Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name
GPCRdb
ID
Reference
ligand
Vendors

Species

Assay
Type

Activity
Type
Activity
Relation
Activity
Value
p-value
(-log)
Fold
selectivity
Tested
GPCRs
Assay
Description
Source

Mol
weight
Rot
Bonds
H don

H acc

LogP

Smiles

DOI

2583 205892 None 51 Human Functional pAC50 = 9 9.0 6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 292 5 3 4 1.7 CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2 10.1038/s41467-023-40064-9
CHEMBL839 205892 None 51 Human Functional pAC50 = 9 9.0 6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 292 5 3 4 1.7 CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2 10.1038/s41467-023-40064-9
DB00521 205892 None 51 Human Functional pAC50 = 9 9.0 6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 292 5 3 4 1.7 CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2 10.1038/s41467-023-40064-9
1978 250 None 60 Human Functional pAC50 = 6 6.0 28 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 336 10 3 5 3.0 CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O 10.1038/s41467-023-40064-9
40 250 None 60 Human Functional pAC50 = 6 6.0 28 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 336 10 3 5 3.0 CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O 10.1038/s41467-023-40064-9
7107 250 None 60 Human Functional pAC50 = 6 6.0 28 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 336 10 3 5 3.0 CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O 10.1038/s41467-023-40064-9
CHEMBL642 250 None 60 Human Functional pAC50 = 6 6.0 28 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 336 10 3 5 3.0 CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O 10.1038/s41467-023-40064-9
DB01193 250 None 60 Human Functional pAC50 = 6 6.0 28 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 336 10 3 5 3.0 CCCC(=Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O)O 10.1038/s41467-023-40064-9
10184665 3989 None 51 Human Functional pAC50 = 5 5.0 -173 10
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
4799 3989 None 51 Human Functional pAC50 = 5 5.0 -173 10
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
7353 3989 None 51 Human Functional pAC50 = 5 5.0 -173 10
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
CHEMBL1198857 3989 None 51 Human Functional pAC50 = 5 5.0 -173 10
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
DB09082 3989 None 51 Human Functional pAC50 = 5 5.0 -173 10
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
216416 111579 None 48 Human Functional pAC50 = 5 5.0 -117 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
CHEMBL328190 111579 None 48 Human Functional pAC50 = 5 5.0 -117 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
11823027 192614 None 37 Human Functional pAC50 = 7.0 7.0 -5 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 309 5 4 5 0.6 CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2 10.1038/s41467-023-40064-9
4411 192614 None 37 Human Functional pAC50 = 7.0 7.0 -5 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 309 5 4 5 0.6 CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2 10.1038/s41467-023-40064-9
CHEMBL3246778 192614 None 37 Human Functional pAC50 = 7.0 7.0 -5 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 309 5 4 5 0.6 CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2 10.1038/s41467-023-40064-9
CHEMBL521606 192614 None 37 Human Functional pAC50 = 7.0 7.0 -5 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 309 5 4 5 0.6 CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2 10.1038/s41467-023-40064-9
DB01203 192614 None 37 Human Functional pAC50 = 7.0 7.0 -5 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 309 5 4 5 0.6 CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2 10.1038/s41467-023-40064-9
72093 35059 None 9 Human Functional pAC50 = 5.0 5.0 -10 28
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL1433361 35059 None 9 Human Functional pAC50 = 5.0 5.0 -10 28
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL2103773 35059 None 9 Human Functional pAC50 = 5.0 5.0 -10 28
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
4418 34220 None 85 Human Functional pAC50 = 6.0 6.0 -19 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1038/s41467-023-40064-9
CHEMBL142635 34220 None 85 Human Functional pAC50 = 6.0 6.0 -19 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1038/s41467-023-40064-9
DB12092 34220 None 85 Human Functional pAC50 = 6.0 6.0 -19 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1038/s41467-023-40064-9
12582 949 None 45 Human Functional pAC50 = 7.0 7.0 -1 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 276 3 3 3 3.0 CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O 10.1038/s41467-023-40064-9
2783 949 None 45 Human Functional pAC50 = 7.0 7.0 -1 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 276 3 3 3 3.0 CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O 10.1038/s41467-023-40064-9
CHEMBL49080 949 None 45 Human Functional pAC50 = 7.0 7.0 -1 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 276 3 3 3 3.0 CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O 10.1038/s41467-023-40064-9
DB01407 949 None 45 Human Functional pAC50 = 7.0 7.0 -1 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 276 3 3 3 3.0 CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O 10.1038/s41467-023-40064-9
3083544 26807 None 51 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
CHEMBL1200811 26807 None 51 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
CHEMBL1363 26807 None 51 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
CHEMBL1951071 26807 None 51 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
CHEMBL605993 26807 None 51 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
DB00983 26807 None 51 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
DB01274 26807 None 51 Human Functional pAC50 = 6.0 6.0 -199 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 344 9 4 5 2.2 COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1 10.1038/s41467-023-40064-9
100 3803 None 58 Human Functional pAC50 = 4.9 4.9 -2754 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
2637 3803 None 58 Human Functional pAC50 = 4.9 4.9 -2754 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
5452 3803 None 58 Human Functional pAC50 = 4.9 4.9 -2754 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
CHEMBL479 3803 None 58 Human Functional pAC50 = 4.9 4.9 -2754 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
DB00679 3803 None 58 Human Functional pAC50 = 4.9 4.9 -2754 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
11980903 14490 None 19 Human Functional pAC50 = 4.9 4.9 -354 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
22526 14490 None 19 Human Functional pAC50 = 4.9 4.9 -354 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
5281035 14490 None 19 Human Functional pAC50 = 4.9 4.9 -354 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1201303 14490 None 19 Human Functional pAC50 = 4.9 4.9 -354 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
2713 205269 None 82 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5353524 205269 None 82 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5360566 205269 None 82 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
88536661 205269 None 82 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
9552079 205269 None 82 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1330113 205269 None 82 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL790 205269 None 82 Human Functional pAC50 = 5.9 5.9 -2 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
6436135 99570 None 43 Human Functional pAC50 = 4.9 4.9 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 412 9 2 4 5.8 CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL283754 99570 None 43 Human Functional pAC50 = 4.9 4.9 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 412 9 2 4 5.8 CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O 10.1038/s41467-023-40064-9
5906 14493 None 23 Human Functional pAC50 = 4.8 4.8 -1 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 167 2 3 3 0.8 C[C@H](N)[C@H](O)c1cccc(O)c1 10.1038/s41467-023-40064-9
CHEMBL1201319 14493 None 23 Human Functional pAC50 = 4.8 4.8 -1 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 167 2 3 3 0.8 C[C@H](N)[C@H](O)c1cccc(O)c1 10.1038/s41467-023-40064-9
DB00610 14493 None 23 Human Functional pAC50 = 4.8 4.8 -1 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 167 2 3 3 0.8 C[C@H](N)[C@H](O)c1cccc(O)c1 10.1038/s41467-023-40064-9
202 1507 None 77 Human Functional pAC50 = 4.8 4.8 -10 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
60835 1507 None 77 Human Functional pAC50 = 4.8 4.8 -10 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
972 1507 None 77 Human Functional pAC50 = 4.8 4.8 -10 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1175 1507 None 77 Human Functional pAC50 = 4.8 4.8 -10 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
DB00476 1507 None 77 Human Functional pAC50 = 4.8 4.8 -10 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
3191 102856 None 97 Human Functional pAC50 = 4.8 4.8 -831 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 10.1038/s41467-023-40064-9
CHEMBL305660 102856 None 97 Human Functional pAC50 = 4.8 4.8 -831 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 10.1038/s41467-023-40064-9
DB11742 102856 None 97 Human Functional pAC50 = 4.8 4.8 -831 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 10.1038/s41467-023-40064-9
1786 2518 None 85 Human Functional pAC50 = 5.8 5.8 -10 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
4171 2518 None 85 Human Functional pAC50 = 5.8 5.8 -10 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
553 2518 None 85 Human Functional pAC50 = 5.8 5.8 -10 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
CHEMBL13 2518 None 85 Human Functional pAC50 = 5.8 5.8 -10 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
DB00264 2518 None 85 Human Functional pAC50 = 5.8 5.8 -10 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
6436173 55114 None 45 Human Functional pAC50 = 4.8 4.8 -4 22
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1617 55114 None 45 Human Functional pAC50 = 4.8 4.8 -4 22
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
2274 3171 None 58 Human Functional pAC50 = 4.8 4.8 -1047 37
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
4917 3171 None 58 Human Functional pAC50 = 4.8 4.8 -1047 37
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
7279 3171 None 58 Human Functional pAC50 = 4.8 4.8 -1047 37
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
CHEMBL728 3171 None 58 Human Functional pAC50 = 4.8 4.8 -1047 37
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
DB00433 3171 None 58 Human Functional pAC50 = 4.8 4.8 -1047 37
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
3464 3170 None 28 Human Functional pAC50 = 4.8 4.8 -616 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 290 5 4 4 2.0 CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C 10.1038/s41467-023-40064-9
4916 3170 None 28 Human Functional pAC50 = 4.8 4.8 -616 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 290 5 4 4 2.0 CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C 10.1038/s41467-023-40064-9
CHEMBL160519 3170 None 28 Human Functional pAC50 = 4.8 4.8 -616 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 290 5 4 4 2.0 CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C 10.1038/s41467-023-40064-9
DB01366 3170 None 28 Human Functional pAC50 = 4.8 4.8 -616 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 290 5 4 4 2.0 CCC(C(c1ccc(c2c1ccc(=O)[nH]2)O)O)NC(C)C 10.1038/s41467-023-40064-9
31729 205782 None 10 Human Functional pAC50 = 4.8 4.8 -707 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 287 6 4 4 2.4 CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1 10.1038/s41467-023-40064-9
CHEMBL83063 205782 None 10 Human Functional pAC50 = 4.8 4.8 -707 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 287 6 4 4 2.4 CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1 10.1038/s41467-023-40064-9
3926 207239 None 40 Human Functional pAC50 = 4.8 4.8 -27 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
CHEMBL92870 207239 None 40 Human Functional pAC50 = 4.8 4.8 -27 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
1016 3745 None 78 Human Functional pAC50 = 4.8 4.8 -2344 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2561 3745 None 78 Human Functional pAC50 = 4.8 4.8 -2344 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2733526 3745 None 78 Human Functional pAC50 = 4.8 4.8 -2344 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
5384 3745 None 78 Human Functional pAC50 = 4.8 4.8 -2344 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL83 3745 None 78 Human Functional pAC50 = 4.8 4.8 -2344 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
DB00675 3745 None 78 Human Functional pAC50 = 4.8 4.8 -2344 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2267 559 None 71 Human Functional pAC50 = 4.8 4.8 -741 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
271 559 None 71 Human Functional pAC50 = 4.8 4.8 -741 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
7121 559 None 71 Human Functional pAC50 = 4.8 4.8 -741 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
CHEMBL639 559 None 71 Human Functional pAC50 = 4.8 4.8 -741 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
DB00972 559 None 71 Human Functional pAC50 = 4.8 4.8 -741 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
2435 3588 None 83 Human Functional pAC50 = 4.8 4.8 -4365 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
60149 3588 None 83 Human Functional pAC50 = 4.8 4.8 -4365 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
98 3588 None 83 Human Functional pAC50 = 4.8 4.8 -4365 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
CHEMBL12713 3588 None 83 Human Functional pAC50 = 4.8 4.8 -4365 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
DB06144 3588 None 83 Human Functional pAC50 = 4.8 4.8 -4365 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
2540 4399 None 111 Human Functional pAC50 = 4.8 4.8 -2570 28
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 4399 None 111 Human Functional pAC50 = 4.8 4.8 -2570 28
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
64139 84783 None 96 Human Functional pAC50 = 4.7 4.7 -3 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
CHEMBL223228 84783 None 96 Human Functional pAC50 = 4.7 4.7 -3 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
451668 14455 None 110 Human Functional pAC50 = 4.7 4.7 - 1
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 228 2 3 8 -2.1 Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1 10.1038/s41467-023-40064-9
CHEMBL1201129 14455 None 110 Human Functional pAC50 = 4.7 4.7 - 1
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 228 2 3 8 -2.1 Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1 10.1038/s41467-023-40064-9
33624 3819 None 34 Human Functional pAC50 = 8.6 8.6 -3 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1038/s41467-023-40064-9
4061 3819 None 34 Human Functional pAC50 = 8.6 8.6 -3 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1038/s41467-023-40064-9
565 3819 None 34 Human Functional pAC50 = 8.6 8.6 -3 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1038/s41467-023-40064-9
CHEMBL499 3819 None 34 Human Functional pAC50 = 8.6 8.6 -3 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1038/s41467-023-40064-9
DB00373 3819 None 34 Human Functional pAC50 = 8.6 8.6 -3 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 316 6 2 8 0.5 O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C 10.1038/s41467-023-40064-9
1222 1662 None 49 Human Functional pAC50 = 4.7 4.7 -467 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3396 1662 None 49 Human Functional pAC50 = 4.7 4.7 -467 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
85 1662 None 49 Human Functional pAC50 = 4.7 4.7 -467 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL46516 1662 None 49 Human Functional pAC50 = 4.7 4.7 -467 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
DB04842 1662 None 49 Human Functional pAC50 = 4.7 4.7 -467 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
1836 2590 None 59 Human Functional pAC50 = 4.7 4.7 -39810 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
3340 2590 None 59 Human Functional pAC50 = 4.7 4.7 -39810 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
5281040 2590 None 59 Human Functional pAC50 = 4.7 4.7 -39810 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
CHEMBL787 2590 None 59 Human Functional pAC50 = 4.7 4.7 -39810 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
DB00471 2590 None 59 Human Functional pAC50 = 4.7 4.7 -39810 18
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 10.1038/s41467-023-40064-9
5591 157529 None 90 Human Functional pAC50 = 4.7 4.7 -12 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
CHEMBL408 157529 None 90 Human Functional pAC50 = 4.7 4.7 -12 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
3151 1461 None 97 Human Functional pAC50 = 4.7 4.7 -7585 24
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
945 1461 None 97 Human Functional pAC50 = 4.7 4.7 -7585 24
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
965 1461 None 97 Human Functional pAC50 = 4.7 4.7 -7585 24
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL219916 1461 None 97 Human Functional pAC50 = 4.7 4.7 -7585 24
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB01184 1461 None 97 Human Functional pAC50 = 4.7 4.7 -7585 24
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2303 3185 None 68 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
4946 3185 None 68 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
564 3185 None 68 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
63 3185 None 68 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
91536 3185 None 68 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL27 3185 None 68 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL452861 3185 None 68 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
DB00571 3185 None 68 Human Functional pAC50 = 7.7 7.7 -6 20
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
5282219 35867 None 63 Human Functional pAC50 = 4.7 4.7 -3 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 450 12 1 5 5.7 CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 10.1038/s41467-023-40064-9
CHEMBL1441961 35867 None 63 Human Functional pAC50 = 4.7 4.7 -3 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 450 12 1 5 5.7 CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 10.1038/s41467-023-40064-9
105 3459 None 91 Human Functional pAC50 = 4.7 4.7 -28 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1038/s41467-023-40064-9
2083 3459 None 91 Human Functional pAC50 = 4.7 4.7 -28 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1038/s41467-023-40064-9
558 3459 None 91 Human Functional pAC50 = 4.7 4.7 -28 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1038/s41467-023-40064-9
CHEMBL714 3459 None 91 Human Functional pAC50 = 4.7 4.7 -28 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1038/s41467-023-40064-9
DB01001 3459 None 91 Human Functional pAC50 = 4.7 4.7 -28 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1038/s41467-023-40064-9
11976 919 None 59 Human Functional pAC50 = 4.7 4.7 -7244 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
667467 919 None 59 Human Functional pAC50 = 4.7 4.7 -7244 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
CHEMBL908 919 None 59 Human Functional pAC50 = 4.7 4.7 -7244 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
DB01239 919 None 59 Human Functional pAC50 = 4.7 4.7 -7244 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 315 3 0 2 5.2 CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl 10.1038/s41467-023-40064-9
155774 4094 None 40 Human Functional pAC50 = 6.7 6.7 42 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1038/s41467-023-40064-9
2848 4094 None 40 Human Functional pAC50 = 6.7 6.7 42 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1038/s41467-023-40064-9
538 4094 None 40 Human Functional pAC50 = 6.7 6.7 42 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1038/s41467-023-40064-9
CHEMBL75753 4094 None 40 Human Functional pAC50 = 6.7 6.7 42 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1038/s41467-023-40064-9
DB13781 4094 None 40 Human Functional pAC50 = 6.7 6.7 42 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1038/s41467-023-40064-9
180 401 None 56 Human Functional pAC50 = 4.6 4.6 -48977 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
200 401 None 56 Human Functional pAC50 = 4.6 4.6 -48977 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
2160 401 None 56 Human Functional pAC50 = 4.6 4.6 -48977 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL629 401 None 56 Human Functional pAC50 = 4.6 4.6 -48977 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00321 401 None 56 Human Functional pAC50 = 4.6 4.6 -48977 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
3689 102769 None 55 Human Functional pAC50 = 4.6 4.6 -3311 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 5 2 3 3.8 CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL1372983 102769 None 55 Human Functional pAC50 = 4.6 4.6 -3311 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 5 2 3 3.8 CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL305187 102769 None 55 Human Functional pAC50 = 4.6 4.6 -3311 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 5 2 3 3.8 CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 10.1038/s41467-023-40064-9
1971 2864 None 38 Human Functional pAC50 = 4.6 4.6 -33113 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
2404 2864 None 38 Human Functional pAC50 = 4.6 4.6 -33113 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
4543 2864 None 38 Human Functional pAC50 = 4.6 4.6 -33113 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL445 2864 None 38 Human Functional pAC50 = 4.6 4.6 -33113 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
DB00540 2864 None 38 Human Functional pAC50 = 4.6 4.6 -33113 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 10.1038/s41467-023-40064-9
5482 14418 None 80 Human Functional pAC50 = 4.6 4.6 -13 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 6 0 4 5.9 Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1200438 14418 None 80 Human Functional pAC50 = 4.6 4.6 -13 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 6 0 4 5.9 Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
2419 3461 None 84 Human Functional pAC50 = 5.6 5.6 -1174 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
5152 3461 None 84 Human Functional pAC50 = 5.6 5.6 -1174 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
559 3461 None 84 Human Functional pAC50 = 5.6 5.6 -1174 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
CHEMBL1263 3461 None 84 Human Functional pAC50 = 5.6 5.6 -1174 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
DB00938 3461 None 84 Human Functional pAC50 = 5.6 5.6 -1174 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1038/s41467-023-40064-9
129211 3747 None 78 Human Functional pAC50 = 5.6 5.6 -5495 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
2562 3747 None 78 Human Functional pAC50 = 5.6 5.6 -5495 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
488 3747 None 78 Human Functional pAC50 = 5.6 5.6 -5495 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
CHEMBL836 3747 None 78 Human Functional pAC50 = 5.6 5.6 -5495 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
DB00706 3747 None 78 Human Functional pAC50 = 5.6 5.6 -5495 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1038/s41467-023-40064-9
26987 948 None 33 Human Functional pAC50 = 4.6 4.6 -21877 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
6063 948 None 33 Human Functional pAC50 = 4.6 4.6 -21877 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
671 948 None 33 Human Functional pAC50 = 4.6 4.6 -21877 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
CHEMBL1626 948 None 33 Human Functional pAC50 = 4.6 4.6 -21877 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
DB00283 948 None 33 Human Functional pAC50 = 4.6 4.6 -21877 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
4640 78264 None 30 Human Functional pAC50 = 4.6 4.6 -218 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 379 6 1 4 3.9 COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC 10.1038/s41467-023-40064-9
CHEMBL2107011 78264 None 30 Human Functional pAC50 = 4.6 4.6 -218 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 379 6 1 4 3.9 COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC 10.1038/s41467-023-40064-9
4486 122981 None 25 Human Functional pAC50 = 4.6 4.6 - 1
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 11 2 9 0.3 Cn1c(NCCN(CCO)CCCc2ccc([N+](=O)[O-])cc2)cc(=O)n(C)c1=O 10.1038/s41467-023-40064-9
CHEMBL360861 122981 None 25 Human Functional pAC50 = 4.6 4.6 - 1
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 11 2 9 0.3 Cn1c(NCCN(CCO)CCCc2ccc([N+](=O)[O-])cc2)cc(=O)n(C)c1=O 10.1038/s41467-023-40064-9
1549120 196484 None 85 Human Functional pAC50 = 4.6 4.6 -17 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL56337 196484 None 85 Human Functional pAC50 = 4.6 4.6 -17 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
2372 106466 None 40 Human Functional pAC50 = 7.6 7.6 12 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 345 10 2 5 2.6 COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC 10.1038/s41467-023-40064-9
CHEMBL314010 106466 None 40 Human Functional pAC50 = 7.6 7.6 12 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 345 10 2 5 2.6 COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC 10.1038/s41467-023-40064-9
5606 10191 None 67 Human Functional pAC50 = 5.6 5.6 -3 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 227 3 2 2 2.8 CC(C)(C)NCC(O)c1ccccc1Cl 10.1038/s41467-023-40064-9
CHEMBL1159717 10191 None 67 Human Functional pAC50 = 5.6 5.6 -3 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 227 3 2 2 2.8 CC(C)(C)NCC(O)c1ccccc1Cl 10.1038/s41467-023-40064-9
DB12248 10191 None 67 Human Functional pAC50 = 5.6 5.6 -3 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 227 3 2 2 2.8 CC(C)(C)NCC(O)c1ccccc1Cl 10.1038/s41467-023-40064-9
65948 18554 None 109 Human Functional pAC50 = 4.6 4.6 -12 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 582 9 2 9 4.7 CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 10.1038/s41467-023-40064-9
CHEMBL1275868 18554 None 109 Human Functional pAC50 = 4.6 4.6 -12 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 582 9 2 9 4.7 CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 10.1038/s41467-023-40064-9
4908 188804 None 78 Human Functional pAC50 = 4.6 4.6 -5 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 4 2.8 COc1cc(NC(C)CCCN)c2ncccc2c1 10.1038/s41467-023-40064-9
CHEMBL506 188804 None 78 Human Functional pAC50 = 4.6 4.6 -5 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 259 6 2 4 2.8 COc1cc(NC(C)CCCN)c2ncccc2c1 10.1038/s41467-023-40064-9
4452 2760 None 19 Human Functional pAC50 = 5.6 5.6 -8912 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
983 2760 None 19 Human Functional pAC50 = 5.6 5.6 -8912 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
CHEMBL20734 2760 None 19 Human Functional pAC50 = 5.6 5.6 -8912 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
2470 3651 None 50 Human Functional pAC50 = 5.6 5.6 -46773 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3300 3651 None 50 Human Functional pAC50 = 5.6 5.6 -46773 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
5265 3651 None 50 Human Functional pAC50 = 5.6 5.6 -46773 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
99 3651 None 50 Human Functional pAC50 = 5.6 5.6 -46773 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL267930 3651 None 50 Human Functional pAC50 = 5.6 5.6 -46773 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
216239 23793 None 118 Human Functional pAC50 = 4.6 4.6 -15 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
CHEMBL1200485 23793 None 118 Human Functional pAC50 = 4.6 4.6 -15 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
CHEMBL1336 23793 None 118 Human Functional pAC50 = 4.6 4.6 -15 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
3760 50298 None 37 Human Functional pAC50 = 4.6 4.6 -3 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 414 6 0 3 6.5 Clc1ccc(C(Cn2ccnc2)OCc2c(Cl)cccc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1571863 50298 None 37 Human Functional pAC50 = 4.6 4.6 -3 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 414 6 0 3 6.5 Clc1ccc(C(Cn2ccnc2)OCc2c(Cl)cccc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
30323 62483 None 57 Human Functional pAC50 = 4.6 4.6 -14 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL1563 62483 None 57 Human Functional pAC50 = 4.6 4.6 -14 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL178 62483 None 57 Human Functional pAC50 = 4.6 4.6 -14 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 527 4 5 11 1.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
135398735 136966 None 32 Human Functional pAC50 = 4.6 4.6 -12 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
136262914 136966 None 32 Human Functional pAC50 = 4.6 4.6 -12 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL374478 136966 None 32 Human Functional pAC50 = 4.6 4.6 -12 27
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
176 398 None 66 Human Functional pAC50 = 5.5 5.5 -4 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2157 398 None 66 Human Functional pAC50 = 5.5 5.5 -4 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2566 398 None 66 Human Functional pAC50 = 5.5 5.5 -4 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
CHEMBL633 398 None 66 Human Functional pAC50 = 5.5 5.5 -4 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
DB01118 398 None 66 Human Functional pAC50 = 5.5 5.5 -4 40
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 10.1038/s41467-023-40064-9
2333 142333 None 97 Human Functional pAC50 = 4.5 4.5 -25 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
CHEMBL388590 142333 None 97 Human Functional pAC50 = 4.5 4.5 -25 14
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
118422671 2755 None 65 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
1887 2755 None 65 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
189562 2755 None 65 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
71301 2755 None 65 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
7246 2755 None 65 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
9844194 2755 None 65 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
CHEMBL2365658 2755 None 65 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
CHEMBL3526436 2755 None 65 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
CHEMBL434394 2755 None 65 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
DB04861 2755 None 65 Human Functional pAC50 = 8.5 8.5 22 23
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
2585 802 None 103 Human Functional pAC50 = 8.5 8.5 1 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
522 802 None 103 Human Functional pAC50 = 8.5 8.5 1 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
551 802 None 103 Human Functional pAC50 = 8.5 8.5 1 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
CHEMBL723 802 None 103 Human Functional pAC50 = 8.5 8.5 1 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
DB01136 802 None 103 Human Functional pAC50 = 8.5 8.5 1 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
3149 12612 None 15 Human Functional pAC50 = 5.5 5.5 -8 26
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1187011 12612 None 15 Human Functional pAC50 = 5.5 5.5 -8 26
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
2601 3778 None 33 Human Functional pAC50 = 5.5 5.5 -1023 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
443951 3778 None 33 Human Functional pAC50 = 5.5 5.5 -1023 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
56 3778 None 33 Human Functional pAC50 = 5.5 5.5 -1023 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
CHEMBL73151 3778 None 33 Human Functional pAC50 = 5.5 5.5 -1023 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
DB13399 3778 None 33 Human Functional pAC50 = 5.5 5.5 -1023 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
5311064 1365 None 46 Human Functional pAC50 = 5.5 5.5 3 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 317 8 3 5 2.3 COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC 10.1038/s41467-023-40064-9
534 1365 None 46 Human Functional pAC50 = 5.5 5.5 3 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 317 8 3 5 2.3 COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC 10.1038/s41467-023-40064-9
806 1365 None 46 Human Functional pAC50 = 5.5 5.5 3 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 317 8 3 5 2.3 COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC 10.1038/s41467-023-40064-9
CHEMBL493682 1365 None 46 Human Functional pAC50 = 5.5 5.5 3 7
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 317 8 3 5 2.3 COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC 10.1038/s41467-023-40064-9
150 2507 None 21 Human Functional pAC50 = 5.4 5.4 -1445 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
1764 2507 None 21 Human Functional pAC50 = 5.4 5.4 -1445 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
8226 2507 None 21 Human Functional pAC50 = 5.4 5.4 -1445 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
CHEMBL1201356 2507 None 21 Human Functional pAC50 = 5.4 5.4 -1445 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
DB00353 2507 None 21 Human Functional pAC50 = 5.4 5.4 -1445 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO 10.1038/s41467-023-40064-9
2291 3182 None 58 Human Functional pAC50 = 6.4 6.4 -6 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O 10.1038/s41467-023-40064-9
2561 3182 None 58 Human Functional pAC50 = 6.4 6.4 -6 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O 10.1038/s41467-023-40064-9
4932 3182 None 58 Human Functional pAC50 = 6.4 6.4 -6 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O 10.1038/s41467-023-40064-9
CHEMBL631 3182 None 58 Human Functional pAC50 = 6.4 6.4 -6 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O 10.1038/s41467-023-40064-9
DB01182 3182 None 58 Human Functional pAC50 = 6.4 6.4 -6 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O 10.1038/s41467-023-40064-9
2464 3638 None 58 Human Functional pAC50 = 5.4 5.4 -7 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 272 6 3 4 1.1 CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C 10.1038/s41467-023-40064-9
5253 3638 None 58 Human Functional pAC50 = 5.4 5.4 -7 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 272 6 3 4 1.1 CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C 10.1038/s41467-023-40064-9
7297 3638 None 58 Human Functional pAC50 = 5.4 5.4 -7 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 272 6 3 4 1.1 CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C 10.1038/s41467-023-40064-9
CHEMBL471 3638 None 58 Human Functional pAC50 = 5.4 5.4 -7 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 272 6 3 4 1.1 CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C 10.1038/s41467-023-40064-9
DB00489 3638 None 58 Human Functional pAC50 = 5.4 5.4 -7 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 272 6 3 4 1.1 CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C 10.1038/s41467-023-40064-9
4567 9946 None 34 Human Functional pAC50 = 5.4 5.4 -72 12
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 7 3 3 3.4 CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1 10.1038/s41467-023-40064-9
CHEMBL114655 9946 None 34 Human Functional pAC50 = 5.4 5.4 -72 12
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 7 3 3 3.4 CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1 10.1038/s41467-023-40064-9
2176 3125 None 68 Human Functional pAC50 = 8.4 8.4 -1 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1038/s41467-023-40064-9
4828 3125 None 68 Human Functional pAC50 = 8.4 8.4 -1 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1038/s41467-023-40064-9
91 3125 None 68 Human Functional pAC50 = 8.4 8.4 -1 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL500 3125 None 68 Human Functional pAC50 = 8.4 8.4 -1 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1038/s41467-023-40064-9
DB00960 3125 None 68 Human Functional pAC50 = 8.4 8.4 -1 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 248 6 3 3 1.9 OC(COc1cccc2c1cc[nH]2)CNC(C)C 10.1038/s41467-023-40064-9
44112 121288 None 48 Human Functional pAC50 = 8.3 8.3 -1 12
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 380 7 2 4 4.5 Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1 10.1038/s41467-023-40064-9
CHEMBL357995 121288 None 48 Human Functional pAC50 = 8.3 8.3 -1 12
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 380 7 2 4 4.5 Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1 10.1038/s41467-023-40064-9
9931954 10932 None 76 Human Functional pAC50 = 4.4 4.4 -3 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 323 3 3 2 3.0 CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 10.1038/s41467-023-40064-9
CHEMBL1173055 10932 None 76 Human Functional pAC50 = 4.4 4.4 -3 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 323 3 3 2 3.0 CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 10.1038/s41467-023-40064-9
3486 3155 None 56 Human Functional pAC50 = 5.3 5.3 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1038/s41467-023-40064-9
4883 3155 None 56 Human Functional pAC50 = 5.3 5.3 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1038/s41467-023-40064-9
555 3155 None 56 Human Functional pAC50 = 5.3 5.3 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL6995 3155 None 56 Human Functional pAC50 = 5.3 5.3 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1038/s41467-023-40064-9
DB01297 3155 None 56 Human Functional pAC50 = 5.3 5.3 -1 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 7 3 4 1.4 OC(COc1ccc(cc1)NC(=O)C)CNC(C)C 10.1038/s41467-023-40064-9
25382 9155 None 37 Human Functional pAC50 = 5.3 5.3 -141 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 291 3 0 1 4.7 CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL110094 9155 None 37 Human Functional pAC50 = 5.3 5.3 -141 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 291 3 0 1 4.7 CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21 10.1038/s41467-023-40064-9
36811 1453 None 37 Human Functional pAC50 = 5.3 5.3 -11 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
535 1453 None 37 Human Functional pAC50 = 5.3 5.3 -11 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
937 1453 None 37 Human Functional pAC50 = 5.3 5.3 -11 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
CHEMBL926 1453 None 37 Human Functional pAC50 = 5.3 5.3 -11 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
DB00841 1453 None 37 Human Functional pAC50 = 5.3 5.3 -11 17
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O 10.1038/s41467-023-40064-9
16362 3123 None 71 Human Functional pAC50 = 5.3 5.3 -616 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2172 3123 None 71 Human Functional pAC50 = 5.3 5.3 -616 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
90 3123 None 71 Human Functional pAC50 = 5.3 5.3 -616 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1423 3123 None 71 Human Functional pAC50 = 5.3 5.3 -616 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB01100 3123 None 71 Human Functional pAC50 = 5.3 5.3 -616 35
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2318 154854 None 29 Human Functional pAC50 = 5.2 5.2 -8 15
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 351 7 1 3 4.1 CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL400599 154854 None 29 Human Functional pAC50 = 5.2 5.2 -8 15
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 351 7 1 3 4.1 CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1 10.1038/s41467-023-40064-9
11504295 2921 None 47 Human Functional pAC50 = 6.2 6.2 -954 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
4814 2921 None 47 Human Functional pAC50 = 6.2 6.2 -954 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
7543 2921 None 47 Human Functional pAC50 = 6.2 6.2 -954 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
CHEMBL605846 2921 None 47 Human Functional pAC50 = 6.2 6.2 -954 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
DB09080 2921 None 47 Human Functional pAC50 = 6.2 6.2 -954 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
2398 953 None 62 Human Functional pAC50 = 5.2 5.2 -4265 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
2801 953 None 62 Human Functional pAC50 = 5.2 5.2 -4265 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
701 953 None 62 Human Functional pAC50 = 5.2 5.2 -4265 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
CHEMBL415 953 None 62 Human Functional pAC50 = 5.2 5.2 -4265 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
DB01242 953 None 62 Human Functional pAC50 = 5.2 5.2 -4265 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C 10.1038/s41467-023-40064-9
1499 2089 None 47 Human Functional pAC50 = 6.2 6.2 -58 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
3779 2089 None 47 Human Functional pAC50 = 6.2 6.2 -58 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
536 2089 None 47 Human Functional pAC50 = 6.2 6.2 -58 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
CHEMBL434 2089 None 47 Human Functional pAC50 = 6.2 6.2 -58 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
DB01064 2089 None 47 Human Functional pAC50 = 6.2 6.2 -58 38
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1038/s41467-023-40064-9
137 370 None 52 Human Functional pAC50 = 8.2 8.2 -3 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
2119 370 None 52 Human Functional pAC50 = 8.2 8.2 -3 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
563 370 None 52 Human Functional pAC50 = 8.2 8.2 -3 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
66368 370 None 52 Human Functional pAC50 = 8.2 8.2 -3 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
CHEMBL266195 370 None 52 Human Functional pAC50 = 8.2 8.2 -3 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
DB00866 370 None 52 Human Functional pAC50 = 8.2 8.2 -3 8
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 249 8 2 3 2.2 C=CCc1ccccc1OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
4631 194970 None 29 Human Functional pAC50 = 8.2 8.2 -1 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 265 9 2 4 2.0 C=CCOc1ccccc1OCC(O)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL546 194970 None 29 Human Functional pAC50 = 8.2 8.2 -1 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 265 9 2 4 2.0 C=CCOc1ccccc1OCC(O)CNC(C)C 10.1038/s41467-023-40064-9
DB01580 194970 None 29 Human Functional pAC50 = 8.2 8.2 -1 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 265 9 2 4 2.0 C=CCOc1ccccc1OCC(O)CNC(C)C 10.1038/s41467-023-40064-9
2169 44845 None 35 Human Functional pAC50 = 7.2 7.2 1 12
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 380 9 3 6 1.4 COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1 10.1038/s41467-023-40064-9
CHEMBL152231 44845 None 35 Human Functional pAC50 = 7.2 7.2 1 12
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 380 9 3 6 1.4 COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1 10.1038/s41467-023-40064-9
1155 1627 None 53 Human Functional pAC50 = 5.2 5.2 -17 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
3343 1627 None 53 Human Functional pAC50 = 5.2 5.2 -17 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
557 1627 None 53 Human Functional pAC50 = 5.2 5.2 -17 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
CHEMBL32800 1627 None 53 Human Functional pAC50 = 5.2 5.2 -17 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
DB01288 1627 None 53 Human Functional pAC50 = 5.2 5.2 -17 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 303 6 5 5 2.1 CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O 10.1038/s41467-023-40064-9
5329102 194724 None 86 Human Functional pAC50 = 5.2 5.2 -54 37
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
CHEMBL535 194724 None 86 Human Functional pAC50 = 5.2 5.2 -54 37
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
2249 512 None 111 Human Functional pAC50 = 6.2 6.2 -38 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C 10.1038/s41467-023-40064-9
255 512 None 111 Human Functional pAC50 = 6.2 6.2 -38 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C 10.1038/s41467-023-40064-9
548 512 None 111 Human Functional pAC50 = 6.2 6.2 -38 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL24 512 None 111 Human Functional pAC50 = 6.2 6.2 -38 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C 10.1038/s41467-023-40064-9
DB00335 512 None 111 Human Functional pAC50 = 6.2 6.2 -38 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 266 8 3 4 0.5 OC(COc1ccc(cc1)CC(=O)N)CNC(C)C 10.1038/s41467-023-40064-9
9801 91583 None 35 Human Functional pAC50 = 5.2 5.2 -17 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 329 8 1 1 5.4 CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL24072 91583 None 35 Human Functional pAC50 = 5.2 5.2 -17 16
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 329 8 1 1 5.4 CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
135409453 3771 None 41 Human Functional pAC50 = 5.2 5.2 -2398 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
226 3771 None 41 Human Functional pAC50 = 5.2 5.2 -2398 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
CHEMBL76370 3771 None 41 Human Functional pAC50 = 5.2 5.2 -2398 36
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
242 470 None 124 Human Functional pAC50 = 6.1 6.1 -213 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
34 470 None 124 Human Functional pAC50 = 6.1 6.1 -213 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795 470 None 124 Human Functional pAC50 = 6.1 6.1 -213 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
CHEMBL1112 470 None 124 Human Functional pAC50 = 6.1 6.1 -213 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
DB01238 470 None 124 Human Functional pAC50 = 6.1 6.1 -213 33
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
2663 98760 None 34 Human Functional pAC50 = 7.1 7.1 60 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 379 9 3 5 2.9 CCN(CC)C(=O)Nc1ccc(OCC(O)CNC(C)(C)C)c(C(C)=O)c1 10.1038/s41467-023-40064-9
CHEMBL27810 98760 None 34 Human Functional pAC50 = 7.1 7.1 60 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 379 9 3 5 2.9 CCN(CC)C(=O)Nc1ccc(OCC(O)CNC(C)(C)C)c(C(C)=O)c1 10.1038/s41467-023-40064-9
DB04846 98760 None 34 Human Functional pAC50 = 7.1 7.1 60 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 379 9 3 5 2.9 CCN(CC)C(=O)Nc1ccc(OCC(O)CNC(C)(C)C)c(C(C)=O)c1 10.1038/s41467-023-40064-9
2335 11846 None 22 Human Functional pAC50 = 5.1 5.1 -57 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
8478 11846 None 22 Human Functional pAC50 = 5.1 5.1 -57 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1182210 11846 None 22 Human Functional pAC50 = 5.1 5.1 -57 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL221753 11846 None 22 Human Functional pAC50 = 5.1 5.1 -57 34
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
56959 31554 None 103 Human Functional pAC50 = 5.1 5.1 -5 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 427 9 2 6 2.3 COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1 10.1038/s41467-023-40064-9
CHEMBL1404 31554 None 103 Human Functional pAC50 = 5.1 5.1 -5 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 427 9 2 6 2.3 COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1 10.1038/s41467-023-40064-9
CHEMBL1526084 31554 None 103 Human Functional pAC50 = 5.1 5.1 -5 9
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 427 9 2 6 2.3 COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1 10.1038/s41467-023-40064-9
5639 98893 None 75 Human Functional pAC50 = 6.1 6.1 -15 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 387 7 1 8 0.7 COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1 10.1038/s41467-023-40064-9
CHEMBL279229 98893 None 75 Human Functional pAC50 = 6.1 6.1 -15 13
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 387 7 1 8 0.7 COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1 10.1038/s41467-023-40064-9
2351 4298 None 49 Human Functional pAC50 = 5.1 5.1 -3 22
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
CHEMBL1008 4298 None 49 Human Functional pAC50 = 5.1 5.1 -3 22
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
CHEMBL1257078 4298 None 49 Human Functional pAC50 = 5.1 5.1 -3 22
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
11658860 2342 None 51 Human Functional pAC50 = 5.1 5.1 -724 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
2941 2342 None 51 Human Functional pAC50 = 5.1 5.1 -724 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
4374 2342 None 51 Human Functional pAC50 = 5.1 5.1 -724 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
CHEMBL360328 2342 None 51 Human Functional pAC50 = 5.1 5.1 -724 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
DB04871 2342 None 51 Human Functional pAC50 = 5.1 5.1 -724 11
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
119607 206201 None 113 Human Functional pAC50 = 5.1 5.1 1 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 10.1038/s41467-023-40064-9
CHEMBL865 206201 None 113 Human Functional pAC50 = 5.1 5.1 1 6
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 10.1038/s41467-023-40064-9
68617 205525 None 62 Human Functional pAC50 = 5.1 5.1 -23 30
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1709 205525 None 62 Human Functional pAC50 = 5.1 5.1 -23 30
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL809 205525 None 62 Human Functional pAC50 = 5.1 5.1 -23 30
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 10.1038/s41467-023-40064-9
16363 595 None 53 Human Functional pAC50 = 5.1 5.1 -1621 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
312 595 None 53 Human Functional pAC50 = 5.1 5.1 -1621 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
9215 595 None 53 Human Functional pAC50 = 5.1 5.1 -1621 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL297302 595 None 53 Human Functional pAC50 = 5.1 5.1 -1621 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB12867 595 None 53 Human Functional pAC50 = 5.1 5.1 -1621 21
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
1054 1584 None 54 Human Functional pAC50 = 6.1 6.1 66 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 295 9 2 5 1.5 COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
59768 1584 None 54 Human Functional pAC50 = 6.1 6.1 66 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 295 9 2 5 1.5 COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
7178 1584 None 54 Human Functional pAC50 = 6.1 6.1 66 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 295 9 2 5 1.5 COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
CHEMBL768 1584 None 54 Human Functional pAC50 = 6.1 6.1 66 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 295 9 2 5 1.5 COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
DB00187 1584 None 54 Human Functional pAC50 = 6.1 6.1 66 2
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 295 9 2 5 1.5 COC(=O)CCc1ccc(cc1)OCC(CNC(C)C)O 10.1038/s41467-023-40064-9
275196 125671 None 52 Human Functional pAC50 = 5.1 5.1 -26 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 413 4 0 8 2.9 COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C 10.1038/s41467-023-40064-9
CHEMBL364713 125671 None 52 Human Functional pAC50 = 5.1 5.1 -26 5
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 413 4 0 8 2.9 COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C 10.1038/s41467-023-40064-9
156419 937 None 74 Human Functional pAC50 = 5.1 5.1 -138 15
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
3308 937 None 74 Human Functional pAC50 = 5.1 5.1 -138 15
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
647 937 None 74 Human Functional pAC50 = 5.1 5.1 -138 15
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL1201284 937 None 74 Human Functional pAC50 = 5.1 5.1 -138 15
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
DB01012 937 None 74 Human Functional pAC50 = 5.1 5.1 -138 15
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 357 6 1 1 6.1 C[C@H](c1cccc2c1cccc2)NCCCc1cccc(c1)C(F)(F)F 10.1038/s41467-023-40064-9
41684 31219 None 105 Human Functional pAC50 = 5.1 5.1 -19 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 31219 None 105 Human Functional pAC50 = 5.1 5.1 -19 32
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
1673 961 None 24 Human Functional pAC50 = 6.1 6.1 -1 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 1 1 4 1.5 COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C 10.1038/s41467-023-40064-9
5284371 961 None 24 Human Functional pAC50 = 6.1 6.1 -1 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 1 1 4 1.5 COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C 10.1038/s41467-023-40064-9
725 961 None 24 Human Functional pAC50 = 6.1 6.1 -1 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 1 1 4 1.5 COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C 10.1038/s41467-023-40064-9
CHEMBL485 961 None 24 Human Functional pAC50 = 6.1 6.1 -1 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 1 1 4 1.5 COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C 10.1038/s41467-023-40064-9
DB00318 961 None 24 Human Functional pAC50 = 6.1 6.1 -1 3
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 299 1 1 4 1.5 COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C 10.1038/s41467-023-40064-9
31101 728 None 40 Human Functional pAC50 = 5.0 5.0 -1659 29
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
35 728 None 40 Human Functional pAC50 = 5.0 5.0 -1659 29
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
403 728 None 40 Human Functional pAC50 = 5.0 5.0 -1659 29
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
CHEMBL493 728 None 40 Human Functional pAC50 = 5.0 5.0 -1659 29
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
DB01200 728 None 40 Human Functional pAC50 = 5.0 5.0 -1659 29
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
135564886 14491 None 5 Human Functional pAC50 = 5.0 5.0 -3 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
135673376 14491 None 5 Human Functional pAC50 = 5.0 5.0 -3 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
137157436 14491 None 5 Human Functional pAC50 = 5.0 5.0 -3 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
145948239 14491 None 5 Human Functional pAC50 = 5.0 5.0 -3 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
71587099 14491 None 5 Human Functional pAC50 = 5.0 5.0 -3 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
CHEMBL1201304 14491 None 5 Human Functional pAC50 = 5.0 5.0 -3 25
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
1028 291 None 71 Human Functional pAC50 = 6.0 6.0 -10 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
139148732 291 None 71 Human Functional pAC50 = 6.0 6.0 -10 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
479 291 None 71 Human Functional pAC50 = 6.0 6.0 -10 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
5816 291 None 71 Human Functional pAC50 = 6.0 6.0 -10 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
CHEMBL679 291 None 71 Human Functional pAC50 = 6.0 6.0 -10 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
DB00668 291 None 71 Human Functional pAC50 = 6.0 6.0 -10 19
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1038/s41467-023-40064-9
2405 664 None 76 Human Functional pAC50 = 7 7.0 -6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 12 2 5 2.4 OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C 10.1038/s41467-023-40064-9
380 664 None 76 Human Functional pAC50 = 7 7.0 -6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 12 2 5 2.4 OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C 10.1038/s41467-023-40064-9
7129 664 None 76 Human Functional pAC50 = 7 7.0 -6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 12 2 5 2.4 OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL645 664 None 76 Human Functional pAC50 = 7 7.0 -6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 12 2 5 2.4 OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C 10.1038/s41467-023-40064-9
DB00612 664 None 76 Human Functional pAC50 = 7 7.0 -6 4
Compound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity methodCompound was evaluated for inhibition of human ADRB1 in an in vitro assay measured by radioactivity method
ChEMBL 325 12 2 5 2.4 OC(COc1ccc(cc1)COCCOC(C)C)CNC(C)C 10.1038/s41467-023-40064-9
9849126 12437 None 0 Guinea pig Functional pEC50 = 10.4 10.4 3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 507 18 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1 10.1021/jm801016j
CHEMBL1185969 12437 None 0 Guinea pig Functional pEC50 = 10.4 10.4 3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 507 18 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1 10.1021/jm801016j
CHEMBL443435 12437 None 0 Guinea pig Functional pEC50 = 10.4 10.4 3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 507 18 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1 10.1021/jm801016j
1499 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm701324c
3779 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm701324c
536 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm701324c
CHEMBL434 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm701324c
DB01064 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm701324c
1499 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2008.08.009
3779 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2008.08.009
536 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2008.08.009
CHEMBL434 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2008.08.009
DB01064 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2008.08.009
1499 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm800222k
3779 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm800222k
536 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm800222k
CHEMBL434 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm800222k
DB01064 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm800222k
1499 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm8000345
3779 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm8000345
536 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm8000345
CHEMBL434 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm8000345
DB01064 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm8000345
1499 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2004.11.001
3779 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2004.11.001
536 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2004.11.001
CHEMBL434 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2004.11.001
DB01064 2089 None 47 Human Functional pEC50 = 10.1 10.1 -58 38
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmcl.2004.11.001
11268355 96394 None 0 Human Functional pEC50 = 9.9 9.9 1 3
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 358 7 3 3 4.1 COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12 10.1016/s0960-894x(03)00073-8
CHEMBL26183 96394 None 0 Human Functional pEC50 = 9.9 9.9 1 3
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 358 7 3 3 4.1 COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12 10.1016/s0960-894x(03)00073-8
1239 1675 None 55 Guinea pig Functional pEC50 = 9.5 9.5 1 5
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
3410 1675 None 55 Guinea pig Functional pEC50 = 9.5 9.5 1 5
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
3465 1675 None 55 Guinea pig Functional pEC50 = 9.5 9.5 1 5
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
CHEMBL1256786 1675 None 55 Guinea pig Functional pEC50 = 9.5 9.5 1 5
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
DB00983 1675 None 55 Guinea pig Functional pEC50 = 9.5 9.5 1 5
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1021/jm801016j
24936881 17515 None 0 Human Functional pEC50 = 9.2 9.2 1 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 476 8 3 8 4.1 Oc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1 10.1016/j.bmcl.2010.08.039
CHEMBL1257913 17515 None 0 Human Functional pEC50 = 9.2 9.2 1 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 476 8 3 8 4.1 Oc1cccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)c1 10.1016/j.bmcl.2010.08.039
12065 627 None 26 Human Functional pEC50 = 9.2 9.2 -6 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O 10.1016/j.bmcl.2009.10.013
45483813 627 None 26 Human Functional pEC50 = 9.2 9.2 -6 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O 10.1016/j.bmcl.2009.10.013
CHEMBL579394 627 None 26 Human Functional pEC50 = 9.2 9.2 -6 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O 10.1016/j.bmcl.2009.10.013
164622827 188562 None 0 Human Functional pEC50 = 9.2 9.2 -26 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4868585 188562 None 0 Human Functional pEC50 = 9.2 9.2 -26 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028721 188562 None 0 Human Functional pEC50 = 9.2 9.2 -26 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
9891927 184195 None 9 Guinea pig Functional pEC50 = 9.1 9.1 -5 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL446840 184195 None 9 Guinea pig Functional pEC50 = 9.1 9.1 -5 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL483200 184195 None 9 Guinea pig Functional pEC50 = 9.1 9.1 -5 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL483201 184195 None 9 Guinea pig Functional pEC50 = 9.1 9.1 -5 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
45483810 197142 None 0 Human Functional pEC50 = 9.1 9.1 -3 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 356 6 4 5 2.4 CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL567863 197142 None 0 Human Functional pEC50 = 9.1 9.1 -3 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 356 6 4 5 2.4 CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
123686 1979 None 51 Human Functional pEC50 = 9.1 9.1 74 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 354 9 4 5 1.7 C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O 10.1021/jm400348g
12581 1979 None 51 Human Functional pEC50 = 9.1 9.1 74 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 354 9 4 5 1.7 C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O 10.1021/jm400348g
CHEMBL11268 1979 None 51 Human Functional pEC50 = 9.1 9.1 74 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 354 9 4 5 1.7 C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2C#N)O 10.1021/jm400348g
1499 2089 None 47 Human Functional pEC50 = 9.1 9.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm9000709
3779 2089 None 47 Human Functional pEC50 = 9.1 9.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm9000709
536 2089 None 47 Human Functional pEC50 = 9.1 9.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm9000709
CHEMBL434 2089 None 47 Human Functional pEC50 = 9.1 9.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm9000709
DB01064 2089 None 47 Human Functional pEC50 = 9.1 9.1 -58 38
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassayAgonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm9000709
164623105 188566 None 0 Human Functional pEC50 = 9.1 9.1 -47 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4862449 188566 None 0 Human Functional pEC50 = 9.1 9.1 -47 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028738 188566 None 0 Human Functional pEC50 = 9.1 9.1 -47 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
13345218 197219 None 0 Human Functional pEC50 = 9.1 9.1 -8 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 372 6 5 6 2.1 CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL568272 197219 None 0 Human Functional pEC50 = 9.1 9.1 -8 2
Agonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 1 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 372 6 5 6 2.1 CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
44392175 131792 None 0 Human Functional pEC50 = 9.1 9.1 1 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 480 12 5 7 3.2 O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc([N+](=O)[O-])c1 10.1016/j.bmcl.2004.11.001
CHEMBL369346 131792 None 0 Human Functional pEC50 = 9.1 9.1 1 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 480 12 5 7 3.2 O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc([N+](=O)[O-])c1 10.1016/j.bmcl.2004.11.001
1499 2089 None 47 Human Functional pEC50 = 9 9.0 -58 38
Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
3779 2089 None 47 Human Functional pEC50 = 9 9.0 -58 38
Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
536 2089 None 47 Human Functional pEC50 = 9 9.0 -58 38
Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
CHEMBL434 2089 None 47 Human Functional pEC50 = 9 9.0 -58 38
Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
DB01064 2089 None 47 Human Functional pEC50 = 9 9.0 -58 38
Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells.
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
1499 2089 None 47 Human Functional pEC50 = 9 9.0 -58 38
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
3779 2089 None 47 Human Functional pEC50 = 9 9.0 -58 38
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
536 2089 None 47 Human Functional pEC50 = 9 9.0 -58 38
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
CHEMBL434 2089 None 47 Human Functional pEC50 = 9 9.0 -58 38
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
DB01064 2089 None 47 Human Functional pEC50 = 9 9.0 -58 38
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
1499 2089 None 47 Human Functional pEC50 = 8.9 8.9 -58 38
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
3779 2089 None 47 Human Functional pEC50 = 8.9 8.9 -58 38
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
536 2089 None 47 Human Functional pEC50 = 8.9 8.9 -58 38
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
CHEMBL434 2089 None 47 Human Functional pEC50 = 8.9 8.9 -58 38
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
DB01064 2089 None 47 Human Functional pEC50 = 8.9 8.9 -58 38
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
44392230 65595 None 1 Human Functional pEC50 = 8.9 8.9 1 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 479 12 6 6 3.0 O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc(C(=O)O)c1 10.1016/j.bmcl.2004.11.001
CHEMBL183283 65595 None 1 Human Functional pEC50 = 8.9 8.9 1 2
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptorAgonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
ChEMBL 479 12 6 6 3.0 O=C(Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1)Nc1cccc(C(=O)O)c1 10.1016/j.bmcl.2004.11.001
24822304 97862 None 0 Human Functional pEC50 = 8.9 8.9 6 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 412 9 3 5 4.1 O=C(O)c1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)nc1 10.1021/jm701324c
CHEMBL272234 97862 None 0 Human Functional pEC50 = 8.9 8.9 6 2
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIAAgonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA
ChEMBL 412 9 3 5 4.1 O=C(O)c1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)nc1 10.1021/jm701324c
105 3459 None 91 Human Functional pEC50 = 8.8 8.8 -28 3
Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
2083 3459 None 91 Human Functional pEC50 = 8.8 8.8 -28 3
Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
558 3459 None 91 Human Functional pEC50 = 8.8 8.8 -28 3
Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
CHEMBL714 3459 None 91 Human Functional pEC50 = 8.8 8.8 -28 3
Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
DB01001 3459 None 91 Human Functional pEC50 = 8.8 8.8 -28 3
Agonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta1 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
164615126 188502 None 0 Human Functional pEC50 = 8.8 8.8 -104 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4854569 188502 None 0 Human Functional pEC50 = 8.8 8.8 -104 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028293 188502 None 0 Human Functional pEC50 = 8.8 8.8 -104 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
90645347 112511 None 0 Human Functional pEC50 = 8.8 8.8 -7 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 578 12 6 7 5.6 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298987 112511 None 0 Human Functional pEC50 = 8.8 8.8 -7 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 578 12 6 7 5.6 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.095
164618895 188533 None 0 Human Functional pEC50 = 8.8 8.8 -95 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4868938 188533 None 0 Human Functional pEC50 = 8.8 8.8 -95 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028525 188533 None 0 Human Functional pEC50 = 8.8 8.8 -95 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
45101519 198521 None 0 Human Functional pEC50 = 8.7 8.7 -1 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 498 11 8 7 1.6 CC(C)(Cc1ccc(NC(=O)CCCNC(=N)N)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
CHEMBL577917 198521 None 0 Human Functional pEC50 = 8.7 8.7 -1 2
Agonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP levelAgonist activity at human beta-1 adrenoceptor expressed in CHOK1 cell assessed as increase of intracellular cAMP level
ChEMBL 498 11 8 7 1.6 CC(C)(Cc1ccc(NC(=O)CCCNC(=N)N)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.06.104
24936492 17547 None 0 Human Functional pEC50 = 8.7 8.7 -1 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 482 8 3 9 4.1 Oc1ccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5cccs5)c34)CC2)cc1 10.1016/j.bmcl.2010.08.039
CHEMBL1258026 17547 None 0 Human Functional pEC50 = 8.7 8.7 -1 3
Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayAgonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assay
ChEMBL 482 8 3 9 4.1 Oc1ccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5cccs5)c34)CC2)cc1 10.1016/j.bmcl.2010.08.039
164612078 188476 None 0 Human Functional pEC50 = 8.7 8.7 -64 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4848617 188476 None 0 Human Functional pEC50 = 8.7 8.7 -64 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028119 188476 None 0 Human Functional pEC50 = 8.7 8.7 -64 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
9927453 96685 None 0 Human Functional pEC50 = 8.7 8.7 -1 3
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 328 6 3 2 4.1 C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
CHEMBL26393 96685 None 0 Human Functional pEC50 = 8.7 8.7 -1 3
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-ARAgonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR
ChEMBL 328 6 3 2 4.1 C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1 10.1016/s0960-894x(03)00073-8
42625513 12557 None 0 Guinea pig Functional pEC50 = 8.7 8.7 -3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1021/jm801016j
CHEMBL1186722 12557 None 0 Guinea pig Functional pEC50 = 8.7 8.7 -3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1021/jm801016j
CHEMBL475389 12557 None 0 Guinea pig Functional pEC50 = 8.7 8.7 -3 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1ccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc1 10.1021/jm801016j
90645346 112493 None 0 Human Functional pEC50 = 8.7 8.7 -2 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 578 13 6 7 4.7 O=C(NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1)c1ccccc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298762 112493 None 0 Human Functional pEC50 = 8.7 8.7 -2 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 578 13 6 7 4.7 O=C(NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1)c1ccccc1 10.1016/j.bmcl.2014.04.095
42625517 12719 None 0 Guinea pig Functional pEC50 = 8 8.0 -19 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 536 19 5 7 3.8 CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL1187654 12719 None 0 Guinea pig Functional pEC50 = 8 8.0 -19 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 536 19 5 7 3.8 CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL514032 12719 None 0 Guinea pig Functional pEC50 = 8 8.0 -19 4
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contractionAgonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
ChEMBL 536 19 5 7 3.8 CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
11180293 112506 None 0 Human Functional pEC50 = 8 8.0 -22 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 543 12 6 8 3.1 O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmcl.2014.04.095
CHEMBL3298897 112506 None 0 Human Functional pEC50 = 8 8.0 -22 3
Agonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta1 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 543 12 6 8 3.1 O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmcl.2014.04.095
56668796 66600 None 0 Human Functional pEC50 = 8 8.0 -31 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 598 20 7 7 4.3 O=C(CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCC1 10.1016/j.bmc.2011.08.043
CHEMBL1835860 66600 None 0 Human Functional pEC50 = 8 8.0 -31 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 598 20 7 7 4.3 O=C(CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCC1 10.1016/j.bmc.2011.08.043
CHEMBL1852632 66600 None 0 Human Functional pEC50 = 8 8.0 -31 3
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 598 20 7 7 4.3 O=C(CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NC1CCCC1 10.1016/j.bmc.2011.08.043
45273268 195627 None 0 Human Functional pEC50 = 8 8.0 194 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 362 10 3 4 4.0 O[C@@H](CNCCc1ccc(Nc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL1204004 195627 None 0 Human Functional pEC50 = 8 8.0 194 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 362 10 3 4 4.0 O[C@@H](CNCCc1ccc(Nc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
CHEMBL556274 195627 None 0 Human Functional pEC50 = 8 8.0 194 2
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenolAgonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay relative to isoproterenol
ChEMBL 362 10 3 4 4.0 O[C@@H](CNCCc1ccc(Nc2ccccc2)cc1)COc1ccccc1 10.1016/j.bmc.2009.06.031
10217757 112268 None 0 Human Functional pEC50 = 8 8.0 -31 4
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 497 12 5 6 5.2 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.069
CHEMBL3290998 112268 None 0 Human Functional pEC50 = 8 8.0 -31 4
Agonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta1 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 497 12 5 6 5.2 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.069
164614147 188490 None 0 Human Functional pEC50 = 8.0 8.0 - 1
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4856990 188490 None 0 Human Functional pEC50 = 8.0 8.0 - 1
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028233 188490 None 0 Human Functional pEC50 = 8.0 8.0 - 1
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164618813 188532 None 0 Human Functional pEC50 = 8.0 8.0 -275 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL4865833 188532 None 0 Human Functional pEC50 = 8.0 8.0 -275 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL5028523 188532 None 0 Human Functional pEC50 = 8.0 8.0 -275 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
164619360 188536 None 0 Human Functional pEC50 = 8.0 8.0 -371 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4868763 188536 None 0 Human Functional pEC50 = 8.0 8.0 -371 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028547 188536 None 0 Human Functional pEC50 = 8.0 8.0 -371 2
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
155774 4094 None 40 Human Functional pEC50 = 8.0 8.0 42 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
2848 4094 None 40 Human Functional pEC50 = 8.0 8.0 42 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
538 4094 None 40 Human Functional pEC50 = 8.0 8.0 42 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
CHEMBL75753 4094 None 40 Human Functional pEC50 = 8.0 8.0 42 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
DB13781 4094 None 40 Human Functional pEC50 = 8.0 8.0 42 3
Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsPartial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
ChEMBL 339 8 4 6 -0.2 OC(COc1ccc(cc1)O)CNCCNC(=O)N1CCOCC1 10.1021/jm400348g
10863093 50325 None 0 Human Functional pEC50 = 7 7.0 -19 3
Ability to cause cAMP accumula