Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Unit Assay Type Assay Description Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles
CHEMBL1223804 acm2_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
371 4 0 3 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL1223804 acm2_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
371 4 0 3 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL31599 acm2_human Human Yes 6.0 EC50 = 1000 Funct
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
549 15 0 4 3.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL31475 acm2_pig Pig No 5.0 EC50 = 10000 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
390 12 0 2 3.7 CC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O
CHEMBL7303 acm2_human Human Yes 5.0 EC50 = 10000 Funct
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL1169506 acm2_human Human No 6.0 EC50 = 1075 Funct
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
311 4 0 5 2.8 C1CN2CC1C(C2)C3=NSN=C3OCC#CC4=CC=CC=C4
CHEMBL100163 acm2_human Human No 6.0 EC50 = 1096 Funct
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
311 4 0 5 2.8 C1CN2CC1C(C2)C3=NSN=C3OCC#CC4=CC=CC=C4
CHEMBL327269 acm2_human Human No 8.0 EC50 = 11 Funct
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
311 4 0 5 2.8 C1CN2CC1C(C2)C3=NSN=C3OCC#CC4=CC=CC=C4
CHEMBL485913 acm2_human Human No 7.9 EC50 = 11.9 Funct
Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor
387 6 2 5 1.9 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CCOC(=O)N
CHEMBL491209 acm2_human Human No 7.9 EC50 = 11.9 Funct
Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor
372 4 1 4 2.8 CCOC(=O)N1CCC(CC1)N2CCC(CC2)N3C4=CC=CC=C4NC3=O
CHEMBL485913 acm2_human Human No 7.9 EC50 = 11.9 Funct
Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor
387 6 2 5 1.9 C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CCOC(=O)N
CHEMBL491209 acm2_human Human No 7.9 EC50 = 11.9 Funct
Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor
372 4 1 4 2.8 CCOC(=O)N1CCC(CC1)N2CCC(CC2)N3C4=CC=CC=C4NC3=O
CHEMBL27743 acm2_pig Pig No 6.9 EC50 = 114.8 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
618 15 0 4 5.1 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC(=C(C=C2C1=O)Cl)Cl)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL3618445 acm2_human Human No 6.9 EC50 = 118 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
496 6 3 4 3.9 CC(=NCC1=CC=CC=C1F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3618445 acm2_human Human No 6.9 EC50 = 118 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
496 6 3 4 3.9 CC(=NCC1=CC=CC=C1F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL312920 acm2_pig Pig No 5.9 EC50 = 1187 Funct
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
585 0 0 6 3.9 C1CN2CC3=CCOC4C5C3CC2C16C5N(C7C8C9CC1C2(C8N4C3=CC=CC=C32)CCN1CC9=CCO7)C1=CC=CC=C61
CHEMBL60101 acm2_human Human No 5.9 EC50 = 1210 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
344 4 0 5 3.2 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC=C(C=C5)Cl
CHEMBL31336 acm2_pig Pig No 4.9 EC50 = 12106.0 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
523 16 0 4 3.1 CC1C(C(=O)N(C1=O)CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)C(C(C2=O)C)C)C
CHEMBL1223806 acm2_human Human No 5.9 EC50 = 1258.9 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
358 3 0 4 3.6 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C
CHEMBL285598 acm2_pig Pig No 5.9 EC50 = 1258.9 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
669 19 0 4 7.1 CC(C)SC1C2=CC=CC=C2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(C4=CC=CC=C4C3=O)SC(C)C
CHEMBL303052 acm2_pig Pig No 5.9 EC50 = 1258.9 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
669 19 0 4 7.1 CC(C)SC1C2=CC=CC=C2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(C4=CC=CC=C4C3=O)SC(C)C
CHEMBL1223806 acm2_human Human No 5.9 EC50 = 1258.9 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
358 3 0 4 3.6 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C
CHEMBL285598 acm2_pig Pig No 5.9 EC50 = 1258.9 Funct
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
669 19 0 4 7.1 CC(C)SC1C2=CC=CC=C2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(C4=CC=CC=C4C3=O)SC(C)C
CHEMBL303052 acm2_pig Pig No 5.9 EC50 = 1258.9 Funct
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
669 19 0 4 7.1 CC(C)SC1C2=CC=CC=C2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(C4=CC=CC=C4C3=O)SC(C)C
CHEMBL1182747 acm2_pig Pig Yes 7.9 EC50 = 13.8 Funct
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
649 15 0 4 6.3 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC3=C2C(=CC=C3)C1=O)CCCN4C(=O)C5=CC=CC6=C5C(=CC=C6)C4=O
CHEMBL263972 acm2_pig Pig Yes 7.9 EC50 = 13.8 Funct
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
649 15 0 4 6.3 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC3=C2C(=CC=C3)C1=O)CCCN4C(=O)C5=CC=CC6=C5C(=CC=C6)C4=O
CHEMBL360055 acm2_pig Pig Yes 6.9 EC50 = 130 Funct
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
511 21 0 3 5.3 CC[N+](CC)(CC)CCOC1=C(C(=CC=C1)OCC[N+](CC)(CC)CC)OCC[N+](CC)(CC)CC
CHEMBL360055 acm2_pig Pig Yes 6.9 EC50 = 130 Funct
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
511 21 0 3 5.3 CC[N+](CC)(CC)CCOC1=C(C(=CC=C1)OCC[N+](CC)(CC)CC)OCC[N+](CC)(CC)CC
CHEMBL360055 acm2_pig Pig Yes 6.9 EC50 = 131.8 Funct
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
511 21 0 3 5.3 CC[N+](CC)(CC)CCOC1=C(C(=CC=C1)OCC[N+](CC)(CC)CC)OCC[N+](CC)(CC)CC
CHEMBL126655 acm2_human Human No 6.9 EC50 = 134.9 Funct
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
577 15 0 4 4.7 CC(C)(CN1C(=O)C2=CC=CC=C2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL168760 acm2_pig Pig No 5.9 EC50 = 1380.4 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
535 14 0 4 3.5 C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL286892 acm2_pig Pig No 5.9 EC50 = 1380.4 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
535 14 0 4 3.5 C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL99884 acm2_human Human No 6.9 EC50 = 139 Funct
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
327 4 0 5 3.4 C1CN2CC1C(C2)C3=NSN=C3SCC#CC4=CC=CC=C4
CHEMBL168760 acm2_pig Pig No 5.9 EC50 = 1390 Funct
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
535 14 0 4 3.5 C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL286892 acm2_pig Pig No 5.9 EC50 = 1390 Funct
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
535 14 0 4 3.5 C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL171721 acm2_human Human No 7.9 EC50 = 14 Funct
In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)
193 1 0 4 1.4 CC1=NOC(=N1)C2(CN3CCC2C3)C
CHEMBL31599 acm2_pig Pig Yes 5.8 EC50 = 1438.8 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
549 15 0 4 3.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL31380 acm2_pig Pig No 6.8 EC50 = 147.9 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
599 15 0 4 5.1 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC3=CC=CC=C3C=C2C1=O)CCCN4C(=O)C5=CC=CC=C5C4=O
CHEMBL60777 acm2_human Human No 5.8 EC50 = 1480 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
362 4 0 6 3.3 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC(=CC(=C5)Cl)F
CHEMBL30376 acm2_pig Pig No 5.8 EC50 = 1584.9 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
637 19 0 4 5.5 CC(C)OC1C2=CC=CC=C2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(C4=CC=CC=C4C3=O)OC(C)C
CHEMBL68151 acm2_pig Pig No 5.8 EC50 = 1584.9 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
637 19 0 4 5.5 CC(C)OC1C2=CC=CC=C2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(C4=CC=CC=C4C3=O)OC(C)C
CHEMBL30376 acm2_pig Pig No 5.8 EC50 = 1584.9 Funct
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
637 19 0 4 5.5 CC(C)OC1C2=CC=CC=C2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(C4=CC=CC=C4C3=O)OC(C)C
CHEMBL68151 acm2_pig Pig No 5.8 EC50 = 1584.9 Funct
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
637 19 0 4 5.5 CC(C)OC1C2=CC=CC=C2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(C4=CC=CC=C4C3=O)OC(C)C
CHEMBL64029 acm2_human Human No 5.8 EC50 = 1655 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
361 4 0 7 3.3 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC(=CC(=C5)F)F
CHEMBL203627 acm2_human Human No 4.8 EC50 = 16595.9 Funct
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer
373 4 0 2 3.1 CN(C)CC1=C2CN3C(=C(C4=CC=CC=C43)CN(C)C)CN2C5=CC=CC=C51
CHEMBL203627 acm2_human Human No 4.8 EC50 = 16595.9 Funct
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer
373 4 0 2 3.1 CN(C)CC1=C2CN3C(=C(C4=CC=CC=C43)CN(C)C)CN2C5=CC=CC=C51
CHEMBL126103 acm2_human Human No 6.8 EC50 = 169.8 Funct
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
577 15 0 4 4.6 CC1=CC2=C(C=C1)C(=O)N(C2=O)CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(=O)C4=C(C3=O)C=C(C=C4)C
CHEMBL3616500 acm2_human Human No 6.8 EC50 = 172 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
500 6 2 7 4.3 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)C(F)(F)F)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL3616500 acm2_human Human No 6.8 EC50 = 172 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
500 6 2 7 4.3 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)C(F)(F)F)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL126199 acm2_human Human No 6.8 EC50 = 177.8 Funct
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
605 15 0 4 5.5 CC(C)(CN1C(=O)C2=CC=CC=C2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN3C(=O)C4=CC=CC=C4C3=O
CHEMBL2024331 acm2_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay
400 5 1 4 3.6 CCOC(=O)N1C2CCC1CC(C2)N3CCCC(C3)NC(=O)C4=CC=CC=C4C
CHEMBL2024331 acm2_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay
400 5 1 4 3.6 CCOC(=O)N1C2CCC1CC(C2)N3CCCC(C3)NC(=O)C4=CC=CC=C4C
CHEMBL1223754 acm2_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
404 5 1 4 4.1 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)NC3=O
CHEMBL1223754 acm2_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
404 5 1 4 4.1 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)NC3=O
CHEMBL337676 acm2_human Human No 5.7 EC50 = 1900 Funct
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
179 2 1 4 0.2 CCN1N=C(N=N1)C2=CCCNC2
CHEMBL1180293 acm2_pig Pig No 8.7 EC50 = 2 Funct
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
667 6 2 4 3.1 C=CC[N+]12CCC34C1CC(C(=CCO)C2)C5=CN6C7C(=CN(C53)C8=CC=CC=C48)C9CC1C7(CC[N+]1(CC9=CCO)CC=C)C1=CC=CC=C16
CHEMBL1180293 acm2_pig Pig No 8.7 EC50 = 2 Funct
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
667 6 2 4 3.1 C=CC[N+]12CCC34C1CC(C(=CCO)C2)C5=CN6C7C(=CN(C53)C8=CC=CC=C48)C9CC1C7(CC[N+]1(CC9=CCO)CC=C)C1=CC=CC=C16
CHEMBL100147 acm2_human Human No 8.7 EC50 = 2 Funct
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
341 4 0 5 3.7 C1CC2CN(C1)CC2C3=NSN=C3SCC#CC4=CC=CC=C4
CHEMBL3618446 acm2_human Human No 6.7 EC50 = 211 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
510 7 3 4 4.2 CC(=NCCC1=CC=C(C=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3618446 acm2_human Human No 6.7 EC50 = 211 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
510 7 3 4 4.2 CC(=NCCC1=CC=C(C=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL30361 acm2_pig Pig No 5.7 EC50 = 2197.9 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
571 16 0 4 3.3 C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)C2CC=CCC2C1=O)CCCN3C(=O)C4CC=CCC4C3=O
CHEMBL319109 acm2_human Human No 5.7 EC50 = 2253 Funct
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
325 4 0 5 3.2 C1CC2CN(C1)CC2C3=NSN=C3OCC#CC4=CC=CC=C4
CHEMBL60833 acm2_human Human No 5.6 EC50 = 2280 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
344 4 0 5 3.2 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC(=CC=C5)Cl
CHEMBL285136 acm2_pig Pig No 5.6 EC50 = 2344.2 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
550 15 0 5 3.1 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)C4=C(C3=O)N=CC=C4
CHEMBL31533 acm2_pig Pig No 4.6 EC50 = 23988.3 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
333 10 1 3 2.6 C[N+](C)(CCCCCCO)CCCN1C(=O)C2=CC=CC=C2C1=O
CHEMBL3616504 acm2_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
442 3 2 3 2.9 CN1CCCCC1=NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3616504 acm2_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
442 3 2 3 2.9 CN1CCCCC1=NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL291351 acm2_human Human No 6.6 EC50 = 240 Funct
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
311 4 0 5 2.8 CN1CCC=C(C1)C2=NSN=C2OCC#CC3=CC=CC=C3
CHEMBL291351 acm2_human Human No 6.6 EC50 = 241 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
311 4 0 5 2.8 CN1CCC=C(C1)C2=NSN=C2OCC#CC3=CC=CC=C3
CHEMBL3618449 acm2_human Human No 6.6 EC50 = 242 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
450 6 2 5 3.5 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)F)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL3618449 acm2_human Human No 6.6 EC50 = 242 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
450 6 2 5 3.5 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)F)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL7303 acm2_human Human Yes 7.6 EC50 = 25 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL1223864 acm2_human Human No 5.6 EC50 = 2511.9 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
437 5 0 6 2.9 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL1223941 acm2_human Human No 5.6 EC50 = 2511.9 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
414 6 0 6 2.9 CC1(CCC(CC1)OCCOC)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL1223863 acm2_human Human No 5.6 EC50 = 2511.9 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
383 4 0 5 3.4 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL1223864 acm2_human Human No 5.6 EC50 = 2511.9 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
437 5 0 6 2.9 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL1223941 acm2_human Human No 5.6 EC50 = 2511.9 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
414 6 0 6 2.9 CC1(CCC(CC1)OCCOC)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL1223863 acm2_human Human No 5.6 EC50 = 2511.9 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
383 4 0 5 3.4 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)C#N)OC3=O
CHEMBL32688 acm2_pig Pig No 4.6 EC50 = 26000 Funct
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
324 6 0 2 4.6 CCC[N+]1=CC=C(C=C1)C=NOCC2=C(C=CC=C2Cl)Cl
CHEMBL81878 acm2_human Human No 4.6 EC50 = 26700 Funct
Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells
270 4 0 4 2.4 COC1=CC=CC(=C1)C#CCON=C2CN3CCC2C3
CHEMBL291872 acm2_human Human No 5.6 EC50 = 2690 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
345 4 0 7 2.7 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC(=CC(=C5)F)F
CHEMBL133905 acm2_human Human No 6.6 EC50 = 270 Funct
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
178 2 1 3 0.3 CCN1N=CC(=N1)C2=CCCNC2
CHEMBL503735 acm2_rat Rat Yes 5.6 EC50 = 2800 Funct
Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL503735 acm2_rat Rat Yes 5.6 EC50 = 2800 Funct
Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL81878 acm2_human Human No 4.6 EC50 = 28000 Funct
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
270 4 0 4 2.4 COC1=CC=CC(=C1)C#CCON=C2CN3CCC2C3
CHEMBL503735 acm2_rat Rat Yes 5.6 EC50 = 2840 Funct
Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL503735 acm2_rat Rat Yes 5.6 EC50 = 2840 Funct
Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
340 2 0 5 3.9 C1=CC2=C(C(=C1)Cl)N(C(=O)C2=O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL98255 acm2_human Human No 7.5 EC50 = 29 Funct
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
325 4 0 5 3.2 C1CC2CN(C1)CC2C3=NSN=C3OCC#CC4=CC=CC=C4
CHEMBL131428 acm2_human Human Yes 6.5 EC50 = 296 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
193 2 0 4 0.7 CCN1N=C(N=N1)C2=CCCN(C2)C
CHEMBL131428 acm2_human Human Yes 6.5 EC50 = 296 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
193 2 0 4 0.7 CCN1N=C(N=N1)C2=CCCN(C2)C
CHEMBL6966 acm2_pig Pig Yes 4.5 EC50 = 30974.2 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
455 13 0 6 3.8 CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
CHEMBL31221 acm2_pig Pig No 4.5 EC50 = 31989.0 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
495 16 0 4 2.0 CC1CC(=O)N(C1=O)CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)CC(C2=O)C
CHEMBL285811 acm2_pig Pig No 6.5 EC50 = 323.6 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
563 15 0 4 4.2 CC1=CC2=C(C=C1)C(=O)N(C2=O)CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL285811 acm2_human Human No 6.5 EC50 = 323.6 Funct
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
563 15 0 4 4.2 CC1=CC2=C(C=C1)C(=O)N(C2=O)CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL3618448 acm2_human Human No 6.5 EC50 = 342 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
524 7 2 4 4.5 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)Br)O)C=C1)N(C)CCC4=CC=C(C=C4)F
CHEMBL3618448 acm2_human Human No 6.5 EC50 = 342 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
524 7 2 4 4.5 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)Br)O)C=C1)N(C)CCC4=CC=C(C=C4)F
CHEMBL124330 acm2_human Human No 7.4 EC50 = 36.3 Funct
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
605 15 0 4 5.4 CC1=CC2=C(C=C1)C(=O)N(C2=O)CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN3C(=O)C4=C(C3=O)C=C(C=C4)C
CHEMBL28407 acm2_pig Pig Yes 6.4 EC50 = 389.1 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
563 16 0 4 4.4 C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL1223862 acm2_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
389 5 0 5 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)OC)OC3=O
CHEMBL284962 acm2_pig Pig No 6.4 EC50 = 398.1 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
665 15 0 4 5.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)CC4C5=CC=CC=C5C(C3=O)C6=CC=CC=C46
CHEMBL1223862 acm2_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
389 5 0 5 3.6 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)OC)OC3=O
CHEMBL273308 acm2_human Human Yes 6.4 EC50 = 400 Funct
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
210 1 0 3 -0.1 CCN1C(=O)CC2(C1=O)CCN(CC2)C
CHEMBL3337861 acm2_pig Pig No 6.4 EC50 = 407.4 Funct
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
573 3 1 5 4.4 CCC1CN2CCC34C2CC1C5=CN6C7C(=CN(C53)C8=CC=CC=C48)C9CC1C7(CCN1CC9CCO)C1=CC=CC=C16
CHEMBL3337861 acm2_pig Pig No 6.4 EC50 = 407.4 Funct
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
573 3 1 5 4.4 CCC1CN2CCC34C2CC1C5=CN6C7C(=CN(C53)C8=CC=CC=C48)C9CC1C7(CCN1CC9CCO)C1=CC=CC=C16
CHEMBL69305 acm2_human Human No 7.4 EC50 = 41 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
182 2 1 4 0.7 CCOC1=NOC2=C1CNCCC2
CHEMBL3337861 acm2_pig Pig No 6.4 EC50 = 410 Funct
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
573 3 1 5 4.4 CCC1CN2CCC34C2CC1C5=CN6C7C(=CN(C53)C8=CC=CC=C48)C9CC1C7(CCN1CC9CCO)C1=CC=CC=C16
CHEMBL3616497 acm2_human Human No 6.4 EC50 = 411 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
522 8 3 4 4.1 CC(=NCCC1=CC=C(C=C1)OC)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3616497 acm2_human Human No 6.4 EC50 = 411 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
522 8 3 4 4.1 CC(=NCCC1=CC=C(C=C1)OC)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL304142 acm2_human Human Yes 7.4 EC50 = 43 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
168 1 1 4 0.3 COC1=NOC2=C1CNCCC2
CHEMBL3618444 acm2_human Human No 6.4 EC50 = 435 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
496 6 3 4 3.9 CC(=NCC1=CC(=CC=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3618444 acm2_human Human No 6.4 EC50 = 435 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
496 6 3 4 3.9 CC(=NCC1=CC(=CC=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL380352 acm2_pig Pig Yes 6.4 EC50 = 436 Funct
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
585 0 0 6 3.9 C1CN2CC3=CCOC4C5C3CC2C16C5N(C7C8C9CC1C2(C8N4C3=CC=CC=C32)CCN1CC9=CCO7)C1=CC=CC=C61
CHEMBL380352 acm2_pig Pig Yes 6.4 EC50 = 436 Funct
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
585 0 0 6 3.9 C1CN2CC3=CCOC4C5C3CC2C16C5N(C7C8C9CC1C2(C8N4C3=CC=CC=C32)CCN1CC9=CCO7)C1=CC=CC=C61
CHEMBL380352 acm2_human Human Yes 6.4 EC50 = 436.5 Funct
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer
585 0 0 6 3.9 C1CN2CC3=CCOC4C5C3CC2C16C5N(C7C8C9CC1C2(C8N4C3=CC=CC=C32)CCN1CC9=CCO7)C1=CC=CC=C61
CHEMBL380352 acm2_human Human Yes 6.4 EC50 = 436.5 Funct
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer
585 0 0 6 3.9 C1CN2CC3=CCOC4C5C3CC2C16C5N(C7C8C9CC1C2(C8N4C3=CC=CC=C32)CCN1CC9=CCO7)C1=CC=CC=C61
CHEMBL609382 acm2_pig Pig No 7.4 EC50 = 45.0 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
655 17 0 6 7.4 C1CCC(CC1)N(CCCCCCN(CCCN2C(=O)C3=CC=CC=C3C2=O)C4CCCCC4)CCCN5C(=O)C6=CC=CC=C6C5=O
CHEMBL203627 acm2_human Human No 6.4 EC50 = 446.7 Funct
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer
373 4 0 2 3.1 CN(C)CC1=C2CN3C(=C(C4=CC=CC=C43)CN(C)C)CN2C5=CC=CC=C51
CHEMBL203627 acm2_human Human No 6.4 EC50 = 446.7 Funct
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer
373 4 0 2 3.1 CN(C)CC1=C2CN3C(=C(C4=CC=CC=C43)CN(C)C)CN2C5=CC=CC=C51
CHEMBL286686 acm2_pig Pig No 5.4 EC50 = 4497.8 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
575 16 0 4 4.1 C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)C2CCCCC2C1=O)CCCN3C(=O)C4CCCCC4C3=O
CHEMBL33656 acm2_pig Pig No 5.4 EC50 = 4500 Funct
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
459 10 0 4 4.8 CON=CC1=CC=[N+](C=C1)CCC[N+]2=CC=C(C=C2)C=NOCC3=C(C=CC=C3Cl)Cl
CHEMBL32676 acm2_pig Pig No 6.3 EC50 = 457.1 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
585 15 0 6 4.0 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC(=C(C=C2C1=O)F)F)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL262632 acm2_human Human No 7.3 EC50 = 46.8 Funct
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
633 15 0 4 6.2 CC1=CC2=C(C=C1)C(=O)N(C2=O)CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN3C(=O)C4=C(C3=O)C=C(C=C4)C
CHEMBL3337865 acm2_pig Pig No 6.3 EC50 = 500 Funct
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
557 2 0 4 5.6 CCC1CN2CCC34C2CC1C5=CN6C7C(=CN(C53)C8=CC=CC=C48)C9CC1C7(CCN1CC9CC)C1=CC=CC=C16
CHEMBL1223860 acm2_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)OC3=O
CHEMBL3337865 acm2_pig Pig No 6.3 EC50 = 501.2 Funct
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
557 2 0 4 5.6 CCC1CN2CCC34C2CC1C5=CN6C7C(=CN(C53)C8=CC=CC=C48)C9CC1C7(CCN1CC9CC)C1=CC=CC=C16
CHEMBL1223860 acm2_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=C(C(=C4)C)F)OC3=O
CHEMBL3337865 acm2_pig Pig No 6.3 EC50 = 501.2 Funct
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
557 2 0 4 5.6 CCC1CN2CCC34C2CC1C5=CN6C7C(=CN(C53)C8=CC=CC=C48)C9CC1C7(CCN1CC9CC)C1=CC=CC=C16
CHEMBL31452 acm2_pig Pig No 6.3 EC50 = 524.8 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
605 19 0 4 6.0 C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL352323 acm2_pig Pig No 6.3 EC50 = 524.8 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
605 19 0 4 6.0 C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL60479 acm2_human Human No 6.3 EC50 = 528 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
394 4 0 5 4.3 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC(=CC(=C5)Cl)Cl
CHEMBL31452 acm2_pig Pig No 6.3 EC50 = 530 Funct
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
605 19 0 4 6.0 C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL352323 acm2_pig Pig No 6.3 EC50 = 530 Funct
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
605 19 0 4 6.0 C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL284672 acm2_pig Pig No 4.3 EC50 = 53951.1 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
317 9 0 2 4.2 CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O
CHEMBL122499 acm2_human Human No 7.3 EC50 = 55.0 Funct
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
591 15 0 4 5.0 CC1=CC2=C(C=C1)C(=O)N(C2=O)CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL2313377 acm2_human Human No 6.3 EC50 = 550 Funct
Positive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assayPositive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay
296 2 2 4 3.6 CC1=C2C(=C(SC2=NC(=C1Cl)C)C(=O)NC3CC3)N
CHEMBL609120 acm2_pig Pig No 7.2 EC50 = 60.0 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
683 17 0 6 8.1 CC1=CC2=C(C=C1)C(=O)N(C2=O)CCCN(CCCCCCN(CCCN3C(=O)C4=C(C3=O)C=C(C=C4)C)C5CCCCC5)C6CCCCC6
CHEMBL69306 acm2_human Human No 8.2 EC50 = 6.7 Funct
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
192 2 1 4 0.4 C#CCOC1=NOC2=C1CNCCC2
CHEMBL32609 acm2_pig Pig No 5.2 EC50 = 6000 Funct
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
430 9 0 3 6.0 COC1=CC=C(C=C1)CCC[N+]2=CC=C(C=C2)C=NOCC3=C(C=CC=C3Cl)Cl
CHEMBL31103 acm2_pig Pig No 5.2 EC50 = 6025.6 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
553 15 2 4 2.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(C2=CC=CC=C2C1=O)O)CCCN3C(C4=CC=CC=C4C3=O)O
CHEMBL68393 acm2_pig Pig No 5.2 EC50 = 6025.6 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
553 15 2 4 2.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(C2=CC=CC=C2C1=O)O)CCCN3C(C4=CC=CC=C4C3=O)O
CHEMBL31103 acm2_pig Pig No 5.2 EC50 = 6025.6 Funct
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
553 15 2 4 2.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(C2=CC=CC=C2C1=O)O)CCCN3C(C4=CC=CC=C4C3=O)O
CHEMBL68393 acm2_pig Pig No 5.2 EC50 = 6025.6 Funct
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
553 15 2 4 2.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(C2=CC=CC=C2C1=O)O)CCCN3C(C4=CC=CC=C4C3=O)O
CHEMBL3618447 acm2_human Human No 6.2 EC50 = 604 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
510 6 2 4 4.1 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)Br)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL3618447 acm2_human Human No 6.2 EC50 = 604 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
510 6 2 4 4.1 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)Br)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL99521 acm2_human Human Yes 7.2 EC50 = 62 Funct
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
325 4 0 5 3.2 C1CN2CCC1C(C2)C3=NSN=C3OCC#CC4=CC=CC=C4
CHEMBL134641 acm2_human Human Yes 7.2 EC50 = 62.1 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
193 2 0 4 1.0 CON=C(C#N)C1CN2CCC1CC2
CHEMBL134641 acm2_human Human Yes 7.2 EC50 = 62.1 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
193 2 0 4 1.0 CON=C(C#N)C1CN2CCC1CC2
CHEMBL1223803 acm2_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
385 5 0 3 4.2 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL30939 acm2_pig Pig No 7.2 EC50 = 63.1 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
599 15 0 4 5.1 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC3=C2C(=CC=C3)C1=O)CCCN4C(=O)C5=CC=CC=C5C4=O
CHEMBL1223803 acm2_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
385 5 0 3 4.2 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C(=O)CC4=C3C=C(C=C4)C
CHEMBL1223805 acm2_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
357 3 0 3 3.3 CC1=CC2=C(CC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C)C=C1
CHEMBL1223940 acm2_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
403 6 0 5 3.5 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OCCOC)C
CHEMBL1223753 acm2_human Human Yes 6.2 EC50 = 631.0 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL2146599 acm2_human Human Yes 6.2 EC50 = 631.0 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
315 2 1 3 2.7 CC1=CC2=C(C=C1)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL2146598 acm2_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
301 2 1 3 2.4 C1CN(CCC1N2C3=CC=CC=C3NC2=O)C4CCOCC4
CHEMBL1223805 acm2_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
357 3 0 3 3.3 CC1=CC2=C(CC(=O)N2C3CCN(CC3)C4(CCC(CC4)OC)C)C=C1
CHEMBL1223940 acm2_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
403 6 0 5 3.5 CC1=CC2=C(C=C1)OC(=O)N2C3CCN(CC3)C4(CCC(CC4)OCCOC)C
CHEMBL1223753 acm2_human Human Yes 6.2 EC50 = 631.0 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL2146599 acm2_human Human Yes 6.2 EC50 = 631.0 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
315 2 1 3 2.7 CC1=CC2=C(C=C1)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL2146598 acm2_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay
301 2 1 3 2.4 C1CN(CCC1N2C3=CC=CC=C3NC2=O)C4CCOCC4
CHEMBL95 acm2_pig Pig Yes 5.2 EC50 = 6300 Funct
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
198 0 1 2 2.7 C1CCC2=NC3=CC=CC=C3C(=C2C1)N
CHEMBL95 acm2_pig Pig Yes 5.2 EC50 = 6300 Funct
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
198 0 1 2 2.7 C1CCC2=NC3=CC=CC=C3C(=C2C1)N
CHEMBL95 acm2_pig Pig Yes 5.2 EC50 = 6309.6 Funct
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
198 0 1 2 2.7 C1CCC2=NC3=CC=CC=C3C(=C2C1)N
CHEMBL2313377 acm2_rat Rat No 6.2 EC50 = 640 Funct
Positive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine responsePositive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine response
296 2 2 4 3.6 CC1=C2C(=C(SC2=NC(=C1Cl)C)C(=O)NC3CC3)N
CHEMBL3616499 acm2_human Human No 7.2 EC50 = 65.4 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
446 6 2 4 3.7 CC1=CC=C(C=C1)C(=O)NC2C(CC3=C2C=C(C=C3)N=C(C)N(C)CC4=CC=C(C=C4)F)O
CHEMBL3616499 acm2_human Human No 7.2 EC50 = 65.4 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
446 6 2 4 3.7 CC1=CC=C(C=C1)C(=O)NC2C(CC3=C2C=C(C=C3)N=C(C)N(C)CC4=CC=C(C=C4)F)O
CHEMBL3618450 acm2_human Human No 7.2 EC50 = 65.5 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
466 6 2 4 4.0 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)Cl)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL3618450 acm2_human Human No 7.2 EC50 = 65.5 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
466 6 2 4 4.0 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)Cl)O)C=C1)N(C)CC4=CC=C(C=C4)F
CHEMBL31376 acm2_pig Pig No 7.2 EC50 = 66.1 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
697 17 0 2 8.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=CC2=CC=CC=C2)C3=CC=CC=C3C1=O)CCCN4C(=CC5=CC=CC=C5)C6=CC=CC=C6C4=O
CHEMBL303360 acm2_human Human No 6.2 EC50 = 673 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
360 4 0 5 3.7 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC(=CC=C5)Cl
CHEMBL131777 acm2_human Human No 6.2 EC50 = 680 Funct
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
192 3 1 3 1.1 C=CCN1N=CC(=N1)C2CCCNC2
CHEMBL304247 acm2_human Human No 6.2 EC50 = 683 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
327 4 0 6 2.6 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC(=CC=C5)F
CHEMBL3616501 acm2_human Human Yes 6.2 EC50 = 693 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
508 7 2 4 5.0 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)C4=CC=CC=C4)O)C=C1)N(C)CC5=CC=C(C=C5)F
CHEMBL3616501 acm2_human Human Yes 6.2 EC50 = 693 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
508 7 2 4 5.0 CC(=NC1=CC2=C(CC(C2NC(=O)C3=CC=C(C=C3)C4=CC=CC=C4)O)C=C1)N(C)CC5=CC=C(C=C5)F
CHEMBL32530 acm2_pig Pig No 7.2 EC50 = 70.8 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
697 17 0 2 8.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=CC2=CC=CC=C2)C3=CC=CC=C3C1=O)CCCN4C(=CC5=CC=CC=C5)C6=CC=CC=C6C4=O
CHEMBL68936 acm2_pig Pig No 7.2 EC50 = 70.8 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
697 17 0 2 8.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=CC2=CC=CC=C2)C3=CC=CC=C3C1=O)CCCN4C(=CC5=CC=CC=C5)C6=CC=CC=C6C4=O
CHEMBL127933 acm2_human Human No 7.2 EC50 = 70.8 Funct
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
591 15 0 4 5.0 CC1=CC2=C(C=C1)C(=O)N(C2=O)CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN3C(=O)C4=CC=CC=C4C3=O
CHEMBL32530 acm2_pig Pig No 7.2 EC50 = 70.8 Funct
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
697 17 0 2 8.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=CC2=CC=CC=C2)C3=CC=CC=C3C1=O)CCCN4C(=CC5=CC=CC=C5)C6=CC=CC=C6C4=O
CHEMBL68936 acm2_pig Pig No 7.2 EC50 = 70.8 Funct
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
697 17 0 2 8.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=CC2=CC=CC=C2)C3=CC=CC=C3C1=O)CCCN4C(=CC5=CC=CC=C5)C6=CC=CC=C6C4=O
CHEMBL3618440 acm2_human Human No 7.1 EC50 = 71.8 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
496 6 3 4 3.9 CC(=NCC1=CC=C(C=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3618440 acm2_human Human No 7.1 EC50 = 71.8 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
496 6 3 4 3.9 CC(=NCC1=CC=C(C=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL609124 acm2_pig Pig No 6.1 EC50 = 739.6 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
597 19 0 8 3.2 C1=CC=C2C(=C1)C(=O)N(C2=O)CCCN(CCCCCCN(CCCN3C(=O)C4=CC=CC=C4C3=O)CCC#N)CCC#N
CHEMBL284055 acm2_pig Pig No 6.1 EC50 = 741.3 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
703 17 2 4 7.5 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(NC(=O)C2=CC=CC=C21)C3=CC=CC=C3)CCCN4C(NC(=O)C5=CC=CC=C54)C6=CC=CC=C6
CHEMBL3618436 acm2_human Human No 6.1 EC50 = 749 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
482 5 3 4 4.0 CC(=NC1=CC=C(C=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL3618436 acm2_human Human No 6.1 EC50 = 749 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
482 5 3 4 4.0 CC(=NC1=CC=C(C=C1)F)NC2=CC3=C(CC(C3NC(=O)C4=CC=C(C=C4)Br)O)C=C2
CHEMBL60331 acm2_human Human No 6.1 EC50 = 763 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
378 4 0 6 3.8 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC(=CC(=C5)Cl)F
CHEMBL60419 acm2_human Human No 6.1 EC50 = 779 Funct
Compound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells
309 4 0 5 2.5 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC=CC=C5
CHEMBL60419 acm2_human Human No 6.1 EC50 = 779 Funct
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
309 4 0 5 2.5 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC=CC=C5
CHEMBL294082 acm2_human Human No 6.1 EC50 = 791 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
327 4 0 6 2.6 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC=C(C=C5)F
CHEMBL1223861 acm2_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C(=CC(=C4)C)F)OC3=O
CHEMBL1223939 acm2_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.4 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL1223753 acm2_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL262124 acm2_pig Pig No 6.1 EC50 = 794.3 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
673 17 0 2 7.3 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(C2=CC=CC=C2C1=O)C3=CC=CC=C3)CCCN4C(C5=CC=CC=C5C4=O)C6=CC=CC=C6
CHEMBL303624 acm2_pig Pig No 6.1 EC50 = 794.3 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
673 17 0 2 7.3 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(C2=CC=CC=C2C1=O)C3=CC=CC=C3)CCCN4C(C5=CC=CC=C5C4=O)C6=CC=CC=C6
CHEMBL1223861 acm2_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
390 4 0 5 4.1 CCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C(=CC(=C4)C)F)OC3=O
CHEMBL1223939 acm2_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
451 6 0 6 3.4 CCCOC1CCC(CC1)(C)N2CCC(CC2)N3C4=C(C=CC(=C4)S(=O)(=O)C)OC3=O
CHEMBL1223753 acm2_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
333 2 1 4 2.2 CC1=CC2=C(C=C1F)NC(=O)N2C3CCN(CC3)C4CCOCC4
CHEMBL262124 acm2_pig Pig No 6.1 EC50 = 794.3 Funct
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
673 17 0 2 7.3 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(C2=CC=CC=C2C1=O)C3=CC=CC=C3)CCCN4C(C5=CC=CC=C5C4=O)C6=CC=CC=C6
CHEMBL303624 acm2_pig Pig No 6.1 EC50 = 794.3 Funct
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
673 17 0 2 7.3 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(C2=CC=CC=C2C1=O)C3=CC=CC=C3)CCCN4C(C5=CC=CC=C5C4=O)C6=CC=CC=C6
CHEMBL31097 acm2_pig Pig No 6.1 EC50 = 799.8 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
575 16 0 4 4.1 C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)C2CCCCC2C1=O)CCCN3C(=O)C4CCCCC4C3=O
CHEMBL60374 acm2_human Human No 7.1 EC50 = 80 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
360 4 0 5 3.7 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC=C(C=C5)Cl
CHEMBL418491 acm2_human Human No 7.1 EC50 = 83 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
343 4 0 6 3.2 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC=C(C=C5)F
CHEMBL7303 acm2_human Human Yes 7.1 EC50 = 83 Funct
In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL2111051 acm2_human Human Yes 6.1 EC50 = 849 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
165 2 0 2 0.8 C#CCOC1CN2CCC1CC2
CHEMBL2111051 acm2_human Human Yes 6.1 EC50 = 849 Funct
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
165 2 0 2 0.8 C#CCOC1CN2CCC1CC2
CHEMBL417560 acm2_human Human No 6.1 EC50 = 853 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
325 4 0 5 3.1 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC=CC=C5
CHEMBL293982 acm2_human Human No 6.0 EC50 = 904 Funct
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
343 4 0 6 3.2 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC(=CC=C5)F
CHEMBL32329 acm2_pig Pig No 5.0 EC50 = 9400 Funct
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
400 8 0 2 6.0 C1=CC=C(C=C1)CCC[N+]2=CC=C(C=C2)C=NOCC3=C(C=CC=C3Cl)Cl
CHEMBL177732 acm2_pig Pig No 5.0 EC50 = 9772.4 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
501 15 0 4 2.1 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2=CC=CC=C2C1=O)CCCN3C(=O)CCC3=O
CHEMBL609125 acm2_pig Pig No 6.0 EC50 = 990.8 Funct
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
727 23 0 6 8.4 C1=CC=C(C=C1)CCCN(CCCCCCN(CCCC2=CC=CC=C2)CCCN3C(=O)C4=CC=CC=C4C3=O)CCCN5C(=O)C6=CC=CC=C6C5=O
CHEMBL1201335 acm2_human Human Yes 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs
318 5 1 3 3.1 C[N+]1(CCC(C1)OC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C
CHEMBL1201335 acm2_human Human Yes 9.8 IC50 = 0.2 Funct
Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs
318 5 1 3 3.1 C[N+]1(CCC(C1)OC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C
CHEMBL564747 acm2_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
343 5 1 5 3.0 C1CN2CCC1C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CS4)O
CHEMBL564747 acm2_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
343 5 1 5 3.0 C1CN2CCC1C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CS4)O
CHEMBL562642 acm2_human Human No 9.6 IC50 = 0.2 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
335 5 1 5 3.1 C1CCC(C1)C(C2=CC=CS2)(C(=O)OC3CN4CCC3CC4)O
CHEMBL562642 acm2_human Human No 9.6 IC50 = 0.2 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
335 5 1 5 3.1 C1CCC(C1)C(C2=CC=CS2)(C(=O)OC3CN4CCC3CC4)O
CHEMBL551729 acm2_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
349 5 1 6 2.7 C1CN2CCC1C(C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O
CHEMBL556426 acm2_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
343 5 1 5 3.0 C1CN2CCC1C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CS4)O
CHEMBL551729 acm2_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
349 5 1 6 2.7 C1CN2CCC1C(C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O
CHEMBL556426 acm2_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
343 5 1 5 3.0 C1CN2CCC1C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CS4)O
CHEMBL216927 acm2_human Human Yes 9.3 IC50 = 0.5 Funct
Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation
488 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL216927 acm2_human Human Yes 9.3 IC50 = 0.5 Funct
Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation
488 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL554699 acm2_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
335 5 1 5 3.1 C1CCC(C1)C(C2=CC=CS2)(C(=O)OC3CN4CCC3CC4)O
CHEMBL554699 acm2_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
335 5 1 5 3.1 C1CCC(C1)C(C2=CC=CS2)(C(=O)OC3CN4CCC3CC4)O
CHEMBL335542 acm2_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells
553 16 0 13 1.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3C4=CCCN(C4)C
CHEMBL563887 acm2_human Human No 8.9 IC50 = 1.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
335 3 1 4 3.0 C1CN2CCC1C(C2)OC(=O)C3(C4=CC=CC=C4C5=CC=CC=C53)O
CHEMBL563887 acm2_human Human No 8.9 IC50 = 1.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
335 3 1 4 3.0 C1CN2CCC1C(C2)OC(=O)C3(C4=CC=CC=C4C5=CC=CC=C53)O
CHEMBL1289653 acm2_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
406 3 0 5 3.3 CC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC(=CC=C4)Cl
CHEMBL1289653 acm2_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
406 3 0 5 3.3 CC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC(=CC=C4)Cl
CHEMBL3401641 acm2_human Human No 8.8 IC50 = 1.7 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
348 4 2 5 2.1 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CS3)(C4=CC=CS4)O
CHEMBL3401641 acm2_human Human No 8.8 IC50 = 1.7 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
348 4 2 5 2.1 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CS3)(C4=CC=CS4)O
CHEMBL1779033 acm2_human Human No 8.7 IC50 = 1.8 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
342 5 0 4 3.5 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CS3)C4=CC=CC=C4
CHEMBL1779033 acm2_human Human No 8.8 IC50 = 1.8 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
342 5 0 4 3.5 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CS3)C4=CC=CC=C4
CHEMBL1289983 acm2_human Human No 8.0 IC50 = 10 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
434 4 0 5 4.1 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC(=CC=C4)Cl
CHEMBL1289983 acm2_human Human No 8.0 IC50 = 10 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
434 4 0 5 4.1 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC(=CC=C4)Cl
CHEMBL294082 acm2_rat Rat No 8.0 IC50 = 10 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
327 4 0 6 2.6 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC=C(C=C5)F
CHEMBL471214 acm2_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
495 11 4 6 3.1 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4CC4
CHEMBL486982 acm2_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 5 7 4.0 CCCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL521244 acm2_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
556 11 4 7 3.6 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=CC(=C4)C#N
CHEMBL471214 acm2_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
495 11 4 6 3.1 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4CC4
CHEMBL486982 acm2_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 5 7 4.0 CCCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL521244 acm2_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
556 11 4 7 3.6 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=CC(=C4)C#N
CHEMBL300660 acm2_rat Rat No 7.0 IC50 = 100 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
436 7 1 5 2.5 CCCCN(C)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL49721 acm2_rat Rat No 7.0 IC50 = 100 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
456 6 1 5 2.6 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=C(C=C3)Cl)C(=O)NC4=C2N=CC=C4
CHEMBL17460 acm2_rat Rat No 7.0 IC50 = 100 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
324 4 1 4 0.5 CN(C)CCCC(=O)N1C2=CC=CC=C2C(=O)NC3=C1N=CC=C3
CHEMBL276771 acm2_rat Rat No 7.0 IC50 = 100 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
350 2 1 4 1.6 CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=CC=CC=C42
CHEMBL300660 acm2_rat Rat No 7.0 IC50 = 100 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
436 7 1 5 2.5 CCCCN(C)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL49721 acm2_rat Rat No 7.0 IC50 = 100 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
456 6 1 5 2.6 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=C(C=C3)Cl)C(=O)NC4=C2N=CC=C4
CHEMBL222449 acm2_human Human No 6.0 IC50 = 1000 Funct
Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia
495 6 1 5 4.3 C[N+]1(CCC(C1)N2CC(NC2=O)(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)CC(=O)C5=CC(=CC=C5)F
CHEMBL222449 acm2_human Human No 6.0 IC50 = 1000 Funct
Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia
495 6 1 5 4.3 C[N+]1(CCC(C1)N2CC(NC2=O)(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)CC(=O)C5=CC(=CC=C5)F
CHEMBL103785 acm2_rat Rat No 6.0 IC50 = 1000 Funct
Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.
420 4 2 5 1.5 C1CCN2CCCC(C2C1)CNCC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL29835 acm2_rat Rat Yes 6.0 IC50 = 1000 Funct
Inhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellumInhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellum
251 4 0 2 3.9 CCCN(C1=CC=NC=C1)N2C=CC3=CC=CC=C32
CHEMBL498556 acm2_human Human No 5.0 IC50 = 10000 Funct
Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor
455 4 0 2 4.9 CC(=O)N1CCCC(C1)(C2CCN(CC2)CC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL498556 acm2_human Human No 5.0 IC50 = 10000 Funct
Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor
455 4 0 2 4.9 CC(=O)N1CCCC(C1)(C2CCN(CC2)CC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL279105 acm2_human Human No 4.0 IC50 = 100000 Funct
Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2
241 2 0 5 1.4 CC1=C(CN(CC1)C)C2=NSN=C2SC
CHEMBL3401645 acm2_human Human No 7.0 IC50 = 101.1 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
334 2 2 3 2.4 C1CN2CCC1C(C2)NC(=O)C3(C4=CC=CC=C4C5=CC=CC=C53)O
CHEMBL3401645 acm2_human Human No 7.0 IC50 = 101.1 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
334 2 2 3 2.4 C1CN2CCC1C(C2)NC(=O)C3(C4=CC=CC=C4C5=CC=CC=C53)O
CHEMBL2206599 acm2_human Human No 7.0 IC50 = 104.7 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
622 11 3 5 5.5 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CCCC(C3)[N+](C)(C)CC4=CC=C(C=C4)Cl
CHEMBL315676 acm2_human Human No 6.0 IC50 = 1040 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
164 2 0 3 0.7 C#CCON=C1CN2CCC1C2
CHEMBL1200604 acm2_human Human Yes 7.0 IC50 = 105 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 6 1 3 1.5 CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
CHEMBL1200604 acm2_human Human Yes 7.0 IC50 = 105 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 6 1 3 1.5 CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
CHEMBL657 acm2_human Human Yes 6.0 IC50 = 1050 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
255 6 0 2 3.3 CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2
CHEMBL657 acm2_human Human Yes 6.0 IC50 = 1050 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
255 6 0 2 3.3 CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2
CHEMBL479 acm2_human Human Yes 7.0 IC50 = 106 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
371 4 0 4 5.9 CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL1172 acm2_human Human Yes 7.0 IC50 = 107 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
311 0 1 2 4.5 C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
CHEMBL2206607 acm2_human Human No 7.0 IC50 = 108.3 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
608 13 4 5 5.2 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCC[N+]3(CCCC3)CC4=CC=C(C=C4)Cl
CHEMBL87485 acm2_human Human No 5.0 IC50 = 10800 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
166 3 0 3 1.2 C=CCON=C1CN2CCC1C2
CHEMBL564 acm2_human Human Yes 6.0 IC50 = 1089 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 4 0 3 4.5 CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
CHEMBL2315680 acm2_rat Rat No 6.0 IC50 = 1100 Funct
Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response
428 5 1 8 2.5 CCOC(=O)N1CCC(CC1)N2CCCC(C2)NC(=O)C3=CN=C(C=C3)C(F)(F)F
CHEMBL7303 acm2_rat Rat Yes 5.0 IC50 = 11000 Funct
Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL1779043 acm2_human Human No 6.9 IC50 = 115.7 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
354 5 0 4 3.9 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=C(C=C4)F
CHEMBL1779043 acm2_human Human No 6.9 IC50 = 115.7 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
354 5 0 4 3.9 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=C(C=C4)F
CHEMBL294726 acm2_human Human No 5.9 IC50 = 1151.5 Funct
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
320 1 1 3 3.7 CC1=CC2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC
CHEMBL648 acm2_human Human Yes 5.9 IC50 = 1158 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
266 3 0 2 3.6 CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL648 acm2_human Human Yes 5.9 IC50 = 1158 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
266 3 0 2 3.6 CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL3085084 acm2_human Human No 5.9 IC50 = 1170.8 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
380 6 0 4 4.4 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC(=CC=C3)OC)C4=CC=CC=C4
CHEMBL3085084 acm2_human Human No 5.9 IC50 = 1170.8 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
380 6 0 4 4.4 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC(=CC=C3)OC)C4=CC=CC=C4
CHEMBL333940 acm2_human Human No 5.9 IC50 = 1174.8 Funct
Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells
372 13 0 3 6.6 CCCCCCCCCCOC(=O)C1CN(CC=C1C2=CC=CC=C2)CC
CHEMBL3084639 acm2_human Human No 5.9 IC50 = 1195 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
382 5 0 1 7.3 CN1C2CCC1CC(C2)CC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL3084639 acm2_human Human No 5.9 IC50 = 1195 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
382 5 0 1 7.3 CN1C2CCC1CC(C2)CC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1289758 acm2_human Human No 7.9 IC50 = 12.6 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
420 4 0 5 3.7 CCC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL1289758 acm2_human Human No 7.9 IC50 = 12.6 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
420 4 0 5 3.7 CCC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL416723 acm2_rat Rat No 6.9 IC50 = 120 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
350 2 1 4 0.9 CN1CCCC(C1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL49525 acm2_rat Rat No 6.9 IC50 = 120 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
408 5 1 5 1.6 CCN(C)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL416723 acm2_rat Rat No 6.9 IC50 = 120 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
350 2 1 4 0.9 CN1CCCC(C1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL64000 acm2_rat Rat No 6.9 IC50 = 120 Funct
Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP
169 2 1 3 0.9 CC(=O)OC1CC2CCCC1N2
CHEMBL49525 acm2_rat Rat No 6.9 IC50 = 120 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
408 5 1 5 1.6 CCN(C)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL64000 acm2_human Human No 6.9 IC50 = 120 Funct
Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP
169 2 1 3 0.9 CC(=O)OC1CC2CCCC1N2
CHEMBL9967 acm2_rat Rat Yes 5.9 IC50 = 1200 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
351 2 1 5 0.1 CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL276282 acm2_rat Rat No 5.9 IC50 = 1200 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
351 1 2 4 0.6 CN1CCC(CC1)NC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL2112432 acm2_rat Rat No 4.9 IC50 = 12000 Funct
Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.
402 2 0 4 3.1 C1CCN2CCCC(C2C1)CN3CC4=NC5=C(N4C6=CC=CC=C6C3=O)N=CC=C5
CHEMBL195437 acm2_human Human Yes 4.9 IC50 = 12466 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
206 7 1 1 5.3 CCCCCCCCC1=CC=C(C=C1)O
CHEMBL195437 acm2_human Human Yes 4.9 IC50 = 12466 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
206 7 1 1 5.3 CCCCCCCCC1=CC=C(C=C1)O
CHEMBL526009 acm2_human Human No 6.9 IC50 = 125.9 Funct
Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL526009 acm2_human Human No 6.9 IC50 = 125.9 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL480877 acm2_human Human No 6.9 IC50 = 125.9 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
565 11 4 6 4.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)Cl
CHEMBL1290635 acm2_human Human No 6.9 IC50 = 125.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
385 3 0 3 3.5 C1CN(CCC12CN(CCO2)C(=O)C3=CC=CC=C3)CC4=CC=C(C=C4)Cl
CHEMBL1289201 acm2_human Human No 6.9 IC50 = 125.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
405 4 1 5 2.1 C1CN(CCC12CN(CCO2)C(=O)C3=CC=C(O3)CO)CC4=CC=C(C=C4)Cl
CHEMBL1289315 acm2_human Human No 6.9 IC50 = 125.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
387 3 0 5 2.2 C1CN(CCC12CN(CCO2)C(=O)C3=NC=CC=N3)CC4=CC=C(C=C4)Cl
CHEMBL526009 acm2_human Human No 6.9 IC50 = 125.9 Funct
Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL526009 acm2_human Human No 6.9 IC50 = 125.9 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL480877 acm2_human Human No 6.9 IC50 = 125.9 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
565 11 4 6 4.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)Cl
CHEMBL1290635 acm2_human Human No 6.9 IC50 = 125.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
385 3 0 3 3.5 C1CN(CCC12CN(CCO2)C(=O)C3=CC=CC=C3)CC4=CC=C(C=C4)Cl
CHEMBL1289201 acm2_human Human No 6.9 IC50 = 125.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
405 4 1 5 2.1 C1CN(CCC12CN(CCO2)C(=O)C3=CC=C(O3)CO)CC4=CC=C(C=C4)Cl
CHEMBL1289315 acm2_human Human No 6.9 IC50 = 125.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
387 3 0 5 2.2 C1CN(CCC12CN(CCO2)C(=O)C3=NC=CC=N3)CC4=CC=C(C=C4)Cl
CHEMBL457302 acm2_human Human No 5.9 IC50 = 1258.9 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
575 12 5 7 4.5 CC(C)COC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL1083618 acm2_human Human No 5.9 IC50 = 1258.9 Funct
Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells
345 4 2 3 3.2 C1CNCC=C1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL457302 acm2_human Human No 5.9 IC50 = 1258.9 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
575 12 5 7 4.5 CC(C)COC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL1083618 acm2_human Human No 5.9 IC50 = 1258.9 Funct
Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells
345 4 2 3 3.2 C1CNCC=C1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL2307674 acm2_human Human No 5.9 IC50 = 1273 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
468 8 2 2 6.0 CN1C2CCC1CC(C2)CC(CNC(=O)NCC3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2307674 acm2_human Human No 5.9 IC50 = 1273 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
468 8 2 2 6.0 CN1C2CCC1CC(C2)CC(CNC(=O)NCC3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1306 acm2_human Human Yes 4.9 IC50 = 12909 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
532 8 0 7 4.8 CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL1306 acm2_human Human Yes 4.9 IC50 = 12909 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
532 8 0 7 4.8 CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL2206606 acm2_human Human No 7.9 IC50 = 13.1 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
592 12 4 5 5.3 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCC[N+](C)(C)C34CC5CC(C3)CC(C5)C4
CHEMBL1779037 acm2_human Human No 7.9 IC50 = 13.6 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
316 7 0 3 4.1 CCCCCN(C1=CC=CC=C1)C(=O)OC2CN3CCC2CC3
CHEMBL1779037 acm2_human Human No 7.9 IC50 = 13.6 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
316 7 0 3 4.1 CCCCCN(C1=CC=CC=C1)C(=O)OC2CN3CCC2CC3
CHEMBL59939 acm2_human Human No 4.9 IC50 = 13138 Funct
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
378 3 1 5 3.5 CC1=C(C2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC)C(=O)OC
CHEMBL3085083 acm2_human Human No 5.9 IC50 = 1348.8 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
375 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=C(C=C3)C#N)C4=CC=CC=C4
CHEMBL3085083 acm2_human Human No 5.9 IC50 = 1348.8 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
375 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=C(C=C3)C#N)C4=CC=CC=C4
CHEMBL1180285 acm2_human Human No 6.9 IC50 = 136 Funct
Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay
349 7 0 3 4.4 CCN1CCC(=C(C1)C(=O)OCCC2=CC=C(C=C2)C)C3=CC=CC=C3
CHEMBL3085080 acm2_human Human No 5.9 IC50 = 1364.1 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
380 6 0 4 4.4 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=C(C=C3)OC)C4=CC=CC=C4
CHEMBL3085080 acm2_human Human No 5.9 IC50 = 1364.1 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
380 6 0 4 4.4 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=C(C=C3)OC)C4=CC=CC=C4
CHEMBL1779038 acm2_human Human No 5.9 IC50 = 1364.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
288 4 0 3 3.1 CC(C)N(C1=CC=CC=C1)C(=O)OC2CN3CCC2CC3
CHEMBL1779038 acm2_human Human No 5.9 IC50 = 1364.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
288 4 0 3 3.1 CC(C)N(C1=CC=CC=C1)C(=O)OC2CN3CCC2CC3
CHEMBL8510 acm2_rat Rat Yes 5.9 IC50 = 1380 Funct
Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM
182 2 0 3 -0.4 CN(C)CC#CCN1C(=O)CCO1
CHEMBL291351 acm2_rat Rat No 7.9 IC50 = 14 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
311 4 0 5 2.8 CN1CCC=C(C1)C2=NSN=C2OCC#CC3=CC=CC=C3
CHEMBL223668 acm2_human Human No 6.9 IC50 = 140 Funct
Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia
463 6 1 3 4.7 C[N+]1(CCC(C1)N2CC(NC2=O)(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)CCC5=CC=CC=C5
CHEMBL223668 acm2_human Human No 6.9 IC50 = 140 Funct
Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia
463 6 1 3 4.7 C[N+]1(CCC(C1)N2CC(NC2=O)(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)CCC5=CC=CC=C5
CHEMBL296988 acm2_rat Rat No 6.9 IC50 = 140 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
393 4 1 5 1.2 CN(C)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL17045 acm2_rat Rat Yes 6.9 IC50 = 140 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
422 6 1 5 2.0 CCN(CC)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL296988 acm2_rat Rat No 6.9 IC50 = 140 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
393 4 1 5 1.2 CN(C)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL13308 acm2_mouse Mouse No 5.9 IC50 = 1400 Funct
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex
369 11 0 6 2.5 CN(C)CC1=CC=C(O1)CSCCSCC2=CC=C(O2)CN(C)C
CHEMBL3085082 acm2_human Human No 5.9 IC50 = 1404.7 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
429 5 0 3 5.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3Br)C4=CC=CC=C4
CHEMBL3085082 acm2_human Human No 5.9 IC50 = 1404.7 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
429 5 0 3 5.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3Br)C4=CC=CC=C4
CHEMBL296419 acm2_human Human Yes 5.9 IC50 = 1409 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
459 8 1 5 6.0 COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
CHEMBL60331 acm2_rat Rat No 6.9 IC50 = 142 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
378 4 0 6 3.8 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC(=CC(=C5)Cl)F
CHEMBL3085079 acm2_human Human No 5.9 IC50 = 1423.4 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
429 5 0 3 5.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL3085079 acm2_human Human No 5.9 IC50 = 1423.4 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
429 5 0 3 5.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL55 acm2_human Human Yes 5.9 IC50 = 1425 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
340 10 4 4 2.6 C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N
CHEMBL55 acm2_human Human Yes 5.9 IC50 = 1425 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
340 10 4 4 2.6 C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N
CHEMBL104 acm2_human Human Yes 4.8 IC50 = 14531 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
345 4 0 1 5.0 C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
CHEMBL59347 acm2_human Human No 4.8 IC50 = 14677.7 Funct
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
350 2 1 4 3.6 CC1=CC2=C(N1)C=CC3=C2CN4CCC5=CC(=C(C=C5C4O3)OC)OC
CHEMBL2206605 acm2_human Human No 7.8 IC50 = 15 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
724 15 4 5 8.1 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCC[N+](C)(CC3=CC4=CC=CC=C4C=C3)CC5=CC6=CC=CC=C6C=C5
CHEMBL1290410 acm2_human Human No 7.8 IC50 = 15.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
355 3 0 3 3.7 C1CN(CCC12CCN(CC2)C(=O)C3=CSC=C3)CC4=CC=CC=C4
CHEMBL1289866 acm2_human Human No 7.8 IC50 = 15.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
400 4 0 5 3.4 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=CC=C4
CHEMBL1290410 acm2_human Human No 7.8 IC50 = 15.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
355 3 0 3 3.7 C1CN(CCC12CCN(CC2)C(=O)C3=CSC=C3)CC4=CC=CC=C4
CHEMBL1289866 acm2_human Human No 7.8 IC50 = 15.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
400 4 0 5 3.4 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=CC=C4
CHEMBL299344 acm2_rat Rat Yes 6.8 IC50 = 150 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
500 6 1 5 2.7 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=C(C=C3)Br)C(=O)NC4=C2N=CC=C4
CHEMBL48980 acm2_rat Rat No 6.8 IC50 = 150 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
408 6 1 5 1.6 CCN(CC)CC1CCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL279528 acm2_rat Rat No 6.8 IC50 = 150 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
364 2 1 4 1.3 CN1CCCC(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL81878 acm2_rat Rat No 6.8 IC50 = 150 Funct
In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M
270 4 0 4 2.4 COC1=CC=CC(=C1)C#CCON=C2CN3CCC2C3
CHEMBL299344 acm2_rat Rat Yes 6.8 IC50 = 150 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
500 6 1 5 2.7 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=C(C=C3)Br)C(=O)NC4=C2N=CC=C4
CHEMBL48980 acm2_rat Rat No 6.8 IC50 = 150 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
408 6 1 5 1.6 CCN(CC)CC1CCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL46390 acm2_rat Rat No 5.8 IC50 = 1500 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
450 8 1 5 3.0 CCCN(CCC)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL275537 acm2_mouse Mouse No 5.8 IC50 = 1500 Funct
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex
383 12 0 6 2.8 CN(C)CC1=CC=C(O1)CSCCCSCC2=CC=C(O2)CN(C)C
CHEMBL46390 acm2_rat Rat No 5.8 IC50 = 1500 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
450 8 1 5 3.0 CCCN(CCC)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL85645 acm2_human Human No 4.8 IC50 = 15200 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
246 3 0 4 2.1 C1CN2CC1C(=NOCC#CC3=CSC=C3)C2
CHEMBL3084663 acm2_human Human No 5.8 IC50 = 1553 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
406 7 2 2 4.9 CCNC(=O)NCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3084663 acm2_human Human No 5.8 IC50 = 1553 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
406 7 2 2 4.9 CCNC(=O)NCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL352832 acm2_human Human No 4.8 IC50 = 15590 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
178 3 0 3 1.1 C#CCCON=C1CN2CCC1C2
CHEMBL114484 acm2_human Human No 5.8 IC50 = 1570 Funct
Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2
356 3 1 2 4.5 CC1=CC(=C(C=C1)CN2CCC(CC2)N3C4=CC=CC=C4NC3=O)Cl
CHEMBL505452 acm2_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL505452 acm2_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL519760 acm2_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 4 7 3.8 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=CC=C4OC
CHEMBL518001 acm2_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)O
CHEMBL505452 acm2_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL505452 acm2_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL519760 acm2_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 4 7 3.8 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=CC=C4OC
CHEMBL518001 acm2_human Human No 6.8 IC50 = 158.5 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)O
CHEMBL502000 acm2_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL451040 acm2_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
569 10 5 6 3.4 CC(C)NC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)C#N
CHEMBL448904 acm2_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
581 11 5 6 3.4 C1CC1CNC(=O)C2=CC=C(C=C2)NC(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC4CCN(C4)CC5=CC=C(C=C5)C#N
CHEMBL502000 acm2_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL451040 acm2_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
569 10 5 6 3.4 CC(C)NC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)C#N
CHEMBL448904 acm2_human Human No 5.8 IC50 = 1584.9 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
581 11 5 6 3.4 C1CC1CNC(=O)C2=CC=C(C=C2)NC(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC4CCN(C4)CC5=CC=C(C=C5)C#N
CHEMBL169011 acm2_human Human No 4.8 IC50 = 15900 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
204 3 0 3 1.9 C=CCC#CCON=C1CN2CCC1C2
CHEMBL60419 acm2_rat Rat No 7.8 IC50 = 16 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
309 4 0 5 2.5 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC=CC=C5
CHEMBL12781 acm2_mouse Mouse No 5.8 IC50 = 1600 Funct
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex
521 13 0 6 5.4 CN(C)CC1=CC=C(O1)CSCC2=CC=C(C=C2)C3=CC=C(C=C3)CSCC4=CC=C(O4)CN(C)C
CHEMBL27384 acm2_rat Rat Yes 4.8 IC50 = 16000 Funct
Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart
168 1 0 4 0.4 CN1CCC2=C(C1)C(=NO2)OC
CHEMBL120135 acm2_human Human No 5.8 IC50 = 1611.2 Funct
Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells
315 5 0 3 4.2 CCN1CCC(C(C1)C(=O)OC2CCCCC2)C3=CC=CC=C3
CHEMBL354259 acm2_human Human No 5.8 IC50 = 1630 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
180 2 0 3 1.5 C1CC(C1)ON=C2CN3CCC2C3
CHEMBL61700 acm2_human Human No 5.8 IC50 = 1646 Funct
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
455 5 1 5 5.4 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC6=CC=CC=C6)C
CHEMBL1411979 acm2_human Human Yes 5.8 IC50 = 1665 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
261 6 0 4 2.6 CN(C)CCN(CC1=CC=CS1)C2=CC=CC=N2
CHEMBL85678 acm2_human Human No 4.8 IC50 = 16800 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
140 1 0 3 0.6 CON=C1CN2CCC1C2
CHEMBL59862 acm2_rat Rat No 5.8 IC50 = 1688 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
377 4 0 4 5.4 C1C2CC3C1C3(C2)C4=NSN=C4OCC#CC5=CC(=CC(=C5)Cl)Cl
CHEMBL64000 acm2_rat Rat No 7.8 IC50 = 17 Funct
Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP
169 2 1 3 0.9 CC(=O)OC1CC2CCCC1N2
CHEMBL64000 acm2_human Human No 7.8 IC50 = 17 Funct
Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP
169 2 1 3 0.9 CC(=O)OC1CC2CCCC1N2
CHEMBL295214 acm2_rat Rat No 6.8 IC50 = 170 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
422 6 1 5 1.8 CCN(CC)CC1CCCN(C1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL295214 acm2_rat Rat No 6.8 IC50 = 170 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
422 6 1 5 1.8 CCN(CC)CC1CCCN(C1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL354738 acm2_human Human No 5.8 IC50 = 1700 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
178 2 0 3 1.2 CC#CCON=C1CN2CCC1C2
CHEMBL1180284 acm2_human Human No 5.8 IC50 = 1728 Funct
Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay
245 4 0 3 2.1 CCN1CCC(=C(C1)C(=O)OC)C2=CC=CC=C2
CHEMBL274329 acm2_rat Rat No 4.8 IC50 = 17400 Funct
Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM
197 2 0 2 -0.4 C[N+](C)(C)CC#CCN1C(=O)CCO1
CHEMBL2206585 acm2_human Human No 6.8 IC50 = 178.5 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
596 14 4 5 5.1 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCCC[N+](C)(C)CC3=CC=C(C=C3)Cl
CHEMBL499519 acm2_human Human No 5.8 IC50 = 1780 Funct
Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells
758 23 5 11 6.2 CCCCCCCCCCCC(C(C)C(=O)NC1CCCCN(C1=O)O)OC(=O)C(CCCCN(C(=O)C)O)NC(=O)C2=COC(=C3C=CC=CC3=O)N2
CHEMBL134641 acm2_human Human Yes 6.8 IC50 = 180 Funct
In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2
193 2 0 4 1.0 CON=C(C#N)C1CN2CCC1CC2
CHEMBL7303 acm2_human Human Yes 5.8 IC50 = 1800 Funct
In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL341447 acm2_human Human No 4.8 IC50 = 18000 Funct
In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2
267 4 0 2 2.5 C[N+](C)(C)CC#CCOC(=O)C1=CC(=CC=C1)Cl
CHEMBL2206595 acm2_human Human No 6.7 IC50 = 181.2 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
716 14 4 5 6.8 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCC3=[N+](C=CN3CC4=CC=C(C=C4)Cl)CC5=CC=C(C=C5)Cl
CHEMBL166736 acm2_rat Rat No 4.7 IC50 = 18900 Funct
Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates
153 3 0 2 0.4 CC(=O)CCC#CCN(C)C
CHEMBL3085091 acm2_human Human No 7.7 IC50 = 19.6 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
363 5 0 5 3.8 CN1C2CCC1CC(C2)OC(=O)N(CC3=CSC=C3)C4=CSC=C4
CHEMBL3085091 acm2_human Human No 7.7 IC50 = 19.6 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
363 5 0 5 3.8 CN1C2CCC1CC(C2)OC(=O)N(CC3=CSC=C3)C4=CSC=C4
CHEMBL1289082 acm2_human Human No 7.7 IC50 = 20.0 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
391 3 0 4 3.6 C1CN(CCC12CN(CCO2)C(=O)C3=CC=CS3)CC4=CC=C(C=C4)Cl
CHEMBL1289082 acm2_human Human No 7.7 IC50 = 20.0 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
391 3 0 4 3.6 C1CN(CCC12CN(CCO2)C(=O)C3=CC=CS3)CC4=CC=C(C=C4)Cl
CHEMBL3085086 acm2_human Human No 6.7 IC50 = 190.5 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
371 5 0 4 4.5 CC1=C(SC=C1)CN(C2=CC=CC=C2)C(=O)OC3CC4CCC(C3)N4C
CHEMBL3085086 acm2_human Human No 6.7 IC50 = 190.5 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
371 5 0 4 4.5 CC1=C(SC=C1)CN(C2=CC=CC=C2)C(=O)OC3CC4CCC(C3)N4C
CHEMBL86903 acm2_human Human No 5.7 IC50 = 1900 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
204 4 0 3 1.9 CC(=CCON=C1CN2CCC1C2)C#C
CHEMBL2111621 acm2_rat Rat No 5.7 IC50 = 1900 Funct
Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.
390 2 1 4 1.8 C1CCN2CCCC(C2C1)CC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL61412 acm2_human Human No 5.7 IC50 = 1905.1 Funct
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
406 5 1 5 4.4 CCCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC)C
CHEMBL2206588 acm2_human Human No 6.7 IC50 = 191 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
566 10 3 5 4.9 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CC[N+](CC3)(C)CC4CCCCC4
CHEMBL21731 acm2_human Human Yes 5.7 IC50 = 1927 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
277 4 1 1 4.6 CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24
CHEMBL21731 acm2_human Human Yes 5.7 IC50 = 1927 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
277 4 1 1 4.6 CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24
CHEMBL1779042 acm2_human Human No 6.7 IC50 = 195.6 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
350 5 0 3 4.2 CC1=CC=C(C=C1)N(CC2=CC=CC=C2)C(=O)OC3CN4CCC3CC4
CHEMBL1779042 acm2_human Human No 6.7 IC50 = 195.6 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
350 5 0 3 4.2 CC1=CC=C(C=C1)N(CC2=CC=CC=C2)C(=O)OC3CN4CCC3CC4
CHEMBL480878 acm2_human Human No 6.7 IC50 = 199.5 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
531 11 4 6 3.9 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=CC=C4
CHEMBL501419 acm2_human Human No 6.7 IC50 = 199.5 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
575 11 4 8 3.7 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC5=C(C=C4)OCO5
CHEMBL1083925 acm2_human Human No 6.7 IC50 = 199.5 Funct
Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells
361 4 2 3 4.3 CC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL480878 acm2_human Human No 6.7 IC50 = 199.5 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
531 11 4 6 3.9 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=CC=C4
CHEMBL501419 acm2_human Human No 6.7 IC50 = 199.5 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
575 11 4 8 3.7 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC5=C(C=C4)OCO5
CHEMBL1083925 acm2_human Human No 6.7 IC50 = 199.5 Funct
Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells
361 4 2 3 4.3 CC1CNCCC1CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl
CHEMBL1083108 acm2_human Human No 5.7 IC50 = 1995.3 Funct
Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=C(C=CC(=C3)Cl)F
CHEMBL1083108 acm2_human Human No 5.7 IC50 = 1995.3 Funct
Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells
347 4 2 3 3.9 C1CNCCC1CNC(=O)C2=CC=CC=C2C3=C(C=CC(=C3)Cl)F
CHEMBL501727 acm2_human Human No 4.7 IC50 = 19952.6 Funct
Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL501727 acm2_human Human No 4.7 IC50 = 19952.6 Funct
Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL1290184 acm2_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
363 3 0 2 4.4 CC1=CC(=CC=C1)CN2CCC3(CC2)CCN(CC3)C(=O)C4=CC=CC=C4
CHEMBL1290184 acm2_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
363 3 0 2 4.4 CC1=CC(=CC=C1)CN2CCC3(CC2)CCN(CC3)C(=O)C4=CC=CC=C4
CHEMBL549577 acm2_human Human No 8.6 IC50 = 2.8 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
335 3 0 4 3.2 C1CN2CCC1C(C2)OC(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL549577 acm2_human Human No 8.6 IC50 = 2.8 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting
335 3 0 4 3.2 C1CN2CCC1C(C2)OC(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL418491 acm2_rat Rat No 7.7 IC50 = 20 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
343 4 0 6 3.2 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC=C(C=C5)F
CHEMBL314737 acm2_human Human Yes 7.7 IC50 = 20 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
180 1 1 5 0.1 C1CN2CC1C(C2)C3=NC(=NO3)N
CHEMBL332320 acm2_human Human No 7.7 IC50 = 20.5 Funct
Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells
372 13 0 3 6.6 CCCCCCCCCCOC(=O)C1=C(CCN(C1)CC)C2=CC=CC=C2
CHEMBL50176 acm2_rat Rat No 6.7 IC50 = 200 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
450 7 1 5 2.8 CCC1=CC2=C(C=C1)N(C3=C(C=CC=N3)NC2=O)C(=O)CN4CCCCC4CN(CC)CC
CHEMBL17228 acm2_rat Rat No 6.7 IC50 = 200 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
310 3 1 4 0.2 CN(C)CCC(=O)N1C2=CC=CC=C2C(=O)NC3=C1N=CC=C3
CHEMBL50176 acm2_rat Rat No 6.7 IC50 = 200 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
450 7 1 5 2.8 CCC1=CC2=C(C=C1)N(C3=C(C=CC=N3)NC2=O)C(=O)CN4CCCCC4CN(CC)CC
CHEMBL496376 acm2_human Human No 5.7 IC50 = 2000 Funct
Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor
470 6 1 3 4.4 C1CC(CN(C1)CC(=O)N)(C2CCN(CC2)CC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL496376 acm2_human Human No 5.7 IC50 = 2000 Funct
Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor
470 6 1 3 4.4 C1CC(CN(C1)CC(=O)N)(C2CCN(CC2)CC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL44838 acm2_rat Rat No 5.7 IC50 = 2000 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
436 6 1 5 2.3 CCN(CC)CC1CCCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL44838 acm2_rat Rat No 5.7 IC50 = 2000 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
436 6 1 5 2.3 CCN(CC)CC1CCCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL11081 acm2_rat Rat Yes 5.7 IC50 = 2010 Funct
Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates
194 2 0 2 0.3 CC(=O)N(C)CC#CCN1CCCC1
CHEMBL81895 acm2_human Human No 4.7 IC50 = 20600 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
275 3 0 3 3.1 C1CN2CC1C(=NOCC#CC3=CC(=CC=C3)Cl)C2
CHEMBL166782 acm2_human Human No 4.7 IC50 = 20600 Funct
Compound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsCompound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
206 3 0 3 2.2 CCCC#CCON=C1CN2CCC1C2
CHEMBL313749 acm2_human Human No 4.7 IC50 = 20800 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
258 3 0 4 2.6 C1CN2CC1C(=NOCC#CC3=CC=CC=C3F)C2
CHEMBL304247 acm2_rat Rat No 7.7 IC50 = 21 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
327 4 0 6 2.6 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC(=CC=C5)F
CHEMBL95 acm2_rat Rat Yes 5.7 IC50 = 2100 Funct
Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine
198 0 1 2 2.7 C1CCC2=NC3=CC=CC=C3C(=C2C1)N
CHEMBL95 acm2_mouse Mouse Yes 5.7 IC50 = 2100 Funct
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex
198 0 1 2 2.7 C1CCC2=NC3=CC=CC=C3C(=C2C1)N
CHEMBL7002 acm2_human Human Yes 4.7 IC50 = 21107 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
333 5 1 4 4.8 CC1(CCCCC1)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL7002 acm2_human Human Yes 4.7 IC50 = 21107 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
333 5 1 4 4.8 CC1(CCCCC1)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
CHEMBL3084670 acm2_human Human No 5.7 IC50 = 2119 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
413 7 1 4 4.5 CN1C2CCC1CC(C2)CC(CNS(=O)(=O)C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3084670 acm2_human Human No 5.7 IC50 = 2119 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
413 7 1 4 4.5 CN1C2CCC1CC(C2)CC(CNS(=O)(=O)C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL275104 acm2_rat Rat No 6.7 IC50 = 215 Funct
Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM
208 2 0 3 0.1 C1CCN(C1)CC#CCN2C(=O)CCO2
CHEMBL3085081 acm2_human Human No 5.7 IC50 = 2157.2 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
429 5 0 3 5.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC(=CC=C3)Br)C4=CC=CC=C4
CHEMBL3085081 acm2_human Human No 5.7 IC50 = 2157.2 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
429 5 0 3 5.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC(=CC=C3)Br)C4=CC=CC=C4
CHEMBL83074 acm2_human Human No 5.7 IC50 = 2180 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
240 2 0 3 2.1 C#CCC#CCC#CCON=C1CN2CCC1C2
CHEMBL83074 acm2_human Human No 5.7 IC50 = 2180 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
240 2 0 3 2.1 C#CCC#CCC#CCON=C1CN2CCC1C2
CHEMBL58 acm2_human Human Yes 6.7 IC50 = 219 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
444 12 8 10 1.0 C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO
CHEMBL58 acm2_human Human Yes 6.7 IC50 = 219 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
444 12 8 10 1.0 C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO
CHEMBL121059 acm2_human Human No 7.7 IC50 = 22.2 Funct
Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells
358 12 0 3 6.0 CCCCCCCCCOC(=O)C1=C(CCN(C1)CC)C2=CC=CC=C2
CHEMBL1779040 acm2_human Human No 7.6 IC50 = 22.7 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
363 6 0 5 3.2 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CS3)CC4=CC=CS4
CHEMBL1779040 acm2_human Human No 7.6 IC50 = 22.7 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
363 6 0 5 3.2 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CS3)CC4=CC=CS4
CHEMBL1779036 acm2_human Human No 7.6 IC50 = 22.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
302 6 0 3 3.6 CCCCN(C1=CC=CC=C1)C(=O)OC2CN3CCC2CC3
CHEMBL1779036 acm2_human Human No 7.6 IC50 = 22.9 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
302 6 0 3 3.6 CCCCN(C1=CC=CC=C1)C(=O)OC2CN3CCC2CC3
CHEMBL296317 acm2_rat Rat No 6.7 IC50 = 220 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
436 7 1 5 1.9 CCN(CC)CC1CCCCN1CCC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL132698 acm2_human Human No 6.7 IC50 = 220 Funct
In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2
154 2 0 3 0.5 CON=CC1CN2CCC1C2
CHEMBL296317 acm2_rat Rat No 6.7 IC50 = 220 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
436 7 1 5 1.9 CCN(CC)CC1CCCCN1CCC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL15675 acm2_human Human No 5.7 IC50 = 2200 Funct
Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2
225 0 0 5 0.6 CN1CCC2=C(C1)C3=NSN=C3SC2
CHEMBL12937 acm2_mouse Mouse No 5.7 IC50 = 2200 Funct
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex
397 13 0 6 3.2 CN(C)CC1=CC=C(O1)CSCCCCSCC2=CC=C(O2)CN(C)C
CHEMBL3401642 acm2_human Human No 6.6 IC50 = 229.6 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
332 4 1 4 2.9 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CS3)C4=CC=CS4
CHEMBL3401642 acm2_human Human No 6.6 IC50 = 229.6 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
332 4 1 4 2.9 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CS3)C4=CC=CS4
CHEMBL8610 acm2_rat Rat No 6.6 IC50 = 233 Funct
Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM
208 3 0 4 0.8 C1CCN(C1)CC#CCOC2=NOCC2
CHEMBL1902981 acm2_human Human Yes 5.6 IC50 = 2338 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
259 5 0 2 3.8 CCC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2
CHEMBL3084678 acm2_human Human No 6.6 IC50 = 240 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
349 5 1 3 2.4 CN1C2CCC1CC(C2)CC(C3=CC=CC=C3)(C4=CC=CC=C4)C(=O)O
CHEMBL3084678 acm2_human Human No 6.6 IC50 = 240 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
349 5 1 3 2.4 CN1C2CCC1CC(C2)CC(C3=CC=CC=C3)(C4=CC=CC=C4)C(=O)O
CHEMBL344892 acm2_human Human No 6.6 IC50 = 240 Funct
In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2
179 2 0 4 0.5 CON=C(C#N)C12CCN(C1)CC2
CHEMBL322378 acm2_rat Rat No 5.6 IC50 = 2400 Funct
Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.
391 5 1 3 4.4 CC1=C(C=CC(=C1)C(=O)C2=CC=CC=C2)NC(=O)CC3CCCN4C3CCCC4
CHEMBL104355 acm2_rat Rat Yes 5.6 IC50 = 2400 Funct
Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue
353 8 1 7 3.5 CN(C)CC1=CC=C(O1)CSCCNC2=C(C=C(C=C2)F)[N+](=O)[O-]
CHEMBL106344 acm2_rat Rat No 5.6 IC50 = 2400 Funct
Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue
487 11 2 10 4.2 CN(C)CC1=CC=C(O1)CSCCNC2=C(C=C(C(=C2)NCC3=CC=CC=N3)[N+](=O)[O-])[N+](=O)[O-]
CHEMBL415 acm2_human Human Yes 6.6 IC50 = 241 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL60374 acm2_rat Rat No 6.6 IC50 = 242 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
360 4 0 5 3.7 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC=C(C=C5)Cl
CHEMBL420781 acm2_human Human No 4.6 IC50 = 24700 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
275 3 0 3 3.1 C1CN2CC1C(=NOCC#CC3=CC=C(C=C3)Cl)C2
CHEMBL1289081 acm2_human Human No 7.6 IC50 = 25.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
375 3 0 4 2.9 C1CN(CCC12CN(CCO2)C(=O)C3=CC=CO3)CC4=CC=C(C=C4)Cl
CHEMBL1289982 acm2_human Human No 7.6 IC50 = 25.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
434 4 0 5 4.1 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=CC=C4Cl
CHEMBL1289081 acm2_human Human No 7.6 IC50 = 25.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
375 3 0 4 2.9 C1CN(CCC12CN(CCO2)C(=O)C3=CC=CO3)CC4=CC=C(C=C4)Cl
CHEMBL1289982 acm2_human Human No 7.6 IC50 = 25.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
434 4 0 5 4.1 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=CC=C4Cl
CHEMBL216928 acm2_human Human No 6.6 IC50 = 251.2 Funct
Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation
488 16 0 13 2.1 CN1CCC=CC1C2=NSN=C2OCCOCCOCCOCCOC3=NC(=NS3)OC
CHEMBL480299 acm2_human Human No 6.6 IC50 = 251.2 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 4 7 3.8 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)OC
CHEMBL1290520 acm2_human Human No 6.6 IC50 = 251.2 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
350 3 0 4 2.6 C1CN(CCC12CCN(CC2)C(=O)C3=NC=CC=N3)CC4=CC=CC=C4
CHEMBL216928 acm2_human Human No 6.6 IC50 = 251.2 Funct
Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation
488 16 0 13 2.1 CN1CCC=CC1C2=NSN=C2OCCOCCOCCOCCOC3=NC(=NS3)OC
CHEMBL480299 acm2_human Human No 6.6 IC50 = 251.2 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 4 7 3.8 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)OC
CHEMBL1290520 acm2_human Human No 6.6 IC50 = 251.2 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
350 3 0 4 2.6 C1CN(CCC12CCN(CC2)C(=O)C3=NC=CC=N3)CC4=CC=CC=C4
CHEMBL513228 acm2_human Human No 5.6 IC50 = 2511.9 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
469 10 4 6 2.7 CCN1CCC(C1)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)NC3=CC=C(C=C3)C(=O)OCC
CHEMBL1082365 acm2_human Human No 5.6 IC50 = 2511.9 Funct
Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells
379 4 2 4 4.3 CC1CNCCC1(CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL513228 acm2_human Human No 5.6 IC50 = 2511.9 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
469 10 4 6 2.7 CCN1CCC(C1)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)NC3=CC=C(C=C3)C(=O)OCC
CHEMBL1082365 acm2_human Human No 5.6 IC50 = 2511.9 Funct
Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells
379 4 2 4 4.3 CC1CNCCC1(CNC(=O)C2=C(C=CC=C2F)C3=CC(=CC=C3)Cl)F
CHEMBL3085076 acm2_human Human No 6.6 IC50 = 253.8 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
350 5 0 3 4.4 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3085076 acm2_human Human No 6.6 IC50 = 253.8 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
350 5 0 3 4.4 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3401644 acm2_human Human No 5.6 IC50 = 2531.4 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
294 4 2 4 1.6 CCC(C1=CC=CS1)(C(=O)NC2CN3CCC2CC3)O
CHEMBL62247 acm2_human Human No 5.6 IC50 = 2565 Funct
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
406 5 1 5 4.2 CCOC1=CC2=C(C=C1)C3N(CC2)CC4=C(O3)C=CC5=C4C(=C(N5)C)C(=O)OCC
CHEMBL84893 acm2_human Human No 4.6 IC50 = 25800 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
240 3 0 3 2.5 C1CN2CC1C(=NOCC#CC3=CC=CC=C3)C2
CHEMBL84893 acm2_human Human No 4.6 IC50 = 25800 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
240 3 0 3 2.5 C1CN2CC1C(=NOCC#CC3=CC=CC=C3)C2
CHEMBL293982 acm2_rat Rat No 7.6 IC50 = 26 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
343 4 0 6 3.2 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC(=CC=C5)F
CHEMBL3085089 acm2_human Human No 7.6 IC50 = 26.5 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.4 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=CS4
CHEMBL3085089 acm2_human Human No 7.6 IC50 = 26.5 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.4 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=CS4
CHEMBL1779044 acm2_human Human No 7.6 IC50 = 26.8 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
372 5 0 5 4.0 C1CN2CCC1C(C2)OC(=O)N(CC3=CC(=CC=C3)F)C4=CC(=CC=C4)F
CHEMBL1779044 acm2_human Human No 7.6 IC50 = 26.8 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
372 5 0 5 4.0 C1CN2CCC1C(C2)OC(=O)N(CC3=CC(=CC=C3)F)C4=CC(=CC=C4)F
CHEMBL1113 acm2_human Human Yes 5.6 IC50 = 2623 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
314 1 1 3 2.6 C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
CHEMBL62251 acm2_human Human No 5.6 IC50 = 2643 Funct
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
406 4 1 5 4.3 CC1=C(C2=C(N1)C=CC3=C2CN4CCC5=C(C4O3)C=CC(=C5)OC)C(=O)OC(C)C
CHEMBL301041 acm2_human Human No 5.6 IC50 = 2680.7 Funct
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
362 3 1 4 3.9 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=CC=CC=C5CCN4C3)C
CHEMBL1231 acm2_human Human Yes 7.6 IC50 = 27 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
357 8 1 4 4.2 CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
CHEMBL1231 acm2_human Human Yes 7.6 IC50 = 27 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
357 8 1 4 4.2 CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
CHEMBL417560 acm2_rat Rat No 7.6 IC50 = 27 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
325 4 0 5 3.1 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC=CC=C5
CHEMBL1090097 acm2_human Human No 5.6 IC50 = 2700 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization
480 4 1 9 5.5 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=C(C=CC(=C3)C(F)(F)F)C(F)(F)F)Cl
CHEMBL1090097 acm2_human Human No 5.6 IC50 = 2700 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization
480 4 1 9 5.5 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=C(C=CC(=C3)C(F)(F)F)C(F)(F)F)Cl
CHEMBL3085092 acm2_human Human No 6.6 IC50 = 271.2 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
363 5 0 4 4.9 CN1C2CCC1CC(C2)OC(=O)N(CC3CCCCC3)C4=CSC=C4
CHEMBL3085092 acm2_human Human No 6.6 IC50 = 271.2 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
363 5 0 4 4.9 CN1C2CCC1CC(C2)OC(=O)N(CC3CCCCC3)C4=CSC=C4
CHEMBL314420 acm2_human Human No 4.6 IC50 = 27200 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
258 3 0 4 2.6 C1CN2CC1C(=NOCC#CC3=CC=C(C=C3)F)C2
CHEMBL809 acm2_human Human Yes 5.6 IC50 = 2767.5 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
306 2 1 1 4.8 CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
CHEMBL809 acm2_human Human Yes 5.6 IC50 = 2767.5 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
306 2 1 1 4.8 CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
CHEMBL1779031 acm2_human Human No 5.6 IC50 = 2779 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
322 4 0 3 3.9 C1CN2CCC1C(C2)OC(=O)N(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1779031 acm2_human Human No 5.6 IC50 = 2779 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
322 4 0 3 3.9 C1CN2CCC1C(C2)OC(=O)N(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL64029 acm2_rat Rat No 7.6 IC50 = 28 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
361 4 0 7 3.3 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC(=CC(=C5)F)F
CHEMBL275104 acm2_rat Rat No 5.6 IC50 = 2800 Funct
Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM
208 2 0 3 0.1 C1CCN(C1)CC#CCN2C(=O)CCO2
CHEMBL313918 acm2_human Human No 5.6 IC50 = 2840 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
202 2 0 3 1.4 C#CCC#CCON=C1CN2CCC1C2
CHEMBL3401647 acm2_human Human No 6.5 IC50 = 285.9 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
348 2 0 3 3.2 CN(C1CN2CCC1CC2)C(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL3401647 acm2_human Human No 6.5 IC50 = 285.9 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
348 2 0 3 3.2 CN(C1CN2CCC1CC2)C(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL271704 acm2_rat Rat No 4.5 IC50 = 29000 Funct
Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay
384 5 1 3 3.9 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3CC3C4=CC=CC=C4)Cl
CHEMBL271704 acm2_rat Rat No 4.5 IC50 = 29000 Funct
Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay
384 5 1 3 3.9 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3CC3C4=CC=CC=C4)Cl
CHEMBL1200623 acm2_human Human Yes 6.5 IC50 = 292 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
288 1 1 1 5.1 CCC1(CCC2C1(CCC3C2CCC4=CCCCC34)C)O
CHEMBL1535 acm2_human Human Yes 5.5 IC50 = 2951 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
336 9 2 4 3.6 CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
CHEMBL1535 acm2_human Human Yes 5.5 IC50 = 2951 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
336 9 2 4 3.6 CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
CHEMBL1289545 acm2_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
406 3 0 5 3.3 CC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL1289654 acm2_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
406 3 0 5 3.3 CC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=CC=C4Cl
CHEMBL1289545 acm2_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
406 3 0 5 3.3 CC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL1289654 acm2_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
406 3 0 5 3.3 CC1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=CC=C4Cl
CHEMBL1777826 acm2_human Human No 8.4 IC50 = 3.7 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
336 5 0 3 3.8 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1777826 acm2_human Human No 8.4 IC50 = 3.7 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
336 5 0 3 3.8 C1CN2CCC1C(C2)OC(=O)N(CC3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1290183 acm2_human Human No 8.4 IC50 = 4.0 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
383 3 0 2 4.6 C1CN(CCC12CCN(CC2)C(=O)C3=CC=CC=C3)CC4=CC(=CC=C4)Cl
CHEMBL1290183 acm2_human Human No 8.4 IC50 = 4.0 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
383 3 0 2 4.6 C1CN(CCC12CCN(CC2)C(=O)C3=CC=CC=C3)CC4=CC(=CC=C4)Cl
CHEMBL297224 acm2_rat Rat No 7.5 IC50 = 30 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
436 6 1 5 2.3 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=C(C=C3)C)C(=O)NC4=C2N=CC=C4
CHEMBL46315 acm2_rat Rat No 7.5 IC50 = 30 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
476 5 1 5 3.6 CN(CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4)C5CCCCCC5
CHEMBL291872 acm2_rat Rat No 7.5 IC50 = 30 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
345 4 0 7 2.7 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC(=CC(=C5)F)F
CHEMBL297224 acm2_rat Rat No 7.5 IC50 = 30 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
436 6 1 5 2.3 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=C(C=C3)C)C(=O)NC4=C2N=CC=C4
CHEMBL46315 acm2_rat Rat No 7.5 IC50 = 30 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
476 5 1 5 3.6 CN(CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4)C5CCCCCC5
CHEMBL318517 acm2_rat Rat No 6.5 IC50 = 300 Funct
Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue
523 13 2 11 3.8 CN(C)CC1=CC=C(O1)CSCCNC2=C(C=C(C(=C2)NCCCN3CCOCC3)[N+](=O)[O-])[N+](=O)[O-]
CHEMBL277078 acm2_rat Rat No 5.5 IC50 = 3000 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
351 2 1 5 0.1 CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3NC(=O)C4=C2N=CC=C4
CHEMBL300987 acm2_human Human No 5.5 IC50 = 3002.9 Funct
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
392 4 1 5 3.9 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=CC(=C5)OC)C
CHEMBL312823 acm2_human Human No 4.5 IC50 = 30200 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
190 3 0 3 1.3 C#CC=CCON=C1CN2CCC1C2
CHEMBL37132 acm2_rat Rat No 4.5 IC50 = 30910 Funct
Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)
209 3 0 3 0.4 CCN1C(COC1=O)CC2=CN=CN2C
CHEMBL135645 acm2_human Human No 7.5 IC50 = 31 Funct
In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2
193 2 0 4 0.9 CON=C(C#N)C12CCCN(C1)CC2
CHEMBL1289865 acm2_human Human No 7.5 IC50 = 31.6 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
434 4 0 5 4.1 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL1290752 acm2_human Human No 7.5 IC50 = 31.6 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
425 3 0 4 3.9 C1CN(CCC12CN(CCO2)C(=O)C3=CC4=C(C=C3)OC=C4)CC5=CC=C(C=C5)Cl
CHEMBL1289865 acm2_human Human No 7.5 IC50 = 31.6 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
434 4 0 5 4.1 CC(C)C1=NC(=CS1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL1290752 acm2_human Human No 7.5 IC50 = 31.6 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
425 3 0 4 3.9 C1CN(CCC12CN(CCO2)C(=O)C3=CC4=C(C=C3)OC=C4)CC5=CC=C(C=C5)Cl
CHEMBL320291 acm2_rat Rat No 5.5 IC50 = 3100 Funct
Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine
409 9 2 9 3.8 CNC1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])NCCSCC2=CC=C(O2)CN(C)C
CHEMBL2206604 acm2_human Human No 6.5 IC50 = 311.2 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
610 15 4 5 5.5 CC[N+](CC)(CCNC(=O)C(CC1=CC=C(C=C1)O)NC(=O)NC2=CC=C(C=C2)C(=O)OC(C)C)CC3=CC=C(C=C3)Cl
CHEMBL728 acm2_human Human Yes 5.5 IC50 = 3112 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL166423 acm2_human Human No 5.5 IC50 = 3150 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
168 2 0 3 1.4 CC(C)ON=C1CN2CCC1C2
CHEMBL244946 acm2_human Human Yes 6.5 IC50 = 316.2 Funct
Antagonist activity at human muscarinic receptor M2Antagonist activity at human muscarinic receptor M2
538 7 0 6 5.4 CC1=NC2=CC=CC(=C2C=C1)C3=NN=C(N3C)SCCCN4CCC5=C(CC4)C=C(C=C5)C6=CC(=NN6C)C
CHEMBL479526 acm2_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
533 10 5 7 3.1 COC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL517087 acm2_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 4 7 3.8 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)OC
CHEMBL244946 acm2_human Human Yes 6.5 IC50 = 316.2 Funct
Antagonist activity at human muscarinic receptor M2Antagonist activity at human muscarinic receptor M2
538 7 0 6 5.4 CC1=NC2=CC=CC(=C2C=C1)C3=NN=C(N3C)SCCCN4CCC5=C(CC4)C=C(C=C5)C6=CC(=NN6C)C
CHEMBL479526 acm2_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
533 10 5 7 3.1 COC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL517087 acm2_human Human No 6.5 IC50 = 316.2 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
561 12 4 7 3.8 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)OC
CHEMBL218755 acm2_human Human No 5.5 IC50 = 3162.3 Funct
Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation
444 13 0 12 1.4 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOC3=NSN=C3OC
CHEMBL218755 acm2_human Human No 5.5 IC50 = 3162.3 Funct
Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation
444 13 0 12 1.4 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOC3=NSN=C3OC
CHEMBL503468 acm2_human Human No 5.5 IC50 = 3200 Funct
Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor
771 14 4 6 8.9 C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CCCCCCCN5CCC(CC5)C6=CNC7=C6C=C(C=C7)NC(=O)C8=CC=C(C=C8)F
CHEMBL503468 acm2_human Human No 5.5 IC50 = 3200 Funct
Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor
771 14 4 6 8.9 C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CCCCCCCN5CCC(CC5)C6=CNC7=C6C=C(C=C7)NC(=O)C8=CC=C(C=C8)F
CHEMBL808 acm2_human Human Yes 5.5 IC50 = 3256 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
382 6 0 2 5.3 C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL808 acm2_human Human Yes 5.5 IC50 = 3256 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
382 6 0 2 5.3 C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL2206609 acm2_human Human No 6.5 IC50 = 327.8 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
526 11 4 5 3.8 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCC[N+]3(CCCCCC3)C
CHEMBL296405 acm2_rat Rat No 6.5 IC50 = 330 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
436 7 1 5 2.3 CCN(CC)CCC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL296405 acm2_rat Rat No 6.5 IC50 = 330 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
436 7 1 5 2.3 CCN(CC)CCC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL106936 acm2_rat Rat No 5.5 IC50 = 3300 Funct
Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue
486 11 2 9 5.3 CN(C)CC1=CC=C(O1)CSCCNC2=C(C=C(C(=C2)NCC3=CC=CC=C3)[N+](=O)[O-])[N+](=O)[O-]
CHEMBL2206610 acm2_human Human No 6.5 IC50 = 336.8 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
528 13 4 5 4.2 CC(C)[N+](C)(CCNC(=O)C(CC1=CC=C(C=C1)O)NC(=O)NC2=CC=C(C=C2)C(=O)OC(C)C)C(C)C
CHEMBL1945848 acm2_human Human No 6.5 IC50 = 340 Funct
Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor
417 5 0 5 3.7 CC1=NN(C(=O)C=C1C2=CC=C(C=C2)OC3CCN(CC3)C4CCC4)C5=CC=CC=N5
CHEMBL1945848 acm2_human Human No 6.5 IC50 = 340 Funct
Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor
417 5 0 5 3.7 CC1=NN(C(=O)C=C1C2=CC=C(C=C2)OC3CCN(CC3)C4CCC4)C5=CC=CC=N5
CHEMBL167335 acm2_rat Rat Yes 4.5 IC50 = 34200 Funct
Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates
168 3 1 3 1.0 CC(CC#CCN(C)C)C=NO
CHEMBL59898 acm2_human Human Yes 5.5 IC50 = 3440.7 Funct
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
392 4 1 5 3.9 CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC)C
CHEMBL445 acm2_human Human Yes 6.5 IC50 = 347 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL3401646 acm2_human Human No 6.5 IC50 = 347.6 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
334 2 1 3 2.6 C1CN2CCC1C(C2)NC(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL3401646 acm2_human Human No 6.5 IC50 = 347.6 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
334 2 1 3 2.6 C1CN2CCC1C(C2)NC(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL3084674 acm2_human Human No 5.5 IC50 = 3478 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
377 6 1 2 4.7 CC(=O)NCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3084674 acm2_human Human No 5.5 IC50 = 3478 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
377 6 1 2 4.7 CC(=O)NCC(CC1CC2CCC(C1)N2C)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1779035 acm2_human Human No 6.5 IC50 = 349.3 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
288 5 0 3 3.2 CCCN(C1=CC=CC=C1)C(=O)OC2CN3CCC2CC3
CHEMBL1779035 acm2_human Human No 6.5 IC50 = 349.3 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
288 5 0 3 3.2 CCCN(C1=CC=CC=C1)C(=O)OC2CN3CCC2CC3
CHEMBL643 acm2_human Human Yes 7.5 IC50 = 35 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
284 3 0 3 4.8 CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
CHEMBL3401640 acm2_human Human No 7.5 IC50 = 35.1 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
336 4 2 3 2.7 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O
CHEMBL3401640 acm2_human Human No 7.5 IC50 = 35.1 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
336 4 2 3 2.7 C1CN2CCC1C(C2)NC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O
CHEMBL17671 acm2_rat Rat No 6.5 IC50 = 350 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
356 2 1 5 1.3 CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3NC(=O)C4=CSC=C42
CHEMBL17671 acm2_rat Rat No 6.5 IC50 = 350 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
356 2 1 5 1.3 CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3NC(=O)C4=CSC=C42
CHEMBL255523 acm2_rat Rat No 5.5 IC50 = 3500 Funct
Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay
364 6 1 3 4.5 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)CCC3CCCC3)Cl
CHEMBL255523 acm2_rat Rat No 5.5 IC50 = 3500 Funct
Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay
364 6 1 3 4.5 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)CCC3CCCC3)Cl
CHEMBL106782 acm2_rat Rat No 5.5 IC50 = 3500 Funct
Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine
438 11 2 9 4.7 CCCNC1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])NCCSCC2=CC=C(O2)CN(C)C
CHEMBL106932 acm2_rat Rat No 5.5 IC50 = 3500 Funct
Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue
451 10 2 10 4.0 CC(=NNC1=C(C=C(C(=C1)NCCSCC2=CC=C(O2)CN(C)C)[N+](=O)[O-])[N+](=O)[O-])C
CHEMBL1221512 acm2_human Human Yes 5.5 IC50 = 3568 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
560 19 4 9 2.6 CCC(C)C(COC(CC1=CC=CC=C1)C(=O)NC(CCS(=O)(=O)C)C(=O)OC(C)C)NCC(CS)N
CHEMBL2203713 acm2_human Human No 5.4 IC50 = 3600 Funct
Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor
326 3 2 4 2.9 C1CNCCC1N2CCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N
CHEMBL3085093 acm2_human Human No 6.4 IC50 = 362.7 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
381 5 0 5 3.8 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=C(C=C3)C#N)C4=CSC=C4
CHEMBL3085093 acm2_human Human No 6.4 IC50 = 362.7 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
381 5 0 5 3.8 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=C(C=C3)C#N)C4=CSC=C4
CHEMBL954 acm2_human Human Yes 5.4 IC50 = 3628 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
406 9 0 2 7.2 CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
CHEMBL954 acm2_human Human Yes 5.4 IC50 = 3628 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
406 9 0 2 7.2 CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
CHEMBL106082 acm2_rat Rat Yes 5.4 IC50 = 3700 Funct
Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue
497 10 2 10 5.0 CN(C)CC1=CC=C(O1)CSCCNC2=C(C=C(C(=C2)NC3=CC=CC=C3C#N)[N+](=O)[O-])[N+](=O)[O-]
CHEMBL2332280 acm2_rat Rat Yes 6.4 IC50 = 371.5 Funct
Antagonist activity at rat muscarinic M2 receptor isolated from brainAntagonist activity at rat muscarinic M2 receptor isolated from brain
277 4 0 1 5.1 C1CCN(CC1)CC=C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL900 acm2_human Human Yes 6.4 IC50 = 376 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
269 6 0 2 3.8 CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C
CHEMBL3085077 acm2_human Human No 7.4 IC50 = 38.2 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CS3)C4=CC=CC=C4
CHEMBL3085077 acm2_human Human No 7.4 IC50 = 38.2 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CS3)C4=CC=CC=C4
CHEMBL106348 acm2_rat Rat No 6.4 IC50 = 380 Funct
Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue
467 12 2 10 3.8 CN(C)CCNC1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])NCCSCC2=CC=C(O2)CN(C)C
CHEMBL978 acm2_rat Rat Yes 6.4 IC50 = 380 Funct
Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP
160 4 0 2 0.6 CC(C[N+](C)(C)C)OC(=O)C
CHEMBL978 acm2_human Human Yes 6.4 IC50 = 380 Funct
Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP
160 4 0 2 0.6 CC(C[N+](C)(C)C)OC(=O)C
CHEMBL27384 acm2_rat Rat Yes 4.4 IC50 = 38000 Funct
Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane
168 1 0 4 0.4 CN1CCC2=C(C1)C(=NO2)OC
CHEMBL1180343 acm2_human Human No 4.4 IC50 = 38484 Funct
Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay
365 8 0 4 4.0 CCN1CCC(=C(C1)C(=O)OCCC2=CC=C(C=C2)OC)C3=CC=CC=C3
CHEMBL86288 acm2_human Human No 4.4 IC50 = 38600 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
254 3 0 3 2.8 CC1=CC=C(C=C1)C#CCON=C2CN3CCC2C3
CHEMBL3085090 acm2_human Human No 7.4 IC50 = 39.1 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3)C4=CSC=C4
CHEMBL3085090 acm2_human Human No 7.4 IC50 = 39.1 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
356 5 0 4 4.1 CN1C2CCC1CC(C2)OC(=O)N(CC3=CC=CC=C3)C4=CSC=C4
CHEMBL1289314 acm2_human Human No 7.4 IC50 = 39.8 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
393 3 0 6 2.3 C1CN(CCC12CN(CCO2)C(=O)C3=NSN=C3)CC4=CC=C(C=C4)Cl
CHEMBL1289314 acm2_human Human No 7.4 IC50 = 39.8 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
393 3 0 6 2.3 C1CN(CCC12CN(CCO2)C(=O)C3=NSN=C3)CC4=CC=C(C=C4)Cl
CHEMBL12587 acm2_rat Rat Yes 5.4 IC50 = 3900 Funct
Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP
174 2 1 2 0.1 CC1C(CC(O1)C[N+](C)(C)C)O
CHEMBL12587 acm2_human Human Yes 5.4 IC50 = 3900 Funct
Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP
174 2 1 2 0.1 CC1C(CC(O1)C[N+](C)(C)C)O
CHEMBL386983 acm2_human Human No 6.4 IC50 = 398.1 Funct
Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation
532 19 0 14 1.1 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL451043 acm2_human Human No 6.4 IC50 = 398.1 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
573 12 5 7 3.9 C1CC1COC(=O)C2=CC=C(C=C2)NC(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC4CCN(C4)CC5=CC=C(C=C5)O
CHEMBL1083723 acm2_human Human No 6.4 IC50 = 398.1 Funct
Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells
343 4 2 2 4.1 CC1=C(C=C(C=C1)C2=CC=CC=C2C(=O)NCC3CCNCC3)Cl
CHEMBL386983 acm2_human Human No 6.4 IC50 = 398.1 Funct
Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation
532 19 0 14 1.1 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOCCOC3=NSN=C3OC
CHEMBL451043 acm2_human Human No 6.4 IC50 = 398.1 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
573 12 5 7 3.9 C1CC1COC(=O)C2=CC=C(C=C2)NC(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC4CCN(C4)CC5=CC=C(C=C5)O
CHEMBL1083723 acm2_human Human No 6.4 IC50 = 398.1 Funct
Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells
343 4 2 2 4.1 CC1=C(C=C(C=C1)C2=CC=CC=C2C(=O)NCC3CCNCC3)Cl
CHEMBL167438 acm2_human Human No 5.4 IC50 = 3980 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
168 3 0 3 1.5 CCCON=C1CN2CCC1C2
CHEMBL1084993 acm2_human Human No 5.4 IC50 = 3981.1 Funct
Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells
343 4 2 2 4.2 CC1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL1084993 acm2_human Human No 5.4 IC50 = 3981.1 Funct
Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells
343 4 2 2 4.2 CC1CNCCC1CNC(=O)C2=CC=CC=C2C3=CC(=CC=C3)Cl
CHEMBL3401643 acm2_human Human No 8.4 IC50 = 4.2 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
334 4 2 4 2.6 C1CCC(C1)C(C2=CC=CS2)(C(=O)NC3CN4CCC3CC4)O
CHEMBL3401643 acm2_human Human No 8.4 IC50 = 4.2 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
334 4 2 4 2.6 C1CCC(C1)C(C2=CC=CS2)(C(=O)NC3CN4CCC3CC4)O
CHEMBL194837 acm2_human Human No 8.4 IC50 = 4.5 Funct
Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2
448 8 1 5 5.0 CC1=CC(=NC2=C1C=C(C=C2)NC(=O)COC3=C(C=C(C=C3)Cl)Cl)OCCN(C)C
CHEMBL194837 acm2_human Human No 8.4 IC50 = 4.5 Funct
Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2
448 8 1 5 5.0 CC1=CC(=NC2=C1C=C(C=C2)NC(=O)COC3=C(C=C(C=C3)Cl)Cl)OCCN(C)C
CHEMBL1779034 acm2_human Human No 8.3 IC50 = 4.7 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
342 5 0 4 3.5 C1CN2CCC1C(C2)OC(=O)N(CC3=CSC=C3)C4=CC=CC=C4
CHEMBL1779034 acm2_human Human No 8.3 IC50 = 4.7 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
342 5 0 4 3.5 C1CN2CCC1C(C2)OC(=O)N(CC3=CSC=C3)C4=CC=CC=C4
CHEMBL297818 acm2_rat Rat No 7.4 IC50 = 40 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
456 6 1 5 2.6 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=CC(=C3)Cl)C(=O)NC4=C2N=CC=C4
CHEMBL297818 acm2_rat Rat No 7.4 IC50 = 40 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
456 6 1 5 2.6 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=CC(=C3)Cl)C(=O)NC4=C2N=CC=C4
CHEMBL418712 acm2_mouse Mouse No 6.4 IC50 = 400 Funct
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex
467 18 0 6 5.5 CN(C)CC1=CC=C(O1)CSCCCCCCCCCSCC2=CC=C(O2)CN(C)C
CHEMBL107673 acm2_rat Rat No 6.4 IC50 = 400 Funct
Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue
487 11 2 10 4.2 CN(C)CC1=CC=C(O1)CSCCNC2=C(C=C(C(=C2)NCC3=CN=CC=C3)[N+](=O)[O-])[N+](=O)[O-]
CHEMBL85264 acm2_human Human No 5.4 IC50 = 4010 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
275 3 0 3 3.1 C1CN2CC1C(=NOCC#CC3=CC=CC=C3Cl)C2
CHEMBL2206602 acm2_human Human No 6.4 IC50 = 405.1 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
693 15 4 5 6.9 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCC[N+](C)(CC3=CC=C(C=C3)Cl)CC4=CC=C(C=C4)Cl
CHEMBL3085085 acm2_human Human No 6.4 IC50 = 409.8 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
371 5 0 4 4.5 CC1=CC=C(S1)CN(C2=CC=CC=C2)C(=O)OC3CC4CCC(C3)N4C
CHEMBL3085085 acm2_human Human No 6.4 IC50 = 409.8 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
371 5 0 4 4.5 CC1=CC=C(S1)CN(C2=CC=CC=C2)C(=O)OC3CC4CCC(C3)N4C
CHEMBL2206591 acm2_human Human No 7.4 IC50 = 41.2 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
724 12 3 5 7.3 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CC[N+](CC3)(CC4CCC5=CC=CC=C5C4)CC6=CC=C(C=C6)Cl
CHEMBL2207176 acm2_human Human No 6.4 IC50 = 410.6 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
612 14 4 5 5.7 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCCC[N+](C)(C)CC3=CC4=CC=CC=C4C=C3
CHEMBL1779032 acm2_human Human No 7.4 IC50 = 42.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
350 6 0 3 4.3 C1CN2CCC1C(C2)OC(=O)N(CCC3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1779032 acm2_human Human No 7.4 IC50 = 42.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
350 6 0 3 4.3 C1CN2CCC1C(C2)OC(=O)N(CCC3=CC=CC=C3)C4=CC=CC=C4
CHEMBL2206587 acm2_human Human No 6.4 IC50 = 427 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
604 10 3 7 3.9 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CC[N+](CC3)(C)CC4=CC5=C(C=C4)OCO5
CHEMBL91 acm2_human Human Yes 5.4 IC50 = 4336 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
416 6 0 2 5.3 C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
CHEMBL91 acm2_human Human Yes 5.4 IC50 = 4336 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
416 6 0 2 5.3 C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
CHEMBL107254 acm2_rat Rat No 5.4 IC50 = 4400 Funct
Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue
490 10 2 10 5.4 CN(C)CC1=CC=C(O1)CSCCNC2=C(C=C(C(=C2)NC3=CC=C(C=C3)F)[N+](=O)[O-])[N+](=O)[O-]
CHEMBL75358 acm2_rat Rat Yes 5.4 IC50 = 4460 Funct
Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates
168 2 0 2 -0.2 CC(=O)N(C)CC#CCN(C)C
CHEMBL166593 acm2_human Human No 5.4 IC50 = 4460 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
182 2 0 3 1.5 CC(C)(C)ON=C1CN2CCC1C2
CHEMBL12587 acm2_human Human Yes 6.4 IC50 = 449 Funct
Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP
174 2 1 2 0.1 CC1C(CC(O1)C[N+](C)(C)C)O
CHEMBL1779045 acm2_human Human No 7.3 IC50 = 45.8 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
404 5 0 6 4.5 CC1=CC(=CC=C1)N(CC2=CC(=C(C=C2F)F)F)C(=O)OC3CN4CCC3CC4
CHEMBL1779045 acm2_human Human No 7.3 IC50 = 45.8 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting
404 5 0 6 4.5 CC1=CC(=CC=C1)N(CC2=CC(=C(C=C2F)F)F)C(=O)OC3CN4CCC3CC4
CHEMBL7303 acm2_human Human Yes 5.4 IC50 = 4500 Funct
Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL115280 acm2_human Human No 5.3 IC50 = 4540 Funct
Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2
414 5 1 4 4.3 C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CC4=CC(=CC=C4)OC5=CC=CC=C5
CHEMBL60142 acm2_human Human No 5.3 IC50 = 4563.5 Funct
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
378 4 1 5 3.5 CCOC(=O)C1=CNC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC
CHEMBL2306159 acm2_human Human No 6.3 IC50 = 458 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
475 8 1 4 6.1 CN1C2CCC1CC(C2)CC(CNS(=O)(=O)C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2306159 acm2_human Human No 6.3 IC50 = 458 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
475 8 1 4 6.1 CN1C2CCC1CC(C2)CC(CNS(=O)(=O)C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1123 acm2_human Human Yes 7.3 IC50 = 46 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 8 0 3 5.5 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
CHEMBL1123 acm2_human Human Yes 7.3 IC50 = 46 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
309 8 0 3 5.5 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
CHEMBL86197 acm2_human Human No 4.3 IC50 = 46600 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
285 3 0 5 2.3 C1CN2CC1C(=NOCC#CC3=CC(=CC=C3)[N+](=O)[O-])C2
CHEMBL61774 acm2_human Human No 5.3 IC50 = 4662.4 Funct
Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
348 2 1 4 3.5 CC1=C(C2=C(N1)C=CC3=C2CN4CCC5=CC=CC=C5C4O3)C(=O)OC
CHEMBL3085088 acm2_human Human No 6.3 IC50 = 467.7 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
354 5 0 4 3.9 CC1=C(OC=C1)CN(C2=CC=CC=C2)C(=O)OC3CC4CCC(C3)N4C
CHEMBL3085088 acm2_human Human No 6.3 IC50 = 467.7 Funct
Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization
354 5 0 4 3.9 CC1=C(OC=C1)CN(C2=CC=CC=C2)C(=O)OC3CC4CCC(C3)N4C
CHEMBL60833 acm2_rat Rat No 7.3 IC50 = 47 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
344 4 0 5 3.2 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC(=CC=C5)Cl
CHEMBL12858 acm2_mouse Mouse Yes 6.3 IC50 = 470 Funct
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex
479 16 2 8 1.8 CN(C)CC1=CC=C(O1)CSCCNC(=NCCSCC2=CC=C(O2)CN(C)C)NC#N
CHEMBL321605 acm2_rat Rat No 5.3 IC50 = 4700 Funct
Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue
410 9 3 10 3.0 CN(C)CC1=CC=C(O1)CSCCNC2=CC(=C(C=C2[N+](=O)[O-])[N+](=O)[O-])NN
CHEMBL42 acm2_human Human Yes 6.3 IC50 = 476 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL42 acm2_human Human Yes 6.3 IC50 = 476 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL85460 acm2_human Human No 4.3 IC50 = 47900 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
258 3 0 4 2.6 C1CN2CC1C(=NOCC#CC3=CC(=CC=C3)F)C2
CHEMBL189118 acm2_human Human No 6.3 IC50 = 480 Funct
Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2
473 8 1 8 5.5 CC1=CC(=NC2=C1C=C(C=C2)NC(=O)C=CC3=CC=C(C=C3)OC(F)(F)F)N(C)CCN(C)C
CHEMBL15944 acm2_human Human No 6.3 IC50 = 480 Funct
Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2
227 2 0 5 1.5 CN1CCC=C(C1)C2=NSN=C2SC
CHEMBL189118 acm2_human Human No 6.3 IC50 = 480 Funct
Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2
473 8 1 8 5.5 CC1=CC(=NC2=C1C=C(C=C2)NC(=O)C=CC3=CC=C(C=C3)OC(F)(F)F)N(C)CCN(C)C
CHEMBL120972 acm2_human Human No 6.3 IC50 = 486.1 Funct
Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells
358 12 0 3 6.0 CCCCCCCCCOC(=O)C1CN(CC=C1C2=CC=CC=C2)CC
CHEMBL303360 acm2_rat Rat No 7.3 IC50 = 49 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
360 4 0 5 3.7 C1C2C3C2(CN1C3)C4=NSN=C4SCC#CC5=CC(=CC=C5)Cl
CHEMBL12587 acm2_rat Rat Yes 6.3 IC50 = 490 Funct
Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP
174 2 1 2 0.1 CC1C(CC(O1)C[N+](C)(C)C)O
CHEMBL413966 acm2_rat Rat No 7.3 IC50 = 50 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
336 2 1 4 0.6 CN1CCC(C1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL17045 acm2_rat Rat Yes 7.3 IC50 = 50 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
422 6 1 5 2.0 CCN(CC)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL413966 acm2_rat Rat No 7.3 IC50 = 50 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
336 2 1 4 0.6 CN1CCC(C1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL1290753 acm2_human Human No 7.3 IC50 = 50.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
389 3 0 4 3.3 CC1=CC=C(O1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL1289544 acm2_human Human No 7.3 IC50 = 50.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
392 3 0 5 2.9 C1CN(CCC12CN(CCO2)C(=O)C3=CSC=N3)CC4=CC=C(C=C4)Cl
CHEMBL1290753 acm2_human Human No 7.3 IC50 = 50.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
389 3 0 4 3.3 CC1=CC=C(O1)C(=O)N2CCOC3(C2)CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL1289544 acm2_human Human No 7.3 IC50 = 50.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
392 3 0 5 2.9 C1CN(CCC12CN(CCO2)C(=O)C3=CSC=N3)CC4=CC=C(C=C4)Cl
CHEMBL279135 acm2_rat Rat No 6.3 IC50 = 500 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
338 5 1 4 0.9 CN(C)CCCCC(=O)N1C2=CC=CC=C2C(=O)NC3=C1N=CC=C3
CHEMBL279135 acm2_rat Rat No 6.3 IC50 = 500 Funct
Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
338 5 1 4 0.9 CN(C)CCCCC(=O)N1C2=CC=CC=C2C(=O)NC3=C1N=CC=C3
CHEMBL13206 acm2_mouse Mouse No 6.3 IC50 = 500 Funct
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex
498 16 2 10 2.7 CN(C)CC1=CC=C(O1)CSCCNC=C(NCCSCC2=CC=C(O2)CN(C)C)[N+](=O)[O-]
CHEMBL47575 acm2_rat Rat No 5.3 IC50 = 5000 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
408 4 1 4 1.9 CCN(CC)CC1CCCCN1C(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL47575 acm2_rat Rat No 5.3 IC50 = 5000 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
408 4 1 4 1.9 CCN(CC)CC1CCCCN1C(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL505453 acm2_human Human No 5.3 IC50 = 5011.9 Funct
Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL505453 acm2_human Human No 5.3 IC50 = 5011.9 Funct
Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
547 11 5 7 3.5 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC=C(C=C4)O
CHEMBL633 acm2_human Human Yes 5.3 IC50 = 5080 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
645 11 0 4 7.6 CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I
CHEMBL633 acm2_human Human Yes 5.3 IC50 = 5080 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
645 11 0 4 7.6 CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I
CHEMBL168561 acm2_human Human No 5.3 IC50 = 5080 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
216 2 0 3 1.9 CC#CCC#CCON=C1CN2CCC1C2
CHEMBL114379 acm2_human Human No 6.3 IC50 = 518 Funct
Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2
386 3 1 4 3.3 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC5=C(C=C4Cl)OCO5
CHEMBL312823 acm2_human Human No 6.3 IC50 = 519 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
190 3 0 3 1.3 C#CC=CCON=C1CN2CCC1C2
CHEMBL82378 acm2_human Human No 6.3 IC50 = 519 Funct
Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2
194 3 0 3 2.1 CC(=CCON=C1CN2CCC1C2)C
CHEMBL13166 acm2_mouse Mouse No 6.3 IC50 = 520 Funct
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex
411 14 0 6 3.5 CN(C)CC1=CC=C(O1)CSCCCCCSCC2=CC=C(O2)CN(C)C
CHEMBL978 acm2_rat Rat Yes 5.3 IC50 = 5200 Funct
Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP
160 4 0 2 0.6 CC(C[N+](C)(C)C)OC(=O)C
CHEMBL978 acm2_human Human Yes 5.3 IC50 = 5200 Funct
Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP
160 4 0 2 0.6 CC(C[N+](C)(C)C)OC(=O)C
CHEMBL255169 acm2_rat Rat Yes 4.3 IC50 = 52000 Funct
Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay
372 6 1 3 3.9 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)CCC3=CC=CC=C3)Cl
CHEMBL255169 acm2_rat Rat Yes 4.3 IC50 = 52000 Funct
Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay
372 6 1 3 3.9 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)CCC3=CC=CC=C3)Cl
CHEMBL81878 acm2_human Human No 4.3 IC50 = 52000 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
270 4 0 4 2.4 COC1=CC=CC(=C1)C#CCON=C2CN3CCC2C3
CHEMBL166537 acm2_human Human No 5.3 IC50 = 5280 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
178 2 0 3 1.1 CC(C#C)ON=C1CN2CCC1C2
CHEMBL490 acm2_human Human Yes 6.3 IC50 = 532 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
329 4 1 5 3.5 C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4
CHEMBL490 acm2_human Human Yes 6.3 IC50 = 532 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
329 4 1 5 3.5 C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4
CHEMBL3084638 acm2_human Human No 5.3 IC50 = 5345 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
378 6 2 2 4.1 CN1C2CCC1CC(C2)CC(CNC(=O)N)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL3084638 acm2_human Human No 5.3 IC50 = 5345 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
378 6 2 2 4.1 CN1C2CCC1CC(C2)CC(CNC(=O)N)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL418714 acm2_mouse Mouse No 6.3 IC50 = 540 Funct
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex
453 17 0 6 5.0 CN(C)CC1=CC=C(O1)CSCCCCCCCCSCC2=CC=C(O2)CN(C)C
CHEMBL2308786 acm2_human Human No 6.3 IC50 = 545 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
439 7 1 2 5.9 CN1C2CCC1CC(C2)CC(C3=CC=CC=C3)(C4=CC=CC=C4)C(=O)NCC5=CC=CC=C5
CHEMBL2308786 acm2_human Human No 6.3 IC50 = 545 Funct
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
439 7 1 2 5.9 CN1C2CCC1CC(C2)CC(C3=CC=CC=C3)(C4=CC=CC=C4)C(=O)NCC5=CC=CC=C5
CHEMBL2206603 acm2_human Human No 6.3 IC50 = 548.8 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
582 13 4 5 4.7 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NCC[N+](C)(C)CC3=CC=C(C=C3)Cl
CHEMBL12472 acm2_mouse Mouse No 6.3 IC50 = 550 Funct
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex
445 12 0 6 3.8 CN(C)CC1=CC=C(O1)CSCC2=CC=C(C=C2)CSCC3=CC=C(O3)CN(C)C
CHEMBL163661 acm2_rat Rat Yes 5.3 IC50 = 5500 Funct
Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates
194 3 1 3 1.5 CC(CC#CCN1CCCC1)C=NO
CHEMBL2206601 acm2_human Human No 6.3 IC50 = 555.9 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
552 10 3 5 4.2 CC[N+]1(CCCC1)C2CCN(CC2)C(=O)C(CC3=CC=C(C=C3)O)NC(=O)NC4=CC=C(C=C4)C(=O)OC(C)C
CHEMBL410928 acm2_rat Rat No 6.3 IC50 = 560 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
420 4 1 5 1.7 C1CCN(C(C1)CN2CCCC2)CC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL410928 acm2_rat Rat No 6.3 IC50 = 560 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
420 4 1 5 1.7 C1CCN(C(C1)CN2CCCC2)CC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL395110 acm2_human Human Yes 6.3 IC50 = 565 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
310 2 0 3 5.6 CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
CHEMBL316973 acm2_rat Rat Yes 5.2 IC50 = 5700 Funct
Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue
380 8 1 8 3.2 CN(C)CC1=CC=C(O1)CSCCNC2=C(C=C(C=C2)[N+](=O)[O-])[N+](=O)[O-]
CHEMBL2206590 acm2_human Human No 7.2 IC50 = 58.8 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
676 12 3 5 7.1 CC(C)OC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CC[N+](CC3)(CC4CCCCC4)CC5=CC=C(C=C5)Cl
CHEMBL268499 acm2_mouse Mouse No 6.2 IC50 = 580 Funct
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex
425 15 0 6 3.9 CN(C)CC1=CC=C(O1)CSCCCCCCSCC2=CC=C(O2)CN(C)C
CHEMBL13122 acm2_mouse Mouse No 6.2 IC50 = 590 Funct
Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex
593 16 2 12 4.9 CN(C)CC1=CC=C(O1)CSCCNC2=CC(=C(C=C2[N+](=O)[O-])[N+](=O)[O-])NCCSCC3=CC=C(O3)CN(C)C
CHEMBL7303 acm2_rat Rat Yes 6.2 IC50 = 590 Funct
Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart
155 2 0 3 0.3 CN1CCC=C(C1)C(=O)OC
CHEMBL168991 acm2_human Human No 4.2 IC50 = 59300 Funct
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
208 3 0 4 0.5 COCC#CCON=C1CN2CCC1C2
CHEMBL477542 acm2_human Human No 8.2 IC50 = 6 Funct
Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor
327 14 5 4 -0.7 C(CCCCN=C(N)N)CCCC(=O)C(CCCN=C(N)N)N
CHEMBL477542 acm2_human Human No 8.2 IC50 = 6 Funct
Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor
327 14 5 4 -0.7 C(CCCCN=C(N)N)CCCC(=O)C(CCCN=C(N)N)N
CHEMBL1290294 acm2_human Human No 8.2 IC50 = 6.3 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
348 3 0 2 4.0 C1CN(CCC12CCN(CC2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4
CHEMBL1290294 acm2_human Human No 8.2 IC50 = 6.3 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
348 3 0 2 4.0 C1CN(CCC12CCN(CC2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4
CHEMBL299142 acm2_rat Rat No 7.2 IC50 = 60 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
450 8 1 5 2.7 CCN(CC)CCCC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL44773 acm2_rat Rat No 7.2 IC50 = 60 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
462 5 1 5 3.0 CN(CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4)C5CCCCC5
CHEMBL299142 acm2_rat Rat No 7.2 IC50 = 60 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
450 8 1 5 2.7 CCN(CC)CCCC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL44773 acm2_rat Rat No 7.2 IC50 = 60 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
462 5 1 5 3.0 CN(CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4)C5CCCCC5
CHEMBL321808 acm2_rat Rat No 6.2 IC50 = 600 Funct
Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine
337 8 1 8 1.7 CN(C)CC1=CC=C(O1)CSCCNC2=C(C=CN=N2)[N+](=O)[O-]
CHEMBL45983 acm2_rat Rat No 6.2 IC50 = 600 Funct
Binding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligand
434 4 1 5 2.1 C1CCN(CC1)CC2CCCCN2CC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL296365 acm2_rat Rat No 6.2 IC50 = 600 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
393 5 2 5 1.1 CCNCC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL296365 acm2_rat Rat No 6.2 IC50 = 600 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
393 5 2 5 1.1 CCNCC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL45983 acm2_rat Rat No 6.2 IC50 = 600 Funct
Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria
434 4 1 5 2.1 C1CCN(CC1)CC2CCCCN2CC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL2112418 acm2_rat Rat No 5.2 IC50 = 6000 Funct
Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.
390 2 1 4 1.8 C1CCN2CCCC(C2C1)CC(=O)N3C4=CC=CC=C4C(=O)NC5=C3N=CC=C5
CHEMBL87622 acm2_human Human No 5.2 IC50 = 6010 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
204 4 0 3 1.9 CC(=CCON=C1CN2CCC1C2)C#C
CHEMBL315676 acm2_human Human No 5.2 IC50 = 6030 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
164 2 0 3 0.7 C#CCON=C1CN2CCC1C2
CHEMBL137384 acm2_human Human No 6.2 IC50 = 610 Funct
In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2
179 2 0 4 0.6 CON=C(C#N)C1CN2CCC1C2
CHEMBL257991 acm2_human Human Yes 5.2 IC50 = 6280 Funct
Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor
470 5 2 7 3.2 C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5
CHEMBL257991 acm2_human Human Yes 5.2 IC50 = 6280 Funct
Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor
470 5 2 7 3.2 C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5
CHEMBL60101 acm2_rat Rat No 7.2 IC50 = 63 Funct
Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
344 4 0 5 3.2 C1C2C3C2(CN1C3)C4=NSN=C4OCC#CC5=CC=C(C=C5)Cl
CHEMBL1289202 acm2_human Human No 7.2 IC50 = 63.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
375 3 0 4 2.6 C1CN(CCC12CN(CCO2)C(=O)C3=COC=C3)CC4=CC=C(C=C4)Cl
CHEMBL1289202 acm2_human Human No 7.2 IC50 = 63.1 Funct
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay
375 3 0 4 2.6 C1CN(CCC12CN(CCO2)C(=O)C3=COC=C3)CC4=CC=C(C=C4)Cl
CHEMBL443925 acm2_human Human No 6.2 IC50 = 631.0 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
599 11 4 9 4.7 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)C(F)(F)F
CHEMBL443925 acm2_human Human No 6.2 IC50 = 631.0 Funct
Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay
599 11 4 9 4.7 CCOC(=O)C1=CC=C(C=C1)NC(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3CCN(C3)CC4=CC(=CC=C4)C(F)(F)F
CHEMBL108163 acm2_rat Rat No 5.2 IC50 = 6400 Funct
Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue
472 10 2 9 5.3 CN(C)CC1=CC=C(O1)CSCCNC2=C(C=C(C(=C2)NC3=CC=CC=C3)[N+](=O)[O-])[N+](=O)[O-]
CHEMBL3401644 acm2_human Human No 5.2 IC50 = 6455 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
294 4 2 4 1.6 CCC(C1=CC=CS1)(C(=O)NC2CN3CCC2CC3)O
CHEMBL3401644 acm2_human Human No 5.2 IC50 = 6455 Funct
Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method
294 4 2 4 1.6 CCC(C1=CC=CS1)(C(=O)NC2CN3CCC2CC3)O
CHEMBL29835 acm2_rat Rat Yes 6.2 IC50 = 650 Funct
Inhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)PInhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)P
251 4 0 2 3.9 CCCN(C1=CC=NC=C1)N2C=CC3=CC=CC=C32
CHEMBL353023 acm2_rat Rat Yes 5.2 IC50 = 6500 Funct
Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates
193 3 0 2 1.5 CC(CC#CCN1CCCC1)C(=O)C
CHEMBL71 acm2_human Human Yes 6.2 IC50 = 652 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL71 acm2_human Human Yes 6.2 IC50 = 652 Funct
DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL15936 acm2_human Human No 5.2 IC50 = 6700 Funct
Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2
191 0 1 4 1.2 C1CNCC2=C1C=CC3=NSN=C23
CHEMBL107892 acm2_rat Rat No 5.2 IC50 = 6800 Funct
Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine
395 8 2 9 3.1 CN(C)CC1=CC=C(O1)CSCCNC2=C(C=C(C(=C2)N)[N+](=O)[O-])[N+](=O)[O-]
CHEMBL103529 acm2_rat Rat No 5.2 IC50 = 6800 Funct
Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.
390 2 1 4 2.6 C1CCN2CCCC(C2C1)CC(=O)N3C4=CC=CC=C4NC(=O)C5=C3N=CC=C5
CHEMBL9967 acm2_rat Rat Yes 6.2 IC50 = 690 Funct
Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.
351 2 1 5 0.1 CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
CHEMBL1092461 acm2_human Human Yes 5.2 IC50 = 6900 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization
358 4 1 3 4.1 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC=C(C=C3)C)Cl
CHEMBL1092461 acm2_human Human Yes 5.2 IC50 = 6900 Funct
Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization
358 4 1 3 4.1 CCN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC=C(C=C3)C)Cl
CHEMBL86150 acm2_human Human No 4.2 IC50 = 69300 Funct
Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
270 4 0 4 2.4 COC1=CC=CC=C1C#CCON=C2CN3CCC2C3
CHEMBL216983 acm2_human Human No 8.1 IC50 = 7.9 Funct
Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation
373 13 1 9 -0.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCO
CHEMBL216983 acm2_human Human No 8.1 IC50 = 7.9 Funct
Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation
373 13 1 9 -0.2 CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCO
CHEMBL294919 acm2_rat Rat No 7.2 IC50 = 70 Funct
Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand
436 6 1 5 2.3 CCN(CC)CC1CCCCN1CC(=O)N2C3=C(C=CC(=C3)C)C(=O)NC4=C2N=CC=C4
CHEMBL294919 acm2_rat Rat No 7.2 IC50 = 70 Funct