116687	None	0	Rat	Functional	pIC50	=	7.5	7.5	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	428	5	1	6	4.1	OC(CCN1CCN(c2cccc3c2OCCO3)CC1)c1csc2ccc(F)cc12	10.1021/jm0111200
	CHEMBL336842	116687	None	0	Rat	Functional	pIC50	=	7.5	7.5	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	428	5	1	6	4.1	OC(CCN1CCN(c2cccc3c2OCCO3)CC1)c1csc2ccc(F)cc12	10.1021/jm0111200
	10159609	23646	None	0	Rat	Functional	pIC50	=	7.5	7.5	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	391	5	2	4	4.6	OC(CCN1CCN(c2cccc3[nH]ccc23)CC1)c1csc2ccccc12	10.1021/jm0111200
	CHEMBL133476	23646	None	0	Rat	Functional	pIC50	=	7.5	7.5	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	391	5	2	4	4.6	OC(CCN1CCN(c2cccc3[nH]ccc23)CC1)c1csc2ccccc12	10.1021/jm0111200
	44354158	21576	None	0	Rat	Functional	pIC50	=	7.5	7.5	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	405	5	2	5	4.4	OC(CCN1CCN(C2C=Cc3ccccc3N2)CC1)c1csc2ccccc12	10.1021/jm0111200
	CHEMBL131691	21576	None	0	Rat	Functional	pIC50	=	7.5	7.5	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	405	5	2	5	4.4	OC(CCN1CCN(C2C=Cc3ccccc3N2)CC1)c1csc2ccccc12	10.1021/jm0111200
	11568826	132866	None	0	Human	Functional	pIC50	=	6.5	6.5	-9	2	Displacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptorDisplacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	CHEMBL370110	132866	None	0	Human	Functional	pIC50	=	6.5	6.5	-9	2	Displacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptorDisplacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5cncc6ccccc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	11444410	168569	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	526	6	0	6	4.7	C[C@H](CN(C(=O)c1ccc(C(F)(F)F)cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	CHEMBL435111	168569	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	526	6	0	6	4.7	C[C@H](CN(C(=O)c1ccc(C(F)(F)F)cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	46225207	204358	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	433	7	2	3	4.2	O=C1NCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)CC1CC1)CO3	10.1016/j.bmcl.2009.10.134
	CHEMBL607419	204358	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	433	7	2	3	4.2	O=C1NCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)CC1CC1)CO3	10.1016/j.bmcl.2009.10.134
	46180192	204533	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated [35S]GTPgamma binding	ChEMBL	291	3	0	2	4.0	C=CCOc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm9015763
	CHEMBL608728	204533	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated [35S]GTPgamma binding	ChEMBL	291	3	0	2	4.0	C=CCOc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm9015763
	46180194	204620	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated [35S]GTPgamma binding	ChEMBL	291	0	0	2	3.8	CC1Cc2ccc3c(c2O1)-c1cccc2c1[C@@H](C3)N(C)CC2	10.1021/jm9015763
	CHEMBL609317	204620	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Agonist activity at 5HT1A receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated [35S]GTPgamma bindingAgonist activity at 5HT1A receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated [35S]GTPgamma binding	ChEMBL	291	0	0	2	3.8	CC1Cc2ccc3c(c2O1)-c1cccc2c1[C@@H](C3)N(C)CC2	10.1021/jm9015763
	9975609	164251	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	357	5	2	2	4.8	C1=C(c2c[nH]c3ccccc23)CCN(CCOc2cccc3[nH]ccc23)C1	10.1016/s0960-894x(01)00746-6
	CHEMBL421027	164251	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	357	5	2	2	4.8	C1=C(c2c[nH]c3ccccc23)CCN(CCOc2cccc3[nH]ccc23)C1	10.1016/s0960-894x(01)00746-6
	11261072	133642	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	492	6	0	6	4.4	C[C@H](CN(C(=O)c1ccc(Cl)cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	CHEMBL371149	133642	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	492	6	0	6	4.4	C[C@H](CN(C(=O)c1ccc(Cl)cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	12004114	8787	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	471	4	0	6	4.7	COc1cc(N2CCN(C3CCN(c4c(F)ccc5cccnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1096530	8787	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	471	4	0	6	4.7	COc1cc(N2CCN(C3CCN(c4c(F)ccc5cccnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	25140362	184328	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	8	2	3	4.6	CC(CCc1c[nH]c2ccc(F)cc12)N(CC1CC1)C1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm8007097
	CHEMBL483370	184328	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	8	2	3	4.6	CC(CCc1c[nH]c2ccc(F)cc12)N(CC1CC1)C1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm8007097
	44365679	41198	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assay	ChEMBL	437	4	1	6	4.6	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1csc4ccccc14)C3)CO2	10.1016/j.bmcl.2003.10.024
	CHEMBL148860	41198	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assay	ChEMBL	437	4	1	6	4.6	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1csc4ccccc14)C3)CO2	10.1016/j.bmcl.2003.10.024
	11394095	16814	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	354	7	2	3	3.8	Fc1cc2c(c(OCCNCCc3c[nH]c4ccccc34)c1)OCCC2	10.1021/jm0304010
	CHEMBL124638	16814	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorEffective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	354	7	2	3	3.8	Fc1cc2c(c(OCCNCCc3c[nH]c4ccccc34)c1)OCCC2	10.1021/jm0304010
	9998826	120541	None	0	Rat	Functional	pIC50	=	7.4	7.4	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
	CHEMBL354210	120541	None	0	Rat	Functional	pIC50	=	7.4	7.4	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
	11123104	165534	None	0	Rat	Functional	pIC50	=	6.4	6.4	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	442	5	1	6	4.4	OC(CCN1CCN(c2cccc3c2OCCCO3)CC1)c1csc2ccc(F)cc12	10.1021/jm0111200
	CHEMBL423896	165534	None	0	Rat	Functional	pIC50	=	6.4	6.4	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	442	5	1	6	4.4	OC(CCN1CCN(c2cccc3c2OCCCO3)CC1)c1csc2ccc(F)cc12	10.1021/jm0111200
	25139652	191693	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	9	1	4	4.5	NC(=O)c1ccc(F)c2c1CC(N(CCCCn1ccc3ccc(F)cc31)CC1CC1)CO2	10.1021/jm8007097
	CHEMBL519514	191693	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	9	1	4	4.5	NC(=O)c1ccc(F)c2c1CC(N(CCCCn1ccc3ccc(F)cc31)CC1CC1)CO2	10.1021/jm8007097
	145946714	167657	None	0	Human	Functional	pIC50	=	6.4	6.4	-4	4	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4213352	167657	None	0	Human	Functional	pIC50	=	6.4	6.4	-4	4	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300399	167657	None	0	Human	Functional	pIC50	=	6.4	6.4	-4	4	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1	10.1016/j.bmcl.2018.04.059
	145962266	161735	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	459	8	0	7	4.2	CC(=O)c1c(OCCCCN2CCN(c3ccccc3C#N)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.ejmech.2017.05.047
	CHEMBL4130132	161735	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	459	8	0	7	4.2	CC(=O)c1c(OCCCCN2CCN(c3ccccc3C#N)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.ejmech.2017.05.047
	10046389	61436	None	0	Rat	Functional	pIC50	=	7.4	7.4	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
	CHEMBL177031	61436	None	0	Rat	Functional	pIC50	=	7.4	7.4	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
	9820163	4841	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	358	5	2	3	4.2	C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3[nH]ccc23)C1	10.1016/s0960-894x(01)00746-6
	CHEMBL104229	4841	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	358	5	2	3	4.2	C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3[nH]ccc23)C1	10.1016/s0960-894x(01)00746-6
	11260140	185063	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	479	8	2	3	5.1	O=C(NC1CC1)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL485385	185063	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	479	8	2	3	5.1	O=C(NC1CC1)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	2303	3187	None	44	Human	Functional	pIC50	=	5.4	5.4	-346	20	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	4946	3187	None	44	Human	Functional	pIC50	=	5.4	5.4	-346	20	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	564	3187	None	44	Human	Functional	pIC50	=	5.4	5.4	-346	20	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	63	3187	None	44	Human	Functional	pIC50	=	5.4	5.4	-346	20	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	91536	3187	None	44	Human	Functional	pIC50	=	5.4	5.4	-346	20	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	CHEMBL27	3187	None	44	Human	Functional	pIC50	=	5.4	5.4	-346	20	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	CHEMBL452861	3187	None	44	Human	Functional	pIC50	=	5.4	5.4	-346	20	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	DB00571	3187	None	44	Human	Functional	pIC50	=	5.4	5.4	-346	20	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1021/acs.jmedchem.5b01088
	11293380	67415	None	0	Human	Functional	pIC50	=	8.4	8.4	1	2	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	395	6	1	4	4.2	Fc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCO5)CC3)c2c1	10.1021/acs.jmedchem.7b01788
	CHEMBL188798	67415	None	0	Human	Functional	pIC50	=	8.4	8.4	1	2	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	395	6	1	4	4.2	Fc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCO5)CC3)c2c1	10.1021/acs.jmedchem.7b01788
	3251	4072	None	43	Human	Functional	pIC50	=	8.4	8.4	-3	4	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm8007097
	5684	4072	None	43	Human	Functional	pIC50	=	8.4	8.4	-3	4	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm8007097
	80	4072	None	43	Human	Functional	pIC50	=	8.4	8.4	-3	4	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm8007097
	CHEMBL31354	4072	None	43	Human	Functional	pIC50	=	8.4	8.4	-3	4	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm8007097
	11261072	133642	None	0	Human	Functional	pIC50	=	8.4	8.4	-	1	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	492	6	0	6	4.4	C[C@H](CN(C(=O)c1ccc(Cl)cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	CHEMBL371149	133642	None	0	Human	Functional	pIC50	=	8.4	8.4	-	1	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	492	6	0	6	4.4	C[C@H](CN(C(=O)c1ccc(Cl)cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	11272673	69419	None	0	Human	Functional	pIC50	=	8.4	8.4	-	1	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	503	7	0	8	3.6	C[C@H](CN(C(=O)c1ccc([N+](=O)[O-])cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	CHEMBL193206	69419	None	0	Human	Functional	pIC50	=	8.4	8.4	-	1	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	503	7	0	8	3.6	C[C@H](CN(C(=O)c1ccc([N+](=O)[O-])cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	4431	2729	None	18	Human	Functional	pIC50	=	8.3	8.3	2884	2	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.bmcl.2018.04.059
	73	2729	None	18	Human	Functional	pIC50	=	8.3	8.3	2884	2	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.bmcl.2018.04.059
	CHEMBL8618	2729	None	18	Human	Functional	pIC50	=	8.3	8.3	2884	2	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.bmcl.2018.04.059
	12004201	8743	None	0	Human	Functional	pIC50	=	8.3	8.3	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	481	4	0	6	5.2	COc1cc(N2CCN(C3CCN(c4cccc5c(C)cc(C)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1096155	8743	None	0	Human	Functional	pIC50	=	8.3	8.3	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	481	4	0	6	5.2	COc1cc(N2CCN(C3CCN(c4cccc5c(C)cc(C)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	3251	4072	None	43	Human	Functional	pIC50	=	8.3	8.3	-3	4	Antagonist activity against human recombinant 5-HT1A receptor expressed in CHOK1 cells assessed as reduction in serotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting methodAntagonist activity against human recombinant 5-HT1A receptor expressed in CHOK1 cells assessed as reduction in serotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2014.12.045
	5684	4072	None	43	Human	Functional	pIC50	=	8.3	8.3	-3	4	Antagonist activity against human recombinant 5-HT1A receptor expressed in CHOK1 cells assessed as reduction in serotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting methodAntagonist activity against human recombinant 5-HT1A receptor expressed in CHOK1 cells assessed as reduction in serotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2014.12.045
	80	4072	None	43	Human	Functional	pIC50	=	8.3	8.3	-3	4	Antagonist activity against human recombinant 5-HT1A receptor expressed in CHOK1 cells assessed as reduction in serotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting methodAntagonist activity against human recombinant 5-HT1A receptor expressed in CHOK1 cells assessed as reduction in serotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2014.12.045
	CHEMBL31354	4072	None	43	Human	Functional	pIC50	=	8.3	8.3	-3	4	Antagonist activity against human recombinant 5-HT1A receptor expressed in CHOK1 cells assessed as reduction in serotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting methodAntagonist activity against human recombinant 5-HT1A receptor expressed in CHOK1 cells assessed as reduction in serotonin-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2014.12.045
	11248217	122769	None	0	Human	Functional	pIC50	=	7.4	7.4	1	2	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	425	6	1	4	4.7	Clc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c2c1	10.1021/acs.jmedchem.7b01788
	CHEMBL360407	122769	None	0	Human	Functional	pIC50	=	7.4	7.4	1	2	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	425	6	1	4	4.7	Clc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c2c1	10.1021/acs.jmedchem.7b01788
	11845815	166452	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	427	8	2	3	4.2	CCCN(CCCc1c[nH]c2ccc(F)cc12)[C@H]1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm8007097
	CHEMBL427411	166452	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	427	8	2	3	4.2	CCCN(CCCc1c[nH]c2ccc(F)cc12)[C@H]1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm8007097
	25139643	184498	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	451	8	2	4	4.2	COc1ccc2[nH]cc(CCCN(C3CCC3)C3COc4c(F)ccc(C(N)=O)c4C3)c2c1	10.1021/jm8007097
	CHEMBL484581	184498	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	451	8	2	4	4.2	COc1ccc2[nH]cc(CCCN(C3CCC3)C3COc4c(F)ccc(C(N)=O)c4C3)c2c1	10.1021/jm8007097
	10116877	135279	None	7	Human	Functional	pIC50	=	7.4	7.4	-	1	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	483	6	0	7	3.6	C[C@H](CN(C(=O)c1ccc(C#N)cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	CHEMBL372205	135279	None	7	Human	Functional	pIC50	=	7.4	7.4	-	1	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	483	6	0	7	3.6	C[C@H](CN(C(=O)c1ccc(C#N)cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	25140055	185073	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	8	1	4	4.7	NC(=O)c1ccc(F)c2c1CC(N(CCCCn1ccc3ccc(F)cc31)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL485398	185073	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	8	1	4	4.7	NC(=O)c1ccc(F)c2c1CC(N(CCCCn1ccc3ccc(F)cc31)C1CCC1)CO2	10.1021/jm8007097
	44593715	185078	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	411	4	3	3	3.2	NC(=O)c1ccc(F)c2c1C[C@@H](NCC1CCc3[nH]c4ccc(F)cc4c3C1)CO2	10.1021/jm8007097
	CHEMBL485407	185078	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	411	4	3	3	3.2	NC(=O)c1ccc(F)c2c1C[C@@H](NCC1CCc3[nH]c4ccc(F)cc4c3C1)CO2	10.1021/jm8007097
	86342156	149686	None	0	Human	Functional	pIC50	=	7.3	7.3	-33	4	Antagonistic activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induced calcium flux by Fluo-4 based FLIPR assayAntagonistic activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induced calcium flux by Fluo-4 based FLIPR assay	ChEMBL	438	6	1	6	4.4	O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1ccco1	10.1016/j.ejmech.2016.07.038
	CHEMBL3946995	149686	None	0	Human	Functional	pIC50	=	7.3	7.3	-33	4	Antagonistic activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induced calcium flux by Fluo-4 based FLIPR assayAntagonistic activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induced calcium flux by Fluo-4 based FLIPR assay	ChEMBL	438	6	1	6	4.4	O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1ccco1	10.1016/j.ejmech.2016.07.038
	12004227	8774	None	0	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	471	4	0	6	4.7	COc1cc(N2CCN(C3CCN(c4cc(F)cc5cccnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1096477	8774	None	0	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	471	4	0	6	4.7	COc1cc(N2CCN(C3CCN(c4cc(F)cc5cccnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	12004197	8819	None	1	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	467	4	0	6	4.9	COc1cc(N2CCN(C3CCN(c4cccc5ccc(C)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1096802	8819	None	1	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	467	4	0	6	4.9	COc1cc(N2CCN(C3CCN(c4cccc5ccc(C)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	11845822	77599	None	5	Human	Functional	pIC50	=	7.3	7.3	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	439	7	2	3	4.3	NC(=O)c1ccc(F)c2c1C[C@@H](N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL208773	77599	None	5	Human	Functional	pIC50	=	7.3	7.3	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	439	7	2	3	4.3	NC(=O)c1ccc(F)c2c1C[C@@H](N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	145963224	161593	None	0	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	450	8	0	7	3.9	COc1cccc(N2CCN(CCCOc3ccc4c(C)cc(=O)oc4c3C(C)=O)CC2)c1	10.1016/j.ejmech.2017.05.047
	CHEMBL4128053	161593	None	0	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	450	8	0	7	3.9	COc1cccc(N2CCN(CCCOc3ccc4c(C)cc(=O)oc4c3C(C)=O)CC2)c1	10.1016/j.ejmech.2017.05.047
	44220112	197651	None	0	Human	Functional	pIC50	=	5.3	5.3	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	426	3	0	6	4.1	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4ccccc4n2)CC1)O3	10.1021/jm900374r
	CHEMBL550576	197651	None	0	Human	Functional	pIC50	=	5.3	5.3	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	426	3	0	6	4.1	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4ccccc4n2)CC1)O3	10.1021/jm900374r
	11845636	79455	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	408	7	1	3	5.1	COc1cccc2c1C[C@@H](N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL211363	79455	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	408	7	1	3	5.1	COc1cccc2c1C[C@@H](N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	11751188	66966	None	0	Human	Functional	pIC50	=	8.3	8.3	1	3	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	409	6	1	4	4.2	Fc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c2c1	10.1021/acs.jmedchem.7b01788
	CHEMBL186655	66966	None	0	Human	Functional	pIC50	=	8.3	8.3	1	3	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	409	6	1	4	4.2	Fc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c2c1	10.1021/acs.jmedchem.7b01788
	4431	2729	None	18	Human	Functional	pIC50	=	8.3	8.3	2884	2	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2017.05.047
	73	2729	None	18	Human	Functional	pIC50	=	8.3	8.3	2884	2	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2017.05.047
	CHEMBL8618	2729	None	18	Human	Functional	pIC50	=	8.3	8.3	2884	2	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	393	7	0	5	2.9	COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2	10.1016/j.ejmech.2017.05.047
	46238348	9019	None	0	Human	Functional	pIC50	=	8.3	8.3	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	471	4	0	6	4.7	COc1cc(N2CCN(C3CCN(c4cccc5cc(F)cnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1098483	9019	None	0	Human	Functional	pIC50	=	8.3	8.3	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	471	4	0	6	4.7	COc1cc(N2CCN(C3CCN(c4cccc5cc(F)cnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	12004199	8570	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	467	4	0	6	4.9	COc1cc(N2CCN(C3CCN(c4cccc5cc(C)cnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1094556	8570	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	467	4	0	6	4.9	COc1cc(N2CCN(C3CCN(c4cccc5cc(C)cnc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	11374428	141736	None	0	Human	Functional	pIC50	=	7.3	7.3	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	453	9	2	3	4.6	NC(=O)c1ccc(F)c2c1CC(N(CCCCc1c[nH]c3ccc(F)cc13)CC1CC1)CO2	10.1021/jm060218h
	CHEMBL385353	141736	None	0	Human	Functional	pIC50	=	7.3	7.3	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	453	9	2	3	4.6	NC(=O)c1ccc(F)c2c1CC(N(CCCCc1c[nH]c3ccc(F)cc13)CC1CC1)CO2	10.1021/jm060218h
	11270594	192442	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	439	7	2	3	4.3	NC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3cc(F)ccc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL520661	192442	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	439	7	2	3	4.3	NC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3cc(F)ccc13)C1CCC1)CO2	10.1021/jm8007097
	2477	745	None	38	Rat	Functional	pIC50	=	7.3	7.3	1	20	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
	2477.0	745	None	38	Rat	Functional	pIC50	=	7.3	7.3	1	20	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
	36	745	None	38	Rat	Functional	pIC50	=	7.3	7.3	1	20	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
	437	745	None	38	Rat	Functional	pIC50	=	7.3	7.3	1	20	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
	CHEMBL49	745	None	38	Rat	Functional	pIC50	=	7.3	7.3	1	20	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
	DB00490	745	None	38	Rat	Functional	pIC50	=	7.3	7.3	1	20	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
	10474964	130539	None	0	Rat	Functional	pIC50	=	7.3	7.3	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL368061	130539	None	0	Rat	Functional	pIC50	=	7.3	7.3	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	CHEMBL5206021	130539	None	0	Rat	Functional	pIC50	=	7.3	7.3	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
	44335519	107564	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	369	5	1	3	4.9	C1=C(c2c[nH]c3ccccc23)CCN(CCOc2cccc3ncccc23)C1	10.1016/s0960-894x(01)00746-6
	CHEMBL318604	107564	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	369	5	1	3	4.9	C1=C(c2c[nH]c3ccccc23)CCN(CCOc2cccc3ncccc23)C1	10.1016/s0960-894x(01)00746-6
	25138913	192709	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	451	8	2	4	4.2	COc1cccc2c(CCCN(C3CCC3)C3COc4c(F)ccc(C(N)=O)c4C3)c[nH]c12	10.1021/jm8007097
	CHEMBL521510	192709	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	451	8	2	4	4.2	COc1cccc2c(CCCN(C3CCC3)C3COc4c(F)ccc(C(N)=O)c4C3)c[nH]c12	10.1021/jm8007097
	10319395	115514	None	0	Rat	Functional	pIC50	=	7.3	7.3	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	410	5	1	6	3.9	OC(CCN1CCN(c2cccc3c2OCCO3)CC1)c1csc2ccccc12	10.1021/jm0111200
	CHEMBL335082	115514	None	0	Rat	Functional	pIC50	=	7.3	7.3	-	1	Inhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranesInhibition of (+)-8-OH-DPAT stimulated [35S]GTP-gamma-S, binding to 5-hydroxytryptamine 1A receptor in hippocampal membranes	ChEMBL	410	5	1	6	3.9	OC(CCN1CCN(c2cccc3c2OCCO3)CC1)c1csc2ccccc12	10.1021/jm0111200
	9866320	198770	None	5	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	411	3	1	4	5.0	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CC=C(c2c[nH]c4ccccc24)CC1)O3	10.1021/jm900374r
	CHEMBL562248	198770	None	5	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	411	3	1	4	5.0	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CC=C(c2c[nH]c4ccccc24)CC1)O3	10.1021/jm900374r
	145947937	167825	None	0	Human	Functional	pIC50	=	7.3	7.3	1	4	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4207653	167825	None	0	Human	Functional	pIC50	=	7.3	7.3	1	4	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4302655	167825	None	0	Human	Functional	pIC50	=	7.3	7.3	1	4	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	398	9	0	5	3.8	COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	135339817	181590	None	0	Human	Functional	pIC50	=	7.3	7.3	-8	5	Antagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5HT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5HT addition by calcium 4 dye based FLIPR assay	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
	CHEMBL4764679	181590	None	0	Human	Functional	pIC50	=	7.3	7.3	-8	5	Antagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5HT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT1A receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5HT addition by calcium 4 dye based FLIPR assay	ChEMBL	437	6	0	5	4.2	CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O	10.1016/j.ejmech.2020.112709
	44220315	199067	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	465	3	0	7	4.3	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCCN(c2ccc4cc(C#N)ccc4n2)CC1)O3	10.1021/jm900374r
	CHEMBL564148	199067	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	465	3	0	7	4.3	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCCN(c2ccc4cc(C#N)ccc4n2)CC1)O3	10.1021/jm900374r
	129103318	167410	None	0	Human	Functional	pIC50	=	6.2	6.2	-64	6	Antagonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assayAntagonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	CHEMBL4293999	167410	None	0	Human	Functional	pIC50	=	6.2	6.2	-64	6	Antagonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assayAntagonist activity at serotonin 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	44220111	197710	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	510	4	0	7	5.0	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(OC(F)(F)F)ccc4n2)CC1)O3	10.1021/jm900374r
	CHEMBL551105	197710	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	510	4	0	7	5.0	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(OC(F)(F)F)ccc4n2)CC1)O3	10.1021/jm900374r
	145946733	167679	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	368	7	0	4	4.2	COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1	10.1016/j.bmcl.2018.04.059
	CHEMBL4205526	167679	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	368	7	0	4	4.2	COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300710	167679	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	368	7	0	4	4.2	COc1ccc(N2CCN(CCCOc3c(C)cc(C)cc3C)CC2)cc1	10.1016/j.bmcl.2018.04.059
	11444410	168569	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	526	6	0	6	4.7	C[C@H](CN(C(=O)c1ccc(C(F)(F)F)cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	CHEMBL435111	168569	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	526	6	0	6	4.7	C[C@H](CN(C(=O)c1ccc(C(F)(F)F)cc1)c1ccccn1)N1CCN(c2cccc3c2OCCO3)CC1	10.1021/jm049493z
	3251	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	Antagonist activity at 5-HT1A receptor (unknown origin) by calcium flux assayAntagonist activity at 5-HT1A receptor (unknown origin) by calcium flux assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/acs.jmedchem.3c00734
	5684	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	Antagonist activity at 5-HT1A receptor (unknown origin) by calcium flux assayAntagonist activity at 5-HT1A receptor (unknown origin) by calcium flux assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/acs.jmedchem.3c00734
	80	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	Antagonist activity at 5-HT1A receptor (unknown origin) by calcium flux assayAntagonist activity at 5-HT1A receptor (unknown origin) by calcium flux assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/acs.jmedchem.3c00734
	CHEMBL31354	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	Antagonist activity at 5-HT1A receptor (unknown origin) by calcium flux assayAntagonist activity at 5-HT1A receptor (unknown origin) by calcium flux assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/acs.jmedchem.3c00734
	11293572	140206	None	3	Human	Functional	pIC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	439	7	2	3	4.3	NC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm060218h
	CHEMBL380095	140206	None	3	Human	Functional	pIC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	439	7	2	3	4.3	NC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm060218h
	44593717	175094	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	465	6	2	3	4.4	NC(=O)c1ccc(F)c2c1C[C@@H](N(CC1CC1)CC1CCc3[nH]c4ccc(F)cc4c3C1)CO2	10.1021/jm8007097
	CHEMBL456657	175094	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	465	6	2	3	4.4	NC(=O)c1ccc(F)c2c1C[C@@H](N(CC1CC1)CC1CCc3[nH]c4ccc(F)cc4c3C1)CO2	10.1021/jm8007097
	25138907	175592	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	441	8	2	3	4.5	CCCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2c(F)ccc(C(=O)NC)c2C1	10.1021/jm8007097
	CHEMBL457750	175592	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	441	8	2	3	4.5	CCCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2c(F)ccc(C(=O)NC)c2C1	10.1021/jm8007097
	46225309	202596	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	454	8	2	4	4.3	N#Cc1ccc2[nH]cc(CCCCN(CC3CC3)C3COc4ccc5c(c4C3)C(=O)NC5)c2c1	10.1016/j.bmcl.2009.10.134
	CHEMBL596297	202596	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityAgonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activity	ChEMBL	454	8	2	4	4.3	N#Cc1ccc2[nH]cc(CCCCN(CC3CC3)C3COc4ccc5c(c4C3)C(=O)NC5)c2c1	10.1016/j.bmcl.2009.10.134
	25139058	184497	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	421	7	2	3	4.2	NC(=O)c1cccc2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL484580	184497	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	421	7	2	3	4.2	NC(=O)c1cccc2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL484747	184497	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	421	7	2	3	4.2	NC(=O)c1cccc2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	11845817	166383	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	439	8	2	3	4.2	NC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)CC1CC1)CO2	10.1021/jm060218h
	CHEMBL427051	166383	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	439	8	2	3	4.2	NC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)CC1CC1)CO2	10.1021/jm060218h
	11246169	116997	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	386	8	3	3	4.4	Fc1ccc2[nH]cc(CCCNCCOc3cc(Cl)cc4[nH]cnc34)c2c1	10.1021/jm0304010
	CHEMBL338520	116997	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	386	8	3	3	4.4	Fc1ccc2[nH]cc(CCCNCCOc3cc(Cl)cc4[nH]cnc34)c2c1	10.1021/jm0304010
	44335674	109776	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	396	5	1	4	4.3	Fc1ccc2c(C3CCN(CCOc4cccc5c4OCCO5)CC3)c[nH]c2c1	10.1016/s0960-894x(01)00746-6
	CHEMBL322915	109776	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	396	5	1	4	4.3	Fc1ccc2c(C3CCN(CCOc4cccc5c4OCCO5)CC3)c[nH]c2c1	10.1016/s0960-894x(01)00746-6
	11846005	78163	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	399	6	2	3	3.4	CCN(CCc1c[nH]c2ccc(F)cc12)C1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm060218h
	CHEMBL210348	78163	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	399	6	2	3	3.4	CCN(CCc1c[nH]c2ccc(F)cc12)C1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm060218h
	11177435	80227	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	413	7	2	3	3.8	CCCN(CCc1c[nH]c2ccc(F)cc12)C1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm060218h
	CHEMBL213639	80227	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	413	7	2	3	3.8	CCCN(CCc1c[nH]c2ccc(F)cc12)C1COc2c(F)ccc(C(N)=O)c2C1	10.1021/jm060218h
	10111229	5070	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	394	5	1	4	4.2	Fc1ccc2[nH]cc(C3=CCN(CCOc4cccc5c4OCCO5)CC3)c2c1	10.1016/s0960-894x(01)00746-6
	CHEMBL105390	5070	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,	ChEMBL	394	5	1	4	4.2	Fc1ccc2[nH]cc(C3=CCN(CCOc4cccc5c4OCCO5)CC3)c2c1	10.1016/s0960-894x(01)00746-6
	44335519	107564	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	369	5	1	3	4.9	C1=C(c2c[nH]c3ccccc23)CCN(CCOc2cccc3ncccc23)C1	10.1016/s0960-894x(01)00746-6
	CHEMBL318604	107564	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	369	5	1	3	4.9	C1=C(c2c[nH]c3ccccc23)CCN(CCOc2cccc3ncccc23)C1	10.1016/s0960-894x(01)00746-6
	12004254	8887	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	539	4	0	6	5.7	COc1cc(N2CCN(C3CCN(c4ccc(F)c5ccc(C(F)(F)F)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1097484	8887	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	539	4	0	6	5.7	COc1cc(N2CCN(C3CCN(c4ccc(F)c5ccc(C(F)(F)F)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	3251	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm060218h
	5684	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm060218h
	80	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm060218h
	CHEMBL31354	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm060218h
	3251	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1000908
	5684	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1000908
	80	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1000908
	CHEMBL31354	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm1000908
	3251	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm049493z
	5684	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm049493z
	80	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm049493z
	CHEMBL31354	4072	None	43	Human	Functional	pIC50	=	8.2	8.2	-3	4	In vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptorIn vitro antagonism of 8-OH-DPAT inhibition of forskolin-induced cAMP production in CHO cells expressing 5-HT1A receptor	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm049493z
	145946966	167697	None	0	Human	Functional	pIC50	=	8.1	8.1	2	3	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4209888	167697	None	0	Human	Functional	pIC50	=	8.1	8.1	2	3	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	CHEMBL4300899	167697	None	0	Human	Functional	pIC50	=	8.1	8.1	2	3	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells co-expressing Galpha16 assessed as decrease in serotonin calcium mobilization preincubated for 25 mins followed by serotonin challenge measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	354	7	0	4	3.9	COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1	10.1016/j.bmcl.2018.04.059
	11845819	78046	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	439	8	2	3	4.2	NC(=O)c1ccc(F)c2c1C[C@@H](N(CCCc1c[nH]c3ccc(F)cc13)CC1CC1)CO2	10.1021/jm060218h
	CHEMBL209802	78046	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	439	8	2	3	4.2	NC(=O)c1ccc(F)c2c1C[C@@H](N(CCCc1c[nH]c3ccc(F)cc13)CC1CC1)CO2	10.1021/jm060218h
	44220314	197735	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	440	3	0	6	4.4	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCCN(c2ccc4ccccc4n2)CC1)O3	10.1021/jm900374r
	CHEMBL551304	197735	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	440	3	0	6	4.4	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCCN(c2ccc4ccccc4n2)CC1)O3	10.1021/jm900374r
	44220316	197826	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	458	3	0	6	4.6	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCCN(c2ccc4cc(F)ccc4n2)CC1)O3	10.1021/jm900374r
	CHEMBL551909	197826	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	458	3	0	6	4.6	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCCN(c2ccc4cc(F)ccc4n2)CC1)O3	10.1021/jm900374r
	4106	2502	None	21	Human	Functional	pIC50	=	7.2	7.2	-186	7	Antagonistic activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induced calcium flux by Fluo-4 based FLIPR assayAntagonistic activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induced calcium flux by Fluo-4 based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.07.038
	5358812	2502	None	21	Human	Functional	pIC50	=	7.2	7.2	-186	7	Antagonistic activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induced calcium flux by Fluo-4 based FLIPR assayAntagonistic activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induced calcium flux by Fluo-4 based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.07.038
	89	2502	None	21	Human	Functional	pIC50	=	7.2	7.2	-186	7	Antagonistic activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induced calcium flux by Fluo-4 based FLIPR assayAntagonistic activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induced calcium flux by Fluo-4 based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.07.038
	CHEMBL93240	2502	None	21	Human	Functional	pIC50	=	7.2	7.2	-186	7	Antagonistic activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induced calcium flux by Fluo-4 based FLIPR assayAntagonistic activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induced calcium flux by Fluo-4 based FLIPR assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2016.07.038
	25138912	184350	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	455	7	2	3	4.9	NC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(Cl)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL483573	184350	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	455	7	2	3	4.9	NC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(Cl)cc13)C1CCC1)CO2	10.1021/jm8007097
	10046389	61436	None	0	Rat	Functional	pIC50	=	7.1	7.1	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
	CHEMBL177031	61436	None	0	Rat	Functional	pIC50	=	7.1	7.1	-	1	Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusInhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
	25139366	175594	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	441	8	2	3	4.5	CCCN(CCCc1c[nH]c2ccc(F)cc12)[C@H]1COc2c(F)ccc(C(=O)NC)c2C1	10.1021/jm8007097
	CHEMBL457751	175594	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	441	8	2	3	4.5	CCCN(CCCc1c[nH]c2ccc(F)cc12)[C@H]1COc2c(F)ccc(C(=O)NC)c2C1	10.1021/jm8007097
	44269674	39314	None	0	Rat	Functional	pIC50	=	6.1	6.1	-	1	In vitro Inhibitory activity tested at 5-hydroxytryptamine 1A receptor binding site in ratIn vitro Inhibitory activity tested at 5-hydroxytryptamine 1A receptor binding site in rat	ChEMBL	261	5	1	2	3.6	CCCN(CCC)[C@H]1Cc2c(O)cccc2C[C@H]1C	10.1021/jm00401a012
	CHEMBL14708	39314	None	0	Rat	Functional	pIC50	=	6.1	6.1	-	1	In vitro Inhibitory activity tested at 5-hydroxytryptamine 1A receptor binding site in ratIn vitro Inhibitory activity tested at 5-hydroxytryptamine 1A receptor binding site in rat	ChEMBL	261	5	1	2	3.6	CCCN(CCC)[C@H]1Cc2c(O)cccc2C[C@H]1C	10.1021/jm00401a012
	CHEMBL544668	39314	None	0	Rat	Functional	pIC50	=	6.1	6.1	-	1	In vitro Inhibitory activity tested at 5-hydroxytryptamine 1A receptor binding site in ratIn vitro Inhibitory activity tested at 5-hydroxytryptamine 1A receptor binding site in rat	ChEMBL	261	5	1	2	3.6	CCCN(CCC)[C@H]1Cc2c(O)cccc2C[C@H]1C	10.1021/jm00401a012
	9890484	198412	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	460	3	0	6	4.7	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(Cl)ccc4n2)CC1)O3	10.1021/jm900374r
	CHEMBL559579	198412	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	460	3	0	6	4.7	Cc1ccc2c3c(ccc2n1)OC[C@H](CN1CCN(c2ccc4cc(Cl)ccc4n2)CC1)O3	10.1021/jm900374r
	10090661	118232	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	372	7	2	3	4.0	Fc1cc2c(c(OCCNCCc3c[nH]c4ccc(F)cc34)c1)OCCC2	10.1021/jm0304010
	CHEMBL340873	118232	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Inhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptorInhibition concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing 5-hydroxytryptamine 1A receptor	ChEMBL	372	7	2	3	4.0	Fc1cc2c(c(OCCNCCc3c[nH]c4ccc(F)cc34)c1)OCCC2	10.1021/jm0304010
	11773729	125498	None	0	Human	Functional	pIC50	=	8.1	8.1	1	2	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	391	6	1	4	4.1	c1ccc2c(CCCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c[nH]c2c1	10.1021/acs.jmedchem.7b01788
	CHEMBL364610	125498	None	0	Human	Functional	pIC50	=	8.1	8.1	1	2	Agonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting methodAgonist activity at human 5HT1A expressed in CHO cell membranes assessed as increase in [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting method	ChEMBL	391	6	1	4	4.1	c1ccc2c(CCCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c[nH]c2c1	10.1021/acs.jmedchem.7b01788
	3251	4072	None	43	Human	Functional	pIC50	=	8.1	8.1	-3	4	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm049493z
	5684	4072	None	43	Human	Functional	pIC50	=	8.1	8.1	-3	4	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm049493z
	80	4072	None	43	Human	Functional	pIC50	=	8.1	8.1	-3	4	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm049493z
	CHEMBL31354	4072	None	43	Human	Functional	pIC50	=	8.1	8.1	-3	4	In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsIn vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cells	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1021/jm049493z
	11202474	184737	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	481	9	2	3	5.4	CCCNC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL484947	184737	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	481	9	2	3	5.4	CCCNC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	25140648	185095	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	7	2	3	4.6	CNC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL485433	185095	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	453	7	2	3	4.6	CNC(=O)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	12004141	8798	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	569	5	0	7	5.7	COc1cc(N2CCN(C3CCN(c4ccc(F)c5c(OC)cc(C(F)(F)F)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	CHEMBL1096671	8798	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	Antagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP levelAntagonist activity at human 5HT1A receptor expressed in CHO cells assessed as blockade of 8-OH-DPAT-induced inhibition of forskolin-stimulated increase in cAMP level	ChEMBL	569	5	0	7	5.7	COc1cc(N2CCN(C3CCN(c4ccc(F)c5c(OC)cc(C(F)(F)F)nc45)CC3)CC2)c2ncccc2c1	10.1021/jm1000908
	44365671	38930	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assay	ChEMBL	431	4	1	5	4.5	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1ccc4ccccc4c1)C3)CO2	10.1016/j.bmcl.2003.10.024
	CHEMBL146751	38930	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	Agonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assayAgonistic activity of compound towards 5-hydroxytryptamine 1A receptor was evaluated by [35S]GTP-gamma-S, stimulated cAMP assay	ChEMBL	431	4	1	5	4.5	COc1cccc2c1O[C@@H](CN1[C@H]3CC[C@@H]1C[C@@](O)(c1ccc4ccccc4c1)C3)CO2	10.1016/j.bmcl.2003.10.024
	9842337	169515	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	370	5	1	4	4.3	C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3ncccc23)C1	10.1016/s0960-894x(01)00746-6
	CHEMBL442391	169515	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	370	5	1	4	4.3	C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3ncccc23)C1	10.1016/s0960-894x(01)00746-6
	11477432	191803	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	493	8	2	3	5.5	O=C(NC1CCC1)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	CHEMBL519679	191803	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Activity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS bindingActivity at human cloned 5HT1A receptor expressed in CHO cells assessed as blockade of 5-HT-stimulated [35S]GTPgammaS binding	ChEMBL	493	8	2	3	5.5	O=C(NC1CCC1)c1ccc(F)c2c1CC(N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm8007097
	44335674	109776	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	396	5	1	4	4.3	Fc1ccc2c(C3CCN(CCOc4cccc5c4OCCO5)CC3)c[nH]c2c1	10.1016/s0960-894x(01)00746-6
	CHEMBL322915	109776	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonism of 5-hydroxytryptamine 1A receptor determined in vitroAntagonism of 5-hydroxytryptamine 1A receptor determined in vitro	ChEMBL	396	5	1	4	4.3	Fc1ccc2c(C3CCN(CCOc4cccc5c4OCCO5)CC3)c[nH]c2c1	10.1016/s0960-894x(01)00746-6
	11845824	77600	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	439	7	2	3	4.3	NC(=O)c1ccc(F)c2c1C[C@H](N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm060218h
	CHEMBL208774	77600	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	439	7	2	3	4.3	NC(=O)c1ccc(F)c2c1C[C@H](N(CCCc1c[nH]c3ccc(F)cc13)C1CCC1)CO2	10.1021/jm060218h
	9842682	107588	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonism at the 5-hydroxytryptamine 1A receptor in vitroAntagonism at the 5-hydroxytryptamine 1A receptor in vitro	ChEMBL	377	5	1	5	3.5	C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3c2OCCO3)C1	10.1016/s0960-894x(01)00746-6
	CHEMBL318738	107588	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonism at the 5-hydroxytryptamine 1A receptor in vitroAntagonism at the 5-hydroxytryptamine 1A receptor in vitro	ChEMBL	377	5	1	5	3.5	C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3c2OCCO3)C1	10.1016/s0960-894x(01)00746-6
	11418868	139441	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	425	7	2	3	3.8	NC(=O)c1ccc(F)c2c1CC(N(CCc1c[nH]c3ccc(F)cc13)CC1CC1)CO2	10.1021/jm060218h
	CHEMBL379298	139441	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Agonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP productionAgonist activity at human 5HT1A receptor expressed in CHO cells by inhibition of 8-OH-DPAT-induced decrease in forskolin-stimulated cAMP production	ChEMBL	425	7	2	3	3.8	NC(=O)c1ccc(F)c2c1CC(N(CCc1c[nH]c3ccc(F)cc13)CC1CC1)CO2	10.1021/jm060218h
	145961144	161678	None	0	Human	Functional	pIC50	=	7	7.0	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	445	7	0	7	3.8	CC(=O)c1c(OCCCN2CCN(c3ccccc3C#N)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.ejmech.2017.05.047
	CHEMBL4129293	161678	None	0	Human	Functional	pIC50	=	7	7.0	-	1	Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assayAntagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of serotonin-induced calcium mobilization preincubated for 25 mins followed by serotonin induction measured for 30 secs by aequorin-derived luminescence assay	ChEMBL	445	7	0	7	3.8	CC(=O)c1c(OCCCN2CCN(c3ccccc3C#N)CC2)ccc2c(C)cc(=O)oc12	10.1016/j.ejmech.2017.05.047
	10344103	105677	None	0	Rat	Functional	pKd	=	10.1	10.1	-	0	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)	ChEMBL	457	6	0	7	2.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	CHEMBL312339	105677	None	0	Rat	Functional	pKd	=	10.1	10.1	-	0	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)	ChEMBL	457	6	0	7	2.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	9848499	207758	None	22	Rat	Functional	pKd	=	10.1	10.1	-	0	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)	ChEMBL	491	6	0	7	2.9	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cc(Cl)cc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	CHEMBL79261	207758	None	22	Rat	Functional	pKd	=	10.1	10.1	-	0	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)	ChEMBL	491	6	0	7	2.9	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cc(Cl)cc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	11655728	16651	None	7	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	468	5	1	7	3.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241913	16651	None	7	Human	Functional	pKd	=	9.7	9.7	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	468	5	1	7	3.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	3251	4072	None	43	Rat	Functional	pKd	=	9.7	9.7	3	4	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes.Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes.	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/s0960-894x(98)00406-5
	5684	4072	None	43	Rat	Functional	pKd	=	9.7	9.7	3	4	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes.Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes.	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/s0960-894x(98)00406-5
	80	4072	None	43	Rat	Functional	pKd	=	9.7	9.7	3	4	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes.Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes.	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/s0960-894x(98)00406-5
	CHEMBL31354	4072	None	43	Rat	Functional	pKd	=	9.7	9.7	3	4	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes.Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes.	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/s0960-894x(98)00406-5
	9848499	207758	None	22	Rat	Functional	pKd	=	9.5	9.5	-	0	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 2)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 2)	ChEMBL	491	6	0	7	2.9	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cc(Cl)cc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	CHEMBL79261	207758	None	22	Rat	Functional	pKd	=	9.5	9.5	-	0	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 2)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 2)	ChEMBL	491	6	0	7	2.9	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cc(Cl)cc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	10344103	105677	None	0	Rat	Functional	pKd	=	9.4	9.4	-	0	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 2)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 2)	ChEMBL	457	6	0	7	2.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	CHEMBL312339	105677	None	0	Rat	Functional	pKd	=	9.4	9.4	-	0	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 2)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 2)	ChEMBL	457	6	0	7	2.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc3c2OCCO3)CC1	10.1016/s0960-894x(98)00406-5
	10405775	104964	None	0	Rat	Functional	pKd	=	7.8	7.8	-	1	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)	ChEMBL	352	6	0	4	3.6	c1ccc(CCCCN2CCN(c3cccc4c3OCCO4)CC2)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL311275	104964	None	0	Rat	Functional	pKd	=	7.8	7.8	-	1	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)	ChEMBL	352	6	0	4	3.6	c1ccc(CCCCN2CCN(c3cccc4c3OCCO4)CC2)cc1	10.1016/s0960-894x(98)00406-5
	CHEMBL543139	104964	None	0	Rat	Functional	pKd	=	7.8	7.8	-	1	Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)Compound was tested for its potency against 5-hydroxytryptamine 1A receptor in rat frontal cortex membranes (experiment 1)	ChEMBL	352	6	0	4	3.6	c1ccc(CCCCN2CCN(c3cccc4c3OCCO4)CC2)cc1	10.1016/s0960-894x(98)00406-5
	10020855	189379	None	0	Human	Functional	pKi	=	10.6	10.6	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysisAgonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysis	ChEMBL	351	4	0	4	3.9	COc1cccc([C@H]2CC[C@H](N3CCN(c4ccccn4)CC3)CC2)c1	10.1016/j.bmc.2015.05.042
	CHEMBL511857	189379	None	0	Human	Functional	pKi	=	10.6	10.6	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysisAgonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysis	ChEMBL	351	4	0	4	3.9	COc1cccc([C@H]2CC[C@H](N3CCN(c4ccccn4)CC3)CC2)c1	10.1016/j.bmc.2015.05.042
	9909089	187074	None	0	Human	Functional	pKi	=	10.2	10.2	-	1	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL490417	187074	None	0	Human	Functional	pKi	=	10.2	10.2	-	1	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1021/jm100482n
	9909089	187074	None	0	Human	Functional	pKi	=	10.2	10.2	-	1	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL490417	187074	None	0	Human	Functional	pKi	=	10.2	10.2	-	1	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	46900606	16632	None	0	Human	Functional	pKi	=	10.1	10.1	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	7	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C)nnn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241546	16632	None	0	Human	Functional	pKi	=	10.1	10.1	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	7	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C)nnn4-5)CC3)cccc2n1	10.1021/jm100482n
	46900459	16645	None	0	Human	Functional	pKi	=	10.1	10.1	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	7	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnc(C)n4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241738	16645	None	0	Human	Functional	pKi	=	10.1	10.1	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	440	4	0	7	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nnc(C)n4-5)CC3)cccc2n1	10.1021/jm100482n
	9979309	193091	None	0	Human	Functional	pKi	=	10.1	10.1	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL522257	193091	None	0	Human	Functional	pKi	=	10.1	10.1	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1021/jm100482n
	9979309	193091	None	0	Human	Functional	pKi	=	10.1	10.1	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL522257	193091	None	0	Human	Functional	pKi	=	10.1	10.1	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)N(C)C(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	18922713	98551	None	0	Rat	Functional	pKi	=	10.1	10.1	-	1	Inhibition constant of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorInhibition constant of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	10.1021/jm000339w
	CHEMBL276031	98551	None	0	Rat	Functional	pKi	=	10.1	10.1	-	1	Inhibition constant of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptorInhibition constant of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor	ChEMBL	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	10.1021/jm000339w
	44592250	178958	None	0	Human	Functional	pKi	=	10	10.0	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	442	5	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C4CC4)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL469568	178958	None	0	Human	Functional	pKi	=	10	10.0	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	442	5	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C4CC4)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	46900954	16659	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	508	6	1	7	3.9	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242081	16659	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	508	6	1	7	3.9	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	46899637	16667	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	522	7	1	7	4.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NCC6CC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242345	16667	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	522	7	1	7	4.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NCC6CC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	46899639	16676	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	522	5	0	7	4.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242533	16676	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	522	5	0	7	4.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	46900150	16703	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	425	4	0	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nccn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242904	16703	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	425	4	0	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nccn4-5)CC3)cccc2n1	10.1021/jm100482n
	44592209	179286	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	430	5	0	5	3.7	CCN1C(=O)COc2c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc21	10.1016/j.bmcl.2009.02.056
	CHEMBL472290	179286	None	0	Human	Functional	pKi	=	9.9	9.9	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	430	5	0	5	3.7	CCN1C(=O)COc2c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc21	10.1016/j.bmcl.2009.02.056
	46900455	16640	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	493	4	0	6	5.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C(F)(F)F)cn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241641	16640	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	493	4	0	6	5.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C(F)(F)F)cn4-5)CC3)cccc2n1	10.1021/jm100482n
	46900776	16646	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	496	5	0	7	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N(C)C)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241824	16646	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	496	5	0	7	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N(C)C)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	11712756	16650	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	482	5	1	7	3.3	CNC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	CHEMBL1241912	16650	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	482	5	1	7	3.3	CNC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	46900956	16661	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	522	6	1	7	4.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242167	16661	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	522	6	1	7	4.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	46899638	16671	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	508	5	0	7	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242436	16671	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	508	5	0	7	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	44138104	178938	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL469345	178938	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1021/jm100482n
	44138104	178938	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL469345	178938	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	44138104	178938	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL469345	178938	None	0	Human	Functional	pKi	=	9.8	9.8	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	416	4	0	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	10948133	165374	None	0	Human	Functional	pKi	=	9.8	9.8	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysisAgonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysis	ChEMBL	351	5	0	4	3.4	COc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)CC2	10.1016/j.bmc.2015.05.042
	CHEMBL423181	165374	None	0	Human	Functional	pKi	=	9.8	9.8	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysisAgonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysis	ChEMBL	351	5	0	4	3.4	COc1ccc2c(c1)CC(CCN1CCN(c3ccccn3)CC1)CC2	10.1016/j.bmc.2015.05.042
	46900451	16633	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	439	4	0	6	4.3	Cc1cn2c(n1)COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	CHEMBL1241547	16633	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	439	4	0	6	4.3	Cc1cn2c(n1)COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	46900453	16634	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	453	4	0	6	4.6	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C)c(C)n4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241548	16634	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	453	4	0	6	4.6	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4nc(C)c(C)n4-5)CC3)cccc2n1	10.1021/jm100482n
	46900457	16641	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	425	4	0	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4cncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241642	16641	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	425	4	0	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4cncn4-5)CC3)cccc2n1	10.1021/jm100482n
	46900782	16655	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	510	6	1	7	4.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC(C)C)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241998	16655	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	510	6	1	7	4.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC(C)C)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	44592296	178941	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	434	4	0	5	3.4	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL469374	178941	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	434	4	0	5	3.4	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1	10.1016/j.bmcl.2009.02.056
	44592297	189599	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	448	4	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL513875	189599	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	448	4	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1	10.1016/j.bmcl.2009.02.056
	9868889	72654	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Displacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptorDisplacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6cccnc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	CHEMBL199443	72654	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Displacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptorDisplacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6cccnc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	10787793	13400	None	0	Rat	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptorAntagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor	ChEMBL	411	6	1	4	3.5	COc1ccccc1N1CCN(C[C@@H](C)NC(=O)C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)CC1	10.1021/jm9806704
	CHEMBL1192653	13400	None	0	Rat	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptorAntagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor	ChEMBL	411	6	1	4	3.5	COc1ccccc1N1CCN(C[C@@H](C)NC(=O)C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)CC1	10.1021/jm9806704
	CHEMBL543932	13400	None	0	Rat	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptorAntagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor	ChEMBL	411	6	1	4	3.5	COc1ccccc1N1CCN(C[C@@H](C)NC(=O)C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)CC1	10.1021/jm9806704
	44364825	13837	None	0	Rat	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptorAntagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor	ChEMBL	383	6	1	4	2.8	COc1ccccc1N1CCN(CCNC(=O)C23CC4C[C@@H](C[C@H]2C4)C3)CC1	10.1021/jm9806704
	CHEMBL1195804	13837	None	0	Rat	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptorAntagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor	ChEMBL	383	6	1	4	2.8	COc1ccccc1N1CCN(CCNC(=O)C23CC4C[C@@H](C[C@H]2C4)C3)CC1	10.1021/jm9806704
	CHEMBL555379	13837	None	0	Rat	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptorAntagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor	ChEMBL	383	6	1	4	2.8	COc1ccccc1N1CCN(CCNC(=O)C23CC4C[C@@H](C[C@H]2C4)C3)CC1	10.1021/jm9806704
	46900958	16666	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	536	6	1	7	4.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242257	16666	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	536	6	1	7	4.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC6CCCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	44138098	189581	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL513715	189581	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1021/jm100482n
	44138098	189581	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL513715	189581	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	44592207	189472	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL512724	189472	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	44138098	189581	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL513715	189581	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5)CC3)cccc2n1	10.1016/j.bmcl.2009.02.056
	44405730	169022	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Displacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptorDisplacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccncc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	CHEMBL438619	169022	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Displacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptorDisplacement of [35S]GTP-gamma-S from human recombinant 5HT1A receptor	ChEMBL	460	4	0	8	2.8	CN1CCc2c(sc3ncn(CCN4CCN(c5cccc6ccncc56)CC4)c(=O)c23)C1	10.1016/j.bmcl.2005.04.077
	10248163	31571	None	0	Human	Functional	pKi	=	9.5	9.5	-288	3	Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysisAgonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysis	ChEMBL	363	5	0	4	4.0	COc1cccc2c1CCC/C2=C\CCN1CCN(c2ccccn2)CC1	10.1016/j.bmc.2015.05.042
	CHEMBL140406	31571	None	0	Human	Functional	pKi	=	9.5	9.5	-288	3	Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysisAgonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysis	ChEMBL	363	5	0	4	4.0	COc1cccc2c1CCC/C2=C\CCN1CCN(c2ccccn2)CC1	10.1016/j.bmc.2015.05.042
	46900612	16643	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	467	5	0	7	4.2	CC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	CHEMBL1241736	16643	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	467	5	0	7	4.2	CC(=O)c1ncn2c1COc1c(CCN3CCN(c4cccc5nc(C)ccc45)CC3)cccc1-2	10.1021/jm100482n
	11655728	16651	None	7	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	468	5	1	7	3.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1241913	16651	None	7	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	468	5	1	7	3.1	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(N)=O)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	44592294	189372	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	430	4	0	5	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1	10.1016/j.bmcl.2009.02.056
	CHEMBL511815	189372	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1A assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT	ChEMBL	430	4	0	5	3.7	Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1	10.1016/j.bmcl.2009.02.056
	11046644	30712	None	0	Human	Functional	pKi	=	9.4	9.4	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysisAgonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysis	ChEMBL	361	6	0	4	4.0	COc1cccc2c(CCCN3CCN(c4ccccn4)CC3)cccc12	10.1016/j.bmc.2015.05.042
	CHEMBL139505	30712	None	0	Human	Functional	pKi	=	9.4	9.4	-	1	Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysisAgonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by liquid scintillation counting analysis	ChEMBL	361	6	0	4	4.0	COc1cccc2c(CCCN3CCN(c4ccccn4)CC3)cccc12	10.1016/j.bmc.2015.05.042
	46899640	16683	None	0	Human	Functional	pKi	=	9.4	9.4	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	536	5	0	7	4.6	Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCCCC6)ncn4-5)CC3)cccc2n1	10.1021/jm100482n
	CHEMBL1242623	16683	None	0	Human	Functional	pKi	=	9.4	9.4	-	0	Antagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillati

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Main reference

Ligand source activities (1 row/activity)