GPCRdb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	134265828	181521	None	0	Human	Functional	pEC50	=	10.2	10.2	3162	2	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	231	2	1	3	1.8	CCCc1ccnc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	CHEMBL4765074	181521	None	0	Human	Functional	pEC50	=	10.2	10.2	3162	2	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	231	2	1	3	1.8	CCCc1ccnc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	5	139	None	72	Human	Functional	pEC50	=	10.1	10.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	5202	139	None	72	Human	Functional	pEC50	=	10.1	10.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	10.1	10.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	DB08839	139	None	72	Human	Functional	pEC50	=	10.1	10.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	5	139	None	72	Human	Functional	pEC50	=	10.1	10.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	5202	139	None	72	Human	Functional	pEC50	=	10.1	10.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	10.1	10.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	DB08839	139	None	72	Human	Functional	pEC50	=	10.1	10.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	46228438	199985	None	0	Human	Functional	pEC50	=	10	10.0	1862	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595195	199985	None	0	Human	Functional	pEC50	=	10	10.0	1862	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	11949712	202161	None	0	Human	Functional	pEC50	=	10	10.0	870	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL609306	202161	None	0	Human	Functional	pEC50	=	10	10.0	870	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	134265616	164411	None	0	Human	Functional	pEC50	=	10	10.0	1548	2	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1016/j.bmcl.2021.127872
	CHEMBL4213447	164411	None	0	Human	Functional	pEC50	=	10	10.0	1548	2	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1016/j.bmcl.2021.127872
	134265616	164411	None	0	Human	Functional	pEC50	=	10.0	10.0	1548	2	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4213447	164411	None	0	Human	Functional	pEC50	=	10.0	10.0	1548	2	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	134265620	164406	None	0	Human	Functional	pEC50	=	9.9	9.9	426	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	CHEMBL4213379	164406	None	0	Human	Functional	pEC50	=	9.9	9.9	426	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	134265620	164406	None	0	Human	Functional	pEC50	=	9.9	9.9	426	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1016/j.bmcl.2021.127872
	CHEMBL4213379	164406	None	0	Human	Functional	pEC50	=	9.9	9.9	426	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1016/j.bmcl.2021.127872
	5	139	None	72	Human	Functional	pEC50	=	9.9	9.9	-3	26	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	None	72	Human	Functional	pEC50	=	9.9	9.9	-3	26	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.9	9.9	-3	26	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	None	72	Human	Functional	pEC50	=	9.9	9.9	-3	26	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	None	72	Human	Functional	pEC50	=	9.9	9.9	-3	26	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	None	72	Human	Functional	pEC50	=	9.9	9.9	-3	26	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.9	9.9	-3	26	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	None	72	Human	Functional	pEC50	=	9.9	9.9	-3	26	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	None	72	Human	Functional	pEC50	=	9.8	9.8	-3	26	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	None	72	Human	Functional	pEC50	=	9.8	9.8	-3	26	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.8	9.8	-3	26	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	None	72	Human	Functional	pEC50	=	9.8	9.8	-3	26	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	None	72	Human	Functional	pEC50	=	9.8	9.8	-3	26	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	None	72	Human	Functional	pEC50	=	9.8	9.8	-3	26	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.8	9.8	-3	26	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	None	72	Human	Functional	pEC50	=	9.8	9.8	-3	26	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	None	72	Human	Functional	pEC50	=	9.8	9.8	-3	26	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.7b00584
	5202	139	None	72	Human	Functional	pEC50	=	9.8	9.8	-3	26	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.7b00584
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.8	9.8	-3	26	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.7b00584
	DB08839	139	None	72	Human	Functional	pEC50	=	9.8	9.8	-3	26	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.7b00584
	439280	120019	None	107	Human	Functional	pEC50	=	9.7	9.7	9	9	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	120019	None	107	Human	Functional	pEC50	=	9.7	9.7	9	9	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	120019	None	107	Human	Functional	pEC50	=	9.7	9.7	9	9	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	5	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.7b00584
	5202	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.7b00584
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.7b00584
	DB08839	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.7b00584
	134265627	164013	None	0	Human	Functional	pEC50	=	9.7	9.7	194	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	CHEMBL4208452	164013	None	0	Human	Functional	pEC50	=	9.7	9.7	194	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	5	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111626
	5202	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111626
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111626
	DB08839	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111626
	5	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111626
	5202	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111626
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111626
	DB08839	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2019.111626
	162643595	181688	None	0	Human	Functional	pEC50	=	9.7	9.7	501	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	230	2	1	2	2.4	CCCc1cccc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	CHEMBL4776557	181688	None	0	Human	Functional	pEC50	=	9.7	9.7	501	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	230	2	1	2	2.4	CCCc1cccc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	134147456	149633	None	0	Human	Functional	pEC50	=	9.7	9.7	999	3	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	230	2	1	2	2.4	CCCc1cccc2c1CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3947276	149633	None	0	Human	Functional	pEC50	=	9.7	9.7	999	3	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	230	2	1	2	2.4	CCCc1cccc2c1CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	16743289	59569	None	3	Human	Functional	pEC50	=	9.7	9.7	724	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line	ChEMBL	200	2	1	2	2.1	NCCc1cn2c3c(cccc13)CCC2	10.1016/s0960-894x(00)00141-4
	CHEMBL171774	59569	None	3	Human	Functional	pEC50	=	9.7	9.7	724	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line	ChEMBL	200	2	1	2	2.1	NCCc1cn2c3c(cccc13)CCC2	10.1016/s0960-894x(00)00141-4
	5	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	5202	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	DB08839	139	None	72	Human	Functional	pEC50	=	9.7	9.7	-3	26	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	439280	120019	None	107	Human	Functional	pEC50	=	9.7	9.7	9	9	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	120019	None	107	Human	Functional	pEC50	=	9.7	9.7	9	9	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	120019	None	107	Human	Functional	pEC50	=	9.7	9.7	9	9	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	10332474	59655	None	0	Human	Functional	pEC50	=	9.6	9.6	1513	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line	ChEMBL	252	2	1	3	2.9	NCCc1cn2c3c(cc(Cl)cc13)SCC2	10.1016/s0960-894x(00)00141-4
	CHEMBL172159	59655	None	0	Human	Functional	pEC50	=	9.6	9.6	1513	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line	ChEMBL	252	2	1	3	2.9	NCCc1cn2c3c(cc(Cl)cc13)SCC2	10.1016/s0960-894x(00)00141-4
	134152924	153510	None	0	Human	Functional	pEC50	=	9.5	9.5	251	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	248	2	1	3	2.5	CCSc1cccc2c1CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3979806	153510	None	0	Human	Functional	pEC50	=	9.5	9.5	251	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	248	2	1	3	2.5	CCSc1cccc2c1CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	5	139	None	72	Human	Functional	pEC50	=	9.5	9.5	-3	26	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	None	72	Human	Functional	pEC50	=	9.5	9.5	-3	26	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.5	9.5	-3	26	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	None	72	Human	Functional	pEC50	=	9.5	9.5	-3	26	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5	139	None	72	Human	Functional	pEC50	=	9.5	9.5	-3	26	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	None	72	Human	Functional	pEC50	=	9.5	9.5	-3	26	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.5	9.5	-3	26	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	None	72	Human	Functional	pEC50	=	9.5	9.5	-3	26	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	168280316	192863	None	0	Human	Functional	pEC50	=	9.5	9.5	41	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5187275	192863	None	0	Human	Functional	pEC50	=	9.5	9.5	41	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221883	192863	None	0	Human	Functional	pEC50	=	9.5	9.5	41	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	5	139	None	72	Human	Functional	pEC50	=	9.5	9.5	-3	26	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	None	72	Human	Functional	pEC50	=	9.5	9.5	-3	26	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.5	9.5	-3	26	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	None	72	Human	Functional	pEC50	=	9.5	9.5	-3	26	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	4106	2502	None	22	Human	Functional	pEC50	=	9.4	9.4	7	7	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2013.02.020
	5358812	2502	None	22	Human	Functional	pEC50	=	9.4	9.4	7	7	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2013.02.020
	89	2502	None	22	Human	Functional	pEC50	=	9.4	9.4	7	7	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2013.02.020
	CHEMBL93240	2502	None	22	Human	Functional	pEC50	=	9.4	9.4	7	7	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1016/j.ejmech.2013.02.020
	134265727	181785	None	0	Human	Functional	pEC50	=	9.4	9.4	794	2	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	245	2	1	3	2.0	CC(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	CHEMBL4777852	181785	None	0	Human	Functional	pEC50	=	9.4	9.4	794	2	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	245	2	1	3	2.0	CC(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	76333762	85306	None	0	Human	Functional	pEC50	=	9.4	9.4	-	1	Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as calcium mobilization by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as calcium mobilization by cell based assay	ChEMBL	248	0	1	2	3.6	Cc1c2n(c3c(C)c(Cl)ccc13)C(C)NCC2	10.1007/s00044-011-9615-3
	CHEMBL2260569	85306	None	0	Human	Functional	pEC50	=	9.4	9.4	-	1	Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as calcium mobilization by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as calcium mobilization by cell based assay	ChEMBL	248	0	1	2	3.6	Cc1c2n(c3c(C)c(Cl)ccc13)C(C)NCC2	10.1007/s00044-011-9615-3
	5	139	None	72	Human	Functional	pEC50	=	9.4	9.4	-3	26	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	None	72	Human	Functional	pEC50	=	9.4	9.4	-3	26	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.4	9.4	-3	26	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	None	72	Human	Functional	pEC50	=	9.4	9.4	-3	26	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5	139	None	72	Human	Functional	pEC50	=	9.4	9.4	-3	26	Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assayAgonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.9b01835
	5202	139	None	72	Human	Functional	pEC50	=	9.4	9.4	-3	26	Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assayAgonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.9b01835
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.4	9.4	-3	26	Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assayAgonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.9b01835
	DB08839	139	None	72	Human	Functional	pEC50	=	9.4	9.4	-3	26	Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assayAgonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.9b01835
	4376990	193009	None	5	Human	Functional	pEC50	=	9.3	9.3	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	193009	None	5	Human	Functional	pEC50	=	9.3	9.3	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	193009	None	5	Human	Functional	pEC50	=	9.3	9.3	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	4376990	193009	None	5	Human	Functional	pEC50	=	9.3	9.3	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	193009	None	5	Human	Functional	pEC50	=	9.3	9.3	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	193009	None	5	Human	Functional	pEC50	=	9.3	9.3	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	146025687	183715	None	0	Human	Functional	pEC50	=	9.2	9.2	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183715	None	0	Human	Functional	pEC50	=	9.2	9.2	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183715	None	0	Human	Functional	pEC50	=	9.2	9.2	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	146025687	183715	None	0	Human	Functional	pEC50	=	9.2	9.2	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183715	None	0	Human	Functional	pEC50	=	9.2	9.2	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183715	None	0	Human	Functional	pEC50	=	9.2	9.2	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	134265735	181849	None	0	Human	Functional	pEC50	=	9.2	9.2	-	1	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2cncc3c2CC[C@@H]2CNCCN32)cc1	10.1016/j.bmcl.2021.127872
	CHEMBL4778570	181849	None	0	Human	Functional	pEC50	=	9.2	9.2	-	1	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2cncc3c2CC[C@@H]2CNCCN32)cc1	10.1016/j.bmcl.2021.127872
	46933845	16162	None	0	Human	Functional	pEC50	=	9.1	9.1	18	2	Agonist activity at human 5HT2C receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor assessed as 5HT-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224034	16162	None	0	Human	Functional	pEC50	=	9.1	9.1	18	2	Agonist activity at human 5HT2C receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor assessed as 5HT-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	44572751	12499	None	1	Human	Functional	pEC50	=	9.1	9.1	16	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1186509	12499	None	1	Human	Functional	pEC50	=	9.1	9.1	16	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL467736	12499	None	1	Human	Functional	pEC50	=	9.1	9.1	16	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	168289382	191793	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	2	4	4	2.8	COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198213	191793	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	2	4	4	2.8	COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	134155852	151154	None	0	Human	Functional	pEC50	=	9.1	9.1	100	3	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	284	2	1	3	3.1	c1csc(Cc2cccc3c2CCC2CNCCN32)c1	10.1016/j.bmcl.2016.11.016
	CHEMBL3959570	151154	None	0	Human	Functional	pEC50	=	9.1	9.1	100	3	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	284	2	1	3	3.1	c1csc(Cc2cccc3c2CCC2CNCCN32)c1	10.1016/j.bmcl.2016.11.016
	18520432	152029	None	0	Human	Functional	pEC50	=	9.1	9.1	39	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	206	0	1	2	1.6	Fc1ccc2c(c1)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3967107	152029	None	0	Human	Functional	pEC50	=	9.1	9.1	39	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	206	0	1	2	1.6	Fc1ccc2c(c1)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	168289382	191793	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	2	4	4	2.8	COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198213	191793	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	2	4	4	2.8	COc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	5	139	None	72	Human	Functional	pEC50	=	9.1	9.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5202	139	None	72	Human	Functional	pEC50	=	9.1	9.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.1	9.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	DB08839	139	None	72	Human	Functional	pEC50	=	9.1	9.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5	139	None	72	Human	Functional	pEC50	=	9.1	9.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5202	139	None	72	Human	Functional	pEC50	=	9.1	9.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	9.1	9.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	DB08839	139	None	72	Human	Functional	pEC50	=	9.1	9.1	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	122442263	138357	None	0	Human	Functional	pEC50	=	9.0	9.0	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138357	None	0	Human	Functional	pEC50	=	9.0	9.0	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138357	None	0	Human	Functional	pEC50	=	9.0	9.0	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11949706	200055	None	0	Human	Functional	pEC50	=	9	9.0	1445	2	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	359	4	1	4	3.4	C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.10.112
	CHEMBL595645	200055	None	0	Human	Functional	pEC50	=	9	9.0	1445	2	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	359	4	1	4	3.4	C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.10.112
	11695000	89071	None	0	Human	Functional	pEC50	=	9	9.0	7	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	89071	None	0	Human	Functional	pEC50	=	9	9.0	7	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	89071	None	0	Human	Functional	pEC50	=	9	9.0	7	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	46884102	8062	None	1	Human	Functional	pEC50	=	9	9.0	128	2	Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor	ChEMBL	366	5	2	3	3.7	CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	CHEMBL1091106	8062	None	1	Human	Functional	pEC50	=	9	9.0	128	2	Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor	ChEMBL	366	5	2	3	3.7	CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	230	4119	None	25	Human	Functional	pEC50	=	9	9.0	3	3	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	3045225	4119	None	25	Human	Functional	pEC50	=	9	9.0	3	3	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	CHEMBL407909	4119	None	25	Human	Functional	pEC50	=	9	9.0	3	3	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	134143977	150753	None	0	Human	Functional	pEC50	=	9	9.0	100	3	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	296	2	1	2	3.1	Fc1ccc2c(c1Cc1ccccc1)CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3956394	150753	None	0	Human	Functional	pEC50	=	9	9.0	100	3	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	296	2	1	2	3.1	Fc1ccc2c(c1Cc1ccccc1)CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	168293874	192179	None	0	Human	Functional	pEC50	=	9.0	9.0	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192179	None	0	Human	Functional	pEC50	=	9.0	9.0	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168293874	192179	None	0	Human	Functional	pEC50	=	9.0	9.0	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192179	None	0	Human	Functional	pEC50	=	9.0	9.0	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	122442263	138357	None	0	Human	Functional	pEC50	=	9.0	9.0	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138357	None	0	Human	Functional	pEC50	=	9.0	9.0	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138357	None	0	Human	Functional	pEC50	=	9.0	9.0	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11514226	89110	None	0	Human	Functional	pEC50	=	9.0	9.0	85	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337494	89110	None	0	Human	Functional	pEC50	=	9.0	9.0	85	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365470	89110	None	0	Human	Functional	pEC50	=	9.0	9.0	85	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	134265663	163679	None	0	Human	Functional	pEC50	=	8.9	8.9	19	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4204710	163679	None	0	Human	Functional	pEC50	=	8.9	8.9	19	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	134265665	164799	None	0	Human	Functional	pEC50	=	8.9	8.9	1047	2	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	231	2	1	3	1.8	CCCc1cncc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4218374	164799	None	0	Human	Functional	pEC50	=	8.9	8.9	1047	2	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	231	2	1	3	1.8	CCCc1cncc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	146025687	183715	None	0	Human	Functional	pEC50	=	8.9	8.9	12	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183715	None	0	Human	Functional	pEC50	=	8.9	8.9	12	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183715	None	0	Human	Functional	pEC50	=	8.9	8.9	12	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	146025687	183715	None	0	Human	Functional	pEC50	=	8.9	8.9	12	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183715	None	0	Human	Functional	pEC50	=	8.9	8.9	12	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183715	None	0	Human	Functional	pEC50	=	8.9	8.9	12	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	134265732	163807	None	0	Human	Functional	pEC50	=	8.9	8.9	776	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	CHEMBL4206126	163807	None	0	Human	Functional	pEC50	=	8.9	8.9	776	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	134265665	164799	None	0	Human	Functional	pEC50	=	8.9	8.9	1047	2	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	231	2	1	3	1.8	CCCc1cncc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	CHEMBL4218374	164799	None	0	Human	Functional	pEC50	=	8.9	8.9	1047	2	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	231	2	1	3	1.8	CCCc1cncc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	16047544	12648	None	8	Human	Functional	pEC50	=	8.9	8.9	3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1187185	12648	None	8	Human	Functional	pEC50	=	8.9	8.9	3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL492916	12648	None	8	Human	Functional	pEC50	=	8.9	8.9	3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	134265732	163807	None	0	Human	Functional	pEC50	=	8.9	8.9	776	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4206126	163807	None	0	Human	Functional	pEC50	=	8.9	8.9	776	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	16115517	84838	None	0	Human	Functional	pEC50	=	8.9	8.9	5	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL223468	84838	None	0	Human	Functional	pEC50	=	8.9	8.9	5	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	11952353	199860	None	0	Human	Functional	pEC50	=	8.9	8.9	1071	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	CHEMBL594469	199860	None	0	Human	Functional	pEC50	=	8.9	8.9	1071	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	134139964	146152	None	0	Human	Functional	pEC50	=	8.8	8.8	79	3	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	278	2	1	2	3.0	c1ccc(Cc2cccc3c2CCC2CNCCN32)cc1	10.1016/j.bmcl.2016.11.016
	CHEMBL3919795	146152	None	0	Human	Functional	pEC50	=	8.8	8.8	79	3	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	278	2	1	2	3.0	c1ccc(Cc2cccc3c2CCC2CNCCN32)cc1	10.1016/j.bmcl.2016.11.016
	162652937	183662	None	0	Human	Functional	pEC50	=	8.8	8.8	22	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183662	None	0	Human	Functional	pEC50	=	8.8	8.8	22	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183662	None	0	Human	Functional	pEC50	=	8.8	8.8	22	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	162652937	183662	None	0	Human	Functional	pEC50	=	8.8	8.8	22	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183662	None	0	Human	Functional	pEC50	=	8.8	8.8	22	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183662	None	0	Human	Functional	pEC50	=	8.8	8.8	22	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	5	139	None	72	Human	Functional	pEC50	=	8.8	8.8	-3	26	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2012.01.122
	5202	139	None	72	Human	Functional	pEC50	=	8.8	8.8	-3	26	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2012.01.122
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	8.8	8.8	-3	26	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2012.01.122
	DB08839	139	None	72	Human	Functional	pEC50	=	8.8	8.8	-3	26	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2012.01.122
	5	139	None	72	Human	Functional	pEC50	=	8.8	8.8	-3	26	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	5202	139	None	72	Human	Functional	pEC50	=	8.8	8.8	-3	26	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	8.8	8.8	-3	26	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	DB08839	139	None	72	Human	Functional	pEC50	=	8.8	8.8	-3	26	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	152	364	None	29	Rat	Functional	pEC50	=	8.7	8.7	1	5	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	2107	364	None	29	Rat	Functional	pEC50	=	8.7	8.7	1	5	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	CHEMBL275854	364	None	29	Rat	Functional	pEC50	=	8.7	8.7	1	5	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	46230099	199312	None	0	Human	Functional	pEC50	=	8.7	8.7	25	3	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL590483	199312	None	0	Human	Functional	pEC50	=	8.7	8.7	25	3	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	11658860	2344	None	51	Human	Functional	pEC50	=	8.7	8.7	1	11	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2344	None	51	Human	Functional	pEC50	=	8.7	8.7	1	11	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2344	None	51	Human	Functional	pEC50	=	8.7	8.7	1	11	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.7	8.7	1	11	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.7	8.7	1	11	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	9901086	187631	None	33	Human	Functional	pEC50	=	8.7	8.7	54	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL494947	187631	None	33	Human	Functional	pEC50	=	8.7	8.7	54	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	168291775	191906	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5200026	191906	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	9901086	187631	None	33	Human	Functional	pEC50	=	8.7	8.7	54	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	CHEMBL494947	187631	None	33	Human	Functional	pEC50	=	8.7	8.7	54	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm301656h
	168291775	191906	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5200026	191906	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	314	1	4	3	3.5	Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	134265831	180018	None	0	Human	Functional	pEC50	=	8.7	8.7	19	2	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	203	0	1	3	1.1	Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	CHEMBL4747291	180018	None	0	Human	Functional	pEC50	=	8.7	8.7	19	2	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	203	0	1	3	1.1	Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	112713234	147450	None	1	Human	Functional	pEC50	=	8.7	8.7	15	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	202	0	1	2	1.7	Cc1cccc2c1CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3930174	147450	None	1	Human	Functional	pEC50	=	8.7	8.7	15	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	202	0	1	2	1.7	Cc1cccc2c1CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	16115271	79108	None	0	Human	Functional	pEC50	=	8	8.0	1	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL2113264	79108	None	0	Human	Functional	pEC50	=	8	8.0	1	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	46228437	199984	None	1	Human	Functional	pEC50	=	8	8.0	6	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595194	199984	None	1	Human	Functional	pEC50	=	8	8.0	6	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	24826868	91082	None	1	Human	Functional	pEC50	=	8	8.0	-1	3	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397877	91082	None	1	Human	Functional	pEC50	=	8	8.0	-1	3	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	162665030	183727	None	0	Human	Functional	pEC50	=	8	8.0	38	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4782824	183727	None	0	Human	Functional	pEC50	=	8	8.0	38	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803449	183727	None	0	Human	Functional	pEC50	=	8	8.0	38	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	44572800	12653	None	3	Human	Functional	pEC50	=	8	8.0	5	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL1187194	12653	None	3	Human	Functional	pEC50	=	8	8.0	5	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL493128	12653	None	3	Human	Functional	pEC50	=	8	8.0	5	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	23395431	94913	None	0	Human	Functional	pEC50	=	8	8.0	10	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254215	94913	None	0	Human	Functional	pEC50	=	8	8.0	10	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	10331841	169204	None	6	Human	Functional	pEC50	=	8	8.0	46	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	CHEMBL440752	169204	None	6	Human	Functional	pEC50	=	8	8.0	46	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	157292621	192971	None	0	Human	Functional	pEC50	=	8	8.0	5	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5199923	192971	None	0	Human	Functional	pEC50	=	8	8.0	5	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222513	192971	None	0	Human	Functional	pEC50	=	8	8.0	5	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	45485742	197823	None	0	Human	Functional	pEC50	=	8	8.0	18	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL572228	197823	None	0	Human	Functional	pEC50	=	8	8.0	18	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	90644511	111665	None	18	Human	Functional	pEC50	=	8	8.0	6	5	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	2	4	2.4	CNc1nc(Cc2ccccc2)nc2c1CCNC[C@@H]2C	10.1021/jm5003292
	CHEMBL3286556	111665	None	18	Human	Functional	pEC50	=	8	8.0	6	5	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	2	4	2.4	CNc1nc(Cc2ccccc2)nc2c1CCNC[C@@H]2C	10.1021/jm5003292
	134146228	149172	None	0	Human	Functional	pEC50	=	8	8.0	-	1	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	300	1	1	3	3.1	COc1cc2c(c(Cl)c1Cl)N1CCCNC[C@H]1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3943620	149172	None	0	Human	Functional	pEC50	=	8	8.0	-	1	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	300	1	1	3	3.1	COc1cc2c(c(Cl)c1Cl)N1CCCNC[C@H]1CC2	10.1016/j.bmcl.2016.11.016
	157292621	192971	None	0	Human	Functional	pEC50	=	8	8.0	5	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5199923	192971	None	0	Human	Functional	pEC50	=	8	8.0	5	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222513	192971	None	0	Human	Functional	pEC50	=	8	8.0	5	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	268	1	2	3	2.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	162665030	183727	None	0	Human	Functional	pEC50	=	8.0	8.0	38	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4782824	183727	None	0	Human	Functional	pEC50	=	8.0	8.0	38	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803449	183727	None	0	Human	Functional	pEC50	=	8.0	8.0	38	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	3.3	CCCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	25070582	61454	None	28	Dog	Functional	pEC50	=	8.0	8.0	2	9	Agonist activity at dog 5HT2C receptorAgonist activity at dog 5HT2C receptor	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770373	61454	None	28	Dog	Functional	pEC50	=	8.0	8.0	2	9	Agonist activity at dog 5HT2C receptorAgonist activity at dog 5HT2C receptor	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	146025684	183635	None	0	Human	Functional	pEC50	=	8.0	8.0	6	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183635	None	0	Human	Functional	pEC50	=	8.0	8.0	6	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183635	None	0	Human	Functional	pEC50	=	8.0	8.0	6	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	146025688	183694	None	0	Human	Functional	pEC50	=	8.0	8.0	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183694	None	0	Human	Functional	pEC50	=	8.0	8.0	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183694	None	0	Human	Functional	pEC50	=	8.0	8.0	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	134265705	164091	None	0	Human	Functional	pEC50	=	7	7.0	-1	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	CHEMBL4209572	164091	None	0	Human	Functional	pEC50	=	7	7.0	-1	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	162676809	183792	None	0	Human	Functional	pEC50	=	7	7.0	5	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4799299	183792	None	0	Human	Functional	pEC50	=	7	7.0	5	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804137	183792	None	0	Human	Functional	pEC50	=	7	7.0	5	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	25070581	61461	None	0	Human	Functional	pEC50	=	7	7.0	1	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770380	61461	None	0	Human	Functional	pEC50	=	7	7.0	1	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	71562661	87307	None	0	Human	Functional	pEC50	=	7	7.0	3	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	CHEMBL2331794	87307	None	0	Human	Functional	pEC50	=	7	7.0	3	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	134144277	150719	None	0	Human	Functional	pEC50	=	7	7.0	63	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	280	2	1	3	3.2	c1ccc(Oc2cccc3c2CCC2CNCCN32)cc1	10.1016/j.bmcl.2016.11.016
	CHEMBL3956136	150719	None	0	Human	Functional	pEC50	=	7	7.0	63	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	280	2	1	3	3.2	c1ccc(Oc2cccc3c2CCC2CNCCN32)cc1	10.1016/j.bmcl.2016.11.016
	19036360	107514	None	0	Rat	Functional	pEC50	=	7	7.0	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	270	3	1	3	3.2	COc1ccc2c(c1)-c1c(ccn1CC(C)N)C2(C)C	10.1021/jm970030l
	CHEMBL318639	107514	None	0	Rat	Functional	pEC50	=	7	7.0	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	270	3	1	3	3.2	COc1ccc2c(c1)-c1c(ccn1CC(C)N)C2(C)C	10.1021/jm970030l
	3288856	192813	None	2	Human	Functional	pEC50	=	6	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5176057	192813	None	2	Human	Functional	pEC50	=	6	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221496	192813	None	2	Human	Functional	pEC50	=	6	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	132820208	149658	None	0	Human	Functional	pEC50	=	6	6.0	-2	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	232	1	1	3	1.8	COc1cccc2c1CC[C@@H]1CNCCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3947432	149658	None	0	Human	Functional	pEC50	=	6	6.0	-2	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	232	1	1	3	1.8	COc1cccc2c1CC[C@@H]1CNCCCN21	10.1016/j.bmcl.2016.11.016
	10609802	107192	None	2	Rat	Functional	pEC50	=	6	6.0	-	1	Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	CHEMBL316527	107192	None	2	Rat	Functional	pEC50	=	6	6.0	-	1	Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	10560133	107337	None	0	Rat	Functional	pEC50	=	5	5.0	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	204	3	1	3	2.0	COc1ccc2c(ccn2CC(C)N)c1	10.1021/jm970030l
	CHEMBL317564	107337	None	0	Rat	Functional	pEC50	=	5	5.0	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	204	3	1	3	2.0	COc1ccc2c(ccn2CC(C)N)c1	10.1021/jm970030l
	3288856	192813	None	2	Human	Functional	pEC50	=	6	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5176057	192813	None	2	Human	Functional	pEC50	=	6	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221496	192813	None	2	Human	Functional	pEC50	=	6	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	1	3.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	162669817	183747	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@@H]3C[C@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4789175	183747	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@@H]3C[C@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803726	183747	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@@H]3C[C@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	45485787	197336	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	378	5	1	6	1.5	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1Br	10.1016/j.bmcl.2009.07.136
	CHEMBL568897	197336	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	378	5	1	6	1.5	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1Br	10.1016/j.bmcl.2009.07.136
	162669817	183747	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@@H]3C[C@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4789175	183747	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@@H]3C[C@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803726	183747	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@@H]3C[C@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	137631035	161147	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccccc1CNC[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4101194	161147	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccccc1CNC[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4117313	161147	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccccc1CNC[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	71562661	87307	None	0	Human	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	CHEMBL2331794	87307	None	0	Human	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	45484785	197760	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	328	6	1	6	1.4	Cc1cc(=O)n(CCCOc2ccccc2)c(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.133
	CHEMBL571733	197760	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	328	6	1	6	1.4	Cc1cc(=O)n(CCCOc2ccccc2)c(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.133
	118733766	120639	None	0	Human	Functional	pEC50	=	7.0	7.0	33	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416035	120639	None	0	Human	Functional	pEC50	=	7.0	7.0	33	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546870	120639	None	0	Human	Functional	pEC50	=	7.0	7.0	33	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	137631035	161147	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccccc1CNC[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4101194	161147	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccccc1CNC[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4117313	161147	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccccc1CNC[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	45484866	197253	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	366	5	1	6	2.0	CCn1c(COc2cc(F)ccc2Cl)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	CHEMBL568437	197253	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	366	5	1	6	2.0	CCn1c(COc2cc(F)ccc2Cl)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	11983273	77996	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209714	77996	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	137655846	158690	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	349	3	1	3	4.3	Cc1cc(-c2cccc3ccccc23)oc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4093102	158690	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	349	3	1	3	4.3	Cc1cc(-c2cccc3ccccc23)oc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	122461343	138362	None	0	Human	Functional	pEC50	=	7.0	7.0	9	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769704	138362	None	0	Human	Functional	pEC50	=	7.0	7.0	9	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771398	138362	None	0	Human	Functional	pEC50	=	7.0	7.0	9	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL4742882	214063	None	2	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802403	214063	None	2	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	122461343	138362	None	0	Human	Functional	pEC50	=	7.0	7.0	9	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769704	138362	None	0	Human	Functional	pEC50	=	7.0	7.0	9	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771398	138362	None	0	Human	Functional	pEC50	=	7.0	7.0	9	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	137635172	155823	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	337	2	1	4	3.3	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCNCC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4059943	155823	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	337	2	1	4	3.3	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCNCC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4742882	214063	None	2	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802403	214063	None	2	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	168290156	192965	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194324	192965	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222484	192965	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168277051	192837	None	0	Human	Functional	pEC50	=	6.0	6.0	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5178562	192837	None	0	Human	Functional	pEC50	=	6.0	6.0	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221669	192837	None	0	Human	Functional	pEC50	=	6.0	6.0	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	155553235	176549	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@@H]1C[C@@]1(F)c1cccc(Cl)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4544700	176549	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@@H]1C[C@@]1(F)c1cccc(Cl)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4597226	176549	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@@H]1C[C@@]1(F)c1cccc(Cl)c1	10.1016/j.ejmech.2019.111626
	11231392	84894	None	0	Human	Functional	pEC50	=	7.0	7.0	4	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL223628	84894	None	0	Human	Functional	pEC50	=	7.0	7.0	4	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	45484687	198464	None	0	Human	Functional	pEC50	=	7.0	7.0	1	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	339	3	1	5	1.9	O=c1cc2c(nn1Cc1ccccc1OC(F)(F)F)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL577410	198464	None	0	Human	Functional	pEC50	=	7.0	7.0	1	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	339	3	1	5	1.9	O=c1cc2c(nn1Cc1ccccc1OC(F)(F)F)CCNCC2	10.1016/j.bmcl.2009.07.063
	1534	103040	None	53	Human	Functional	pEC50	=	7.0	7.0	-5	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103040	None	53	Human	Functional	pEC50	=	7.0	7.0	-5	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103040	None	53	Human	Functional	pEC50	=	7.0	7.0	-5	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	1534	103040	None	53	Human	Functional	pEC50	=	7.0	7.0	-5	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103040	None	53	Human	Functional	pEC50	=	7.0	7.0	-5	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103040	None	53	Human	Functional	pEC50	=	7.0	7.0	-5	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	122461993	138359	None	0	Human	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769581	138359	None	0	Human	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771395	138359	None	0	Human	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168277051	192837	None	0	Human	Functional	pEC50	=	6.0	6.0	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5178562	192837	None	0	Human	Functional	pEC50	=	6.0	6.0	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221669	192837	None	0	Human	Functional	pEC50	=	6.0	6.0	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	362	2	2	2	5.2	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(Cl)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	168290156	192965	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194324	192965	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222484	192965	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	2	3.6	Fc1ncccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	155553235	176549	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@@H]1C[C@@]1(F)c1cccc(Cl)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4544700	176549	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@@H]1C[C@@]1(F)c1cccc(Cl)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4597226	176549	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@@H]1C[C@@]1(F)c1cccc(Cl)c1	10.1016/j.ejmech.2019.111626
	58911532	91104	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	244	2	1	2	1.6	CCCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397899	91104	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	244	2	1	2	1.6	CCCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	122461993	138359	None	0	Human	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769581	138359	None	0	Human	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771395	138359	None	0	Human	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	118733776	120651	None	0	Human	Functional	pEC50	=	6.0	6.0	2	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3416040	120651	None	0	Human	Functional	pEC50	=	6.0	6.0	2	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3546903	120651	None	0	Human	Functional	pEC50	=	6.0	6.0	2	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	16115652	83491	None	0	Human	Functional	pEC50	=	8.0	8.0	15	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL220211	83491	None	0	Human	Functional	pEC50	=	8.0	8.0	15	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	11630623	89099	None	0	Human	Functional	pEC50	=	8.0	8.0	151	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337499	89099	None	0	Human	Functional	pEC50	=	8.0	8.0	151	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365399	89099	None	0	Human	Functional	pEC50	=	8.0	8.0	151	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	118733818	120665	None	0	Human	Functional	pEC50	=	8.0	8.0	93	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416061	120665	None	0	Human	Functional	pEC50	=	8.0	8.0	93	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546956	120665	None	0	Human	Functional	pEC50	=	8.0	8.0	93	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	146025684	183635	None	0	Human	Functional	pEC50	=	8.0	8.0	6	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183635	None	0	Human	Functional	pEC50	=	8.0	8.0	6	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183635	None	0	Human	Functional	pEC50	=	8.0	8.0	6	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	146025688	183694	None	0	Human	Functional	pEC50	=	8.0	8.0	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183694	None	0	Human	Functional	pEC50	=	8.0	8.0	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183694	None	0	Human	Functional	pEC50	=	8.0	8.0	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	44572168	12484	None	1	Human	Functional	pEC50	=	8.0	8.0	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL1186458	12484	None	1	Human	Functional	pEC50	=	8.0	8.0	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL464475	12484	None	1	Human	Functional	pEC50	=	8.0	8.0	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	44626357	197552	None	0	Human	Functional	pEC50	=	8.0	8.0	1	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	382	5	1	6	2.1	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2C(F)(F)F)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL570274	197552	None	0	Human	Functional	pEC50	=	8.0	8.0	1	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	382	5	1	6	2.1	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2C(F)(F)F)n1	10.1016/j.bmcl.2009.07.136
	11658860	2344	None	51	Human	Functional	pEC50	=	8.0	8.0	1	11	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	2941	2344	None	51	Human	Functional	pEC50	=	8.0	8.0	1	11	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	4374	2344	None	51	Human	Functional	pEC50	=	8.0	8.0	1	11	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.0	8.0	1	11	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.0	8.0	1	11	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	10465263	64332	None	63	Human	Functional	pEC50	=	8.0	8.0	19	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181172	64332	None	63	Human	Functional	pEC50	=	8.0	8.0	19	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	10036629	64637	None	0	Human	Functional	pEC50	=	8.0	8.0	7	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL181787	64637	None	0	Human	Functional	pEC50	=	8.0	8.0	7	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	9994008	166149	None	0	Human	Functional	pEC50	=	8.0	8.0	3	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL426235	166149	None	0	Human	Functional	pEC50	=	8.0	8.0	3	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	44414290	78427	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Inhibition of 5HT2C assessed as intracellular calcium concentrationInhibition of 5HT2C assessed as intracellular calcium concentration	ChEMBL	193	0	1	1	2.2	Clc1ccc2c(c1)C[C@@H]1CNC[C@H]21	10.1016/j.bmcl.2006.04.070
	CHEMBL211153	78427	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Inhibition of 5HT2C assessed as intracellular calcium concentrationInhibition of 5HT2C assessed as intracellular calcium concentration	ChEMBL	193	0	1	1	2.2	Clc1ccc2c(c1)C[C@@H]1CNC[C@H]21	10.1016/j.bmcl.2006.04.070
	54584720	61455	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	3	1	3	2.0	c1ccc(CCc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770374	61455	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	3	1	3	2.0	c1ccc(CCc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	46230094	199311	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2ccc(Cl)cc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590482	199311	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2ccc(Cl)cc21	10.1016/j.bmcl.2009.12.014
	155512645	169683	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.3	CC(c1ccccc1)c1cc2c(nn1)CCNCC2	10.1016/j.bmcl.2016.06.060
	CHEMBL4437696	169683	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.3	CC(c1ccccc1)c1cc2c(nn1)CCNCC2	10.1016/j.bmcl.2016.06.060
	45484865	198331	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	339	5	1	7	1.1	CCn1c(COc2cccc(C#N)c2)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	CHEMBL576253	198331	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	339	5	1	7	1.1	CCn1c(COc2cccc(C#N)c2)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	59312249	111672	None	0	Human	Functional	pEC50	=	7.0	7.0	8	2	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	2	4	2.4	CNc1nc(C(C)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	CHEMBL3286565	111672	None	0	Human	Functional	pEC50	=	7.0	7.0	8	2	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	2	4	2.4	CNc1nc(C(C)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	162652562	183657	None	0	Human	Functional	pEC50	=	7.0	7.0	4	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4752604	183657	None	0	Human	Functional	pEC50	=	7.0	7.0	4	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4802785	183657	None	0	Human	Functional	pEC50	=	7.0	7.0	4	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	168292007	192988	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5200288	192988	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222607	192988	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	118733804	120654	None	0	Human	Functional	pEC50	=	6.0	6.0	4	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416054	120654	None	0	Human	Functional	pEC50	=	6.0	6.0	4	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546906	120654	None	0	Human	Functional	pEC50	=	6.0	6.0	4	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	162652562	183657	None	0	Human	Functional	pEC50	=	7.0	7.0	4	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4752604	183657	None	0	Human	Functional	pEC50	=	7.0	7.0	4	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4802785	183657	None	0	Human	Functional	pEC50	=	7.0	7.0	4	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	168292007	192988	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5200288	192988	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222607	192988	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	45485764	197828	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	325	5	1	7	0.6	N#Cc1ccccc1OCCn1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	CHEMBL572253	197828	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	325	5	1	7	0.6	N#Cc1ccccc1OCCn1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	162659576	183697	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762960	183697	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803163	183697	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	122442272	138348	None	0	Human	Functional	pEC50	=	6.9	6.9	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138348	None	0	Human	Functional	pEC50	=	6.9	6.9	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138348	None	0	Human	Functional	pEC50	=	6.9	6.9	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442268	138353	None	0	Human	Functional	pEC50	=	6.9	6.9	7	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769633	138353	None	0	Human	Functional	pEC50	=	6.9	6.9	7	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771389	138353	None	0	Human	Functional	pEC50	=	6.9	6.9	7	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	162659576	183697	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762960	183697	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803163	183697	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	44573226	193173	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	404	4	1	4	2.7	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2ccccc2F)CC1	10.1016/j.bmcl.2009.02.071
	CHEMBL523169	193173	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	404	4	1	4	2.7	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2ccccc2F)CC1	10.1016/j.bmcl.2009.02.071
	122442272	138348	None	0	Human	Functional	pEC50	=	6.9	6.9	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138348	None	0	Human	Functional	pEC50	=	6.9	6.9	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138348	None	0	Human	Functional	pEC50	=	6.9	6.9	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442268	138353	None	0	Human	Functional	pEC50	=	6.9	6.9	7	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769633	138353	None	0	Human	Functional	pEC50	=	6.9	6.9	7	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771389	138353	None	0	Human	Functional	pEC50	=	6.9	6.9	7	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	3549735	192207	None	2	Human	Functional	pEC50	=	5.9	5.9	6	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5204651	192207	None	2	Human	Functional	pEC50	=	5.9	5.9	6	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	3549735	192207	None	2	Human	Functional	pEC50	=	5.9	5.9	6	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5204651	192207	None	2	Human	Functional	pEC50	=	5.9	5.9	6	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	300	1	2	1	4.2	Fc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	44572308	12558	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	252	5	2	2	3.4	NC[C@H]1C[C@@H]1c1cccc(NCc2ccccc2)c1	10.1021/jm801354e
	CHEMBL1186720	12558	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	252	5	2	2	3.4	NC[C@H]1C[C@@H]1c1cccc(NCc2ccccc2)c1	10.1021/jm801354e
	CHEMBL475384	12558	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	252	5	2	2	3.4	NC[C@H]1C[C@@H]1c1cccc(NCc2ccccc2)c1	10.1021/jm801354e
	137632218	156303	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	342	2	0	4	3.6	O=C(c1csc(-c2cccc(Cl)c2Cl)n1)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4065444	156303	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	342	2	0	4	3.6	O=C(c1csc(-c2cccc(Cl)c2Cl)n1)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	44572306	12542	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	3.0	NC[C@H]1C[C@@H]1c1ccc(-c2ccco2)cc1	10.1021/jm801354e
	CHEMBL1186669	12542	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	3.0	NC[C@H]1C[C@@H]1c1ccc(-c2ccco2)cc1	10.1021/jm801354e
	CHEMBL474206	12542	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	3.0	NC[C@H]1C[C@@H]1c1ccc(-c2ccco2)cc1	10.1021/jm801354e
	11300712	141686	None	0	Human	Functional	pEC50	=	7.9	7.9	2	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL385577	141686	None	0	Human	Functional	pEC50	=	7.9	7.9	2	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	11579853	89085	None	0	Human	Functional	pEC50	=	7.9	7.9	70	2	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337504	89085	None	0	Human	Functional	pEC50	=	7.9	7.9	70	2	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365200	89085	None	0	Human	Functional	pEC50	=	7.9	7.9	70	2	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	58911582	91099	None	0	Human	Functional	pEC50	=	7.9	7.9	16	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397894	91099	None	0	Human	Functional	pEC50	=	7.9	7.9	16	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	24826871	91112	None	0	Human	Functional	pEC50	=	7.9	7.9	85	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397907	91112	None	0	Human	Functional	pEC50	=	7.9	7.9	85	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	162657053	183681	None	0	Human	Functional	pEC50	=	7.9	7.9	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183681	None	0	Human	Functional	pEC50	=	7.9	7.9	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183681	None	0	Human	Functional	pEC50	=	7.9	7.9	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	44573160	187422	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	392	4	1	4	2.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CC(Oc2cccc(Cl)c2)C1	10.1016/j.bmcl.2009.02.071
	CHEMBL493757	187422	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	392	4	1	4	2.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CC(Oc2cccc(Cl)c2)C1	10.1016/j.bmcl.2009.02.071
	137645674	158010	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	348	3	2	2	4.0	Cc1[nH]c(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4085497	158010	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	348	3	2	2	4.0	Cc1[nH]c(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	137642857	158458	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	373	4	0	4	4.9	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N(C)Cc1cccnc1	10.1021/acs.jmedchem.7b00385
	CHEMBL4090637	158458	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	373	4	0	4	4.9	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N(C)Cc1cccnc1	10.1021/acs.jmedchem.7b00385
	155540515	176462	None	0	Human	Functional	pEC50	=	7.9	7.9	1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@]1(F)c1cccc(Cl)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4516935	176462	None	0	Human	Functional	pEC50	=	7.9	7.9	1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@]1(F)c1cccc(Cl)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4596490	176462	None	0	Human	Functional	pEC50	=	7.9	7.9	1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@]1(F)c1cccc(Cl)c1	10.1016/j.ejmech.2019.111626
	3906894	101979	None	24	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1016/s0960-894x(00)00400-5
	CHEMBL301466	101979	None	24	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1016/s0960-894x(00)00400-5
	44404883	72062	None	32	Human	Functional	pEC50	=	7.9	7.9	2	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL197664	72062	None	32	Human	Functional	pEC50	=	7.9	7.9	2	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	17954204	63938	None	23	Human	Functional	pEC50	=	7.9	7.9	7	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180668	63938	None	23	Human	Functional	pEC50	=	7.9	7.9	7	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2004.12.080
	10331841	169204	None	6	Human	Functional	pEC50	=	7.9	7.9	46	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL440752	169204	None	6	Human	Functional	pEC50	=	7.9	7.9	46	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	162657053	183681	None	0	Human	Functional	pEC50	=	7.9	7.9	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183681	None	0	Human	Functional	pEC50	=	7.9	7.9	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183681	None	0	Human	Functional	pEC50	=	7.9	7.9	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	134265618	164055	None	0	Human	Functional	pEC50	=	7.9	7.9	204	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4209052	164055	None	0	Human	Functional	pEC50	=	7.9	7.9	204	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	155540515	176462	None	0	Human	Functional	pEC50	=	7.9	7.9	1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@]1(F)c1cccc(Cl)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4516935	176462	None	0	Human	Functional	pEC50	=	7.9	7.9	1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@]1(F)c1cccc(Cl)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4596490	176462	None	0	Human	Functional	pEC50	=	7.9	7.9	1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@]1(F)c1cccc(Cl)c1	10.1016/j.ejmech.2019.111626
	17954204	63938	None	23	Human	Functional	pEC50	=	7.9	7.9	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	CHEMBL180668	63938	None	23	Human	Functional	pEC50	=	7.9	7.9	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	10465263	64332	None	63	Human	Functional	pEC50	=	7.9	7.9	19	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL181172	64332	None	63	Human	Functional	pEC50	=	7.9	7.9	19	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL4790446	214071	None	2	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL4803723	214071	None	2	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	1355	2011	None	88	Human	Functional	pEC50	=	7.9	7.9	4	6	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2016.11.016
	142	2011	None	88	Human	Functional	pEC50	=	7.9	7.9	4	6	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2016.11.016
	CHEMBL478	2011	None	88	Human	Functional	pEC50	=	7.9	7.9	4	6	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2016.11.016
	DB12110	2011	None	88	Human	Functional	pEC50	=	7.9	7.9	4	6	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2016.11.016
	16747713	88030	None	0	Rat	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	263	4	1	4	1.6	COCc1c2c(c(C[C@@H](C)N)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL234464	88030	None	0	Rat	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	263	4	1	4	1.6	COCc1c2c(c(C[C@@H](C)N)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL4790446	214071	None	2	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL4803723	214071	None	2	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Cl	10.1021/acsmedchemlett.1c00694
	137629964	161026	None	0	Human	Functional	pEC50	=	7.9	7.9	21	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	235	6	1	2	2.7	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CNC	10.1021/acs.jmedchem.7b00584
	CHEMBL4098721	161026	None	0	Human	Functional	pEC50	=	7.9	7.9	21	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	235	6	1	2	2.7	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CNC	10.1021/acs.jmedchem.7b00584
	CHEMBL4116380	161026	None	0	Human	Functional	pEC50	=	7.9	7.9	21	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	235	6	1	2	2.7	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CNC	10.1021/acs.jmedchem.7b00584
	46228430	199738	None	0	Human	Functional	pEC50	=	6.9	6.9	4	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL593545	199738	None	0	Human	Functional	pEC50	=	6.9	6.9	4	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	137646604	161215	None	0	Human	Functional	pEC50	=	6.9	6.9	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	291	6	1	3	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1cccs1	10.1021/acs.jmedchem.7b00584
	CHEMBL4085380	161215	None	0	Human	Functional	pEC50	=	6.9	6.9	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	291	6	1	3	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1cccs1	10.1021/acs.jmedchem.7b00584
	CHEMBL4117915	161215	None	0	Human	Functional	pEC50	=	6.9	6.9	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	291	6	1	3	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1cccs1	10.1021/acs.jmedchem.7b00584
	27559	203409	None	11	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	CHEMBL6557	203409	None	11	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	70693926	74459	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	217	5	1	2	2.5	NC[C@H]1C[C@@H]1c1ccccc1OCC1CC1	10.1021/ml200206z
	CHEMBL2022189	74459	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	217	5	1	2	2.5	NC[C@H]1C[C@@H]1c1ccccc1OCC1CC1	10.1021/ml200206z
	CHEMBL2027896	74459	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	217	5	1	2	2.5	NC[C@H]1C[C@@H]1c1ccccc1OCC1CC1	10.1021/ml200206z
	7153	98020	None	77	Human	Functional	pEC50	=	6.9	6.9	-1	4	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	CHEMBL272942	98020	None	77	Human	Functional	pEC50	=	6.9	6.9	-1	4	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	137628797	160990	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1ccc(F)cc1C1CC1CNCc1sccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4103313	160990	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1ccc(F)cc1C1CC1CNCc1sccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4116143	160990	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1ccc(F)cc1C1CC1CNCc1sccc1OC	10.1021/acs.jmedchem.7b00584
	137646604	161215	None	0	Human	Functional	pEC50	=	6.9	6.9	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	291	6	1	3	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1cccs1	10.1021/acs.jmedchem.7b00584
	CHEMBL4085380	161215	None	0	Human	Functional	pEC50	=	6.9	6.9	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	291	6	1	3	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1cccs1	10.1021/acs.jmedchem.7b00584
	CHEMBL4117915	161215	None	0	Human	Functional	pEC50	=	6.9	6.9	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	291	6	1	3	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1cccs1	10.1021/acs.jmedchem.7b00584
	46228423	200056	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	360	4	1	6	3.3	Clc1cccc(COc2nc(N3CCNCC3)nc3sccc23)c1	10.1016/j.bmcl.2009.10.112
	CHEMBL595646	200056	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	360	4	1	6	3.3	Clc1cccc(COc2nc(N3CCNCC3)nc3sccc23)c1	10.1016/j.bmcl.2009.10.112
	137628895	160978	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)cc1	10.1021/acs.jmedchem.7b00584
	CHEMBL4078425	160978	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)cc1	10.1021/acs.jmedchem.7b00584
	CHEMBL4115999	160978	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)cc1	10.1021/acs.jmedchem.7b00584
	72197308	102490	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAgonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	290	2	1	6	-0.0	CN1CCN(c2nc3c(c(N(C)C)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393233	102490	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAgonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	290	2	1	6	-0.0	CN1CCN(c2nc3c(c(N(C)C)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040291	102490	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAgonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	290	2	1	6	-0.0	CN1CCN(c2nc3c(c(N(C)C)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	14515726	87305	None	5	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	168	1	1	4	0.4	COc1noc2c1CCNCC2	10.1021/jm301656h
	CHEMBL2331792	87305	None	5	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	168	1	1	4	0.4	COc1noc2c1CCNCC2	10.1021/jm301656h
	137628895	160978	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)cc1	10.1021/acs.jmedchem.7b00584
	CHEMBL4078425	160978	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)cc1	10.1021/acs.jmedchem.7b00584
	CHEMBL4115999	160978	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)cc1	10.1021/acs.jmedchem.7b00584
	14515726	87305	None	5	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	168	1	1	4	0.4	COc1noc2c1CCNCC2	10.1021/jm301656h
	CHEMBL2331792	87305	None	5	Human	Functional	pEC50	=	4.9	4.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	168	1	1	4	0.4	COc1noc2c1CCNCC2	10.1021/jm301656h
	137628797	160990	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1ccc(F)cc1C1CC1CNCc1sccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4103313	160990	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1ccc(F)cc1C1CC1CNCc1sccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4116143	160990	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1ccc(F)cc1C1CC1CNCc1sccc1OC	10.1021/acs.jmedchem.7b00584
	70681346	74463	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	231	5	1	2	2.9	NC[C@H]1C[C@@H]1c1ccccc1OCC1CCC1	10.1021/ml200206z
	CHEMBL2022190	74463	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	231	5	1	2	2.9	NC[C@H]1C[C@@H]1c1ccccc1OCC1CCC1	10.1021/ml200206z
	CHEMBL2027922	74463	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	231	5	1	2	2.9	NC[C@H]1C[C@@H]1c1ccccc1OCC1CCC1	10.1021/ml200206z
	118733764	120645	None	0	Human	Functional	pEC50	=	5.9	5.9	2	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416034	120645	None	0	Human	Functional	pEC50	=	5.9	5.9	2	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546890	120645	None	0	Human	Functional	pEC50	=	5.9	5.9	2	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	3356430	193046	None	2	Human	Functional	pEC50	=	6.9	6.9	-3	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5208864	193046	None	2	Human	Functional	pEC50	=	6.9	6.9	-3	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222941	193046	None	2	Human	Functional	pEC50	=	6.9	6.9	-3	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	27559	203409	None	11	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	CHEMBL6557	203409	None	11	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	3356430	193046	None	2	Human	Functional	pEC50	=	6.9	6.9	-3	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5208864	193046	None	2	Human	Functional	pEC50	=	6.9	6.9	-3	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222941	193046	None	2	Human	Functional	pEC50	=	6.9	6.9	-3	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	25070907	61457	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770376	61457	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	45484682	198371	None	0	Human	Functional	pEC50	=	6.9	6.9	3	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	323	2	1	4	2.0	O=c1cc2c(nn1Cc1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL576651	198371	None	0	Human	Functional	pEC50	=	6.9	6.9	3	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	323	2	1	4	2.0	O=c1cc2c(nn1Cc1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	134136722	142644	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	270	2	1	2	3.1	c1cc(CC2CCC2)c2c(c1)N1CCCNCC1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3891704	142644	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	270	2	1	2	3.1	c1cc(CC2CCC2)c2c(c1)N1CCCNCC1CC2	10.1016/j.bmcl.2016.11.016
	134136932	142656	None	0	Human	Functional	pEC50	=	6.9	6.9	7	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	216	0	1	2	2.2	c1ccc2c(c1)CCC1CCNCCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3891802	142656	None	0	Human	Functional	pEC50	=	6.9	6.9	7	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	216	0	1	2	2.2	c1ccc2c(c1)CCC1CCNCCCN21	10.1016/j.bmcl.2016.11.016
	134133531	143595	None	0	Human	Functional	pEC50	=	6.9	6.9	19	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	264	1	1	2	3.1	c1ccc(-c2cccc3c2CCC2CNCCN32)cc1	10.1016/j.bmcl.2016.11.016
	CHEMBL3899449	143595	None	0	Human	Functional	pEC50	=	6.9	6.9	19	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	264	1	1	2	3.1	c1ccc(-c2cccc3c2CCC2CNCCN32)cc1	10.1016/j.bmcl.2016.11.016
	10774796	79675	None	0	Rat	Functional	pEC50	=	6.9	6.9	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	210	2	1	2	2.3	C[C@@H](N)Cn1ccc2cc(F)c(F)cc21	10.1021/jm970030l
	CHEMBL2115252	79675	None	0	Rat	Functional	pEC50	=	6.9	6.9	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	210	2	1	2	2.3	C[C@@H](N)Cn1ccc2cc(F)c(F)cc21	10.1021/jm970030l
	46228441	199865	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	246	3	1	6	0.6	CCCn1cnc2c(N3CCNCC3)ncnc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594489	199865	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	246	3	1	6	0.6	CCCn1cnc2c(N3CCNCC3)ncnc21	10.1016/j.bmcl.2009.10.112
	118733812	120642	None	0	Human	Functional	pEC50	=	5.9	5.9	4	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3416058	120642	None	0	Human	Functional	pEC50	=	5.9	5.9	4	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3546873	120642	None	0	Human	Functional	pEC50	=	5.9	5.9	4	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	24773648	64425	None	2	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)CCNCC2C	10.1021/jm0709034
	CHEMBL181324	64425	None	2	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)CCNCC2C	10.1021/jm0709034
	168286082	192923	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	273	1	2	3	3.0	Fc1ccc2[nH]c3c(c2c1)CCNC3c1nccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5191954	192923	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	273	1	2	3	3.0	Fc1ccc2[nH]c3c(c2c1)CCNC3c1nccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222230	192923	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	273	1	2	3	3.0	Fc1ccc2[nH]c3c(c2c1)CCNC3c1nccs1	10.1021/acsmedchemlett.1c00694
	134153263	152794	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	216	0	1	2	2.1	CC1(C)CC2CNCCN2c2ccccc21	10.1016/j.bmcl.2016.11.016
	CHEMBL3973690	152794	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	216	0	1	2	2.1	CC1(C)CC2CNCCN2c2ccccc21	10.1016/j.bmcl.2016.11.016
	10631592	207193	None	0	Rat	Functional	pEC50	=	5.9	5.9	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	192	2	1	2	2.1	CC(N)Cn1ccc2c(F)cccc21	10.1021/jm970030l
	CHEMBL92565	207193	None	0	Rat	Functional	pEC50	=	5.9	5.9	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	192	2	1	2	2.1	CC(N)Cn1ccc2c(F)cccc21	10.1021/jm970030l
	10774565	207788	None	0	Rat	Functional	pEC50	=	4.9	4.9	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	204	3	1	3	2.0	COc1cccc2c1ccn2CC(C)N	10.1021/jm970030l
	CHEMBL96095	207788	None	0	Rat	Functional	pEC50	=	4.9	4.9	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	204	3	1	3	2.0	COc1cccc2c1ccn2CC(C)N	10.1021/jm970030l
	168286082	192923	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	273	1	2	3	3.0	Fc1ccc2[nH]c3c(c2c1)CCNC3c1nccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5191954	192923	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	273	1	2	3	3.0	Fc1ccc2[nH]c3c(c2c1)CCNC3c1nccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222230	192923	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	273	1	2	3	3.0	Fc1ccc2[nH]c3c(c2c1)CCNC3c1nccs1	10.1021/acsmedchemlett.1c00694
	11736340	73985	None	55	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	229	1	1	1	3.2	FC(F)(F)c1cccc(C2CCNCC2)c1	10.1016/j.bmcl.2012.01.122
	CHEMBL2011553	73985	None	55	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	229	1	1	1	3.2	FC(F)(F)c1cccc(C2CCNCC2)c1	10.1016/j.bmcl.2012.01.122
	CHEMBL2021656	73985	None	55	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	229	1	1	1	3.2	FC(F)(F)c1cccc(C2CCNCC2)c1	10.1016/j.bmcl.2012.01.122
	137636435	156059	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	326	2	0	4	3.1	O=C(c1csc(-c2cccc(Cl)c2F)n1)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4062613	156059	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	326	2	0	4	3.1	O=C(c1csc(-c2cccc(Cl)c2F)n1)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	702235	53212	None	97	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	200	1	2	1	2.6	c1ccc2c(C3CCNCC3)c[nH]c2c1	10.1016/j.bmcl.2012.01.122
	CHEMBL15988	53212	None	97	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	200	1	2	1	2.6	c1ccc2c(C3CCNCC3)c[nH]c2c1	10.1016/j.bmcl.2012.01.122
	CHEMBL2011564	53212	None	97	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	200	1	2	1	2.6	c1ccc2c(C3CCNCC3)c[nH]c2c1	10.1016/j.bmcl.2012.01.122
	44572164	12683	None	0	Human	Functional	pEC50	=	6.9	6.9	3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL1187390	12683	None	0	Human	Functional	pEC50	=	6.9	6.9	3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL501526	12683	None	0	Human	Functional	pEC50	=	6.9	6.9	3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	168268773	192792	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177208	192792	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221390	192792	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	137647246	157828	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	354	2	0	4	3.7	O=C(c1csc(-c2cccc(Cl)c2Cl)n1)N1CC2CC1CO2	10.1021/acs.jmedchem.7b00385
	CHEMBL4083432	157828	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	354	2	0	4	3.7	O=C(c1csc(-c2cccc(Cl)c2Cl)n1)N1CC2CC1CO2	10.1021/acs.jmedchem.7b00385
	118733762	120644	None	0	Human	Functional	pEC50	=	7.9	7.9	6	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416033	120644	None	0	Human	Functional	pEC50	=	7.9	7.9	6	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546889	120644	None	0	Human	Functional	pEC50	=	7.9	7.9	6	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	137629964	161026	None	0	Human	Functional	pEC50	=	7.9	7.9	21	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	235	6	1	2	2.7	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CNC	10.1021/acs.jmedchem.7b00584
	CHEMBL4098721	161026	None	0	Human	Functional	pEC50	=	7.9	7.9	21	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	235	6	1	2	2.7	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CNC	10.1021/acs.jmedchem.7b00584
	CHEMBL4116380	161026	None	0	Human	Functional	pEC50	=	7.9	7.9	21	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	235	6	1	2	2.7	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CNC	10.1021/acs.jmedchem.7b00584
	12370465	12674	None	18	Human	Functional	pEC50	=	7.9	7.9	6	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL1187354	12674	None	18	Human	Functional	pEC50	=	7.9	7.9	6	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL500093	12674	None	18	Human	Functional	pEC50	=	7.9	7.9	6	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	44572207	12702	None	0	Human	Functional	pEC50	=	7.9	7.9	8	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL1187556	12702	None	0	Human	Functional	pEC50	=	7.9	7.9	8	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL508680	12702	None	0	Human	Functional	pEC50	=	7.9	7.9	8	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	137638508	156831	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	376	4	0	5	4.3	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N(C)Cc1ccn(C)n1	10.1021/acs.jmedchem.7b00385
	CHEMBL4071321	156831	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	376	4	0	5	4.3	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N(C)Cc1ccn(C)n1	10.1021/acs.jmedchem.7b00385
	137647007	157853	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2cccc3ccncc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	CHEMBL4083752	157853	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2cccc3ccncc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	122442286	138351	None	0	Human	Functional	pEC50	=	7.9	7.9	13	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138351	None	0	Human	Functional	pEC50	=	7.9	7.9	13	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138351	None	0	Human	Functional	pEC50	=	7.9	7.9	13	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168273192	190416	None	0	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5177900	190416	None	0	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	122442286	138351	None	0	Human	Functional	pEC50	=	7.9	7.9	13	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138351	None	0	Human	Functional	pEC50	=	7.9	7.9	13	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138351	None	0	Human	Functional	pEC50	=	7.9	7.9	13	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168273192	190416	None	0	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5177900	190416	None	0	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1F	10.1021/acsmedchemlett.1c00694
	122442260	138354	None	0	Human	Functional	pEC50	=	7.9	7.9	2	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138354	None	0	Human	Functional	pEC50	=	7.9	7.9	2	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138354	None	0	Human	Functional	pEC50	=	7.9	7.9	2	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168268773	192792	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177208	192792	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221390	192792	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	155527636	171287	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2cc3c(nn2)CCNCC3)cc1	10.1016/j.bmcl.2016.06.060
	CHEMBL4460600	171287	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2cc3c(nn2)CCNCC3)cc1	10.1016/j.bmcl.2016.06.060
	134136932	142656	None	0	Human	Functional	pEC50	=	6.9	6.9	7	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	216	0	1	2	2.2	c1ccc2c(c1)CCC1CCNCCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3891802	142656	None	0	Human	Functional	pEC50	=	6.9	6.9	7	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	216	0	1	2	2.2	c1ccc2c(c1)CCC1CCNCCCN21	10.1016/j.bmcl.2016.11.016
	18735309	205433	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80246	205433	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	168294156	193005	None	0	Human	Functional	pEC50	=	5.9	5.9	-2	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5207023	193005	None	0	Human	Functional	pEC50	=	5.9	5.9	-2	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222736	193005	None	0	Human	Functional	pEC50	=	5.9	5.9	-2	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168294156	193005	None	0	Human	Functional	pEC50	=	5.9	5.9	-2	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5207023	193005	None	0	Human	Functional	pEC50	=	5.9	5.9	-2	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222736	193005	None	0	Human	Functional	pEC50	=	5.9	5.9	-2	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	118733798	120649	None	0	Human	Functional	pEC50	=	6.9	6.9	12	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416051	120649	None	0	Human	Functional	pEC50	=	6.9	6.9	12	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546894	120649	None	0	Human	Functional	pEC50	=	6.9	6.9	12	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	46230047	199250	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590089	199250	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	122442275	138361	None	0	Human	Functional	pEC50	=	6.9	6.9	9	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138361	None	0	Human	Functional	pEC50	=	6.9	6.9	9	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138361	None	0	Human	Functional	pEC50	=	6.9	6.9	9	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	44573004	12520	None	1	Human	Functional	pEC50	=	6.9	6.9	-3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL1186590	12520	None	1	Human	Functional	pEC50	=	6.9	6.9	-3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL471202	12520	None	1	Human	Functional	pEC50	=	6.9	6.9	-3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	122442275	138361	None	0	Human	Functional	pEC50	=	6.9	6.9	9	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138361	None	0	Human	Functional	pEC50	=	6.9	6.9	9	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138361	None	0	Human	Functional	pEC50	=	6.9	6.9	9	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	11195293	91088	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@]12CNCCN1C(=O)c1ccccc1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397883	91088	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@]12CNCCN1C(=O)c1ccccc1C2	10.1016/j.bmcl.2013.04.061
	11290492	138001	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL376456	138001	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	44572369	12458	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186108	12458	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL450178	12458	None	0	Human	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	9839494	102469	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	305	0	2	3	2.1	O=C1Nc2cc(C(F)(F)F)c(Cl)cc2N2CCNCC12	10.1016/s0960-894x(00)00400-5
	CHEMBL304013	102469	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	305	0	2	3	2.1	O=C1Nc2cc(C(F)(F)F)c(Cl)cc2N2CCNCC12	10.1016/s0960-894x(00)00400-5
	46228424	202195	None	2	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	281	1	1	5	0.9	Brc1cn2ccnc2c(N2CCNCC2)n1	10.1016/j.bmcl.2009.10.112
	CHEMBL609595	202195	None	2	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	281	1	1	5	0.9	Brc1cn2ccnc2c(N2CCNCC2)n1	10.1016/j.bmcl.2009.10.112
	46230046	199247	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	203	0	2	3	0.2	O=C1NC2CNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590077	199247	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	203	0	2	3	0.2	O=C1NC2CNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	162650828	183650	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	285	6	1	3	3.8	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCC3CC3)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4750271	183650	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	285	6	1	3	3.8	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCC3CC3)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802701	183650	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	285	6	1	3	3.8	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCC3CC3)ccc2o1	10.1021/acs.jmedchem.6b01194
	44573002	12686	None	1	Human	Functional	pEC50	=	6.9	6.9	19	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	CHEMBL1187408	12686	None	1	Human	Functional	pEC50	=	6.9	6.9	19	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	CHEMBL501854	12686	None	1	Human	Functional	pEC50	=	6.9	6.9	19	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	162650828	183650	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	285	6	1	3	3.8	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCC3CC3)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4750271	183650	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	285	6	1	3	3.8	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCC3CC3)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802701	183650	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	285	6	1	3	3.8	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCC3CC3)ccc2o1	10.1021/acs.jmedchem.6b01194
	11209786	137240	None	0	Human	Functional	pEC50	=	7.9	7.9	36	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL375170	137240	None	0	Human	Functional	pEC50	=	7.9	7.9	36	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	24826867	91095	None	0	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397890	91095	None	0	Human	Functional	pEC50	=	7.9	7.9	1	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	24826963	91115	None	0	Human	Functional	pEC50	=	7.9	7.9	74	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	0	1	2	1.3	Cc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397910	91115	None	0	Human	Functional	pEC50	=	7.9	7.9	74	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	0	1	2	1.3	Cc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	25084025	12701	None	1	Human	Functional	pEC50	=	7.9	7.9	10	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL1187522	12701	None	1	Human	Functional	pEC50	=	7.9	7.9	10	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL506727	12701	None	1	Human	Functional	pEC50	=	7.9	7.9	10	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	44573162	172593	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	406	4	1	4	2.9	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CC[C@@H](Oc2ccccc2Cl)C1	10.1016/j.bmcl.2009.02.071
	CHEMBL448971	172593	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	406	4	1	4	2.9	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CC[C@@H](Oc2ccccc2Cl)C1	10.1016/j.bmcl.2009.02.071
	137652713	158532	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	340	5	0	4	4.0	COCCN(C)C(=O)c1sc(-c2cccc3ccccc23)nc1C	10.1021/acs.jmedchem.7b00385
	CHEMBL4091448	158532	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	340	5	0	4	4.0	COCCN(C)C(=O)c1sc(-c2cccc3ccccc23)nc1C	10.1021/acs.jmedchem.7b00385
	122442260	138354	None	0	Human	Functional	pEC50	=	7.9	7.9	2	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138354	None	0	Human	Functional	pEC50	=	7.9	7.9	2	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138354	None	0	Human	Functional	pEC50	=	7.9	7.9	2	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	162645074	183624	None	0	Human	Functional	pEC50	=	7.8	7.8	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183624	None	0	Human	Functional	pEC50	=	7.8	7.8	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183624	None	0	Human	Functional	pEC50	=	7.8	7.8	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	136044083	111667	None	1	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	255	2	2	4	1.5	Oc1nc(Cc2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	CHEMBL3286558	111667	None	1	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	255	2	2	4	1.5	Oc1nc(Cc2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	5132936	192833	None	1	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5181253	192833	None	1	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221648	192833	None	1	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	168274581	192814	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5176473	192814	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221497	192814	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	5132936	192833	None	1	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5181253	192833	None	1	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221648	192833	None	1	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	2	3.6	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	168274581	192814	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5176473	192814	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221497	192814	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	1355	2011	None	88	Human	Functional	pEC50	=	7.8	7.8	4	6	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	142	2011	None	88	Human	Functional	pEC50	=	7.8	7.8	4	6	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	CHEMBL478	2011	None	88	Human	Functional	pEC50	=	7.8	7.8	4	6	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	DB12110	2011	None	88	Human	Functional	pEC50	=	7.8	7.8	4	6	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	162645074	183624	None	0	Human	Functional	pEC50	=	7.8	7.8	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183624	None	0	Human	Functional	pEC50	=	7.8	7.8	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183624	None	0	Human	Functional	pEC50	=	7.8	7.8	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	1355	2011	None	88	Human	Functional	pEC50	=	7.8	7.8	4	6	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	142	2011	None	88	Human	Functional	pEC50	=	7.8	7.8	4	6	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	CHEMBL478	2011	None	88	Human	Functional	pEC50	=	7.8	7.8	4	6	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	DB12110	2011	None	88	Human	Functional	pEC50	=	7.8	7.8	4	6	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	1355	2011	None	88	Human	Functional	pEC50	=	7.8	7.8	4	6	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/acs.jmedchem.7b00385
	142	2011	None	88	Human	Functional	pEC50	=	7.8	7.8	4	6	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/acs.jmedchem.7b00385
	CHEMBL478	2011	None	88	Human	Functional	pEC50	=	7.8	7.8	4	6	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/acs.jmedchem.7b00385
	DB12110	2011	None	88	Human	Functional	pEC50	=	7.8	7.8	4	6	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/acs.jmedchem.7b00385
	137647926	157770	None	0	Human	Functional	pEC50	=	7.8	7.8	58	2	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	300	3	0	4	4.2	CCn1nc(-c2cccc3ccccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	CHEMBL4082753	157770	None	0	Human	Functional	pEC50	=	7.8	7.8	58	2	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	300	3	0	4	4.2	CCn1nc(-c2cccc3ccccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	44409290	74651	None	0	Human	Functional	pEC50	=	7.8	7.8	1	2	Efficacy against human recombinant 5HT2C receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2C receptor induced intracellular calcium mobilization in CHO cells by FLIPR	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL203013	74651	None	0	Human	Functional	pEC50	=	7.8	7.8	1	2	Efficacy against human recombinant 5HT2C receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2C receptor induced intracellular calcium mobilization in CHO cells by FLIPR	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL4752798	214065	None	0	Human	Functional	pEC50	=	7.8	7.8	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4802821	214065	None	0	Human	Functional	pEC50	=	7.8	7.8	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4752798	214065	None	0	Human	Functional	pEC50	=	7.8	7.8	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4802821	214065	None	0	Human	Functional	pEC50	=	7.8	7.8	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442254	138345	None	0	Human	Functional	pEC50	=	7.8	7.8	26	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138345	None	0	Human	Functional	pEC50	=	7.8	7.8	26	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138345	None	0	Human	Functional	pEC50	=	7.8	7.8	26	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	57888169	192907	None	0	Human	Functional	pEC50	=	7.8	7.8	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5194866	192907	None	0	Human	Functional	pEC50	=	7.8	7.8	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222124	192907	None	0	Human	Functional	pEC50	=	7.8	7.8	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	23652278	62631	None	17	Human	Functional	pEC50	=	7.8	7.8	16	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL178365	62631	None	17	Human	Functional	pEC50	=	7.8	7.8	16	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	57888169	192907	None	0	Human	Functional	pEC50	=	7.8	7.8	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5194866	192907	None	0	Human	Functional	pEC50	=	7.8	7.8	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222124	192907	None	0	Human	Functional	pEC50	=	7.8	7.8	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	3	2	1	4.6	Clc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	12901777	137998	None	32	Human	Functional	pEC50	=	5.8	5.8	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	188	0	1	2	0.8	O=C1c2ccccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL376455	137998	None	32	Human	Functional	pEC50	=	5.8	5.8	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	188	0	1	2	0.8	O=C1c2ccccc2C2CNCCN12	10.1021/jm0612968
	72197481	102402	None	0	Human	Functional	pEC50	=	5.8	5.8	-4	2	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	356	3	2	6	1.8	CN1CCN(c2nc3c(c(Nc4ccc(F)cc4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393240	102402	None	0	Human	Functional	pEC50	=	5.8	5.8	-4	2	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	356	3	2	6	1.8	CN1CCN(c2nc3c(c(Nc4ccc(F)cc4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	CHEMBL3039632	102402	None	0	Human	Functional	pEC50	=	5.8	5.8	-4	2	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	356	3	2	6	1.8	CN1CCN(c2nc3c(c(Nc4ccc(F)cc4)n2)CCNCC3)CC1	10.1016/j.ejmech.2013.02.020
	122442266	138343	None	0	Human	Functional	pEC50	=	6.8	6.8	51	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138343	None	0	Human	Functional	pEC50	=	6.8	6.8	51	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138343	None	0	Human	Functional	pEC50	=	6.8	6.8	51	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168280043	192859	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5188736	192859	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221859	192859	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	4312735	192874	None	1	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192874	None	1	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192874	None	1	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	122442266	138343	None	0	Human	Functional	pEC50	=	6.8	6.8	51	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138343	None	0	Human	Functional	pEC50	=	6.8	6.8	51	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138343	None	0	Human	Functional	pEC50	=	6.8	6.8	51	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	168280043	192859	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5188736	192859	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221859	192859	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	4	3	2.8	Oc1ccc(C2NCCc3c2[nH]c2ccc(O)cc32)cc1	10.1021/acsmedchemlett.1c00694
	4312735	192874	None	1	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192874	None	1	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192874	None	1	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	137641376	158260	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	356	2	0	4	3.9	Cc1sc(-c2cccc(Cl)c2Cl)nc1C(=O)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4088662	158260	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	356	2	0	4	3.9	Cc1sc(-c2cccc(Cl)c2Cl)nc1C(=O)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	137645858	157899	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	324	2	0	4	3.4	O=C(c1cnc(-c2cccc3ccccc23)s1)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4084236	157899	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	324	2	0	4	3.4	O=C(c1cnc(-c2cccc3ccccc23)s1)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	25071230	111670	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	1	4	1.8	CN(C)c1nc(Cc2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	CHEMBL3286563	111670	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	1	4	1.8	CN(C)c1nc(Cc2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	118733820	120666	None	0	Human	Functional	pEC50	=	6.8	6.8	4	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416062	120666	None	0	Human	Functional	pEC50	=	6.8	6.8	4	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546957	120666	None	0	Human	Functional	pEC50	=	6.8	6.8	4	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	44572258	12687	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	3	1	1	4.1	NC[C@H]1C[C@@H]1c1cccc(-c2ccc(Cl)cc2)c1	10.1021/jm801354e
	CHEMBL1187449	12687	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	3	1	1	4.1	NC[C@H]1C[C@@H]1c1cccc(-c2ccc(Cl)cc2)c1	10.1021/jm801354e
	CHEMBL502979	12687	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	3	1	1	4.1	NC[C@H]1C[C@@H]1c1cccc(-c2ccc(Cl)cc2)c1	10.1021/jm801354e
	11128034	73978	None	15	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	227	1	1	1	3.1	FC(F)(F)c1cccc(C2=CCNCC2)c1	10.1016/j.bmcl.2012.01.122
	CHEMBL2011565	73978	None	15	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	227	1	1	1	3.1	FC(F)(F)c1cccc(C2=CCNCC2)c1	10.1016/j.bmcl.2012.01.122
	CHEMBL2021626	73978	None	15	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	227	1	1	1	3.1	FC(F)(F)c1cccc(C2=CCNCC2)c1	10.1016/j.bmcl.2012.01.122
	3572096	192898	None	1	Human	Functional	pEC50	=	6.8	6.8	2	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	192898	None	1	Human	Functional	pEC50	=	6.8	6.8	2	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	192898	None	1	Human	Functional	pEC50	=	6.8	6.8	2	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	168288743	192947	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	192947	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	192947	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	134138627	148042	None	0	Human	Functional	pEC50	=	6.8	6.8	-19	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	266	1	1	3	2.5	COc1ccc2c(c1Cl)N1CCCNC[C@H]1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3934644	148042	None	0	Human	Functional	pEC50	=	6.8	6.8	-19	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	266	1	1	3	2.5	COc1ccc2c(c1Cl)N1CCCNC[C@H]1CC2	10.1016/j.bmcl.2016.11.016
	12834	207926	None	26	Rat	Functional	pEC50	=	6.8	6.8	-18	2	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	192	2	2	1	2.2	CC(N)Cc1c[nH]c2ccc(F)cc12	10.1021/jm970030l
	CHEMBL96816	207926	None	26	Rat	Functional	pEC50	=	6.8	6.8	-18	2	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	192	2	2	1	2.2	CC(N)Cc1c[nH]c2ccc(F)cc12	10.1021/jm970030l
	44420683	84133	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	0	1	2	2.6	CC1(C)CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	CHEMBL220789	84133	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	0	1	2	2.6	CC1(C)CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	4240627	192934	None	1	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198376	192934	None	1	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222297	192934	None	1	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	9964324	207933	None	2	Rat	Functional	pEC50	=	5.8	5.8	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	192	2	1	2	2.1	CC(N)Cn1ccc2cc(F)ccc21	10.1021/jm970030l
	CHEMBL96883	207933	None	2	Rat	Functional	pEC50	=	5.8	5.8	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	192	2	1	2	2.1	CC(N)Cn1ccc2cc(F)ccc21	10.1021/jm970030l
	3572096	192898	None	1	Human	Functional	pEC50	=	6.8	6.8	2	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	192898	None	1	Human	Functional	pEC50	=	6.8	6.8	2	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	192898	None	1	Human	Functional	pEC50	=	6.8	6.8	2	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	168288743	192947	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	192947	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	192947	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	11302765	84248	None	4	Human	Functional	pEC50	=	7.8	7.8	74	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL221113	84248	None	4	Human	Functional	pEC50	=	7.8	7.8	74	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	24826787	91097	None	0	Human	Functional	pEC50	=	7.8	7.8	6	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2c(cccc2C(F)(F)F)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397892	91097	None	0	Human	Functional	pEC50	=	7.8	7.8	6	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2c(cccc2C(F)(F)F)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	71681897	91119	None	0	Human	Functional	pEC50	=	7.8	7.8	87	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	258	0	1	3	1.0	O=C1c2ccc3c(c2C[C@@H]2CNCCN12)OCCC3	10.1016/j.bmcl.2013.04.061
	CHEMBL2397914	91119	None	0	Human	Functional	pEC50	=	7.8	7.8	87	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	258	0	1	3	1.0	O=C1c2ccc3c(c2C[C@@H]2CNCCN12)OCCC3	10.1016/j.bmcl.2013.04.061
	44572806	12654	None	1	Human	Functional	pEC50	=	7.8	7.8	4	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1187195	12654	None	1	Human	Functional	pEC50	=	7.8	7.8	4	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL493129	12654	None	1	Human	Functional	pEC50	=	7.8	7.8	4	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	46230097	199366	None	0	Human	Functional	pEC50	=	7.8	7.8	6	3	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590816	199366	None	0	Human	Functional	pEC50	=	7.8	7.8	6	3	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	25070577	111666	None	4	Human	Functional	pEC50	=	7.8	7.8	6	5	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	304	3	2	4	2.3	CNc1nc(C(F)(F)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	CHEMBL3286557	111666	None	4	Human	Functional	pEC50	=	7.8	7.8	6	5	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	304	3	2	4	2.3	CNc1nc(C(F)(F)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	137654798	158928	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	349	3	1	4	3.2	Cc1nn(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4095663	158928	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	349	3	1	4	3.2	Cc1nn(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	122442250	138344	None	0	Human	Functional	pEC50	=	7.8	7.8	8	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138344	None	0	Human	Functional	pEC50	=	7.8	7.8	8	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138344	None	0	Human	Functional	pEC50	=	7.8	7.8	8	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442254	138345	None	0	Human	Functional	pEC50	=	7.8	7.8	26	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138345	None	0	Human	Functional	pEC50	=	7.8	7.8	26	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138345	None	0	Human	Functional	pEC50	=	7.8	7.8	26	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	23652278	62631	None	17	Human	Functional	pEC50	=	7.8	7.8	16	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178365	62631	None	17	Human	Functional	pEC50	=	7.8	7.8	16	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	1497577	158872	None	15	Human	Functional	pEC50	=	7.8	7.8	-	1	Positive allosteric modulation of human 5-HT2C receptor expressed in human HeLa-K1 cells assessed as potentiation of 5-HT-induced inositol monophosphate release after 20 mins by HTRF assayPositive allosteric modulation of human 5-HT2C receptor expressed in human HeLa-K1 cells assessed as potentiation of 5-HT-induced inositol monophosphate release after 20 mins by HTRF assay	ChEMBL	313	5	1	3	4.7	c1ccc(Cn2cc(CNc3cccnc3)c3ccccc32)cc1	10.1021/acs.jmedchem.7b00994
	CHEMBL4095079	158872	None	15	Human	Functional	pEC50	=	7.8	7.8	-	1	Positive allosteric modulation of human 5-HT2C receptor expressed in human HeLa-K1 cells assessed as potentiation of 5-HT-induced inositol monophosphate release after 20 mins by HTRF assayPositive allosteric modulation of human 5-HT2C receptor expressed in human HeLa-K1 cells assessed as potentiation of 5-HT-induced inositol monophosphate release after 20 mins by HTRF assay	ChEMBL	313	5	1	3	4.7	c1ccc(Cn2cc(CNc3cccnc3)c3ccccc32)cc1	10.1021/acs.jmedchem.7b00994
	11658860	2344	None	51	Dog	Functional	pEC50	=	7.8	7.8	-1	11	Agonist activity at dog 5HT2C receptorAgonist activity at dog 5HT2C receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	2941	2344	None	51	Dog	Functional	pEC50	=	7.8	7.8	-1	11	Agonist activity at dog 5HT2C receptorAgonist activity at dog 5HT2C receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	4374	2344	None	51	Dog	Functional	pEC50	=	7.8	7.8	-1	11	Agonist activity at dog 5HT2C receptorAgonist activity at dog 5HT2C receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL360328	2344	None	51	Dog	Functional	pEC50	=	7.8	7.8	-1	11	Agonist activity at dog 5HT2C receptorAgonist activity at dog 5HT2C receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	DB04871	2344	None	51	Dog	Functional	pEC50	=	7.8	7.8	-1	11	Agonist activity at dog 5HT2C receptorAgonist activity at dog 5HT2C receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	122442250	138344	None	0	Human	Functional	pEC50	=	7.8	7.8	8	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138344	None	0	Human	Functional	pEC50	=	7.8	7.8	8	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138344	None	0	Human	Functional	pEC50	=	7.8	7.8	8	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442263	138357	None	0	Human	Functional	pEC50	=	7.8	7.8	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138357	None	0	Human	Functional	pEC50	=	7.8	7.8	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138357	None	0	Human	Functional	pEC50	=	7.8	7.8	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	107992	2553	None	49	Human	Functional	pEC50	=	6.8	6.8	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	165	2553	None	49	Human	Functional	pEC50	=	6.8	6.8	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	CHEMBL269521	2553	None	49	Human	Functional	pEC50	=	6.8	6.8	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	DB12111	2553	None	49	Human	Functional	pEC50	=	6.8	6.8	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	45484910	198577	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	348	4	1	6	1.7	Cc1ccc(Cl)cc1OCc1nc(N2CCNCC2)cc(=O)n1C	10.1016/j.bmcl.2009.07.133
	CHEMBL578365	198577	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	348	4	1	6	1.7	Cc1ccc(Cl)cc1OCc1nc(N2CCNCC2)cc(=O)n1C	10.1016/j.bmcl.2009.07.133
	10379910	63301	None	0	Human	Functional	pEC50	=	6.8	6.8	6	2	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.3	COc1cc2c(cc1Br)C(C(C)C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179329	63301	None	0	Human	Functional	pEC50	=	6.8	6.8	6	2	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.3	COc1cc2c(cc1Br)C(C(C)C)CNCC2	10.1016/j.bmcl.2004.12.080
	137637069	156008	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2cccc3cnccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	CHEMBL4062011	156008	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2cccc3cnccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	4240627	192934	None	1	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198376	192934	None	1	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222297	192934	None	1	Human	Functional	pEC50	=	5.8	5.8	-2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	44572761	12680	None	0	Human	Functional	pEC50	=	6.8	6.8	3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL1187377	12680	None	0	Human	Functional	pEC50	=	6.8	6.8	3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL501117	12680	None	0	Human	Functional	pEC50	=	6.8	6.8	3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	107992	2553	None	49	Human	Functional	pEC50	=	6.8	6.8	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	165	2553	None	49	Human	Functional	pEC50	=	6.8	6.8	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	CHEMBL269521	2553	None	49	Human	Functional	pEC50	=	6.8	6.8	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	DB12111	2553	None	49	Human	Functional	pEC50	=	6.8	6.8	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	137629850	161196	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	303	6	1	2	3.9	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1F	10.1021/acs.jmedchem.7b00584
	CHEMBL4073406	161196	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	303	6	1	2	3.9	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1F	10.1021/acs.jmedchem.7b00584
	CHEMBL4117722	161196	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	303	6	1	2	3.9	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1F	10.1021/acs.jmedchem.7b00584
	2761023	98766	None	71	Human	Functional	pEC50	=	6.8	6.8	-43	3	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	198	1	2	1	2.5	C1=C(c2c[nH]c3ccccc23)CCNC1	10.1016/j.bmcl.2012.01.122
	CHEMBL2011570	98766	None	71	Human	Functional	pEC50	=	6.8	6.8	-43	3	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	198	1	2	1	2.5	C1=C(c2c[nH]c3ccccc23)CCNC1	10.1016/j.bmcl.2012.01.122
	CHEMBL27811	98766	None	71	Human	Functional	pEC50	=	6.8	6.8	-43	3	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	198	1	2	1	2.5	C1=C(c2c[nH]c3ccccc23)CCNC1	10.1016/j.bmcl.2012.01.122
	45484848	198778	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	342	6	1	6	1.8	Cc1cc(=O)n(CCCOc2ccccc2)c(N2CCNC[C@H]2C)n1	10.1016/j.bmcl.2009.07.133
	CHEMBL583192	198778	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	342	6	1	6	1.8	Cc1cc(=O)n(CCCOc2ccccc2)c(N2CCNC[C@H]2C)n1	10.1016/j.bmcl.2009.07.133
	2794808	200038	None	76	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	203	1	1	4	1.2	c1cc2occc2c(N2CCNCC2)n1	10.1016/j.bmcl.2009.10.112
	CHEMBL595555	200038	None	76	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	203	1	1	4	1.2	c1cc2occc2c(N2CCNCC2)n1	10.1016/j.bmcl.2009.10.112
	45485751	197655	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	334	5	1	6	1.4	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1Cl	10.1016/j.bmcl.2009.07.136
	CHEMBL570937	197655	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	334	5	1	6	1.4	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1Cl	10.1016/j.bmcl.2009.07.136
	137629850	161196	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	303	6	1	2	3.9	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1F	10.1021/acs.jmedchem.7b00584
	CHEMBL4073406	161196	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	303	6	1	2	3.9	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1F	10.1021/acs.jmedchem.7b00584
	CHEMBL4117722	161196	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	303	6	1	2	3.9	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1F	10.1021/acs.jmedchem.7b00584
	122442268	138353	None	0	Human	Functional	pEC50	=	6.8	6.8	7	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769633	138353	None	0	Human	Functional	pEC50	=	6.8	6.8	7	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771389	138353	None	0	Human	Functional	pEC50	=	6.8	6.8	7	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122461993	138359	None	0	Human	Functional	pEC50	=	6.8	6.8	3	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769581	138359	None	0	Human	Functional	pEC50	=	6.8	6.8	3	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771395	138359	None	0	Human	Functional	pEC50	=	6.8	6.8	3	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442268	138353	None	0	Human	Functional	pEC50	=	6.8	6.8	7	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769633	138353	None	0	Human	Functional	pEC50	=	6.8	6.8	7	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771389	138353	None	0	Human	Functional	pEC50	=	6.8	6.8	7	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122461993	138359	None	0	Human	Functional	pEC50	=	6.8	6.8	3	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769581	138359	None	0	Human	Functional	pEC50	=	6.8	6.8	3	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771395	138359	None	0	Human	Functional	pEC50	=	6.8	6.8	3	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	137645024	158069	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	300	3	0	4	4.2	CCn1nc(-c2cccc3ccccc23)cc1-c1ncccn1	10.1021/acs.jmedchem.7b00385
	CHEMBL4086216	158069	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	300	3	0	4	4.2	CCn1nc(-c2cccc3ccccc23)cc1-c1ncccn1	10.1021/acs.jmedchem.7b00385
	16115644	136960	None	0	Human	Functional	pEC50	=	7.8	7.8	1	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374436	136960	None	0	Human	Functional	pEC50	=	7.8	7.8	1	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	11666237	89112	None	0	Human	Functional	pEC50	=	7.8	7.8	30	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337496	89112	None	0	Human	Functional	pEC50	=	7.8	7.8	30	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365472	89112	None	0	Human	Functional	pEC50	=	7.8	7.8	30	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	137631812	156568	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	366	2	1	4	4.3	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCCC(O)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4068476	156568	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	366	2	1	4	4.3	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCCC(O)CC1	10.1021/acs.jmedchem.7b00385
	1355	2011	None	88	Human	Functional	pEC50	=	6.8	6.8	4	6	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	142	2011	None	88	Human	Functional	pEC50	=	6.8	6.8	4	6	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	CHEMBL478	2011	None	88	Human	Functional	pEC50	=	6.8	6.8	4	6	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	DB12110	2011	None	88	Human	Functional	pEC50	=	6.8	6.8	4	6	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	44573165	187203	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	390	6	1	5	2.2	COc1cc(S(=O)(=O)N(C)Cc2ccccc2)c(OC)c2c1CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492362	187203	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	390	6	1	5	2.2	COc1cc(S(=O)(=O)N(C)Cc2ccccc2)c(OC)c2c1CCNCC2	10.1016/j.bmcl.2009.02.071
	1355	2011	None	88	Human	Functional	pEC50	=	6.8	6.8	4	6	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	142	2011	None	88	Human	Functional	pEC50	=	6.8	6.8	4	6	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	CHEMBL478	2011	None	88	Human	Functional	pEC50	=	6.8	6.8	4	6	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	DB12110	2011	None	88	Human	Functional	pEC50	=	6.8	6.8	4	6	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	14515725	87310	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	CHEMBL2331807	87310	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	58911604	91106	None	1	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2ccc(Cl)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397901	91106	None	1	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2ccc(Cl)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	168274213	192810	None	0	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5178487	192810	None	0	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221472	192810	None	0	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	168291006	192975	None	0	Human	Functional	pEC50	=	6.8	6.8	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5199780	192975	None	0	Human	Functional	pEC50	=	6.8	6.8	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5222544	192975	None	0	Human	Functional	pEC50	=	6.8	6.8	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	168274213	192810	None	0	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5178487	192810	None	0	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221472	192810	None	0	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)cc1O	10.1021/acsmedchemlett.1c00694
	168291006	192975	None	0	Human	Functional	pEC50	=	6.8	6.8	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5199780	192975	None	0	Human	Functional	pEC50	=	6.8	6.8	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5222544	192975	None	0	Human	Functional	pEC50	=	6.8	6.8	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	380	1	2	2	5.2	Cc1cc(C2NCCc3c2[nH]c2ccc(Cl)cc32)sc1Br	10.1021/acsmedchemlett.1c00694
	16115148	84839	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	206	0	1	2	0.9	O=C1c2c(F)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL223469	84839	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	206	0	1	2	0.9	O=C1c2c(F)cccc2C2CNCCN12	10.1021/jm0612968
	14515725	87310	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	CHEMBL2331807	87310	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	58911681	90985	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
	CHEMBL2396668	90985	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
	168282202	192884	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192884	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192884	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	45484742	198518	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	243	3	2	3	1.7	c1ccc(COc2n[nH]c3c2CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	CHEMBL577903	198518	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	243	3	2	3	1.7	c1ccc(COc2n[nH]c3c2CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	185717	4448	None	24	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	193	1	1	1	2.7	Clc1ccc(C2=CCNCC2)cc1	10.1016/j.bmcl.2012.01.122
	CHEMBL101664	4448	None	24	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	193	1	1	1	2.7	Clc1ccc(C2=CCNCC2)cc1	10.1016/j.bmcl.2012.01.122
	CHEMBL2011566	4448	None	24	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	193	1	1	1	2.7	Clc1ccc(C2=CCNCC2)cc1	10.1016/j.bmcl.2012.01.122
	118733784	120662	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	6	1	3	3.1	CSCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416044	120662	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	6	1	3	3.1	CSCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546953	120662	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	6	1	3	3.1	CSCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	168282202	192884	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192884	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192884	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	16115267	84793	None	0	Human	Functional	pEC50	=	7.8	7.8	2	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL223272	84793	None	0	Human	Functional	pEC50	=	7.8	7.8	2	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	11176570	91120	None	1	Human	Functional	pEC50	=	7.8	7.8	6	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2cc(C(F)(F)F)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397915	91120	None	1	Human	Functional	pEC50	=	7.8	7.8	6	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2cc(C(F)(F)F)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	44572170	12465	None	1	Human	Functional	pEC50	=	7.8	7.8	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL1186164	12465	None	1	Human	Functional	pEC50	=	7.8	7.8	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL452458	12465	None	1	Human	Functional	pEC50	=	7.8	7.8	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	70683433	74458	None	1	Human	Functional	pEC50	=	7.8	7.8	18	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022185	74458	None	1	Human	Functional	pEC50	=	7.8	7.8	18	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027895	74458	None	1	Human	Functional	pEC50	=	7.8	7.8	18	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	53325936	56802	None	0	Human	Functional	pEC50	=	7.8	7.8	12	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643675	56802	None	0	Human	Functional	pEC50	=	7.8	7.8	12	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	137633983	156471	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	342	2	0	4	3.6	O=C(c1nc(-c2cccc(Cl)c2Cl)cs1)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4067417	156471	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	342	2	0	4	3.6	O=C(c1nc(-c2cccc(Cl)c2Cl)cs1)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	122442307	138355	None	0	Human	Functional	pEC50	=	7.8	7.8	1	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3770950	138355	None	0	Human	Functional	pEC50	=	7.8	7.8	1	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771391	138355	None	0	Human	Functional	pEC50	=	7.8	7.8	1	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	166	3359	None	18	Human	Functional	pEC50	=	7.8	7.8	-2	4	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	3045227	3359	None	18	Human	Functional	pEC50	=	7.8	7.8	-2	4	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76781	3359	None	18	Human	Functional	pEC50	=	7.8	7.8	-2	4	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	122442307	138355	None	0	Human	Functional	pEC50	=	7.7	7.7	1	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3770950	138355	None	0	Human	Functional	pEC50	=	7.7	7.7	1	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771391	138355	None	0	Human	Functional	pEC50	=	7.7	7.7	1	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	54583743	61463	None	0	Human	Functional	pEC50	=	6.8	6.8	-5	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770382	61463	None	0	Human	Functional	pEC50	=	6.8	6.8	-5	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	44383397	59242	None	0	Human	Functional	pEC50	=	6.8	6.8	6	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line	ChEMBL	246	3	1	2	3.1	CNCCc1cn2c3c(cc(F)cc13)CCC2C	10.1016/s0960-894x(00)00141-4
	CHEMBL170319	59242	None	0	Human	Functional	pEC50	=	6.8	6.8	6	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line	ChEMBL	246	3	1	2	3.1	CNCCc1cn2c3c(cc(F)cc13)CCC2C	10.1016/s0960-894x(00)00141-4
	44412150	77733	None	0	Human	Functional	pEC50	=	6.8	6.8	1	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL208936	77733	None	0	Human	Functional	pEC50	=	6.8	6.8	1	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	146464686	191997	None	0	Human	Functional	pEC50	=	4.8	4.8	-8	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	3	4	1.9	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201492	191997	None	0	Human	Functional	pEC50	=	4.8	4.8	-8	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	3	4	1.9	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	137633009	156412	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	349	3	1	4	3.1	Cn1cc(-c2cccc3ccccc23)nc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4066653	156412	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	349	3	1	4	3.1	Cn1cc(-c2cccc3ccccc23)nc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	46884099	8204	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor	ChEMBL	348	4	2	2	4.0	O=C(NCc1ccc(-c2cc(Cl)cc(Cl)c2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1092167	8204	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor	ChEMBL	348	4	2	2	4.0	O=C(NCc1ccc(-c2cc(Cl)cc(Cl)c2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	118733782	120661	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416043	120661	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546952	120661	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	11150514	84877	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@H]2CNCCN12	10.1021/jm0612968
	CHEMBL223584	84877	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@H]2CNCCN12	10.1021/jm0612968
	3939391	192950	None	1	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5197949	192950	None	1	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222415	192950	None	1	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	44573223	187200	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	296	2	1	4	0.4	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCOCC1	10.1016/j.bmcl.2009.02.071
	CHEMBL492357	187200	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	296	2	1	4	0.4	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCOCC1	10.1016/j.bmcl.2009.02.071
	3939391	192950	None	1	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5197949	192950	None	1	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222415	192950	None	1	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	2	1	4.7	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	137631000	161138	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	319	6	1	2	4.4	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1Cl	10.1021/acs.jmedchem.7b00584
	CHEMBL4083787	161138	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	319	6	1	2	4.4	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1Cl	10.1021/acs.jmedchem.7b00584
	CHEMBL4117262	161138	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	319	6	1	2	4.4	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1Cl	10.1021/acs.jmedchem.7b00584
	137631000	161138	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	319	6	1	2	4.4	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1Cl	10.1021/acs.jmedchem.7b00584
	CHEMBL4083787	161138	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	319	6	1	2	4.4	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1Cl	10.1021/acs.jmedchem.7b00584
	CHEMBL4117262	161138	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	319	6	1	2	4.4	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1ccccc1Cl	10.1021/acs.jmedchem.7b00584
	10966027	201991	None	50	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	219	1	1	4	1.7	c1cc2sccc2c(N2CCNCC2)n1	10.1016/j.bmcl.2009.10.112
	CHEMBL608135	201991	None	50	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	219	1	1	4	1.7	c1cc2sccc2c(N2CCNCC2)n1	10.1016/j.bmcl.2009.10.112
	137643658	158202	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	363	3	1	4	3.4	Cc1nc(-c2cccc3ccccc23)n(C)c1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4087951	158202	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	363	3	1	4	3.4	Cc1nc(-c2cccc3ccccc23)n(C)c1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	53317924	56851	None	0	Human	Functional	pEC50	=	6.7	6.7	6	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643858	56851	None	0	Human	Functional	pEC50	=	6.7	6.7	6	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	162643473	183615	None	0	Human	Functional	pEC50	=	7.7	7.7	14	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183615	None	0	Human	Functional	pEC50	=	7.7	7.7	14	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183615	None	0	Human	Functional	pEC50	=	7.7	7.7	14	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	44302714	102759	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	291	0	2	3	2.6	FC(F)(F)c1cc2c(cc1Cl)N1CCNC[C@@H]1CN2	10.1016/s0960-894x(00)00400-5
	CHEMBL305123	102759	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	291	0	2	3	2.6	FC(F)(F)c1cc2c(cc1Cl)N1CCNC[C@@H]1CN2	10.1016/s0960-894x(00)00400-5
	10017993	201073	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	305	0	2	3	2.1	O=C1Nc2cc(C(F)(F)F)c(Cl)cc2N2CCNC[C@H]12	10.1016/s0960-894x(00)00400-5
	CHEMBL60280	201073	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	305	0	2	3	2.1	O=C1Nc2cc(C(F)(F)F)c(Cl)cc2N2CCNC[C@H]12	10.1016/s0960-894x(00)00400-5
	162643473	183615	None	0	Human	Functional	pEC50	=	7.7	7.7	14	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183615	None	0	Human	Functional	pEC50	=	7.7	7.7	14	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183615	None	0	Human	Functional	pEC50	=	7.7	7.7	14	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	11160564	63304	None	4	Human	Functional	pEC50	=	7.7	7.7	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	CHEMBL179337	63304	None	4	Human	Functional	pEC50	=	7.7	7.7	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	24773728	94860	None	0	Human	Functional	pEC50	=	7.7	7.7	15	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253810	94860	None	0	Human	Functional	pEC50	=	7.7	7.7	15	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	11264345	130399	None	5	Human	Functional	pEC50	=	7.7	7.7	38	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	CHEMBL368016	130399	None	5	Human	Functional	pEC50	=	7.7	7.7	38	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	134132665	144557	None	0	Human	Functional	pEC50	=	7.7	7.7	39	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	258	2	1	3	2.3	c1cc(OC2CCC2)c2c(c1)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3907399	144557	None	0	Human	Functional	pEC50	=	7.7	7.7	39	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	258	2	1	3	2.3	c1cc(OC2CCC2)c2c(c1)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	134148291	150081	None	0	Human	Functional	pEC50	=	7.7	7.7	31	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	230	2	1	2	2.4	CCCc1ccc2c(c1)CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3950846	150081	None	0	Human	Functional	pEC50	=	7.7	7.7	31	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	230	2	1	2	2.4	CCCc1ccc2c(c1)CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	134155992	151392	None	0	Human	Functional	pEC50	=	7.7	7.7	398	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	310	2	1	2	3.5	Fc1ccc2c(c1Cc1ccccc1)CC[C@@H]1CNCCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3961589	151392	None	0	Human	Functional	pEC50	=	7.7	7.7	398	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	310	2	1	2	3.5	Fc1ccc2c(c1Cc1ccccc1)CC[C@@H]1CNCCCN21	10.1016/j.bmcl.2016.11.016
	134151626	153404	None	0	Human	Functional	pEC50	=	7.7	7.7	63	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	232	2	1	3	1.6	COCc1cccc2c1CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3978882	153404	None	0	Human	Functional	pEC50	=	7.7	7.7	63	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	232	2	1	3	1.6	COCc1cccc2c1CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	25070582	61454	None	28	Human	Functional	pEC50	=	6.7	6.7	-2	9	Agonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770373	61454	None	28	Human	Functional	pEC50	=	6.7	6.7	-2	9	Agonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	25070582	61454	None	28	Human	Functional	pEC50	=	6.7	6.7	-2	9	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1021/jm5003292
	CHEMBL1770373	61454	None	28	Human	Functional	pEC50	=	6.7	6.7	-2	9	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1021/jm5003292
	137655535	158995	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	303	3	0	5	3.5	CCn1nc(-c2cccc3ccccc23)cc1-c1ncnn1C	10.1021/acs.jmedchem.7b00385
	CHEMBL4096385	158995	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	303	3	0	5	3.5	CCn1nc(-c2cccc3ccccc23)cc1-c1ncnn1C	10.1021/acs.jmedchem.7b00385
	155512645	169683	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.3	CC(c1ccccc1)c1cc2c(nn1)CCNCC2	10.1016/j.bmcl.2016.06.060
	CHEMBL4437696	169683	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.3	CC(c1ccccc1)c1cc2c(nn1)CCNCC2	10.1016/j.bmcl.2016.06.060
	168275195	192823	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5181991	192823	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221539	192823	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	168282109	192883	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183544	192883	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221988	192883	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	54585651	61452	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	4	1	3	2.3	c1ccc(CCCc2ncc3c(n2)CCNC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770367	61452	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	4	1	3	2.3	c1ccc(CCCc2ncc3c(n2)CCNC3)cc1	10.1016/j.bmcl.2010.11.120
	168275195	192823	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5181991	192823	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221539	192823	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	1	3	2	3.4	Cc1cccc(C2NCCc3c2[nH]c2ccc(O)cc32)c1	10.1021/acsmedchemlett.1c00694
	168282109	192883	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5183544	192883	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221988	192883	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	301	1	2	3	3.7	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	54581791	61464	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770383	61464	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	71681898	91089	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	0	2	1.0	CN1CCN2C(=O)c3ccccc3C[C@@H]2C1	10.1016/j.bmcl.2013.04.061
	CHEMBL2397884	91089	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	0	2	1.0	CN1CCN2C(=O)c3ccccc3C[C@@H]2C1	10.1016/j.bmcl.2013.04.061
	54583742	61456	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770375	61456	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	168279029	192854	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5188817	192854	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221792	192854	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	168279029	192854	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5188817	192854	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	CHEMBL5221792	192854	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	358	1	4	3	3.6	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cc(Br)ccc1O	10.1021/acsmedchemlett.1c00694
	44572254	12554	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	263	3	1	2	4.2	NC[C@H]1C[C@@H]1c1ccccc1-c1cc2ccccc2o1	10.1021/jm801354e
	CHEMBL1186710	12554	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	263	3	1	2	4.2	NC[C@H]1C[C@@H]1c1ccccc1-c1cc2ccccc2o1	10.1021/jm801354e
	CHEMBL475021	12554	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	263	3	1	2	4.2	NC[C@H]1C[C@@H]1c1ccccc1-c1cc2ccccc2o1	10.1021/jm801354e
	44573218	193057	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	320	3	2	3	2.3	O=S(=O)(Nc1ccccc1F)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL522349	193057	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	320	3	2	3	2.3	O=S(=O)(Nc1ccccc1F)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	24773900	123432	None	8	Human	Functional	pEC50	=	6.7	6.7	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	CHEMBL361742	123432	None	8	Human	Functional	pEC50	=	6.7	6.7	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	24773978	154416	None	1	Human	Functional	pEC50	=	6.7	6.7	7	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	0	1	1	2.8	CC1(C)CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL398926	154416	None	1	Human	Functional	pEC50	=	6.7	6.7	7	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	0	1	1	2.8	CC1(C)CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	168275014	192820	None	0	Human	Functional	pEC50	=	6.7	6.7	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177386	192820	None	0	Human	Functional	pEC50	=	6.7	6.7	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221524	192820	None	0	Human	Functional	pEC50	=	6.7	6.7	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	134141640	147276	None	0	Human	Functional	pEC50	=	6.7	6.7	3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	250	0	1	2	2.8	Clc1ccc2c(c1)CCC1CCNCCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3928762	147276	None	0	Human	Functional	pEC50	=	6.7	6.7	3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	250	0	1	2	2.8	Clc1ccc2c(c1)CCC1CCNCCCN21	10.1016/j.bmcl.2016.11.016
	166	3359	None	18	Rat	Functional	pEC50	=	6.7	6.7	-79	4	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm970030l
	3045227	3359	None	18	Rat	Functional	pEC50	=	6.7	6.7	-79	4	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm970030l
	CHEMBL76781	3359	None	18	Rat	Functional	pEC50	=	6.7	6.7	-79	4	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm970030l
	18516642	111810	None	0	Rat	Functional	pEC50	=	6.7	6.7	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	254	2	1	2	3.5	Cc1ccc2c(c1)-c1c(ccn1CC(C)N)C2(C)C	10.1021/jm970030l
	CHEMBL328761	111810	None	0	Rat	Functional	pEC50	=	6.7	6.7	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	254	2	1	2	3.5	Cc1ccc2c(c1)-c1c(ccn1CC(C)N)C2(C)C	10.1021/jm970030l
	10330734	156936	None	0	Rat	Functional	pEC50	=	6.7	6.7	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	210	2	1	2	2.3	C[C@H](N)Cn1ccc2cc(F)c(F)cc21	10.1021/jm970030l
	CHEMBL40726	156936	None	0	Rat	Functional	pEC50	=	6.7	6.7	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	210	2	1	2	2.3	C[C@H](N)Cn1ccc2cc(F)c(F)cc21	10.1021/jm970030l
	19036480	207466	None	0	Rat	Functional	pEC50	=	6.7	6.7	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	258	2	1	2	3.3	CC(N)Cn1ccc2c1-c1cc(F)ccc1C2(C)C	10.1021/jm970030l
	CHEMBL94272	207466	None	0	Rat	Functional	pEC50	=	6.7	6.7	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	258	2	1	2	3.3	CC(N)Cn1ccc2c1-c1cc(F)ccc1C2(C)C	10.1021/jm970030l
	12763911	73976	None	80	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	175	1	1	1	2.5	Cc1cccc(C2CCNCC2)c1	10.1016/j.bmcl.2012.01.122
	CHEMBL2011548	73976	None	80	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	175	1	1	1	2.5	Cc1cccc(C2CCNCC2)c1	10.1016/j.bmcl.2012.01.122
	CHEMBL2021617	73976	None	80	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	175	1	1	1	2.5	Cc1cccc(C2CCNCC2)c1	10.1016/j.bmcl.2012.01.122
	10538127	98079	None	0	Rat	Functional	pEC50	=	5.7	5.7	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	242	3	1	3	2.4	COc1ccc2c(c1)Cc1ccn(CC(C)N)c1-2	10.1021/jm970030l
	CHEMBL273304	98079	None	0	Rat	Functional	pEC50	=	5.7	5.7	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	242	3	1	3	2.4	COc1ccc2c(c1)Cc1ccn(CC(C)N)c1-2	10.1021/jm970030l
	10753358	98571	None	2	Rat	Functional	pEC50	=	5.7	5.7	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	252	2	1	2	2.8	CC(N)Cn1ccc2cc(Br)ccc21	10.1021/jm970030l
	CHEMBL276673	98571	None	2	Rat	Functional	pEC50	=	5.7	5.7	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	252	2	1	2	2.8	CC(N)Cn1ccc2cc(Br)ccc21	10.1021/jm970030l
	9855823	111979	None	3	Rat	Functional	pEC50	=	5.7	5.7	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	208	2	1	2	2.6	CC(N)Cn1ccc2cc(Cl)ccc21	10.1021/jm970030l
	CHEMBL328844	111979	None	3	Rat	Functional	pEC50	=	5.7	5.7	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	208	2	1	2	2.6	CC(N)Cn1ccc2cc(Cl)ccc21	10.1021/jm970030l
	11695000	89071	None	0	Human	Functional	pEC50	=	8.7	8.7	7	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	89071	None	0	Human	Functional	pEC50	=	8.7	8.7	7	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	89071	None	0	Human	Functional	pEC50	=	8.7	8.7	7	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	46230098	199329	None	0	Human	Functional	pEC50	=	8.7	8.7	30	4	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590580	199329	None	0	Human	Functional	pEC50	=	8.7	8.7	30	4	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	137661673	159349	None	0	Human	Functional	pEC50	=	8.7	8.7	1	3	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2cccc3cccnc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	CHEMBL4100216	159349	None	0	Human	Functional	pEC50	=	8.7	8.7	1	3	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2cccc3cccnc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	10064386	63317	None	4	Human	Functional	pEC50	=	8.7	8.7	30	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179378	63317	None	4	Human	Functional	pEC50	=	8.7	8.7	30	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	11658860	2344	None	51	Human	Functional	pEC50	=	8.7	8.7	1	11	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.7b00584
	2941	2344	None	51	Human	Functional	pEC50	=	8.7	8.7	1	11	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.7b00584
	4374	2344	None	51	Human	Functional	pEC50	=	8.7	8.7	1	11	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.7b00584
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.7	8.7	1	11	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.7b00584
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.7	8.7	1	11	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.7b00584
	57799324	89092	None	0	Human	Functional	pEC50	=	8.7	8.7	9	2	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337501	89092	None	0	Human	Functional	pEC50	=	8.7	8.7	9	2	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365359	89092	None	0	Human	Functional	pEC50	=	8.7	8.7	9	2	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	166	3359	None	18	Human	Functional	pEC50	=	8.7	8.7	-2	4	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/acs.jmedchem.6b01194
	3045227	3359	None	18	Human	Functional	pEC50	=	8.7	8.7	-2	4	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/acs.jmedchem.6b01194
	CHEMBL76781	3359	None	18	Human	Functional	pEC50	=	8.7	8.7	-2	4	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/acs.jmedchem.6b01194
	166	3359	None	18	Human	Functional	pEC50	=	8.7	8.7	-2	4	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/acs.jmedchem.6b01194
	3045227	3359	None	18	Human	Functional	pEC50	=	8.7	8.7	-2	4	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/acs.jmedchem.6b01194
	CHEMBL76781	3359	None	18	Human	Functional	pEC50	=	8.7	8.7	-2	4	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/acs.jmedchem.6b01194
	46830177	8061	None	30	Human	Functional	pEC50	=	8.6	8.6	190	2	Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor	ChEMBL	378	6	2	4	3.6	COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1091105	8061	None	30	Human	Functional	pEC50	=	8.6	8.6	190	2	Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor	ChEMBL	378	6	2	4	3.6	COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	10219723	179109	None	22	Human	Functional	pEC50	=	8.6	8.6	17	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells by [3H]-inositol phosphate accumulation assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells by [3H]-inositol phosphate accumulation assay	ChEMBL	185	2	1	1	2.7	CC(N)Cc1ccc2ccccc2c1	10.1039/C6MD00245E
	CHEMBL471839	179109	None	22	Human	Functional	pEC50	=	8.6	8.6	17	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells by [3H]-inositol phosphate accumulation assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells by [3H]-inositol phosphate accumulation assay	ChEMBL	185	2	1	1	2.7	CC(N)Cc1ccc2ccccc2c1	10.1039/C6MD00245E
	137630842	161114	None	0	Human	Functional	pEC50	=	8.6	8.6	4	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	347	9	1	3	4.1	COc1ccccc1CNC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.7b00584
	CHEMBL4091672	161114	None	0	Human	Functional	pEC50	=	8.6	8.6	4	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	347	9	1	3	4.1	COc1ccccc1CNC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.7b00584
	CHEMBL4117120	161114	None	0	Human	Functional	pEC50	=	8.6	8.6	4	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	347	9	1	3	4.1	COc1ccccc1CNC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.7b00584
	137630842	161114	None	0	Human	Functional	pEC50	=	8.6	8.6	4	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	347	9	1	3	4.1	COc1ccccc1CNC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.7b00584
	CHEMBL4091672	161114	None	0	Human	Functional	pEC50	=	8.6	8.6	4	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	347	9	1	3	4.1	COc1ccccc1CNC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.7b00584
	CHEMBL4117120	161114	None	0	Human	Functional	pEC50	=	8.6	8.6	4	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	347	9	1	3	4.1	COc1ccccc1CNC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.7b00584
	11171464	149480	None	0	Human	Functional	pEC50	=	8.6	8.6	25	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	188	0	1	2	1.4	c1ccc2c(c1)CC[C@@H]1CNCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3946277	149480	None	0	Human	Functional	pEC50	=	8.6	8.6	25	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	188	0	1	2	1.4	c1ccc2c(c1)CC[C@@H]1CNCCN21	10.1016/j.bmcl.2016.11.016
	162657367	183682	None	0	Human	Functional	pEC50	=	8.6	8.6	32	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183682	None	0	Human	Functional	pEC50	=	8.6	8.6	32	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183682	None	0	Human	Functional	pEC50	=	8.6	8.6	32	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	57799306	89109	None	0	Human	Functional	pEC50	=	8.6	8.6	12	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337493	89109	None	0	Human	Functional	pEC50	=	8.6	8.6	12	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365469	89109	None	0	Human	Functional	pEC50	=	8.6	8.6	12	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	162657367	183682	None	0	Human	Functional	pEC50	=	8.6	8.6	32	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183682	None	0	Human	Functional	pEC50	=	8.6	8.6	32	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183682	None	0	Human	Functional	pEC50	=	8.6	8.6	32	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	72197669	102487	None	0	Human	Functional	pEC50	=	8.6	8.6	-2	2	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	4	2	4	3.6	Fc1ccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393247	102487	None	0	Human	Functional	pEC50	=	8.6	8.6	-2	2	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	4	2	4	3.6	Fc1ccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040281	102487	None	0	Human	Functional	pEC50	=	8.6	8.6	-2	2	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	348	4	2	4	3.6	Fc1ccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	11658860	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	11658860	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.7b00584
	2941	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.7b00584
	4374	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.7b00584
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.7b00584
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.7b00584
	11658860	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	162650400	183649	None	0	Human	Functional	pEC50	=	8.6	8.6	22	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4748110	183649	None	0	Human	Functional	pEC50	=	8.6	8.6	22	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802669	183649	None	0	Human	Functional	pEC50	=	8.6	8.6	22	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	162670523	183750	None	0	Human	Functional	pEC50	=	8.6	8.6	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183750	None	0	Human	Functional	pEC50	=	8.6	8.6	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183750	None	0	Human	Functional	pEC50	=	8.6	8.6	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162650400	183649	None	0	Human	Functional	pEC50	=	8.6	8.6	22	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4748110	183649	None	0	Human	Functional	pEC50	=	8.6	8.6	22	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802669	183649	None	0	Human	Functional	pEC50	=	8.6	8.6	22	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	162670523	183750	None	0	Human	Functional	pEC50	=	8.6	8.6	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183750	None	0	Human	Functional	pEC50	=	8.6	8.6	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183750	None	0	Human	Functional	pEC50	=	8.6	8.6	20	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	11658860	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	2941	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	4374	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	11658860	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.6	8.6	1	11	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	155532108	176566	None	0	Human	Functional	pEC50	=	8.6	8.6	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@]1(F)c1cccc(F)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4466591	176566	None	0	Human	Functional	pEC50	=	8.6	8.6	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@]1(F)c1cccc(F)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4597360	176566	None	0	Human	Functional	pEC50	=	8.6	8.6	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@]1(F)c1cccc(F)c1	10.1016/j.ejmech.2019.111626
	5	139	None	72	Rat	Functional	pEC50	=	8.6	8.6	-40	26	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	5202	139	None	72	Rat	Functional	pEC50	=	8.6	8.6	-40	26	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	CHEMBL39	139	None	72	Rat	Functional	pEC50	=	8.6	8.6	-40	26	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	DB08839	139	None	72	Rat	Functional	pEC50	=	8.6	8.6	-40	26	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	11737939	84227	None	0	Human	Functional	pEC50	=	7.7	7.7	2	2	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL220900	84227	None	0	Human	Functional	pEC50	=	7.7	7.7	2	2	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	11499800	89107	None	0	Human	Functional	pEC50	=	7.7	7.7	10	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337503	89107	None	0	Human	Functional	pEC50	=	7.7	7.7	10	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365465	89107	None	0	Human	Functional	pEC50	=	7.7	7.7	10	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	162652983	183663	None	0	Human	Functional	pEC50	=	7.7	7.7	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183663	None	0	Human	Functional	pEC50	=	7.7	7.7	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183663	None	0	Human	Functional	pEC50	=	7.7	7.7	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	4407909	192866	None	1	Human	Functional	pEC50	=	7.7	7.7	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192866	None	1	Human	Functional	pEC50	=	7.7	7.7	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192866	None	1	Human	Functional	pEC50	=	7.7	7.7	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	137660072	159407	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	365	3	1	3	4.7	Cc1cc(-c2cccc3ccccc23)sc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4100812	159407	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	365	3	1	3	4.7	Cc1cc(-c2cccc3ccccc23)sc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	11160564	63304	None	4	Human	Functional	pEC50	=	7.7	7.7	7	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL179337	63304	None	4	Human	Functional	pEC50	=	7.7	7.7	7	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	72197484	102494	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	9	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393243	102494	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	9	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040324	102494	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	9	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	168276733	192831	None	0	Human	Functional	pEC50	=	7.7	7.7	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5180401	192831	None	0	Human	Functional	pEC50	=	7.7	7.7	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221642	192831	None	0	Human	Functional	pEC50	=	7.7	7.7	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	162652983	183663	None	0	Human	Functional	pEC50	=	7.7	7.7	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183663	None	0	Human	Functional	pEC50	=	7.7	7.7	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183663	None	0	Human	Functional	pEC50	=	7.7	7.7	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	168276733	192831	None	0	Human	Functional	pEC50	=	7.7	7.7	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5180401	192831	None	0	Human	Functional	pEC50	=	7.7	7.7	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221642	192831	None	0	Human	Functional	pEC50	=	7.7	7.7	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	272	1	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3C1CCCCC1	10.1021/acsmedchemlett.1c00694
	4407909	192866	None	1	Human	Functional	pEC50	=	7.7	7.7	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192866	None	1	Human	Functional	pEC50	=	7.7	7.7	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192866	None	1	Human	Functional	pEC50	=	7.7	7.7	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	168275014	192820	None	0	Human	Functional	pEC50	=	6.7	6.7	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177386	192820	None	0	Human	Functional	pEC50	=	6.7	6.7	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221524	192820	None	0	Human	Functional	pEC50	=	6.7	6.7	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	218	1	2	1	2.9	CCC1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	10751567	4539	None	3	Rat	Functional	pEC50	=	5.7	5.7	-	1	Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	CHEMBL102347	4539	None	3	Rat	Functional	pEC50	=	5.7	5.7	-	1	Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	38240	107999	None	22	Rat	Functional	pEC50	=	5.7	5.7	-	1	Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor	ChEMBL	225	6	1	4	1.6	CCOc1c(OC)cc(CCN)cc1OC	10.1021/jm970219x
	CHEMBL319415	107999	None	22	Rat	Functional	pEC50	=	5.7	5.7	-	1	Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor	ChEMBL	225	6	1	4	1.6	CCOc1c(OC)cc(CCN)cc1OC	10.1021/jm970219x
	24773648	64425	None	2	Human	Functional	pEC50	=	5.7	5.7	-	1	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)CCNCC2C	10.1016/j.bmcl.2004.12.080
	CHEMBL181324	64425	None	2	Human	Functional	pEC50	=	5.7	5.7	-	1	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)CCNCC2C	10.1016/j.bmcl.2004.12.080
	4401618	193023	None	5	Human	Functional	pEC50	=	5.7	5.7	-9	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5207633	193023	None	5	Human	Functional	pEC50	=	5.7	5.7	-9	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222820	193023	None	5	Human	Functional	pEC50	=	5.7	5.7	-9	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	4401618	193023	None	5	Human	Functional	pEC50	=	5.7	5.7	-9	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5207633	193023	None	5	Human	Functional	pEC50	=	5.7	5.7	-9	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222820	193023	None	5	Human	Functional	pEC50	=	5.7	5.7	-9	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	118733814	120658	None	0	Human	Functional	pEC50	=	6.7	6.7	23	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3416059	120658	None	0	Human	Functional	pEC50	=	6.7	6.7	23	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3546910	120658	None	0	Human	Functional	pEC50	=	6.7	6.7	23	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	168285159	192914	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	192914	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	192914	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	4363390	192870	None	2	Human	Functional	pEC50	=	5.7	5.7	-21	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	344	1	2	1	4.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5184885	192870	None	2	Human	Functional	pEC50	=	5.7	5.7	-21	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	344	1	2	1	4.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5221904	192870	None	2	Human	Functional	pEC50	=	5.7	5.7	-21	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	344	1	2	1	4.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	168285159	192914	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	192914	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	192914	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	4363390	192870	None	2	Human	Functional	pEC50	=	5.7	5.7	-21	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	344	1	2	1	4.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5184885	192870	None	2	Human	Functional	pEC50	=	5.7	5.7	-21	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	344	1	2	1	4.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	CHEMBL5221904	192870	None	2	Human	Functional	pEC50	=	5.7	5.7	-21	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	344	1	2	1	4.3	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1Br	10.1021/acsmedchemlett.1c00694
	162668367	183739	None	0	Human	Functional	pEC50	=	7.7	7.7	21	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4786831	183739	None	0	Human	Functional	pEC50	=	7.7	7.7	21	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803642	183739	None	0	Human	Functional	pEC50	=	7.7	7.7	21	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	46937339	74209	None	0	Human	Functional	pEC50	=	7.7	7.7	13	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/ml200206z
	CHEMBL2023357	74209	None	0	Human	Functional	pEC50	=	7.7	7.7	13	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/ml200206z
	46937339	74209	None	0	Human	Functional	pEC50	=	7.7	7.7	13	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium mobilization	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL2023357	74209	None	0	Human	Functional	pEC50	=	7.7	7.7	13	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium mobilization	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/jm5019274
	45484972	198354	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	346	5	1	5	2.1	CCn1c(CCc2ccccc2Cl)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	CHEMBL576453	198354	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	346	5	1	5	2.1	CCn1c(CCc2ccccc2Cl)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	45484934	198438	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	346	4	1	5	2.0	C[C@@H]1CNCCN1c1cc(=O)n(C)c(CCc2ccccc2Cl)n1	10.1016/j.bmcl.2009.07.133
	CHEMBL577250	198438	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	346	4	1	5	2.0	C[C@@H]1CNCCN1c1cc(=O)n(C)c(CCc2ccccc2Cl)n1	10.1016/j.bmcl.2009.07.133
	122442263	138357	None	0	Human	Functional	pEC50	=	7.7	7.7	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138357	None	0	Human	Functional	pEC50	=	7.7	7.7	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138357	None	0	Human	Functional	pEC50	=	7.7	7.7	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44315697	205505	None	0	Human	Functional	pEC50	=	7.7	7.7	1	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL80731	205505	None	0	Human	Functional	pEC50	=	7.7	7.7	1	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	162668367	183739	None	0	Human	Functional	pEC50	=	7.7	7.7	21	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4786831	183739	None	0	Human	Functional	pEC50	=	7.7	7.7	21	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803642	183739	None	0	Human	Functional	pEC50	=	7.7	7.7	21	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	11658860	2344	None	51	Human	Functional	pEC50	=	6.7	6.7	1	11	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	2941	2344	None	51	Human	Functional	pEC50	=	6.7	6.7	1	11	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	4374	2344	None	51	Human	Functional	pEC50	=	6.7	6.7	1	11	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	6.7	6.7	1	11	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	DB04871	2344	None	51	Human	Functional	pEC50	=	6.7	6.7	1	11	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	54587669	61460	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770379	61460	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	53323196	56849	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643856	56849	None	0	Human	Functional	pEC50	=	6.7	6.7	-3	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	118733802	120653	None	0	Human	Functional	pEC50	=	6.7	6.7	1	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416053	120653	None	0	Human	Functional	pEC50	=	6.7	6.7	1	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546905	120653	None	0	Human	Functional	pEC50	=	6.7	6.7	1	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	11673842	89088	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	264	2	2	2	2.1	CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337498	89088	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	264	2	2	2	2.1	CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365254	89088	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	264	2	2	2	2.1	CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	122180957	121772	None	0	Human	Functional	pEC50	=	6.7	6.7	-20	2	Partial agonist activity at human 5-HT2C receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assayPartial agonist activity at human 5-HT2C receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assay	ChEMBL	393	7	1	5	3.5	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1Br	10.1016/j.bmc.2014.12.011
	CHEMBL3589578	121772	None	0	Human	Functional	pEC50	=	6.7	6.7	-20	2	Partial agonist activity at human 5-HT2C receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assayPartial agonist activity at human 5-HT2C receptor expressed in human tsA201 cells after 30 mins by inositol phosphate turnover assay	ChEMBL	393	7	1	5	3.5	COc1cc(CCNCc2cccc3c2OCO3)c(OC)cc1Br	10.1016/j.bmc.2014.12.011
	70696051	74462	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	271	4	1	2	3.6	COc1ccc(-c2ccc(F)cc2)cc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022181	74462	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	271	4	1	2	3.6	COc1ccc(-c2ccc(F)cc2)cc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027920	74462	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	271	4	1	2	3.6	COc1ccc(-c2ccc(F)cc2)cc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	46228422	200036	None	0	Human	Functional	pEC50	=	7.7	7.7	33	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595553	200036	None	0	Human	Functional	pEC50	=	7.7	7.7	33	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	9844378	8094	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assay	ChEMBL	409	5	1	6	3.5	Cc1noc(C)c1COc1cc(F)c(COC(=O)N2[C@@H](C)CNC[C@H]2C)c(F)c1	10.1007/s00044-011-9615-3
	CHEMBL1091452	8094	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assay	ChEMBL	409	5	1	6	3.5	Cc1noc(C)c1COc1cc(F)c(COC(=O)N2[C@@H](C)CNC[C@H]2C)c(F)c1	10.1007/s00044-011-9615-3
	146025688	183694	None	0	Human	Functional	pEC50	=	7.7	7.7	20	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183694	None	0	Human	Functional	pEC50	=	7.7	7.7	20	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183694	None	0	Human	Functional	pEC50	=	7.7	7.7	20	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	118733824	120669	None	0	Human	Functional	pEC50	=	7.7	7.7	75	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.8	C=C(F)COc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416065	120669	None	0	Human	Functional	pEC50	=	7.7	7.7	75	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.8	C=C(F)COc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546960	120669	None	0	Human	Functional	pEC50	=	7.7	7.7	75	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.8	C=C(F)COc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	24826788	91098	None	0	Human	Functional	pEC50	=	7.7	7.7	17	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397893	91098	None	0	Human	Functional	pEC50	=	7.7	7.7	17	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	11264345	130399	None	5	Human	Functional	pEC50	=	7.7	7.7	38	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL368016	130399	None	5	Human	Functional	pEC50	=	7.7	7.7	38	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1016/j.bmcl.2004.12.080
	44412389	78096	None	0	Human	Functional	pEC50	=	7.7	7.7	1	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210215	78096	None	0	Human	Functional	pEC50	=	7.7	7.7	1	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	146025688	183694	None	0	Human	Functional	pEC50	=	7.7	7.7	20	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183694	None	0	Human	Functional	pEC50	=	7.7	7.7	20	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183694	None	0	Human	Functional	pEC50	=	7.7	7.7	20	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	146025689	183717	None	0	Human	Functional	pEC50	=	7.7	7.7	17	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4781163	183717	None	0	Human	Functional	pEC50	=	7.7	7.7	17	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803350	183717	None	0	Human	Functional	pEC50	=	7.7	7.7	17	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168271458	190608	None	0	Human	Functional	pEC50	=	7.7	7.7	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	2	1	3.5	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5180800	190608	None	0	Human	Functional	pEC50	=	7.7	7.7	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	2	1	3.5	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	168271458	190608	None	0	Human	Functional	pEC50	=	7.7	7.7	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	2	1	3.5	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5180800	190608	None	0	Human	Functional	pEC50	=	7.7	7.7	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	2	1	3.5	Fc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	137630214	161059	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	209	4	1	2	2.2	CNC[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4082227	161059	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	209	4	1	2	2.2	CNC[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4116620	161059	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	209	4	1	2	2.2	CNC[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	155539425	172851	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1c(Cc2ccccc2)nnc2c1CCNCC2	10.1016/j.bmcl.2016.06.060
	CHEMBL4514905	172851	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1c(Cc2ccccc2)nnc2c1CCNCC2	10.1016/j.bmcl.2016.06.060
	122442310	138358	None	0	Human	Functional	pEC50	=	6.7	6.7	4	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770011	138358	None	0	Human	Functional	pEC50	=	6.7	6.7	4	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771394	138358	None	0	Human	Functional	pEC50	=	6.7	6.7	4	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	122442310	138358	None	0	Human	Functional	pEC50	=	6.7	6.7	4	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770011	138358	None	0	Human	Functional	pEC50	=	6.7	6.7	4	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771394	138358	None	0	Human	Functional	pEC50	=	6.7	6.7	4	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	137629242	161002	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1cscc1CNCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4070259	161002	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1cscc1CNCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4116195	161002	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1cscc1CNCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	45484878	196820	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	314	4	1	6	1.1	Cc1ccccc1OCc1nc(N2CCNCC2)cc(=O)n1C	10.1016/j.bmcl.2009.07.133
	CHEMBL565735	196820	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	314	4	1	6	1.1	Cc1ccccc1OCc1nc(N2CCNCC2)cc(=O)n1C	10.1016/j.bmcl.2009.07.133
	155551165	176639	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	333	7	1	3	3.8	COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC	10.1016/j.ejmech.2019.111626
	CHEMBL4541617	176639	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	333	7	1	3	3.8	COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC	10.1016/j.ejmech.2019.111626
	CHEMBL4597957	176639	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	333	7	1	3	3.8	COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC	10.1016/j.ejmech.2019.111626
	137629242	161002	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1cscc1CNCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4070259	161002	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1cscc1CNCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4116195	161002	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1cscc1CNCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	137629898	161019	None	0	Human	Functional	pEC50	=	6.6	6.6	16	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1cccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)c1	10.1021/acs.jmedchem.7b00584
	CHEMBL4067525	161019	None	0	Human	Functional	pEC50	=	6.6	6.6	16	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1cccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)c1	10.1021/acs.jmedchem.7b00584
	CHEMBL4116318	161019	None	0	Human	Functional	pEC50	=	6.6	6.6	16	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1cccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)c1	10.1021/acs.jmedchem.7b00584
	71562661	87307	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	CHEMBL2331794	87307	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	155551165	176639	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	333	7	1	3	3.8	COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC	10.1016/j.ejmech.2019.111626
	CHEMBL4541617	176639	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	333	7	1	3	3.8	COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC	10.1016/j.ejmech.2019.111626
	CHEMBL4597957	176639	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	333	7	1	3	3.8	COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC	10.1016/j.ejmech.2019.111626
	146025689	183717	None	0	Human	Functional	pEC50	=	7.6	7.6	17	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4781163	183717	None	0	Human	Functional	pEC50	=	7.6	7.6	17	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803350	183717	None	0	Human	Functional	pEC50	=	7.6	7.6	17	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	137630214	161059	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	209	4	1	2	2.2	CNC[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4082227	161059	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	209	4	1	2	2.2	CNC[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4116620	161059	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	209	4	1	2	2.2	CNC[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	44572755	12459	None	1	Human	Functional	pEC50	=	7.6	7.6	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186115	12459	None	1	Human	Functional	pEC50	=	7.6	7.6	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL450599	12459	None	1	Human	Functional	pEC50	=	7.6	7.6	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	53325937	56805	None	0	Human	Functional	pEC50	=	7.6	7.6	-7	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643678	56805	None	0	Human	Functional	pEC50	=	7.6	7.6	-7	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	24849050	78300	None	2	Human	Functional	pEC50	=	7.6	7.6	2	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210802	78300	None	2	Human	Functional	pEC50	=	7.6	7.6	2	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	137640063	161222	None	2	Human	Functional	pEC50	=	7.6	7.6	4	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccccc1CNC[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4072722	161222	None	2	Human	Functional	pEC50	=	7.6	7.6	4	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccccc1CNC[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4117953	161222	None	2	Human	Functional	pEC50	=	7.6	7.6	4	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccccc1CNC[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	137640063	161222	None	2	Human	Functional	pEC50	=	7.6	7.6	4	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccccc1CNC[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4072722	161222	None	2	Human	Functional	pEC50	=	7.6	7.6	4	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccccc1CNC[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4117953	161222	None	2	Human	Functional	pEC50	=	7.6	7.6	4	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1ccccc1CNC[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	122442300	138349	None	0	Human	Functional	pEC50	=	7.6	7.6	4	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138349	None	0	Human	Functional	pEC50	=	7.6	7.6	4	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138349	None	0	Human	Functional	pEC50	=	7.6	7.6	4	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	122442251	138360	None	0	Human	Functional	pEC50	=	7.6	7.6	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138360	None	0	Human	Functional	pEC50	=	7.6	7.6	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138360	None	0	Human	Functional	pEC50	=	7.6	7.6	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	71562661	87307	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	CHEMBL2331794	87307	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	244	3	1	4	1.9	c1ccc(COc2noc3c2CCNCC3)cc1	10.1021/jm301656h
	24773894	62980	None	3	Human	Functional	pEC50	=	6.6	6.6	9	2	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL178566	62980	None	3	Human	Functional	pEC50	=	6.6	6.6	9	2	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	72197480	102401	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	368	4	2	7	1.7	COc1cccc(Nc2nc(N3CCN(C)CC3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393239	102401	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	368	4	2	7	1.7	COc1cccc(Nc2nc(N3CCN(C)CC3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3039631	102401	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	368	4	2	7	1.7	COc1cccc(Nc2nc(N3CCN(C)CC3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	137629898	161019	None	0	Human	Functional	pEC50	=	6.6	6.6	16	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1cccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)c1	10.1021/acs.jmedchem.7b00584
	CHEMBL4067525	161019	None	0	Human	Functional	pEC50	=	6.6	6.6	16	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1cccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)c1	10.1021/acs.jmedchem.7b00584
	CHEMBL4116318	161019	None	0	Human	Functional	pEC50	=	6.6	6.6	16	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1cccc(CNC[C@H]2C[C@@H]2c2cc(F)ccc2OC)c1	10.1021/acs.jmedchem.7b00584
	44572367	12543	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	CHEMBL1186673	12543	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	CHEMBL474230	12543	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	122442310	138358	None	0	Human	Functional	pEC50	=	6.6	6.6	4	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770011	138358	None	0	Human	Functional	pEC50	=	6.6	6.6	4	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771394	138358	None	0	Human	Functional	pEC50	=	6.6	6.6	4	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	122442310	138358	None	0	Human	Functional	pEC50	=	6.6	6.6	4	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770011	138358	None	0	Human	Functional	pEC50	=	6.6	6.6	4	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771394	138358	None	0	Human	Functional	pEC50	=	6.6	6.6	4	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1c(OCCF)ccc(Cl)c1Cl	10.1021/acs.jmedchem.5b01153
	11414184	83498	None	0	Human	Functional	pEC50	=	7.6	7.6	5	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	CHEMBL220274	83498	None	0	Human	Functional	pEC50	=	7.6	7.6	5	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	70687695	74478	None	0	Human	Functional	pEC50	=	7.6	7.6	12	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022186	74478	None	0	Human	Functional	pEC50	=	7.6	7.6	12	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027987	74478	None	0	Human	Functional	pEC50	=	7.6	7.6	12	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	5	139	None	72	Human	Functional	pEC50	=	7.6	7.6	-3	26	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	5202	139	None	72	Human	Functional	pEC50	=	7.6	7.6	-3	26	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	7.6	7.6	-3	26	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	DB08839	139	None	72	Human	Functional	pEC50	=	7.6	7.6	-3	26	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	137639485	156904	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	336	2	0	3	4.9	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCCCC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4072217	156904	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	336	2	0	3	4.9	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCCCC1	10.1021/acs.jmedchem.7b00385
	122442300	138349	None	0	Human	Functional	pEC50	=	7.6	7.6	4	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138349	None	0	Human	Functional	pEC50	=	7.6	7.6	4	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138349	None	0	Human	Functional	pEC50	=	7.6	7.6	4	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	122442251	138360	None	0	Human	Functional	pEC50	=	7.6	7.6	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138360	None	0	Human	Functional	pEC50	=	7.6	7.6	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138360	None	0	Human	Functional	pEC50	=	7.6	7.6	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL4757837	214068	None	1	Human	Functional	pEC50	=	7.6	7.6	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802974	214068	None	1	Human	Functional	pEC50	=	7.6	7.6	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4757837	214068	None	1	Human	Functional	pEC50	=	7.6	7.6	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802974	214068	None	1	Human	Functional	pEC50	=	7.6	7.6	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc2ccccc2c1	10.1021/acsmedchemlett.1c00694
	13139	2491	None	29	Rat	Functional	pEC50	=	4.6	4.6	-9	2	Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor	ChEMBL	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	10.1021/jm970219x
	4076	2491	None	29	Rat	Functional	pEC50	=	4.6	4.6	-9	2	Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor	ChEMBL	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	10.1021/jm970219x
	CHEMBL26687	2491	None	29	Rat	Functional	pEC50	=	4.6	4.6	-9	2	Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptorEffect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor	ChEMBL	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	10.1021/jm970219x
	11416698	91107	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397902	91107	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	118733786	120663	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	6	1	3	3.1	CSCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416045	120663	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	6	1	3	3.1	CSCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546954	120663	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	6	1	3	3.1	CSCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	137629237	161001	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	310	6	1	3	3.6	COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N	10.1021/acs.jmedchem.7b00584
	CHEMBL4064809	161001	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	310	6	1	3	3.6	COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N	10.1021/acs.jmedchem.7b00584
	CHEMBL4116194	161001	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	310	6	1	3	3.6	COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N	10.1021/acs.jmedchem.7b00584
	137629237	161001	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	310	6	1	3	3.6	COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N	10.1021/acs.jmedchem.7b00584
	CHEMBL4064809	161001	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	310	6	1	3	3.6	COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N	10.1021/acs.jmedchem.7b00584
	CHEMBL4116194	161001	None	0	Human	Functional	pEC50	=	6.6	6.6	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	310	6	1	3	3.6	COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N	10.1021/acs.jmedchem.7b00584
	82553	202795	None	71	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	159	1	1	1	2.1	C1=C(c2ccccc2)CCNC1	10.1016/j.bmcl.2012.01.122
	CHEMBL1901802	202795	None	71	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	159	1	1	1	2.1	C1=C(c2ccccc2)CCNC1	10.1016/j.bmcl.2012.01.122
	CHEMBL6224	202795	None	71	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	159	1	1	1	2.1	C1=C(c2ccccc2)CCNC1	10.1016/j.bmcl.2012.01.122
	16115521	84665	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1cc2c(cc1Cl)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL222466	84665	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1cc2c(cc1Cl)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	118733772	120648	None	0	Human	Functional	pEC50	=	5.6	5.6	2	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416038	120648	None	0	Human	Functional	pEC50	=	5.6	5.6	2	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546893	120648	None	0	Human	Functional	pEC50	=	5.6	5.6	2	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	46228433	199740	None	8	Human	Functional	pEC50	=	7.6	7.6	87	2	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	217	1	1	3	1.4	c1cc2c(nc1N1CCNCC1)CCCC2	10.1016/j.bmcl.2009.10.112
	CHEMBL593547	199740	None	8	Human	Functional	pEC50	=	7.6	7.6	87	2	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	217	1	1	3	1.4	c1cc2c(nc1N1CCNCC1)CCCC2	10.1016/j.bmcl.2009.10.112
	146025689	183717	None	0	Human	Functional	pEC50	=	7.6	7.6	17	2	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4781163	183717	None	0	Human	Functional	pEC50	=	7.6	7.6	17	2	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803350	183717	None	0	Human	Functional	pEC50	=	7.6	7.6	17	2	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11630147	91113	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	2	1	3	1.1	CCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397908	91113	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	2	1	3	1.1	CCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	162653458	183666	None	0	Human	Functional	pEC50	=	7.6	7.6	6	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183666	None	0	Human	Functional	pEC50	=	7.6	7.6	6	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183666	None	0	Human	Functional	pEC50	=	7.6	7.6	6	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	5	139	None	72	Human	Functional	pEC50	=	7.6	7.6	-3	26	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	5202	139	None	72	Human	Functional	pEC50	=	7.6	7.6	-3	26	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	7.6	7.6	-3	26	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	DB08839	139	None	72	Human	Functional	pEC50	=	7.6	7.6	-3	26	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	45485779	197507	None	0	Human	Functional	pEC50	=	7.6	7.6	4	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.8	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2Cl)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL570023	197507	None	0	Human	Functional	pEC50	=	7.6	7.6	4	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.8	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2Cl)n1	10.1016/j.bmcl.2009.07.136
	45485725	197827	None	0	Human	Functional	pEC50	=	7.6	7.6	2	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	CHEMBL572252	197827	None	0	Human	Functional	pEC50	=	7.6	7.6	2	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	53321948	56804	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643677	56804	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	137661221	159399	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	286	2	0	4	3.7	Cn1nc(-c2cccc3ccccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	CHEMBL4100745	159399	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	286	2	0	4	3.7	Cn1nc(-c2cccc3ccccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	122442293	138342	None	0	Human	Functional	pEC50	=	7.6	7.6	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138342	None	0	Human	Functional	pEC50	=	7.6	7.6	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138342	None	0	Human	Functional	pEC50	=	7.6	7.6	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	72197486	102503	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	8	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393245	102503	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	8	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040361	102503	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	8	Antagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assayAntagonist activity at serotonin-activated human recombinant 5HT-2C receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	146025689	183717	None	0	Human	Functional	pEC50	=	7.6	7.6	17	2	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4781163	183717	None	0	Human	Functional	pEC50	=	7.6	7.6	17	2	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803350	183717	None	0	Human	Functional	pEC50	=	7.6	7.6	17	2	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	162653458	183666	None	0	Human	Functional	pEC50	=	7.6	7.6	6	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183666	None	0	Human	Functional	pEC50	=	7.6	7.6	6	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183666	None	0	Human	Functional	pEC50	=	7.6	7.6	6	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	5	139	None	72	Human	Functional	pEC50	=	7.6	7.6	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	5202	139	None	72	Human	Functional	pEC50	=	7.6	7.6	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	7.6	7.6	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	DB08839	139	None	72	Human	Functional	pEC50	=	7.6	7.6	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	216	2860	None	32	Human	Functional	pEC50	=	7.6	7.6	-1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	9815618	2860	None	32	Human	Functional	pEC50	=	7.6	7.6	-1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	CHEMBL253811	2860	None	32	Human	Functional	pEC50	=	7.6	7.6	-1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	22292784	64594	None	15	Human	Functional	pEC50	=	7.6	7.6	5	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	CHEMBL181672	64594	None	15	Human	Functional	pEC50	=	7.6	7.6	5	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	122442293	138342	None	0	Human	Functional	pEC50	=	7.6	7.6	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138342	None	0	Human	Functional	pEC50	=	7.6	7.6	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138342	None	0	Human	Functional	pEC50	=	7.6	7.6	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	132820207	147912	None	0	Human	Functional	pEC50	=	7.6	7.6	25	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	220	0	1	2	1.9	Fc1ccc2c(c1)CC[C@@H]1CNCCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3933563	147912	None	0	Human	Functional	pEC50	=	7.6	7.6	25	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	220	0	1	2	1.9	Fc1ccc2c(c1)CC[C@@H]1CNCCCN21	10.1016/j.bmcl.2016.11.016
	134155579	151331	None	0	Human	Functional	pEC50	=	7.6	7.6	3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	250	0	1	2	2.8	Clc1cccc2c1N1CCCNCCC1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3961026	151331	None	0	Human	Functional	pEC50	=	7.6	7.6	3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	250	0	1	2	2.8	Clc1cccc2c1N1CCCNCCC1CC2	10.1016/j.bmcl.2016.11.016
	162676555	183789	None	0	Human	Functional	pEC50	=	7.6	7.6	22	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4800666	183789	None	0	Human	Functional	pEC50	=	7.6	7.6	22	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804119	183789	None	0	Human	Functional	pEC50	=	7.6	7.6	22	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	118733778	120660	None	0	Human	Functional	pEC50	=	6.6	6.6	19	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3416041	120660	None	0	Human	Functional	pEC50	=	6.6	6.6	19	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3546951	120660	None	0	Human	Functional	pEC50	=	6.6	6.6	19	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	68803474	153017	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	218	1	1	3	1.4	COc1ccc2c(c1)CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3975593	153017	None	0	Human	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	218	1	1	3	1.4	COc1ccc2c(c1)CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	3045239	79573	None	2	Rat	Functional	pEC50	=	6.6	6.6	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	242	3	1	3	2.4	COc1ccc2c(c1)-c1c(ccn1C[C@H](C)N)C2	10.1021/jm970030l
	CHEMBL2114265	79573	None	2	Rat	Functional	pEC50	=	6.6	6.6	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	242	3	1	3	2.4	COc1ccc2c(c1)-c1c(ccn1C[C@H](C)N)C2	10.1021/jm970030l
	10487869	107357	None	3	Rat	Functional	pEC50	=	5.6	5.6	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	188	2	1	2	2.3	Cc1cccc2c1ccn2CC(C)N	10.1021/jm970030l
	CHEMBL317677	107357	None	3	Rat	Functional	pEC50	=	5.6	5.6	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	188	2	1	2	2.3	Cc1cccc2c1ccn2CC(C)N	10.1021/jm970030l
	19036385	108543	None	0	Rat	Functional	pEC50	=	5.6	5.6	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	290	2	1	2	3.2	CC(N)Cn1ccc2c1-c1cc(Br)ccc1C2	10.1021/jm970030l
	CHEMBL320145	108543	None	0	Rat	Functional	pEC50	=	5.6	5.6	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	290	2	1	2	3.2	CC(N)Cn1ccc2c1-c1cc(Br)ccc1C2	10.1021/jm970030l
	19036374	207079	None	0	Rat	Functional	pEC50	=	5.6	5.6	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	246	2	1	2	3.1	CC(N)Cn1ccc2c1-c1cc(Cl)ccc1C2	10.1021/jm970030l
	CHEMBL91855	207079	None	0	Rat	Functional	pEC50	=	5.6	5.6	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	246	2	1	2	3.1	CC(N)Cn1ccc2c1-c1cc(Cl)ccc1C2	10.1021/jm970030l
	10845306	207388	None	0	Rat	Functional	pEC50	=	5.6	5.6	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	188	2	1	2	2.3	Cc1ccc2c(ccn2CC(C)N)c1	10.1021/jm970030l
	CHEMBL93850	207388	None	0	Rat	Functional	pEC50	=	5.6	5.6	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	188	2	1	2	2.3	Cc1ccc2c(ccn2CC(C)N)c1	10.1021/jm970030l
	70681342	74468	None	1	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	219	5	1	2	2.8	CC(C)COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022187	74468	None	1	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	219	5	1	2	2.8	CC(C)COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027941	74468	None	1	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	219	5	1	2	2.8	CC(C)COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	154703875	176448	None	1	Human	Functional	pEC50	=	5.6	5.6	-6	2	Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assayAgonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4586582	176448	None	1	Human	Functional	pEC50	=	5.6	5.6	-6	2	Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assayAgonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4596341	176448	None	1	Human	Functional	pEC50	=	5.6	5.6	-6	2	Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assayAgonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	137630172	161054	None	0	Human	Functional	pEC50	=	5.6	5.6	-10	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	7	1	3	4.3	COc1ccccc1C(C)NCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4066538	161054	None	0	Human	Functional	pEC50	=	5.6	5.6	-10	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	7	1	3	4.3	COc1ccccc1C(C)NCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4116576	161054	None	0	Human	Functional	pEC50	=	5.6	5.6	-10	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	7	1	3	4.3	COc1ccccc1C(C)NCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4802921	214067	None	2	Human	Functional	pEC50	=	6.6	6.6	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802921	214067	None	2	Human	Functional	pEC50	=	6.6	6.6	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	137630172	161054	None	0	Human	Functional	pEC50	=	5.6	5.6	-10	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	7	1	3	4.3	COc1ccccc1C(C)NCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4066538	161054	None	0	Human	Functional	pEC50	=	5.6	5.6	-10	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	7	1	3	4.3	COc1ccccc1C(C)NCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4116576	161054	None	0	Human	Functional	pEC50	=	5.6	5.6	-10	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	7	1	3	4.3	COc1ccccc1C(C)NCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	11448649	83433	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL219734	83433	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	11716185	89064	None	0	Human	Functional	pEC50	=	7.6	7.6	70	2	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337497	89064	None	0	Human	Functional	pEC50	=	7.6	7.6	70	2	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2364998	89064	None	0	Human	Functional	pEC50	=	7.6	7.6	70	2	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	146025684	183635	None	0	Human	Functional	pEC50	=	7.6	7.6	6	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183635	None	0	Human	Functional	pEC50	=	7.6	7.6	6	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183635	None	0	Human	Functional	pEC50	=	7.6	7.6	6	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162658153	183685	None	0	Human	Functional	pEC50	=	7.6	7.6	10	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183685	None	0	Human	Functional	pEC50	=	7.6	7.6	10	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183685	None	0	Human	Functional	pEC50	=	7.6	7.6	10	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	162676555	183789	None	0	Human	Functional	pEC50	=	7.6	7.6	22	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4800666	183789	None	0	Human	Functional	pEC50	=	7.6	7.6	22	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804119	183789	None	0	Human	Functional	pEC50	=	7.6	7.6	22	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	44572759	12462	None	1	Human	Functional	pEC50	=	7.6	7.6	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186135	12462	None	1	Human	Functional	pEC50	=	7.6	7.6	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL451368	12462	None	1	Human	Functional	pEC50	=	7.6	7.6	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	45484945	198490	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	326	4	1	5	1.7	Cc1ccccc1CCc1nc(N2CCNC[C@H]2C)cc(=O)n1C	10.1016/j.bmcl.2009.07.133
	CHEMBL577690	198490	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	326	4	1	5	1.7	Cc1ccccc1CCc1nc(N2CCNC[C@H]2C)cc(=O)n1C	10.1016/j.bmcl.2009.07.133
	45484903	198779	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	346	4	1	5	2.0	C[C@@H]1CNCCN1c1cc(=O)n(C)c(CCc2cccc(Cl)c2)n1	10.1016/j.bmcl.2009.07.133
	CHEMBL583193	198779	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	346	4	1	5	2.0	C[C@@H]1CNCCN1c1cc(=O)n(C)c(CCc2cccc(Cl)c2)n1	10.1016/j.bmcl.2009.07.133
	45484700	197303	None	0	Human	Functional	pEC50	=	7.6	7.6	3	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	295	3	1	4	1.9	O=c1cc2c(nn1Cc1ccc(C3CC3)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL568692	197303	None	0	Human	Functional	pEC50	=	7.6	7.6	3	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	295	3	1	4	1.9	O=c1cc2c(nn1Cc1ccc(C3CC3)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	1355	2011	None	88	Human	Functional	pEC50	=	7.6	7.6	4	6	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	142	2011	None	88	Human	Functional	pEC50	=	7.6	7.6	4	6	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	CHEMBL478	2011	None	88	Human	Functional	pEC50	=	7.6	7.6	4	6	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	DB12110	2011	None	88	Human	Functional	pEC50	=	7.6	7.6	4	6	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	44315993	172877	None	0	Human	Functional	pEC50	=	7.6	7.6	-2	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL451543	172877	None	0	Human	Functional	pEC50	=	7.6	7.6	-2	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	146025684	183635	None	0	Human	Functional	pEC50	=	7.6	7.6	6	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183635	None	0	Human	Functional	pEC50	=	7.6	7.6	6	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183635	None	0	Human	Functional	pEC50	=	7.6	7.6	6	3	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162658153	183685	None	0	Human	Functional	pEC50	=	7.6	7.6	10	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183685	None	0	Human	Functional	pEC50	=	7.6	7.6	10	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183685	None	0	Human	Functional	pEC50	=	7.6	7.6	10	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	46228442	199903	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	360	4	1	6	3.3	Clc1cccc(COc2nc(N3CCNCC3)nc3ccsc23)c1	10.1016/j.bmcl.2009.10.112
	CHEMBL594718	199903	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	360	4	1	6	3.3	Clc1cccc(COc2nc(N3CCNCC3)nc3ccsc23)c1	10.1016/j.bmcl.2009.10.112
	137630777	161108	None	0	Human	Functional	pEC50	=	5.6	5.6	2	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1cccc(CNC[C@@H]2C[C@H]2c2cc(F)ccc2OC)c1	10.1021/acs.jmedchem.7b00584
	CHEMBL4093447	161108	None	0	Human	Functional	pEC50	=	5.6	5.6	2	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1cccc(CNC[C@@H]2C[C@H]2c2cc(F)ccc2OC)c1	10.1021/acs.jmedchem.7b00584
	CHEMBL4117067	161108	None	0	Human	Functional	pEC50	=	5.6	5.6	2	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1cccc(CNC[C@@H]2C[C@H]2c2cc(F)ccc2OC)c1	10.1021/acs.jmedchem.7b00584
	12986497	200128	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	305	0	2	3	2.1	O=C1Nc2cc(C(F)(F)F)c(Cl)cc2N2CCNC[C@@H]12	10.1016/s0960-894x(00)00400-5
	CHEMBL59619	200128	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	305	0	2	3	2.1	O=C1Nc2cc(C(F)(F)F)c(Cl)cc2N2CCNC[C@@H]12	10.1016/s0960-894x(00)00400-5
	162660358	183704	None	0	Human	Functional	pEC50	=	6.6	6.6	2	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762722	183704	None	0	Human	Functional	pEC50	=	6.6	6.6	2	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803207	183704	None	0	Human	Functional	pEC50	=	6.6	6.6	2	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	6604933	95754	None	16	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	226	0	1	2	2.6	c1cc2c3c(c1)c1c(n3CCNC2)CCCC1	10.1021/jm801354e
	CHEMBL258465	95754	None	16	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	226	0	1	2	2.6	c1cc2c3c(c1)c1c(n3CCNC2)CCCC1	10.1021/jm801354e
	45484833	196833	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	362	6	1	6	2.1	Cc1cc(=O)n(CCCOc2cccc(Cl)c2)c(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.133
	CHEMBL565764	196833	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	362	6	1	6	2.1	Cc1cc(=O)n(CCCOc2cccc(Cl)c2)c(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.133
	45484902	198635	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	312	4	1	5	1.4	C[C@@H]1CNCCN1c1cc(=O)n(C)c(CCc2ccccc2)n1	10.1016/j.bmcl.2009.07.133
	CHEMBL579042	198635	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	312	4	1	5	1.4	C[C@@H]1CNCCN1c1cc(=O)n(C)c(CCc2ccccc2)n1	10.1016/j.bmcl.2009.07.133
	162660358	183704	None	0	Human	Functional	pEC50	=	6.6	6.6	2	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762722	183704	None	0	Human	Functional	pEC50	=	6.6	6.6	2	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803207	183704	None	0	Human	Functional	pEC50	=	6.6	6.6	2	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	137630777	161108	None	0	Human	Functional	pEC50	=	5.6	5.6	2	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1cccc(CNC[C@@H]2C[C@H]2c2cc(F)ccc2OC)c1	10.1021/acs.jmedchem.7b00584
	CHEMBL4093447	161108	None	0	Human	Functional	pEC50	=	5.6	5.6	2	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1cccc(CNC[C@@H]2C[C@H]2c2cc(F)ccc2OC)c1	10.1021/acs.jmedchem.7b00584
	CHEMBL4117067	161108	None	0	Human	Functional	pEC50	=	5.6	5.6	2	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	315	7	1	3	3.7	COc1cccc(CNC[C@@H]2C[C@H]2c2cc(F)ccc2OC)c1	10.1021/acs.jmedchem.7b00584
	3568128	192933	None	1	Human	Functional	pEC50	=	5.6	5.6	-6	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	192933	None	1	Human	Functional	pEC50	=	5.6	5.6	-6	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	192933	None	1	Human	Functional	pEC50	=	5.6	5.6	-6	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	3568128	192933	None	1	Human	Functional	pEC50	=	5.6	5.6	-6	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	192933	None	1	Human	Functional	pEC50	=	5.6	5.6	-6	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	192933	None	1	Human	Functional	pEC50	=	5.6	5.6	-6	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	73417116	154431	None	0	Human	Functional	pEC50	=	5.6	5.6	-4	5	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	266	2	2	2	3.0	N[C@@H]1C[C@H]1c1ccccc1.N[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL3989843	154431	None	0	Human	Functional	pEC50	=	5.6	5.6	-4	5	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	266	2	2	2	3.0	N[C@@H]1C[C@H]1c1ccccc1.N[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	57799326	89108	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	242	1	2	2	1.7	Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337104	89108	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	242	1	2	2	1.7	Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365468	89108	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	242	1	2	2	1.7	Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	137655882	158757	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	302	3	0	4	4.1	CCn1nc(-c2cccc3ccccc23)cc1-c1nccn1C	10.1021/acs.jmedchem.7b00385
	CHEMBL4093978	158757	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	302	3	0	4	4.1	CCn1nc(-c2cccc3ccccc23)cc1-c1nccn1C	10.1021/acs.jmedchem.7b00385
	44573227	187191	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	420	4	1	4	3.3	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2cccc(Cl)c2)CC1	10.1016/j.bmcl.2009.02.071
	CHEMBL492302	187191	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	420	4	1	4	3.3	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2cccc(Cl)c2)CC1	10.1016/j.bmcl.2009.02.071
	45484869	197213	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	298	4	1	5	1.0	Cn1c(CCc2ccccc2)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	CHEMBL568236	197213	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	298	4	1	5	1.0	Cn1c(CCc2ccccc2)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	122442273	138356	None	0	Human	Functional	pEC50	=	6.6	6.6	1	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138356	None	0	Human	Functional	pEC50	=	6.6	6.6	1	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138356	None	0	Human	Functional	pEC50	=	6.6	6.6	1	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442273	138356	None	0	Human	Functional	pEC50	=	6.6	6.6	1	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138356	None	0	Human	Functional	pEC50	=	6.6	6.6	1	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138356	None	0	Human	Functional	pEC50	=	6.6	6.6	1	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	137636430	156048	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	338	2	0	4	3.7	Cc1sc(-c2cccc3ccccc23)nc1C(=O)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4062529	156048	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	338	2	0	4	3.7	Cc1sc(-c2cccc3ccccc23)nc1C(=O)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	16115381	83443	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL219837	83443	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	58911534	91109	None	0	Human	Functional	pEC50	=	7.6	7.6	7	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397904	91109	None	0	Human	Functional	pEC50	=	7.6	7.6	7	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	137630892	161125	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	347	9	1	3	4.1	COc1ccc(F)cc1C1CC1CNCc1ccccc1OCCF	10.1021/acs.jmedchem.7b00584
	CHEMBL4086286	161125	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	347	9	1	3	4.1	COc1ccc(F)cc1C1CC1CNCc1ccccc1OCCF	10.1021/acs.jmedchem.7b00584
	CHEMBL4117192	161125	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	347	9	1	3	4.1	COc1ccc(F)cc1C1CC1CNCc1ccccc1OCCF	10.1021/acs.jmedchem.7b00584
	107992	2553	None	49	Human	Functional	pEC50	=	7.6	7.6	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	165	2553	None	49	Human	Functional	pEC50	=	7.6	7.6	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	CHEMBL269521	2553	None	49	Human	Functional	pEC50	=	7.6	7.6	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	DB12111	2553	None	49	Human	Functional	pEC50	=	7.6	7.6	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	44573161	193216	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	392	4	1	4	2.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CC(Oc2ccc(Cl)cc2)C1	10.1016/j.bmcl.2009.02.071
	CHEMBL523521	193216	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	392	4	1	4	2.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CC(Oc2ccc(Cl)cc2)C1	10.1016/j.bmcl.2009.02.071
	10401602	123069	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360968	123069	None	0	Human	Functional	pEC50	=	7.6	7.6	3	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	9881119	205473	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL80482	205473	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	137630892	161125	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	347	9	1	3	4.1	COc1ccc(F)cc1C1CC1CNCc1ccccc1OCCF	10.1021/acs.jmedchem.7b00584
	CHEMBL4086286	161125	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	347	9	1	3	4.1	COc1ccc(F)cc1C1CC1CNCc1ccccc1OCCF	10.1021/acs.jmedchem.7b00584
	CHEMBL4117192	161125	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	347	9	1	3	4.1	COc1ccc(F)cc1C1CC1CNCc1ccccc1OCCF	10.1021/acs.jmedchem.7b00584
	107992	2553	None	49	Human	Functional	pEC50	=	7.6	7.6	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	165	2553	None	49	Human	Functional	pEC50	=	7.6	7.6	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	CHEMBL269521	2553	None	49	Human	Functional	pEC50	=	7.6	7.6	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	DB12111	2553	None	49	Human	Functional	pEC50	=	7.6	7.6	6	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	10.1021/jm301656h
	168295069	193027	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	317	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccncc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5208635	193027	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	317	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccncc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5222843	193027	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	317	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccncc1Cl	10.1021/acsmedchemlett.1c00694
	11288140	84769	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	213	0	1	3	0.7	N#Cc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL223090	84769	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	213	0	1	3	0.7	N#Cc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	162644225	183621	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777891	183621	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802348	183621	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	4646586	193013	None	2	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5209080	193013	None	2	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222774	193013	None	2	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168295069	193027	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	317	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccncc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5208635	193027	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	317	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccncc1Cl	10.1021/acsmedchemlett.1c00694
	CHEMBL5222843	193027	None	0	Human	Functional	pEC50	=	5.6	5.6	-3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	317	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccncc1Cl	10.1021/acsmedchemlett.1c00694
	162644225	183621	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777891	183621	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802348	183621	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	4646586	193013	None	2	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5209080	193013	None	2	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222774	193013	None	2	Human	Functional	pEC50	=	6.6	6.6	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	2	2	4.1	COc1ccccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	118733770	120647	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	253	6	1	2	3.6	CCCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416037	120647	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	253	6	1	2	3.6	CCCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546892	120647	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	253	6	1	2	3.6	CCCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	155548667	176373	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	179	3	1	1	2.1	CNC[C@H]1C[C@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	CHEMBL4537637	176373	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	179	3	1	1	2.1	CNC[C@H]1C[C@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	CHEMBL4595810	176373	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	179	3	1	1	2.1	CNC[C@H]1C[C@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	44572747	12705	None	2	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	CHEMBL1187580	12705	None	2	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	CHEMBL510308	12705	None	2	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	168268706	192757	None	0	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170614	192757	None	0	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221142	192757	None	0	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	12986493	202018	None	1	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNC[C@@H]12	10.1016/s0960-894x(00)00400-5
	CHEMBL60830	202018	None	1	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNC[C@@H]12	10.1016/s0960-894x(00)00400-5
	44572698	12552	None	0	Human	Functional	pEC50	=	5.5	5.5	-5	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	CHEMBL1186700	12552	None	0	Human	Functional	pEC50	=	5.5	5.5	-5	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	CHEMBL474885	12552	None	0	Human	Functional	pEC50	=	5.5	5.5	-5	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	137656030	158642	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2nccc3ccccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	CHEMBL4092473	158642	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2nccc3ccccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	155548667	176373	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	179	3	1	1	2.1	CNC[C@H]1C[C@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	CHEMBL4537637	176373	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	179	3	1	1	2.1	CNC[C@H]1C[C@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	CHEMBL4595810	176373	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	179	3	1	1	2.1	CNC[C@H]1C[C@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	45484726	198403	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	257	2	1	4	0.9	Cn1c2c(c(=O)n1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL576912	198403	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	257	2	1	4	0.9	Cn1c2c(c(=O)n1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	168289654	192959	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5193914	192959	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222453	192959	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	168280142	192861	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5183068	192861	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221869	192861	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	168280142	192861	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5183068	192861	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221869	192861	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	290	1	2	2	3.4	Clc1ccc2[nH]c3c(c2c1)CCNC3C1CCOCC1	10.1021/acsmedchemlett.1c00694
	168289654	192959	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5193914	192959	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222453	192959	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	270	1	3	3	3.2	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	20026449	87306	None	1	Human	Functional	pEC50	=	5.5	5.5	2	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	182	2	1	4	0.8	CCOc1noc2c1CCNCC2	10.1021/jm301656h
	CHEMBL2331793	87306	None	1	Human	Functional	pEC50	=	5.5	5.5	2	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	182	2	1	4	0.8	CCOc1noc2c1CCNCC2	10.1021/jm301656h
	146464686	191997	None	0	Human	Functional	pEC50	=	5.5	5.5	-8	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	3	4	1.9	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201492	191997	None	0	Human	Functional	pEC50	=	5.5	5.5	-8	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	266	1	3	4	1.9	Oc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	44420682	137608	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	CHEMBL375642	137608	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	118733816	120659	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416060	120659	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546911	120659	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	11313985	91083	None	0	Human	Functional	pEC50	=	8.5	8.5	15	3	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397878	91083	None	0	Human	Functional	pEC50	=	8.5	8.5	15	3	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	11206703	91092	None	0	Human	Functional	pEC50	=	8.5	8.5	12	3	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397887	91092	None	0	Human	Functional	pEC50	=	8.5	8.5	12	3	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	44572166	12460	None	0	Human	Functional	pEC50	=	8.5	8.5	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL1186133	12460	None	0	Human	Functional	pEC50	=	8.5	8.5	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL451232	12460	None	0	Human	Functional	pEC50	=	8.5	8.5	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	155532108	176566	None	0	Human	Functional	pEC50	=	8.5	8.5	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@]1(F)c1cccc(F)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4466591	176566	None	0	Human	Functional	pEC50	=	8.5	8.5	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@]1(F)c1cccc(F)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4597360	176566	None	0	Human	Functional	pEC50	=	8.5	8.5	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@]1(F)c1cccc(F)c1	10.1016/j.ejmech.2019.111626
	11777150	62605	None	0	Human	Functional	pEC50	=	8.5	8.5	20	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178313	62605	None	0	Human	Functional	pEC50	=	8.5	8.5	20	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	44389645	64181	None	0	Human	Functional	pEC50	=	8.5	8.5	26	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180867	64181	None	0	Human	Functional	pEC50	=	8.5	8.5	26	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	11608308	64309	None	4	Human	Functional	pEC50	=	8.5	8.5	42	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL181076	64309	None	4	Human	Functional	pEC50	=	8.5	8.5	42	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	36906	104880	None	75	Rat	Functional	pEC50	=	8.5	8.5	-1	3	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	CHEMBL31115	104880	None	75	Rat	Functional	pEC50	=	8.5	8.5	-1	3	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	162656505	180904	None	0	Human	Functional	pEC50	=	8.5	8.5	316	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	284	2	1	2	2.9	FC(F)(F)CCc1cccc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	CHEMBL4757718	180904	None	0	Human	Functional	pEC50	=	8.5	8.5	316	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	284	2	1	2	2.9	FC(F)(F)CCc1cccc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	11608308	64309	None	4	Human	Functional	pEC50	=	8.5	8.5	42	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL181076	64309	None	4	Human	Functional	pEC50	=	8.5	8.5	42	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	122442270	138346	None	1	Human	Functional	pEC50	=	8.5	8.5	6	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138346	None	1	Human	Functional	pEC50	=	8.5	8.5	6	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138346	None	1	Human	Functional	pEC50	=	8.5	8.5	6	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442251	138360	None	0	Human	Functional	pEC50	=	8.5	8.5	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138360	None	0	Human	Functional	pEC50	=	8.5	8.5	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138360	None	0	Human	Functional	pEC50	=	8.5	8.5	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	134142903	145240	None	0	Human	Functional	pEC50	=	8.5	8.5	630	3	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	256	2	1	2	2.8	c1cc(CC2CCC2)c2c(c1)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3912721	145240	None	0	Human	Functional	pEC50	=	8.5	8.5	630	3	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	256	2	1	2	2.8	c1cc(CC2CCC2)c2c(c1)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	83753960	150696	None	0	Human	Functional	pEC50	=	8.5	8.5	39	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	206	0	1	2	1.6	Fc1ccc2c(c1)CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3955996	150696	None	0	Human	Functional	pEC50	=	8.5	8.5	39	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	206	0	1	2	1.6	Fc1ccc2c(c1)CCC1CNCCN21	10.1016/j.bmcl.2016.11.016
	134156657	153833	None	0	Human	Functional	pEC50	=	8.5	8.5	12	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	242	1	1	2	2.7	c1cc(C2CCC2)c2c(c1)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3982618	153833	None	0	Human	Functional	pEC50	=	8.5	8.5	12	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	242	1	1	2	2.7	c1cc(C2CCC2)c2c(c1)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	122442251	138360	None	0	Human	Functional	pEC50	=	8.5	8.5	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138360	None	0	Human	Functional	pEC50	=	8.5	8.5	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138360	None	0	Human	Functional	pEC50	=	8.5	8.5	15	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11652452	89126	None	0	Human	Functional	pEC50	=	8.5	8.5	9	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337492	89126	None	0	Human	Functional	pEC50	=	8.5	8.5	9	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365703	89126	None	0	Human	Functional	pEC50	=	8.5	8.5	9	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	11609026	89127	None	0	Human	Functional	pEC50	=	8.5	8.5	38	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337500	89127	None	0	Human	Functional	pEC50	=	8.5	8.5	38	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365705	89127	None	0	Human	Functional	pEC50	=	8.5	8.5	38	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	44572798	12650	None	2	Human	Functional	pEC50	=	8.5	8.5	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL1187187	12650	None	2	Human	Functional	pEC50	=	8.5	8.5	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL492926	12650	None	2	Human	Functional	pEC50	=	8.5	8.5	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	44572808	12706	None	0	Human	Functional	pEC50	=	8.5	8.5	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL1187585	12706	None	0	Human	Functional	pEC50	=	8.5	8.5	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL510383	12706	None	0	Human	Functional	pEC50	=	8.5	8.5	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	11949710	199902	None	0	Human	Functional	pEC50	=	8.5	8.5	50	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594717	199902	None	0	Human	Functional	pEC50	=	8.5	8.5	50	3	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	11658860	2344	None	51	Human	Functional	pEC50	=	8.5	8.5	1	11	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2344	None	51	Human	Functional	pEC50	=	8.5	8.5	1	11	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2344	None	51	Human	Functional	pEC50	=	8.5	8.5	1	11	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.5	8.5	1	11	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.5	8.5	1	11	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	92042921	120670	None	0	Human	Functional	pEC50	=	8.5	8.5	104	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416067	120670	None	0	Human	Functional	pEC50	=	8.5	8.5	104	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546961	120670	None	0	Human	Functional	pEC50	=	8.5	8.5	104	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	122442270	138346	None	1	Human	Functional	pEC50	=	8.5	8.5	6	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138346	None	1	Human	Functional	pEC50	=	8.5	8.5	6	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138346	None	1	Human	Functional	pEC50	=	8.5	8.5	6	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11658860	2344	None	51	Human	Functional	pEC50	=	8.5	8.5	1	11	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2344	None	51	Human	Functional	pEC50	=	8.5	8.5	1	11	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2344	None	51	Human	Functional	pEC50	=	8.5	8.5	1	11	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.5	8.5	1	11	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.5	8.5	1	11	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	44572174	12547	None	0	Human	Functional	pEC50	=	8.5	8.5	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186687	12547	None	0	Human	Functional	pEC50	=	8.5	8.5	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL474634	12547	None	0	Human	Functional	pEC50	=	8.5	8.5	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	11658860	2344	None	51	Human	Functional	pEC50	=	8.4	8.4	1	11	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	2941	2344	None	51	Human	Functional	pEC50	=	8.4	8.4	1	11	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	4374	2344	None	51	Human	Functional	pEC50	=	8.4	8.4	1	11	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.4	8.4	1	11	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.4	8.4	1	11	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	135453290	133606	None	33	Rat	Functional	pEC50	=	8.4	8.4	-1	7	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL371300	133606	None	33	Rat	Functional	pEC50	=	8.4	8.4	-1	7	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	122442286	138351	None	0	Human	Functional	pEC50	=	8.4	8.4	13	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138351	None	0	Human	Functional	pEC50	=	8.4	8.4	13	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138351	None	0	Human	Functional	pEC50	=	8.4	8.4	13	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442286	138351	None	0	Human	Functional	pEC50	=	8.4	8.4	13	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138351	None	0	Human	Functional	pEC50	=	8.4	8.4	13	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138351	None	0	Human	Functional	pEC50	=	8.4	8.4	13	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	166	3359	None	18	Human	Functional	pEC50	=	8.4	8.4	-2	4	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	3045227	3359	None	18	Human	Functional	pEC50	=	8.4	8.4	-2	4	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	CHEMBL76781	3359	None	18	Human	Functional	pEC50	=	8.4	8.4	-2	4	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	9991444	62632	None	1	Human	Functional	pEC50	=	8.4	8.4	4	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL178366	62632	None	1	Human	Functional	pEC50	=	8.4	8.4	4	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	24773649	94827	None	0	Human	Functional	pEC50	=	8.4	8.4	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253591	94827	None	0	Human	Functional	pEC50	=	8.4	8.4	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	24773897	94858	None	3	Human	Functional	pEC50	=	8.4	8.4	251	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	C[C@@H]1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	CHEMBL253807	94858	None	3	Human	Functional	pEC50	=	8.4	8.4	251	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	C[C@@H]1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	134137343	143067	None	0	Human	Functional	pEC50	=	8.4	8.4	15	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	266	1	1	3	2.5	COc1cc2c(cc1Cl)CC[C@@H]1CNCCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3895184	143067	None	0	Human	Functional	pEC50	=	8.4	8.4	15	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	266	1	1	3	2.5	COc1cc2c(cc1Cl)CC[C@@H]1CNCCCN21	10.1016/j.bmcl.2016.11.016
	11587397	89056	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337489	89056	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364893	89056	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	44572804	12623	None	1	Human	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL1187088	12623	None	1	Human	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL490064	12623	None	1	Human	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	45484858	198576	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	368	4	1	6	1.8	Cn1c(COc2ccccc2C(F)(F)F)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	CHEMBL578364	198576	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	368	4	1	6	1.8	Cn1c(COc2ccccc2C(F)(F)F)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	45484662	198491	None	0	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1cccc(Cl)c1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL577691	198491	None	0	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1cccc(Cl)c1)CCNCC2	10.1016/j.bmcl.2009.07.063
	137647004	157842	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	326	4	1	4	3.3	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N(C)CCO	10.1021/acs.jmedchem.7b00385
	CHEMBL4083671	157842	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	326	4	1	4	3.3	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N(C)CCO	10.1021/acs.jmedchem.7b00385
	44622848	193347	None	0	Human	Functional	pEC50	=	7.5	7.5	11	2	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	255	2	1	4	1.0	O=c1cc2c(nn1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2016.06.060
	CHEMBL524778	193347	None	0	Human	Functional	pEC50	=	7.5	7.5	11	2	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	255	2	1	4	1.0	O=c1cc2c(nn1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2016.06.060
	122442270	138346	None	1	Human	Functional	pEC50	=	7.5	7.5	6	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138346	None	1	Human	Functional	pEC50	=	7.5	7.5	6	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138346	None	1	Human	Functional	pEC50	=	7.5	7.5	6	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11291	3220	None	26	Human	Functional	pEC50	=	7.5	7.5	-1	4	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	4980	3220	None	26	Human	Functional	pEC50	=	7.5	7.5	-1	4	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	CHEMBL65547	3220	None	26	Human	Functional	pEC50	=	7.5	7.5	-1	4	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	157	2069	None	7	Rat	Functional	pEC50	=	7.5	7.5	-2	3	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	9840090	2069	None	7	Rat	Functional	pEC50	=	7.5	7.5	-2	3	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	CHEMBL134519	2069	None	7	Rat	Functional	pEC50	=	7.5	7.5	-2	3	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	157	2069	None	7	Rat	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	9840090	2069	None	7	Rat	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	CHEMBL134519	2069	None	7	Rat	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	168268706	192757	None	0	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170614	192757	None	0	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221142	192757	None	0	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1	10.1021/acsmedchemlett.1c00694
	54585653	61465	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	307	2	1	3	2.8	FC(F)(F)c1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770385	61465	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	307	2	1	3	2.8	FC(F)(F)c1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	20026449	87306	None	1	Human	Functional	pEC50	=	5.5	5.5	2	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	182	2	1	4	0.8	CCOc1noc2c1CCNCC2	10.1021/jm301656h
	CHEMBL2331793	87306	None	1	Human	Functional	pEC50	=	5.5	5.5	2	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	182	2	1	4	0.8	CCOc1noc2c1CCNCC2	10.1021/jm301656h
	44572252	12551	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	241	3	1	1	3.6	NC[C@H]1C[C@@H]1c1ccccc1-c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL1186699	12551	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	241	3	1	1	3.6	NC[C@H]1C[C@@H]1c1ccccc1-c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL474860	12551	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	241	3	1	1	3.6	NC[C@H]1C[C@@H]1c1ccccc1-c1ccc(F)cc1	10.1021/jm801354e
	12370466	12432	None	1	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL1185943	12432	None	1	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL442657	12432	None	1	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	162656326	183677	None	0	Human	Functional	pEC50	=	6.5	6.5	6	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4757142	183677	None	0	Human	Functional	pEC50	=	6.5	6.5	6	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802987	183677	None	0	Human	Functional	pEC50	=	6.5	6.5	6	2	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	137629241	161000	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	301	6	2	3	3.4	COc1ccc(F)cc1C1CC1CNCc1ccccc1O	10.1021/acs.jmedchem.7b00584
	CHEMBL4102683	161000	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	301	6	2	3	3.4	COc1ccc(F)cc1C1CC1CNCc1ccccc1O	10.1021/acs.jmedchem.7b00584
	CHEMBL4116193	161000	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	301	6	2	3	3.4	COc1ccc(F)cc1C1CC1CNCc1ccccc1O	10.1021/acs.jmedchem.7b00584
	137629241	161000	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	301	6	2	3	3.4	COc1ccc(F)cc1C1CC1CNCc1ccccc1O	10.1021/acs.jmedchem.7b00584
	CHEMBL4102683	161000	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	301	6	2	3	3.4	COc1ccc(F)cc1C1CC1CNCc1ccccc1O	10.1021/acs.jmedchem.7b00584
	CHEMBL4116193	161000	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	301	6	2	3	3.4	COc1ccc(F)cc1C1CC1CNCc1ccccc1O	10.1021/acs.jmedchem.7b00584
	70693928	74485	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	CHEMBL2022192	74485	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	CHEMBL2028036	74485	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	3568612	192995	None	2	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5203138	192995	None	2	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222646	192995	None	2	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	137629785	161186	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	291	6	1	3	3.8	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1cccs1	10.1021/acs.jmedchem.7b00584
	CHEMBL4095562	161186	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	291	6	1	3	3.8	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1cccs1	10.1021/acs.jmedchem.7b00584
	CHEMBL4117659	161186	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	291	6	1	3	3.8	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1cccs1	10.1021/acs.jmedchem.7b00584
	122442324	138350	None	0	Human	Functional	pEC50	=	6.5	6.5	12	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138350	None	0	Human	Functional	pEC50	=	6.5	6.5	12	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138350	None	0	Human	Functional	pEC50	=	6.5	6.5	12	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	137629785	161186	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	291	6	1	3	3.8	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1cccs1	10.1021/acs.jmedchem.7b00584
	CHEMBL4095562	161186	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	291	6	1	3	3.8	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1cccs1	10.1021/acs.jmedchem.7b00584
	CHEMBL4117659	161186	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	291	6	1	3	3.8	COc1ccc(F)cc1[C@@H]1C[C@H]1CNCc1cccs1	10.1021/acs.jmedchem.7b00584
	3568612	192995	None	2	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5203138	192995	None	2	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222646	192995	None	2	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	280	1	2	1	3.9	Cc1cccc(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	122442324	138350	None	0	Human	Functional	pEC50	=	6.5	6.5	12	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138350	None	0	Human	Functional	pEC50	=	6.5	6.5	12	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138350	None	0	Human	Functional	pEC50	=	6.5	6.5	12	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	155534560	176421	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	2	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	243	2	1	1	2.6	NC[C@H]1C[C@]1(F)c1ccccc1Br	10.1016/j.ejmech.2019.111626
	CHEMBL4470610	176421	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	2	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	243	2	1	1	2.6	NC[C@H]1C[C@]1(F)c1ccccc1Br	10.1016/j.ejmech.2019.111626
	CHEMBL4596162	176421	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	2	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	243	2	1	1	2.6	NC[C@H]1C[C@]1(F)c1ccccc1Br	10.1016/j.ejmech.2019.111626
	44622848	193347	None	0	Human	Functional	pEC50	=	7.5	7.5	11	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	255	2	1	4	1.0	O=c1cc2c(nn1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL524778	193347	None	0	Human	Functional	pEC50	=	7.5	7.5	11	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	255	2	1	4	1.0	O=c1cc2c(nn1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	45484673	198958	None	0	Human	Functional	pEC50	=	7.5	7.5	8	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL585012	198958	None	0	Human	Functional	pEC50	=	7.5	7.5	8	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	44225654	187190	None	0	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	420	4	1	4	3.3	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2ccccc2Cl)CC1	10.1016/j.bmcl.2009.02.071
	CHEMBL492301	187190	None	0	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	420	4	1	4	3.3	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2ccccc2Cl)CC1	10.1016/j.bmcl.2009.02.071
	44573224	187231	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	406	4	1	4	2.9	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CC[C@H](Oc2ccccc2Cl)C1	10.1016/j.bmcl.2009.02.071
	CHEMBL492557	187231	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	406	4	1	4	2.9	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CC[C@H](Oc2ccccc2Cl)C1	10.1016/j.bmcl.2009.02.071
	44573159	193313	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	392	4	1	4	2.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CC(Oc2ccccc2Cl)C1	10.1016/j.bmcl.2009.02.071
	CHEMBL524171	193313	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	392	4	1	4	2.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CC(Oc2ccccc2Cl)C1	10.1016/j.bmcl.2009.02.071
	44316017	205452	None	0	Human	Functional	pEC50	=	7.5	7.5	-4	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80366	205452	None	0	Human	Functional	pEC50	=	7.5	7.5	-4	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	162659286	183695	None	0	Human	Functional	pEC50	=	7.5	7.5	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183695	None	0	Human	Functional	pEC50	=	7.5	7.5	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183695	None	0	Human	Functional	pEC50	=	7.5	7.5	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	122442270	138346	None	1	Human	Functional	pEC50	=	7.5	7.5	6	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138346	None	1	Human	Functional	pEC50	=	7.5	7.5	6	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138346	None	1	Human	Functional	pEC50	=	7.5	7.5	6	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	132820211	148566	None	0	Human	Functional	pEC50	=	7.5	7.5	3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	232	1	1	3	1.8	COc1cccc2c1N1CCCNC[C@H]1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3938893	148566	None	0	Human	Functional	pEC50	=	7.5	7.5	3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	232	1	1	3	1.8	COc1cccc2c1N1CCCNC[C@H]1CC2	10.1016/j.bmcl.2016.11.016
	54584721	61458	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770377	61458	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	155529999	171478	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccccc1Cc1cc2c(nn1)CCNCC2	10.1016/j.bmcl.2016.06.060
	CHEMBL4463588	171478	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccccc1Cc1cc2c(nn1)CCNCC2	10.1016/j.bmcl.2016.06.060
	155562772	175228	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccc(Cc2cc3c(nn2)CCNCC3)cc1	10.1016/j.bmcl.2016.06.060
	CHEMBL4571641	175228	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccc(Cc2cc3c(nn2)CCNCC3)cc1	10.1016/j.bmcl.2016.06.060
	137653689	158605	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	340	2	0	3	4.7	O=C(c1csc(-c2cccc(Cl)c2Cl)n1)N1CCCCC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4092132	158605	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	340	2	0	3	4.7	O=C(c1csc(-c2cccc(Cl)c2Cl)n1)N1CCCCC1	10.1021/acs.jmedchem.7b00385
	155534560	176421	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	2	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	243	2	1	1	2.6	NC[C@H]1C[C@]1(F)c1ccccc1Br	10.1016/j.ejmech.2019.111626
	CHEMBL4470610	176421	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	2	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	243	2	1	1	2.6	NC[C@H]1C[C@]1(F)c1ccccc1Br	10.1016/j.ejmech.2019.111626
	CHEMBL4596162	176421	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	2	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	243	2	1	1	2.6	NC[C@H]1C[C@]1(F)c1ccccc1Br	10.1016/j.ejmech.2019.111626
	137645667	157960	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2ccnc3ccccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	CHEMBL4084723	157960	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2ccnc3ccccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	134265590	164758	None	0	Human	Functional	pEC50	=	6.5	6.5	2	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1016/j.bmcl.2021.127872
	CHEMBL4217846	164758	None	0	Human	Functional	pEC50	=	6.5	6.5	2	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1016/j.bmcl.2021.127872
	24773894	62980	None	3	Human	Functional	pEC50	=	6.5	6.5	9	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL178566	62980	None	3	Human	Functional	pEC50	=	6.5	6.5	9	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	24773979	130169	None	21	Human	Functional	pEC50	=	6.5	6.5	4	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	CHEMBL367796	130169	None	21	Human	Functional	pEC50	=	6.5	6.5	4	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	10704473	79574	None	0	Rat	Functional	pEC50	=	6.5	6.5	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	226	2	1	2	2.8	C[C@H](N)Cn1ccc2c(Cl)c(F)ccc21	10.1021/jm970030l
	CHEMBL2114266	79574	None	0	Rat	Functional	pEC50	=	6.5	6.5	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	226	2	1	2	2.8	C[C@H](N)Cn1ccc2c(Cl)c(F)ccc21	10.1021/jm970030l
	1400243	94756	None	101	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	147	0	1	1	1.4	c1ccc2c(c1)CCNCC2	10.1021/jm0709034
	CHEMBL253155	94756	None	101	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	147	0	1	1	1.4	c1ccc2c(c1)CCNCC2	10.1021/jm0709034
	5745501	198182	None	1	Rat	Functional	pEC50	=	5.5	5.5	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	226	2	1	2	2.8	C[C@@H](N)Cn1ccc2cc(F)c(Cl)cc21	10.1021/jm970030l
	CHEMBL574985	198182	None	1	Rat	Functional	pEC50	=	5.5	5.5	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	226	2	1	2	2.8	C[C@@H](N)Cn1ccc2cc(F)c(Cl)cc21	10.1021/jm970030l
	45484896	198592	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	325	4	1	7	0.6	Cn1c(COc2cccc(C#N)c2)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	CHEMBL578564	198592	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	325	4	1	7	0.6	Cn1c(COc2cccc(C#N)c2)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	44412404	77768	None	6	Human	Functional	pEC50	=	6.5	6.5	-2	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209106	77768	None	6	Human	Functional	pEC50	=	6.5	6.5	-2	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	118733806	120655	None	0	Human	Functional	pEC50	=	7.5	7.5	19	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416055	120655	None	0	Human	Functional	pEC50	=	7.5	7.5	19	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546907	120655	None	0	Human	Functional	pEC50	=	7.5	7.5	19	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	58911644	91100	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	227	0	1	3	0.5	N#Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397895	91100	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	227	0	1	3	0.5	N#Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	137662193	159532	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	356	2	0	4	4.0	O=C(c1csc(-c2cccc(Cl)c2Cl)n1)N1CCCOCC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4102342	159532	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	356	2	0	4	4.0	O=C(c1csc(-c2cccc(Cl)c2Cl)n1)N1CCCOCC1	10.1021/acs.jmedchem.7b00385
	168280316	192863	None	0	Human	Functional	pEC50	=	5.5	5.5	41	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5187275	192863	None	0	Human	Functional	pEC50	=	5.5	5.5	41	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221883	192863	None	0	Human	Functional	pEC50	=	5.5	5.5	41	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	3	2	1	5.8	Clc1ccc2[nH]c3c(c2c1)CCNC3C(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.1c00694
	134265590	164758	None	0	Human	Functional	pEC50	=	6.5	6.5	2	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4217846	164758	None	0	Human	Functional	pEC50	=	6.5	6.5	2	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	58911666	91091	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397886	91091	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	162659286	183695	None	0	Human	Functional	pEC50	=	7.5	7.5	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183695	None	0	Human	Functional	pEC50	=	7.5	7.5	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183695	None	0	Human	Functional	pEC50	=	7.5	7.5	12	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	45484661	198881	None	0	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccccc1Cl)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL584210	198881	None	0	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccccc1Cl)CCNCC2	10.1016/j.bmcl.2009.07.063
	25070911	111671	None	0	Human	Functional	pEC50	=	7.5	7.5	7	2	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	324	3	1	5	1.6	c1ccc(Cc2nc3c(c(N4CCOCC4)n2)CCNCC3)cc1	10.1021/jm5003292
	CHEMBL3286564	111671	None	0	Human	Functional	pEC50	=	7.5	7.5	7	2	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	324	3	1	5	1.6	c1ccc(Cc2nc3c(c(N4CCOCC4)n2)CCNCC3)cc1	10.1021/jm5003292
	145966293	164454	None	0	Human	Functional	pEC50	=	7.5	7.5	14	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4213971	164454	None	0	Human	Functional	pEC50	=	7.5	7.5	14	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	11148641	91090	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
	CHEMBL2397885	91090	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
	54587668	61459	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770378	61459	None	0	Human	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	70696049	74461	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	271	4	1	2	3.6	COc1ccc(-c2ccccc2F)cc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022179	74461	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	271	4	1	2	3.6	COc1ccc(-c2ccccc2F)cc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027919	74461	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	271	4	1	2	3.6	COc1ccc(-c2ccccc2F)cc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	44572371	12527	None	0	Human	Functional	pEC50	=	6.5	6.5	5	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	CHEMBL1186608	12527	None	0	Human	Functional	pEC50	=	6.5	6.5	5	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	CHEMBL472678	12527	None	0	Human	Functional	pEC50	=	6.5	6.5	5	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	11222829	91111	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2cccc(C(F)(F)F)c2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397906	91111	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2cccc(C(F)(F)F)c2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	137654351	159015	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	350	3	1	5	2.6	Cc1nn(-c2cccc3ccccc23)nc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4096587	159015	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	350	3	1	5	2.6	Cc1nn(-c2cccc3ccccc23)nc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	45484734	197734	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	179	0	1	4	-0.5	Cn1nc2c(cc1=O)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL571512	197734	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	179	0	1	4	-0.5	Cn1nc2c(cc1=O)CCNCC2	10.1016/j.bmcl.2009.07.063
	168295067	193022	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5206340	193022	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222815	193022	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	168295067	193022	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5206340	193022	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222815	193022	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	346	2	2	2	4.7	COc1ccc2cc(C3NCCc4c3[nH]c3ccc(F)cc43)ccc2c1	10.1021/acsmedchemlett.1c00694
	11701315	199289	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
	CHEMBL590331	199289	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
	24773979	130169	None	21	Human	Functional	pEC50	=	6.5	6.5	4	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1016/j.bmcl.2004.12.080
	CHEMBL367796	130169	None	21	Human	Functional	pEC50	=	6.5	6.5	4	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1016/j.bmcl.2004.12.080
	44572694	187258	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	189	4	1	1	2.8	CC(C)NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL492696	187258	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	189	4	1	1	2.8	CC(C)NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	70689811	74474	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	267	4	1	2	3.7	COc1ccc(-c2ccccc2C)cc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2023356	74474	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	267	4	1	2	3.7	COc1ccc(-c2ccccc2C)cc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027981	74474	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	267	4	1	2	3.7	COc1ccc(-c2ccccc2C)cc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	16115515	137596	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	290	0	1	2	2.5	O=C1c2c(C(F)(F)F)ccc(Cl)c2[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL375575	137596	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	290	0	1	2	2.5	O=C1c2c(C(F)(F)F)ccc(Cl)c2[C@@H]2CNCCN12	10.1021/jm0612968
	44572180	12562	None	1	Human	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL1186737	12562	None	1	Human	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL475643	12562	None	1	Human	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	22292784	64594	None	15	Human	Functional	pEC50	=	7.5	7.5	5	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181672	64594	None	15	Human	Functional	pEC50	=	7.5	7.5	5	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	18545468	73981	None	65	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	237	1	1	1	2.8	Brc1ccc(C2=CCNCC2)cc1	10.1016/j.bmcl.2012.01.122
	CHEMBL2011569	73981	None	65	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	237	1	1	1	2.8	Brc1ccc(C2=CCNCC2)cc1	10.1016/j.bmcl.2012.01.122
	CHEMBL2021636	73981	None	65	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assayAgonist activity at 5HT2C receptor expressed in CHO cells by fluorescence based calcium mobilization assay	ChEMBL	237	1	1	1	2.8	Brc1ccc(C2=CCNCC2)cc1	10.1016/j.bmcl.2012.01.122
	154706030	176545	None	1	Human	Functional	pEC50	=	5.5	5.5	-35	2	Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assayAgonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4580817	176545	None	1	Human	Functional	pEC50	=	5.5	5.5	-35	2	Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assayAgonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4597188	176545	None	1	Human	Functional	pEC50	=	5.5	5.5	-35	2	Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assayAgonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	168294162	193011	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5208129	193011	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222770	193011	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168294162	193011	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5208129	193011	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222770	193011	None	0	Human	Functional	pEC50	=	5.5	5.5	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	24826786	91086	None	0	Human	Functional	pEC50	=	7.4	7.4	19	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397881	91086	None	0	Human	Functional	pEC50	=	7.4	7.4	19	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	122442266	138343	None	0	Human	Functional	pEC50	=	7.4	7.4	51	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138343	None	0	Human	Functional	pEC50	=	7.4	7.4	51	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138343	None	0	Human	Functional	pEC50	=	7.4	7.4	51	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442266	138343	None	0	Human	Functional	pEC50	=	7.4	7.4	51	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138343	None	0	Human	Functional	pEC50	=	7.4	7.4	51	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138343	None	0	Human	Functional	pEC50	=	7.4	7.4	51	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	45485727	197780	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.8	C[C@@H](Cn1nc(N2CCNCC2)ccc1=O)Oc1ccccc1Cl	10.1016/j.bmcl.2009.07.136
	CHEMBL571826	197780	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.8	C[C@@H](Cn1nc(N2CCNCC2)ccc1=O)Oc1ccccc1Cl	10.1016/j.bmcl.2009.07.136
	45484927	197304	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	352	4	1	6	1.6	Cn1c(COc2cc(F)ccc2Cl)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	CHEMBL568741	197304	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	352	4	1	6	1.6	Cn1c(COc2cc(F)ccc2Cl)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	53320653	56800	None	0	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	245	2	1	5	0.9	CCN(C)c1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	CHEMBL1643673	56800	None	0	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	245	2	1	5	0.9	CCN(C)c1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	11187156	136354	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	312	3	1	2	3.1	CCCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL373483	136354	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	312	3	1	2	3.1	CCCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	118733792	120672	None	0	Human	Functional	pEC50	=	6.4	6.4	12	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416048	120672	None	0	Human	Functional	pEC50	=	6.4	6.4	12	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546974	120672	None	0	Human	Functional	pEC50	=	6.4	6.4	12	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	44573228	187192	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	480	6	1	6	3.3	COc1cc(S(=O)(=O)N2CCC(Oc3ccccc3Cl)CC2)c(OC)c2c1CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492303	187192	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	480	6	1	6	3.3	COc1cc(S(=O)(=O)N2CCC(Oc3ccccc3Cl)CC2)c(OC)c2c1CCNCC2	10.1016/j.bmcl.2009.02.071
	137658246	159624	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	348	3	1	3	3.8	Cc1cn(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4103426	159624	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	348	3	1	3	3.8	Cc1cn(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	11737032	85016	None	0	Human	Functional	pEC50	=	7.4	7.4	13	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL223896	85016	None	0	Human	Functional	pEC50	=	7.4	7.4	13	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	53321865	56848	None	0	Human	Functional	pEC50	=	7.4	7.4	19	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643855	56848	None	0	Human	Functional	pEC50	=	7.4	7.4	19	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	168272608	192793	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192793	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192793	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	46884100	8017	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor	ChEMBL	314	5	2	3	3.0	O=C(NCc1ccc(Oc2cccc(F)c2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1090757	8017	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor	ChEMBL	314	5	2	3	3.0	O=C(NCc1ccc(Oc2cccc(F)c2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	137635711	156065	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	387	5	0	4	5.0	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N(C)CCc1cccnc1	10.1021/acs.jmedchem.7b00385
	CHEMBL4062681	156065	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	387	5	0	4	5.0	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N(C)CCc1cccnc1	10.1021/acs.jmedchem.7b00385
	168268703	192776	None	0	Human	Functional	pEC50	=	7.4	7.4	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170024	192776	None	0	Human	Functional	pEC50	=	7.4	7.4	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221265	192776	None	0	Human	Functional	pEC50	=	7.4	7.4	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	54585652	61453	None	33	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	211	1	1	3	1.8	c1ccc(-c2ncc3c(n2)CNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770368	61453	None	33	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	211	1	1	3	1.8	c1ccc(-c2ncc3c(n2)CNCC3)cc1	10.1016/j.bmcl.2010.11.120
	168272608	192793	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192793	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192793	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	70689809	74473	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	4	1	2	3.4	COc1ccc(-c2ccccc2)cc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2023355	74473	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	4	1	2	3.4	COc1ccc(-c2ccccc2)cc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027980	74473	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	4	1	2	3.4	COc1ccc(-c2ccccc2)cc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	137632042	156318	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	350	3	1	4	3.6	Cc1oc(-c2cccc3ccccc23)nc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4065606	156318	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	350	3	1	4	3.6	Cc1oc(-c2cccc3ccccc23)nc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	137639705	156751	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	302	3	0	4	4.1	CCn1nc(-c2cccc3ccccc23)cc1-c1cncn1C	10.1021/acs.jmedchem.7b00385
	CHEMBL4070587	156751	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	302	3	0	4	4.1	CCn1nc(-c2cccc3ccccc23)cc1-c1cncn1C	10.1021/acs.jmedchem.7b00385
	122442281	138352	None	0	Human	Functional	pEC50	=	6.4	6.4	5	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(Cl)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770058	138352	None	0	Human	Functional	pEC50	=	6.4	6.4	5	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(Cl)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771388	138352	None	0	Human	Functional	pEC50	=	6.4	6.4	5	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(Cl)c1F	10.1021/acs.jmedchem.5b01153
	122442281	138352	None	0	Human	Functional	pEC50	=	6.4	6.4	5	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(Cl)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770058	138352	None	0	Human	Functional	pEC50	=	6.4	6.4	5	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(Cl)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771388	138352	None	0	Human	Functional	pEC50	=	6.4	6.4	5	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(Cl)c1F	10.1021/acs.jmedchem.5b01153
	44431705	145126	None	0	Rat	Functional	pEC50	=	7.4	7.4	-6	2	Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	313	2	2	4	1.7	C[C@@H](N)[C@H](O)c1c2c(c(Br)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL391196	145126	None	0	Rat	Functional	pEC50	=	7.4	7.4	-6	2	Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	313	2	2	4	1.7	C[C@@H](N)[C@H](O)c1c2c(c(Br)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	168268703	192776	None	0	Human	Functional	pEC50	=	7.4	7.4	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170024	192776	None	0	Human	Functional	pEC50	=	7.4	7.4	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221265	192776	None	0	Human	Functional	pEC50	=	7.4	7.4	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	338	1	2	2	5.3	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cc2ccccc2s1	10.1021/acsmedchemlett.1c00694
	25070909	111669	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	268	3	2	4	1.8	CNc1nc(Cc2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	CHEMBL3286561	111669	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	268	3	2	4	1.8	CNc1nc(Cc2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	24773814	94859	None	1	Human	Functional	pEC50	=	7.4	7.4	6	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253809	94859	None	1	Human	Functional	pEC50	=	7.4	7.4	6	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	132820212	146792	None	0	Human	Functional	pEC50	=	7.4	7.4	3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	266	1	1	3	2.5	COc1cc2c(cc1Cl)N1CCCNC[C@H]1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3924644	146792	None	0	Human	Functional	pEC50	=	7.4	7.4	3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	266	1	1	3	2.5	COc1cc2c(cc1Cl)N1CCCNC[C@H]1CC2	10.1016/j.bmcl.2016.11.016
	10329912	62551	None	8	Human	Functional	pEC50	=	6.4	6.4	3	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	179	0	1	1	2.1	CC1CNCCc2ccc(F)cc21	10.1021/jm0709034
	CHEMBL178252	62551	None	8	Human	Functional	pEC50	=	6.4	6.4	3	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	179	0	1	1	2.1	CC1CNCCc2ccc(F)cc21	10.1021/jm0709034
	18986247	106197	None	0	Rat	Functional	pEC50	=	6.4	6.4	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	226	2	1	2	2.8	CC(N)Cn1ccc2cc(Cl)c(F)cc21	10.1021/jm970030l
	CHEMBL313856	106197	None	0	Rat	Functional	pEC50	=	6.4	6.4	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	226	2	1	2	2.8	CC(N)Cn1ccc2cc(Cl)c(F)cc21	10.1021/jm970030l
	10586264	161790	None	0	Rat	Functional	pEC50	=	6.4	6.4	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	242	3	1	3	2.4	COc1ccc2c(c1)-c1c(ccn1CC(C)N)C2	10.1021/jm970030l
	CHEMBL414163	161790	None	0	Rat	Functional	pEC50	=	6.4	6.4	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	242	3	1	3	2.4	COc1ccc2c(c1)-c1c(ccn1CC(C)N)C2	10.1021/jm970030l
	168280026	192858	None	0	Human	Functional	pEC50	=	5.4	5.4	-10	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5188655	192858	None	0	Human	Functional	pEC50	=	5.4	5.4	-10	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221857	192858	None	0	Human	Functional	pEC50	=	5.4	5.4	-10	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	137644936	161221	None	0	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	235	5	1	2	2.7	COc1ccc(F)cc1C1CC1CNC1CC1	10.1021/acs.jmedchem.7b00584
	CHEMBL4090984	161221	None	0	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	235	5	1	2	2.7	COc1ccc(F)cc1C1CC1CNC1CC1	10.1021/acs.jmedchem.7b00584
	CHEMBL4117952	161221	None	0	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	235	5	1	2	2.7	COc1ccc(F)cc1C1CC1CNC1CC1	10.1021/acs.jmedchem.7b00584
	9838040	85302	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assay	ChEMBL	258	4	1	3	2.9	CCOc1ccc2c(c1)c(C[C@H](C)N)c1n2CCC1	10.1007/s00044-011-9615-3
	CHEMBL2260565	85302	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assayAgonist activity at Homo sapiens (human) 5-HT2C receptor assessed as 5-HT-induced calcium mobilization by cell based assay	ChEMBL	258	4	1	3	2.9	CCOc1ccc2c(c1)c(C[C@H](C)N)c1n2CCC1	10.1007/s00044-011-9615-3
	24826869	91102	None	0	Human	Functional	pEC50	=	8.4	8.4	7	3	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397897	91102	None	0	Human	Functional	pEC50	=	8.4	8.4	7	3	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	9991444	62632	None	1	Human	Functional	pEC50	=	8.4	8.4	4	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178366	62632	None	1	Human	Functional	pEC50	=	8.4	8.4	4	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	10015414	63485	None	0	Human	Functional	pEC50	=	8.4	8.4	10	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179915	63485	None	0	Human	Functional	pEC50	=	8.4	8.4	10	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	92042919	120667	None	0	Human	Functional	pEC50	=	8.4	8.4	89	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416063	120667	None	0	Human	Functional	pEC50	=	8.4	8.4	89	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546958	120667	None	0	Human	Functional	pEC50	=	8.4	8.4	89	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	221	5	1	2	2.5	C=CCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	11493484	89070	None	0	Human	Functional	pEC50	=	8.4	8.4	23	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337106	89070	None	0	Human	Functional	pEC50	=	8.4	8.4	23	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365079	89070	None	0	Human	Functional	pEC50	=	8.4	8.4	23	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	168272754	192794	None	0	Human	Functional	pEC50	=	8.4	8.4	6	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5179588	192794	None	0	Human	Functional	pEC50	=	8.4	8.4	6	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221399	192794	None	0	Human	Functional	pEC50	=	8.4	8.4	6	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168272754	192794	None	0	Human	Functional	pEC50	=	8.4	8.4	6	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5179588	192794	None	0	Human	Functional	pEC50	=	8.4	8.4	6	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221399	192794	None	0	Human	Functional	pEC50	=	8.4	8.4	6	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	282	1	3	2	3.2	Oc1ccccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	135520431	72609	None	9	Rat	Functional	pEC50	=	8.4	8.4	1	2	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL199385	72609	None	9	Rat	Functional	pEC50	=	8.4	8.4	1	2	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	44431689	87249	None	0	Rat	Functional	pEC50	=	8.4	8.4	13	2	Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	383	7	1	6	2.6	C[C@@H](N)Cc1c2c(c(COCC(=O)Oc3ccccc3)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL232995	87249	None	0	Rat	Functional	pEC50	=	8.4	8.4	13	2	Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	383	7	1	6	2.6	C[C@@H](N)Cc1c2c(c(COCC(=O)Oc3ccccc3)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	25070582	61454	None	28	Human	Functional	pEC50	=	8.4	8.4	-2	9	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770373	61454	None	28	Human	Functional	pEC50	=	8.4	8.4	-2	9	Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	25070582	61454	None	28	Human	Functional	pEC50	=	8.4	8.4	-2	9	Agonist activity at human 5HT2C receptor highly expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor highly expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770373	61454	None	28	Human	Functional	pEC50	=	8.4	8.4	-2	9	Agonist activity at human 5HT2C receptor highly expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor highly expressed in Swiss mouse 3T3 cells increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	239	2	1	3	1.8	c1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	9859257	205123	None	0	Human	Functional	pEC50	=	8.4	8.4	-1	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL77880	205123	None	0	Human	Functional	pEC50	=	8.4	8.4	-1	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	166	3359	None	18	Human	Functional	pEC50	=	8.3	8.3	-2	4	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	3045227	3359	None	18	Human	Functional	pEC50	=	8.3	8.3	-2	4	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	CHEMBL76781	3359	None	18	Human	Functional	pEC50	=	8.3	8.3	-2	4	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	11446529	78328	None	3	Human	Functional	pEC50	=	8.3	8.3	2	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	165	2	1	1	1.8	NC[C@H]1C[C@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	CHEMBL2094028	78328	None	3	Human	Functional	pEC50	=	8.3	8.3	2	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	165	2	1	1	1.8	NC[C@H]1C[C@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	CHEMBL2109749	78328	None	3	Human	Functional	pEC50	=	8.3	8.3	2	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	165	2	1	1	1.8	NC[C@H]1C[C@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	166	3359	None	18	Human	Functional	pEC50	=	8.3	8.3	-2	4	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	3045227	3359	None	18	Human	Functional	pEC50	=	8.3	8.3	-2	4	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	CHEMBL76781	3359	None	18	Human	Functional	pEC50	=	8.3	8.3	-2	4	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm301656h
	11446529	78328	None	3	Human	Functional	pEC50	=	8.3	8.3	2	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	165	2	1	1	1.8	NC[C@H]1C[C@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	CHEMBL2094028	78328	None	3	Human	Functional	pEC50	=	8.3	8.3	2	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	165	2	1	1	1.8	NC[C@H]1C[C@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	CHEMBL2109749	78328	None	3	Human	Functional	pEC50	=	8.3	8.3	2	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	165	2	1	1	1.8	NC[C@H]1C[C@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	11658860	2344	None	51	Human	Functional	pEC50	=	8.3	8.3	1	11	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.ejmech.2019.111626
	2941	2344	None	51	Human	Functional	pEC50	=	8.3	8.3	1	11	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.ejmech.2019.111626
	4374	2344	None	51	Human	Functional	pEC50	=	8.3	8.3	1	11	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.ejmech.2019.111626
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.3	8.3	1	11	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.ejmech.2019.111626
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.3	8.3	1	11	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.ejmech.2019.111626
	11658860	2344	None	51	Human	Functional	pEC50	=	8.3	8.3	1	11	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.ejmech.2019.111626
	2941	2344	None	51	Human	Functional	pEC50	=	8.3	8.3	1	11	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.ejmech.2019.111626
	4374	2344	None	51	Human	Functional	pEC50	=	8.3	8.3	1	11	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.ejmech.2019.111626
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.3	8.3	1	11	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.ejmech.2019.111626
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.3	8.3	1	11	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.ejmech.2019.111626
	44572802	12444	None	2	Human	Functional	pEC50	=	8.3	8.3	13	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186019	12444	None	2	Human	Functional	pEC50	=	8.3	8.3	13	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL445747	12444	None	2	Human	Functional	pEC50	=	8.3	8.3	13	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	135509961	136132	None	2	Rat	Functional	pEC50	=	8.3	8.3	1	2	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	CHEMBL373245	136132	None	2	Rat	Functional	pEC50	=	8.3	8.3	1	2	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	46884138	8443	None	0	Human	Functional	pEC50	=	8.3	8.3	100	3	Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1093699	8443	None	0	Human	Functional	pEC50	=	8.3	8.3	100	3	Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	44316027	205522	None	0	Human	Functional	pEC50	=	7.4	7.4	1	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL80862	205522	None	0	Human	Functional	pEC50	=	7.4	7.4	1	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	146025685	183659	None	0	Human	Functional	pEC50	=	7.4	7.4	19	2	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752976	183659	None	0	Human	Functional	pEC50	=	7.4	7.4	19	2	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802794	183659	None	0	Human	Functional	pEC50	=	7.4	7.4	19	2	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	162669436	183745	None	0	Human	Functional	pEC50	=	7.4	7.4	19	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4789310	183745	None	0	Human	Functional	pEC50	=	7.4	7.4	19	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803705	183745	None	0	Human	Functional	pEC50	=	7.4	7.4	19	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	2760428	199861	None	47	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	220	1	1	5	1.1	c1nc(N2CCNCC2)c2sccc2n1	10.1016/j.bmcl.2009.10.112
	CHEMBL594477	199861	None	47	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	220	1	1	5	1.1	c1nc(N2CCNCC2)c2sccc2n1	10.1016/j.bmcl.2009.10.112
	168280026	192858	None	0	Human	Functional	pEC50	=	5.4	5.4	-10	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5188655	192858	None	0	Human	Functional	pEC50	=	5.4	5.4	-10	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	CHEMBL5221857	192858	None	0	Human	Functional	pEC50	=	5.4	5.4	-10	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	2	3.1	Fc1ccc2[nH]c3c(c2c1)CCNC3c1cccnc1F	10.1021/acsmedchemlett.1c00694
	4543677	192790	None	1	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192790	None	1	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192790	None	1	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	45485786	197824	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	362	6	1	6	2.2	CC[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2Cl)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL572231	197824	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	362	6	1	6	2.2	CC[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2Cl)n1	10.1016/j.bmcl.2009.07.136
	137655188	161225	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	328	7	2	3	2.8	COc1ccc(F)cc1C1CC1CNCc1ccccc1C(N)=O	10.1021/acs.jmedchem.7b00584
	CHEMBL4094054	161225	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	328	7	2	3	2.8	COc1ccc(F)cc1C1CC1CNCc1ccccc1C(N)=O	10.1021/acs.jmedchem.7b00584
	CHEMBL4117988	161225	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	328	7	2	3	2.8	COc1ccc(F)cc1C1CC1CNCc1ccccc1C(N)=O	10.1021/acs.jmedchem.7b00584
	4543677	192790	None	1	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192790	None	1	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192790	None	1	Human	Functional	pEC50	=	6.4	6.4	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	155535970	176655	None	0	Human	Functional	pEC50	=	5.4	5.4	-4	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	165	2	1	1	1.8	NC[C@@H]1C[C@@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	CHEMBL4472830	176655	None	0	Human	Functional	pEC50	=	5.4	5.4	-4	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	165	2	1	1	1.8	NC[C@@H]1C[C@@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	CHEMBL4598081	176655	None	0	Human	Functional	pEC50	=	5.4	5.4	-4	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	165	2	1	1	1.8	NC[C@@H]1C[C@@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	137655188	161225	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	328	7	2	3	2.8	COc1ccc(F)cc1C1CC1CNCc1ccccc1C(N)=O	10.1021/acs.jmedchem.7b00584
	CHEMBL4094054	161225	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	328	7	2	3	2.8	COc1ccc(F)cc1C1CC1CNCc1ccccc1C(N)=O	10.1021/acs.jmedchem.7b00584
	CHEMBL4117988	161225	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	328	7	2	3	2.8	COc1ccc(F)cc1C1CC1CNCc1ccccc1C(N)=O	10.1021/acs.jmedchem.7b00584
	11595191	89060	None	0	Human	Functional	pEC50	=	7.4	7.4	6	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337488	89060	None	0	Human	Functional	pEC50	=	7.4	7.4	6	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364960	89060	None	0	Human	Functional	pEC50	=	7.4	7.4	6	3	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	146025685	183659	None	0	Human	Functional	pEC50	=	7.4	7.4	19	2	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752976	183659	None	0	Human	Functional	pEC50	=	7.4	7.4	19	2	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802794	183659	None	0	Human	Functional	pEC50	=	7.4	7.4	19	2	Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	251	5	1	3	2.0	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	162669436	183745	None	0	Human	Functional	pEC50	=	7.4	7.4	19	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4789310	183745	None	0	Human	Functional	pEC50	=	7.4	7.4	19	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803705	183745	None	0	Human	Functional	pEC50	=	7.4	7.4	19	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	42601404	187230	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	372	4	1	4	2.2	CN(CC1COc2ccccc21)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492556	187230	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	372	4	1	4	2.2	CN(CC1COc2ccccc21)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	137639630	156920	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	348	3	1	3	3.7	Cn1cc(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4072337	156920	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	348	3	1	3	3.7	Cn1cc(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	44383324	120456	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line	ChEMBL	246	2	1	2	3.1	Cc1c(CCN)c2cc(F)cc3c2n1C(C)CC3	10.1016/s0960-894x(00)00141-4
	CHEMBL353998	120456	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line	ChEMBL	246	2	1	2	3.1	Cc1c(CCN)c2cc(F)cc3c2n1C(C)CC3	10.1016/s0960-894x(00)00141-4
	168291564	192983	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	192983	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	192983	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	122442324	138350	None	0	Human	Functional	pEC50	=	7.4	7.4	12	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138350	None	0	Human	Functional	pEC50	=	7.4	7.4	12	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138350	None	0	Human	Functional	pEC50	=	7.4	7.4	12	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	10329912	62551	None	8	Human	Functional	pEC50	=	6.4	6.4	3	2	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	179	0	1	1	2.1	CC1CNCCc2ccc(F)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178252	62551	None	8	Human	Functional	pEC50	=	6.4	6.4	3	2	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	179	0	1	1	2.1	CC1CNCCc2ccc(F)cc21	10.1016/j.bmcl.2004.12.080
	155535970	176655	None	0	Human	Functional	pEC50	=	5.4	5.4	-4	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	165	2	1	1	1.8	NC[C@@H]1C[C@@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	CHEMBL4472830	176655	None	0	Human	Functional	pEC50	=	5.4	5.4	-4	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	165	2	1	1	1.8	NC[C@@H]1C[C@@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	CHEMBL4598081	176655	None	0	Human	Functional	pEC50	=	5.4	5.4	-4	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	165	2	1	1	1.8	NC[C@@H]1C[C@@]1(F)c1ccccc1	10.1016/j.ejmech.2019.111626
	14515725	87310	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	CHEMBL2331807	87310	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	168284944	192913	None	0	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	3	2.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192557	192913	None	0	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	3	2.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222162	192913	None	0	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	3	2.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	46230048	199290	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
	CHEMBL590332	199290	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
	11437171	83490	None	0	Human	Functional	pEC50	=	7.4	7.4	2	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL220207	83490	None	0	Human	Functional	pEC50	=	7.4	7.4	2	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	44573014	12521	None	1	Human	Functional	pEC50	=	7.4	7.4	10	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL1186595	12521	None	1	Human	Functional	pEC50	=	7.4	7.4	10	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL471802	12521	None	1	Human	Functional	pEC50	=	7.4	7.4	10	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	168291564	192983	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	192983	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	192983	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	122442324	138350	None	0	Human	Functional	pEC50	=	7.4	7.4	12	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138350	None	0	Human	Functional	pEC50	=	7.4	7.4	12	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138350	None	0	Human	Functional	pEC50	=	7.4	7.4	12	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	14515725	87310	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	CHEMBL2331807	87310	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	244	2	1	4	1.2	O=c1c2c(on1Cc1ccccc1)CCNCC2	10.1021/jm301656h
	168284944	192913	None	0	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	3	2.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192557	192913	None	0	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	3	2.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222162	192913	None	0	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	284	1	2	3	2.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cncnc1	10.1021/acsmedchemlett.1c00694
	24773900	123432	None	8	Human	Functional	pEC50	=	6.4	6.4	1	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL361742	123432	None	8	Human	Functional	pEC50	=	6.4	6.4	1	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	44412405	77781	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209155	77781	None	0	Human	Functional	pEC50	=	6.4	6.4	-2	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	11427139	84687	None	0	Human	Functional	pEC50	=	7.4	7.4	38	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL222566	84687	None	0	Human	Functional	pEC50	=	7.4	7.4	38	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	11492300	89111	None	1	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	188	0	2	2	0.5	O=C1N[C@H]2CNC[C@@H]2c2ccccc21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337495	89111	None	1	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	188	0	2	2	0.5	O=C1N[C@H]2CNC[C@@H]2c2ccccc21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365471	89111	None	1	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	188	0	2	2	0.5	O=C1N[C@H]2CNC[C@@H]2c2ccccc21	10.1016/j.bmcl.2012.10.091
	46230049	201545	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL605402	201545	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	137637165	156214	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	351	2	0	4	3.7	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCN(C)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4064423	156214	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	351	2	0	4	3.7	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCN(C)CC1	10.1021/acs.jmedchem.7b00385
	5	139	None	72	Human	Functional	pEC50	=	7.4	7.4	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5202	139	None	72	Human	Functional	pEC50	=	7.4	7.4	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	7.4	7.4	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	DB08839	139	None	72	Human	Functional	pEC50	=	7.4	7.4	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	168268771	192791	None	0	Human	Functional	pEC50	=	7.4	7.4	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5174331	192791	None	0	Human	Functional	pEC50	=	7.4	7.4	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221385	192791	None	0	Human	Functional	pEC50	=	7.4	7.4	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	137655657	158782	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	316	7	1	4	3.1	COc1ccc(F)cc1C1CC1CNCc1cccnc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4094164	158782	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	316	7	1	4	3.1	COc1ccc(F)cc1C1CC1CNCc1cccnc1OC	10.1021/acs.jmedchem.7b00584
	122442307	138355	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3770950	138355	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771391	138355	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	137655657	158782	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	316	7	1	4	3.1	COc1ccc(F)cc1C1CC1CNCc1cccnc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4094164	158782	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	316	7	1	4	3.1	COc1ccc(F)cc1C1CC1CNCc1cccnc1OC	10.1021/acs.jmedchem.7b00584
	122442307	138355	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3770950	138355	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771391	138355	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	277	5	1	2	3.4	NCC1CC1c1cc(Cl)c(Cl)cc1OCCF	10.1021/acs.jmedchem.5b01153
	46884137	8442	None	0	Human	Functional	pEC50	=	7.4	7.4	3	2	Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor	ChEMBL	352	5	2	3	3.3	C[C@H]1CC[C@@H](Oc2c(F)cc(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	CHEMBL1093698	8442	None	0	Human	Functional	pEC50	=	7.4	7.4	3	2	Agonist activity at 5HT2C receptorAgonist activity at 5HT2C receptor	ChEMBL	352	5	2	3	3.3	C[C@H]1CC[C@@H](Oc2c(F)cc(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	5	139	None	72	Human	Functional	pEC50	=	7.4	7.4	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	5202	139	None	72	Human	Functional	pEC50	=	7.4	7.4	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	CHEMBL39	139	None	72	Human	Functional	pEC50	=	7.4	7.4	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	DB08839	139	None	72	Human	Functional	pEC50	=	7.4	7.4	-3	26	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins at RT by TR-FRET assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm301656h
	168268771	192791	None	0	Human	Functional	pEC50	=	7.4	7.4	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5174331	192791	None	0	Human	Functional	pEC50	=	7.4	7.4	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221385	192791	None	0	Human	Functional	pEC50	=	7.4	7.4	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	322	1	2	2	4.8	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Cl)s1	10.1021/acsmedchemlett.1c00694
	168	3982	None	15	Human	Functional	pEC50	=	7.4	7.4	-3	5	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	6604042	3982	None	15	Human	Functional	pEC50	=	7.4	7.4	-3	5	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	CHEMBL309760	3982	None	15	Human	Functional	pEC50	=	7.4	7.4	-3	5	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	18735313	204934	None	1	Human	Functional	pEC50	=	7.4	7.4	-6	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76307	204934	None	1	Human	Functional	pEC50	=	7.4	7.4	-6	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	21072529	176422	None	5	Human	Functional	pEC50	=	5.4	5.4	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	183	2	1	1	2.0	NCC1C(c2ccccc2)C1(F)F	10.1016/j.ejmech.2019.111626
	CHEMBL4457840	176422	None	5	Human	Functional	pEC50	=	5.4	5.4	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	183	2	1	1	2.0	NCC1C(c2ccccc2)C1(F)F	10.1016/j.ejmech.2019.111626
	CHEMBL4596163	176422	None	5	Human	Functional	pEC50	=	5.4	5.4	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	183	2	1	1	2.0	NCC1C(c2ccccc2)C1(F)F	10.1016/j.ejmech.2019.111626
	162668416	183740	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	285	6	1	3	3.8	CCc1cc2c([C@@H]3C[C@H]3CN)c(OCC3CC3)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4787862	183740	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	285	6	1	3	3.8	CCc1cc2c([C@@H]3C[C@H]3CN)c(OCC3CC3)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803644	183740	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	285	6	1	3	3.8	CCc1cc2c([C@@H]3C[C@H]3CN)c(OCC3CC3)ccc2o1	10.1021/acs.jmedchem.6b01194
	168268736	192789	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192789	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192789	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	162668416	183740	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	285	6	1	3	3.8	CCc1cc2c([C@@H]3C[C@H]3CN)c(OCC3CC3)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4787862	183740	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	285	6	1	3	3.8	CCc1cc2c([C@@H]3C[C@H]3CN)c(OCC3CC3)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803644	183740	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	285	6	1	3	3.8	CCc1cc2c([C@@H]3C[C@H]3CN)c(OCC3CC3)ccc2o1	10.1021/acs.jmedchem.6b01194
	168268736	192789	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192789	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192789	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	4995534	192852	None	1	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	366	1	2	2	4.9	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5188386	192852	None	1	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	366	1	2	2	4.9	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221773	192852	None	1	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	366	1	2	2	4.9	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)s1	10.1021/acsmedchemlett.1c00694
	21072529	176422	None	5	Human	Functional	pEC50	=	5.4	5.4	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	183	2	1	1	2.0	NCC1C(c2ccccc2)C1(F)F	10.1016/j.ejmech.2019.111626
	CHEMBL4457840	176422	None	5	Human	Functional	pEC50	=	5.4	5.4	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	183	2	1	1	2.0	NCC1C(c2ccccc2)C1(F)F	10.1016/j.ejmech.2019.111626
	CHEMBL4596163	176422	None	5	Human	Functional	pEC50	=	5.4	5.4	-1	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	183	2	1	1	2.0	NCC1C(c2ccccc2)C1(F)F	10.1016/j.ejmech.2019.111626
	4995534	192852	None	1	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	366	1	2	2	4.9	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5188386	192852	None	1	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	366	1	2	2	4.9	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)s1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221773	192852	None	1	Human	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	366	1	2	2	4.9	Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccc(Br)s1	10.1021/acsmedchemlett.1c00694
	11615459	199248	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590078	199248	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	12986496	202708	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	257	0	2	3	2.2	Clc1cc2c(cc1Cl)N1CCNC[C@H]1CN2	10.1016/s0960-894x(00)00400-5
	CHEMBL61695	202708	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	257	0	2	3	2.2	Clc1cc2c(cc1Cl)N1CCNC[C@H]1CN2	10.1016/s0960-894x(00)00400-5
	137651715	157391	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	304	3	0	6	2.9	CCn1nc(-c2cccc3ccccc23)cc1-c1nnnn1C	10.1021/acs.jmedchem.7b00385
	CHEMBL4078339	157391	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	304	3	0	6	2.9	CCn1nc(-c2cccc3ccccc23)cc1-c1nnnn1C	10.1021/acs.jmedchem.7b00385
	137658074	159565	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2cccc3ncccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	CHEMBL4102653	159565	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2cccc3ncccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	53324629	56799	None	0	Human	Functional	pEC50	=	5.3	5.3	-7	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643672	56799	None	0	Human	Functional	pEC50	=	5.3	5.3	-7	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	16115511	84837	None	0	Human	Functional	pEC50	=	7.3	7.3	6	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223466	84837	None	0	Human	Functional	pEC50	=	7.3	7.3	6	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	45484909	198513	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	332	4	1	6	1.2	Cc1ccc(F)cc1OCc1nc(N2CCNCC2)cc(=O)n1C	10.1016/j.bmcl.2009.07.133
	CHEMBL577832	198513	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	332	4	1	6	1.2	Cc1ccc(F)cc1OCc1nc(N2CCNCC2)cc(=O)n1C	10.1016/j.bmcl.2009.07.133
	44573154	187198	None	0	Human	Functional	pEC50	=	7.3	7.3	17	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	350	4	2	3	2.5	O=S(=O)(NCc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492349	187198	None	0	Human	Functional	pEC50	=	7.3	7.3	17	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	350	4	2	3	2.5	O=S(=O)(NCc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	168291896	192985	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	192985	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	192985	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	137635932	155986	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	308	2	0	4	2.9	O=C(c1csc(-c2ccccc2Cl)n1)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4061625	155986	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	308	2	0	4	2.9	O=C(c1csc(-c2ccccc2Cl)n1)N1CCOCC1	10.1021/acs.jmedchem.7b00385
	168277801	192844	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	3	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5176879	192844	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	3	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221724	192844	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	3	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	168277801	192844	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	3	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5176879	192844	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	3	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221724	192844	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	3	2	1	4.1	Fc1ccc2[nH]c3c(c2c1)CCNC3CCc1ccccc1	10.1021/acsmedchemlett.1c00694
	168291896	192985	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	192985	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	192985	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	44626357	197552	None	0	Human	Functional	pEC50	=	7.3	7.3	1	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	382	5	1	6	2.1	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2C(F)(F)F)n1	10.1016/j.bmcl.2009.07.133
	CHEMBL570274	197552	None	0	Human	Functional	pEC50	=	7.3	7.3	1	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	382	5	1	6	2.1	C[C@@H]1CNCCN1c1ccc(=O)n(CCOc2ccccc2C(F)(F)F)n1	10.1016/j.bmcl.2009.07.133
	44573156	187297	None	0	Human	Functional	pEC50	=	7.3	7.3	2	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	254	2	1	3	0.6	CN(C)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492949	187297	None	0	Human	Functional	pEC50	=	7.3	7.3	2	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	254	2	1	3	0.6	CN(C)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	45485781	197391	None	0	Human	Functional	pEC50	=	7.3	7.3	23	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	368	5	1	6	1.8	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1C(F)(F)F	10.1016/j.bmcl.2009.07.136
	CHEMBL569342	197391	None	0	Human	Functional	pEC50	=	7.3	7.3	23	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	368	5	1	6	1.8	O=c1ccc(N2CCNCC2)nn1CCOc1ccccc1C(F)(F)F	10.1016/j.bmcl.2009.07.136
	137646716	157778	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	365	3	1	3	4.7	Cc1sc(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4082829	157778	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	365	3	1	3	4.7	Cc1sc(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	137655705	158940	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	352	2	1	4	3.9	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCC(O)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4095818	158940	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	352	2	1	4	3.9	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCC(O)CC1	10.1021/acs.jmedchem.7b00385
	11312820	136334	None	1	Human	Functional	pEC50	=	6.3	6.3	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	CHEMBL373402	136334	None	1	Human	Functional	pEC50	=	6.3	6.3	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	168295538	193039	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5207179	193039	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222923	193039	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	58911668	91110	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397905	91110	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	45484686	197696	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	339	3	1	5	1.9	O=c1cc2c(nn1Cc1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL571288	197696	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	339	3	1	5	1.9	O=c1cc2c(nn1Cc1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	122442275	138361	None	0	Human	Functional	pEC50	=	7.3	7.3	9	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138361	None	0	Human	Functional	pEC50	=	7.3	7.3	9	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138361	None	0	Human	Functional	pEC50	=	7.3	7.3	9	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	16115388	137366	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL375302	137366	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	54584720	61455	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	3	1	3	2.0	c1ccc(CCc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770374	61455	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2C receptor expressed in Swiss mouse 3T3 cells with low expression increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	3	1	3	2.0	c1ccc(CCc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	168295538	193039	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5207179	193039	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222923	193039	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	278	2	3	2	3.3	Oc1ccc2[nH]c3c(c2c1)CCNC3Cc1ccccc1	10.1021/acsmedchemlett.1c00694
	45484879	196821	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	368	4	1	6	1.8	Cn1c(COc2cccc(C(F)(F)F)c2)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	CHEMBL565736	196821	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	368	4	1	6	1.8	Cn1c(COc2cccc(C(F)(F)F)c2)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	11483068	84812	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223440	84812	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	44572757	12649	None	1	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	CHEMBL1187186	12649	None	1	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	CHEMBL492917	12649	None	1	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	122442275	138361	None	0	Human	Functional	pEC50	=	7.3	7.3	9	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138361	None	0	Human	Functional	pEC50	=	7.3	7.3	9	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138361	None	0	Human	Functional	pEC50	=	7.3	7.3	9	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	12986495	100596	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	257	0	2	3	2.2	Clc1cc2c(cc1Cl)N1CCNC[C@@H]1CN2	10.1016/s0960-894x(00)00400-5
	CHEMBL291794	100596	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	257	0	2	3	2.2	Clc1cc2c(cc1Cl)N1CCNC[C@@H]1CN2	10.1016/s0960-894x(00)00400-5
	45484888	197817	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	334	4	1	6	1.4	Cn1c(COc2cccc(Cl)c2)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	CHEMBL572183	197817	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	334	4	1	6	1.4	Cn1c(COc2cccc(Cl)c2)nc(N2CCNCC2)cc1=O	10.1016/j.bmcl.2009.07.133
	45484727	197170	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	227	2	1	3	1.6	c1ccc(Cn2cc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	CHEMBL568005	197170	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	227	2	1	3	1.6	c1ccc(Cn2cc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	45484727	197170	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	227	2	1	3	1.6	c1ccc(Cn2cc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2016.06.060
	CHEMBL568005	197170	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	227	2	1	3	1.6	c1ccc(Cn2cc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2016.06.060
	16115513	136402	None	0	Human	Functional	pEC50	=	8.3	8.3	43	2	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL373531	136402	None	0	Human	Functional	pEC50	=	8.3	8.3	43	2	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	24826790	91094	None	0	Human	Functional	pEC50	=	8.3	8.3	12	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397889	91094	None	0	Human	Functional	pEC50	=	8.3	8.3	12	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	53324630	56803	None	0	Human	Functional	pEC50	=	8.3	8.3	18	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643676	56803	None	0	Human	Functional	pEC50	=	8.3	8.3	18	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	137647635	157630	None	0	Human	Functional	pEC50	=	8.3	8.3	9	3	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	316	3	1	6	3.2	CCn1nc(-c2cccc3cccnc23)cc1-c1ccc(N)nn1	10.1021/acs.jmedchem.7b00385
	CHEMBL4081247	157630	None	0	Human	Functional	pEC50	=	8.3	8.3	9	3	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	316	3	1	6	3.2	CCn1nc(-c2cccc3cccnc23)cc1-c1ccc(N)nn1	10.1021/acs.jmedchem.7b00385
	9881885	64109	None	0	Human	Functional	pEC50	=	8.3	8.3	15	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180815	64109	None	0	Human	Functional	pEC50	=	8.3	8.3	15	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	44389646	64883	None	0	Human	Functional	pEC50	=	8.3	8.3	6	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL182184	64883	None	0	Human	Functional	pEC50	=	8.3	8.3	6	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	134265669	180245	None	0	Human	Functional	pEC50	=	8.3	8.3	10	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	223	0	1	3	1.5	Clc1ccnc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	CHEMBL4750216	180245	None	0	Human	Functional	pEC50	=	8.3	8.3	10	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	223	0	1	3	1.5	Clc1ccnc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	134265737	182403	None	0	Human	Functional	pEC50	=	8.3	8.3	158	2	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	233	2	1	4	1.0	COCc1ccnc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	CHEMBL4785566	182403	None	0	Human	Functional	pEC50	=	8.3	8.3	158	2	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	233	2	1	4	1.0	COCc1ccnc2c1CC[C@@H]1CNCCN21	10.1016/j.bmcl.2021.127872
	44572749	12437	None	1	Human	Functional	pEC50	=	8.3	8.3	6	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL1185954	12437	None	1	Human	Functional	pEC50	=	8.3	8.3	6	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL443128	12437	None	1	Human	Functional	pEC50	=	8.3	8.3	6	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	44572657	12467	None	6	Human	Functional	pEC50	=	8.3	8.3	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL1186169	12467	None	6	Human	Functional	pEC50	=	8.3	8.3	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL452719	12467	None	6	Human	Functional	pEC50	=	8.3	8.3	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	146025686	183759	None	0	Human	Functional	pEC50	=	8.3	8.3	21	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183759	None	0	Human	Functional	pEC50	=	8.3	8.3	21	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183759	None	0	Human	Functional	pEC50	=	8.3	8.3	21	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	146025686	183759	None	0	Human	Functional	pEC50	=	8.3	8.3	21	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183759	None	0	Human	Functional	pEC50	=	8.3	8.3	21	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183759	None	0	Human	Functional	pEC50	=	8.3	8.3	21	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	44572810	12655	None	2	Human	Functional	pEC50	=	8.3	8.3	3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL1187196	12655	None	2	Human	Functional	pEC50	=	8.3	8.3	3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL493130	12655	None	2	Human	Functional	pEC50	=	8.3	8.3	3	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	53325935	56797	None	0	Human	Functional	pEC50	=	8.3	8.3	17	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643670	56797	None	0	Human	Functional	pEC50	=	8.3	8.3	17	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	135399866	72055	None	2	Rat	Functional	pEC50	=	8.3	8.3	1	2	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	CHEMBL197653	72055	None	2	Rat	Functional	pEC50	=	8.3	8.3	1	2	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	9794638	120789	None	0	Human	Functional	pEC50	=	8.2	8.2	46	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line	ChEMBL	232	2	1	2	2.8	CC1CCc2cc(F)cc3c(CCN)cn1c23	10.1016/s0960-894x(00)00141-4
	CHEMBL355474	120789	None	0	Human	Functional	pEC50	=	8.2	8.2	46	2	Functional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell lineFunctional agonist activity of compound was determined by fluorescence-based assay measuring intracellular calcium mobilization for 5-HT2c receptor cell line	ChEMBL	232	2	1	2	2.8	CC1CCc2cc(F)cc3c(CCN)cn1c23	10.1016/s0960-894x(00)00141-4
	134265622	164753	None	0	Human	Functional	pEC50	=	8.2	8.2	81	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4217787	164753	None	0	Human	Functional	pEC50	=	8.2	8.2	81	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	44573221	193080	None	0	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	280	2	1	3	1.2	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCC1	10.1016/j.bmcl.2009.02.071
	CHEMBL522514	193080	None	0	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	280	2	1	3	1.2	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCC1	10.1016/j.bmcl.2009.02.071
	168281505	192880	None	0	Human	Functional	pEC50	=	7.3	7.3	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5188678	192880	None	0	Human	Functional	pEC50	=	7.3	7.3	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221963	192880	None	0	Human	Functional	pEC50	=	7.3	7.3	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	24773650	154697	None	2	Human	Functional	pEC50	=	7.3	7.3	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	CHEMBL399750	154697	None	2	Human	Functional	pEC50	=	7.3	7.3	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	168281505	192880	None	0	Human	Functional	pEC50	=	7.3	7.3	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5188678	192880	None	0	Human	Functional	pEC50	=	7.3	7.3	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221963	192880	None	0	Human	Functional	pEC50	=	7.3	7.3	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	285	1	2	3	3.1	Cc1noc(C)c1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	498210	199986	None	2	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	248	2	1	5	0.8	COc1nc(N2CCNCC2)nc2c1CCCC2	10.1016/j.bmcl.2009.10.112
	CHEMBL595196	199986	None	2	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	248	2	1	5	0.8	COc1nc(N2CCNCC2)nc2c1CCCC2	10.1016/j.bmcl.2009.10.112
	137642149	158361	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	302	2	0	4	2.9	Cc1cccc(-c2nc(C(=O)N3CCOCC3)cs2)c1C	10.1021/acs.jmedchem.7b00385
	CHEMBL4089670	158361	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	302	2	0	4	2.9	Cc1cccc(-c2nc(C(=O)N3CCOCC3)cs2)c1C	10.1021/acs.jmedchem.7b00385
	137630488	161076	None	0	Human	Functional	pEC50	=	6.3	6.3	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	303	6	1	2	3.9	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1ccccc1F	10.1021/acs.jmedchem.7b00584
	CHEMBL4101789	161076	None	0	Human	Functional	pEC50	=	6.3	6.3	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	303	6	1	2	3.9	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1ccccc1F	10.1021/acs.jmedchem.7b00584
	CHEMBL4116752	161076	None	0	Human	Functional	pEC50	=	6.3	6.3	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	303	6	1	2	3.9	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1ccccc1F	10.1021/acs.jmedchem.7b00584
	19036377	207823	None	0	Rat	Functional	pEC50	=	6.3	6.3	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	226	2	1	2	2.7	Cc1ccc2c(c1)-c1c(ccn1CC(C)N)C2	10.1021/jm970030l
	CHEMBL96312	207823	None	0	Rat	Functional	pEC50	=	6.3	6.3	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	226	2	1	2	2.7	Cc1ccc2c(c1)-c1c(ccn1CC(C)N)C2	10.1021/jm970030l
	137630488	161076	None	0	Human	Functional	pEC50	=	6.3	6.3	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	303	6	1	2	3.9	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1ccccc1F	10.1021/acs.jmedchem.7b00584
	CHEMBL4101789	161076	None	0	Human	Functional	pEC50	=	6.3	6.3	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	303	6	1	2	3.9	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1ccccc1F	10.1021/acs.jmedchem.7b00584
	CHEMBL4116752	161076	None	0	Human	Functional	pEC50	=	6.3	6.3	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	303	6	1	2	3.9	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1ccccc1F	10.1021/acs.jmedchem.7b00584
	44412403	77798	None	0	Human	Functional	pEC50	=	6.3	6.3	-8	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209254	77798	None	0	Human	Functional	pEC50	=	6.3	6.3	-8	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	10624	70300	None	19	Human	Functional	pEC50	=	6.3	6.3	-6	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	10624.0	70300	None	19	Human	Functional	pEC50	=	6.3	6.3	-6	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	138543650	70300	None	19	Human	Functional	pEC50	=	6.3	6.3	-6	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL194378	70300	None	19	Human	Functional	pEC50	=	6.3	6.3	-6	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	DB11664	70300	None	19	Human	Functional	pEC50	=	6.3	6.3	-6	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	44573225	192622	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	386	4	1	4	2.6	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2ccccc2)CC1	10.1016/j.bmcl.2009.02.071
	CHEMBL521644	192622	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	386	4	1	4	2.6	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCC(Oc2ccccc2)CC1	10.1016/j.bmcl.2009.02.071
	122442293	138342	None	0	Human	Functional	pEC50	=	6.3	6.3	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138342	None	0	Human	Functional	pEC50	=	6.3	6.3	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138342	None	0	Human	Functional	pEC50	=	6.3	6.3	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	59312310	111668	None	1	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	269	3	1	4	1.8	COc1nc(Cc2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	CHEMBL3286560	111668	None	1	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	269	3	1	4	1.8	COc1nc(Cc2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	45485769	197369	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.7	Cc1cc(=O)n(CCOc2ccccc2Cl)nc1N1CCNCC1	10.1016/j.bmcl.2009.07.136
	CHEMBL569208	197369	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.7	Cc1cc(=O)n(CCOc2ccccc2Cl)nc1N1CCNCC1	10.1016/j.bmcl.2009.07.136
	122442293	138342	None	0	Human	Functional	pEC50	=	6.3	6.3	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138342	None	0	Human	Functional	pEC50	=	6.3	6.3	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138342	None	0	Human	Functional	pEC50	=	6.3	6.3	19	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	11253485	141978	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	204	0	2	3	0.5	O=C1c2c(O)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL387344	141978	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	204	0	2	3	0.5	O=C1c2c(O)cccc2C2CNCCN12	10.1021/jm0612968
	118733826	120643	None	0	Human	Functional	pEC50	=	6.3	6.3	5	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@@H]1C[C@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416066	120643	None	0	Human	Functional	pEC50	=	6.3	6.3	5	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@@H]1C[C@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546874	120643	None	0	Human	Functional	pEC50	=	6.3	6.3	5	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	227	5	1	2	2.2	NC[C@@H]1C[C@H]1c1cc(F)ccc1OCCF	10.1021/jm5019274
	44412308	166006	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@@H]3CNC[C@@H]32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL425423	166006	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@@H]3CNC[C@@H]32)n1	10.1016/j.bmcl.2006.03.007
	166	3359	None	18	Human	Functional	pEC50	=	7.3	7.3	-2	4	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	3045227	3359	None	18	Human	Functional	pEC50	=	7.3	7.3	-2	4	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	CHEMBL76781	3359	None	18	Human	Functional	pEC50	=	7.3	7.3	-2	4	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	137629973	161027	None	0	Human	Functional	pEC50	=	6.3	6.3	6	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	319	6	1	2	4.4	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1ccccc1Cl	10.1021/acs.jmedchem.7b00584
	CHEMBL4104218	161027	None	0	Human	Functional	pEC50	=	6.3	6.3	6	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	319	6	1	2	4.4	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1ccccc1Cl	10.1021/acs.jmedchem.7b00584
	CHEMBL4116381	161027	None	0	Human	Functional	pEC50	=	6.3	6.3	6	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	319	6	1	2	4.4	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1ccccc1Cl	10.1021/acs.jmedchem.7b00584
	137629588	161035	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	336	6	1	3	4.3	COc1ccc(F)cc1C1CC1CNCc1cccc2cccnc12	10.1021/acs.jmedchem.7b00584
	CHEMBL4064935	161035	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	336	6	1	3	4.3	COc1ccc(F)cc1C1CC1CNCc1cccc2cccnc12	10.1021/acs.jmedchem.7b00584
	CHEMBL4116446	161035	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	336	6	1	3	4.3	COc1ccc(F)cc1C1CC1CNCc1cccc2cccnc12	10.1021/acs.jmedchem.7b00584
	155516860	176531	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	179	2	1	1	2.1	Cc1cccc([C@]2(F)C[C@H]2CN)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4443782	176531	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	179	2	1	1	2.1	Cc1cccc([C@]2(F)C[C@H]2CN)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4597089	176531	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	179	2	1	1	2.1	Cc1cccc([C@]2(F)C[C@H]2CN)c1	10.1016/j.ejmech.2019.111626
	155516860	176531	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	179	2	1	1	2.1	Cc1cccc([C@]2(F)C[C@H]2CN)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4443782	176531	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	179	2	1	1	2.1	Cc1cccc([C@]2(F)C[C@H]2CN)c1	10.1016/j.ejmech.2019.111626
	CHEMBL4597089	176531	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	179	2	1	1	2.1	Cc1cccc([C@]2(F)C[C@H]2CN)c1	10.1016/j.ejmech.2019.111626
	137629973	161027	None	0	Human	Functional	pEC50	=	6.3	6.3	6	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	319	6	1	2	4.4	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1ccccc1Cl	10.1021/acs.jmedchem.7b00584
	CHEMBL4104218	161027	None	0	Human	Functional	pEC50	=	6.3	6.3	6	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	319	6	1	2	4.4	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1ccccc1Cl	10.1021/acs.jmedchem.7b00584
	CHEMBL4116381	161027	None	0	Human	Functional	pEC50	=	6.3	6.3	6	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	319	6	1	2	4.4	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCc1ccccc1Cl	10.1021/acs.jmedchem.7b00584
	16768198	200112	None	45	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	220	1	1	5	1.1	c1nc(N2CCNCC2)c2ccsc2n1	10.1016/j.bmcl.2009.10.112
	CHEMBL596108	200112	None	45	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	220	1	1	5	1.1	c1nc(N2CCNCC2)c2ccsc2n1	10.1016/j.bmcl.2009.10.112
	137629588	161035	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	336	6	1	3	4.3	COc1ccc(F)cc1C1CC1CNCc1cccc2cccnc12	10.1021/acs.jmedchem.7b00584
	CHEMBL4064935	161035	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	336	6	1	3	4.3	COc1ccc(F)cc1C1CC1CNCc1cccc2cccnc12	10.1021/acs.jmedchem.7b00584
	CHEMBL4116446	161035	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	336	6	1	3	4.3	COc1ccc(F)cc1C1CC1CNCc1cccc2cccnc12	10.1021/acs.jmedchem.7b00584
	137637650	156237	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2cncc3ccccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	CHEMBL4064770	156237	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	301	3	0	5	3.6	CCn1nc(-c2cncc3ccccc23)cc1-c1cccnn1	10.1021/acs.jmedchem.7b00385
	11233293	84162	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	310	1	1	2	2.9	CC1(c2cc3c(c(C(F)(F)F)c2)C(=O)N2CCNC[C@@H]32)CC1	10.1021/jm0612968
	CHEMBL220833	84162	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	310	1	1	2	2.9	CC1(c2cc3c(c(C(F)(F)F)c2)C(=O)N2CCNC[C@@H]32)CC1	10.1021/jm0612968
	16115392	84797	None	0	Human	Functional	pEC50	=	7.3	7.3	5	2	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223292	84797	None	0	Human	Functional	pEC50	=	7.3	7.3	5	2	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	44414183	168917	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Inhibition of 5HT2C assessed as intracellular calcium concentrationInhibition of 5HT2C assessed as intracellular calcium concentration	ChEMBL	207	0	1	1	2.8	C[C@H]1c2cc(Cl)ccc2[C@H]2CNC[C@H]21	10.1016/j.bmcl.2006.04.070
	CHEMBL438611	168917	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Inhibition of 5HT2C assessed as intracellular calcium concentrationInhibition of 5HT2C assessed as intracellular calcium concentration	ChEMBL	207	0	1	1	2.8	C[C@H]1c2cc(Cl)ccc2[C@H]2CNC[C@H]21	10.1016/j.bmcl.2006.04.070
	137628784	160991	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1ccc(F)cc1C1CC1CNCc1ccsc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4091197	160991	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1ccc(F)cc1C1CC1CNCc1ccsc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4116144	160991	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1ccc(F)cc1C1CC1CNCc1ccsc1OC	10.1021/acs.jmedchem.7b00584
	11324968	91085	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397880	91085	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	24826870	91103	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397898	91103	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	70693926	74459	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	217	5	1	2	2.5	NC[C@H]1C[C@@H]1c1ccccc1OCC1CC1	10.1021/ml200206z
	CHEMBL2022189	74459	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	217	5	1	2	2.5	NC[C@H]1C[C@@H]1c1ccccc1OCC1CC1	10.1021/ml200206z
	CHEMBL2027896	74459	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	217	5	1	2	2.5	NC[C@H]1C[C@@H]1c1ccccc1OCC1CC1	10.1021/ml200206z
	137628784	160991	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1ccc(F)cc1C1CC1CNCc1ccsc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4091197	160991	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1ccc(F)cc1C1CC1CNCc1ccsc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4116144	160991	None	0	Human	Functional	pEC50	=	6.3	6.3	-1	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	321	7	1	4	3.8	COc1ccc(F)cc1C1CC1CNCc1ccsc1OC	10.1021/acs.jmedchem.7b00584
	11171955	91093	None	0	Human	Functional	pEC50	=	7.3	7.3	4	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397888	91093	None	0	Human	Functional	pEC50	=	7.3	7.3	4	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	162660343	183703	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762474	183703	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803205	183703	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	45484827	196789	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	362	6	1	6	2.1	Cc1cc(=O)n(CCCOc2ccccc2Cl)c(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.133
	CHEMBL565531	196789	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	362	6	1	6	2.1	Cc1cc(=O)n(CCCOc2ccccc2Cl)c(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.133
	10472780	63283	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	2	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	345	3	1	2	4.3	CC1CNCCc2cc(OCc3ccccc3)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL179244	63283	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	2	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	345	3	1	2	4.3	CC1CNCCc2cc(OCc3ccccc3)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	162660343	183703	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762474	183703	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803205	183703	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	44572696	187259	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	1	3.6	c1ccc(CNC[C@H]2C[C@@H]2c2ccccc2)cc1	10.1021/jm801354e
	CHEMBL492698	187259	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	1	3.6	c1ccc(CNC[C@H]2C[C@@H]2c2ccccc2)cc1	10.1021/jm801354e
	44412388	78185	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210484	78185	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	3	Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsInduction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	53324327	56850	None	0	Human	Functional	pEC50	=	6.2	6.2	1	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643857	56850	None	0	Human	Functional	pEC50	=	6.2	6.2	1	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	137658409	159682	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	299	3	0	3	4.8	CCn1nc(-c2cccc3ccccc23)cc1-c1ccccn1	10.1021/acs.jmedchem.7b00385
	CHEMBL4104126	159682	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	299	3	0	3	4.8	CCn1nc(-c2cccc3ccccc23)cc1-c1ccccn1	10.1021/acs.jmedchem.7b00385
	137632069	156388	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	288	2	0	4	3.6	Cn1ccnc1-c1cc(-c2cccc3ccccc23)nn1C	10.1021/acs.jmedchem.7b00385
	CHEMBL4066433	156388	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	288	2	0	4	3.6	Cn1ccnc1-c1cc(-c2cccc3ccccc23)nn1C	10.1021/acs.jmedchem.7b00385
	11361103	91105	None	1	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2ccc(C(F)(F)F)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397900	91105	None	1	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	270	0	1	2	1.7	O=C1c2ccc(C(F)(F)F)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	11644842	89097	None	0	Human	Functional	pEC50	=	7.2	7.2	12	2	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337105	89097	None	0	Human	Functional	pEC50	=	7.2	7.2	12	2	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365394	89097	None	0	Human	Functional	pEC50	=	7.2	7.2	12	2	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	137659281	159257	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	296	2	0	3	4.0	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N(C)C	10.1021/acs.jmedchem.7b00385
	CHEMBL4099179	159257	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	296	2	0	3	4.0	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N(C)C	10.1021/acs.jmedchem.7b00385
	44404886	72225	None	0	Human	Functional	pEC50	=	6.2	6.2	-19	2	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay	ChEMBL	260	6	1	3	3.3	CCCCn1cc(CCN(C)C)c2c(O)cccc21	10.1016/j.bmcl.2005.06.104
	CHEMBL198124	72225	None	0	Human	Functional	pEC50	=	6.2	6.2	-19	2	Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay	ChEMBL	260	6	1	3	3.3	CCCCn1cc(CCN(C)C)c2c(O)cccc21	10.1016/j.bmcl.2005.06.104
	155539961	176548	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)cc1C1(F)CC1CN	10.1016/j.ejmech.2019.111626
	CHEMBL4515411	176548	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)cc1C1(F)CC1CN	10.1016/j.ejmech.2019.111626
	CHEMBL4597225	176548	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)cc1C1(F)CC1CN	10.1016/j.ejmech.2019.111626
	16115654	136974	None	0	Human	Functional	pEC50	=	8.2	8.2	27	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374562	136974	None	0	Human	Functional	pEC50	=	8.2	8.2	27	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	24826957	91117	None	0	Human	Functional	pEC50	=	8.2	8.2	24	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1ccc(C)c2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397912	91117	None	0	Human	Functional	pEC50	=	8.2	8.2	24	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1ccc(C)c2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	44572172	12546	None	0	Human	Functional	pEC50	=	8.2	8.2	-1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL1186686	12546	None	0	Human	Functional	pEC50	=	8.2	8.2	-1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL474633	12546	None	0	Human	Functional	pEC50	=	8.2	8.2	-1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	137652480	157154	None	0	Human	Functional	pEC50	=	8.2	8.2	12	2	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	349	3	1	4	3.1	Cn1nc(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4075267	157154	None	0	Human	Functional	pEC50	=	8.2	8.2	12	2	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	349	3	1	4	3.1	Cn1nc(-c2cccc3ccccc23)cc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	137646921	157700	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	366	3	1	4	4.1	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4081863	157700	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	366	3	1	4	4.1	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	11447552	62528	None	4	Human	Functional	pEC50	=	8.2	8.2	30	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL178231	62528	None	4	Human	Functional	pEC50	=	8.2	8.2	30	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	15984073	166071	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Inhibition of 5HT2C assessed as intracellular calcium concentrationInhibition of 5HT2C assessed as intracellular calcium concentration	ChEMBL	237	1	1	2	2.8	COc1cc2c(cc1Cl)[C@H](C)[C@@H]1CNC[C@H]21	10.1016/j.bmcl.2006.04.070
	CHEMBL425777	166071	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Inhibition of 5HT2C assessed as intracellular calcium concentrationInhibition of 5HT2C assessed as intracellular calcium concentration	ChEMBL	237	1	1	2	2.8	COc1cc2c(cc1Cl)[C@H](C)[C@@H]1CNC[C@H]21	10.1016/j.bmcl.2006.04.070
	162658689	183690	None	0	Human	Functional	pEC50	=	8.2	8.2	28	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183690	None	0	Human	Functional	pEC50	=	8.2	8.2	28	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183690	None	0	Human	Functional	pEC50	=	8.2	8.2	28	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	162658689	183690	None	0	Human	Functional	pEC50	=	8.2	8.2	28	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183690	None	0	Human	Functional	pEC50	=	8.2	8.2	28	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183690	None	0	Human	Functional	pEC50	=	8.2	8.2	28	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	134265637	181809	None	0	Human	Functional	pEC50	=	8.2	8.2	2	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	229	1	1	3	1.7	c1cc(C2CC2)c2c(n1)N1CCNC[C@H]1CC2	10.1016/j.bmcl.2021.127872
	CHEMBL4778104	181809	None	0	Human	Functional	pEC50	=	8.2	8.2	2	3	Agonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2CR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay	ChEMBL	229	1	1	3	1.7	c1cc(C2CC2)c2c(n1)N1CCNC[C@H]1CC2	10.1016/j.bmcl.2021.127872
	10105208	62499	None	0	Human	Functional	pEC50	=	8.2	8.2	15	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL178124	62499	None	0	Human	Functional	pEC50	=	8.2	8.2	15	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	9990808	122772	None	0	Human	Functional	pEC50	=	8.2	8.2	10	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	CHEMBL360492	122772	None	0	Human	Functional	pEC50	=	8.2	8.2	10	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	24773651	154857	None	0	Human	Functional	pEC50	=	8.2	8.2	5	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	CHEMBL400600	154857	None	0	Human	Functional	pEC50	=	8.2	8.2	5	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	134141127	147226	None	0	Human	Functional	pEC50	=	8.2	8.2	-3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	240	0	1	2	2.2	Fc1ccc2c(c1Cl)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3928388	147226	None	0	Human	Functional	pEC50	=	8.2	8.2	-3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	240	0	1	2	2.2	Fc1ccc2c(c1Cl)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	134149355	148123	None	0	Human	Functional	pEC50	=	8.2	8.2	31	3	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	322	2	1	4	2.7	c1cc(Cc2ccc3c(c2)OCO3)c2c(c1)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3935339	148123	None	0	Human	Functional	pEC50	=	8.2	8.2	31	3	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	322	2	1	4	2.7	c1cc(Cc2ccc3c(c2)OCO3)c2c(c1)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	162644827	183623	None	0	Human	Functional	pEC50	=	8.2	8.2	16	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183623	None	0	Human	Functional	pEC50	=	8.2	8.2	16	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183623	None	0	Human	Functional	pEC50	=	8.2	8.2	16	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	46230100	199319	None	0	Human	Functional	pEC50	=	8.2	8.2	38	2	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
	CHEMBL590531	199319	None	0	Human	Functional	pEC50	=	8.2	8.2	38	2	Agonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
	11708275	72712	None	3	Rat	Functional	pEC50	=	8.2	8.2	-1	2	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	CHEMBL199775	72712	None	3	Rat	Functional	pEC50	=	8.2	8.2	-1	2	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	11264955	204961	None	0	Human	Functional	pEC50	=	8.2	8.2	-1	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76474	204961	None	0	Human	Functional	pEC50	=	8.2	8.2	-1	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	162644827	183623	None	0	Human	Functional	pEC50	=	8.2	8.2	16	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183623	None	0	Human	Functional	pEC50	=	8.2	8.2	16	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183623	None	0	Human	Functional	pEC50	=	8.2	8.2	16	3	Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	118733790	120671	None	0	Human	Functional	pEC50	=	7.2	7.2	36	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416047	120671	None	0	Human	Functional	pEC50	=	7.2	7.2	36	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546973	120671	None	0	Human	Functional	pEC50	=	7.2	7.2	36	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	68690817	91084	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	227	0	1	3	0.5	N#Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397879	91084	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	227	0	1	3	0.5	N#Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	4305260	191025	None	1	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	288	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186877	191025	None	1	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	288	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	4305260	191025	None	1	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	288	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186877	191025	None	1	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	288	1	2	2	4.1	Clc1ccc2[nH]c3c(c2c1)CCNC3c1cccs1	10.1021/acsmedchemlett.1c00694
	155539961	176548	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)cc1C1(F)CC1CN	10.1016/j.ejmech.2019.111626
	CHEMBL4515411	176548	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)cc1C1(F)CC1CN	10.1016/j.ejmech.2019.111626
	CHEMBL4597225	176548	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	3	Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)cc1C1(F)CC1CN	10.1016/j.ejmech.2019.111626
	46230098	199329	None	0	Rat	Functional	pEC50	=	7.2	7.2	-30	4	Agonist activity at 5HT2C receptor in rat fundusAgonist activity at 5HT2C receptor in rat fundus	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590580	199329	None	0	Rat	Functional	pEC50	=	7.2	7.2	-30	4	Agonist activity at 5HT2C receptor in rat fundusAgonist activity at 5HT2C receptor in rat fundus	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	3071387	192770	None	1	Human	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5172342	192770	None	1	Human	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221228	192770	None	1	Human	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	122442273	138356	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138356	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138356	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	3071387	192770	None	1	Human	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5172342	192770	None	1	Human	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221228	192770	None	1	Human	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	216	1	3	2	2.5	CCC1NCCc2c1[nH]c1ccc(O)cc21	10.1021/acsmedchemlett.1c00694
	122442273	138356	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138356	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138356	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	68691189	91108	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	227	0	1	3	0.5	N#Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397903	91108	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	227	0	1	3	0.5	N#Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	137650864	161208	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	8	1	3	3.8	COc1ccccc1CCNCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4075150	161208	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	8	1	3	3.8	COc1ccccc1CCNCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4117857	161208	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	8	1	3	3.8	COc1ccccc1CCNCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	46228434	200146	None	2	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	254	1	1	5	1.8	Clc1nc(N2CCNCC2)nc2sccc12	10.1016/j.bmcl.2009.10.112
	CHEMBL596327	200146	None	2	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	254	1	1	5	1.8	Clc1nc(N2CCNCC2)nc2sccc12	10.1016/j.bmcl.2009.10.112
	137650864	161208	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	8	1	3	3.8	COc1ccccc1CCNCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4075150	161208	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	8	1	3	3.8	COc1ccccc1CCNCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4117857	161208	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	3	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	8	1	3	3.8	COc1ccccc1CCNCC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	57799321	89061	None	1	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337491	89061	None	1	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364961	89061	None	1	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2C receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	45484654	197669	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	235	3	1	4	1.0	CC(C)CCn1nc2c(cc1=O)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL571064	197669	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	235	3	1	4	1.0	CC(C)CCn1nc2c(cc1=O)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL4749189	214064	None	31	Human	Functional	pEC50	=	7.2	7.2	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802743	214064	None	31	Human	Functional	pEC50	=	7.2	7.2	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	11739217	137040	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	300	2	1	3	2.2	CCOc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374660	137040	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	300	2	1	3	2.2	CCOc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	118733794	120673	None	0	Human	Functional	pEC50	=	7.2	7.2	15	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416049	120673	None	0	Human	Functional	pEC50	=	7.2	7.2	15	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546975	120673	None	0	Human	Functional	pEC50	=	7.2	7.2	15	3	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	53324165	56801	None	0	Human	Functional	pEC50	=	7.2	7.2	2	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	CHEMBL1643674	56801	None	0	Human	Functional	pEC50	=	7.2	7.2	2	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	137654926	158701	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	350	3	1	4	3.6	Cc1nc(-c2cccc3ccccc23)oc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4093250	158701	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	350	3	1	4	3.6	Cc1nc(-c2cccc3ccccc23)oc1C(=O)N1CCC(CO)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4749189	214064	None	31	Human	Functional	pEC50	=	7.2	7.2	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4802743	214064	None	31	Human	Functional	pEC50	=	7.2	7.2	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1	10.1021/acsmedchemlett.1c00694
	134137441	142493	None	0	Human	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	230	2	1	2	2.4	CCCc1ccc2c(c1)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3890492	142493	None	0	Human	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	230	2	1	2	2.4	CCCc1ccc2c(c1)N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	134139670	146165	None	0	Human	Functional	pEC50	=	7.2	7.2	7	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	216	0	1	2	2.2	c1ccc2c(c1)CC[C@@H]1CCNCCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3919861	146165	None	0	Human	Functional	pEC50	=	7.2	7.2	7	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	216	0	1	2	2.2	c1ccc2c(c1)CC[C@@H]1CCNCCCN21	10.1016/j.bmcl.2016.11.016
	15640062	148374	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	202	0	1	2	1.7	Cc1cccc2c1N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	CHEMBL3937394	148374	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	202	0	1	2	1.7	Cc1cccc2c1N1CCNCC1CC2	10.1016/j.bmcl.2016.11.016
	132820209	150241	None	0	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	232	1	1	3	1.8	COc1ccc2c(c1)CC[C@@H]1CNCCCN21	10.1016/j.bmcl.2016.11.016
	CHEMBL3952329	150241	None	0	Human	Functional	pEC50	=	6.2	6.2	1	2	Agonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at unedited 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting	ChEMBL	232	1	1	3	1.8	COc1ccc2c(c1)CC[C@@H]1CNCCCN21	10.1016/j.bmcl.2016.11.016
	10679289	207210	None	2	Rat	Functional	pEC50	=	6.2	6.2	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	192	2	1	2	2.1	CC(N)Cn1ccc2ccc(F)cc21	10.1021/jm970030l
	CHEMBL92656	207210	None	2	Rat	Functional	pEC50	=	6.2	6.2	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	192	2	1	2	2.1	CC(N)Cn1ccc2ccc(F)cc21	10.1021/jm970030l
	19036356	207278	None	0	Rat	Functional	pEC50	=	6.2	6.2	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	230	2	1	2	2.5	CC(N)Cn1ccc2c1-c1cc(F)ccc1C2	10.1021/jm970030l
	CHEMBL93154	207278	None	0	Rat	Functional	pEC50	=	6.2	6.2	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	230	2	1	2	2.5	CC(N)Cn1ccc2c1-c1cc(F)ccc1C2	10.1021/jm970030l
	10705346	207932	None	0	Rat	Functional	pEC50	=	5.2	5.2	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	242	3	1	3	2.4	COc1cccc2c1-c1c(ccn1CC(C)N)C2	10.1021/jm970030l
	CHEMBL96876	207932	None	0	Rat	Functional	pEC50	=	5.2	5.2	-	1	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the ratEfficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	ChEMBL	242	3	1	3	2.4	COc1cccc2c1-c1c(ccn1CC(C)N)C2	10.1021/jm970030l
	44573155	189159	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	280	4	2	3	1.1	O=S(=O)(NCC1CC1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL511044	189159	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	280	4	2	3	1.1	O=S(=O)(NCC1CC1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	10898996	187260	None	2	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	3	1	1	2.0	CNC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL492700	187260	None	2	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	3	1	1	2.0	CNC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	58911579	91096	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	242	1	1	2	1.5	O=C1c2c(cccc2C2CC2)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397891	91096	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	242	1	1	2	1.5	O=C1c2c(cccc2C2CC2)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	45484946	196765	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	380	4	1	5	2.4	C[C@@H]1CNCCN1c1cc(=O)n(C)c(CCc2ccccc2C(F)(F)F)n1	10.1016/j.bmcl.2009.07.133
	CHEMBL565351	196765	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as calcium mobilisation by FLIPR assay	ChEMBL	380	4	1	5	2.4	C[C@@H]1CNCCN1c1cc(=O)n(C)c(CCc2ccccc2C(F)(F)F)n1	10.1016/j.bmcl.2009.07.133
	18735305	204933	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76301	204933	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	3	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	118733760	120638	None	1	Human	Functional	pEC50	=	6.2	6.2	3	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416032	120638	None	1	Human	Functional	pEC50	=	6.2	6.2	3	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546869	120638	None	1	Human	Functional	pEC50	=	6.2	6.2	3	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	53317923	56846	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643853	56846	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	3	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	156013985	177175	None	0	Human	Functional	pEC50	=	7.2	7.2	18	2	Agonist activity at recombinant human 5HT2C receptor expressed in CHO cells assessed as accumulation of inositol phosphate measured after 30 mins in presence of [3H]inositol by scintillation counter methodAgonist activity at recombinant human 5HT2C receptor expressed in CHO cells assessed as accumulation of inositol phosphate measured after 30 mins in presence of [3H]inositol by scintillation counter method	ChEMBL	230	0	1	2	1.8	C1=CC2CNCCN3C[C@@H]4CCC[C@@H]4C(=C1)C23	10.1016/j.bmcl.2019.126929
	CHEMBL4634785	177175	None	0	Human	Functional	pEC50	=	7.2	7.2	18	2	Agonist activity at recombinant human 5HT2C receptor expressed in CHO cells assessed as accumulation of inositol phosphate measured after 30 mins in presence of [3H]inositol by scintillation counter methodAgonist activity at recombinant human 5HT2C receptor expressed in CHO cells assessed as accumulation of inositol phosphate measured after 30 mins in presence of [3H]inositol by scintillation counter method	ChEMBL	230	0	1	2	1.8	C1=CC2CNCCN3C[C@@H]4CCC[C@@H]4C(=C1)C23	10.1016/j.bmcl.2019.126929
	168282376	192886	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5189339	192886	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222002	192886	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168282376	192886	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5189339	192886	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222002	192886	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	46228435	200147	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	218	1	1	5	0.9	Cc1cc2c(N3CCNCC3)ncnc2o1	10.1016/j.bmcl.2009.10.112
	CHEMBL596328	200147	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity against human 5HT2C receptor by FLIPR assayAgonist activity against human 5HT2C receptor by FLIPR assay	ChEMBL	218	1	1	5	0.9	Cc1cc2c(N3CCNCC3)ncnc2o1	10.1016/j.bmcl.2009.10.112
	45484681	197095	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	280	2	1	5	0.9	N#Cc1ccc(Cn2nc3c(cc2=O)CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	CHEMBL567587	197095	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	280	2	1	5	0.9	N#Cc1ccc(Cn2nc3c(cc2=O)CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	118733780	120640	None	0	Human	Functional	pEC50	=	6.2	6.2	7	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416042	120640	None	0	Human	Functional	pEC50	=	6.2	6.2	7	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546871	120640	None	0	Human	Functional	pEC50	=	6.2	6.2	7	2	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	137630996	161139	None	0	Human	Functional	pEC50	=	6.2	6.2	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	7	0	3	4.1	COc1ccccc1CN(C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4079976	161139	None	0	Human	Functional	pEC50	=	6.2	6.2	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	7	0	3	4.1	COc1ccccc1CN(C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4117263	161139	None	0	Human	Functional	pEC50	=	6.2	6.2	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	7	0	3	4.1	COc1ccccc1CN(C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	137630996	161139	None	0	Human	Functional	pEC50	=	6.2	6.2	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	7	0	3	4.1	COc1ccccc1CN(C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4079976	161139	None	0	Human	Functional	pEC50	=	6.2	6.2	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	7	0	3	4.1	COc1ccccc1CN(C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	CHEMBL4117263	161139	None	0	Human	Functional	pEC50	=	6.2	6.2	3	2	Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay	ChEMBL	329	7	0	3	4.1	COc1ccccc1CN(C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.7b00584
	137646111	157918	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	356	2	1	4	3.7	O=C(c1csc(-c2cccc(Cl)c2Cl)n1)N1CCC(O)CC1	10.1021/acs.jmedchem.7b00385
	CHEMBL4084377	157918	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	356	2	1	4	3.7	O=C(c1csc(-c2cccc(Cl)c2Cl)n1)N1CCC(O)CC1	10.1021/acs.jmedchem.7b00385
	137660422	159172	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	374	2	1	4	4.2	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCc2[nH]cnc2C1	10.1021/acs.jmedchem.7b00385
	CHEMBL4098357	159172	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	374	2	1	4	4.2	Cc1nc(-c2cccc3ccccc23)sc1C(=O)N1CCc2[nH]cnc2C1	10.1021/acs.jmedchem.7b00385
	10017556	161878	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.5	CC(C)Oc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL415029	161878	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.5	CC(C)Oc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	168286640	192928	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194223	192928	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222252	192928	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4802359	214062	None	1	Human	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	118733768	120646	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	253	6	1	2	3.6	CCCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416036	120646	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	253	6	1	2	3.6	CCCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546891	120646	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	253	6	1	2	3.6	CCCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL4795286	214072	None	0	Human	Functional	pEC50	=	6.2	6.2	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803900	214072	None	0	Human	Functional	pEC50	=	6.2	6.2	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	44431699	88289	None	0	Rat	Functional	pEC50	=	6.2	6.2	-5	2	Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	315	4	1	6	1.7	Cc1noc(Cc2c3c(c(C[C@@H](C)N)c4c2OCC4)OCC3)n1	10.1016/j.bmcl.2007.03.073
	CHEMBL234837	88289	None	0	Rat	Functional	pEC50	=	6.2	6.2	-5	2	Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	315	4	1	6	1.7	Cc1noc(Cc2c3c(c(C[C@@H](C)N)c4c2OCC4)OCC3)n1	10.1016/j.bmcl.2007.03.073
	168286640	192928	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194223	192928	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222252	192928	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4802359	214062	None	1	Human	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Clc1ccc2[nH]c3c(c2c1)CCNC3c1ccccc1	10.1021/acsmedchemlett.1c00694
	CHEMBL4795286	214072	None	0	Human	Functional	pEC50	=	6.2	6.2	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL4803900	214072	None	0	Human	Functional	pEC50	=	6.2	6.2	4	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL		None	None	None		Oc1cccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	44572256	12553	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	241	3	1	1	3.6	NC[C@H]1C[C@@H]1c1cccc(-c2ccc(F)cc2)c1	10.1021/jm801354e
	CHEMBL1186705	12553	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	241	3	1	1	3.6	NC[C@H]1C[C@@H]1c1cccc(-c2ccc(F)cc2)c1	10.1021/jm801354e
	CHEMBL474950	12553	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	241	3	1	1	3.6	NC[C@H]1C[C@@H]1c1cccc(-c2ccc(F)cc2)c1	10.1021/jm801354e
	44573217	187339	None	0	Human	Functional	pEC50	=	6.2	6.2	-10	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	302	3	2	3	2.2	O=S(=O)(Nc1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL493152	187339	None	0	Human	Functional	pEC50	=	6.2	6.2	-10	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	302	3	2	3	2.2	O=S(=O)(Nc1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	11221167	84680	None	0	Human	Functional	pEC50	=	8.2	8.2	25	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL222514	84680	None	0	Human	Functional	pEC50	=	8.2	8.2	25	3	Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	44572178	12561	None	0	Human	Functional	pEC50	=	8.2	8.2	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL1186736	12561	None	0	Human	Functional	pEC50	=	8.2	8.2	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL475642	12561	None	0	Human	Functional	pEC50	=	8.2	8.2	1	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	44573229	172676	None	0	Human	Functional	pEC50	=	8.2	8.2	2	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc2c(c1)CCNCC2)c1ccccc1F	10.1016/j.bmcl.2009.02.071
	CHEMBL449999	172676	None	0	Human	Functional	pEC50	=	8.2	8.2	2	2	Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc2c(c1)CCNCC2)c1ccccc1F	10.1016/j.bmcl.2009.02.071
	137641125	157010	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	316	3	1	6	3.2	CCn1nc(-c2cccc3ccncc23)cc1-c1ccc(N)nn1	10.1021/acs.jmedchem.7b00385
	CHEMBL4073363	157010	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2C receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay	ChEMBL	316	3	1	6	3.2	CCn1nc(-c2cccc3ccncc23)cc1-c1ccc(N)nn1	10.1021/acs.jmedchem.7b00385
	10105208	62499	None	0	Human	Functional	pEC50	=	8.2	8.2	15	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178124	62499	None	0	Human	Functional	pEC50	=	8.2	8.2	15	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	9990808	122772	None	0	Human	Functional	pEC50	=	8.2	8.2	10	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL360492	122772	None	0	Human	Functional	pEC50	=	8.2	8.2	10	3	Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	122442309	138347	None	0	Human	Functional	pEC50	=	8.1	8.1	4	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	138347	None	0	Human	Functional	pEC50	=	8.1	8.1	4	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	138347	None	0	Human	Functional	pEC50	=	8.1	8.1	4	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	135414348	72809	None	2	Rat	Functional	pEC50	=	8.1	8.1	1	2	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	CHEMBL200104	72809	None	2	Rat	Functional	pEC50	=	8.1	8.1	1	2	Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsActivity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	3906894	101979	None	24	Human	Functional	pEC50	=	8.1	8.1	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1021/jm301656h
	CHEMBL301466	101979	None	24	Human	Functional	pEC50	=	8.1	8.1	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1021/jm301656h
	122442309	138347	None	0	Human	Functional	pEC50	=	8.1	8.1	4	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	138347	None	0	Human	Functional	pEC50	=	8.1	8.1	4	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	138347	None	0	Human	Functional	pEC50	=	8.1	8.1	4	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	3906894	101979	None	24	Human	Functional	pEC50	=	8.1	8.1	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1021/jm301656h
	CHEMBL301466	101979	None	24	Human	Functional	pEC50	=	8.1	8.1	1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	271	0	2	3	1.7	O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12	10.1021/jm301656h
	134265675	164367	None	0	Human	Functional	pEC50	=	8.1	8.1	13	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	CHEMBL4212834	164367	None	0	Human	Functional	pEC50	=	8.1	8.1	13	3	Agonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2C receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	168273228	192799	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5178632	192799	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221423	192799	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	2	Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	354	4	3	5	3.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(O)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	11658860	2344	None	51	Human	Functional	pEC50	=	8.1	8.1	1	11	Agonist activity at recombinant human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate measured after 2 hrs in presence of [3H]inositol by scintillation counter methodAgonist activity at recombinant human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate measured after 2 hrs in presence of [3H]inositol by scintillation counter method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	2941	2344	None	51	Human	Functional	pEC50	=	8.1	8.1	1	11	Agonist activity at recombinant human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate measured after 2 hrs in presence of [3H]inositol by scintillation counter methodAgonist activity at recombinant human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate measured after 2 hrs in presence of [3H]inositol by scintillation counter method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	4374	2344	None	51	Human	Functional	pEC50	=	8.1	8.1	1	11	Agonist activity at recombinant human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate measured after 2 hrs in presence of [3H]inositol by scintillation counter methodAgonist activity at recombinant human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate measured after 2 hrs in presence of [3H]inositol by scintillation counter method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.1	8.1	1	11	Agonist activity at recombinant human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate measured after 2 hrs in presence of [3H]inositol by scintillation counter methodAgonist activity at recombinant human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate measured after 2 hrs in presence of [3H]inositol by scintillation counter method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.1	8.1	1	11	Agonist activity at recombinant human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate measured after 2 hrs in presence of [3H]inositol by scintillation counter methodAgonist activity at recombinant human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate measured after 2 hrs in presence of [3H]inositol by scintillation counter method	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	122442250	138344	None	0	Human	Functional	pEC50	=	8.1	8.1	8	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138344	None	0	Human	Functional	pEC50	=	8.1	8.1	8	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138344	None	0	Human	Functional	pEC50	=	8.1	8.1	8	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	12986494	198682	None	2	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	257	0	2	3	2.2	Clc1cc2c(cc1Cl)N1CCNCC1CN2	10.1016/s0960-894x(00)00400-5
	CHEMBL58009	198682	None	2	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressedAgonistic activity for 5-HT2c (5-HT2C) by measuring [3H]inositol monophosphate fromation in CHO cells in which the human 5-HT2C receptor subtype was stably expressed	ChEMBL	257	0	2	3	2.2	Clc1cc2c(cc1Cl)N1CCNCC1CN2	10.1016/s0960-894x(00)00400-5
	27559	203409	None	11	Human	Functional	pEC50	=	8.1	8.1	-1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	CHEMBL6557	203409	None	11	Human	Functional	pEC50	=	8.1	8.1	-1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	27559	203409	None	11	Human	Functional	pEC50	=	8.1	8.1	-1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	CHEMBL6557	203409	None	11	Human	Functional	pEC50	=	8.1	8.1	-1	2	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assayAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by fluorescence assay	ChEMBL	200	0	1	2	1.9	Cn1c2c(c3ccccc31)CCNCC2	10.1021/jm301656h
	122442250	138344	None	0	Human	Functional	pEC50	=	8.1	8.1	8	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138344	None	0	Human	Functional	pEC50	=	8.1	8.1	8	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138344	None	0	Human	Functional	pEC50	=	8.1	8.1	8	3	Agonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2C-INI receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	1355	2011	None	88	Human	Functional	pEC50	=	8.1	8.1	4	6	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	142	2011	None	88	Human	Functional	pEC50	=	8.1	8.1	4	6	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	CHEMBL478	2011	None	88	Human	Functional	pEC50	=	8.1	8.1	4	6	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	DB12110	2011	None	88	Human	Functional	pEC50	=	8.1	8.1	4	6	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	11658860	2344	None	51	Human	Functional	pEC50	=	8.1	8.1	1	11	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	2941	2344	None	51	Human	Functional	pEC50	=	8.1	8.1	1	11	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	4374	2344	None	51	Human	Functional	pEC50	=	8.1	8.1	1	11	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL360328	2344	None	51	Human	Functional	pEC50	=	8.1	8.1	1	11	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	DB04871	2344	None	51	Human	Functional	pEC50	=	8.1	8.1	1	11	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	11447552	62528	None	4	Human	Functional	pEC50	=	8.1	8.1	30	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL178231	62528	None	4	Human	Functional	pEC50	=	8.1	8.1	30	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	10036629	64637	None	0	Human	Functional	pEC50	=	8.1	8.1	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	CHEMBL181787	64637	None	0	Human	Functional	pEC50	=	8.1	8.1	7	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	24773816	94856	None	0	Human	Functional	pEC50	=	8.1	8.1	12	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253805	94856	None	0	Human	Functional	pEC50	=	8.1	8.1	12	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	24773895	94857	None	0	Human	Functional	pEC50	=	8.1	8.1	25	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL253806	94857	None	0	Human	Functional	pEC50	=	8.1	8.1	25	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	24773809	94882	None	0	Human	Functional	pEC50	=	8.1	8.1	15	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254009	94882	None	0	Human	Functional	pEC50	=	8.1	8.1	15	3	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	168273228	192799	None	0

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Main reference

Ligand source activities (1 row/activity)