Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Unit Assay Type Assay Description Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles
CHEMBL416012 adrb1_human Human No 9.9 EC50 = 0.1 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
359 7 3 3 3.8 CC(CC1=CNC2=C1C=CC=C2OC)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL26183 adrb1_human Human No 9.9 EC50 = 0.1 Funct
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
359 7 3 3 3.8 CC(CC1=CNC2=C1C=CC=C2OC)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL1256786 b0fl73_cavpo Guinea pig Yes 9.5 EC50 = 0.3 Funct
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
344 8 4 5 1.8 CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
CHEMBL1256786 b0fl73_cavpo Guinea pig Yes 9.5 EC50 = 0.3 Funct
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
344 8 4 5 1.8 CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
CHEMBL1257913 adrb1_human Human No 9.2 EC50 = 0.6 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
477 8 3 8 4.5 C1CN(CCC1NCC(COC2=CC=CC(=C2)O)O)C3=C4C(=CSC4=NC=N3)C5=CC=CC=C5
CHEMBL1257913 adrb1_human Human No 9.2 EC50 = 0.6 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
477 8 3 8 4.5 C1CN(CCC1NCC(COC2=CC=CC(=C2)O)O)C3=C4C(=CSC4=NC=N3)C5=CC=CC=C5
CHEMBL579394 adrb1_human Human No 9.2 EC50 = 0.6 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
370 6 4 5 2.2 CC1=CC=CC=C1CC(C)(C)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL579394 adrb1_human Human No 9.2 EC50 = 0.6 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
370 6 4 5 2.2 CC1=CC=CC=C1CC(C)(C)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL567863 adrb1_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
356 6 4 5 1.8 CC(C)(CC1=CC=CC=C1)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL567863 adrb1_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
356 6 4 5 1.8 CC(C)(CC1=CC=CC=C1)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL568272 adrb1_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
372 6 5 6 1.5 CC(C)(CC1=CC=C(C=C1)O)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL568272 adrb1_human Human No 9.1 EC50 = 0.9 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
372 6 5 6 1.5 CC(C)(CC1=CC=C(C=C1)O)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL369346 adrb1_human Human No 9.1 EC50 = 0.9 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
481 11 5 7 2.6 C1=CC=C(C=C1)OCC(CNC(CC2=CC=C(C=C2)NC(=O)NC3=CC(=CC=C3)[N+](=O)[O-])CO)O
CHEMBL186271 adrb1_human Human No 8.9 EC50 = 1.2 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
618 12 4 10 4.8 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C3=CC=CS3)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL189081 adrb1_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
613 12 4 10 3.7 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C3=CN=CC=C3)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL272234 adrb1_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
413 9 3 6 1.3 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)OC3=NC=C(C=C3)C(=O)O)O
CHEMBL272234 adrb1_human Human No 8.9 EC50 = 1.4 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
413 9 3 6 1.3 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)OC3=NC=C(C=C3)C(=O)O)O
CHEMBL3298987 adrb1_human Human No 8.8 EC50 = 1.6 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
579 12 6 7 4.5 CC(C)(COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)C5=CC=CC=C5)N
CHEMBL3298987 adrb1_human Human No 8.8 EC50 = 1.6 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
579 12 6 7 4.5 CC(C)(COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)C5=CC=CC=C5)N
CHEMBL577917 adrb1_human Human No 8.7 EC50 = 1.8 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
499 11 7 7 -0.3 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCN=C(N)N)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL1258026 adrb1_human Human No 8.7 EC50 = 1.8 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
483 8 3 9 4.2 C1CN(CCC1NCC(COC2=CC=C(C=C2)O)O)C3=C4C(=CSC4=NC=N3)C5=CC=CS5
CHEMBL577917 adrb1_human Human No 8.8 EC50 = 1.8 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
499 11 7 7 -0.3 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCN=C(N)N)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL1258026 adrb1_human Human No 8.8 EC50 = 1.8 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
483 8 3 9 4.2 C1CN(CCC1NCC(COC2=CC=C(C=C2)O)O)C3=C4C(=CSC4=NC=N3)C5=CC=CS5
CHEMBL26393 adrb1_human Human No 8.7 EC50 = 1.9 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
329 6 3 2 3.8 CC(CC1=CNC2=CC=CC=C21)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL26393 adrb1_human Human No 8.7 EC50 = 1.9 Funct
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
329 6 3 2 3.8 CC(CC1=CNC2=CC=CC=C21)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL3298762 adrb1_human Human No 8.7 EC50 = 2.0 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
579 13 6 7 4.1 C1=CC=C(C=C1)C(=O)NCCOC2=CC=C(C=C2)NC3=CC=C(C=C3)CCNCC(C4=C5C=CC(=O)NC5=C(C=C4)O)O
CHEMBL3298762 adrb1_human Human No 8.7 EC50 = 2.0 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
579 13 6 7 4.1 C1=CC=C(C=C1)C(=O)NCCOC2=CC=C(C=C2)NC3=CC=C(C=C3)CCNCC(C4=C5C=CC(=O)NC5=C(C=C4)O)O
CHEMBL3298897 adrb1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
544 12 6 8 2.5 C1CN(CCN1)CCOC2=CC=C(C=C2)NC3=CC=C(C=C3)CCNCC(C4=C5C=CC(=O)NC5=C(C=C4)O)O
CHEMBL3290998 adrb1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
498 11 5 6 4.6 COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NC=O)O)C4=CC=CC=C4
CHEMBL425161 adrb1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
458 11 4 6 3.6 CC=CCNC1=CC=CC(=C1)C(CNC(C)CC2=CNC3=C2C=CC=C3OS(=O)(=O)C)O
CHEMBL3298897 adrb1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
544 12 6 8 2.5 C1CN(CCN1)CCOC2=CC=C(C=C2)NC3=CC=C(C=C3)CCNCC(C4=C5C=CC(=O)NC5=C(C=C4)O)O
CHEMBL3290998 adrb1_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
498 11 5 6 4.6 COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NC=O)O)C4=CC=CC=C4
CHEMBL1807869 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
482 13 5 7 3.2 C1=CC(=CC(=C1)Cl)CCNCCSCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1807827 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
482 13 5 7 3.2 C1=CC(=CC(=C1)Cl)CCNCCCSCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1807829 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
516 13 5 7 3.8 C1=CC(=C(C(=C1)Cl)Cl)CCNCCCSCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1807828 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
482 13 5 7 3.2 C1=CC=C(C(=C1)CCNCCCSCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O)Cl
CHEMBL393470 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
432 9 4 7 1.7 CC(CNC1=CC=CC(=C1)C2=CSC(=N2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL245673 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
415 9 4 6 1.4 CC(CNC1=CC=CC(=C1)C2=C(C=CO2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL395834 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
431 9 4 6 2.0 CC(CNC1=CC=C(C=C1)C2=C(C=CS2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL1084655 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
497 17 5 9 1.1 C1=CC(=CC=C1COCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O)S(=O)(=O)N
CHEMBL157210 adrb1_human Human No 7.0 EC50 = 100 Funct
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
440 10 4 6 2.2 CC(CNC1=CC=C(C=C1)CC(=O)NS(=O)(=O)C)NCC(C2=CC(=CC=C2)Cl)O
CHEMBL1807869 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
482 13 5 7 3.2 C1=CC(=CC(=C1)Cl)CCNCCSCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1807827 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
482 13 5 7 3.2 C1=CC(=CC(=C1)Cl)CCNCCCSCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1807829 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
516 13 5 7 3.8 C1=CC(=C(C(=C1)Cl)Cl)CCNCCCSCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1807828 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
482 13 5 7 3.2 C1=CC=C(C(=C1)CCNCCCSCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O)Cl
CHEMBL393470 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
432 9 4 7 1.7 CC(CNC1=CC=CC(=C1)C2=CSC(=N2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL245673 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
415 9 4 6 1.4 CC(CNC1=CC=CC(=C1)C2=C(C=CO2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL395834 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
431 9 4 6 2.0 CC(CNC1=CC=C(C=C1)C2=C(C=CS2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL1084655 adrb1_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
497 17 5 9 1.1 C1=CC(=CC=C1COCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O)S(=O)(=O)N
CHEMBL284612 adrb1_human Human No 7.0 EC50 = 100 Funct
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
507 10 6 10 -1.2 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNC2CCN(CC2)C3=CC=C(C=C3)NC(=O)CC(=O)O)O)O
CHEMBL475237 adrb1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
509 18 5 8 2.4 C1=CC(=CC(=C1)CS(=O)(=O)N)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O
CHEMBL475237 adrb1_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
509 18 5 8 2.4 C1=CC(=CC(=C1)CS(=O)(=O)N)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O
CHEMBL101606 adrb1_human Human No 6.0 EC50 = 1000 Funct
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
594 11 5 12 -1.9 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNCC2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)N4C=C(C=N4)C(=O)O)O)O
CHEMBL207943 adrb1_human Human No 5.0 EC50 = 10000 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
412 9 4 6 0.8 C1=CC(=CC(=C1)NCCNCC(C2=CC(=CC=C2)Cl)O)C3=C(C=CN=C3)C(=O)O
CHEMBL1682221 adrb1_rat Rat No 5.0 EC50 = 10000 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
551 10 6 6 3.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)NC(=O)NC3=CC=CC(=C3)CCNCC(C4=C5C=CC(=O)NC5=C(C=C4)O)O
CHEMBL207943 adrb1_human Human No 5.0 EC50 = 10000 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
412 9 4 6 0.8 C1=CC(=CC(=C1)NCCNCC(C2=CC(=CC=C2)Cl)O)C3=C(C=CN=C3)C(=O)O
CHEMBL1682221 adrb1_rat Rat No 5.0 EC50 = 10000 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
551 10 6 6 3.7 C1=CC=C(C=C1)OC2=CC=CC(=C2)NC(=O)NC3=CC=CC(=C3)CCNCC(C4=C5C=CC(=O)NC5=C(C=C4)O)O
CHEMBL308868 adrb1_human Human No 5.0 EC50 = 10000 Funct
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
629 12 6 7 6.1 CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC(=C2)C3=CC(=CC=C3)CC4C5=CC(=C(C=C5CCN4)O)O
CHEMBL306423 adrb1_human Human No 4.0 EC50 = 100000 Funct
Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells
510 9 3 7 4.2 COC1=CC=C(C=C1)S(=O)(=O)N2CCC(CC2)NCC(COC3=CC=CC4=C3C5=CC=CC=C5N4)O
CHEMBL567843 adrb1_human Human No 6.0 EC50 = 1004 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
395 7 3 3 4.9 CC(C)C1=CC=C(C=C1)CC(C)(C)NCC(C2=CC(=C(C(=C2)Cl)N)Cl)O
CHEMBL567843 adrb1_human Human No 6.0 EC50 = 1004 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
395 7 3 3 4.9 CC(C)C1=CC=C(C=C1)CC(C)(C)NCC(C2=CC(=C(C(=C2)Cl)N)Cl)O
CHEMBL600401 adrb1_human Human No 7.0 EC50 = 101 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
374 6 4 6 1.9 CC(C)(CC1=CC=C(C=C1)F)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL600401 adrb1_human Human No 7.0 EC50 = 101 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
374 6 4 6 1.9 CC(C)(CC1=CC=C(C=C1)F)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL100057 adrb1_human Human No 6.0 EC50 = 1010 Funct
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
605 12 5 10 2.8 C1CN(CCC1CNCC(COC2=CC=C(C=C2)O)O)S(=O)(=O)C3=CC=C(C=C3)NC(=O)NCC4=C(C=CC(=C4)F)F
CHEMBL101485 adrb1_human Human No 6.0 EC50 = 1015 Funct
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
561 11 5 8 2.9 C1CCC(CC1)NC(=O)NC2=CC=C(C=C2)S(=O)(=O)N3CCC(CC3)CNCC(COC4=CC=C(C=C4)O)O
CHEMBL600616 adrb1_human Human No 7.0 EC50 = 103.4 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
435 6 4 5 2.5 CC(C)(CC1=CC=C(C=C1)Br)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL600616 adrb1_human Human No 7.0 EC50 = 103.4 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
435 6 4 5 2.5 CC(C)(CC1=CC=C(C=C1)Br)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL71348 adrb1_human Human No 5.0 EC50 = 10300 Funct
Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells
437 9 3 8 1.9 COC1=CC=C(C=C1)S(=O)(=O)N2CCC(CC2)NCC(COC3=CC=C(C=C3)O)O
CHEMBL322973 adrb1_human Human No 7.0 EC50 = 109 Funct
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
537 12 5 7 3.9 C1CN(CCC1NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)C(=O)NCC4=CC=C(C=C4)F
CHEMBL430662 adrb1_human Human No 5.0 EC50 = 10900 Funct
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
563 15 5 8 3.4 CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCC(CC2)CNCC(COC3=CC=C(C=C3)O)O
CHEMBL273097 adrb1_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
397 8 3 5 1.1 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=NC=C(C=C3)C(=O)O)O
CHEMBL568667 adrb1_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
457 10 6 7 0.3 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCN)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL459645 adrb1_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
469 12 4 6 2.7 CCCOC1=C(C=CC(=C1)C2=CC=C(C=C2)NCCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL273097 adrb1_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
397 8 3 5 1.1 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=NC=C(C=C3)C(=O)O)O
CHEMBL568667 adrb1_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
457 10 6 7 0.3 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCN)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL459645 adrb1_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
469 12 4 6 2.7 CCCOC1=C(C=CC(=C1)C2=CC=C(C=C2)NCCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL563872 adrb1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
427 11 3 6 3.3 C1=CC=C(C=C1)OCC(CNCCC2=CC=C(C=C2)NS(=O)(=O)C3=CC=CC=C3)O
CHEMBL1258824 adrb1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
519 9 4 8 3.4 C1CN(CCC1NCC(COC2=CC=CC(=C2)NC(=O)N)O)C3=C4C(=CSC4=NC=N3)C5=CC=CC=C5
CHEMBL557253 adrb1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
567 11 4 7 4.9 CC(C(C1=CC=C(C=C1)O)O)NCCC2=CC=C(C=C2)C3=CC(=C(C=C3)C(=O)NS(=O)(=O)C)OC4CCCCC4
CHEMBL452034 adrb1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
484 12 3 6 3.1 CC(C)COC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL563872 adrb1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
427 11 3 6 3.3 C1=CC=C(C=C1)OCC(CNCCC2=CC=C(C=C2)NS(=O)(=O)C3=CC=CC=C3)O
CHEMBL1258824 adrb1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
519 9 4 8 3.4 C1CN(CCC1NCC(COC2=CC=CC(=C2)NC(=O)N)O)C3=C4C(=CSC4=NC=N3)C5=CC=CC=C5
CHEMBL557253 adrb1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
567 11 4 7 4.9 CC(C(C1=CC=C(C=C1)O)O)NCCC2=CC=C(C=C2)C3=CC(=C(C=C3)C(=O)NS(=O)(=O)C)OC4CCCCC4
CHEMBL452034 adrb1_human Human No 7.0 EC50 = 110 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
484 12 3 6 3.1 CC(C)COC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL164378 adrb1_human Human No 5.9 EC50 = 1170 Funct
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
551 10 5 11 2.1 CS(=O)(=O)NC1=C(C=CC(=C1)OC(CNC2CCN(CC2)C3=CC=C(C=C3)CC4C(=O)NC(=O)S4)O)O
CHEMBL459646 adrb1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
450 11 4 7 1.4 CC(C)CC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CN=C(C=C3)N)O)C(=O)O
CHEMBL488431 adrb1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
410 8 3 4 2.5 CC(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL459646 adrb1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
450 11 4 7 1.4 CC(C)CC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CN=C(C=C3)N)O)C(=O)O
CHEMBL488431 adrb1_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
410 8 3 4 2.5 CC(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL68766 adrb1_human Human No 7.9 EC50 = 12 Funct
Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells
612 14 6 10 2.0 CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCC(CC2)NCC(C3=CC(=C(C=C3)O)NS(=O)(=O)C)O
CHEMBL183744 adrb1_human Human No 7.9 EC50 = 12 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
466 12 5 6 2.7 COC1=CC=CC=C1NC(=O)NC2=CC=C(C=C2)CC(CO)NCC(COC3=CC=CC=C3)O
CHEMBL247518 adrb1_human Human No 7.9 EC50 = 12.0 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
432 9 4 7 1.7 CC(CNC1=CC=C(C=C1)C2=CSC(=N2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL247518 adrb1_human Human No 7.9 EC50 = 12.0 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
432 9 4 7 1.7 CC(CNC1=CC=C(C=C1)C2=CSC(=N2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL246908 adrb1_human Human No 7.9 EC50 = 12.6 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
416 9 4 7 1.0 CC(CNC1=CC=C(C=C1)C2=NC(=CO2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL3298692 adrb1_human Human No 7.9 EC50 = 12.6 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
575 14 6 8 3.9 CC(C)(C)OC(=O)NCCOC1=CC=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O
CHEMBL1256786 adrb1_human Human Yes 7.9 EC50 = 12.6 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
344 8 4 5 1.8 CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
CHEMBL3298831 adrb1_human Human No 7.9 EC50 = 12.6 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
545 12 5 8 2.8 C1COCCN1CCOC2=CC=C(C=C2)NC3=CC=C(C=C3)CCNCC(C4=C5C=CC(=O)NC5=C(C=C4)O)O
CHEMBL1256786 adrb1_human Human Yes 7.9 EC50 = 12.6 Funct
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
344 8 4 5 1.8 CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
CHEMBL246908 adrb1_human Human No 7.9 EC50 = 12.6 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
416 9 4 7 1.0 CC(CNC1=CC=C(C=C1)C2=NC(=CO2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL3298692 adrb1_human Human No 7.9 EC50 = 12.6 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
575 14 6 8 3.9 CC(C)(C)OC(=O)NCCOC1=CC=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O
CHEMBL1256786 adrb1_human Human Yes 7.9 EC50 = 12.6 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
344 8 4 5 1.8 CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
CHEMBL3298831 adrb1_human Human No 7.9 EC50 = 12.6 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
545 12 5 8 2.8 C1COCCN1CCOC2=CC=C(C=C2)NC3=CC=C(C=C3)CCNCC(C4=C5C=CC(=O)NC5=C(C=C4)O)O
CHEMBL1256786 adrb1_human Human Yes 7.9 EC50 = 12.6 Funct
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
344 8 4 5 1.8 CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
CHEMBL452033 adrb1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
470 12 3 6 2.7 CCCOC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL452033 adrb1_human Human No 6.9 EC50 = 120 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
470 12 3 6 2.7 CCCOC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL182708 adrb1_human Human No 6.9 EC50 = 120 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
508 10 4 6 3.5 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C)NCC(C3=CC(=CC=C3)NC(=O)C4=CC=CC=C4)O
CHEMBL274807 adrb1_human Human No 5.9 EC50 = 1200 Funct
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
449 11 4 7 3.2 C1CCC(CC1)S(=O)(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL286574 adrb1_human Human No 5.9 EC50 = 1200 Funct
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
449 8 5 8 0.5 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNC2CCN(CC2)C3=CC=C(C=C3)C(=O)N)O)O
CHEMBL1814279 adrb1_human Human No 6.9 EC50 = 125.9 Funct
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
532 19 7 8 0.2 C1=CC(=CC(=C1)NC(=O)NCC(=O)O)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O
CHEMBL1814279 adrb1_human Human No 6.9 EC50 = 125.9 Funct
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
532 19 7 8 0.2 C1=CC(=CC(=C1)NC(=O)NCC(=O)O)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O
CHEMBL208352 adrb1_human Human No 5.9 EC50 = 1258.9 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
425 10 3 5 4.4 COC(=O)C1=CC=CC(=C1)C2=CC(=CC=C2)NCCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL245873 adrb1_human Human No 5.9 EC50 = 1258.9 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
431 9 4 6 2.0 CC(CNC1=CC=CC(=C1)C2=C(C=CS2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL208352 adrb1_human Human No 5.9 EC50 = 1258.9 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
425 10 3 5 4.4 COC(=O)C1=CC=CC(=C1)C2=CC(=CC=C2)NCCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL245873 adrb1_human Human No 5.9 EC50 = 1258.9 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
431 9 4 6 2.0 CC(CNC1=CC=CC(=C1)C2=C(C=CS2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL488430 adrb1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
410 8 3 4 2.5 CC(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL2260985 adrb1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
559 11 5 9 2.5 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CC(=C4)N)O
CHEMBL488430 adrb1_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
410 8 3 4 2.5 CC(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL181440 adrb1_human Human No 7.9 EC50 = 13 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
544 11 4 8 3.2 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CC=C4)O
CHEMBL467301 adrb1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
485 13 3 5 3.3 C1=CC=C(C=C1)CN2C=C(N=C2)CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=CC=C4)O
CHEMBL490222 adrb1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
531 11 4 6 3.4 C1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)OC3=CC=CC(=C3)CCNCC(C4=CC(=CC=C4)Cl)O)C(=O)O
CHEMBL550871 adrb1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
527 11 4 7 3.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNC(C)C(C3=CC(=CC=C3)O)O)C(=O)NS(=O)(=O)C
CHEMBL453322 adrb1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
448 11 3 5 3.2 CC(C)COC1=C(C=CC(=C1)C2=CC=C(C=C2)CC(C)NCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL488223 adrb1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
436 10 4 7 0.8 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CN=C(C=C3)N)O)C(=O)O
CHEMBL473495 adrb1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
436 10 4 7 1.0 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=C(C=CN=C3)N)O)C(=O)O
CHEMBL467301 adrb1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
485 13 3 5 3.3 C1=CC=C(C=C1)CN2C=C(N=C2)CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=CC=C4)O
CHEMBL490222 adrb1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
531 11 4 6 3.4 C1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)OC3=CC=CC(=C3)CCNCC(C4=CC(=CC=C4)Cl)O)C(=O)O
CHEMBL550871 adrb1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
527 11 4 7 3.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNC(C)C(C3=CC(=CC=C3)O)O)C(=O)NS(=O)(=O)C
CHEMBL453322 adrb1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
448 11 3 5 3.2 CC(C)COC1=C(C=CC(=C1)C2=CC=C(C=C2)CC(C)NCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL488223 adrb1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
436 10 4 7 0.8 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CN=C(C=C3)N)O)C(=O)O
CHEMBL473495 adrb1_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
436 10 4 7 1.0 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=C(C=CN=C3)N)O)C(=O)O
CHEMBL286818 adrb1_human Human No 6.9 EC50 = 130 Funct
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
359 7 3 3 3.8 CC(CC1=CNC2=C1C=CC=C2OC)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL466704 adrb1_human Human No 5.9 EC50 = 1300 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
445 11 4 5 2.6 C1=CC=NC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=CC4=C3C=CN4)O
CHEMBL466704 adrb1_human Human No 5.9 EC50 = 1300 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
445 11 4 5 2.6 C1=CC=NC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=CC4=C3C=CN4)O
CHEMBL24350 adrb1_human Human Yes 7.9 EC50 = 14 Funct
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
403 9 4 5 1.1 CC(CC1=CNC2=C1C=CC=C2OCC(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL299175 adrb1_human Human Yes 7.9 EC50 = 14 Funct
Compound was evaluated for its inhibitory activity against human Beta-1 adrenergic receptorCompound was evaluated for its inhibitory activity against human Beta-1 adrenergic receptor
345 5 3 6 2.5 COC1=CC(=CC(=C1OC)OC)CC2C3=CC(=C(C=C3CCN2)O)O
CHEMBL467298 adrb1_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
535 13 3 5 4.7 C1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2CC(=O)NC4=CC=C(C=C4)CCNCC(COC5=CC=CC=C5)O
CHEMBL521611 adrb1_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
430 9 3 6 2.1 C1=CC(=CC(=C1)OC2=CC(=C(C=C2)F)C(=O)O)CCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL463182 adrb1_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
439 7 3 6 1.7 C1CC2=C(CC1NCC(C3=CN=C(C=C3)Cl)O)C=C(C=C2)OC4=CC=CC(=C4)C(=O)O
CHEMBL467298 adrb1_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
535 13 3 5 4.7 C1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2CC(=O)NC4=CC=C(C=C4)CCNCC(COC5=CC=CC=C5)O
CHEMBL521611 adrb1_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
430 9 3 6 2.1 C1=CC(=CC(=C1)OC2=CC(=C(C=C2)F)C(=O)O)CCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL463182 adrb1_human Human No 6.9 EC50 = 140 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
439 7 3 6 1.7 C1CC2=C(CC1NCC(C3=CN=C(C=C3)Cl)O)C=C(C=C2)OC4=CC=CC(=C4)C(=O)O
CHEMBL282039 adrb1_human Human No 6.9 EC50 = 140 Funct
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
329 6 3 2 3.8 CC(CC1=CNC2=CC=CC=C21)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL453575 adrb1_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
468 11 3 5 3.4 CC(C)CC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL453575 adrb1_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
468 11 3 5 3.4 CC(C)CC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL182127 adrb1_human Human No 7.8 EC50 = 15 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
442 11 5 5 3.0 C1CCC(CC1)NC(=O)NC2=CC=C(C=C2)CC(CO)NCC(COC3=CC=CC=C3)O
CHEMBL561291 adrb1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
471 11 4 5 4.5 C1=CC=C2C=C(C=CC2=C1)CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL561743 adrb1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
606 13 5 10 2.5 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NS(=O)(=O)C)O)C(=O)NS(=O)(=O)C
CHEMBL487682 adrb1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
434 10 4 6 1.6 CC(C)CC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CN=C(C=C3)N)O)C(=O)O
CHEMBL512147 adrb1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
529 12 5 9 0.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NS(=O)(=O)C)O)C(=O)O
CHEMBL473702 adrb1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
434 10 4 6 1.9 CC(C)CC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=C(C=CN=C3)N)O)C(=O)O
CHEMBL561291 adrb1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
471 11 4 5 4.5 C1=CC=C2C=C(C=CC2=C1)CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL561743 adrb1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
606 13 5 10 2.5 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NS(=O)(=O)C)O)C(=O)NS(=O)(=O)C
CHEMBL487682 adrb1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
434 10 4 6 1.6 CC(C)CC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CN=C(C=C3)N)O)C(=O)O
CHEMBL512147 adrb1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
529 12 5 9 0.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NS(=O)(=O)C)O)C(=O)O
CHEMBL473702 adrb1_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
434 10 4 6 1.9 CC(C)CC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=C(C=CN=C3)N)O)C(=O)O
CHEMBL498305 adrb1_human Human Yes 5.8 EC50 = 1500 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
376 7 3 5 1.0 C1CC2=C(CC1NCC(C3=CC(=CC=C3)Cl)O)C=C(C=C2)OCC(=O)O
CHEMBL498305 adrb1_human Human Yes 5.8 EC50 = 1500 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
376 7 3 5 1.0 C1CC2=C(CC1NCC(C3=CC(=CC=C3)Cl)O)C=C(C=C2)OCC(=O)O
CHEMBL161949 adrb1_human Human No 5.8 EC50 = 1530 Funct
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
509 8 4 8 2.9 C1CN(CCC1NCC(O)OC2=CC=CC3=C2C=CC(=O)N3)C4=CC=C(C=C4)CC5C(=O)NC(=O)S5
CHEMBL1807873 adrb1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
500 13 5 7 3.0 C1=CC(=C(C(=C1)Cl)Cl)CCNCCOCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL393469 adrb1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
416 9 4 7 1.0 CC(CNC1=CC=CC(=C1)C2=NC(=CO2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL1807873 adrb1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
500 13 5 7 3.0 C1=CC(=C(C(=C1)Cl)Cl)CCNCCOCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL393469 adrb1_human Human No 6.8 EC50 = 158.5 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
416 9 4 7 1.0 CC(CNC1=CC=CC(=C1)C2=NC(=CO2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL498531 adrb1_human Human No 6.8 EC50 = 160 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
452 7 3 5 2.8 C1CC(CC2=C(C1)C=CC(=C2)OC3=CC=CC(=C3)C(=O)O)NCC(C4=CC(=CC=C4)Cl)O
CHEMBL498531 adrb1_human Human No 6.8 EC50 = 160 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
452 7 3 5 2.8 C1CC(CC2=C(C1)C=CC(=C2)OC3=CC=CC(=C3)C(=O)O)NCC(C4=CC(=CC=C4)Cl)O
CHEMBL182770 adrb1_human Human No 6.8 EC50 = 160 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
472 11 4 6 4.2 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C)NCC(C3=CC(=CC=C3)NCC=C(C)C)O
CHEMBL1682217 adrb1_rat Rat No 5.8 EC50 = 1600 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
541 9 6 5 3.4 C1=CC(=CC(=C1)NC(=O)NCC2=C(C=CC=C2Cl)Cl)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O
CHEMBL417613 adrb1_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
443 11 4 7 3.0 C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL417613 adrb1_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
443 11 4 7 3.0 C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL1682217 adrb1_rat Rat No 5.8 EC50 = 1600 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
541 9 6 5 3.4 C1=CC(=CC(=C1)NC(=O)NCC2=C(C=CC=C2Cl)Cl)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O
CHEMBL417613 adrb1_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
443 11 4 7 3.0 C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL417613 adrb1_human Human No 5.8 EC50 = 1600 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
443 11 4 7 3.0 C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL302803 adrb1_human Human No 5.8 EC50 = 1600 Funct
Agonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cellsAgonistic activity against cloned human beta1-AR (beta-1-adrenergic receptor) in CHO cells
421 10 3 7 2.2 CCCCOC1=CC=C(C=C1)S(=O)(=O)N2CC(C2)NCC(C3=CC=C(C=C3)O)O
CHEMBL32888 adrb1_human Human No 5.8 EC50 = 1600 Funct
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
494 11 5 10 -1.4 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNC2CCN(CC2)C3=CC=C(C=C3)COCC(=O)O)O)O
CHEMBL108061 adrb1_human Human No 6.8 EC50 = 164 Funct
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
485 12 4 6 3.2 CCN(CC)C(=O)N1CCC(CC1)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL512099 adrb1_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
525 12 2 5 3.9 C1CC2=C(C=CC(=C2)CCNCC(COC3=CC=CC=C3)O)N(C1)C(=O)CC4=NC=CN4CC5=CC=CC=C5
CHEMBL270964 adrb1_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
419 10 4 5 2.8 CC(C)NC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL270964 adrb1_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
419 10 4 5 2.8 CC(C)NC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL512099 adrb1_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
525 12 2 5 3.9 C1CC2=C(C=CC(=C2)CCNCC(COC3=CC=CC=C3)O)N(C1)C(=O)CC4=NC=CN4CC5=CC=CC=C5
CHEMBL270964 adrb1_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
419 10 4 5 2.8 CC(C)NC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL270964 adrb1_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
419 10 4 5 2.8 CC(C)NC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL425161 adrb1_human Human No 6.8 EC50 = 170 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
458 11 4 6 3.6 CC=CCNC1=CC=CC(=C1)C(CNC(C)CC2=CNC3=C2C=CC=C3OS(=O)(=O)C)O
CHEMBL552089 adrb1_human Human No 5.8 EC50 = 1700 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
472 11 4 6 3.5 C1=CC=C2C(=C1)C=CC(=N2)CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL284782 adrb1_human Human No 5.8 EC50 = 1700 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
364 9 3 5 0.9 CC(CC1=CC=C(C=C1)OCC(=O)O)NCC(C2=CC(=CC=C2)Cl)O
CHEMBL552089 adrb1_human Human No 5.8 EC50 = 1700 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
472 11 4 6 3.5 C1=CC=C2C(=C1)C=CC(=N2)CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL284782 adrb1_human Human No 5.8 EC50 = 1700 Funct
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
364 9 3 5 0.9 CC(CC1=CC=C(C=C1)OCC(=O)O)NCC(C2=CC(=CC=C2)Cl)O
CHEMBL603274 adrb1_human Human No 6.8 EC50 = 171 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
391 6 4 5 2.4 CC(C)(CC1=CC=C(C=C1)Cl)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL603274 adrb1_human Human No 6.8 EC50 = 171 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
391 6 4 5 2.4 CC(C)(CC1=CC=C(C=C1)Cl)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL458923 adrb1_human Human No 6.8 EC50 = 173 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
495 10 4 6 3.3 CCCNC1=CC(=CC(=C1)C(=O)O)OC2=CC3=C(CCC(C3)NCC(C4=CC(=CC=C4)Cl)O)C=C2
CHEMBL458923 adrb1_human Human No 6.8 EC50 = 173 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
495 10 4 6 3.3 CCCNC1=CC(=CC(=C1)C(=O)O)OC2=CC3=C(CCC(C3)NCC(C4=CC(=CC=C4)Cl)O)C=C2
CHEMBL299175 b0fl73_cavpo Guinea pig Yes 6.8 EC50 = 173.8 Funct
Inhibitory activity against Beta-1 adrenergic receptor in guinea pig atria after treatment with the compoundInhibitory activity against Beta-1 adrenergic receptor in guinea pig atria after treatment with the compound
345 5 3 6 2.5 COC1=CC(=CC(=C1OC)OC)CC2C3=CC(=C(C=C3CCN2)O)O
CHEMBL10494 b0fl73_cavpo Guinea pig Yes 6.8 EC50 = 175 Funct
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
273 6 4 6 1.2 CC(C)(C)NCC(COC1=C(C=C(C(=C1)O)O)F)O
CHEMBL270889 adrb1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
426 9 3 5 2.1 COC1=C(C=CC(=C1)C(=O)O)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL565770 adrb1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
499 11 7 7 -0.3 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCN=C(N)N)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL184407 adrb1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
550 11 4 9 3.2 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL270889 adrb1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
426 9 3 5 2.1 COC1=C(C=CC(=C1)C(=O)O)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL565770 adrb1_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
499 11 7 7 -0.3 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCN=C(N)N)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL466713 adrb1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
406 11 3 6 1.5 C1=CC=NC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CN=CC=C3)O
CHEMBL467083 adrb1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
485 13 3 5 3.3 C1=CC=C(C=C1)CN2C=CN=C2CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=CC=C4)O
CHEMBL551831 adrb1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
497 12 4 5 4.9 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL459863 adrb1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
468 12 3 5 3.3 CCCOC1=C(C=CC(=C1)C2=CC=C(C=C2)CCCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL188196 adrb1_human Human No 6.8 EC50 = 180 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
530 12 5 9 1.0 CC(CC1=CNC2=C1C=CC=C2OCC(=O)O)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL466713 adrb1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
406 11 3 6 1.5 C1=CC=NC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CN=CC=C3)O
CHEMBL467083 adrb1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
485 13 3 5 3.3 C1=CC=C(C=C1)CN2C=CN=C2CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=CC=C4)O
CHEMBL551831 adrb1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
497 12 4 5 4.9 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL459863 adrb1_human Human No 6.8 EC50 = 180 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
468 12 3 5 3.3 CCCOC1=C(C=CC(=C1)C2=CC=C(C=C2)CCCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL188196 adrb1_human Human No 6.8 EC50 = 180 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
530 12 5 9 1.0 CC(CC1=CNC2=C1C=CC=C2OCC(=O)O)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL75604 adrb1_human Human No 5.8 EC50 = 1800 Funct
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
629 12 6 7 6.1 CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)C3=CC=C(C=C3)CC4C5=CC(=C(C=C5CCN4)O)O
CHEMBL101630 adrb1_human Human No 5.7 EC50 = 1860 Funct
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
577 13 6 10 0.1 CC(C)CC(C(=O)O)NC(=O)C1=CC=C(C=C1)N2CCC(CC2)CNCC(C3=CC(=C(C=C3)O)NS(=O)(=O)C)O
CHEMBL566352 adrb1_human Human No 5.7 EC50 = 1869 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
383 7 4 7 3.4 CC(C)(CC1=CC(=CC=C1)C(F)(F)F)NCC(C2=CC(=C(C=C2)O)CO)O
CHEMBL566352 adrb1_human Human No 5.7 EC50 = 1869 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
383 7 4 7 3.4 CC(C)(CC1=CC(=CC=C1)C(F)(F)F)NCC(C2=CC(=C(C=C2)O)CO)O
CHEMBL323258 adrb1_human Human No 6.7 EC50 = 187 Funct
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
539 14 5 6 5.2 C1CCC(C1)CCCNC(=O)N2CCC(CC2)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL185703 adrb1_human Human No 7.7 EC50 = 19 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
557 12 4 8 3.2 CC(CC1=CNC2=C1C=CC=C2OCC(=O)N(C)C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL188196 adrb1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
530 12 5 9 1.0 CC(CC1=CNC2=C1C=CC=C2OCC(=O)O)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL2260986 adrb1_human Human No 7.7 EC50 = 19 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
544 11 4 8 3.2 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C)NCC(C3=CC=C(C=C3)S(=O)(=O)NC4=CC=CC=C4)O
CHEMBL185703 adrb1_human Human No 7.7 EC50 = 19 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
557 12 4 8 3.2 CC(CC1=CNC2=C1C=CC=C2OCC(=O)N(C)C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL74085 adrb1_human Human No 7.7 EC50 = 19 Funct
Percent adenylyl cyclase activation at 10000 nM of compound concentrationPercent adenylyl cyclase activation at 10000 nM of compound concentration
553 11 6 7 4.5 CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CC3C4=CC(=C(C=C4CCN3)O)O
CHEMBL247520 adrb1_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
415 9 4 6 1.4 CC(CNC1=CC=C(C=C1)C2=C(C=CO2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL430390 adrb1_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
432 9 4 7 1.7 CC(CNC1=CC=C(C=C1)C2=NC(=CS2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL348269 adrb1_human Human No 7.7 EC50 = 20.0 Funct
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
502 12 4 6 4.7 CC1=CC=C(C=C1)S(=O)(=O)NCCC2=CC=C(C=C2)NCC(C)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL247520 adrb1_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
415 9 4 6 1.4 CC(CNC1=CC=C(C=C1)C2=C(C=CO2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL430390 adrb1_human Human No 7.7 EC50 = 20.0 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
432 9 4 7 1.7 CC(CNC1=CC=C(C=C1)C2=NC(=CS2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL467102 adrb1_human Human No 6.7 EC50 = 190 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
563 13 3 5 4.0 C1=CC=C(C=C1)OCC(CNCCC2=CC=C(C=C2)NC(=O)CC3=NC=CN3CC4=CC=C(C=C4)Br)O
CHEMBL524145 adrb1_human Human No 6.7 EC50 = 190 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
531 11 4 6 2.8 C1=CC=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(=O)O)OC3=CC=CC(=C3)CCNCC(C4=CC(=CC=C4)Cl)O
CHEMBL563810 adrb1_human Human No 6.7 EC50 = 190 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
455 11 4 5 3.8 C1=CC(=CC=C1CCNCC(COC2=CC=C(C=C2)O)O)NC(=O)CC3=CC=C(C=C3)Cl
CHEMBL507506 adrb1_human Human No 6.7 EC50 = 190 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
435 11 3 6 1.7 CCCOC1=C(C=CC(=C1)C2=CC=C(C=C2)CC(C)NCC(C3=CN=CC=C3)O)C(=O)O
CHEMBL467102 adrb1_human Human No 6.7 EC50 = 190 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
563 13 3 5 4.0 C1=CC=C(C=C1)OCC(CNCCC2=CC=C(C=C2)NC(=O)CC3=NC=CN3CC4=CC=C(C=C4)Br)O
CHEMBL524145 adrb1_human Human No 6.7 EC50 = 190 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
531 11 4 6 2.8 C1=CC=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(=O)O)OC3=CC=CC(=C3)CCNCC(C4=CC(=CC=C4)Cl)O
CHEMBL563810 adrb1_human Human No 6.7 EC50 = 190 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
455 11 4 5 3.8 C1=CC(=CC=C1CCNCC(COC2=CC=C(C=C2)O)O)NC(=O)CC3=CC=C(C=C3)Cl
CHEMBL507506 adrb1_human Human No 6.7 EC50 = 190 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
435 11 3 6 1.7 CCCOC1=C(C=CC(=C1)C2=CC=C(C=C2)CC(C)NCC(C3=CN=CC=C3)O)C(=O)O
CHEMBL22375 adrb1_human Human Yes 5.7 EC50 = 1900 Funct
Agonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclaseAgonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclase
592 14 3 9 4.9 C1CCC(C1)CCCN2C(=O)N(N=N2)C3=CC=C(C=C3)S(=O)(=O)NC4=CC=C(C=C4)CCNCC(C5=CN=CC=C5)O
CHEMBL1807874 adrb1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
446 13 4 7 2.2 CN(CCC1=CC=CC=C1)CCOCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1814270 adrb1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
514 17 5 7 2.7 C1C(=O)N(C(=O)N1)C2=CC=CC=C2CCCCOCCCCCCNCC(C3=CC(=C(C=C3)O)CO)O
CHEMBL1807874 adrb1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
446 13 4 7 2.2 CN(CCC1=CC=CC=C1)CCOCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1814270 adrb1_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
514 17 5 7 2.7 C1C(=O)N(C(=O)N1)C2=CC=CC=C2CCCCOCCCCCCNCC(C3=CC(=C(C=C3)O)CO)O
CHEMBL307647 adrb1_human Human No 8.7 EC50 = 2 Funct
Percent adenylyl cyclase activation at 10000 nM of compound concentrationPercent adenylyl cyclase activation at 10000 nM of compound concentration
527 3 2 5 3.3 COC1=C(C=C(C=C1I)CC2C3=C(CCN2)N=C(S3)N)I
CHEMBL183307 adrb1_human Human No 8.7 EC50 = 2.2 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
466 12 5 6 2.7 COC1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)CC(CO)NCC(COC3=CC=CC=C3)O
CHEMBL207802 adrb1_human Human Yes 8.6 EC50 = 2.3 Funct
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
485 15 5 8 1.5 C1CC1COCCOC2=CC(=C(C=C2)OCC(CNCCNC(=O)NC3=CC=C(C=C3)O)O)C#N
CHEMBL2348218 adrb1_human Human No 8.6 EC50 = 2.3 Funct
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
528 16 5 8 3.2 C1=CC(=CC=C1CCOCCOC2=CC=C(C=C2)OCC(CNCCNC(=O)NC3=CC=C(C=C3)O)O)F
CHEMBL3298326 adrb1_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
551 11 6 7 3.7 COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)C5=CC=C(C=C5)CN
CHEMBL3298324 adrb1_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
551 11 6 7 3.7 COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)C5=CC=CC=C5CN
CHEMBL3298326 adrb1_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
551 11 6 7 3.7 COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)C5=CC=C(C=C5)CN
CHEMBL3298324 adrb1_human Human No 8.6 EC50 = 2.5 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
551 11 6 7 3.7 COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)C5=CC=CC=C5CN
CHEMBL408145 adrb1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
414 8 3 5 2.2 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=C(C=C(C=C3)C(=O)O)F)O
CHEMBL186135 adrb1_human Human No 7.7 EC50 = 20 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
648 18 4 9 6.7 CCCCCCCCS(=O)(=O)OC1=CC=CC2=C1NC=C2CC(C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL408145 adrb1_human Human No 7.7 EC50 = 20 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
414 8 3 5 2.2 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=C(C=C(C=C3)C(=O)O)F)O
CHEMBL183129 adrb1_human Human No 7.7 EC50 = 20 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
436 11 5 5 2.7 C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)CC(CO)NCC(COC3=CC=CC=C3)O
CHEMBL186135 adrb1_human Human No 7.7 EC50 = 20 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
648 18 4 9 6.7 CCCCCCCCS(=O)(=O)OC1=CC=CC2=C1NC=C2CC(C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL271765 adrb1_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
402 8 3 5 2.1 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC=C(S3)C(=O)O)O
CHEMBL516002 adrb1_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
423 6 3 5 1.8 C1CC2=C(CC1NCC(C3=CN=C(C=C3)Cl)O)C=C(C=C2)C4=CC=C(C=C4)C(=O)O
CHEMBL600007 adrb1_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
400 8 4 6 2.1 CCOC1=CC=C(C=C1)CC(C)(C)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL491726 adrb1_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
513 11 4 8 2.6 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=C(C=CN=C3)N)O)C(=O)NS(=O)(=O)C
CHEMBL271765 adrb1_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
402 8 3 5 2.1 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC=C(S3)C(=O)O)O
CHEMBL516002 adrb1_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
423 6 3 5 1.8 C1CC2=C(CC1NCC(C3=CN=C(C=C3)Cl)O)C=C(C=C2)C4=CC=C(C=C4)C(=O)O
CHEMBL600007 adrb1_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
400 8 4 6 2.1 CCOC1=CC=C(C=C1)CC(C)(C)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL491726 adrb1_human Human No 6.7 EC50 = 200 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
513 11 4 8 2.6 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=C(C=CN=C3)N)O)C(=O)NS(=O)(=O)C
CHEMBL35500 adrb1_human Human No 5.7 EC50 = 2000 Funct
In vitro activity to increase cAMP levels in Chinese hamster ovary (CHO) cells expressing the cloned human beta 1 Adrenergic receptorIn vitro activity to increase cAMP levels in Chinese hamster ovary (CHO) cells expressing the cloned human beta 1 Adrenergic receptor
599 14 5 12 -0.7 CCCCN(C1=CC=C(C=C1)N2CCC(CC2)NCC(C3=CC(=C(C=C3)O)NS(=O)(=O)C)O)S(=O)(=O)CC(=O)O
CHEMBL165893 adrb1_human Human No 5.7 EC50 = 2020 Funct
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
456 9 3 7 3.4 C1CN(CCC1NCC(COC2=CC=CC=C2)O)C3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL458541 adrb1_human Human No 5.7 EC50 = 2035 Funct
Agonist activity at adrenergic beta-1 receptorAgonist activity at adrenergic beta-1 receptor
354 8 2 4 3.7 CC(C)NCC(COC1=CC2=C(C=C1)N(CCC2)CC3=CC=CC=C3)O
CHEMBL458541 adrb1_human Human No 5.7 EC50 = 2035 Funct
Agonist activity at adrenergic beta-1 receptorAgonist activity at adrenergic beta-1 receptor
354 8 2 4 3.7 CC(C)NCC(COC1=CC2=C(C=C1)N(CCC2)CC3=CC=CC=C3)O
CHEMBL100124 adrb1_human Human No 5.7 EC50 = 2050 Funct
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
603 14 5 9 3.1 C1CN(CCC1CNCC(COC2=CC=C(C=C2)O)O)S(=O)(=O)C3=CC=C(C=C3)NC(=O)NCCCC4=CC=CS4
CHEMBL605372 adrb1_human Human No 6.7 EC50 = 207 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
399 7 4 5 2.9 CC(C)C1=CC=C(C=C1)CC(C)(C)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL601858 adrb1_human Human No 6.7 EC50 = 207 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
433 7 4 5 3.4 CC(C)(CC1=CC=C(C=C1)C2=CC=CC=C2)NCC(C3=CC(=CC4=C3OCC(=O)N4)O)O
CHEMBL605372 adrb1_human Human No 6.7 EC50 = 207 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
399 7 4 5 2.9 CC(C)C1=CC=C(C=C1)CC(C)(C)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL601858 adrb1_human Human No 6.7 EC50 = 207 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
433 7 4 5 3.4 CC(C)(CC1=CC=C(C=C1)C2=CC=CC=C2)NCC(C3=CC(=CC4=C3OCC(=O)N4)O)O
CHEMBL185836 adrb1_human Human No 7.7 EC50 = 21 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
456 9 4 6 3.7 CC(CC1=CNC2=CC=CC=C21)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL162711 adrb1_human Human No 7.7 EC50 = 21 Funct
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
510 9 3 8 2.0 C1CN(CCC1NCC(COC2=CC=CC3=NC(=O)N=C32)O)C4=CC=C(C=C4)CC5C(=O)NC(=O)S5
CHEMBL417613 adrb1_human Human No 6.7 EC50 = 210 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
443 11 4 7 3.0 C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL460256 adrb1_human Human No 6.7 EC50 = 210 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
436 12 3 6 2.0 CCCOC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL417613 adrb1_human Human No 6.7 EC50 = 210 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
443 11 4 7 3.0 C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL460256 adrb1_human Human No 6.7 EC50 = 210 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
436 12 3 6 2.0 CCCOC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL602258 adrb1_human Human No 6.7 EC50 = 215 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
384 7 4 5 2.6 CCC1=CC=C(C=C1)CC(C)(C)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL602258 adrb1_human Human No 6.7 EC50 = 215 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
384 7 4 5 2.6 CCC1=CC=C(C=C1)CC(C)(C)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL507003 adrb1_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
375 8 3 4 1.9 CC(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O)NCC(C3=CC=CC=C3)O
CHEMBL189081 adrb1_human Human No 7.7 EC50 = 22 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
613 12 4 10 3.7 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C3=CN=CC=C3)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL2260988 adrb1_human Human No 7.7 EC50 = 22 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
576 12 3 7 5.2 CC(CC1=CN(C2=C1C=CC=C2OC)CC3=CC=CC=C3)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL507003 adrb1_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
375 8 3 4 1.9 CC(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O)NCC(C3=CC=CC=C3)O
CHEMBL189081 adrb1_human Human No 7.7 EC50 = 22 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
613 12 4 10 3.7 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C3=CN=CC=C3)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL2348217 adrb1_human Human No 7.6 EC50 = 22.9 Funct
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
434 14 5 7 1.4 CCOCCOC1=CC=C(C=C1)OCC(CNCCNC(=O)NC2=CC=C(C=C2)O)O
CHEMBL460574 b0fl73_cavpo Guinea pig Yes 5.7 EC50 = 2200 Funct
Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium.
211 4 4 4 -0.6 CC(C)NCC(C1=CC(=C(C=C1)O)O)O
CHEMBL1346 adrb1_rat Rat Yes 5.6 EC50 = 2310 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
427 7 1 3 4.6 C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5
CHEMBL1346 adrb1_rat Rat Yes 5.6 EC50 = 2310 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
427 7 1 3 4.6 C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5
CHEMBL1788251 b0fl73_cavpo Guinea pig No 6.6 EC50 = 239.9 Funct
Inhibitory activity against Beta-1 adrenergic receptor in guinea pig atriaInhibitory activity against Beta-1 adrenergic receptor in guinea pig atria
363 5 3 7 2.6 COC1=CC(=CC(=C1OC)OC)CC2C3=C(C(=C(C=C3CCN2)O)O)F
CHEMBL565747 adrb1_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
571 15 8 9 -0.5 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCNC(=O)C(CCCN)N)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL453056 adrb1_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
475 10 3 6 2.6 CC(CC1=CC=C(C=C1)C2=CC(=C(C=C2)C(=O)O)OC3CCCCC3)NCC(C4=CN=CC=C4)O
CHEMBL565747 adrb1_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
571 15 8 9 -0.5 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCNC(=O)C(CCCN)N)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL453056 adrb1_human Human No 7.6 EC50 = 24 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
475 10 3 6 2.6 CC(CC1=CC=C(C=C1)C2=CC(=C(C=C2)C(=O)O)OC3CCCCC3)NCC(C4=CN=CC=C4)O
CHEMBL519985 adrb1_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
469 10 4 6 1.2 CC(=O)NC1=CC(=CC(=C1)C(=O)O)OC2=CC=CC(=C2)CCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL600400 adrb1_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
440 7 4 9 3.0 CC(C)(CC1=CC=C(C=C1)OC(F)(F)F)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL519985 adrb1_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
469 10 4 6 1.2 CC(=O)NC1=CC(=CC(=C1)C(=O)O)OC2=CC=CC(=C2)CCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL600400 adrb1_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
440 7 4 9 3.0 CC(C)(CC1=CC=C(C=C1)OC(F)(F)F)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL312074 adrb1_human Human No 5.6 EC50 = 2400 Funct
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
645 13 6 8 5.8 CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)C3=CC=C(C=C3)OCC4C5=CC(=C(C=C5CCN4)O)O
CHEMBL247519 adrb1_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
416 9 4 7 1.0 CC(CNC1=CC=C(C=C1)C2=C(N=CO2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL1940832 adrb1_human Human Yes 7.6 EC50 = 25.1 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
436 11 6 6 2.3 C1=CC=C(C=C1)C(CNC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NC=O)O)O
CHEMBL1940832 adrb1_human Human Yes 7.6 EC50 = 25.1 Funct
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
436 11 6 6 2.3 C1=CC=C(C=C1)C(CNC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NC=O)O)O
CHEMBL154370 adrb1_human Human No 7.6 EC50 = 25.1 Funct
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
466 11 4 4 4.5 CC1=CC=C(C=C1)CNC(=O)CC2=CC=C(C=C2)NCC(C)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL247519 adrb1_human Human No 7.6 EC50 = 25.1 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
416 9 4 7 1.0 CC(CNC1=CC=C(C=C1)C2=C(N=CO2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL1940832 adrb1_human Human Yes 7.6 EC50 = 25.1 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
436 11 6 6 2.3 C1=CC=C(C=C1)C(CNC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NC=O)O)O
CHEMBL1940832 adrb1_human Human Yes 7.6 EC50 = 25.1 Funct
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
436 11 6 6 2.3 C1=CC=C(C=C1)C(CNC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NC=O)O)O
CHEMBL466923 adrb1_human Human No 6.6 EC50 = 250 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
495 11 4 5 4.5 C1=CC=C2C(=C1)C3=C(N2)C=CC=C3OCC(CNCCC4=CC=C(C=C4)NC(=O)CC5=CC=CC=N5)O
CHEMBL272383 adrb1_human Human Yes 6.6 EC50 = 250 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
426 9 3 5 2.1 COC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL466923 adrb1_human Human No 6.6 EC50 = 250 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
495 11 4 5 4.5 C1=CC=C2C(=C1)C3=C(N2)C=CC=C3OCC(CNCCC4=CC=C(C=C4)NC(=O)CC5=CC=CC=N5)O
CHEMBL272383 adrb1_human Human Yes 6.6 EC50 = 250 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
426 9 3 5 2.1 COC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL466467 adrb1_human Human No 5.6 EC50 = 2500 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
512 14 3 6 4.3 C1=CC=C(C=C1)COC2=CC=CC(=N2)CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=CC=C4)O
CHEMBL466467 adrb1_human Human No 5.6 EC50 = 2500 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
512 14 3 6 4.3 C1=CC=C(C=C1)COC2=CC=CC(=N2)CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=CC=C4)O
CHEMBL272383 adrb1_human Human Yes 6.6 EC50 = 251 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
426 9 3 5 2.1 COC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL272383 adrb1_human Human Yes 6.6 EC50 = 251 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
426 9 3 5 2.1 COC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL1814277 adrb1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
526 17 5 7 2.7 C1=CC(=CC(=C1)N2C(=O)C=CNC2=O)CCCCOCCCCCCNCC(C3=CC(=C(C=C3)O)CO)O
CHEMBL153558 adrb1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
377 10 4 5 0.9 CC(CNC1=CC=C(C=C1)CCC(=O)O)NCC(C2=CC(=CC=C2)Cl)O
CHEMBL1940831 adrb1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
423 11 6 6 2.7 C1=CC=C(C=C1)C(CNC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)CO)O)O
CHEMBL1940830 adrb1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
423 11 6 6 2.7 C1=CC=C(C=C1)C(CNC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)CO)O)O
CHEMBL153558 adrb1_human Human No 6.6 EC50 = 251.2 Funct
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
377 10 4 5 0.9 CC(CNC1=CC=C(C=C1)CCC(=O)O)NCC(C2=CC(=CC=C2)Cl)O
CHEMBL1814277 adrb1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
526 17 5 7 2.7 C1=CC(=CC(=C1)N2C(=O)C=CNC2=O)CCCCOCCCCCCNCC(C3=CC(=C(C=C3)O)CO)O
CHEMBL153558 adrb1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
377 10 4 5 0.9 CC(CNC1=CC=C(C=C1)CCC(=O)O)NCC(C2=CC(=CC=C2)Cl)O
CHEMBL1940831 adrb1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
423 11 6 6 2.7 C1=CC=C(C=C1)C(CNC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)CO)O)O
CHEMBL1940830 adrb1_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta1-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
423 11 6 6 2.7 C1=CC=C(C=C1)C(CNC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)CO)O)O
CHEMBL206002 adrb1_human Human No 5.6 EC50 = 2511.9 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
469 10 5 7 1.8 CC(CNC1=CC=CC(=C1)C2=C(C=C(C=C2)C(=O)O)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL206002 adrb1_human Human No 5.6 EC50 = 2511.9 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
469 10 5 7 1.8 CC(CNC1=CC=CC(=C1)C2=C(C=C(C=C2)C(=O)O)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL566973 adrb1_human Human No 6.6 EC50 = 253 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
400 7 5 7 -0.9 CC(C)(CC1=CC=CC(=C1)C(=O)O)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL566973 adrb1_human Human No 6.6 EC50 = 253 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
400 7 5 7 -0.9 CC(C)(CC1=CC=CC(=C1)C(=O)O)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL319041 adrb1_human Human No 6.6 EC50 = 254 Funct
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
588 12 5 6 5.1 C1CN(CCC1NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)C(=O)NCC4=C(C=C(C=C4)Cl)Cl
CHEMBL187317 adrb1_human Human No 7.6 EC50 = 26 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
592 14 4 9 4.5 CCCCS(=O)(=O)OC1=CC=CC2=C1NC=C2CC(C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL442225 adrb1_human Human No 7.6 EC50 = 26 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
543 10 5 8 2.2 CC(CC1=CNC2=C1C=CC=C2S(=O)(=O)C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CC(=C4)N)O
CHEMBL187317 adrb1_human Human No 7.6 EC50 = 26 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
592 14 4 9 4.5 CCCCS(=O)(=O)OC1=CC=CC2=C1NC=C2CC(C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL442225 adrb1_human Human No 7.6 EC50 = 26 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
543 10 5 8 2.2 CC(CC1=CNC2=C1C=CC=C2S(=O)(=O)C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CC(=C4)N)O
CHEMBL565685 adrb1_human Human No 7.6 EC50 = 26.5 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
413 7 4 5 3.5 CC(C)(C)C1=CC=C(C=C1)CC(C)(C)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL565685 adrb1_human Human No 7.6 EC50 = 26.5 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
413 7 4 5 3.5 CC(C)(C)C1=CC=C(C=C1)CC(C)(C)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL467103 adrb1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
535 13 3 5 4.5 C1=CC=C(C=C1)OCC(CNCCC2=CC=C(C=C2)NC(=O)CC3=NC=CN3CC4=CC5=CC=CC=C5C=C4)O
CHEMBL269823 adrb1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
430 8 3 4 2.7 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC(=C(C=C3)C(=O)O)Cl)O
CHEMBL409718 adrb1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
460 10 3 5 3.3 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CC=CC=C4)O)C(=O)O
CHEMBL561693 adrb1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
421 11 4 6 2.1 C1=CC(=CC=C1CCNCC(COC2=CC=C(C=C2)O)O)NC(=O)CC3=CC=NC=C3
CHEMBL409718 adrb1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
460 10 3 5 3.3 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CC=CC=C4)O)C(=O)O
CHEMBL409718 adrb1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
460 10 3 5 3.3 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CC=CC=C4)O)C(=O)O
CHEMBL467103 adrb1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
535 13 3 5 4.5 C1=CC=C(C=C1)OCC(CNCCC2=CC=C(C=C2)NC(=O)CC3=NC=CN3CC4=CC5=CC=CC=C5C=C4)O
CHEMBL269823 adrb1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
430 8 3 4 2.7 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC(=C(C=C3)C(=O)O)Cl)O
CHEMBL409718 adrb1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
460 10 3 5 3.3 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CC=CC=C4)O)C(=O)O
CHEMBL561693 adrb1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
421 11 4 6 2.1 C1=CC(=CC=C1CCNCC(COC2=CC=C(C=C2)O)O)NC(=O)CC3=CC=NC=C3
CHEMBL409718 adrb1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
460 10 3 5 3.3 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CC=CC=C4)O)C(=O)O
CHEMBL409718 adrb1_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
460 10 3 5 3.3 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CC=CC=C4)O)C(=O)O
CHEMBL319840 adrb1_human Human No 6.6 EC50 = 260 Funct
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
537 12 5 7 3.9 C1CN(CCC1NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)C(=O)NCC4=CC=CC=C4F
CHEMBL293994 adrb1_human Human No 5.6 EC50 = 2600 Funct
In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.
593 11 3 10 4.6 C1=CC(=CN=C1)C(CNCCC2=CC=C(C=C2)NS(=O)(=O)C3=CC=C(C=C3)C4=NC(=CS4)C5=CC(=C(C=C5)F)F)O
CHEMBL108214 adrb1_human Human No 5.6 EC50 = 2640 Funct
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
618 12 6 10 2.8 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNCCC2=CC=C(C=C2)NC3CCN(CC3)C(=O)NCC4=C(C=CC(=C4)F)F)O)O
CHEMBL600617 adrb1_human Human No 7.6 EC50 = 27 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
424 6 4 8 2.7 CC(C)(CC1=CC=CC=C1C(F)(F)F)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL600617 adrb1_human Human No 7.6 EC50 = 27 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
424 6 4 8 2.7 CC(C)(CC1=CC=CC=C1C(F)(F)F)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL425173 adrb1_human Human No 7.6 EC50 = 27 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
402 11 5 5 2.0 CC(C)NC(=O)NC1=CC=C(C=C1)CC(CO)NCC(COC2=CC=CC=C2)O
CHEMBL467502 adrb1_human Human No 6.6 EC50 = 270 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
519 13 3 5 3.9 C1=CC=C(C=C1)OCC(CNCCC2=CC=C(C=C2)NC(=O)CC3=NC=CN3CC4=CC=C(C=C4)Cl)O
CHEMBL463181 adrb1_human Human No 6.6 EC50 = 270 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
482 8 3 7 1.8 CN(C)C1=CC(=CC(=C1)C(=O)O)OC2=CC3=C(CCC(C3)NCC(C4=CN=C(C=C4)Cl)O)C=C2
CHEMBL467502 adrb1_human Human No 6.6 EC50 = 270 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
519 13 3 5 3.9 C1=CC=C(C=C1)OCC(CNCCC2=CC=C(C=C2)NC(=O)CC3=NC=CN3CC4=CC=C(C=C4)Cl)O
CHEMBL463181 adrb1_human Human No 6.6 EC50 = 270 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
482 8 3 7 1.8 CN(C)C1=CC(=CC(=C1)C(=O)O)OC2=CC3=C(CCC(C3)NCC(C4=CN=C(C=C4)Cl)O)C=C2
CHEMBL466705 adrb1_human Human No 5.6 EC50 = 2700 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
421 11 4 6 2.2 C1=CC=NC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL466705 adrb1_human Human No 5.6 EC50 = 2700 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
421 11 4 6 2.2 C1=CC=NC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL331744 adrb1_human Human No 5.6 EC50 = 2700 Funct
In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.
641 12 3 12 5.6 C1=CC(=CN=C1)C(CNCCC2=CC=C(C=C2)NS(=O)(=O)C3=CC=C(C=C3)C4=NC(=CS4)C5=CC=C(C=C5)OC(F)(F)F)O
CHEMBL163262 adrb1_human Human No 5.6 EC50 = 2720 Funct
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
535 9 5 10 1.8 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNC2CCN(CC2)C3=CC=C(C=C3)CC4C(=O)NC(=O)S4)O)O
CHEMBL600817 adrb1_human Human No 5.6 EC50 = 2725 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
386 7 4 6 1.8 CC(C)(CC1=CC=C(C=C1)OC)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL600817 adrb1_human Human No 5.6 EC50 = 2725 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
386 7 4 6 1.8 CC(C)(CC1=CC=C(C=C1)OC)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL604125 adrb1_human Human No 6.6 EC50 = 278.4 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
386 7 4 6 1.8 CC(C)(CC1=CC(=CC=C1)OC)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL604125 adrb1_human Human No 6.6 EC50 = 278.4 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
386 7 4 6 1.8 CC(C)(CC1=CC(=CC=C1)OC)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL492006 adrb1_human Human No 7.6 EC50 = 28 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
426 9 3 5 2.4 CC(CC1=CC(=CC=C1)OC2=CC=CC(=C2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL509156 adrb1_human Human No 7.6 EC50 = 28 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
474 10 3 5 3.7 CC(CC1=CC=C(C=C1)C2=CC(=C(C=C2)C(=O)O)OC3CCCCC3)NCC(C4=CC=CC=C4)O
CHEMBL492006 adrb1_human Human No 7.6 EC50 = 28 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
426 9 3 5 2.4 CC(CC1=CC(=CC=C1)OC2=CC=CC(=C2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL509156 adrb1_human Human No 7.6 EC50 = 28 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
474 10 3 5 3.7 CC(CC1=CC=C(C=C1)C2=CC(=C(C=C2)C(=O)O)OC3CCCCC3)NCC(C4=CC=CC=C4)O
CHEMBL466925 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
434 11 3 5 3.3 CC1=CC(=NC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=CC=C3)O)C
CHEMBL467116 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
499 13 2 5 3.5 CN(C1=CC=C(C=C1)CCNCC(COC2=CC=CC=C2)O)C(=O)CC3=NC=CN3CC4=CC=CC=C4
CHEMBL466519 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
462 11 5 6 1.2 C1=CC=NC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=CC4=C3NC(=O)N4)O
CHEMBL271576 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
396 8 3 4 2.1 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)O)O
CHEMBL271576 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
396 8 3 4 2.1 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)O)O
CHEMBL551350 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
451 12 4 6 3.2 COC1=CC=C(C=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL271576 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
396 8 3 4 2.1 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)O)O
CHEMBL453323 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
448 10 3 5 2.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CC(C)(C)NCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL466925 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
434 11 3 5 3.3 CC1=CC(=NC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=CC=C3)O)C
CHEMBL467116 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
499 13 2 5 3.5 CN(C1=CC=C(C=C1)CCNCC(COC2=CC=CC=C2)O)C(=O)CC3=NC=CN3CC4=CC=CC=C4
CHEMBL466519 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
462 11 5 6 1.2 C1=CC=NC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=CC4=C3NC(=O)N4)O
CHEMBL271576 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
396 8 3 4 2.1 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)O)O
CHEMBL271576 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
396 8 3 4 2.1 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)O)O
CHEMBL551350 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
451 12 4 6 3.2 COC1=CC=C(C=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL271576 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
396 8 3 4 2.1 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)O)O
CHEMBL453323 adrb1_human Human No 6.6 EC50 = 280 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
448 10 3 5 2.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CC(C)(C)NCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL143645 b0fl73_cavpo Guinea pig No 5.6 EC50 = 2818.4 Funct
Inhibitory activity against Beta-1 adrenergic receptor in guinea pig atria after treatment with the compoundInhibitory activity against Beta-1 adrenergic receptor in guinea pig atria after treatment with the compound
413 5 3 9 3.4 COC1=CC(=CC(=C1OC)OC)CC2C3=CC(=C(C(=C3CCN2)C(F)(F)F)O)O
CHEMBL166085 adrb1_human Human No 5.5 EC50 = 2860 Funct
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
472 9 4 8 3.0 C1CN(CCC1NCC(COC2=CC=C(C=C2)O)O)C3=CC=C(C=C3)CC4C(=O)NC(=O)S4
CHEMBL362136 adrb1_human Human No 7.5 EC50 = 29 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
515 12 5 8 2.7 CC(CC1=CNC2=C1C=CC=C2OCCN)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL361505 adrb1_human Human No 7.5 EC50 = 29 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
486 10 4 7 3.7 CC(CC1=CNC2=C1C=CC=C2OC)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL362136 adrb1_human Human No 7.5 EC50 = 29 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
515 12 5 8 2.7 CC(CC1=CNC2=C1C=CC=C2OCCN)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL361505 adrb1_human Human No 7.5 EC50 = 29 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
486 10 4 7 3.7 CC(CC1=CNC2=C1C=CC=C2OC)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL466705 adrb1_human Human No 6.5 EC50 = 290 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
421 11 4 6 2.2 C1=CC=NC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL551272 adrb1_human Human No 6.5 EC50 = 290 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
527 11 4 7 3.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNC(C)C(C3=CC=C(C=C3)O)O)C(=O)NS(=O)(=O)C
CHEMBL466705 adrb1_human Human No 6.5 EC50 = 290 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
421 11 4 6 2.2 C1=CC=NC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL551272 adrb1_human Human No 6.5 EC50 = 290 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
527 11 4 7 3.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNC(C)C(C3=CC=C(C=C3)O)O)C(=O)NS(=O)(=O)C
CHEMBL566777 adrb1_human Human No 6.5 EC50 = 294 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
329 7 4 4 2.9 CC1=CC=CC=C1CC(C)(C)NCC(C2=CC(=C(C=C2)O)CO)O
CHEMBL566777 adrb1_human Human No 6.5 EC50 = 294 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
329 7 4 4 2.9 CC1=CC=CC=C1CC(C)(C)NCC(C2=CC(=C(C=C2)O)CO)O
CHEMBL341654 b0fl73_cavpo Guinea pig No 5.5 EC50 = 2951.2 Funct
Inhibitory activity against Beta-1 adrenergic receptor in guinea pig atria after treatment with the compoundInhibitory activity against Beta-1 adrenergic receptor in guinea pig atria after treatment with the compound
471 5 3 6 3.2 COC1=CC(=CC(=C1OC)OC)CC2C3=C(C(=C(C=C3CCN2)O)O)I
CHEMBL1682220 adrb1_rat Rat No 6.5 EC50 = 296 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
531 9 6 5 3.6 C1C2CC3CC1CC(C2)(C3)CNC(=O)NC4=CC=CC(=C4)CCNCC(C5=C6C=CC(=O)NC6=C(C=C5)O)O
CHEMBL1682220 adrb1_rat Rat No 6.5 EC50 = 296 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
531 9 6 5 3.6 C1C2CC3CC1CC(C2)(C3)CNC(=O)NC4=CC=CC(=C4)CCNCC(C5=C6C=CC(=O)NC6=C(C=C5)O)O
CHEMBL486278 adrb1_human Human No 8.5 EC50 = 3 Funct
Binding affinity to beta-1 adrenoceptorBinding affinity to beta-1 adrenoceptor
385 9 4 5 2.0 CC(C)(CC1=CC=C(C=C1)OC)NCC(COC2=CC=CC3=C2NC(=O)N3)O
CHEMBL267306 adrb1_human Human No 8.5 EC50 = 3 Funct
Agonist activity against cloned human beta-1 adrenergic receptor as percent activation of adenyl cyclase activity at a concentration of 1000 nMAgonist activity against cloned human beta-1 adrenergic receptor as percent activation of adenyl cyclase activity at a concentration of 1000 nM
477 11 4 7 3.6 C1=CC=C(C(=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)Cl
CHEMBL183211 adrb1_human Human No 8.5 EC50 = 3 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
421 10 5 5 2.8 C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)CC(NCC(COC3=CC=CC=C3)O)O
CHEMBL486278 adrb1_human Human No 8.5 EC50 = 3 Funct
Binding affinity to beta-1 adrenoceptorBinding affinity to beta-1 adrenoceptor
385 9 4 5 2.0 CC(C)(CC1=CC=C(C=C1)OC)NCC(COC2=CC=CC3=C2NC(=O)N3)O
CHEMBL76403 adrb1_human Human No 8.5 EC50 = 3 Funct
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR) at a concentration of 10000 nmCompound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR) at a concentration of 10000 nm
619 12 6 8 5.4 CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC3=C(C=C2)C=C(C=C3)OCC4C5=CC(=C(C=C5CCN4)O)O
CHEMBL2348201 adrb1_human Human No 8.5 EC50 = 3.0 Funct
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
492 14 4 6 3.3 C1CCC(C1)OCCOC2=CC=C(C=C2)OCC(CNCCNC(=O)NC3=CC(=CC=C3)Cl)O
CHEMBL257106 adrb1_human Human No 8.5 EC50 = 3.1 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
430 8 3 4 2.7 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC(=C(C=C2)C3=CC=C(C=C3)C(=O)O)Cl)O
CHEMBL187209 adrb1_human Human No 8.5 EC50 = 3.1 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
612 12 4 9 4.8 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C3=CC=CC=C3)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL257106 adrb1_human Human No 8.5 EC50 = 3.1 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
430 8 3 4 2.7 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC(=C(C=C2)C3=CC=C(C=C3)C(=O)O)Cl)O
CHEMBL154150 adrb1_human Human No 8.5 EC50 = 3.2 Funct
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
445 10 4 6 3.5 CC(CNC1=CC=C(C=C1)CC(=O)NC2=NC=CS2)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL577702 adrb1_human Human No 8.5 EC50 = 3.4 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
457 10 6 7 0.3 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCN)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL577702 adrb1_human Human No 8.5 EC50 = 3.4 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
457 10 6 7 0.3 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCN)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL1257555 adrb1_human Human No 8.5 EC50 = 3.5 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
507 9 4 9 4.1 C1CN(CCC1NCC(COC2=CC(=C(C=C2)O)CO)O)C3=C4C(=CSC4=NC=N3)C5=CC=CC=C5
CHEMBL1257555 adrb1_human Human No 8.5 EC50 = 3.5 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
507 9 4 9 4.1 C1CN(CCC1NCC(COC2=CC(=C(C=C2)O)CO)O)C3=C4C(=CSC4=NC=N3)C5=CC=CC=C5
CHEMBL568531 adrb1_human Human No 8.4 EC50 = 3.6 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
440 7 4 9 3.0 CC(C)(CC1=CC=C(C=C1)OC(F)(F)F)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL568531 adrb1_human Human No 8.4 EC50 = 3.6 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
440 7 4 9 3.0 CC(C)(CC1=CC=C(C=C1)OC(F)(F)F)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL2348219 adrb1_human Human No 8.4 EC50 = 3.6 Funct
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
474 14 5 7 2.3 C1CCC(C1)OCCOC2=CC=C(C=C2)OCC(CNCCNC(=O)NC3=CC=C(C=C3)O)O
CHEMBL584498 adrb1_human Human No 8.4 EC50 = 3.7 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
424 6 4 8 2.7 CC(C)(CC1=CC=C(C=C1)C(F)(F)F)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL568273 adrb1_human Human No 8.4 EC50 = 3.7 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
424 6 4 8 2.7 CC(C)(CC1=CC(=CC=C1)C(F)(F)F)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL584498 adrb1_human Human No 8.4 EC50 = 3.7 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
424 6 4 8 2.7 CC(C)(CC1=CC=C(C=C1)C(F)(F)F)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL568273 adrb1_human Human No 8.4 EC50 = 3.7 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
424 6 4 8 2.7 CC(C)(CC1=CC(=CC=C1)C(F)(F)F)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL409827 adrb1_human Human No 8.4 EC50 = 3.9 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
411 9 4 5 2.0 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)NC3=CC=C(C=C3)C(=O)O)O
CHEMBL409827 adrb1_human Human No 8.4 EC50 = 3.9 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
411 9 4 5 2.0 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)NC3=CC=C(C=C3)C(=O)O)O
CHEMBL1807819 adrb1_human Human No 8.4 EC50 = 4.0 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
463 14 4 7 3.2 C1=CC=C(C=C1)CCOCCCSCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1807819 adrb1_human Human No 8.4 EC50 = 4.0 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
463 14 4 7 3.2 C1=CC=C(C=C1)CCOCCCSCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL3298325 adrb1_human Human No 8.4 EC50 = 4.0 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
551 11 6 7 3.7 COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)C5=CC(=CC=C5)CN
CHEMBL3298325 adrb1_human Human No 8.4 EC50 = 4.0 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
551 11 6 7 3.7 COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)C5=CC(=CC=C5)CN
CHEMBL257297 adrb1_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
430 8 3 4 2.7 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=C(C=C(C=C3)C(=O)O)Cl)O
CHEMBL257297 adrb1_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
430 8 3 4 2.7 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=C(C=C(C=C3)C(=O)O)Cl)O
CHEMBL317003 adrb1_human Human No 7.5 EC50 = 30 Funct
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
657 12 5 11 -0.2 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNCC2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)N4C=C(C5=CC=CC=C54)CC(=O)O)O)O
CHEMBL408694 adrb1_human Human No 6.5 EC50 = 300 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
410 9 3 4 2.0 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC=C(C=C3)CC(=O)O)O
CHEMBL451760 adrb1_human Human No 6.5 EC50 = 300 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
432 10 3 4 3.5 CC(C)CC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNC(C)C(C3=CC=CC=C3)O)C(=O)O
CHEMBL408694 adrb1_human Human No 6.5 EC50 = 300 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
410 9 3 4 2.0 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC=C(C=C3)CC(=O)O)O
CHEMBL451760 adrb1_human Human No 6.5 EC50 = 300 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
432 10 3 4 3.5 CC(C)CC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNC(C)C(C3=CC=CC=C3)O)C(=O)O
CHEMBL287587 b0fl73_cavpo Guinea pig Yes 6.5 EC50 = 300 Funct
Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsBeta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations
187 2 4 5 -0.5 C1=CC(=C(C(=C1C(CN)O)F)O)O
CHEMBL12769 adrb1_human Human No 6.5 EC50 = 300 Funct
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
494 11 4 8 3.2 C1=CC=C2C(=C1)C=C(C=N2)S(=O)(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL1807832 adrb1_human Human No 7.5 EC50 = 31.6 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
466 13 5 7 2.4 C1=CC(=CC(=C1)Cl)CCNCCCOCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1807832 adrb1_human Human No 7.5 EC50 = 31.6 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
466 13 5 7 2.4 C1=CC(=CC(=C1)Cl)CCNCCCOCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1086077 adrb1_human Human No 6.5 EC50 = 310 Funct
Agonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assayAgonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assay
447 7 2 5 5.2 C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CC(COC3=CC=CC4=C3C5=CC=CC=C5N4)O
CHEMBL457199 adrb1_human Human No 6.5 EC50 = 310 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
480 8 3 5 3.3 CC(C)OC1=C(C=CC(=C1)C2=CC3=C(CCC(C3)NCC(C4=CC=C(C=C4)Cl)O)C=C2)C(=O)O
CHEMBL1086077 adrb1_human Human No 6.5 EC50 = 310 Funct
Agonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assayAgonist activity at human adrenergic beta-1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF assay
447 7 2 5 5.2 C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CC(COC3=CC=CC4=C3C5=CC=CC=C5N4)O
CHEMBL457199 adrb1_human Human No 6.5 EC50 = 310 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
480 8 3 5 3.3 CC(C)OC1=C(C=CC(=C1)C2=CC3=C(CCC(C3)NCC(C4=CC=C(C=C4)Cl)O)C=C2)C(=O)O
CHEMBL552497 adrb1_human Human No 5.5 EC50 = 3100 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
422 11 4 7 1.1 C1=CC(=CC=C1CCNCC(COC2=CC=C(C=C2)O)O)NC(=O)CC3=NC=CN=C3
CHEMBL552497 adrb1_human Human No 5.5 EC50 = 3100 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
422 11 4 7 1.1 C1=CC(=CC=C1CCNCC(COC2=CC=C(C=C2)O)O)NC(=O)CC3=NC=CN=C3
CHEMBL99219 adrb1_human Human No 5.5 EC50 = 3160 Funct
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
668 12 6 12 1.5 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNCC2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)NC(=O)NCC4=C(C=CC(=C4)F)F)O)O
CHEMBL205389 adrb1_human Human No 5.5 EC50 = 3162.3 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
412 9 4 6 0.8 C1=CC(=CC(=C1)NCCNCC(C2=CC(=CC=C2)Cl)O)C3=CC(=CN=C3)C(=O)O
CHEMBL205389 adrb1_human Human No 5.5 EC50 = 3162.3 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
412 9 4 6 0.8 C1=CC(=CC(=C1)NCCNCC(C2=CC(=CC=C2)Cl)O)C3=CC(=CN=C3)C(=O)O
CHEMBL516804 adrb1_human Human No 6.5 EC50 = 320 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
438 10 3 6 2.3 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)F)O)C(=O)O
CHEMBL516804 adrb1_human Human No 6.5 EC50 = 320 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
438 10 3 6 2.3 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)F)O)C(=O)O
CHEMBL276257 adrb1_human Human Yes 6.5 EC50 = 320 Funct
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
568 11 4 7 3.6 C1=CC(=CC=C1CCNCC(COC2=CC=C(C=C2)O)O)NS(=O)(=O)C3=CC=C(C=C3)I
CHEMBL577289 adrb1_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
400 7 5 7 -0.9 CC(C)(CC1=CC=C(C=C1)C(=O)O)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL577289 adrb1_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
400 7 5 7 -0.9 CC(C)(CC1=CC=C(C=C1)C(=O)O)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL466924 adrb1_human Human No 6.5 EC50 = 330 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
420 11 3 5 2.9 CC1=C(N=CC=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=CC=C3)O
CHEMBL456578 adrb1_human Human No 6.5 EC50 = 330 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
438 7 3 5 2.5 C1CC2=C(CC1NCC(C3=CC=C(C=C3)Cl)O)C=C(C=C2)OC4=CC=CC(=C4)C(=O)O
CHEMBL466924 adrb1_human Human No 6.5 EC50 = 330 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
420 11 3 5 2.9 CC1=C(N=CC=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=CC=C3)O
CHEMBL456578 adrb1_human Human No 6.5 EC50 = 330 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
438 7 3 5 2.5 C1CC2=C(CC1NCC(C3=CC=C(C=C3)Cl)O)C=C(C=C2)OC4=CC=CC(=C4)C(=O)O
CHEMBL12998 adrb1_human Human Yes 6.5 EC50 = 330 Funct
In vitro activity to increase cAMP levels in Chinese hamster ovary (CHO) cells expressing the cloned human beta 1 Adrenergic receptorIn vitro activity to increase cAMP levels in Chinese hamster ovary (CHO) cells expressing the cloned human beta 1 Adrenergic receptor
585 17 6 8 4.3 CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL515349 adrb1_human Human No 6.5 EC50 = 340 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
537 9 4 7 2.8 C1CC2=C(CC1NCC(C3=CC(=CC=C3)Cl)O)C=C(C=C2)OC4=CC(=CC(=C4)NC5CCOCC5)C(=O)O
CHEMBL515349 adrb1_human Human No 6.5 EC50 = 340 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
537 9 4 7 2.8 C1CC2=C(CC1NCC(C3=CC(=CC=C3)Cl)O)C=C(C=C2)OC4=CC(=CC(=C4)NC5CCOCC5)C(=O)O
CHEMBL267545 adrb1_human Human No 6.5 EC50 = 340 Funct
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
521 11 4 7 3.7 C1=CC(=CC=C1CCNCC(COC2=CC=C(C=C2)O)O)NS(=O)(=O)C3=CC=C(C=C3)Br
CHEMBL592879 adrb1_human Human No 7.5 EC50 = 35 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
356 6 4 5 1.8 CC(C)(CC1=CC=CC=C1)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL592879 adrb1_human Human No 7.5 EC50 = 35 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
356 6 4 5 1.8 CC(C)(CC1=CC=CC=C1)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL466088 adrb1_human Human No 6.5 EC50 = 350 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
499 13 3 5 3.7 CC(CC1=CC=C(C=C1)NC(=O)CC2=NC=CN2CC3=CC=CC=C3)NCC(COC4=CC=CC=C4)O
CHEMBL272583 adrb1_human Human No 6.5 EC50 = 350 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
468 11 3 5 3.4 CC(C)COC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL562153 adrb1_human Human No 6.5 EC50 = 350 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
472 11 4 6 3.4 C1=CC=C2C=NC(=CC2=C1)CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL272583 adrb1_human Human No 6.5 EC50 = 350 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
468 11 3 5 3.4 CC(C)COC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL562153 adrb1_human Human No 6.5 EC50 = 350 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
472 11 4 6 3.4 C1=CC=C2C=NC(=CC2=C1)CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL107012 adrb1_human Human No 6.5 EC50 = 350 Funct
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
443 10 5 6 2.3 CNC(=O)N1CCC(CC1)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL431048 adrb1_human Human No 6.5 EC50 = 353 Funct
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
698 14 6 13 1.7 CS(=O)(=O)NC1=C(C=CC(=C1)OCC(CNCC2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)NC(=O)NCC4=C(C=CC(=C4)F)F)O)O
CHEMBL603271 adrb1_human Human Yes 6.5 EC50 = 358 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
386 7 4 6 1.8 CC(C)(CC1=CC=C(C=C1)OC)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL603271 adrb1_human Human Yes 6.5 EC50 = 358 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
386 7 4 6 1.8 CC(C)(CC1=CC=C(C=C1)OC)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL273098 adrb1_human Human No 7.4 EC50 = 36 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
411 9 4 5 2.0 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)NC3=CC=CC(=C3)C(=O)O)O
CHEMBL182770 adrb1_human Human No 7.4 EC50 = 36 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
472 11 4 6 4.2 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C)NCC(C3=CC(=CC=C3)NCC=C(C)C)O
CHEMBL273098 adrb1_human Human No 7.4 EC50 = 36 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
411 9 4 5 2.0 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)NC3=CC=CC(=C3)C(=O)O)O
CHEMBL456353 adrb1_human Human No 6.4 EC50 = 360 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
495 8 4 6 1.6 CC(=O)NC1=CC(=CC(=C1)C(=O)O)OC2=CC3=C(CCC(C3)NCC(C4=CC(=CC=C4)Cl)O)C=C2
CHEMBL456353 adrb1_human Human No 6.4 EC50 = 360 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
495 8 4 6 1.6 CC(=O)NC1=CC(=CC(=C1)C(=O)O)OC2=CC3=C(CCC(C3)NCC(C4=CC(=CC=C4)Cl)O)C=C2
CHEMBL281232 b0fl73_cavpo Guinea pig Yes 4.4 EC50 = 36000 Funct
Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparationsBeta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations
187 2 4 5 -0.5 C1=C(C(=CC(=C1O)O)F)C(CN)O
CHEMBL487443 adrb1_human Human No 7.4 EC50 = 37 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
468 10 3 5 3.3 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CC(C)NCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL487443 adrb1_human Human No 7.4 EC50 = 37 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
468 10 3 5 3.3 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CC(C)NCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL22318 adrb1_human Human No 6.4 EC50 = 370 Funct
Agonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclaseAgonistic activity against the cloned human Beta-1 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclase
594 17 3 9 5.4 CCCCCCCCN1C(=O)N(N=N1)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=C(C=C3)CCNCC(C4=CN=CC=C4)O
CHEMBL271367 adrb1_human Human No 6.4 EC50 = 380 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
414 8 3 5 2.2 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC(=C(C=C3)C(=O)O)F)O
CHEMBL489200 adrb1_human Human No 6.4 EC50 = 380 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
469 10 4 6 1.7 CC(=O)NC1=C(C=C(C=C1)OC2=CC=CC(=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL271367 adrb1_human Human No 6.4 EC50 = 380 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
414 8 3 5 2.2 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)C3=CC(=C(C=C3)C(=O)O)F)O
CHEMBL489200 adrb1_human Human No 6.4 EC50 = 380 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
469 10 4 6 1.7 CC(=O)NC1=C(C=C(C=C1)OC2=CC=CC(=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL529659 adrb1_human Human No 7.4 EC50 = 39 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
476 10 4 7 1.8 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CN=C(C=C4)N)O)C(=O)O
CHEMBL470857 adrb1_human Human No 7.4 EC50 = 39 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
476 10 4 7 2.1 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=C(C=CN=C4)N)O)C(=O)O
CHEMBL529659 adrb1_human Human No 7.4 EC50 = 39 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
476 10 4 7 1.8 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CN=C(C=C4)N)O)C(=O)O
CHEMBL470857 adrb1_human Human No 7.4 EC50 = 39 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
476 10 4 7 2.1 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=C(C=CN=C4)N)O)C(=O)O
CHEMBL1346 adrb1_human Human Yes 7.4 EC50 = 39.8 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
427 7 1 3 4.6 C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5
CHEMBL1807872 adrb1_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
466 13 5 7 2.4 C1=CC(=CC(=C1)Cl)CCNCCOCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1807830 adrb1_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
498 13 5 8 1.6 C1=CC(=CC(=C1)Cl)CCNCCCS(=O)CCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1807870 adrb1_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
482 13 5 7 3.2 C1=CC=C(C(=C1)CCNCCSCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O)Cl
CHEMBL1256786 adrb1_human Human Yes 7.4 EC50 = 39.8 Funct
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
344 8 4 5 1.8 CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
CHEMBL1256786 adrb1_human Human Yes 7.4 EC50 = 39.8 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
344 8 4 5 1.8 CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
CHEMBL1346 adrb1_human Human Yes 7.4 EC50 = 39.8 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
427 7 1 3 4.6 C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5
CHEMBL1807872 adrb1_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
466 13 5 7 2.4 C1=CC(=CC(=C1)Cl)CCNCCOCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1807830 adrb1_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
498 13 5 8 1.6 C1=CC(=CC(=C1)Cl)CCNCCCS(=O)CCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1807870 adrb1_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
482 13 5 7 3.2 C1=CC=C(C(=C1)CCNCCSCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O)Cl
CHEMBL1363 adrb1_human Human Yes 7.4 EC50 = 39.8 Funct
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation
344 8 4 5 1.8 CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
CHEMBL1256786 adrb1_human Human Yes 7.4 EC50 = 39.8 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
344 8 4 5 1.8 CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
CHEMBL490733 adrb1_human Human No 6.4 EC50 = 390 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
529 11 4 8 3.2 CC(C)SC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=C(C=CN=C3)N)O)C(=O)NS(=O)(=O)C
CHEMBL490733 adrb1_human Human No 6.4 EC50 = 390 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
529 11 4 8 3.2 CC(C)SC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=C(C=CN=C3)N)O)C(=O)NS(=O)(=O)C
CHEMBL327519 adrb1_human Human No 6.4 EC50 = 390 Funct
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
660 17 6 9 3.6 CCCCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCC(CC2)CNCC(COC3=C4CCC(=O)NC4=C(C=C3)O)O
CHEMBL393471 adrb1_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
416 9 4 7 1.0 CC(CNC1=CC=CC(=C1)C2=C(N=CO2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL393471 adrb1_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
416 9 4 7 1.0 CC(CNC1=CC=CC(=C1)C2=C(N=CO2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL154906 adrb1_human Human No 6.4 EC50 = 398.1 Funct
Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.Concentration that causes 50% inhibition of human beta 1 adrenergic receptor (AR), expressed in CHO cells.
517 11 5 6 3.5 CC(CNC1=CC=CC(=C1)CNC(=O)NS(=O)(=O)C2=CC=CC=C2)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL208427 adrb1_human Human Yes 5.4 EC50 = 3981.1 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
411 9 4 5 1.8 C1=CC(=CC(=C1)C(=O)O)C2=CC(=CC=C2)NCCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL245875 adrb1_human Human No 5.4 EC50 = 3981.1 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
417 9 4 6 1.5 C1=CC(=CC(=C1)NCCNCC(C2=CC(=CC=C2)Cl)O)C3=C(C=CS3)C(=O)O
CHEMBL208427 adrb1_human Human Yes 5.4 EC50 = 3981.1 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
411 9 4 5 1.8 C1=CC(=CC(=C1)C(=O)O)C2=CC(=CC=C2)NCCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL245875 adrb1_human Human No 5.4 EC50 = 3981.1 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
417 9 4 6 1.5 C1=CC(=CC(=C1)NCCNCC(C2=CC(=CC=C2)Cl)O)C3=C(C=CS3)C(=O)O
CHEMBL183611 adrb1_human Human No 8.4 EC50 = 4 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
466 12 5 6 2.7 COC1=CC=CC(=C1)NC(=O)NC2=CC=C(C=C2)CC(CO)NCC(COC3=CC=CC=C3)O
CHEMBL2348211 adrb1_human Human No 8.4 EC50 = 4.5 Funct
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
458 14 4 6 2.6 C1CCC(C1)OCCOC2=CC=C(C=C2)OCC(CNCCNC(=O)NC3=CC=CC=C3)O
CHEMBL583235 adrb1_human Human No 8.4 EC50 = 4.5 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
514 12 7 8 -0.3 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCNC(=O)CN)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL601036 adrb1_human Human No 8.4 EC50 = 4.5 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
370 6 4 5 2.2 CC1=CC=CC=C1CC(C)(C)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL583235 adrb1_human Human No 8.4 EC50 = 4.5 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
514 12 7 8 -0.3 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCNC(=O)CN)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL601036 adrb1_human Human No 8.4 EC50 = 4.5 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
370 6 4 5 2.2 CC1=CC=CC=C1CC(C)(C)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL568239 adrb1_human Human No 8.3 EC50 = 4.6 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
528 13 7 8 -0.4 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCNC(=O)CCN)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL568239 adrb1_human Human No 8.3 EC50 = 4.6 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
528 13 7 8 -0.4 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCNC(=O)CCN)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL266619 b0fl73_cavpo Guinea pig Yes 8.3 EC50 = 4.7 Funct
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atriaAgonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria
255 6 4 5 1.1 CC(C)(C)NCC(COC1=CC(=C(C=C1)O)O)O
CHEMBL185660 adrb1_human Human No 7.4 EC50 = 40 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
578 12 4 9 4.0 CC(C)S(=O)(=O)OC1=CC=CC2=C1NC=C2CC(C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL185660 adrb1_human Human No 7.4 EC50 = 40 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
578 12 4 9 4.0 CC(C)S(=O)(=O)OC1=CC=CC2=C1NC=C2CC(C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL418600 adrb1_human Human No 7.4 EC50 = 40 Funct
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
563 13 5 10 -0.3 CCCCN(C1=CC=C(C=C1)N2CCC(CC2)NCC(C3=CC(=C(C=C3)O)NS(=O)(=O)C)O)C(=O)CC(=O)O
CHEMBL460257 adrb1_human Human No 6.4 EC50 = 400 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
450 12 3 6 2.5 CC(C)COC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL460257 adrb1_human Human No 6.4 EC50 = 400 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
450 12 3 6 2.5 CC(C)COC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL431678 adrb1_human Human No 7.4 EC50 = 41 Funct
Binding affinity towards human Beta-1 adrenergic receptorBinding affinity towards human Beta-1 adrenergic receptor
685 13 4 12 6.9 C1CN(C2=C1C=C(C=C2)NC(=NC3=CC=C(C=C3)CCNCC(C4=CN=CC=C4)O)NC#N)C5=NC(=CS5)C6=CC=C(C=C6)OC(F)(F)F
CHEMBL103137 adrb1_human Human No 6.4 EC50 = 417 Funct
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
450 9 3 7 5.0 C1CN(CCC1CNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O)CCC(F)(F)F
CHEMBL602257 adrb1_human Human No 7.4 EC50 = 42 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
370 6 4 5 2.2 CC1=CC(=CC=C1)CC(C)(C)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL602257 adrb1_human Human No 7.4 EC50 = 42 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
370 6 4 5 2.2 CC1=CC(=CC=C1)CC(C)(C)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL106511 adrb1_human Human No 6.4 EC50 = 423 Funct
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
648 14 6 11 3.0 CS(=O)(=O)NC1=C(C=CC(=C1)OCC(CNCCC2=CC=C(C=C2)NC3CCN(CC3)C(=O)NCC4=C(C=CC(=C4)F)F)O)O
CHEMBL466726 adrb1_human Human No 7.4 EC50 = 43 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
440 11 3 5 3.5 C1=CC=C(C=C1)OCC(CNCCC2=CC=C(C=C2)NC(=O)CC3=NC(=CC=C3)Cl)O
CHEMBL466726 adrb1_human Human No 7.4 EC50 = 43 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
440 11 3 5 3.5 C1=CC=C(C=C1)OCC(CNCCC2=CC=C(C=C2)NC(=O)CC3=NC(=CC=C3)Cl)O
CHEMBL424167 adrb1_human Human No 6.4 EC50 = 430 Funct
Agonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptorAgonistic activity as cAMP accumulation in CHO cells expressing human beta-1-adrenergic receptor
597 10 5 10 3.3 C1CN(CCC1NCC(C2=CC(=C(C=C2)O)NS(=O)(=O)C3=CC=CC=C3)O)C4=CC=C(C=C4)CC5C(=O)NC(=O)S5
CHEMBL604333 adrb1_human Human No 6.4 EC50 = 436.5 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
424 6 4 8 2.7 CC(C)(CC1=CC(=CC=C1)C(F)(F)F)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL604333 adrb1_human Human No 6.4 EC50 = 436.5 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
424 6 4 8 2.7 CC(C)(CC1=CC(=CC=C1)C(F)(F)F)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL32599 adrb1_human Human No 4.4 EC50 = 43700 Funct
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
597 12 6 10 0.2 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNC2CCN(CC2)C3=CC=C(C=C3)C(=O)NC(CC4=CC=CC=C4)C(=O)O)O)O
CHEMBL184407 adrb1_human Human No 7.4 EC50 = 44 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
550 11 4 9 3.2 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL2260989 adrb1_human Human No 7.4 EC50 = 44 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
512 9 3 7 3.7 CC(CC1=CN2CCCOC3=CC=CC1=C32)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL183552 adrb1_human Human No 7.4 EC50 = 44 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
544 11 4 6 5.4 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C)NCC(C3=CC(=CC=C3)NCC4=CC5=CC=CC=C5C=C4)O
CHEMBL184407 adrb1_human Human No 7.4 EC50 = 44 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
550 11 4 9 3.2 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL518168 adrb1_human Human No 6.4 EC50 = 440 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
436 10 4 6 1.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)O)O)C(=O)O
CHEMBL518168 adrb1_human Human No 6.4 EC50 = 440 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
436 10 4 6 1.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)O)O)C(=O)O
CHEMBL181300 adrb1_human Human No 7.4 EC50 = 45 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor
442 10 4 6 2.8 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C)NCC(C3=CC(=CC=C3)NCC#C)O
CHEMBL1258024 adrb1_human Human No 6.4 EC50 = 450 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
491 9 2 8 4.8 COC1=CC(=CC=C1)OCC(CNC2CCN(CC2)C3=C4C(=CSC4=NC=N3)C5=CC=CC=C5)O
CHEMBL1258024 adrb1_human Human No 6.4 EC50 = 450 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
491 9 2 8 4.8 COC1=CC(=CC=C1)OCC(CNC2CCN(CC2)C3=C4C(=CSC4=NC=N3)C5=CC=CC=C5)O
CHEMBL12450 adrb1_human Human No 6.4 EC50 = 450 Funct
Compound was tested for agonist activity against cloned human beta-1 adrenergic receptorCompound was tested for agonist activity against cloned human beta-1 adrenergic receptor
477 11 4 7 3.6 C1=CC(=CC=C1CCNCC(COC2=CC=C(C=C2)O)O)NS(=O)(=O)C3=CC=C(C=C3)Cl
CHEMBL286868 adrb1_human Human No 5.4 EC50 = 4500 Funct
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
535 12 5 10 1.2 CCOC(=O)CNC(=O)C1=CC=C(C=C1)N2CCC(CC2)NCC(C3=CC(=C(C=C3)O)NS(=O)(=O)C)O
CHEMBL108263 adrb1_human Human No 6.3 EC50 = 460 Funct
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
555 12 5 8 4.0 C1CN(CCC1NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)C(=O)NCC4=C(C=C(C=C4)F)F
CHEMBL279931 adrb1_human Human No 7.3 EC50 = 47 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
329 6 3 2 3.8 CC(CC1=CNC2=CC=CC=C21)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL279931 adrb1_human Human No 7.3 EC50 = 47 Funct
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
329 6 3 2 3.8 CC(CC1=CNC2=CC=CC=C21)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL514094 adrb1_human Human No 6.3 EC50 = 480 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
453 7 4 6 1.8 C1CC2=C(CC1NCC(C3=CC(=CC=C3)Cl)O)C=C(C=C2)OC4=CC(=CC(=C4)N)C(=O)O
CHEMBL488224 adrb1_human Human No 6.3 EC50 = 480 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
461 10 3 6 2.2 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CN=CC=C4)O)C(=O)O
CHEMBL488224 adrb1_human Human No 6.3 EC50 = 480 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
461 10 3 6 2.2 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CN=CC=C4)O)C(=O)O
CHEMBL514094 adrb1_human Human No 6.3 EC50 = 480 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
453 7 4 6 1.8 C1CC2=C(CC1NCC(C3=CC(=CC=C3)Cl)O)C=C(C=C2)OC4=CC(=CC(=C4)N)C(=O)O
CHEMBL488224 adrb1_human Human No 6.3 EC50 = 480 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
461 10 3 6 2.2 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CN=CC=C4)O)C(=O)O
CHEMBL488224 adrb1_human Human No 6.3 EC50 = 480 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
461 10 3 6 2.2 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CN=CC=C4)O)C(=O)O
CHEMBL111201 adrb1_human Human No 5.3 EC50 = 4800 Funct
In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.In vitro functional efficacy in stimulating increase in cAMP in chinese hamster ovary (CHO) cells expressing the cloned human beta-1 receptor.
625 11 3 11 5.3 C1=CC(=CN=C1)C(CNCCC2=CC=C(C=C2)NS(=O)(=O)C3=CC=C(C=C3)C4=NC(=CS4)C5=CC=C(C=C5)C(F)(F)F)O
CHEMBL284311 adrb1_human Human No 4.3 EC50 = 48700 Funct
In vitro activity to increase cAMP levels in Chinese hamster ovary (CHO) cells expressing the cloned human beta 1 Adrenergic receptorIn vitro activity to increase cAMP levels in Chinese hamster ovary (CHO) cells expressing the cloned human beta 1 Adrenergic receptor
450 8 5 9 -1.1 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNC2CCN(CC2)C3=CC=C(C=C3)C(=O)O)O)O
CHEMBL100970 adrb1_human Human No 6.3 EC50 = 489 Funct
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
555 11 5 8 2.6 C1CN(CCC1CNCC(COC2=CC=C(C=C2)O)O)S(=O)(=O)C3=CC=C(C=C3)NC(=O)NC4=CC=CC=C4
CHEMBL186271 adrb1_human Human No 7.3 EC50 = 49 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
618 12 4 10 4.8 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C3=CC=CS3)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL186271 adrb1_human Human No 7.3 EC50 = 49 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
618 12 4 10 4.8 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C3=CC=CS3)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL551892 adrb1_human Human No 6.3 EC50 = 490 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
427 11 4 6 2.9 C1=CC(=CC=C1CCNCC(COC2=CC=C(C=C2)O)O)NC(=O)CC3=CSC=C3
CHEMBL498304 adrb1_human Human No 6.3 EC50 = 490 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
423 6 3 5 1.5 C1CC2=C(CC1NCC(C3=CC(=CC=C3)Cl)O)C=C(C=C2)C4=NC=C(C=C4)C(=O)O
CHEMBL551892 adrb1_human Human No 6.3 EC50 = 490 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
427 11 4 6 2.9 C1=CC(=CC=C1CCNCC(COC2=CC=C(C=C2)O)O)NC(=O)CC3=CSC=C3
CHEMBL498304 adrb1_human Human No 6.3 EC50 = 490 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
423 6 3 5 1.5 C1CC2=C(CC1NCC(C3=CC(=CC=C3)Cl)O)C=C(C=C2)C4=NC=C(C=C4)C(=O)O
CHEMBL565686 adrb1_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
433 7 4 5 3.4 CC(C)(CC1=CC=C(C=C1)C2=CC=CC=C2)NCC(C3=C4C(=C(C=C3)O)NC(=O)CO4)O
CHEMBL567833 adrb1_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
370 6 4 5 2.2 CC1=CC(=CC=C1)CC(C)(C)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL1258486 adrb1_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
384 7 2 7 3.2 C1CN(CCC1NCC(COC2=CC=CC=C2)O)C3=C4C=CSC4=NC=N3
CHEMBL565686 adrb1_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
433 7 4 5 3.4 CC(C)(CC1=CC=C(C=C1)C2=CC=CC=C2)NCC(C3=C4C(=C(C=C3)O)NC(=O)CO4)O
CHEMBL567833 adrb1_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
370 6 4 5 2.2 CC1=CC(=CC=C1)CC(C)(C)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL1258486 adrb1_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
384 7 2 7 3.2 C1CN(CCC1NCC(COC2=CC=CC=C2)O)C3=C4C=CSC4=NC=N3
CHEMBL153916 adrb1_human Human No 8.3 EC50 = 5.0 Funct
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
412 10 4 6 2.3 CC(CNC1=CC=C(C=C1)CNS(=O)(=O)C)NCC(C2=CC(=CC=C2)Cl)O
CHEMBL155072 adrb1_human Human No 8.3 EC50 = 5.0 Funct
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
305 7 3 3 3.4 CC(CNC1=CC=CC=C1)NCC(C2=CC(=CC=C2)Cl)O
CHEMBL576428 adrb1_human Human No 8.3 EC50 = 5.3 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
542 13 6 8 0.7 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCNC(=O)CN(C)C)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL576428 adrb1_human Human No 8.3 EC50 = 5.3 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
542 13 6 8 0.7 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCNC(=O)CN(C)C)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL567192 adrb1_human Human No 8.3 EC50 = 5.6 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
384 7 4 5 2.6 CCC1=CC=C(C=C1)CC(C)(C)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL186135 adrb1_human Human No 8.3 EC50 = 5.6 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
648 18 4 9 6.7 CCCCCCCCS(=O)(=O)OC1=CC=CC2=C1NC=C2CC(C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL567192 adrb1_human Human No 8.3 EC50 = 5.6 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
384 7 4 5 2.6 CCC1=CC=C(C=C1)CC(C)(C)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL570834 adrb1_human Human No 8.2 EC50 = 5.7 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
597 13 6 9 0.5 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCNC(=O)CN2CCN(CC2)C)NCC(C3=C4C(=C(C=C3)O)NC(=O)CO4)O
CHEMBL570834 adrb1_human Human No 8.2 EC50 = 5.7 Funct
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
597 13 6 9 0.5 CC(C)(CC1=CC=C(C=C1)NC(=O)CCCNC(=O)CN2CCN(CC2)C)NCC(C3=C4C(=C(C=C3)O)NC(=O)CO4)O
CHEMBL100351 adrb1_human Human No 7.3 EC50 = 50 Funct
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
643 11 5 11 -0.2 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNCC2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)N4C=CC5=C(C=CC=C54)C(=O)O)O)O
CHEMBL36568 adrb1_human Human No 7.3 EC50 = 50 Funct
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
507 10 6 10 -1.8 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNC2CCN(CC2)C3=CC=C(C=C3)C(=O)NCC(=O)O)O)O
CHEMBL467117 adrb1_human Human No 6.3 EC50 = 500 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
527 15 2 5 4.4 CCCN(C1=CC=C(C=C1)CCNCC(COC2=CC=CC=C2)O)C(=O)CC3=NC=CN3CC4=CC=CC=C4
CHEMBL510100 adrb1_human Human No 6.3 EC50 = 500 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
450 10 4 6 2.3 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNC(C)C(C3=CC=C(C=C3)O)O)C(=O)O
CHEMBL461282 adrb1_human Human No 6.3 EC50 = 500 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
454 10 3 5 2.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC=C(C=C3)Cl)O)C(=O)O
CHEMBL467117 adrb1_human Human No 6.3 EC50 = 500 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
527 15 2 5 4.4 CCCN(C1=CC=C(C=C1)CCNCC(COC2=CC=CC=C2)O)C(=O)CC3=NC=CN3CC4=CC=CC=C4
CHEMBL510100 adrb1_human Human No 6.3 EC50 = 500 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
450 10 4 6 2.3 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNC(C)C(C3=CC=C(C=C3)O)O)C(=O)O
CHEMBL461282 adrb1_human Human No 6.3 EC50 = 500 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
454 10 3 5 2.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC=C(C=C3)Cl)O)C(=O)O
CHEMBL358648 b0fl73_cavpo Guinea pig No 6.3 EC50 = 501.2 Funct
Inhibitory activity against Beta-1 adrenergic receptor in guinea pig atria after treatment with the compoundInhibitory activity against Beta-1 adrenergic receptor in guinea pig atria after treatment with the compound
381 5 3 8 2.7 COC1=CC(=CC(=C1OC)OC)CC2C3=C(CCN2)C(=C(C(=C3F)O)O)F
CHEMBL424866 adrb1_human Human No 5.3 EC50 = 5011.9 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
412 9 4 6 1.1 C1=CC(=CC(=C1)NCCNCC(C2=CC(=CC=C2)Cl)O)C3=NC(=CC=C3)C(=O)O
CHEMBL245874 adrb1_human Human No 5.3 EC50 = 5011.9 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
401 9 4 6 0.9 C1=CC(=CC(=C1)NCCNCC(C2=CC(=CC=C2)Cl)O)C3=C(C=CO3)C(=O)O
CHEMBL424866 adrb1_human Human No 5.3 EC50 = 5011.9 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
412 9 4 6 1.1 C1=CC(=CC(=C1)NCCNCC(C2=CC(=CC=C2)Cl)O)C3=NC(=CC=C3)C(=O)O
CHEMBL245874 adrb1_human Human No 5.3 EC50 = 5011.9 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
401 9 4 6 0.9 C1=CC(=CC(=C1)NCCNCC(C2=CC(=CC=C2)Cl)O)C3=C(C=CO3)C(=O)O
CHEMBL181115 adrb1_human Human No 7.3 EC50 = 51 Funct
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
402 12 5 5 2.1 CCCNC(=O)NC1=CC=C(C=C1)CC(CO)NCC(COC2=CC=CC=C2)O
CHEMBL489199 adrb1_human Human No 6.3 EC50 = 510 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
442 10 3 6 2.0 COC1=C(C=C(C=C1)OC2=CC=CC(=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL516785 adrb1_human Human No 6.3 EC50 = 510 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
436 11 3 6 2.0 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL489199 adrb1_human Human No 6.3 EC50 = 510 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
442 10 3 6 2.0 COC1=C(C=C(C=C1)OC2=CC=CC(=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL516785 adrb1_human Human No 6.3 EC50 = 510 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
436 11 3 6 2.0 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)OCCNCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL421030 adrb1_human Human No 6.3 EC50 = 511 Funct
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
429 10 5 6 1.9 C1CN(CCC1NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)C(=O)N
CHEMBL461301 adrb1_human Human No 7.3 EC50 = 52 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
510 11 3 6 3.6 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)OCCNCC(C4=CC(=CC=C4)Cl)O)C(=O)O
CHEMBL461301 adrb1_human Human No 7.3 EC50 = 52 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
510 11 3 6 3.6 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)OCCNCC(C4=CC(=CC=C4)Cl)O)C(=O)O
CHEMBL101674 adrb1_human Human No 6.3 EC50 = 520 Funct
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
690 14 7 12 -0.8 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNCC2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)NC(=O)NC(CC4=CC=CC=C4)C(=O)O)O)O
CHEMBL98088 adrb1_human Human No 6.3 EC50 = 520 Funct
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
611 13 6 10 0.4 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNCC2CCN(CC2)C3=CC=C(C=C3)C(=O)NC(CC4=CC=CC=C4)C(=O)O)O)O
CHEMBL107382 adrb1_human Human No 6.3 EC50 = 522 Funct
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
555 12 5 8 4.0 C1CN(CCC1NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)C(=O)NCC4=C(C=CC(=C4)F)F
CHEMBL317809 adrb1_human Human No 6.3 EC50 = 525 Funct
In vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptorIn vitro agonist activity measured by increase in cAMP levels in chinese hamster ovary cells (CHO) cells expressing human Beta-1 adrenergic receptor
623 12 5 11 2.9 C1CN(CCC1CNCC(COC2=CC(=C(C=C2)O)F)O)S(=O)(=O)C3=CC=C(C=C3)NC(=O)NCC4=C(C=CC(=C4)F)F
CHEMBL186676 adrb1_human Human No 7.3 EC50 = 54 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
562 12 4 7 5.2 CC(CC1=CNC2=C1C=CC=C2OCC3=CC=CC=C3)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL186676 adrb1_human Human No 7.3 EC50 = 54 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
562 12 4 7 5.2 CC(CC1=CNC2=C1C=CC=C2OCC3=CC=CC=C3)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL256418 adrb1_human Human No 7.3 EC50 = 55 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
494 10 3 5 3.9 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CC(=CC=C4)Cl)O)C(=O)O
CHEMBL256418 adrb1_human Human No 7.3 EC50 = 55 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
494 10 3 5 3.9 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CC(=CC=C4)Cl)O)C(=O)O
CHEMBL256418 adrb1_human Human No 7.3 EC50 = 55 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
494 10 3 5 3.9 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CC(=CC=C4)Cl)O)C(=O)O
CHEMBL256418 adrb1_human Human No 7.3 EC50 = 55 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
494 10 3 5 3.9 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CC(=CC=C4)Cl)O)C(=O)O
CHEMBL256418 adrb1_human Human No 7.3 EC50 = 55 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
494 10 3 5 3.9 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CC(=CC=C4)Cl)O)C(=O)O
CHEMBL256418 adrb1_human Human No 7.3 EC50 = 55 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
494 10 3 5 3.9 C1CCC(CC1)OC2=C(C=CC(=C2)C3=CC=C(C=C3)CCNCC(C4=CC(=CC=C4)Cl)O)C(=O)O
CHEMBL1682215 adrb1_rat Rat No 6.3 EC50 = 550 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
503 10 6 6 2.1 COC1=CC=CC=C1CNC(=O)NC2=CC=CC(=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O
CHEMBL489201 adrb1_human Human No 6.3 EC50 = 550 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
426 9 3 5 2.4 CC1=C(C=C(C=C1)OC2=CC=CC(=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL552434 adrb1_human Human No 6.3 EC50 = 550 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
460 11 4 6 2.4 C1=CC=C2C(=C1)C(C=N2)CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL539226 adrb1_human Human No 6.3 EC50 = 550 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
427 11 4 6 2.9 C1=CSC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL1682215 adrb1_rat Rat No 6.3 EC50 = 550 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
503 10 6 6 2.1 COC1=CC=CC=C1CNC(=O)NC2=CC=CC(=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O
CHEMBL489201 adrb1_human Human No 6.3 EC50 = 550 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
426 9 3 5 2.4 CC1=C(C=C(C=C1)OC2=CC=CC(=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL552434 adrb1_human Human No 6.3 EC50 = 550 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
460 11 4 6 2.4 C1=CC=C2C(=C1)C(C=N2)CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL539226 adrb1_human Human No 6.3 EC50 = 550 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
427 11 4 6 2.9 C1=CSC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL269920 adrb1_human Human No 6.2 EC50 = 570 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
410 8 3 4 2.5 CC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL269920 adrb1_human Human No 6.2 EC50 = 570 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
410 8 3 4 2.5 CC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL1682219 adrb1_rat Rat No 5.2 EC50 = 5770 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
535 9 6 5 3.8 C1=CC=C(C=C1)C2=CC=CC=C2NC(=O)NC3=CC=CC(=C3)CCNCC(C4=C5C=CC(=O)NC5=C(C=C4)O)O
CHEMBL1682219 adrb1_rat Rat No 5.2 EC50 = 5770 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
535 9 6 5 3.8 C1=CC=C(C=C1)C2=CC=CC=C2NC(=O)NC3=CC=CC(=C3)CCNCC(C4=C5C=CC(=O)NC5=C(C=C4)O)O
CHEMBL186236 adrb1_human Human No 7.2 EC50 = 58 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
684 15 4 11 5.0 CCOC(=O)C1=CC=C(C=C1)S(=O)(=O)OC2=CC=CC3=C2NC=C3CC(C)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL186236 adrb1_human Human No 7.2 EC50 = 58 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
684 15 4 11 5.0 CCOC(=O)C1=CC=C(C=C1)S(=O)(=O)OC2=CC=CC3=C2NC=C3CC(C)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL248547 adrb1_human Human No 7.2 EC50 = 58.3 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levelAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP level
517 11 4 7 2.3 CC(C)(CC1=CC=C(C=C1)OC2=NC=C(C=C2)C(=O)N)NCC(COC3=CC=CC4=C3C5(CC5)C(=O)N4)O
CHEMBL248547 adrb1_human Human No 7.2 EC50 = 58.3 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP levelAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP level
517 11 4 7 2.3 CC(C)(CC1=CC=C(C=C1)OC2=NC=C(C=C2)C(=O)N)NCC(COC3=CC=CC4=C3C5(CC5)C(=O)N4)O
CHEMBL101521 adrb1_human Human No 6.2 EC50 = 580 Funct
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
579 13 7 12 -2.1 CS(=O)(=O)NC1=C(C=CC(=C1)C(CNCC2CCN(CC2)C3=CC=C(C=C3)C(=O)NC(CC(=O)O)C(=O)O)O)O
CHEMBL551832 adrb1_human Human No 6.2 EC50 = 590 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
437 11 5 6 2.7 C1=CC=C(C=C1)C(C(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)O
CHEMBL551832 adrb1_human Human No 6.2 EC50 = 590 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
437 11 5 6 2.7 C1=CC=C(C=C1)C(C(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)O
CHEMBL185660 adrb1_human Human No 8.2 EC50 = 6.2 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
578 12 4 9 4.0 CC(C)S(=O)(=O)OC1=CC=CC2=C1NC=C2CC(C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL1257916 adrb1_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
495 8 3 9 4.6 C1CN(CCC1NCC(COC2=CC=C(C=C2)O)O)C3=C4C(=CSC4=NC=N3)C5=CC=C(C=C5)F
CHEMBL1257916 adrb1_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
495 8 3 9 4.6 C1CN(CCC1NCC(COC2=CC=C(C=C2)O)O)C3=C4C(=CSC4=NC=N3)C5=CC=C(C=C5)F
CHEMBL205224 adrb1_human Human No 8.2 EC50 = 6.3 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
425 9 4 5 2.3 CC(CNC1=CC=CC(=C1)C2=CC(=CC=C2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL3298213 adrb1_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
479 12 6 7 2.6 CC(C)(COC1=CC=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NC=O)O)N
CHEMBL3298986 adrb1_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
503 11 6 7 2.8 CC(C)(COC1=CC=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)N
CHEMBL205224 adrb1_human Human No 8.2 EC50 = 6.3 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
425 9 4 5 2.3 CC(CNC1=CC=CC(=C1)C2=CC(=CC=C2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL3298213 adrb1_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
479 12 6 7 2.6 CC(C)(COC1=CC=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NC=O)O)N
CHEMBL3298986 adrb1_human Human No 8.2 EC50 = 6.3 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
503 11 6 7 2.8 CC(C)(COC1=CC=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)N
CHEMBL282190 adrb1_human Human No 8.2 EC50 = 6.4 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
403 9 4 5 1.1 CC(CC1=CNC2=C1C=CC=C2OCC(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL279260 adrb1_human Human Yes 8.2 EC50 = 6.4 Funct
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
403 9 4 5 1.1 CC(CC1=CNC2=C1C=CC=C2OCC(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL270460 adrb1_human Human No 8.2 EC50 = 6.5 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
426 9 3 5 2.1 COC1=C(C=CC(=C1)CCNCC(C2=CC(=CC=C2)Cl)O)C3=CC=C(C=C3)C(=O)O
CHEMBL270460 adrb1_human Human No 8.2 EC50 = 6.5 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
426 9 3 5 2.1 COC1=C(C=CC(=C1)CCNCC(C2=CC(=CC=C2)Cl)O)C3=CC=C(C=C3)C(=O)O
CHEMBL1257915 adrb1_human Human No 8.2 EC50 = 6.6 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
479 8 2 8 4.9 C1CN(CCC1NCC(COC2=CC=CC=C2)O)C3=C4C(=CSC4=NC=N3)C5=CC=C(C=C5)F
CHEMBL186676 adrb1_human Human No 8.2 EC50 = 6.6 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
562 12 4 7 5.2 CC(CC1=CNC2=C1C=CC=C2OCC3=CC=CC=C3)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL361505 adrb1_human Human No 8.2 EC50 = 6.6 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
486 10 4 7 3.7 CC(CC1=CNC2=C1C=CC=C2OC)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL1257915 adrb1_human Human No 8.2 EC50 = 6.6 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
479 8 2 8 4.9 C1CN(CCC1NCC(COC2=CC=CC=C2)O)C3=C4C(=CSC4=NC=N3)C5=CC=C(C=C5)F
CHEMBL576848 adrb1_human Human No 8.2 EC50 = 6.7 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
399 7 4 5 2.9 CC(C)C1=CC=C(C=C1)CC(C)(C)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL576848 adrb1_human Human No 8.2 EC50 = 6.7 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
399 7 4 5 2.9 CC(C)C1=CC=C(C=C1)CC(C)(C)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL2261203 adrb1_human Human No 8.2 EC50 = 6.8 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
585 14 4 8 3.9 CCN(CC)C(=O)COC1=CC=CC2=C1NC=C2CC(C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL285881 adrb1_human Human Yes 7.2 EC50 = 60 Funct
Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptorIncreased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 1 Adrenergic receptor
563 12 6 10 -0.1 CC(C)CC(C(=O)O)NC(=O)C1=CC=C(C=C1)N2CCC(CC2)NCC(C3=CC(=C(C=C3)O)NS(=O)(=O)C)O
CHEMBL564556 adrb1_human Human No 6.2 EC50 = 600 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
471 11 4 5 4.5 C1=CC=C2C(=C1)C=CC=C2CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL1258257 adrb1_human Human No 6.2 EC50 = 600 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
479 8 2 8 4.9 C1CN(CCC1NCC(COC2=CC=CC=C2F)O)C3=C4C(=CSC4=NC=N3)C5=CC=CC=C5
CHEMBL564556 adrb1_human Human No 6.2 EC50 = 600 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
471 11 4 5 4.5 C1=CC=C2C(=C1)C=CC=C2CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=C(C=C4)O)O
CHEMBL1258257 adrb1_human Human No 6.2 EC50 = 600 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
479 8 2 8 4.9 C1CN(CCC1NCC(COC2=CC=CC=C2F)O)C3=C4C(=CSC4=NC=N3)C5=CC=CC=C5
CHEMBL2092996 b0fl73_cavpo Guinea pig No 5.2 EC50 = 6025.6 Funct
Inhibitory activity against Beta-1 adrenergic receptor in guinea pig atriaInhibitory activity against Beta-1 adrenergic receptor in guinea pig atria
363 5 3 7 2.6 COC1=CC(=CC(=C1OC)OC)CC2C3=C(C(=C(C=C3CCN2)O)O)F
CHEMBL106022 adrb1_human Human No 6.2 EC50 = 610 Funct
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
541 17 5 6 5.7 CCCCCCCCNC(=O)N1CCC(CC1)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL421871 adrb1_human Human No 5.2 EC50 = 6100 Funct
Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)Compound was evaluated for its inhibitory activity against human beta-1 adrenergic receptor (AR)
421 6 3 6 4.1 COC1=CC(=CC(=C1OC)OC)C2=CC=C(C=C2)CC3C4=CC(=C(C=C4CCN3)O)O
CHEMBL466088 adrb1_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
499 13 3 5 3.7 CC(CC1=CC=C(C=C1)NC(=O)CC2=NC=CN2CC3=CC=CC=C3)NCC(COC4=CC=CC=C4)O
CHEMBL488051 adrb1_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
420 10 3 5 2.2 CCOC1=C(C=CC(=C1)C2=CC=C(C=C2)CC(C)NCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL466088 adrb1_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
499 13 3 5 3.7 CC(CC1=CC=C(C=C1)NC(=O)CC2=NC=CN2CC3=CC=CC=C3)NCC(COC4=CC=CC=C4)O
CHEMBL488051 adrb1_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
420 10 3 5 2.2 CCOC1=C(C=CC(=C1)C2=CC=C(C=C2)CC(C)NCC(C3=CC=CC=C3)O)C(=O)O
CHEMBL491645 adrb1_human Human No 6.2 EC50 = 620 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
511 11 4 6 3.1 CC(C)(C)C(=O)NC1=C(C=C(C=C1)OC2=CC=CC(=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL450842 adrb1_human Human No 6.2 EC50 = 620 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
422 6 3 4 2.6 C1CC2=C(CC1NCC(C3=CC=CC=C3Cl)O)C=C(C=C2)C4=CC=C(C=C4)C(=O)O
CHEMBL491645 adrb1_human Human No 6.2 EC50 = 620 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
511 11 4 6 3.1 CC(C)(C)C(=O)NC1=C(C=C(C=C1)OC2=CC=CC(=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL450842 adrb1_human Human No 6.2 EC50 = 620 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
422 6 3 4 2.6 C1CC2=C(CC1NCC(C3=CC=CC=C3Cl)O)C=C(C=C2)C4=CC=C(C=C4)C(=O)O
CHEMBL273028 adrb1_human Human No 7.2 EC50 = 63 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
410 8 3 4 2.5 CC1=C(C=CC(=C1)C(=O)O)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL273028 adrb1_human Human No 7.2 EC50 = 63 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
410 8 3 4 2.5 CC1=C(C=CC(=C1)C(=O)O)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL1807871 adrb1_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
516 13 5 7 3.8 C1=CC(=C(C(=C1)Cl)Cl)CCNCCSCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1945039 adrb1_human Human No 7.2 EC50 = 63.1 Funct
Binding affinity to beta1 adrenoceptor expressed in CHO cells by cAMP accumulation assayBinding affinity to beta1 adrenoceptor expressed in CHO cells by cAMP accumulation assay
480 11 5 7 2.8 COC1=CC=CC=C1CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL1807871 adrb1_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at adrenergic beta1 receptorAgonist activity at adrenergic beta1 receptor
516 13 5 7 3.8 C1=CC(=C(C(=C1)Cl)Cl)CCNCCSCCCNCC(C2=C3C(=C(C=C2)O)NC(=O)S3)O
CHEMBL1945039 adrb1_human Human No 7.2 EC50 = 63.1 Funct
Binding affinity to beta1 adrenoceptor expressed in CHO cells by cAMP accumulation assayBinding affinity to beta1 adrenoceptor expressed in CHO cells by cAMP accumulation assay
480 11 5 7 2.8 COC1=CC=CC=C1CNCC2=CC=CC(=C2)CCNCC(C3=C4C(=C(C=C3)O)NC(=O)S4)O
CHEMBL377028 adrb1_human Human No 6.2 EC50 = 631.0 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
425 9 4 5 2.3 CC(CNC1=CC=CC(=C1)C2=CC=CC=C2C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL348501 adrb1_human Human No 6.2 EC50 = 631.0 Funct
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
516 11 4 6 4.1 CC1=CC=C(C=C1)S(=O)(=O)NC(=O)CC2=CC=C(C=C2)NCC(C)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL155092 adrb1_human Human No 6.2 EC50 = 631.0 Funct
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
349 8 4 5 0.6 CC(CNC1=CC=C(C=C1)C(=O)O)NCC(C2=CC(=CC=C2)Cl)O
CHEMBL377028 adrb1_human Human No 6.2 EC50 = 631.0 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
425 9 4 5 2.3 CC(CNC1=CC=CC(=C1)C2=CC=CC=C2C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL1682216 adrb1_rat Rat No 5.2 EC50 = 6300 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
491 9 6 6 2.3 C1=CC(=CC(=C1)NC(=O)NCC2=CC=C(C=C2)F)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O
CHEMBL1682216 adrb1_rat Rat No 5.2 EC50 = 6300 Funct
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effectAgonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
491 9 6 6 2.3 C1=CC(=CC(=C1)NC(=O)NCC2=CC=C(C=C2)F)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O
CHEMBL100589 adrb1_human Human No 5.2 EC50 = 6300 Funct
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
710 13 5 12 2.5 CC(C)N(CC1=C(C=CC(=C1)F)F)C(=O)NC2=CC=C(C=C2)S(=O)(=O)N3CCC(CC3)CNCC(C4=CC(=C(C=C4)O)NS(=O)(=O)C)O
CHEMBL270027 adrb1_human Human No 7.2 EC50 = 64 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
440 11 3 5 2.4 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)CC3=CC=C(C=C3)OCC(=O)O)O
CHEMBL484265 adrb1_human Human No 7.2 EC50 = 64 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
446 9 3 5 2.6 C1=CC(=CC(=C1)OC2=CC(=C(C=C2)Cl)C(=O)O)CCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL270027 adrb1_human Human No 7.2 EC50 = 64 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
440 11 3 5 2.4 C1=CC(=CC(=C1)Cl)C(CNCCC2=CC=C(C=C2)CC3=CC=C(C=C3)OCC(=O)O)O
CHEMBL484265 adrb1_human Human No 7.2 EC50 = 64 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
446 9 3 5 2.6 C1=CC(=CC(=C1)OC2=CC(=C(C=C2)Cl)C(=O)O)CCNCC(C3=CC(=CC=C3)Cl)O
CHEMBL568060 adrb1_human Human No 6.2 EC50 = 645 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
389 6 3 5 4.0 CC(C)(CC1=CC(=CC(=C1)F)F)NCC(C2=CC(=C(C(=C2)Cl)N)Cl)O
CHEMBL568060 adrb1_human Human No 6.2 EC50 = 645 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
389 6 3 5 4.0 CC(C)(CC1=CC(=CC(=C1)F)F)NCC(C2=CC(=C(C(=C2)Cl)N)Cl)O
CHEMBL1258373 adrb1_human Human No 7.2 EC50 = 65 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
415 7 3 8 3.2 CC1=CSC2=NC=NC(=C12)N3CCC(CC3)NCC(COC4=CC=C(C=C4)O)O
CHEMBL1258373 adrb1_human Human No 7.2 EC50 = 65 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
415 7 3 8 3.2 CC1=CSC2=NC=NC(=C12)N3CCC(CC3)NCC(COC4=CC=C(C=C4)O)O
CHEMBL467082 adrb1_human Human No 6.2 EC50 = 650 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
471 12 3 5 3.4 C1=CC=C(C=C1)N2C=CN=C2CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=CC=C4)O
CHEMBL457629 adrb1_human Human No 6.2 EC50 = 650 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
440 6 3 5 2.7 C1CC2=C(CC1NCC(C3=CC=C(C=C3)Cl)O)C=C(C=C2)C4=CC(=C(C=C4)C(=O)O)F
CHEMBL467082 adrb1_human Human No 6.2 EC50 = 650 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
471 12 3 5 3.4 C1=CC=C(C=C1)N2C=CN=C2CC(=O)NC3=CC=C(C=C3)CCNCC(COC4=CC=CC=C4)O
CHEMBL457629 adrb1_human Human No 6.2 EC50 = 650 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
440 6 3 5 2.7 C1CC2=C(CC1NCC(C3=CC=C(C=C3)Cl)O)C=C(C=C2)C4=CC(=C(C=C4)C(=O)O)F
CHEMBL185836 adrb1_human Human No 7.2 EC50 = 66 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
456 9 4 6 3.7 CC(CC1=CNC2=CC=CC=C21)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL185836 adrb1_human Human No 7.2 EC50 = 66 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
456 9 4 6 3.7 CC(CC1=CNC2=CC=CC=C21)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL550743 adrb1_human Human No 6.2 EC50 = 660 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
436 11 5 6 2.4 C1=CC=C(C=C1)C(C(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)N
CHEMBL550743 adrb1_human Human No 6.2 EC50 = 660 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
436 11 5 6 2.4 C1=CC=C(C=C1)C(C(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)N
CHEMBL497280 adrb1_human Human No 6.2 EC50 = 670 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
444 7 3 6 2.8 C1CC2=C(CC1NCC(C3=CC(=CC=C3)Cl)O)C=C(C=C2)OC4=CC=C(S4)C(=O)O
CHEMBL497280 adrb1_human Human No 6.2 EC50 = 670 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
444 7 3 6 2.8 C1CC2=C(CC1NCC(C3=CC(=CC=C3)Cl)O)C=C(C=C2)OC4=CC=C(S4)C(=O)O
CHEMBL509729 adrb1_human Human No 7.2 EC50 = 69 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
535 9 4 6 4.3 C1CCC(CC1)NC2=CC(=CC(=C2)C(=O)O)OC3=CC4=C(CCC(C4)NCC(C5=CC(=CC=C5)Cl)O)C=C3
CHEMBL2260987 adrb1_human Human No 7.2 EC50 = 69 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
508 10 4 6 3.5 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C)NCC(C3=CC=C(C=C3)C(=O)NC4=CC=CC=C4)O
CHEMBL509729 adrb1_human Human No 7.2 EC50 = 69 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
535 9 4 6 4.3 C1CCC(CC1)NC2=CC(=CC(=C2)C(=O)O)OC3=CC4=C(CCC(C4)NCC(C5=CC(=CC=C5)Cl)O)C=C3
CHEMBL490415 adrb1_human Human No 6.2 EC50 = 690 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
408 10 3 7 0.3 COC1=C(C=C(C=C1)OC2=CC=CC(=C2)CCNCC(C3=CN=CC=C3)O)C(=O)O
CHEMBL453048 adrb1_human Human No 6.2 EC50 = 690 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
434 11 3 5 2.8 CCCOC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNC(C)C(C3=CC=CC=C3)O)C(=O)O
CHEMBL490415 adrb1_human Human No 6.2 EC50 = 690 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
408 10 3 7 0.3 COC1=C(C=C(C=C1)OC2=CC=CC(=C2)CCNCC(C3=CN=CC=C3)O)C(=O)O
CHEMBL453048 adrb1_human Human No 6.2 EC50 = 690 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
434 11 3 5 2.8 CCCOC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNC(C)C(C3=CC=CC=C3)O)C(=O)O
CHEMBL566353 adrb1_human Human No 6.2 EC50 = 695 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
381 7 3 3 4.6 CCC1=CC=C(C=C1)CC(C)(C)NCC(C2=CC(=C(C(=C2)Cl)N)Cl)O
CHEMBL566353 adrb1_human Human No 6.2 EC50 = 695 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
381 7 3 3 4.6 CCC1=CC=C(C=C1)CC(C)(C)NCC(C2=CC(=C(C(=C2)Cl)N)Cl)O
CHEMBL565267 adrb1_human Human No 8.1 EC50 = 7.2 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
392 6 4 7 2.0 CC(C)(CC1=CC(=CC(=C1)F)F)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL2260984 adrb1_human Human No 8.1 EC50 = 7.2 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
608 14 4 11 3.8 CCOC(=O)S(=O)(=O)OC1=CC=CC2=C1NC=C2CC(C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL565267 adrb1_human Human No 8.1 EC50 = 7.2 Funct
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
392 6 4 7 2.0 CC(C)(CC1=CC(=CC(=C1)F)F)NCC(C2=C3C(=C(C=C2)O)NC(=O)CO3)O
CHEMBL187317 adrb1_human Human No 8.1 EC50 = 7.3 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
592 14 4 9 4.5 CCCCS(=O)(=O)OC1=CC=CC2=C1NC=C2CC(C)NCC(C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4)O
CHEMBL1374751 adrb1_human Human Yes 8.1 EC50 = 7.4 Funct
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
219 4 3 4 1.7 CC(C)NCC(C1=CC(=C(C=C1)N)C#N)O
CHEMBL183552 adrb1_human Human No 8.1 EC50 = 7.6 Funct
Agonist activity at Homo sapiens (human) beta1 adrenoreceptorAgonist activity at Homo sapiens (human) beta1 adrenoreceptor
544 11 4 6 5.4 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C)NCC(C3=CC(=CC=C3)NCC4=CC5=CC=CC=C5C=C4)O
CHEMBL345304 adrb1_human Human No 8.1 EC50 = 7.9 Funct
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
376 9 4 4 2.5 CC(CNC1=CC=C(C=C1)CNC(=O)C)NCC(C2=CC(=CC=C2)Cl)O
CHEMBL3290999 adrb1_human Human Yes 8.1 EC50 = 7.9 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
522 10 5 6 4.8 COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)C5=CC=CC=C5
CHEMBL3298330 adrb1_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
503 13 6 7 2.9 C1=CC(=CC=C1CCNCC(C2=C3C=CC(=O)NC3=C(C=C2)O)O)NC4=CC=C(C=C4)OCCCCN
CHEMBL3298832 adrb1_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
622 13 5 10 2.3 CS(=O)(=O)N1CCN(CC1)CCOC2=CC=C(C=C2)NC3=CC=C(C=C3)CCNCC(C4=C5C=CC(=O)NC5=C(C=C4)O)O
CHEMBL3298328 adrb1_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
475 11 6 7 2.2 C1=CC(=CC=C1CCNCC(C2=C3C=CC(=O)NC3=C(C=C2)O)O)NC4=CC=C(C=C4)OCCN
CHEMBL3298691 adrb1_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
519 14 6 8 2.1 C1=CC(=CC=C1CCNCC(C2=C3C=CC(=O)NC3=C(C=C2)O)O)NC4=CC=C(C=C4)OCCOCCN
CHEMBL3298329 adrb1_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
489 12 6 7 2.6 C1=CC(=CC=C1CCNCC(C2=C3C=CC(=O)NC3=C(C=C2)O)O)NC4=CC=C(C=C4)OCCCN
CHEMBL3290999 adrb1_human Human Yes 8.1 EC50 = 7.9 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
522 10 5 6 4.8 COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)C5=CC=CC=C5
CHEMBL3298330 adrb1_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
503 13 6 7 2.9 C1=CC(=CC=C1CCNCC(C2=C3C=CC(=O)NC3=C(C=C2)O)O)NC4=CC=C(C=C4)OCCCCN
CHEMBL3298832 adrb1_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
622 13 5 10 2.3 CS(=O)(=O)N1CCN(CC1)CCOC2=CC=C(C=C2)NC3=CC=C(C=C3)CCNCC(C4=C5C=CC(=O)NC5=C(C=C4)O)O
CHEMBL3298328 adrb1_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
475 11 6 7 2.2 C1=CC(=CC=C1CCNCC(C2=C3C=CC(=O)NC3=C(C=C2)O)O)NC4=CC=C(C=C4)OCCN
CHEMBL3298691 adrb1_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
519 14 6 8 2.1 C1=CC(=CC=C1CCNCC(C2=C3C=CC(=O)NC3=C(C=C2)O)O)NC4=CC=C(C=C4)OCCOCCN
CHEMBL3298329 adrb1_human Human No 8.1 EC50 = 7.9 Funct
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
489 12 6 7 2.6 C1=CC(=CC=C1CCNCC(C2=C3C=CC(=O)NC3=C(C=C2)O)O)NC4=CC=C(C=C4)OCCCN
CHEMBL3290999 adrb1_human Human Yes 8.1 EC50 = 7.9 Funct
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
522 10 5 6 4.8 COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)C5=CC=CC=C5
CHEMBL3290999 adrb1_human Human Yes 8.1 EC50 = 7.9 Funct
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
522 10 5 6 4.8 COC1=C(C=C(C=C1)NC2=CC=C(C=C2)CCNCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)C5=CC=CC=C5
CHEMBL498703 adrb1_human Human No 7.2 EC50 = 70 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
439 7 3 6 1.7 C1CC2=C(CC1NCC(C3=CC(=CC=C3)Cl)O)C=C(C=C2)OC4=NC=C(C=C4)C(=O)O
CHEMBL1258371 adrb1_human Human No 7.2 EC50 = 70 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
491 9 3 8 3.9 C1CN(CCC1NCC(COC2=CC=CC(=C2)CO)O)C3=C4C(=CSC4=NC=N3)C5=CC=CC=C5
CHEMBL498703 adrb1_human Human No 7.2 EC50 = 70 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
439 7 3 6 1.7 C1CC2=C(CC1NCC(C3=CC(=CC=C3)Cl)O)C=C(C=C2)OC4=NC=C(C=C4)C(=O)O
CHEMBL1258371 adrb1_human Human No 7.2 EC50 = 70 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
491 9 3 8 3.9 C1CN(CCC1NCC(COC2=CC=CC(=C2)CO)O)C3=C4C(=CSC4=NC=N3)C5=CC=CC=C5
CHEMBL561211 adrb1_human Human No 6.2 EC50 = 710 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
451 12 4 6 3.2 COC1=CC=CC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL561211 adrb1_human Human No 6.2 EC50 = 710 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
451 12 4 6 3.2 COC1=CC=CC(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL601430 adrb1_human Human No 6.2 EC50 = 711.5 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
424 6 4 8 2.7 CC(C)(CC1=CC=C(C=C1)C(F)(F)F)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL601430 adrb1_human Human No 6.2 EC50 = 711.5 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
424 6 4 8 2.7 CC(C)(CC1=CC=C(C=C1)C(F)(F)F)NCC(C2=CC(=CC3=C2OCC(=O)N3)O)O
CHEMBL187209 adrb1_human Human No 7.1 EC50 = 72 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
612 12 4 9 4.8 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C3=CC=CC=C3)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL187209 adrb1_human Human No 7.1 EC50 = 72 Funct
Agonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptorAgonistic activity was determined by measuring cAMP accumulation in CHO cells expressing cloned human Beta-1 adrenergic receptor
612 12 4 9 4.8 CC(CC1=CNC2=C1C=CC=C2OS(=O)(=O)C3=CC=CC=C3)NCC(C4=CC(=CC=C4)NS(=O)(=O)C5=CC=CS5)O
CHEMBL272584 adrb1_human Human No 6.1 EC50 = 720 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
454 10 3 5 2.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL272584 adrb1_human Human No 6.1 EC50 = 720 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
454 10 3 5 2.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL564544 adrb1_human Human No 6.1 EC50 = 720 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
455 11 4 5 3.8 C1=CC=C(C(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)Cl
CHEMBL272584 adrb1_human Human No 6.1 EC50 = 720 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
454 10 3 5 2.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL272584 adrb1_human Human No 6.1 EC50 = 720 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
454 10 3 5 2.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL272584 adrb1_human Human No 6.1 EC50 = 720 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
454 10 3 5 2.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL272584 adrb1_human Human No 6.1 EC50 = 720 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
454 10 3 5 2.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL564544 adrb1_human Human No 6.1 EC50 = 720 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
455 11 4 5 3.8 C1=CC=C(C(=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)Cl
CHEMBL272584 adrb1_human Human No 6.1 EC50 = 720 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
454 10 3 5 2.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL272584 adrb1_human Human No 6.1 EC50 = 720 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
454 10 3 5 2.9 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNCC(C3=CC(=CC=C3)Cl)O)C(=O)O
CHEMBL530556 adrb1_human Human No 5.1 EC50 = 7282 Funct
Agonist activity at adrenergic beta-1 receptorAgonist activity at adrenergic beta-1 receptor
447 11 2 5 4.8 COC1=CC=C(C=C1)CCNCC(COC2=CC3=C(C=C2)N(CCC3)CC4=CC=CC=C4)O
CHEMBL530556 adrb1_human Human No 5.1 EC50 = 7282 Funct
Agonist activity at adrenergic beta-1 receptorAgonist activity at adrenergic beta-1 receptor
447 11 2 5 4.8 COC1=CC=C(C=C1)CCNCC(COC2=CC3=C(C=C2)N(CCC3)CC4=CC=CC=C4)O
CHEMBL551532 adrb1_human Human No 7.1 EC50 = 73 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
509 11 3 5 5.1 CC(C)CC1=C(C=CC(=C1)C2=CC=C(C=C2)CC(C)NCC(C3=CC=CC=C3)O)C(=O)NS(=O)(=O)C
CHEMBL551532 adrb1_human Human No 7.1 EC50 = 73 Funct
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay
509 11 3 5 5.1 CC(C)CC1=C(C=CC(=C1)C2=CC=C(C=C2)CC(C)NCC(C3=CC=CC=C3)O)C(=O)NS(=O)(=O)C
CHEMBL99599 adrb1_human Human No 6.1 EC50 = 730 Funct
Beta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptorBeta-1 adrenergic receptor agonist activity as increased cAMP levels in CHO cells expressing human Beta-1-adrenoceptor
639 17 5 10 3.6 CCCCCCCCC(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCC(CC2)CNCC(C3=CC(=C(C=C3)O)NS(=O)(=O)C)O
CHEMBL510102 adrb1_human Human No 7.1 EC50 = 75 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
376 8 3 5 0.8 CC(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O)NCC(C3=CN=CC=C3)O
CHEMBL510102 adrb1_human Human No 7.1 EC50 = 75 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
376 8 3 5 0.8 CC(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O)NCC(C3=CN=CC=C3)O
CHEMBL106884 adrb1_human Human No 6.1 EC50 = 750 Funct
In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptorIn vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor
555 12 5 8 4.0 C1CN(CCC1NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O)C(=O)NCC4=C(C=CC=C4F)F
CHEMBL550746 adrb1_human Human No 6.1 EC50 = 760 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
421 11 4 5 3.2 C1=CC=C(C=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL550746 adrb1_human Human No 6.1 EC50 = 760 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
421 11 4 5 3.2 C1=CC=C(C=C1)CC(=O)NC2=CC=C(C=C2)CCNCC(COC3=CC=C(C=C3)O)O
CHEMBL457839 adrb1_human Human No 6.1 EC50 = 775 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
455 6 3 7 2.8 C1CC2=C(CC1NCC(C3=CC=C(C=C3)C(F)(F)F)O)C=C(C=C2)C4=CC=C(C=C4)C(=O)O
CHEMBL457839 adrb1_human Human No 6.1 EC50 = 775 Funct
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
455 6 3 7 2.8 C1CC2=C(CC1NCC(C3=CC=C(C=C3)C(F)(F)F)O)C=C(C=C2)C4=CC=C(C=C4)C(=O)O
CHEMBL453047 adrb1_human Human No 6.1 EC50 = 780 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
434 10 3 5 2.7 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNC(C)C(C3=CC=CC=C3)O)C(=O)O
CHEMBL453047 adrb1_human Human No 6.1 EC50 = 780 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
434 10 3 5 2.7 CC(C)OC1=C(C=CC(=C1)C2=CC=C(C=C2)CCNC(C)C(C3=CC=CC=C3)O)C(=O)O
CHEMBL563872 adrb1_human Human No 4.1 EC50 = 78000 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
427 11 3 6 3.3 C1=CC=C(C=C1)OCC(CNCCC2=CC=C(C=C2)NS(=O)(=O)C3=CC=CC=C3)O
CHEMBL563872 adrb1_human Human No 4.1 EC50 = 78000 Funct
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassayAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay
427 11 3 6 3.3 C1=CC=C(C=C1)OCC(CNCCC2=CC=C(C=C2)NS(=O)(=O)C3=CC=CC=C3)O
CHEMBL154419 adrb1_human Human No 7.1 EC50 = 79.4 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
363 9 4 5 0.6 CC(CNC1=CC=C(C=C1)CC(=O)O)NCC(C2=CC(=CC=C2)Cl)O
CHEMBL247315 adrb1_human Human No 7.1 EC50 = 79.4 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
432 9 4 7 1.7 CC(CNC1=CC=CC(=C1)C2=NC(=CS2)C(=O)O)NCC(C3=CC(=CC=C3)Cl)O
CHEMBL154419 adrb1_human Human No 7.1 EC50 = 79.4 Funct
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
363 9 4 5 0.6 CC(CNC1=CC=C(C=C1)CC(=O)O)NCC(C2=CC(=CC=C2)Cl)O
CHEMBL1086535 adrb1_human Human No 7.1 EC50 = 79.4 Funct
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
434 16 5 7 2.2 C1=CC(=CC=C1COCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O)O
CHEMBL154419 adrb1_human Human No 7.1 EC50 = 79.4 Funct
Ability to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentrationAbility to cause cAMP accumulation in CHO cells expressing human beta-1 AR expressed as the negative logarithm of the molar drug concentration
363 9 4 5 0.6 CC(CNC1=CC=C(C=C1)CC(=O)O)NCC(C2=CC(=CC=C2)Cl)O
CHEMBL154419 adrb1_human Human No 7.1 EC50 = 79.4 Funct
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulati