Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Unit Assay Type Assay Description Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles
CHEMBL413212 mc3r_human Human No 10.2 EC50 = 0.1 Funct
Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor
1059 17 13 11 0.7 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=C(C=C3)Cl)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
CHEMBL429236 mc3r_mouse Mouse No 10.0 EC50 = 0.1 Funct
Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor
1310 40 16 16 -2.3 CCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)C)C(=O)N)NC(=O)C
CHEMBL216295 mc3r_mouse Mouse No 9.8 EC50 = 0.2 Funct
Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor
1040 16 13 13 0.3 CC(C)CC(C(=O)NC1CC(=O)ONCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
CHEMBL386081 mc3r_mouse Mouse No 9.8 EC50 = 0.2 Funct
Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor
1451 46 21 20 -4.6 CCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)NC(CCCCN)C(=O)N)NC(=O)C(CO)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CO)NC(=O)C
CHEMBL386583 mc3r_mouse Mouse No 9.8 EC50 = 0.2 Funct
In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.
1025 21 12 13 -1.9 CCCCC(C(=O)N1C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1=O)CCCCN)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5)CC(=O)O)NC(=O)C
CHEMBL428615 mc3r_human Human No 9.7 EC50 = 0.2 Funct
Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor
1042 17 13 12 0.1 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=C(C=C3)F)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
CHEMBL3358549 mc3r_mouse Mouse No 9.7 EC50 = 0.2 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CCN2C=C(CCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358546 mc3r_mouse Mouse No 9.7 EC50 = 0.2 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CCCCC2=CN(CC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358549 mc3r_mouse Mouse No 9.7 EC50 = 0.2 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CCN2C=C(CCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358546 mc3r_mouse Mouse No 9.7 EC50 = 0.2 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CCCCC2=CN(CC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358545 mc3r_mouse Mouse No 9.7 EC50 = 0.2 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CCCC2=CN(CCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL2371851 mc3r_mouse Mouse No 9.7 EC50 = 0.2 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
1025 21 12 13 -1.9 CCCCC(C(=O)N1C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1=O)CCCCN)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5)CC(=O)O)NC(=O)C
CHEMBL3358545 mc3r_mouse Mouse No 9.7 EC50 = 0.2 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CCCC2=CN(CCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL2371851 mc3r_mouse Mouse No 9.7 EC50 = 0.2 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
1025 21 12 13 -1.9 CCCCC(C(=O)N1C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1=O)CCCCN)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5)CC(=O)O)NC(=O)C
CHEMBL3629347 mc3r_mouse Mouse No 9.7 EC50 = 0.2 Funct
Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assay
1647 51 23 22 -3.5 CCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C
CHEMBL3629347 mc3r_mouse Mouse No 9.7 EC50 = 0.2 Funct
Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells by AlphaScreen cAMP assay
1647 51 23 22 -3.5 CCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C
CHEMBL3629347 mc3r_mouse Mouse No 9.6 EC50 = 0.2 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay
1647 51 23 22 -3.5 CCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C
CHEMBL3629347 mc3r_mouse Mouse No 9.6 EC50 = 0.2 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 2 hrs by cAMP alpha screen assay
1647 51 23 22 -3.5 CCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C
CHEMBL405087 mc3r_rat Rat No 9.6 EC50 = 0.2 Funct
Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)
1096 18 14 14 -0.6 CC(C(C(=O)N)NC(=O)C1CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5)NC(=O)C(CC6=CC=CC=C6)N)O
CHEMBL414965 mc3r_rat Rat No 9.6 EC50 = 0.2 Funct
Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)
1117 18 15 13 -0.9 CC(C(C(=O)N)NC(=O)C1CCCCNC(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5)NC(=O)C(CC6=CC=CC=C6)N)O
CHEMBL267794 mc3r_mouse Mouse No 9.6 EC50 = 0.3 Funct
Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor
928 28 12 11 0.4 CCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N)NC(=O)C
CHEMBL3358552 mc3r_mouse Mouse No 9.5 EC50 = 0.3 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1034 17 12 12 0.1 CCCCC(C(=O)NC1CCN2C=C(CCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358544 mc3r_mouse Mouse No 9.5 EC50 = 0.3 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CCC2=CN(CCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358552 mc3r_mouse Mouse No 9.5 EC50 = 0.3 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1034 17 12 12 0.1 CCCCC(C(=O)NC1CCN2C=C(CCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358544 mc3r_mouse Mouse No 9.5 EC50 = 0.3 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CCC2=CN(CCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL410763 mc3r_mouse Mouse No 9.5 EC50 = 0.3 Funct
Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor
1265 38 18 17 -1.2 CCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N)NC(=O)C(CO)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CO)NC(=O)C
CHEMBL405282 mc3r_human Human Yes 9.5 EC50 = 0.3 Funct
Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)
1571 49 23 21 -1.6 CC(C)C(C(=O)NC(CCSC)C(=O)NCC(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)O)NC(=O)C(CC6=CC=C(C=C6)O)N
CHEMBL405282 mc3r_human Human Yes 9.5 EC50 = 0.3 Funct
Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor
1571 49 23 21 -1.6 CC(C)C(C(=O)NC(CCSC)C(=O)NCC(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)O)NC(=O)C(CC6=CC=C(C=C6)O)N
CHEMBL413912 mc3r_human Human No 9.4 EC50 = 0.4 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
1647 49 22 22 -4.0 CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C
CHEMBL413912 mc3r_human Human No 9.4 EC50 = 0.4 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
1647 49 22 22 -4.0 CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)NC(=O)C
CHEMBL264536 mc3r_mouse Mouse No 9.4 EC50 = 0.4 Funct
Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor
985 30 13 12 -0.2 CCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCC(=O)N)NC(=O)C
CHEMBL212614 mc3r_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
737 16 6 7 1.7 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCN(C(=O)C3CCCN=C(N)N)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL212614 mc3r_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
737 16 6 7 1.7 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCN(C(=O)C3CCCN=C(N)N)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL3358541 mc3r_mouse Mouse No 9.4 EC50 = 0.4 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1038 33 12 12 3.0 CCCCC(C(=O)N)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CN=CN4)NC(=O)C(CCN=[N+]=[N-])NC(=O)C(CCCC)NC(=O)C
CHEMBL3358541 mc3r_mouse Mouse No 9.4 EC50 = 0.4 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1038 33 12 12 3.0 CCCCC(C(=O)N)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CN=CN4)NC(=O)C(CCN=[N+]=[N-])NC(=O)C(CCCC)NC(=O)C
CHEMBL215833 mc3r_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
746 17 6 8 0.8 CC(=O)NC(CCC(=O)N)C(=O)NC(CC1=CC=C(C=C1)F)C(=O)N2CCN(C(=O)C2CCCN=C(N)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL215833 mc3r_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
746 17 6 8 0.8 CC(=O)NC(CCC(=O)N)C(=O)NC(CC1=CC=C(C=C1)F)C(=O)N2CCN(C(=O)C2CCCN=C(N)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL3358550 mc3r_mouse Mouse No 9.2 EC50 = 0.6 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CN2C=C(CCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358550 mc3r_mouse Mouse No 9.2 EC50 = 0.6 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CN2C=C(CCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358551 mc3r_mouse Mouse No 9.2 EC50 = 0.6 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1034 17 12 12 0.1 CCCCC(C(=O)NC1CCC2=CN(CCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358551 mc3r_mouse Mouse No 9.2 EC50 = 0.6 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1034 17 12 12 0.1 CCCCC(C(=O)NC1CCC2=CN(CCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL408257 mc3r_human Human Yes 9.2 EC50 = 0.7 Funct
Agonist activity at human Melanocortin-3 receptor as peptide required for 50% maximal cAMP releaseAgonist activity at human Melanocortin-3 receptor as peptide required for 50% maximal cAMP release
1175 21 16 16 -3.0 CC(=O)NC(CCCN=C(N)N)C(=O)NC1CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCC(=O)O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL408257 mc3r_human Human Yes 9.2 EC50 = 0.7 Funct
Agonist activity at human Melanocortin-3 receptor as peptide required for 50% maximal cAMP releaseAgonist activity at human Melanocortin-3 receptor as peptide required for 50% maximal cAMP release
1175 21 16 16 -3.0 CC(=O)NC(CCCN=C(N)N)C(=O)NC1CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCC(=O)O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL3358539 mc3r_mouse Mouse No 9.1 EC50 = 0.9 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1052 34 12 12 3.5 CCCCCC(C(=O)N)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CN=CN4)NC(=O)C(CCN=[N+]=[N-])NC(=O)C(CCCC)NC(=O)C
CHEMBL3358539 mc3r_mouse Mouse No 9.1 EC50 = 0.9 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1052 34 12 12 3.5 CCCCCC(C(=O)N)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CN=CN4)NC(=O)C(CCN=[N+]=[N-])NC(=O)C(CCCC)NC(=O)C
CHEMBL3358535 mc3r_mouse Mouse No 9.0 EC50 = 0.9 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1052 34 12 12 3.5 CCCCCC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CCN=[N+]=[N-])C(=O)N)NC(=O)C(CCCC)NC(=O)C
CHEMBL3358535 mc3r_mouse Mouse No 9.0 EC50 = 0.9 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1052 34 12 12 3.5 CCCCCC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CCN=[N+]=[N-])C(=O)N)NC(=O)C(CCCC)NC(=O)C
CHEMBL2369959 mc3r_mouse Mouse No 9.0 EC50 = 1.0 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1487 23 19 19 -2.8 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL2369959 mc3r_mouse Mouse No 9.0 EC50 = 1.0 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1487 23 19 19 -2.8 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL2369484 mc3r_mouse Mouse No 9.0 EC50 = 1.0 Funct
Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor
1529 24 22 22 -3.2 CC1C(=O)NC(C(=O)NC(NC(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NNC6CC7=C(C=C(C=C7)O)NC6=O)C(=O)NNC(CC8=CC=C(C=C8)O)C(=O)C(=O)O)CC9=CC=CC=C9
CHEMBL379054 mc3r_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
763 16 6 7 3.1 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCN(C(=O)C3CCCN=C(N)N)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL379054 mc3r_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
763 16 6 7 3.1 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CCN(C(=O)C3CCCN=C(N)N)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL2372859 mc3r_mouse Mouse No 9.0 EC50 = 1.1 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1042 33 14 13 -2.7 CCCCC(C(=O)NC(CC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CCCCN)C(=O)N)NC(=O)C
CHEMBL2372859 mc3r_mouse Mouse No 9.0 EC50 = 1.1 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1042 33 14 13 -2.7 CCCCC(C(=O)NC(CC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CCCCN)C(=O)N)NC(=O)C
CHEMBL428801 mc3r_human Human No 9.0 EC50 = 1.1 Funct
Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor
1150 17 13 11 0.7 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=C(C=C3)I)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
CHEMBL263822 mc3r_human Human Yes 8.9 EC50 = 1.2 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
887 16 12 9 -0.3 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CCCN=C(N)N
CHEMBL263822 mc3r_human Human Yes 8.9 EC50 = 1.2 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
887 16 12 9 -0.3 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CCCN=C(N)N
CHEMBL377465 mc3r_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
653 15 5 6 2.6 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL377465 mc3r_human Human No 8.9 EC50 = 1.3 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
653 15 5 6 2.6 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL3358540 mc3r_mouse Mouse No 8.9 EC50 = 1.3 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1052 34 12 12 3.7 CCCCCCC(C(=O)N)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CN=CN4)NC(=O)C(CN=[N+]=[N-])NC(=O)C(CCCC)NC(=O)C
CHEMBL3358540 mc3r_mouse Mouse No 8.9 EC50 = 1.3 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1052 34 12 12 3.7 CCCCCCC(C(=O)N)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CN=CN4)NC(=O)C(CN=[N+]=[N-])NC(=O)C(CCCC)NC(=O)C
CHEMBL3600920 mc3r_human Human No 8.8 EC50 = 1.5 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1116 17 10 11 1.8 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(N(C(=O)C(N(C(=O)C(N(C(=O)C(NC1=O)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL3600920 mc3r_human Human No 8.8 EC50 = 1.5 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1116 17 10 11 1.8 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(N(C(=O)C(N(C(=O)C(N(C(=O)C(NC1=O)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL3358536 mc3r_mouse Mouse No 8.8 EC50 = 1.6 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1052 34 12 12 3.7 CCCCCCC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CN=[N+]=[N-])C(=O)N)NC(=O)C(CCCC)NC(=O)C
CHEMBL3358536 mc3r_mouse Mouse No 8.8 EC50 = 1.6 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1052 34 12 12 3.7 CCCCCCC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CN=[N+]=[N-])C(=O)N)NC(=O)C(CCCC)NC(=O)C
CHEMBL439691 mc3r_human Human No 8.8 EC50 = 1.6 Funct
Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)
1568 48 21 21 -2.0 CCCCC(C(=O)NCC(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(=O)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)ON)NC(=O)C(C(C)C)NC(=O)C(CC6=CC=C(C=C6)O)N
CHEMBL438030 mc3r_human Human No 8.8 EC50 = 1.6 Funct
Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.
1552 47 21 19 -2.2 CCCCC(C(=O)NCC(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(=O)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC6=CC=C(C=C6)O)N
CHEMBL267900 mc3r_human Human Yes 8.8 EC50 = 1.6 Funct
Agonist activity at human Melanocortin-3 receptor as peptide required for 50% maximal cAMP releaseAgonist activity at human Melanocortin-3 receptor as peptide required for 50% maximal cAMP release
1175 21 16 16 -3.0 CC(=O)NC(CCCN=C(N)N)C(=O)NC1CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCC(=O)O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL267900 mc3r_human Human Yes 8.8 EC50 = 1.6 Funct
Agonist activity at human Melanocortin-3 receptor as peptide required for 50% maximal cAMP releaseAgonist activity at human Melanocortin-3 receptor as peptide required for 50% maximal cAMP release
1175 21 16 16 -3.0 CC(=O)NC(CCCN=C(N)N)C(=O)NC1CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCC(=O)O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL1688107 mc3r_mouse Mouse No 8.8 EC50 = 1.7 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1507 24 20 19 0.6 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCNC(=N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)N)CC8=CC=CC=C8
CHEMBL393075 mc3r_human Human No 8.7 EC50 = 1.9 Funct
Effect on human MC3R expressed in HEK293 cells assessed as intracellular cAMP accumulationEffect on human MC3R expressed in HEK293 cells assessed as intracellular cAMP accumulation
1032 16 13 11 1.0 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N
CHEMBL393075 mc3r_human Human No 8.7 EC50 = 1.9 Funct
Effect on human MC3R expressed in HEK293 cells assessed as intracellular cAMP accumulationEffect on human MC3R expressed in HEK293 cells assessed as intracellular cAMP accumulation
1032 16 13 11 1.0 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N
CHEMBL2370154 mc3r_human Human No 8.7 EC50 = 1.9 Funct
Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells
1038 17 13 11 0.4 CCCCC(C(=O)NC1CC(=O)NCCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
CHEMBL3752534 mc3r_human Human No 8.7 EC50 = 1.9 Funct
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX
1131 15 11 11 1.9 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2CCCN2C(=O)C3CCCN3C1=O)CC4=CC5=CC=CC=C5C=C4)CCCN=C(N)N)CC6=CNC7=CC=CC=C76)C(=O)N)NC(=O)C
CHEMBL3752534 mc3r_human Human No 8.7 EC50 = 1.9 Funct
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX
1131 15 11 11 1.9 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2CCCN2C(=O)C3CCCN3C1=O)CC4=CC5=CC=CC=C5C=C4)CCCN=C(N)N)CC6=CNC7=CC=CC=C76)C(=O)N)NC(=O)C
CHEMBL3358548 mc3r_mouse Mouse No 8.7 EC50 = 1.9 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CCCN2C=C(CCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358548 mc3r_mouse Mouse No 8.7 EC50 = 1.9 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CCCN2C=C(CCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358537 mc3r_mouse Mouse No 8.7 EC50 = 1.9 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 33 12 12 2.5 CCCCC(C(=O)NC(CCCCN=[N+]=[N-])C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC#C)C(=O)N)NC(=O)C
CHEMBL3358537 mc3r_mouse Mouse No 8.7 EC50 = 1.9 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 33 12 12 2.5 CCCCC(C(=O)NC(CCCCN=[N+]=[N-])C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC#C)C(=O)N)NC(=O)C
CHEMBL384176 mc3r_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
618 12 4 6 2.3 CC(=O)NC(CC1=CC=C(C=C1)F)C(=O)N2CCN(C(=O)C2CCCN=C(N)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL209622 mc3r_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
588 14 5 6 1.1 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)N)N)OCC3=CC4=CC=CC=C4C=C3
CHEMBL384176 mc3r_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
618 12 4 6 2.3 CC(=O)NC(CC1=CC=C(C=C1)F)C(=O)N2CCN(C(=O)C2CCCN=C(N)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL209622 mc3r_human Human No 8.0 EC50 = 10 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
588 14 5 6 1.1 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)N)N)OCC3=CC4=CC=CC=C4C=C3
CHEMBL3798421 mc3r_mouse Mouse No 8.0 EC50 = 10.1 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
1631 56 21 19 0.4 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NC(CC5=CN=CN5)C(=O)NC(CC6=CC=CC=C6)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC7=CNC8=CC=CC=C87)C(=O)N
CHEMBL3798421 mc3r_mouse Mouse No 8.0 EC50 = 10.1 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
1631 56 21 19 0.4 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NC(CC5=CN=CN5)C(=O)NC(CC6=CC=CC=C6)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC7=CNC8=CC=CC=C87)C(=O)N
CHEMBL400866 mc3r_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation
812 9 9 8 0.3 C1CCNC(=O)C=CC(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1)C(=O)N)CC3=CNC4=CC=CC=C43)CCCN=C(N)N)CC5=CC=CC=C5
CHEMBL400866 mc3r_human Human No 7.0 EC50 = 100 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation
812 9 9 8 0.3 C1CCNC(=O)C=CC(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1)C(=O)N)CC3=CNC4=CC=CC=C43)CCCN=C(N)N)CC5=CC=CC=C5
CHEMBL411359 mc3r_human Human Yes 6.0 EC50 = 1000 Funct
Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)
1553 49 23 20 -0.8 CCCCC(C(=O)NCC(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CC6=CC=C(C=C6)O)N
CHEMBL315397 mc3r_human Human No 6.0 EC50 = 1000 Funct
Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells
769 7 9 8 0.6 CC1C(=O)NC(C(=O)NC(CCCCNC(=O)CCC(=O)NC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)CC3=CN=CN3)C(=O)N)CC4=CNC5=CC=CC=C54
CHEMBL63850 mc3r_mouse Mouse No 4.0 EC50 = 100000 Funct
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells
491 11 5 4 2.7 C1CN(CCC1CC2=CC=CC=C2)NC(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCCCCN
CHEMBL64954 mc3r_mouse Mouse No 4.0 EC50 = 100000 Funct
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells
408 10 5 3 1.9 C1=CC=C(C=C1)CNC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCCCCN
CHEMBL249277 mc3r_human Human No 6.0 EC50 = 1001 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
606 12 2 6 6.3 CCCCCCC1(CCN(CC1)C(=O)C(CC2=CC=C(C=C2)Cl)NC(=O)C3CC4=CC=CC=C4CN3)CC5=NN=NN5C
CHEMBL249277 mc3r_human Human No 6.0 EC50 = 1001 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
606 12 2 6 6.3 CCCCCCC1(CCN(CC1)C(=O)C(CC2=CC=C(C=C2)Cl)NC(=O)C3CC4=CC=CC=C4CN3)CC5=NN=NN5C
CHEMBL187167 mc3r_human Human No 6.0 EC50 = 1013 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
773 20 9 7 1.2 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CC(=O)N
CHEMBL187167 mc3r_human Human No 6.0 EC50 = 1013 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
773 20 9 7 1.2 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CC(=O)N
CHEMBL362879 mc3r_human Human No 6.0 EC50 = 1016 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
776 20 8 7 2.8 CSCC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL362879 mc3r_human Human No 6.0 EC50 = 1016 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
776 20 8 7 2.8 CSCC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL194217 mc3r_mouse Mouse No 7.0 EC50 = 102 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
812 27 9 7 4.6 CCCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL194217 mc3r_mouse Mouse No 7.0 EC50 = 102 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
812 27 9 7 4.6 CCCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL449131 mc3r_human Human No 7.0 EC50 = 103 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
624 11 2 6 4.9 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3=CC=NC=C3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL449131 mc3r_human Human No 7.0 EC50 = 103 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
624 11 2 6 4.9 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3=CC=NC=C3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL432201 mc3r_mouse Mouse No 5.0 EC50 = 10300 Funct
In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.
735 18 9 6 1.9 CC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL2323791 mc3r_mouse Mouse Yes 5.0 EC50 = 10350 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1586 22 21 32 4.0 CC1C(=NC(C(=NC(CSSCC(C(=NC(C(=O)N2CCCC2C(=NC3CSCC(=O)N(CC(N=C3O)CCCNC(=N)N)C(C(=NC(C(=N1)O)CC(=N)O)O)CC4=CNC5=CC=CC=C54)O)CC6=CN=CN6)O)N=C(C(CC7=CC=C(C=C7)O)N)O)C(=NC(CC8=CC=C(C=C8)O)C(=N)O)O)O)CC9=CC=CC=C9)O
CHEMBL3798845 mc3r_mouse Mouse No 7.0 EC50 = 107 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
1611 37 16 19 -3.2 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N5CCCC5C(=O)NCC(=O)N6CCCC6C(=O)NCC(=O)N7CCCC7C(=O)NCC(=O)N8CCCC8C(=O)NCC(=O)N9CCCC9C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N
CHEMBL1090813 mc3r_human Human No 5.0 EC50 = 10700 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
507 4 1 7 4.7 CC1CN(CC(C1(C2=C(C=C(C=C2)F)F)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C
CHEMBL1090813 mc3r_human Human No 5.0 EC50 = 10700 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
507 4 1 7 4.7 CC1CN(CC(C1(C2=C(C=C(C=C2)F)F)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C
CHEMBL2112213 mc3r_mouse Mouse No 5.0 EC50 = 10700 Funct
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells
442 8 5 3 2.6 C1=CC=C(C=C1)CNC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC4=CC=C(C=C4)CN
CHEMBL506762 mc3r_human Human No 7.0 EC50 = 108 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
630 11 3 6 4.4 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3CCNCC3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL506762 mc3r_human Human No 7.0 EC50 = 108 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
630 11 3 6 4.4 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3CCNCC3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL3600916 mc3r_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1116 17 10 11 1.8 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(N(C(=O)C(NC(=O)C(NC(=O)C(N(C1=O)C)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL3600916 mc3r_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1116 17 10 11 1.8 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(N(C(=O)C(NC(=O)C(NC(=O)C(N(C1=O)C)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL2371712 mc3r_human Human No 8.0 EC50 = 11 Funct
Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)
1589 45 18 20 0.9 CCCCC(C(=O)NCC(=O)N1CCCC1C(=O)NC(CC2=CC3=CC=CC=C3C=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)NC(CC(=O)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC6=CC=CC=C6)C(=O)NCC(=O)ON)NC(=O)C(C(C)C)NC(=O)C(CC7=CC=C(C=C7)O)N
CHEMBL3287323 mc3r_mouse Mouse No 7.9 EC50 = 11.7 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
899 18 8 7 1.2 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)I)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=C(C=C3)I)C(=O)N
CHEMBL3287323 mc3r_mouse Mouse No 7.9 EC50 = 11.7 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
899 18 8 7 1.2 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)I)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=C(C=C3)I)C(=O)N
CHEMBL453300 mc3r_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
630 11 2 7 5.4 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3=CSC=N3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL2113043 mc3r_human Human No 6.0 EC50 = 1100 Funct
Effective concentration against human melanocortin 3 receptor in cAMP release assayEffective concentration against human melanocortin 3 receptor in cAMP release assay
623 10 2 7 5.8 CC(CCC1CC(=NN(C1=O)C2=CC=C(C=C2)OC)SC3=CC=C(C=C3)Cl)NC(=O)C4CCNCC4C5=CC=C(C=C5)F
CHEMBL453300 mc3r_human Human No 6.0 EC50 = 1100 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
630 11 2 7 5.4 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3=CSC=N3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL2113043 mc3r_human Human No 6.0 EC50 = 1100 Funct
Effective concentration against human melanocortin 3 receptor in cAMP release assayEffective concentration against human melanocortin 3 receptor in cAMP release assay
623 10 2 7 5.8 CC(CCC1CC(=NN(C1=O)C2=CC=C(C=C2)OC)SC3=CC=C(C=C3)Cl)NC(=O)C4CCNCC4C5=CC=C(C=C5)F
CHEMBL466380 mc3r_human Human No 7.0 EC50 = 113 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
561 10 2 5 4.3 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL466380 mc3r_human Human No 7.0 EC50 = 113 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
561 10 2 5 4.3 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL3601426 mc3r_human Human No 6.0 EC50 = 1130 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1116 17 10 11 1.8 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(N(C(=O)C(N(C(=O)C(N(C1=O)C)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL3601426 mc3r_human Human No 6.0 EC50 = 1130 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1116 17 10 11 1.8 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(N(C(=O)C(N(C(=O)C(N(C1=O)C)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL213747 mc3r_human Human No 6.0 EC50 = 1134 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
653 15 5 6 2.6 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL213747 mc3r_human Human No 6.0 EC50 = 1134 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
653 15 5 6 2.6 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL250508 mc3r_human Human No 6.9 EC50 = 115 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
604 8 2 6 5.8 CN1C(=NN=N1)CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6CCCCC6
CHEMBL250508 mc3r_human Human No 6.9 EC50 = 115 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
604 8 2 6 5.8 CN1C(=NN=N1)CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6CCCCC6
CHEMBL1091631 mc3r_human Human No 4.9 EC50 = 11600 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
457 4 1 5 4.3 CC1CN(CC(C1(C2=CC=CC=C2)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)C
CHEMBL1091631 mc3r_human Human No 4.9 EC50 = 11600 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
457 4 1 5 4.3 CC1CN(CC(C1(C2=CC=CC=C2)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)C
CHEMBL379490 mc3r_human Human No 5.9 EC50 = 1171 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
679 15 5 6 4.1 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL379490 mc3r_human Human No 5.9 EC50 = 1171 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
679 15 5 6 4.1 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL96871 mc3r_mouse Mouse No 4.9 EC50 = 11800 Funct
In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.
708 15 7 6 1.6 CC(=O)N1CC2=CC=CC=C2CC1C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL589515 mc3r_mouse Mouse No 4.9 EC50 = 11900 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase reporter gene assay
654 17 8 6 0.8 C1=CC=C(C=C1)CC(C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N)N
CHEMBL589515 mc3r_mouse Mouse No 4.9 EC50 = 11900 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase reporter gene assay
654 17 8 6 0.8 C1=CC=C(C=C1)CC(C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N)N
CHEMBL327479 mc3r_mouse Mouse No 4.9 EC50 = 11900 Funct
In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.
696 18 8 6 1.5 CC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL446757 mc3r_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
678 11 3 6 5.5 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3CC4=CC=CC=C4CN3)C(CC5=CC6=CC=CC=C6C=C5)C(=O)NC
CHEMBL446757 mc3r_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
678 11 3 6 5.5 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3CC4=CC=CC=C4CN3)C(CC5=CC6=CC=CC=C6C=C5)C(=O)NC
CHEMBL3349030 mc3r_human Human Yes 7.9 EC50 = 12 Funct
Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor
1571 49 23 32 4.2 CC(C)C(C(=NC(CCSC)C(=NCC(=NC(CC1=CN=CN1)C(=NC(CC2=CC=CC=C2)C(=NC(CCCNC(=N)N)C(=NC(CC3=CNC4=CC=CC=C43)C(=NC(CC(=O)O)C(=NC(CCCNC(=N)N)C(=NC(CC5=CC=CC=C5)C(=NCC(=O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(CC6=CC=C(C=C6)O)N)O
CHEMBL2370967 mc3r_human Human Yes 7.9 EC50 = 12 Funct
Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.
1613 49 22 19 0.9 CCCCC(C(=O)NCC(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC3=CC=CC=C3C=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC6=CC=CC=C6)C(=O)NCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC7=CC=C(C=C7)O)N
CHEMBL86573 mc3r_human Human No 6.9 EC50 = 120 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
754 19 9 10 1.0 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)NC(=O)CC(F)(F)F
CHEMBL438259 mc3r_human Human No 5.9 EC50 = 1200 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
620 8 2 4 5.5 CN1CCN(C1=O)CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6CCCCC6
CHEMBL438259 mc3r_human Human No 5.9 EC50 = 1200 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
620 8 2 4 5.5 CN1CCN(C1=O)CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6CCCCC6
CHEMBL375559 mc3r_human Human No 5.9 EC50 = 1218 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
708 15 6 7 2.7 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3C(=O)NCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL375559 mc3r_human Human No 5.9 EC50 = 1218 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
708 15 6 7 2.7 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3C(=O)NCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL510687 mc3r_mouse Mouse No 5.9 EC50 = 1240 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
720 18 9 7 0.6 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC(=CC=C2)Cl)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL510687 mc3r_mouse Mouse No 5.9 EC50 = 1240 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
720 18 9 7 0.6 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC(=CC=C2)Cl)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL105113 mc3r_mouse Mouse No 4.9 EC50 = 12500 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
702 18 10 8 -0.4 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL105113 mc3r_mouse Mouse No 4.9 EC50 = 12500 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
702 18 10 8 -0.4 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL264190 mc3r_mouse Mouse Yes 6.9 EC50 = 126 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL264190 mc3r_mouse Mouse Yes 6.9 EC50 = 126 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL272660 mc3r_mouse Mouse No 5.9 EC50 = 1260 Funct
Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells
850 12 9 8 0.7 C1CNC(=O)CCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N(C1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CC=CC=C5
CHEMBL272660 mc3r_mouse Mouse No 5.9 EC50 = 1260 Funct
Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells
850 12 9 8 0.7 C1CNC(=O)CCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N(C1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CC=CC=C5
CHEMBL2310901 mc3r_human Human No 7.9 EC50 = 13 Funct
Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)
1524 44 18 19 0.1 CCCCC(C(=O)NCC(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)NC(CC(=O)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CC6=CC=C(C=C6)O)N
CHEMBL315356 mc3r_human Human No 7.9 EC50 = 13 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
728 19 9 7 1.4 CC(C)(C)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL314401 mc3r_human Human No 7.9 EC50 = 13 Funct
Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells
902 11 11 9 1.2 C1CCNC(=O)C2=CC=CC=C2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1)C(=O)N)CC3=CNC4=CC=CC=C43)CCCN=C(N)N)CC5=CC=CC=C5)CC6=CN=CN6
CHEMBL3600843 mc3r_human Human No 7.9 EC50 = 13.2 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1102 17 11 11 1.6 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(N(C(=O)C(N(C(=O)C(NC1=O)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL3600843 mc3r_human Human No 7.9 EC50 = 13.2 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1102 17 11 11 1.6 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(N(C(=O)C(N(C(=O)C(NC1=O)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL501592 mc3r_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
1091 16 13 11 -0.1 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2CC(CN2C1=O)N=C(N)N)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL501592 mc3r_human Human No 6.9 EC50 = 130 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
1091 16 13 11 -0.1 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2CC(CN2C1=O)N=C(N)N)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL313377 mc3r_human Human No 6.9 EC50 = 130 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
714 19 9 7 1.0 CC(C)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL2369972 mc3r_mouse Mouse No 4.9 EC50 = 13200 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1437 21 18 19 -4.0 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC3=CNC4=CC=CC=C43)CCCN=C(N)N)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL2369972 mc3r_mouse Mouse No 4.9 EC50 = 13200 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1437 21 18 19 -4.0 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC3=CNC4=CC=CC=C43)CCCN=C(N)N)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL339053 mc3r_rat Rat Yes 5.9 EC50 = 1325 Funct
Functional activity as concentration at 50% maximum cAMP accumulation in rat Melanocortin-3 receptor (rMC3R)Functional activity as concentration at 50% maximum cAMP accumulation in rat Melanocortin-3 receptor (rMC3R)
589 8 2 5 5.9 C1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)CN6C=NC=N6
CHEMBL193151 mc3r_mouse Mouse No 6.9 EC50 = 134 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
868 31 9 7 6.8 CCCCCCCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL193151 mc3r_mouse Mouse No 6.9 EC50 = 134 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
868 31 9 7 6.8 CCCCCCCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL365825 mc3r_human Human No 5.9 EC50 = 1340 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
882 19 8 11 4.6 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C5=C(C(=C(C(=C5F)F)F)F)F
CHEMBL365825 mc3r_human Human No 5.9 EC50 = 1340 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
882 19 8 11 4.6 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C5=C(C(=C(C(=C5F)F)F)F)F
CHEMBL347364 mc3r_mouse Mouse No 4.9 EC50 = 13400 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
723 19 8 7 1.5 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=C(C=C3)C4=CC=CC=C4)C(=O)N
CHEMBL2369970 mc3r_mouse Mouse No 4.9 EC50 = 13500 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1371 21 18 19 -4.5 CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CC2=CC=CC=C2)CC3=CNC=N3)NC(=O)C(CC4=CC=C(C=C4)O)N)C(CC5=CC=C(C=C5)O)C(=O)N)(C)C(=O)O)CC6=CC=CC=C6)C)CC(=O)N
CHEMBL2369970 mc3r_mouse Mouse No 4.9 EC50 = 13500 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1371 21 18 19 -4.5 CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CC2=CC=CC=C2)CC3=CNC=N3)NC(=O)C(CC4=CC=C(C=C4)O)N)C(CC5=CC=C(C=C5)O)C(=O)N)(C)C(=O)O)CC6=CC=CC=C6)C)CC(=O)N
CHEMBL217584 mc3r_human Human No 6.9 EC50 = 136.4 Funct
Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor
1095 17 14 12 -0.2 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C)C(=O)N)NC(=O)C
CHEMBL3350327 mc3r_mouse Mouse No 4.9 EC50 = 13700 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay
2327 55 32 33 -6.4 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCNC(=N)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CC(=O)O)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)CC7=CC=CC=C7
CHEMBL3350327 mc3r_mouse Mouse No 4.9 EC50 = 13700 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay
2327 55 32 33 -6.4 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCNC(=N)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CC(=O)O)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)CC7=CC=CC=C7
CHEMBL212766 mc3r_human Human No 5.9 EC50 = 1384 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
516 11 3 4 3.1 CC(=O)NC(CC1=CC=CC=C1)C(=O)N2CC(CC2CCCN=C(N)N)OCC3=CC4=CC=CC=C4C=C3
CHEMBL212766 mc3r_human Human No 5.9 EC50 = 1384 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
516 11 3 4 3.1 CC(=O)NC(CC1=CC=CC=C1)C(=O)N2CC(CC2CCCN=C(N)N)OCC3=CC4=CC=CC=C4C=C3
CHEMBL190366 mc3r_mouse Mouse No 6.9 EC50 = 139 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
840 29 9 7 5.7 CCCCCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL190366 mc3r_mouse Mouse No 6.9 EC50 = 139 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
840 29 9 7 5.7 CCCCCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL500743 mc3r_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
1041 16 13 11 -1.3 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2CC(CN2C1=O)N=C(N)N)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
CHEMBL2369983 mc3r_mouse Mouse No 7.9 EC50 = 14 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1487 23 19 19 -2.8 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL500743 mc3r_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
1041 16 13 11 -1.3 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2CC(CN2C1=O)N=C(N)N)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
CHEMBL2369983 mc3r_mouse Mouse No 7.9 EC50 = 14 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1487 23 19 19 -2.8 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL363271 mc3r_human Human No 6.9 EC50 = 140 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
884 22 8 9 3.9 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CCC(=O)C5=CC(=CC(=C5)F)F
CHEMBL363271 mc3r_human Human No 6.9 EC50 = 140 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
884 22 8 9 3.9 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CCC(=O)C5=CC(=CC(=C5)F)F
CHEMBL2096759 mc3r_human Human No 6.9 EC50 = 140 Funct
Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)
1568 48 21 21 -2.0 CCCCC(C(=O)NCC(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(=O)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)ON)NC(=O)C(C(C)C)NC(=O)C(CC6=CC=C(C=C6)O)N
CHEMBL3601432 mc3r_human Human No 5.9 EC50 = 1400 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1144 17 8 11 2.2 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(N(C(=O)C(N(C(=O)C(N(C(=O)C(N(C1=O)C)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL438118 mc3r_human Human No 5.9 EC50 = 1400 Funct
Agonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulation
1040 15 9 10 3.4 CCCCC(C(=O)CC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C2CCCN2C(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=C(C=C4)C5=CC=CC=C5)CC6=CC7=CC=CC=C7N6)C(=O)N)NC(=O)C
CHEMBL3601432 mc3r_human Human No 5.9 EC50 = 1400 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1144 17 8 11 2.2 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(N(C(=O)C(N(C(=O)C(N(C(=O)C(N(C1=O)C)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL438118 mc3r_human Human No 5.9 EC50 = 1400 Funct
Agonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulation
1040 15 9 10 3.4 CCCCC(C(=O)CC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C2CCCN2C(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=C(C=C4)C5=CC=CC=C5)CC6=CC7=CC=CC=C7N6)C(=O)N)NC(=O)C
CHEMBL339053 mc3r_human Human Yes 5.9 EC50 = 1400 Funct
In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)In vitro cAMP accumulation in HEK cells transfected with human Melanocortin 3 receptor (hMC3R)
589 8 2 5 5.9 C1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)CN6C=NC=N6
CHEMBL215576 mc3r_human Human No 6.9 EC50 = 142 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
561 11 3 5 2.8 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)N3CCN(C(C3=O)CCCN=C(N)N)C(=O)CCC4=CC=C(C=C4)F
CHEMBL215576 mc3r_human Human No 6.9 EC50 = 142 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
561 11 3 5 2.8 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)N3CCN(C(C3=O)CCCN=C(N)N)C(=O)CCC4=CC=C(C=C4)F
CHEMBL366040 mc3r_human Human No 5.8 EC50 = 1449 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
746 19 9 7 1.5 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CO
CHEMBL366040 mc3r_human Human No 5.8 EC50 = 1449 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
746 19 9 7 1.5 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CO
CHEMBL359927 mc3r_human Human No 6.8 EC50 = 145 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
772 19 8 6 3.6 CC(C)(C)C(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL359927 mc3r_human Human No 6.8 EC50 = 145 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
772 19 8 6 3.6 CC(C)(C)C(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL406985 mc3r_mouse Mouse No 5.8 EC50 = 1460 Funct
Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells
850 12 9 8 0.7 C1CC(=O)NCCN(C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C1)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)CC(=O)N
CHEMBL406985 mc3r_mouse Mouse No 5.8 EC50 = 1460 Funct
Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells
850 12 9 8 0.7 C1CC(=O)NCCN(C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C1)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)CC(=O)N
CHEMBL463047 mc3r_human Human No 6.8 EC50 = 147 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
624 11 2 6 4.9 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3=CN=CC=C3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL463047 mc3r_human Human No 6.8 EC50 = 147 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
624 11 2 6 4.9 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3=CN=CC=C3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL94369 mc3r_mouse Mouse No 4.8 EC50 = 14700 Funct
In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.
746 18 8 6 2.8 CC(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL213751 mc3r_human Human No 5.8 EC50 = 1474 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
633 12 4 5 4.3 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C3CC4=CC=CC=C4CN3)OCC5=CC6=CC=CC=C6C=C5
CHEMBL213751 mc3r_human Human No 5.8 EC50 = 1474 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
633 12 4 5 4.3 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C3CC4=CC=CC=C4CN3)OCC5=CC6=CC=CC=C6C=C5
CHEMBL462044 mc3r_human Human No 6.8 EC50 = 148 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
517 9 2 5 3.9 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)N3CCN(C(C3=O)CC=C)C(=O)C(CC4=CC=C(C=C4)F)N
CHEMBL462044 mc3r_human Human No 6.8 EC50 = 148 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
517 9 2 5 3.9 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)N3CCN(C(C3=O)CC=C)C(=O)C(CC4=CC=C(C=C4)F)N
CHEMBL184968 mc3r_human Human No 5.8 EC50 = 1481 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
788 21 8 8 3.1 CCC(=O)OC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL184968 mc3r_human Human No 5.8 EC50 = 1481 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
788 21 8 8 3.1 CCC(=O)OC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL460138 mc3r_human Human No 6.8 EC50 = 149 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
519 9 2 5 4.1 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL460138 mc3r_human Human No 6.8 EC50 = 149 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
519 9 2 5 4.1 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL379508 mc3r_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
653 15 5 6 2.6 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL379508 mc3r_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
653 15 5 6 2.6 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL307457 mc3r_mouse Mouse No 7.8 EC50 = 15.2 Funct
Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor
815 23 11 10 -0.8 CC(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL451535 mc3r_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation
909 11 11 12 0.5 C1C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2=C(S1)C=CC(=C2)[N+](=O)[O-])CC3=CN=CN3)CC4=CC=C(C=C4)N)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N
CHEMBL451535 mc3r_human Human No 6.8 EC50 = 150 Funct
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation
909 11 11 12 0.5 C1C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2=C(S1)C=CC(=C2)[N+](=O)[O-])CC3=CN=CN3)CC4=CC=C(C=C4)N)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N
CHEMBL2370965 mc3r_human Human No 6.8 EC50 = 150 Funct
Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.
1587 47 19 18 0.9 CCCCC(C(=O)NCC(=O)NC(C)(CC1=CC=CC=C1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)NC(CC(=O)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC6=CC=C(C=C6)O)N
CHEMBL154251 mc3r_mouse Mouse No 4.8 EC50 = 15000 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
647 18 8 7 -0.1 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=CC=C3)C(=O)N
CHEMBL320157 mc3r_mouse Mouse No 4.8 EC50 = 15000 Funct
In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.
646 15 7 6 0.2 CC(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL265236 mc3r_mouse Mouse No 6.8 EC50 = 154 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
882 32 9 7 7.3 CCCCCCCCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL265236 mc3r_mouse Mouse No 6.8 EC50 = 154 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
882 32 9 7 7.3 CCCCCCCCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL152612 mc3r_mouse Mouse No 6.8 EC50 = 156 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL264190 mc3r_mouse Mouse Yes 6.8 EC50 = 156 Funct
Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL264190 mc3r_mouse Mouse Yes 6.8 EC50 = 156 Funct
In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL257759 mc3r_human Human No 6.8 EC50 = 156.7 Funct
Agonist activity at human MC3R expressed in CHO cells assessed as cAMP releaseAgonist activity at human MC3R expressed in CHO cells assessed as cAMP release
572 8 1 5 5.2 CCC(C1=C(C=CC(=C1)Cl)C2CCN(CC2)C(=O)C3CN(CC3C4=C(C=C(C=C4)OC)F)C(C)(C)C)NC(=O)C
CHEMBL257759 mc3r_human Human No 6.8 EC50 = 156.7 Funct
Agonist activity at human MC3R expressed in CHO cells assessed as cAMP releaseAgonist activity at human MC3R expressed in CHO cells assessed as cAMP release
572 8 1 5 5.2 CCC(C1=C(C=CC(=C1)Cl)C2CCN(CC2)C(=O)C3CN(CC3C4=C(C=C(C=C4)OC)F)C(C)(C)C)NC(=O)C
CHEMBL188738 mc3r_human Human No 6.8 EC50 = 158.5 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
918 30 9 10 -0.6 CCCCN(CC(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)C(=O)C
CHEMBL190551 mc3r_human Human No 6.8 EC50 = 158.5 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
918 30 10 10 -0.2 CCCCC(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL188738 mc3r_human Human No 6.8 EC50 = 158.5 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
918 30 9 10 -0.6 CCCCN(CC(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)C(=O)C
CHEMBL190551 mc3r_human Human No 6.8 EC50 = 158.5 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
918 30 10 10 -0.2 CCCCC(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL3600842 mc3r_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1102 17 11 11 1.6 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(N(C(=O)C(NC(=O)C(NC(=O)C(N(C1=O)C)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL3600842 mc3r_human Human No 7.8 EC50 = 16 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1102 17 11 11 1.6 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(N(C(=O)C(NC(=O)C(NC(=O)C(N(C1=O)C)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL339053 mc3r_human Human Yes 6.8 EC50 = 160 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cellsAgonist activity at human MC3 receptor expressed in HEK293 cells
589 8 2 5 5.9 C1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)CN6C=NC=N6
CHEMBL339053 mc3r_human Human Yes 6.8 EC50 = 160 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cellsAgonist activity at human MC3 receptor expressed in HEK293 cells
589 8 2 5 5.9 C1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)CN6C=NC=N6
CHEMBL264190 mc3r_mouse Mouse Yes 6.8 EC50 = 160 Funct
Agonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cellsAgonistic activity evaluated at melanocortin 3 receptor (MC3R) of mouse HEK293 cells
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL88630 mc3r_human Human No 6.8 EC50 = 160 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
711 19 9 8 -0.1 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)NC(=O)CC#N
CHEMBL423101 mc3r_human Human No 5.8 EC50 = 1600 Funct
Agonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP releaseAgonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP release
583 8 2 5 4.1 C1CN(CCN1C2=CC=CC=C2CN3C=CN=C3)C(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C5CC6=CC=CC=C6CN5
CHEMBL358833 mc3r_mouse Mouse No 4.8 EC50 = 16000 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
723 19 8 7 1.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)N
CHEMBL184326 mc3r_human Human No 5.8 EC50 = 1604 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
812 21 8 9 3.9 COP(=S)(NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N)OC
CHEMBL184326 mc3r_human Human No 5.8 EC50 = 1604 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
812 21 8 9 3.9 COP(=S)(NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N)OC
CHEMBL3350396 mc3r_human Human No 6.8 EC50 = 161.4 Funct
Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor
1095 17 14 12 -0.2 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C)C(=O)N)NC(=O)C
CHEMBL3600836 mc3r_human Human No 6.8 EC50 = 162 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1102 17 11 11 1.6 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(N(C(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL3600836 mc3r_human Human No 6.8 EC50 = 162 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1102 17 11 11 1.6 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(N(C(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL347216 mc3r_mouse Mouse No 5.8 EC50 = 1620 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
697 18 8 7 1.1 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)N
CHEMBL348901 mc3r_mouse Mouse No 4.8 EC50 = 16200 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
723 19 8 7 1.5 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=C(C=C3)C4=CC=CC=C4)C(=O)N
CHEMBL215895 mc3r_human Human No 6.8 EC50 = 163 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
735 13 5 7 3.4 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)N3CCN(C(C3=O)CCCN=C(N)N)C(=O)C(CC4=CC=C(C=C4)F)NC(=O)C5CC6=CC=CC=C6CN5
CHEMBL215895 mc3r_human Human No 6.8 EC50 = 163 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
735 13 5 7 3.4 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)N3CCN(C(C3=O)CCCN=C(N)N)C(=O)C(CC4=CC=C(C=C4)F)NC(=O)C5CC6=CC=CC=C6CN5
CHEMBL434329 mc3r_human Human No 6.8 EC50 = 164 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
759 18 9 7 1.8 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C(=O)N
CHEMBL434329 mc3r_human Human No 6.8 EC50 = 164 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
759 18 9 7 1.8 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C(=O)N
CHEMBL500516 mc3r_mouse Mouse No 4.8 EC50 = 16400 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
701 18 10 8 -0.7 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL500516 mc3r_mouse Mouse No 4.8 EC50 = 16400 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
701 18 10 8 -0.7 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL364359 mc3r_human Human No 5.8 EC50 = 1666 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
820 19 8 11 3.5 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NS(=O)(=O)C(F)(F)F
CHEMBL364359 mc3r_human Human No 5.8 EC50 = 1666 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
820 19 8 11 3.5 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NS(=O)(=O)C(F)(F)F
CHEMBL195468 mc3r_mouse Mouse No 6.8 EC50 = 167 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
812 29 9 7 5.8 CCCCCCCCCCCCNC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL195468 mc3r_mouse Mouse No 6.8 EC50 = 167 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
812 29 9 7 5.8 CCCCCCCCCCCCNC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL567634 mc3r_mouse Mouse No 4.8 EC50 = 16800 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
614 17 7 6 1.3 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C=CC=CC3=CC=CC=C3
CHEMBL567634 mc3r_mouse Mouse No 4.8 EC50 = 16800 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
614 17 7 6 1.3 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C=CC=CC3=CC=CC=C3
CHEMBL432565 mc3r_human Human No 7.8 EC50 = 17 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
776 21 9 7 1.9 C1=CC=C(C=C1)CCC(=O)NC(CC2=CN=CN2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL183733 mc3r_human Human No 6.8 EC50 = 170 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
833 22 10 8 1.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL184895 mc3r_human Human No 6.8 EC50 = 170 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
820 21 8 6 4.0 C1=CC=C(C=C1)CCC(=O)NC(CC2=CC=C(C=C2)Cl)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL183733 mc3r_human Human No 6.8 EC50 = 170 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
833 22 10 8 1.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL184895 mc3r_human Human No 6.8 EC50 = 170 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
820 21 8 6 4.0 C1=CC=C(C=C1)CCC(=O)NC(CC2=CC=C(C=C2)Cl)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL50056 mc3r_human Human Yes 6.8 EC50 = 170 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL203602 mc3r_human Human Yes 5.8 EC50 = 1700 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
859 15 11 9 -0.3 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CCC(=O)N
CHEMBL1093304 mc3r_mouse Mouse No 5.8 EC50 = 1700 Funct
Agonist activity at mouse MC3 receptorAgonist activity at mouse MC3 receptor
600 5 1 5 5.8 CC1=C(C=C2C(=C1)C(CC23CCN(CC3)C(=O)C4CN(CC4C5=C(C=C(C=C5)F)F)C(C)(C)C)C(C)(C)NC(=O)C)Cl
CHEMBL203602 mc3r_human Human Yes 5.8 EC50 = 1700 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
859 15 11 9 -0.3 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CCC(=O)N
CHEMBL1093304 mc3r_mouse Mouse No 5.8 EC50 = 1700 Funct
Agonist activity at mouse MC3 receptorAgonist activity at mouse MC3 receptor
600 5 1 5 5.8 CC1=C(C=C2C(=C1)C(CC23CCN(CC3)C(=O)C4CN(CC4C5=C(C=C(C=C5)F)F)C(C)(C)C)C(C)(C)NC(=O)C)Cl
CHEMBL62228 mc3r_mouse Mouse No 5.8 EC50 = 1700 Funct
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells
449 9 5 4 2.4 C1CN(CC2=CC=CC=C21)NC(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCCCCN
CHEMBL446941 mc3r_human Human No 5.8 EC50 = 1700 Funct
In vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells
546 12 3 6 2.8 CCCC(=O)C1(CCN(CC1)C(=O)C(CC2=CC=C(C=C2)OC)NC(=O)C(CC3=CN=CN3)N)C4=CC=CC=C4
CHEMBL2370968 mc3r_human Human Yes 5.8 EC50 = 1700 Funct
Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.
1562 46 21 18 0.3 CCCCC(C(=O)NCC(=O)N1CCCC1C(=O)NC(CC2=CC3=CC=CC=C3C=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC6=CC=CC=C6)C(=O)NCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC7=CC=C(C=C7)O)N
CHEMBL264190 mc3r_mouse Mouse Yes 6.8 EC50 = 171 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL264190 mc3r_mouse Mouse Yes 6.8 EC50 = 171 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL302703 mc3r_mouse Mouse No 5.8 EC50 = 1730 Funct
Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL2369976 mc3r_mouse Mouse No 4.8 EC50 = 17300 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1428 19 16 18 -1.3 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC3=CNC4=CC=CC=C43)CC5=CC=CC=C5)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(CC8=CC=C(C=C8)O)C(=O)N)(C)C(=O)O)CC9=CC=CC=C9
CHEMBL2369976 mc3r_mouse Mouse No 4.8 EC50 = 17300 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1428 19 16 18 -1.3 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC3=CNC4=CC=CC=C43)CC5=CC=CC=C5)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(CC8=CC=C(C=C8)O)C(=O)N)(C)C(=O)O)CC9=CC=CC=C9
CHEMBL361252 mc3r_human Human No 6.8 EC50 = 175 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
759 18 8 6 2.2 CN(C)C(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL361252 mc3r_human Human No 6.8 EC50 = 175 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
759 18 8 6 2.2 CN(C)C(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL211798 mc3r_human Human No 5.8 EC50 = 1774 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
614 12 5 6 2.2 C1CCNC(C1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3C(=O)NCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL211798 mc3r_human Human No 5.8 EC50 = 1774 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
614 12 5 6 2.2 C1CCNC(C1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3C(=O)NCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL3600919 mc3r_human Human No 5.8 EC50 = 1790 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1116 17 10 11 1.8 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(NC(=O)C(NC(=O)C(N(C(=O)C(N(C1=O)C)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL3600919 mc3r_human Human No 5.8 EC50 = 1790 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1116 17 10 11 1.8 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(NC(=O)C(NC(=O)C(N(C(=O)C(N(C1=O)C)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL439188 mc3r_human Human No 7.8 EC50 = 18 Funct
Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells
952 11 11 9 2.4 C1CCNC(=O)C2=CC=CC=C2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1)C(=O)N)CC3=CNC4=CC=CC=C43)CCCN=C(N)N)CC5=CC6=CC=CC=C6C=C5)CC7=CN=CN7
CHEMBL2323786 mc3r_mouse Mouse Yes 6.8 EC50 = 180 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1647 24 19 21 1.8 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC2CSCC(=O)N(CC(NC2=O)CCCNC(=N)N)C(C(=O)NC(C(=O)N1)CC(=O)N)CC3=CC4=CC=CC=C4C=C3)CC5=CC=CC=C5)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)CC9=CC=CC=C9
CHEMBL1209253 mc3r_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation
597 9 0 8 4.8 CC(C)N(CC(C1CCCCC1)N2CCN(CC2)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C)S(=O)(=O)C
CHEMBL1209253 mc3r_human Human No 5.8 EC50 = 1800 Funct
Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation
597 9 0 8 4.8 CC(C)N(CC(C1CCCCC1)N2CCN(CC2)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C)S(=O)(=O)C
CHEMBL349850 mc3r_human Human No 5.8 EC50 = 1800 Funct
Agonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP releaseAgonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP release
560 8 2 5 4.3 CN(C)CC1=CC=CC=C1N2CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4
CHEMBL3600917 mc3r_human Human No 5.7 EC50 = 1810 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1116 17 10 11 1.8 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(NC(=O)C(N(C(=O)C(N(C(=O)C(NC1=O)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL3600917 mc3r_human Human No 5.7 EC50 = 1810 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1116 17 10 11 1.8 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(NC(=O)C(N(C(=O)C(N(C(=O)C(NC1=O)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL2323799 mc3r_mouse Mouse Yes 5.7 EC50 = 1830 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1650 25 20 21 1.0 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC2CSCC(=O)N(CC(NC2=O)CCCCNC(=N)N)C(C(=O)NC(C(=O)N1)CC(=O)N)CC3=CNC4=CC=CC=C43)CC5=CC=CC=C5)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)CC9=CC=CC=C9
CHEMBL3287327 mc3r_mouse Mouse No 7.7 EC50 = 19 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
807 18 8 7 1.1 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)Cl)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=C(C=C3)I)C(=O)N
CHEMBL3287327 mc3r_mouse Mouse No 7.7 EC50 = 19 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
807 18 8 7 1.1 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)Cl)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=C(C=C3)I)C(=O)N
CHEMBL438235 mc3r_human Human No 7.7 EC50 = 19 Funct
Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.
1669 35 21 20 1.0 CCCCC(C(=O)NC1C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSC1(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CC=CC=C2)C(=O)NCC(=O)N)CC3=CNC4=CC=CC=C43)CCCN=C(N)N)CC5=CC=CC=C5)CC6=CNC=N6)NC(=O)C(C(C)C)NC(=O)C(CC7=CC=C(C=C7)O)N
CHEMBL2323793 mc3r_mouse Mouse Yes 6.7 EC50 = 190 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1686 24 22 33 6.8 CC1C(=NC(C(=NC(CSSCC(C(=NC(C(=NC(C(=NC2CSCC(=O)N(CC(N=C2O)CCCNC(=N)N)C(C(=NC(C(=N1)O)CC(=N)O)O)CC3=CNC4=CC=CC=C43)O)CC5=CC=CC6=CC=CC=C65)O)CC7=CN=CN7)O)N=C(C(CC8=CC=C(C=C8)O)N)O)C(=NC(CC9=CC=C(C=C9)O)C(=N)O)O)O)CC1=CC=CC=C1)O
CHEMBL2323790 mc3r_mouse Mouse Yes 5.7 EC50 = 1900 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1596 22 20 31 5.8 CC1C(=NC(C(=NC(CSSCC(C(=O)N2CCCC2C(=NC(C(=NC3CSCC(=O)N(CC(N=C3O)CCCNC(=N)N)C(C(=NC(C(=N1)O)CC(=N)O)O)CC4=CNC5=CC=CC=C54)O)CC6=CC=CC=C6)O)N=C(C(CC7=CC=C(C=C7)O)N)O)C(=NC(CC8=CC=C(C=C8)O)C(=N)O)O)O)CC9=CC=CC=C9)O
CHEMBL264190 mc3r_mouse Mouse Yes 6.7 EC50 = 195 Funct
Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL3601431 mc3r_human Human No 5.7 EC50 = 1950 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1130 17 9 11 2.0 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(N(C(=O)C(N(C(=O)C(N(C(=O)C(N(C1=O)C)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL3601431 mc3r_human Human No 5.7 EC50 = 1950 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1130 17 9 11 2.0 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(N(C(=O)C(N(C(=O)C(N(C(=O)C(N(C1=O)C)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL568965 mc3r_mouse Mouse No 4.7 EC50 = 19500 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
658 17 7 8 1.1 C1OC2=C(O1)C=C(C=C2)C=CC=CC(=O)NC(CC3=CN=CN3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL568965 mc3r_mouse Mouse No 4.7 EC50 = 19500 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
658 17 7 8 1.1 C1OC2=C(O1)C=C(C=C2)C=CC=CC(=O)NC(CC3=CN=CN3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL431092 mc3r_mouse Mouse No 4.7 EC50 = 19800 Funct
In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.
752 18 8 7 2.8 CC(=O)NC(CC1=CSC2=CC=CC=C21)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL188459 mc3r_human Human No 5.7 EC50 = 1995.3 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 10 10 -0.7 CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC(=O)N)C(=O)C
CHEMBL188459 mc3r_human Human No 5.7 EC50 = 1995.3 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 10 10 -0.7 CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC(=O)N)C(=O)C
CHEMBL385000 mc3r_human Human No 8.7 EC50 = 2 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
781 16 6 8 3.2 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=C(C=C2)F)C(=O)N3CCN(C(=O)C3CCCN=C(N)N)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL503229 mc3r_human Human Yes 8.7 EC50 = 2 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
1594 50 23 19 1.1 CCCCC(C(=O)NCC(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C
CHEMBL504986 mc3r_human Human No 8.7 EC50 = 2 Funct
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation
894 11 10 11 1.2 C1C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2=C(S1)C=CC(=C2)[N+](=O)[O-])CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N
CHEMBL1688107 mc3r_mouse Mouse No 8.7 EC50 = 2 Funct
Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay
1507 24 20 19 0.6 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCNC(=N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)N)CC8=CC=CC=C8
CHEMBL385000 mc3r_human Human No 8.7 EC50 = 2 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
781 16 6 8 3.2 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=C(C=C2)F)C(=O)N3CCN(C(=O)C3CCCN=C(N)N)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL503229 mc3r_human Human Yes 8.7 EC50 = 2 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
1594 50 23 19 1.1 CCCCC(C(=O)NCC(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C
CHEMBL504986 mc3r_human Human No 8.7 EC50 = 2 Funct
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation
894 11 10 11 1.2 C1C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2=C(S1)C=CC(=C2)[N+](=O)[O-])CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N
CHEMBL1688107 mc3r_mouse Mouse No 8.7 EC50 = 2 Funct
Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay
1507 24 20 19 0.6 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCNC(=N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)N)CC8=CC=CC=C8
CHEMBL443071 mc3r_human Human No 8.7 EC50 = 2 Funct
Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)
1610 49 21 21 -1.7 CCCCC(C(=O)NCC(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(=O)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)ON)NC(=O)C(C(C)C)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C
CHEMBL3358533 mc3r_mouse Mouse No 8.7 EC50 = 2.2 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 33 12 12 2.5 CCCCC(C(=O)NC(CC#C)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CCCCN=[N+]=[N-])C(=O)N)NC(=O)C
CHEMBL3358533 mc3r_mouse Mouse No 8.7 EC50 = 2.2 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 33 12 12 2.5 CCCCC(C(=O)NC(CC#C)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CCCCN=[N+]=[N-])C(=O)N)NC(=O)C
CHEMBL3352878 mc3r_mouse Mouse No 8.6 EC50 = 2.3 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1038 33 12 12 3.0 CCCCC(C(=O)NC(CCCC)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CCN=[N+]=[N-])C(=O)N)NC(=O)C
CHEMBL3352878 mc3r_mouse Mouse No 8.6 EC50 = 2.3 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1038 33 12 12 3.0 CCCCC(C(=O)NC(CCCC)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CCN=[N+]=[N-])C(=O)N)NC(=O)C
CHEMBL2070241 mc3r_human Human Yes 8.6 EC50 = 2.4 Funct
Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF methodAgonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTRF method
1025 17 13 12 0.7 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)O)NC(=O)C
CHEMBL3358542 mc3r_mouse Mouse No 8.6 EC50 = 2.4 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1083 33 14 12 -0.9 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CCCCNC(=O)C)C(=O)N)NC(=O)C
CHEMBL3358542 mc3r_mouse Mouse No 8.6 EC50 = 2.4 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1083 33 14 12 -0.9 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CCCCNC(=O)C)C(=O)N)NC(=O)C
CHEMBL410949 mc3r_human Human No 8.6 EC50 = 2.8 Funct
Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation
1512 33 16 24 -6.2 CC(=O)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSC1(C)C)C(=O)N2CCCC2C(=O)CN3CCCC3C(=O)CNC(CCCCN)C(=O)CNC(CC(=O)O)C(=O)N)CC4=CNC5=CC=CC=C54)CCCN=C(N)N)CC6=CC=CC=C6)CC7=CN=CN7)CCC(=O)O
CHEMBL266417 mc3r_human Human No 8.6 EC50 = 2.8 Funct
Evaluated for agonist activity at cloned Melanocortin 3 receptorEvaluated for agonist activity at cloned Melanocortin 3 receptor
1074 17 13 11 1.3 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL3797808 mc3r_mouse Mouse No 7.7 EC50 = 20.2 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
2238 56 25 25 -2.0 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N5CCCC5C(=O)NCC(=O)N6CCCC6C(=O)NCC(=O)N7CCCC7C(=O)NCC(=O)N8CCCC8C(=O)NCC(=O)N9CCCC9C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)N
CHEMBL2323785 mc3r_mouse Mouse Yes 6.7 EC50 = 200 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1647 24 19 21 1.8 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC2CSCC(=O)N(CC(NC2=O)CCCNC(=N)N)C(C(=O)NC(C(=O)N1)CC(=O)N)CC3=CC4=CC=CC=C4C=C3)CC5=CC=CC=C5)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)CC9=CC=CC=C9
CHEMBL3421679 mc3r_human Human No 5.7 EC50 = 2000 Funct
Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter
708 15 7 6 1.6 CC(=O)NC1CC2=CC=CC=C2CN(C1=O)C(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL1209252 mc3r_human Human No 5.7 EC50 = 2000 Funct
Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation
561 8 0 6 5.0 CC(C)N(CC(C1CCCCC1)N2CCN(CC2)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C)C(=O)C
CHEMBL3421679 mc3r_human Human No 5.7 EC50 = 2000 Funct
Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter
708 15 7 6 1.6 CC(=O)NC1CC2=CC=CC=C2CN(C1=O)C(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL1209252 mc3r_human Human No 5.7 EC50 = 2000 Funct
Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation
561 8 0 6 5.0 CC(C)N(CC(C1CCCCC1)N2CCN(CC2)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C)C(=O)C
CHEMBL338594 mc3r_human Human No 5.7 EC50 = 2000 Funct
Agonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP releaseAgonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP release
596 8 3 7 3.4 CS(=O)(=O)NC1=CC=CC=C1N2CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4
CHEMBL202699 mc3r_human Human Yes 4.7 EC50 = 20000 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
737 18 8 7 3.0 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL212332 mc3r_human Human No 4.7 EC50 = 20000 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
550 13 6 6 1.9 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=C(C=C3)F)N
CHEMBL387246 mc3r_human Human Yes 4.7 EC50 = 20000 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
532 13 6 5 1.8 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=CC=C3)N
CHEMBL210009 mc3r_human Human No 4.7 EC50 = 20000 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
585 12 4 5 3.6 C1CCNC(C1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL202699 mc3r_human Human Yes 4.7 EC50 = 20000 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
737 18 8 7 3.0 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL213026 mc3r_human Human No 4.7 EC50 = 20000 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
679 15 5 6 4.1 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL213752 mc3r_human Human No 4.7 EC50 = 20000 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
585 12 4 5 3.6 C1CCNC(C1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL378571 mc3r_human Human No 4.7 EC50 = 20000 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
588 14 5 6 1.1 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)N)N)OCC3=CC4=CC=CC=C4C=C3
CHEMBL387246 mc3r_human Human Yes 4.7 EC50 = 20000 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
532 13 6 5 1.8 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=CC=C3)N
CHEMBL202699 mc3r_human Human Yes 4.7 EC50 = 20000 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
737 18 8 7 3.0 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL212332 mc3r_human Human No 4.7 EC50 = 20000 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
550 13 6 6 1.9 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=C(C=C3)F)N
CHEMBL387246 mc3r_human Human Yes 4.7 EC50 = 20000 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
532 13 6 5 1.8 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=CC=C3)N
CHEMBL210009 mc3r_human Human No 4.7 EC50 = 20000 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
585 12 4 5 3.6 C1CCNC(C1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL202699 mc3r_human Human Yes 4.7 EC50 = 20000 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
737 18 8 7 3.0 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL213026 mc3r_human Human No 4.7 EC50 = 20000 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
679 15 5 6 4.1 CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL213752 mc3r_human Human No 4.7 EC50 = 20000 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
585 12 4 5 3.6 C1CCNC(C1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL378571 mc3r_human Human No 4.7 EC50 = 20000 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
588 14 5 6 1.1 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)N)N)OCC3=CC4=CC=CC=C4C=C3
CHEMBL387246 mc3r_human Human Yes 4.7 EC50 = 20000 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
532 13 6 5 1.8 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=CC=C3)N
CHEMBL363061 mc3r_human Human No 6.7 EC50 = 203 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
866 22 8 8 3.8 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CCC(=O)C5=CC=C(C=C5)F
CHEMBL363061 mc3r_human Human No 6.7 EC50 = 203 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
866 22 8 8 3.8 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CCC(=O)C5=CC=C(C=C5)F
CHEMBL319871 mc3r_mouse Mouse No 5.7 EC50 = 2050 Funct
Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)
762 19 9 7 1.6 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL270923 mc3r_mouse Mouse No 4.7 EC50 = 20500 Funct
Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells
884 12 9 8 2.1 C1CN(C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2=CC=CC=C2C(=O)N1)CC3=CC=CC=C3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)CC(=O)N
CHEMBL569697 mc3r_mouse Mouse No 4.7 EC50 = 20500 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
604 16 8 7 0.3 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C=CC3=CC=C(C=C3)O
CHEMBL270923 mc3r_mouse Mouse No 4.7 EC50 = 20500 Funct
Agonist activity at mouse MC3R expressed in HEK293 cellsAgonist activity at mouse MC3R expressed in HEK293 cells
884 12 9 8 2.1 C1CN(C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2=CC=CC=C2C(=O)N1)CC3=CC=CC=C3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)CC(=O)N
CHEMBL569697 mc3r_mouse Mouse No 4.7 EC50 = 20500 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
604 16 8 7 0.3 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C=CC3=CC=C(C=C3)O
CHEMBL212976 mc3r_human Human No 5.7 EC50 = 2051 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
606 14 3 4 5.0 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)CCC3=CC=CC=C3)OCC4=CC5=CC=CC=C5C=C4
CHEMBL212976 mc3r_human Human No 5.7 EC50 = 2051 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
606 14 3 4 5.0 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)CCC3=CC=CC=C3)OCC4=CC5=CC=CC=C5C=C4
CHEMBL361253 mc3r_human Human No 6.7 EC50 = 207 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
834 22 8 6 4.4 C1=CC=C(C=C1)CCCC(=O)NC(CC2=CC=C(C=C2)Cl)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL361253 mc3r_human Human No 6.7 EC50 = 207 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
834 22 8 6 4.4 C1=CC=C(C=C1)CCCC(=O)NC(CC2=CC=C(C=C2)Cl)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL3287329 mc3r_mouse Mouse No 7.7 EC50 = 21 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
826 20 9 7 0.2 CC(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CC=C(C=C2)I)C(=O)N
CHEMBL3287329 mc3r_mouse Mouse No 7.7 EC50 = 21 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
826 20 9 7 0.2 CC(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CC=C(C=C2)I)C(=O)N
CHEMBL427629 mc3r_human Human No 6.7 EC50 = 210 Funct
Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.
1641 35 21 20 0.4 CCCCC(C(=O)NC1CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC1=O)CC2=CNC=N2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC6=CC=CC=C6)C(=O)NCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC7=CC=C(C=C7)O)N
CHEMBL379168 mc3r_human Human No 6.7 EC50 = 214 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
633 12 4 5 4.3 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C3CC4=CC=CC=C4CN3)OCC5=CC6=CC=CC=C6C=C5
CHEMBL379168 mc3r_human Human No 6.7 EC50 = 214 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
633 12 4 5 4.3 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C3CC4=CC=CC=C4CN3)OCC5=CC6=CC=CC=C6C=C5
CHEMBL449050 mc3r_human Human No 6.7 EC50 = 215 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
591 12 2 6 4.2 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)COC)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL449050 mc3r_human Human No 6.7 EC50 = 215 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
591 12 2 6 4.2 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)COC)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL346925 mc3r_mouse Mouse No 4.7 EC50 = 21900 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
697 18 8 7 1.1 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=CC4=CC=CC=C43)C(=O)N
CHEMBL3287325 mc3r_mouse Mouse No 7.7 EC50 = 22 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
918 20 9 7 0.2 CC(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)I)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CC=C(C=C2)I)C(=O)N
CHEMBL3287325 mc3r_mouse Mouse No 7.7 EC50 = 22 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
918 20 9 7 0.2 CC(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)I)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CC=C(C=C2)I)C(=O)N
CHEMBL3799955 mc3r_mouse Mouse No 7.6 EC50 = 22.7 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
1949 74 23 25 -0.8 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NC(CC5=CN=CN5)C(=O)NC(CC6=CC=CC=C6)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC7=CNC8=CC=CC=C87)C(=O)N
CHEMBL3799955 mc3r_mouse Mouse No 7.6 EC50 = 22.7 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
1949 74 23 25 -0.8 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NC(CC5=CN=CN5)C(=O)NC(CC6=CC=CC=C6)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC7=CNC8=CC=CC=C87)C(=O)N
CHEMBL370261 mc3r_mouse Mouse No 6.7 EC50 = 220 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
854 30 9 7 6.2 CCCCCCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL370261 mc3r_mouse Mouse No 6.7 EC50 = 220 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
854 30 9 7 6.2 CCCCCCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL275067 mc3r_human Human No 5.7 EC50 = 2200 Funct
In vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells
588 13 3 6 3.0 CCCC(=O)C1(CCN(CC1)C(=O)C(CC2=CC=C(C=C2)OC)NC(=O)C(CC3=CN=CN3)NC(=O)C)C4=CC=CC=C4
CHEMBL2323529 mc3r_mouse Mouse Yes 5.7 EC50 = 2230 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1521 22 21 33 3.9 CC1C(=NC(C(=NC(CSSCC(C(=NC(C(=NC(C(=NC2CSCC(=O)N(CC(N=C2O)CCCNC(=N)N)C(C(=NC(C(=N1)O)CC(=N)O)O)C)O)CC3=CC=CC=C3)O)CC4=CN=CN4)O)N=C(C(CC5=CC=C(C=C5)O)N)O)C(=NC(CC6=CC=C(C=C6)O)C(=N)O)O)O)CC7=CC=CC=C7)O
CHEMBL2369131 mc3r_mouse Mouse No 4.7 EC50 = 22600 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay
2327 55 32 33 -6.4 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCNC(=N)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CC(=O)O)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)CC7=CC=CC=C7
CHEMBL2369131 mc3r_mouse Mouse No 4.7 EC50 = 22600 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay
2327 55 32 33 -6.4 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCNC(=N)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CC(=O)O)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)CC7=CC=CC=C7
CHEMBL317968 mc3r_mouse Mouse No 5.6 EC50 = 2270 Funct
In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.
697 18 8 7 0.5 CC(=O)NC(CC1=CC=NC=C1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL272099 mc3r_human Human No 6.6 EC50 = 230 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cellsAgonist activity at human MC3 receptor expressed in HEK293 cells
430 6 1 4 4.5 C1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)N)CN4C=NC=N4
CHEMBL249321 mc3r_human Human No 6.6 EC50 = 230 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
572 8 3 6 4.2 CC1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)F)NC(=O)C4CN(CCN4)C)C(=O)NC(C)(C)C
CHEMBL272099 mc3r_human Human No 6.6 EC50 = 230 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cellsAgonist activity at human MC3 receptor expressed in HEK293 cells
430 6 1 4 4.5 C1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)N)CN4C=NC=N4
CHEMBL2323787 mc3r_mouse Mouse Yes 6.6 EC50 = 230 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1673 25 21 33 7.1 CC1C(=NC(C(=NC(CSSCC(C(=NC(C(=NC(C(=NC2CSCC(=O)N(CC(N=C2O)CCCNC(=N)N)C(C(=NC(C(=N1)O)CC(=N)O)O)CC3=CC=C(C=C3)C4=CC=CC=C4)O)CC5=CC=CC=C5)O)CC6=CN=CN6)O)N=C(C(CC7=CC=C(C=C7)O)N)O)C(=NC(CC8=CC=C(C=C8)O)C(=N)O)O)O)CC9=CC=CC=C9)O
CHEMBL249321 mc3r_human Human No 6.6 EC50 = 230 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
572 8 3 6 4.2 CC1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)F)NC(=O)C4CN(CCN4)C)C(=O)NC(C)(C)C
CHEMBL327450 mc3r_human Human No 6.6 EC50 = 230 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
732 20 9 8 0.7 CSCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL214347 mc3r_human Human No 6.6 EC50 = 232 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
633 12 4 5 4.3 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C3CC4=CC=CC=C4CN3)OCC5=CC6=CC=CC=C6C=C5
CHEMBL214347 mc3r_human Human No 6.6 EC50 = 232 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
633 12 4 5 4.3 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C3CC4=CC=CC=C4CN3)OCC5=CC6=CC=CC=C6C=C5
CHEMBL2096693 mc3r_mouse Mouse No 4.6 EC50 = 23200 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
659 15 7 7 -0.4 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)N3CC4=CC=CC=C4CC3C(=O)N
CHEMBL270691 mc3r_mouse Mouse No 4.6 EC50 = 23300 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay
441 4 1 2 5.7 C1=CC=C(C=C1)CC2C(=O)N(C3=C(C=CC(=C3)Cl)C(=O)N2)CC4=CC5=CC=CC=C5C=C4
CHEMBL270691 mc3r_mouse Mouse No 4.6 EC50 = 23300 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay
441 4 1 2 5.7 C1=CC=C(C=C1)CC2C(=O)N(C3=C(C=CC(=C3)Cl)C(=O)N2)CC4=CC5=CC=CC=C5C=C4
CHEMBL183476 mc3r_human Human No 5.6 EC50 = 2364 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
744 19 8 6 2.6 CCC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL183476 mc3r_human Human No 5.6 EC50 = 2364 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
744 19 8 6 2.6 CCC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL460349 mc3r_human Human No 6.6 EC50 = 237 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
505 8 2 5 3.7 CCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL460349 mc3r_human Human No 6.6 EC50 = 237 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
505 8 2 5 3.7 CCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL3600918 mc3r_human Human No 5.6 EC50 = 2370 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1116 17 10 11 1.8 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(NC(=O)C(N(C(=O)C(NC(=O)C(N(C1=O)C)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL3600918 mc3r_human Human No 5.6 EC50 = 2370 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1116 17 10 11 1.8 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(NC(=O)C(N(C(=O)C(NC(=O)C(N(C1=O)C)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL2369969 mc3r_mouse Mouse No 4.6 EC50 = 23800 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1402 19 17 18 -1.6 CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)CC3=CNC=N3)NC(=O)C(CC4=CC=C(C=C4)O)N)C(CC5=CC=C(C=C5)O)C(=O)N)(C)C(=O)O)CC6=CC=CC=C6)C)CC(=O)N)CC7=CNC8=CC=CC=C87
CHEMBL2369969 mc3r_mouse Mouse No 4.6 EC50 = 23800 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1402 19 17 18 -1.6 CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC=CC=C2)CC3=CNC=N3)NC(=O)C(CC4=CC=C(C=C4)O)N)C(CC5=CC=C(C=C5)O)C(=O)N)(C)C(=O)O)CC6=CC=CC=C6)C)CC(=O)N)CC7=CNC8=CC=CC=C87
CHEMBL448536 mc3r_mouse Mouse No 6.6 EC50 = 240 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
711 18 9 8 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)C#N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL448536 mc3r_mouse Mouse No 6.6 EC50 = 240 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
711 18 9 8 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)C#N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL409636 mc3r_human Human No 6.6 EC50 = 240 Funct
Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.
1605 35 21 18 0.7 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CNC=N2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC6=CC=CC=C6)C(=O)NCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC7=CC=C(C=C7)O)N
CHEMBL365005 mc3r_human Human No 5.6 EC50 = 2400 Funct
Effective concentration against human melanocortin 3 receptor in cAMP release assayEffective concentration against human melanocortin 3 receptor in cAMP release assay
607 10 2 7 5.7 CC(CCC1=CC(=NN(C1=O)C2=CC=C(C=C2)OC)SC3=CC=C(C=C3)Cl)NC(=O)C4CNCC4C5=CC=C(C=C5)F
CHEMBL365005 mc3r_human Human No 5.6 EC50 = 2400 Funct
Effective concentration against human melanocortin 3 receptor in cAMP release assayEffective concentration against human melanocortin 3 receptor in cAMP release assay
607 10 2 7 5.7 CC(CCC1=CC(=NN(C1=O)C2=CC=C(C=C2)OC)SC3=CC=C(C=C3)Cl)NC(=O)C4CNCC4C5=CC=C(C=C5)F
CHEMBL2370963 mc3r_human Human Yes 5.6 EC50 = 2400 Funct
Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.
1563 49 22 19 -0.3 CCCCC(C(=O)NCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC6=CC=C(C=C6)O)N
CHEMBL249322 mc3r_human Human No 6.6 EC50 = 241 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
586 8 3 6 4.6 CC1(CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)F)NC(=O)C4CN(CCN4)C)C(=O)NC(C)(C)C)C
CHEMBL249322 mc3r_human Human No 6.6 EC50 = 241 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
586 8 3 6 4.6 CC1(CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)F)NC(=O)C4CN(CCN4)C)C(=O)NC(C)(C)C)C
CHEMBL565688 mc3r_mouse Mouse No 4.6 EC50 = 24100 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
602 17 7 6 0.8 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)CC=CC3=CC=CC=C3
CHEMBL565688 mc3r_mouse Mouse No 4.6 EC50 = 24100 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
602 17 7 6 0.8 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)CC=CC3=CC=CC=C3
CHEMBL3421678 mc3r_human Human No 5.6 EC50 = 2435 Funct
Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter
826 15 8 6 2.4 CC(=O)NC1CC2=C(CN(C1=O)C(CC3=CC=C(C=C3)Br)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N)NC6=CC=CC=C26
CHEMBL3421678 mc3r_human Human No 5.6 EC50 = 2435 Funct
Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter
826 15 8 6 2.4 CC(=O)NC1CC2=C(CN(C1=O)C(CC3=CC=C(C=C3)Br)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N)NC6=CC=CC=C26
CHEMBL433296 mc3r_mouse Mouse No 5.6 EC50 = 2440 Funct
Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL377778 mc3r_human Human No 5.6 EC50 = 2474 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
614 12 5 6 1.7 C1CNCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3C(=O)NCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL377778 mc3r_human Human No 5.6 EC50 = 2474 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
614 12 5 6 1.7 C1CNCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3C(=O)NCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL50056 mc3r_human Human Yes 6.6 EC50 = 248 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL50056 mc3r_human Human Yes 6.6 EC50 = 248 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL339053 mc3r_human Human Yes 5.6 EC50 = 2487 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
589 8 2 5 5.9 C1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)CN6C=NC=N6
CHEMBL339053 mc3r_human Human Yes 5.6 EC50 = 2487 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
589 8 2 5 5.9 C1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)CN6C=NC=N6
CHEMBL339053 mc3r_human Human Yes 5.6 EC50 = 2487 Funct
Evaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulation
589 8 2 5 5.9 C1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)CN6C=NC=N6
CHEMBL339053 mc3r_human Human Yes 5.6 EC50 = 2487 Funct
Functional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC3R) receptorFunctional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC3R) receptor
589 8 2 5 5.9 C1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)CN6C=NC=N6
CHEMBL254589 mc3r_human Human No 6.6 EC50 = 249.9 Funct
Agonist activity at human MC3R expressed in CHO cells assessed as cAMP releaseAgonist activity at human MC3R expressed in CHO cells assessed as cAMP release
577 7 1 4 5.9 CCC(C1=C(C=CC(=C1)Cl)C2CCN(CC2)C(=O)C3CN(CC3C4=C(C=C(C=C4)Cl)F)C(C)(C)C)NC(=O)C
CHEMBL254589 mc3r_human Human No 6.6 EC50 = 249.9 Funct
Agonist activity at human MC3R expressed in CHO cells assessed as cAMP releaseAgonist activity at human MC3R expressed in CHO cells assessed as cAMP release
577 7 1 4 5.9 CCC(C1=C(C=CC(=C1)Cl)C2CCN(CC2)C(=O)C3CN(CC3C4=C(C=C(C=C4)Cl)F)C(C)(C)C)NC(=O)C
CHEMBL506272 mc3r_human Human No 7.6 EC50 = 25 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
630 11 3 6 3.8 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3CCC(=O)N3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL506272 mc3r_human Human No 7.6 EC50 = 25 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
630 11 3 6 3.8 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3CCC(=O)N3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL373344 mc3r_human Human No 7.6 EC50 = 25.1 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 11 10 -0.8 CCCCN(CC(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC(=O)N)C(=O)C
CHEMBL373344 mc3r_human Human No 7.6 EC50 = 25.1 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 11 10 -0.8 CCCCN(CC(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC(=O)N)C(=O)C
CHEMBL370254 mc3r_mouse Mouse Yes 6.6 EC50 = 250 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
644 17 9 7 -1.1 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)N
CHEMBL410795 mc3r_human Human Yes 6.6 EC50 = 250 Funct
Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorEffective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptor
1571 49 23 32 4.2 CC(C)C(C(=NC(CCSC)C(=NCC(=NC(CC1=CN=CN1)C(=NC(CC2=CC=CC=C2)C(=NC(CCCNC(=N)N)C(=NC(CC3=CNC4=CC=CC=C43)C(=NC(CC(=O)O)C(=NC(CCCNC(=N)N)C(=NC(CC5=CC=CC=C5)C(=NCC(=O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(CC6=CC=C(C=C6)O)N)O
CHEMBL370254 mc3r_mouse Mouse Yes 6.6 EC50 = 250 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
644 17 9 7 -1.1 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)N
CHEMBL13910 mc3r_human Human No 6.6 EC50 = 250 Funct
In vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin 3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells
650 14 3 6 4.7 CCCC(=O)C1(CCN(CC1)C(=O)C(CC2=CC=C(C=C2)OC)NC(=O)C(CC3=CN=CN3)NC(=O)C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1209382 mc3r_human Human No 5.6 EC50 = 2500 Funct
Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation
571 10 0 8 4.1 CC(C)CC(CN(C(C)C)S(=O)(=O)C)N1CCN(CC1)C(=O)C2CN(CC2C3=C(C=C(C=C3)F)F)C(C)(C)C
CHEMBL524861 mc3r_human Human No 5.6 EC50 = 2500 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
1041 16 13 11 -1.3 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2CC(CN2C1=O)N=C(N)N)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
CHEMBL1209382 mc3r_human Human No 5.6 EC50 = 2500 Funct
Agonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulationAgonist activity at human MC3 receptor expressed in CHO cells assessed as increase of alpha-MSH-induced cAMP accumulation
571 10 0 8 4.1 CC(C)CC(CN(C(C)C)S(=O)(=O)C)N1CCN(CC1)C(=O)C2CN(CC2C3=C(C=C(C=C3)F)F)C(C)(C)C
CHEMBL524861 mc3r_human Human No 5.6 EC50 = 2500 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
1041 16 13 11 -1.3 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2CC(CN2C1=O)N=C(N)N)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
CHEMBL2323798 mc3r_mouse Mouse Yes 5.6 EC50 = 2540 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1608 23 20 33 6.2 CC1C(=NC(C(=NC(CSSCC(C(=NC(C(=NC(C(=NC2CSCC(=O)N(CC(N=C2O)CCCCN)C(C(=NC(C(=N1)O)CC(=N)O)O)CC3=CNC4=CC=CC=C43)O)CC5=CC=CC=C5)O)CC6=CN=CN6)O)N=C(C(CC7=CC=C(C=C7)O)N)O)C(=NC(CC8=CC=C(C=C8)O)C(=N)O)O)O)CC9=CC=CC=C9)O
CHEMBL569222 mc3r_mouse Mouse No 4.6 EC50 = 25900 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
662 19 7 8 1.1 C1OC2=C(O1)C=C(C=C2)CCCCC(=O)NC(CC3=CN=CN3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL569222 mc3r_mouse Mouse No 4.6 EC50 = 25900 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
662 19 7 8 1.1 C1OC2=C(O1)C=C(C=C2)CCCCC(=O)NC(CC3=CN=CN3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL569693 mc3r_mouse Mouse No 7.6 EC50 = 26 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
789 22 8 7 1.6 C1C=NC=C1CC(C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N)NC(=O)CCCC5=CC=CC=C5
CHEMBL569693 mc3r_mouse Mouse No 7.6 EC50 = 26 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
789 22 8 7 1.6 C1C=NC=C1CC(C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N)NC(=O)CCCC5=CC=CC=C5
CHEMBL213956 mc3r_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
585 12 4 5 3.6 C1CCNC(C1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL213956 mc3r_human Human No 6.6 EC50 = 260 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
585 12 4 5 3.6 C1CCNC(C1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL400456 mc3r_human Human No 6.6 EC50 = 263 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
578 9 2 6 5.0 CCC(C)C1(CCN(CC1)C(=O)C(CC2=CC=C(C=C2)Cl)NC(=O)C3CC4=CC=CC=C4CN3)CC5=NN=NN5C
CHEMBL400456 mc3r_human Human No 6.6 EC50 = 263 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
578 9 2 6 5.0 CCC(C)C1(CCN(CC1)C(=O)C(CC2=CC=C(C=C2)Cl)NC(=O)C3CC4=CC=CC=C4CN3)CC5=NN=NN5C
CHEMBL434357 mc3r_human Human No 5.6 EC50 = 2635 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
796 21 8 9 2.1 COP(=O)(NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N)OC
CHEMBL434357 mc3r_human Human No 5.6 EC50 = 2635 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
796 21 8 9 2.1 COP(=O)(NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N)OC
CHEMBL209587 mc3r_human Human No 6.6 EC50 = 266 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
640 14 6 7 0.9 C1C(CN(C1C(=O)NCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC3=CN=CN3)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL191304 mc3r_mouse Mouse No 6.6 EC50 = 266 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
896 33 9 7 7.9 CCCCCCCCCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL209587 mc3r_human Human No 6.6 EC50 = 266 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
640 14 6 7 0.9 C1C(CN(C1C(=O)NCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC3=CN=CN3)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL191304 mc3r_mouse Mouse No 6.6 EC50 = 266 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
896 33 9 7 7.9 CCCCCCCCCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL427205 mc3r_human Human Yes 7.6 EC50 = 27 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
830 13 10 8 1.8 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)C(C)C
CHEMBL438744 mc3r_human Human Yes 7.6 EC50 = 27 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation
767 9 9 9 0.2 C1CCNC(=O)C2=NC=CN=C2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1)C(=O)N)CC3=CNC4=CC=CC=C43)CCCN=C(N)N)CC5=CC=CC=C5
CHEMBL427205 mc3r_human Human Yes 7.6 EC50 = 27 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
830 13 10 8 1.8 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)C(C)C
CHEMBL438744 mc3r_human Human Yes 7.6 EC50 = 27 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation
767 9 9 9 0.2 C1CCNC(=O)C2=NC=CN=C2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1)C(=O)N)CC3=CNC4=CC=CC=C43)CCCN=C(N)N)CC5=CC=CC=C5
CHEMBL3799094 mc3r_mouse Mouse No 7.6 EC50 = 27.2 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
1569 37 17 19 -3.2 C1CC(NC1)C(=O)NCC(=O)N2CCCC2C(=O)NCC(=O)N3CCCC3C(=O)NCC(=O)N4CCCC4C(=O)NCC(=O)N5CCCC5C(=O)NCC(=O)N6CCCC6C(=O)NCC(=O)NC(CC7=CN=CN7)C(=O)NC(CC8=CC=CC=C8)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC9=CNC1=CC=CC=C19)C(=O)N
CHEMBL3799094 mc3r_mouse Mouse No 7.6 EC50 = 27.2 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
1569 37 17 19 -3.2 C1CC(NC1)C(=O)NCC(=O)N2CCCC2C(=O)NCC(=O)N3CCCC3C(=O)NCC(=O)N4CCCC4C(=O)NCC(=O)N5CCCC5C(=O)NCC(=O)N6CCCC6C(=O)NCC(=O)NC(CC7=CN=CN7)C(=O)NC(CC8=CC=CC=C8)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC9=CNC1=CC=CC=C19)C(=O)N
CHEMBL2115441 mc3r_human Human No 7.6 EC50 = 27.6 Funct
Effective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptorEffective concentration that was able to generate 50% maximal intracellular cAMP in L-cells transfected with Melanocortin 3 receptor
1095 17 14 12 -0.2 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C)C(=O)N)NC(=O)C
CHEMBL152986 mc3r_mouse Mouse No 4.6 EC50 = 27000 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
647 18 8 7 -0.1 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=CC=C3)C(=O)N
CHEMBL460142 mc3r_human Human No 6.6 EC50 = 271 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
519 8 2 5 4.2 CC(C)C1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL460142 mc3r_human Human No 6.6 EC50 = 271 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
519 8 2 5 4.2 CC(C)C1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL364726 mc3r_mouse Mouse No 6.6 EC50 = 277 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
896 35 9 7 9.1 CCCCCCCCCCCCCCCCCCNC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL364726 mc3r_mouse Mouse No 6.6 EC50 = 277 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
896 35 9 7 9.1 CCCCCCCCCCCCCCCCCCNC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL89004 mc3r_human Human No 7.6 EC50 = 28 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
762 20 9 7 1.6 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)NC(=O)CC5=CC=CC=C5
CHEMBL383250 mc3r_human Human Yes 5.6 EC50 = 2800 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
910 15 11 10 1.6 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC5=CC=CC=C5C=C4)CCC(=O)O
CHEMBL383250 mc3r_human Human Yes 5.6 EC50 = 2800 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
910 15 11 10 1.6 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC5=CC=CC=C5C=C4)CCC(=O)O
CHEMBL566150 mc3r_mouse Mouse No 4.6 EC50 = 28050 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
606 16 7 7 0.7 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C=CC3=CC=CC=C3F
CHEMBL566150 mc3r_mouse Mouse No 4.6 EC50 = 28050 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
606 16 7 7 0.7 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C=CC3=CC=CC=C3F
CHEMBL210011 mc3r_human Human No 6.5 EC50 = 286 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
585 12 4 5 3.6 C1CCNC(C1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL210011 mc3r_human Human No 6.5 EC50 = 286 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
585 12 4 5 3.6 C1CCNC(C1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL398664 mc3r_human Human Yes 7.5 EC50 = 29 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation
800 9 9 8 0.6 C1CCNCCCC(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1)C(=O)N)CC3=CNC4=CC=CC=C43)CCCN=C(N)N)CC5=CC=CC=C5
CHEMBL2369967 mc3r_mouse Mouse No 7.5 EC50 = 29 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1421 21 18 18 -2.5 CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)N1)NC(=O)C(CC2=CC=C(C=C2)O)N)C(CC3=CC=C(C=C3)O)C(=O)N)(C)C(=O)O)CC4=CC=CC=C4)C)CC(=O)N)CC5=CNC6=CC=CC=C65)CCCN=C(N)N)CC7=CC=CC=C7
CHEMBL398664 mc3r_human Human Yes 7.5 EC50 = 29 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation
800 9 9 8 0.6 C1CCNCCCC(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1)C(=O)N)CC3=CNC4=CC=CC=C43)CCCN=C(N)N)CC5=CC=CC=C5
CHEMBL2369967 mc3r_mouse Mouse No 7.5 EC50 = 29 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1421 21 18 18 -2.5 CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)N1)NC(=O)C(CC2=CC=C(C=C2)O)N)C(CC3=CC=C(C=C3)O)C(=O)N)(C)C(=O)O)CC4=CC=CC=C4)C)CC(=O)N)CC5=CNC6=CC=CC=C65)CCCN=C(N)N)CC7=CC=CC=C7
CHEMBL269274 mc3r_mouse Mouse No 7.5 EC50 = 29.8 Funct
Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor
4418 53 53 70 -7.4 CC1C(=O)NC(C(=O)NC2CSSSSCC3C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)N4CCCC4C(=O)NC(CSSSSCC(NC(=O)C(NC(=O)C5CSSSSCC(C(=O)NC(C(=O)NN(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N5)CC6=CC=CC=C6)C)CC(=O)N)CC7=CNC8=CC=CC=C87)CCCN=C(N)N)CC9=CC=CC=C9)CC4=CNC=N4)NC(=O)C(NC2=O)CC2=CC=C(C=C2)O)CC2=CC=C(C=C2)O)C(=O)NC(CCCN=C(N)N)C(=O)C(=O)N)C(=O)NC(CSSSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3)CO)CCC(=O)O)CC2=CNC=N2)CC(C)C)CCCN=C(N)N)C(C)C)NNC(=O)C)C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C)CC(=O)O)C(C)C)CCC(=O)N)CCC(=O)N)CC(C)C)C(C)O
CHEMBL399715 mc3r_human Human No 5.5 EC50 = 2950 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
606 8 2 7 3.7 CN1C(=NN=N1)CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6CCOCC6
CHEMBL399715 mc3r_human Human No 5.5 EC50 = 2950 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
606 8 2 7 3.7 CN1C(=NN=N1)CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6CCOCC6
CHEMBL330561 mc3r_mouse Mouse No 5.5 EC50 = 2950 Funct
In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.
702 18 8 7 1.2 CC(=O)NC(CC1=CC=CS1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL377210 mc3r_human Human No 5.5 EC50 = 2986 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
588 14 5 6 1.1 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)N)N)OCC3=CC4=CC=CC=C4C=C3
CHEMBL377210 mc3r_human Human No 5.5 EC50 = 2986 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
588 14 5 6 1.1 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)N)N)OCC3=CC4=CC=CC=C4C=C3
CHEMBL3422426 mc3r_mouse Mouse Yes 8.5 EC50 = 3 Funct
Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay
1074 17 13 11 1.3 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL266665 mc3r_human Human No 8.5 EC50 = 3 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
965 27 10 9 2.9 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CN=CN5)NC(=O)CCCC(=O)C6=CC=CC=C6
CHEMBL3422426 mc3r_mouse Mouse Yes 8.5 EC50 = 3 Funct
Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay
1074 17 13 11 1.3 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL266665 mc3r_human Human No 8.5 EC50 = 3 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
965 27 10 9 2.9 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CN=CN5)NC(=O)CCCC(=O)C6=CC=CC=C6
CHEMBL410404 mc3r_rat Rat No 8.5 EC50 = 3 Funct
Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)
1096 18 14 14 -0.6 CC(C(C(=O)N)NC(=O)C1CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5)NC(=O)C(CC6=CC=CC=C6)N)O
CHEMBL3358543 mc3r_mouse Mouse No 8.5 EC50 = 3.1 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CC2=CN(CCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358543 mc3r_mouse Mouse No 8.5 EC50 = 3.1 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CC2=CN(CCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358534 mc3r_mouse Mouse No 8.5 EC50 = 3.3 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1052 34 12 12 3.3 CCCCC(C(=O)NC(CCCC)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CCCN=[N+]=[N-])C(=O)N)NC(=O)C
CHEMBL3358534 mc3r_mouse Mouse No 8.5 EC50 = 3.3 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1052 34 12 12 3.3 CCCCC(C(=O)NC(CCCC)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CCCN=[N+]=[N-])C(=O)N)NC(=O)C
CHEMBL3358538 mc3r_mouse Mouse No 8.4 EC50 = 3.7 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1052 34 12 12 3.3 CCCCC(C(=O)N)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CN=CN4)NC(=O)C(CCCN=[N+]=[N-])NC(=O)C(CCCC)NC(=O)C
CHEMBL3358538 mc3r_mouse Mouse No 8.4 EC50 = 3.7 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1052 34 12 12 3.3 CCCCC(C(=O)N)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CN=CN4)NC(=O)C(CCCN=[N+]=[N-])NC(=O)C(CCCC)NC(=O)C
CHEMBL3358547 mc3r_mouse Mouse No 8.4 EC50 = 3.7 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CCCCN2C=C(CC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3358547 mc3r_mouse Mouse No 8.4 EC50 = 3.7 Funct
Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayActivity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assay
1048 17 12 12 0.5 CCCCC(C(=O)NC1CCCCN2C=C(CC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65)C(=O)N)N=N2)NC(=O)C
CHEMBL3799563 mc3r_mouse Mouse No 7.5 EC50 = 30.9 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
962 35 11 13 -1.4 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)NC(=O)COCC(=O)NCCCOCCOCCOCCCN
CHEMBL3799563 mc3r_mouse Mouse No 7.5 EC50 = 30.9 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
962 35 11 13 -1.4 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)NC(=O)COCC(=O)NCCCOCCOCCOCCCN
CHEMBL380638 mc3r_human Human Yes 6.5 EC50 = 300 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
844 15 10 8 2.3 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CCCC
CHEMBL517108 mc3r_human Human No 6.5 EC50 = 300 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
491 7 2 5 3.2 CC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL380638 mc3r_human Human Yes 6.5 EC50 = 300 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
844 15 10 8 2.3 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CCCC
CHEMBL517108 mc3r_human Human No 6.5 EC50 = 300 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
491 7 2 5 3.2 CC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL413439 mc3r_human Human No 6.5 EC50 = 300 Funct
Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)
1603 47 21 20 -0.3 CCCCC(C(=O)NCC(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC3=CC=CC=C3C=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)NC(CC(=O)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC6=CC=CC=C6)C(=O)NCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CC7=CC=C(C=C7)O)N
CHEMBL316038 mc3r_human Human No 6.5 EC50 = 300 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
702 19 10 8 -0.7 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)NC(=O)CO
CHEMBL349795 mc3r_mouse Mouse No 4.5 EC50 = 30250 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
653 18 8 8 -0.4 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=CS3)C(=O)N
CHEMBL569696 mc3r_mouse Mouse No 4.5 EC50 = 30300 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
656 16 7 9 1.5 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C=CC3=CC(=CC=C3)C(F)(F)F
CHEMBL569696 mc3r_mouse Mouse No 4.5 EC50 = 30300 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
656 16 7 9 1.5 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C=CC3=CC(=CC=C3)C(F)(F)F
CHEMBL186687 mc3r_human Human No 5.5 EC50 = 3044 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
755 19 8 7 2.0 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CC#N
CHEMBL186687 mc3r_human Human No 5.5 EC50 = 3044 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
755 19 8 7 2.0 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CC#N
CHEMBL1204061 mc3r_human Human No 5.5 EC50 = 3050 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
489 4 1 6 4.6 CC1CN(CC(C1(C2=CC=C(C=C2)F)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C
CHEMBL1204061 mc3r_human Human No 5.5 EC50 = 3050 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
489 4 1 6 4.6 CC1CN(CC(C1(C2=CC=C(C=C2)F)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C
CHEMBL272439 mc3r_mouse Mouse No 4.5 EC50 = 30650 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay
400 6 3 3 1.7 C1=CC=C(C=C1)CN2C3=C(C=CC(=C3)Cl)C(=O)NC(C2=O)CCCN=C(N)N
CHEMBL272439 mc3r_mouse Mouse No 4.5 EC50 = 30650 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay
400 6 3 3 1.7 C1=CC=C(C=C1)CN2C3=C(C=CC(=C3)Cl)C(=O)NC(C2=O)CCCN=C(N)N
CHEMBL2369977 mc3r_mouse Mouse No 4.5 EC50 = 30800 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1459 23 18 19 -1.8 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCCN)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL2369977 mc3r_mouse Mouse No 4.5 EC50 = 30800 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1459 23 18 19 -1.8 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCCN)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL185869 mc3r_human Human No 5.5 EC50 = 3083 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
760 20 8 7 2.9 CCOC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL185869 mc3r_human Human No 5.5 EC50 = 3083 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
760 20 8 7 2.9 CCOC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL2369485 mc3r_mouse Mouse No 6.5 EC50 = 309 Funct
Effective concentration against mouse Melanocortin 3 receptorEffective concentration against mouse Melanocortin 3 receptor
1529 24 22 22 -3.2 CC1C(=O)NC(C(=O)NC(NC(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NNC6CC7=C(C=C(C=C7)O)NC6=O)C(=O)NNC(CC8=CC=C(C=C8)O)C(=O)C(=O)O)CC9=CC=CC=C9
CHEMBL411378 mc3r_rat Rat No 7.5 EC50 = 31 Funct
Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)
1110 18 14 14 -0.2 CC1=NC=C(N1)CC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N2)NC(=O)C(CC3=CC=CC=C3)N)C(=O)NC(C(C)O)C(=O)N)CC4=CNC5=CC=CC=C54)CCCN=C(N)N)CC6=CC=CC=C6
CHEMBL378446 mc3r_human Human No 6.5 EC50 = 313 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
663 15 4 5 4.4 CC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL360598 mc3r_human Human No 6.5 EC50 = 313 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
793 19 8 7 3.0 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C5=CN=CC=C5
CHEMBL378446 mc3r_human Human No 6.5 EC50 = 313 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
663 15 4 5 4.4 CC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL360598 mc3r_human Human No 6.5 EC50 = 313 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
793 19 8 7 3.0 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C5=CN=CC=C5
CHEMBL210008 mc3r_human Human No 5.5 EC50 = 3152 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
633 12 4 5 4.3 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C3CC4=CC=CC=C4CN3)OCC5=CC6=CC=CC=C6C=C5
CHEMBL210008 mc3r_human Human No 5.5 EC50 = 3152 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
633 12 4 5 4.3 C1C(CN(C1CCCN=C(N)N)C(=O)C(CC2=CC=CC=C2)NC(=O)C3CC4=CC=CC=C4CN3)OCC5=CC6=CC=CC=C6C=C5
CHEMBL191120 mc3r_human Human No 6.5 EC50 = 316.2 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 11 10 -0.5 CCCCC(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C(=O)N(CC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL191120 mc3r_human Human No 6.5 EC50 = 316.2 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 11 10 -0.5 CCCCC(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C(=O)N(CC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL365262 mc3r_human Human No 5.5 EC50 = 3162.3 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
918 30 10 10 -0.4 CCCCN(CC(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C(=O)N(CCC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)C(=O)C
CHEMBL365262 mc3r_human Human No 5.5 EC50 = 3162.3 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
918 30 10 10 -0.4 CCCCN(CC(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C(=O)N(CCC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)C(=O)C
CHEMBL270270 mc3r_mouse Mouse No 6.5 EC50 = 320 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay
372 6 2 3 2.7 C1=CC=C(C=C1)CN2C3=C(C=CC(=C3)Cl)C(=O)NC(C2=O)CCCCN
CHEMBL2369982 mc3r_mouse Mouse No 6.5 EC50 = 320 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1537 23 19 19 -1.5 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC5=CC=CC=C54)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(CC8=CC=C(C=C8)O)C(=O)N)(C)C(=O)O)CC9=CC=CC=C9
CHEMBL270270 mc3r_mouse Mouse No 6.5 EC50 = 320 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay
372 6 2 3 2.7 C1=CC=C(C=C1)CN2C3=C(C=CC(=C3)Cl)C(=O)NC(C2=O)CCCCN
CHEMBL2369982 mc3r_mouse Mouse No 6.5 EC50 = 320 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1537 23 19 19 -1.5 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC5=CC=CC=C54)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(CC8=CC=C(C=C8)O)C(=O)N)(C)C(=O)O)CC9=CC=CC=C9
CHEMBL1688106 mc3r_mouse Mouse Yes 5.5 EC50 = 3200 Funct
Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay
1636 24 20 21 0.6 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC2CSCC(=O)N(CC(NC2=O)CC3=CC=CC=C3)C(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC4=CNC5=CC=CC=C54)CCCNC(=N)N)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)CC9=CC=CC=C9
CHEMBL1688106 mc3r_mouse Mouse Yes 5.5 EC50 = 3200 Funct
Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay
1636 24 20 21 0.6 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC2CSCC(=O)N(CC(NC2=O)CC3=CC=CC=C3)C(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC4=CNC5=CC=CC=C54)CCCNC(=N)N)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)CC9=CC=CC=C9
CHEMBL1688111 mc3r_mouse Mouse Yes 6.5 EC50 = 324 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1636 24 22 33 5.6 CC1C(=NC(C(=NC(CSSCC(C(=NC(C(=NC(C(=NC2CSCC(=O)N(CC(N=C2O)CCCNC(=N)N)C(C(=NC(C(=N1)O)CC(=N)O)O)CC3=CNC4=CC=CC=C43)O)CC5=CC=CC=C5)O)CC6=CN=CN6)O)N=C(C(CC7=CC=C(C=C7)O)N)O)C(=NC(CC8=CC=C(C=C8)O)C(=N)O)O)O)CC9=CC=CC=C9)O
CHEMBL3601428 mc3r_human Human No 6.5 EC50 = 326 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1130 17 9 11 2.0 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(N(C(=O)C(N(C(=O)C(NC(=O)C(N(C1=O)C)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL3601428 mc3r_human Human No 6.5 EC50 = 326 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1130 17 9 11 2.0 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(N(C(=O)C(N(C(=O)C(NC(=O)C(N(C1=O)C)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL2369975 mc3r_mouse Mouse No 7.5 EC50 = 33 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1563 24 19 19 -1.1 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=C(C=C4)C5=CC=CC=C5)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(CC8=CC=C(C=C8)O)C(=O)N)(C)C(=O)O)CC9=CC=CC=C9
CHEMBL2369975 mc3r_mouse Mouse No 7.5 EC50 = 33 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1563 24 19 19 -1.1 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=C(C=C4)C5=CC=CC=C5)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(CC8=CC=C(C=C8)O)C(=O)N)(C)C(=O)O)CC9=CC=CC=C9
CHEMBL505536 mc3r_human Human No 6.5 EC50 = 330 Funct
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation
905 11 9 11 2.3 C1C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2=C(S1)C=CC(=C2)[N+](=O)[O-])CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CC6=CC=CC=C6C=C5)C(=O)N
CHEMBL505536 mc3r_human Human No 6.5 EC50 = 330 Funct
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation
905 11 9 11 2.3 C1C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2=C(S1)C=CC(=C2)[N+](=O)[O-])CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CC6=CC=CC=C6C=C5)C(=O)N
CHEMBL566162 mc3r_mouse Mouse No 4.5 EC50 = 33800 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
622 16 7 6 1.2 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C=CC3=CC(=CC=C3)Cl
CHEMBL566162 mc3r_mouse Mouse No 4.5 EC50 = 33800 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
622 16 7 6 1.2 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C=CC3=CC(=CC=C3)Cl
CHEMBL365044 mc3r_human Human No 7.5 EC50 = 34.5 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
848 23 8 6 4.9 C1=CC=C(C=C1)CCCCC(=O)NC(CC2=CC=C(C=C2)Cl)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL365044 mc3r_human Human No 7.5 EC50 = 34.5 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
848 23 8 6 4.9 C1=CC=C(C=C1)CCCCC(=O)NC(CC2=CC=C(C=C2)Cl)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL405282 mc3r_mouse Mouse Yes 7.5 EC50 = 34.6 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
1571 49 23 21 -1.6 CC(C)C(C(=O)NC(CCSC)C(=O)NCC(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)O)NC(=O)C(CC6=CC=C(C=C6)O)N
CHEMBL405282 mc3r_mouse Mouse Yes 7.5 EC50 = 34.6 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
1571 49 23 21 -1.6 CC(C)C(C(=O)NC(CCSC)C(=O)NCC(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NCC(=O)O)NC(=O)C(CC6=CC=C(C=C6)O)N
CHEMBL378293 mc3r_human Human No 6.5 EC50 = 340 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
682 15 6 7 1.2 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3C(=O)NCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL378293 mc3r_human Human No 6.5 EC50 = 340 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
682 15 6 7 1.2 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3C(=O)NCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL2369966 mc3r_mouse Mouse No 5.5 EC50 = 3400 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1460 21 17 19 -3.1 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2CC3=CC=CC=C3CC2C(=O)NC(C(=O)N1)CC(=O)N)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL2369966 mc3r_mouse Mouse No 5.5 EC50 = 3400 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1460 21 17 19 -3.1 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2CC3=CC=CC=C3CC2C(=O)NC(C(=O)N1)CC(=O)N)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL105113 mc3r_mouse Mouse No 4.5 EC50 = 34000 Funct
Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)
702 18 10 8 -0.4 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL3287322 mc3r_mouse Mouse No 7.5 EC50 = 35 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
821 13 5 8 2.9 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)I)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC5=CC=C(C=C5)[N+](=O)[O-])C(=O)N
CHEMBL3287322 mc3r_mouse Mouse No 7.5 EC50 = 35 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
821 13 5 8 2.9 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)I)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC5=CC=C(C=C5)[N+](=O)[O-])C(=O)N
CHEMBL89270 mc3r_human Human No 6.5 EC50 = 350 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
644 17 9 7 -1.1 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)N
CHEMBL154153 mc3r_mouse Mouse No 5.5 EC50 = 3500 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
697 18 8 7 1.1 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=CC4=CC=CC=C43)C(=O)N
CHEMBL1093304 mc3r_human Human No 6.5 EC50 = 351 Funct
Agonist activity at human MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationAgonist activity at human MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulation
600 5 1 5 5.8 CC1=C(C=C2C(=C1)C(CC23CCN(CC3)C(=O)C4CN(CC4C5=C(C=C(C=C5)F)F)C(C)(C)C)C(C)(C)NC(=O)C)Cl
CHEMBL1093304 mc3r_human Human No 6.5 EC50 = 351 Funct
Agonist activity at human MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationAgonist activity at human MC3R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulation
600 5 1 5 5.8 CC1=C(C=C2C(=C1)C(CC23CCN(CC3)C(=O)C4CN(CC4C5=C(C=C(C=C5)F)F)C(C)(C)C)C(C)(C)NC(=O)C)Cl
CHEMBL410168 mc3r_human Human No 7.4 EC50 = 36 Funct
Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.
1528 30 20 19 -0.8 CC(C)C(C(=O)NC1CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC1=O)CC2=CNC=N2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC6=CC=CC=C6)C(=O)NCC(=O)N)NC(=O)C(CC7=CC=C(C=C7)O)N
CHEMBL1089461 mc3r_human Human No 5.4 EC50 = 3660 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
494 4 1 8 2.5 CC1CN(CC(C1(C2=CC=CC=N2)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C5=NN=CC=C5
CHEMBL1089461 mc3r_human Human No 5.4 EC50 = 3660 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
494 4 1 8 2.5 CC1CN(CC(C1(C2=CC=CC=N2)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C5=NN=CC=C5
CHEMBL1091150 mc3r_human Human No 5.4 EC50 = 3680 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
505 4 1 5 5.1 CC1CN(CC(C1(C2=CC=C(C=C2)Cl)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C
CHEMBL1091150 mc3r_human Human No 5.4 EC50 = 3680 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
505 4 1 5 5.1 CC1CN(CC(C1(C2=CC=C(C=C2)Cl)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C
CHEMBL446185 mc3r_human Human Yes 7.4 EC50 = 37 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
868 14 11 9 0.6 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5
CHEMBL378837 mc3r_human Human No 7.4 EC50 = 37 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
576 11 4 6 2.0 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)N3CCN(C(C3=O)CCCN=C(N)N)C(=O)C(CC4=CC=C(C=C4)F)N
CHEMBL446185 mc3r_human Human Yes 7.4 EC50 = 37 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
868 14 11 9 0.6 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5
CHEMBL378837 mc3r_human Human No 7.4 EC50 = 37 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
576 11 4 6 2.0 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)N3CCN(C(C3=O)CCCN=C(N)N)C(=O)C(CC4=CC=C(C=C4)F)N
CHEMBL203911 mc3r_human Human No 6.4 EC50 = 370 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
621 8 2 5 6.3 CC1COC(=O)N1CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6CCCCC6
CHEMBL2371962 mc3r_human Human No 6.4 EC50 = 370 Funct
Agonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulation
1055 14 10 10 3.5 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C2CCCCN2C(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=C(C=C4)C5=CC=CC=C5)CC6=CNC7=CC=CC=C76)C(=O)N)NC(=O)C
CHEMBL203911 mc3r_human Human No 6.4 EC50 = 370 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
621 8 2 5 6.3 CC1COC(=O)N1CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6CCCCC6
CHEMBL2371962 mc3r_human Human No 6.4 EC50 = 370 Funct
Agonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulationAgonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulation
1055 14 10 10 3.5 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C2CCCCN2C(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC=C(C=C4)C5=CC=CC=C5)CC6=CNC7=CC=CC=C76)C(=O)N)NC(=O)C
CHEMBL151906 mc3r_mouse Mouse No 5.4 EC50 = 3700 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
703 18 8 8 0.9 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CSC4=CC=CC=C43)C(=O)N
CHEMBL211419 mc3r_human Human No 5.4 EC50 = 3720 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
653 15 5 6 2.6 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL211419 mc3r_human Human No 5.4 EC50 = 3720 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
653 15 5 6 2.6 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL264190 mc3r_mouse Mouse Yes 7.4 EC50 = 38 Funct
Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL264190 mc3r_mouse Mouse Yes 7.4 EC50 = 38 Funct
Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL263878 mc3r_human Human No 7.4 EC50 = 39 Funct
Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.
1641 35 21 20 0.4 CCCCC(C(=O)NC1CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC1=O)CC2=CNC=N2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC6=CC=CC=C6)C(=O)NCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC7=CC=C(C=C7)O)N
CHEMBL91957 mc3r_human Human No 6.4 EC50 = 390 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
818 20 9 9 2.0 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)NS(=O)(=O)C5=CC=C(C=C5)Cl
CHEMBL1688104 mc3r_mouse Mouse Yes 5.4 EC50 = 3900 Funct
Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay
1636 24 20 21 0.6 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC2CSCC(=O)N(CC(NC2=O)CC3=CNC=N3)C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC4=CNC5=CC=CC=C54)CCCNC(=N)N)CC6=CC=CC=C6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)CC9=CC=CC=C9
CHEMBL1688104 mc3r_mouse Mouse Yes 5.4 EC50 = 3900 Funct
Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay
1636 24 20 21 0.6 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC2CSCC(=O)N(CC(NC2=O)CC3=CNC=N3)C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC4=CNC5=CC=CC=C54)CCCNC(=N)N)CC6=CC=CC=C6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)CC9=CC=CC=C9
CHEMBL276012 mc3r_human Human No 5.4 EC50 = 3900 Funct
In vitro effective concentration towards human Melanocortin-3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cellsIn vitro effective concentration towards human Melanocortin-3 receptor (MC3R) was determined by a SPA-based cAMP assay in melanoma cells
547 12 3 6 3.0 CCCC(=O)C1(CCN(CC1)C(=O)C(CC2=CC=C(C=C2)OC)NC(=O)C(CC3=CN=CN3)O)C4=CC=CC=C4
CHEMBL2369962 mc3r_mouse Mouse No 4.4 EC50 = 39200 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1398 21 17 19 -4.2 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)CC(=O)N)CCCN=C(N)N)CC3=CC=CC=C3)CC4=CNC=N4)NC(=O)C(CC5=CC=C(C=C5)O)N)C(CC6=CC=C(C=C6)O)C(=O)N)(C)C(=O)O)CC7=CC=CC=C7
CHEMBL2369962 mc3r_mouse Mouse No 4.4 EC50 = 39200 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1398 21 17 19 -4.2 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)CC(=O)N)CCCN=C(N)N)CC3=CC=CC=C3)CC4=CNC=N4)NC(=O)C(CC5=CC=C(C=C5)O)N)C(CC6=CC=C(C=C6)O)C(=O)N)(C)C(=O)O)CC7=CC=CC=C7
CHEMBL3601427 mc3r_human Human No 5.4 EC50 = 3930 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1130 17 9 11 2.0 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(N(C(=O)C(N(C(=O)C(N(C(=O)C(NC1=O)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL3601427 mc3r_human Human No 5.4 EC50 = 3930 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1130 17 9 11 2.0 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(N(C(=O)C(N(C(=O)C(N(C(=O)C(NC1=O)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL365794 mc3r_human Human No 5.4 EC50 = 3981.1 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
918 30 9 10 -0.4 CCCCC(C(=O)NCC(=O)N(CCCCN)CC(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL370321 mc3r_human Human No 5.4 EC50 = 3981.1 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 11 10 -0.6 CCCCC(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC(=O)N)NC(=O)C
CHEMBL365794 mc3r_human Human No 5.4 EC50 = 3981.1 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
918 30 9 10 -0.4 CCCCC(C(=O)NCC(=O)N(CCCCN)CC(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL370321 mc3r_human Human No 5.4 EC50 = 3981.1 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 11 10 -0.6 CCCCC(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC(=O)N)NC(=O)C
CHEMBL439128 mc3r_human Human No 8.4 EC50 = 4.2 Funct
Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.
1641 35 21 20 0.4 CCCCC(C(=O)NC1CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC1=O)CC2=CNC=N2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC6=CC=CC=C6)C(=O)NCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC7=CC=C(C=C7)O)N
CHEMBL384720 mc3r_human Human No 8.3 EC50 = 4.7 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
937 26 10 8 3.6 C1=CC=C(C=C1)CCCC(=O)NC(CC2=CN=CN2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)N
CHEMBL384720 mc3r_human Human No 8.3 EC50 = 4.7 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
937 26 10 8 3.6 C1=CC=C(C=C1)CCCC(=O)NC(CC2=CN=CN2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)N
CHEMBL431801 mc3r_human Human No 8.3 EC50 = 4.7 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
790 22 9 7 2.2 C1=CC=C(C=C1)CCCC(=O)NC(CC2=CN=CN2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL442829 mc3r_human Human No 7.4 EC50 = 40 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
616 11 3 6 4.5 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3CCCN3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL442829 mc3r_human Human No 7.4 EC50 = 40 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
616 11 3 6 4.5 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3CCCN3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL312998 mc3r_human Human No 7.4 EC50 = 40.5 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
792 21 10 8 1.3 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)NC(=O)C(CC5=CC=CC=C5)O
CHEMBL409049 mc3r_human Human No 6.4 EC50 = 400 Funct
Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.Intracellular cAMP accumulation in human Melanocortin 3 receptor functional assay.
1556 30 20 19 -0.2 CC(C)C(C(=O)NC1C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSC1(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CC=CC=C2)C(=O)NCC(=O)N)CC3=CNC4=CC=CC=C43)CCCN=C(N)N)CC5=CC=CC=C5)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N
CHEMBL407680 mc3r_human Human No 6.4 EC50 = 401 Funct
Effective concentration of peptide at 50% maximal cAMP generationEffective concentration of peptide at 50% maximal cAMP generation
1444 31 14 23 -6.3 CC(=O)C1CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2CCCN2C(=O)C(NC1=O)CCC(=O)O)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N6CCCC6C(=O)CN7CCCC7C(=O)CNC(CCCCN)C(=O)CNC(CC(=O)O)C(=O)N
CHEMBL2323788 mc3r_mouse Mouse Yes 5.4 EC50 = 4020 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1570 22 21 32 5.8 CC1C(=NC(C(=NC2CSCC(=O)N(CC(N=C2O)CCCNC(=N)N)C(C(=NC(C(=NC(C(=NC(C(=NC(CSSCC(C(=N1)O)N=C(C(CC3=CC=C(C=C3)O)N)O)C(=NC(CC4=CC=C(C=C4)O)C(=N)O)O)O)CC5=CC=CC=C5)O)C)O)CC(=N)O)O)CC6=CNC7=CC=CC=C76)O)CC8=CC=CC=C8)O
CHEMBL211975 mc3r_human Human No 7.4 EC50 = 41 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
558 11 4 5 1.9 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)N3CCN(C(C3=O)CCCN=C(N)N)C(=O)C(CC4=CC=CC=C4)N
CHEMBL365019 mc3r_human Human No 7.4 EC50 = 41 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
862 23 8 7 4.1 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CCCC(=O)C5=CC=CC=C5
CHEMBL211975 mc3r_human Human No 7.4 EC50 = 41 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
558 11 4 5 1.9 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)N3CCN(C(C3=O)CCCN=C(N)N)C(=O)C(CC4=CC=CC=C4)N
CHEMBL365019 mc3r_human Human No 7.4 EC50 = 41 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
862 23 8 7 4.1 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CCCC(=O)C5=CC=CC=C5
CHEMBL321870 mc3r_mouse Mouse No 5.4 EC50 = 4100 Funct
Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)
736 18 9 7 1.2 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC3=CC=CC=C32)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL1204056 mc3r_human Human No 5.4 EC50 = 4130 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
457 4 1 7 2.8 CC1CN(CC(C1(C2CC2)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C5=NN=CC=C5
CHEMBL1204056 mc3r_human Human No 5.4 EC50 = 4130 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
457 4 1 7 2.8 CC1CN(CC(C1(C2CC2)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C5=NN=CC=C5
CHEMBL3582446 mc3r_mouse Mouse No 6.4 EC50 = 415 Funct
Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay
700 19 9 7 -0.1 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)CC(=O)N
CHEMBL3582446 mc3r_mouse Mouse No 6.4 EC50 = 415 Funct
Agonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assayAgonist activity at mouse MC3 receptor expressed in HEK-293 cells assessed as cAMP response measured after 2 hrs incubation by cAMP Alphascreen assay
700 19 9 7 -0.1 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)CC(=O)N
CHEMBL273044 mc3r_mouse Mouse No 5.4 EC50 = 4160 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay
433 5 1 2 5.5 C1=CC=C(C=C1)CC2C(=O)N(C3=CC=CC=C3C(=O)N2)CC4=CC=CC=C4C5=CC=CC=C5
CHEMBL273044 mc3r_mouse Mouse No 5.4 EC50 = 4160 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as forskolin-stimulated response by beta-galactosidase reporter gene assay
433 5 1 2 5.5 C1=CC=C(C=C1)CC2C(=O)N(C3=CC=CC=C3C(=O)N2)CC4=CC=CC=C4C5=CC=CC=C5
CHEMBL209789 mc3r_human Human No 7.4 EC50 = 42 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
644 16 5 6 1.7 CC(=O)NC(CCC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)N2CC(CC2CCCN=C(N)N)OCC3=CC4=CC=CC=C4C=C3
CHEMBL209789 mc3r_human Human No 7.4 EC50 = 42 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
644 16 5 6 1.7 CC(=O)NC(CCC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)N2CC(CC2CCCN=C(N)N)OCC3=CC4=CC=CC=C4C=C3
CHEMBL3753126 mc3r_human Human No 7.4 EC50 = 42 Funct
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMXAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX
1220 17 13 11 3.3 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2CCCN2C(=O)C(NC1=O)CC3=CNC4=CC=CC=C43)CC5=CC6=CC=CC=C6C=C5)CCCN=C(N)N)CC7=CNC8=CC=CC=C87)C(=O)N)NC(=O)C
CHEMBL436903 mc3r_human Human No 4.4 EC50 = 42000 Funct
Inhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cellsInhibition of human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells
788 9 10 8 -0.4 CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCCCNC(=O)CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4
CHEMBL263234 mc3r_human Human No 7.4 EC50 = 43 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
806 20 8 6 3.8 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CC5=CC=CC=C5
CHEMBL263234 mc3r_human Human No 7.4 EC50 = 43 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
806 20 8 6 3.8 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)CC5=CC=CC=C5
CHEMBL382369 mc3r_human Human Yes 5.4 EC50 = 4300 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
860 15 11 10 0.3 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CCC(=O)O
CHEMBL382369 mc3r_human Human Yes 5.4 EC50 = 4300 Funct
Activity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulationActivity against hMC3R transfected in HEK293 cells by intracellular cAMP accumulation
860 15 11 10 0.3 CCCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CCC(=O)N1)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CCC(=O)O
CHEMBL399714 mc3r_human Human No 6.4 EC50 = 434 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
633 8 2 6 5.4 CN1C(=NN=N1)CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6=CC=C(C=C6)Cl
CHEMBL399714 mc3r_human Human No 6.4 EC50 = 434 Funct
Antagonist activity at human MC3R assessed as stimulation of cAMP productionAntagonist activity at human MC3R assessed as stimulation of cAMP production
633 8 2 6 5.4 CN1C(=NN=N1)CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6=CC=C(C=C6)Cl
CHEMBL50056 mc3r_mouse Mouse Yes 5.4 EC50 = 4370 Funct
Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL50056 mc3r_mouse Mouse Yes 5.4 EC50 = 4370 Funct
Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL569694 mc3r_mouse Mouse No 4.4 EC50 = 43700 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
604 18 7 6 0.8 C1=CC=C(C=C1)CCCC(=O)NC(CC2=CN=CN2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL569694 mc3r_mouse Mouse No 4.4 EC50 = 43700 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
604 18 7 6 0.8 C1=CC=C(C=C1)CCCC(=O)NC(CC2=CN=CN2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)N
CHEMBL453734 mc3r_human Human No 7.4 EC50 = 44 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
604 11 3 6 4.0 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C(C)(C)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL448410 mc3r_human Human No 7.4 EC50 = 44 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
630 11 3 6 4.8 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3CCCCN3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL453734 mc3r_human Human No 7.4 EC50 = 44 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
604 11 3 6 4.0 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C(C)(C)N)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL448410 mc3r_human Human No 7.4 EC50 = 44 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
630 11 3 6 4.8 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3CCCCN3)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL426282 mc3r_mouse Mouse No 7.4 EC50 = 44.8 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
798 26 9 7 4.1 CCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL426282 mc3r_mouse Mouse No 7.4 EC50 = 44.8 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
798 26 9 7 4.1 CCCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL64967 mc3r_mouse Mouse No 5.4 EC50 = 4400 Funct
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells
448 8 4 3 3.6 CC1CCN(CC1)CNC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)NCC4=CC=CC=C4
CHEMBL305132 mc3r_mouse Mouse No 5.4 EC50 = 4400 Funct
Agonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cellsAgonist activity on mouse Melanocortin 3 receptor (mMC3R) stably expressed in HEK cells
491 11 5 4 2.5 C1CN(CCC1NC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCCCCN)CC4=CC=CC=C4
CHEMBL317228 mc3r_mouse Mouse No 4.4 EC50 = 44000 Funct
Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)Agonist activity to the mouse Melanocortin-3 receptor (mMC3R)
672 17 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL184870 mc3r_human Human No 7.4 EC50 = 45 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
771 20 9 6 2.6 C=CCNC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL184870 mc3r_human Human No 7.4 EC50 = 45 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
771 20 9 6 2.6 C=CCNC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL406276 mc3r_human Human No 7.4 EC50 = 45 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
728 21 9 7 1.4 CCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL383719 mc3r_human Human No 6.4 EC50 = 450 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
669 8 2 6 6.2 CC1(CCN(S1(=O)=O)CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6CCCCC6)C
CHEMBL2369965 mc3r_mouse Mouse No 6.4 EC50 = 450 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1524 24 18 19 -1.3 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=C(C=C2)C3=CC=CC=C3)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL383719 mc3r_human Human No 6.4 EC50 = 450 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
669 8 2 6 6.2 CC1(CCN(S1(=O)=O)CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6CCCCC6)C
CHEMBL2369965 mc3r_mouse Mouse No 6.4 EC50 = 450 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1524 24 18 19 -1.3 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=C(C=C2)C3=CC=CC=C3)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL407825 mc3r_human Human No 6.4 EC50 = 450 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
700 19 9 7 0.5 CCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL2323789 mc3r_mouse Mouse Yes 5.4 EC50 = 4500 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1646 24 21 32 7.4 CC1C(=NC(C(=NC(CSSCC(C(=NC(C(=NC(C(=NC2CSCC(=O)N(CC(N=C2O)CCCNC(=N)N)C(C(=NC(C(=N1)O)CC(=N)O)O)CC3=CNC4=CC=CC=C43)O)CC5=CC=CC=C5)O)CC6=CC=CC=C6)O)N=C(C(CC7=CC=C(C=C7)O)N)O)C(=NC(CC8=CC=C(C=C8)O)C(=N)O)O)O)CC9=CC=CC=C9)O
CHEMBL364119 mc3r_human Human No 6.3 EC50 = 452 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
793 19 8 7 3.4 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C5=CC=CC=N5
CHEMBL364119 mc3r_human Human No 6.4 EC50 = 452 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
793 19 8 7 3.4 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C5=CC=CC=N5
CHEMBL1092550 mc3r_human Human No 5.3 EC50 = 4570 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
507 4 1 7 4.7 CC1CN(CC(C1(C2=C(C=CC=C2F)F)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C
CHEMBL1092550 mc3r_human Human No 5.3 EC50 = 4570 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
507 4 1 7 4.7 CC1CN(CC(C1(C2=C(C=CC=C2F)F)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C
CHEMBL434544 mc3r_human Human No 6.3 EC50 = 460 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
772 21 8 6 3.5 CCCCC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL434544 mc3r_human Human No 6.3 EC50 = 460 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
772 21 8 6 3.5 CCCCC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL1688111 mc3r_mouse Mouse Yes 5.3 EC50 = 4620 Funct
Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay
1636 24 22 33 5.6 CC1C(=NC(C(=NC(CSSCC(C(=NC(C(=NC(C(=NC2CSCC(=O)N(CC(N=C2O)CCCNC(=N)N)C(C(=NC(C(=N1)O)CC(=N)O)O)CC3=CNC4=CC=CC=C43)O)CC5=CC=CC=C5)O)CC6=CN=CN6)O)N=C(C(CC7=CC=C(C=C7)O)N)O)C(=NC(CC8=CC=C(C=C8)O)C(=N)O)O)O)CC9=CC=CC=C9)O
CHEMBL1688111 mc3r_mouse Mouse Yes 5.3 EC50 = 4620 Funct
Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay
1636 24 22 33 5.6 CC1C(=NC(C(=NC(CSSCC(C(=NC(C(=NC(C(=NC2CSCC(=O)N(CC(N=C2O)CCCNC(=N)N)C(C(=NC(C(=N1)O)CC(=N)O)O)CC3=CNC4=CC=CC=C43)O)CC5=CC=CC=C5)O)CC6=CN=CN6)O)N=C(C(CC7=CC=C(C=C7)O)N)O)C(=NC(CC8=CC=C(C=C8)O)C(=N)O)O)O)CC9=CC=CC=C9)O
CHEMBL3600840 mc3r_human Human No 6.3 EC50 = 463 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1102 17 11 11 1.6 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(N(C(=O)C(N(C(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL3600840 mc3r_human Human No 6.3 EC50 = 463 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1102 17 11 11 1.6 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(N(C(=O)C(N(C(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)C)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C(=O)N)NC(=O)C
CHEMBL3287324 mc3r_mouse Mouse No 7.3 EC50 = 47 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
840 15 6 8 1.9 CC(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)I)C(=O)N2CC3=CC=CC=C3CC2C(=O)NC(CC4=CC=C(C=C4)[N+](=O)[O-])C(=O)N
CHEMBL3287324 mc3r_mouse Mouse No 7.3 EC50 = 47 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
840 15 6 8 1.9 CC(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)I)C(=O)N2CC3=CC=CC=C3CC2C(=O)NC(CC4=CC=C(C=C4)[N+](=O)[O-])C(=O)N
CHEMBL3797690 mc3r_mouse Mouse No 7.3 EC50 = 47.4 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
1004 36 11 13 -1.2 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N
CHEMBL3797690 mc3r_mouse Mouse No 7.3 EC50 = 47.4 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
1004 36 11 13 -1.2 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N
CHEMBL359702 mc3r_human Human No 6.3 EC50 = 473 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
756 19 8 6 2.6 C1CC1C(=O)NC(CC2=CC=C(C=C2)Cl)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL359702 mc3r_human Human No 6.3 EC50 = 473 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
756 19 8 6 2.6 C1CC1C(=O)NC(CC2=CC=C(C=C2)Cl)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL2323795 mc3r_mouse Mouse Yes 7.3 EC50 = 49 Funct
Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assayAgonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay
1762 24 22 33 6.2 CC1C(=NC(C(=NC(CSSCC(C(=NC(C(=NC(C(=NC2CSCC(=O)N(CC(N=C2O)CCCNC(=N)N)C(C(=NC(C(=N1)O)CC(=N)O)O)CC3=CNC4=CC=CC=C43)O)CC5=CC=C(C=C5)I)O)CC6=CN=CN6)O)N=C(C(CC7=CC=C(C=C7)O)N)O)C(=NC(CC8=CC=C(C=C8)O)C(=N)O)O)O)CC9=CC=CC=C9)O
CHEMBL1092860 mc3r_human Human No 6.3 EC50 = 490 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
493 4 1 7 3.5 CC1CN(CC(C1(C2=CC=CC=C2)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C5=NN=CC=C5
CHEMBL1092860 mc3r_human Human No 6.3 EC50 = 490 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
493 4 1 7 3.5 CC1CN(CC(C1(C2=CC=CC=C2)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C5=NN=CC=C5
CHEMBL1688110 mc3r_mouse Mouse Yes 6.3 EC50 = 495 Funct
Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay
1636 24 20 21 0.6 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC2CSCC(=O)N(CC(NC2=O)CCCNC(=N)N)C(C(=O)NC(C(=O)N1)CC(=O)N)CC3=CNC4=CC=CC=C43)CC5=CC=CC=C5)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)CC9=CC=CC=C9
CHEMBL1688110 mc3r_mouse Mouse Yes 6.3 EC50 = 495 Funct
Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay
1636 24 20 21 0.6 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC2CSCC(=O)N(CC(NC2=O)CCCNC(=N)N)C(C(=O)NC(C(=O)N1)CC(=O)N)CC3=CNC4=CC=CC=C43)CC5=CC=CC=C5)CC6=CNC=N6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)CC9=CC=CC=C9
CHEMBL359701 mc3r_human Human No 6.3 EC50 = 497 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
758 19 8 6 3.2 CC(C)C(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL359701 mc3r_human Human No 6.3 EC50 = 497 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
758 19 8 6 3.2 CC(C)C(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL195439 mc3r_mouse Mouse No 8.3 EC50 = 5.1 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
784 25 9 7 3.5 CCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL195439 mc3r_mouse Mouse No 8.3 EC50 = 5.1 Funct
In vitro agonist potency for Mouse Melanocortin 3 receptorIn vitro agonist potency for Mouse Melanocortin 3 receptor
784 25 9 7 3.5 CCCCCCCCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL405791 mc3r_rat Rat No 8.3 EC50 = 5.2 Funct
Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)
1146 18 14 14 0.7 CC(C(C(=O)N)NC(=O)C1CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC5=CC=CC=C54)CC6=NC=CN6)NC(=O)C(CC7=CC=CC=C7)N)O
CHEMBL2372570 mc3r_human Human No 8.3 EC50 = 5.4 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
1024 17 12 11 -0.6 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=NC=NC2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
CHEMBL2372570 mc3r_human Human No 8.3 EC50 = 5.4 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
1024 17 12 11 -0.6 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=NC=NC2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N)NC(=O)C
CHEMBL2369963 mc3r_mouse Mouse No 8.3 EC50 = 5.6 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1498 23 18 19 -1.6 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL2369963 mc3r_mouse Mouse No 8.3 EC50 = 5.6 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1498 23 18 19 -1.6 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL214410 mc3r_human Human No 8.3 EC50 = 5.6 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
645 12 4 7 2.3 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)N3CCN(C(C3=O)CCCN=C(N)N)C(=O)C(CC4=CC=C(C=C4)F)N5CCNCC5
CHEMBL214410 mc3r_human Human No 8.3 EC50 = 5.6 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
645 12 4 7 2.3 CNC(=O)C(CC1=CC2=CC=CC=C2C=C1)N3CCN(C(C3=O)CCCN=C(N)N)C(=O)C(CC4=CC=C(C=C4)F)N5CCNCC5
CHEMBL508816 mc3r_human Human No 7.3 EC50 = 50 Funct
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation
944 11 10 11 2.4 C1C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2=C(S1)C=CC(=C2)[N+](=O)[O-])CC3=CN=CN3)CC4=CC5=CC=CC=C5C=C4)CCCN=C(N)N)CC6=CNC7=CC=CC=C76)C(=O)N
CHEMBL508816 mc3r_human Human No 7.3 EC50 = 50 Funct
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation
944 11 10 11 2.4 C1C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2=C(S1)C=CC(=C2)[N+](=O)[O-])CC3=CN=CN3)CC4=CC5=CC=CC=C5C=C4)CCCN=C(N)N)CC6=CNC7=CC=CC=C76)C(=O)N
CHEMBL1092571 mc3r_human Human No 6.3 EC50 = 500 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
469 4 1 5 4.4 CC1CN(CC(C1(C2=CC=CC=C2)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C5CCC5
CHEMBL1092571 mc3r_human Human No 6.3 EC50 = 500 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
469 4 1 5 4.4 CC1CN(CC(C1(C2=CC=CC=C2)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C5CCC5
CHEMBL190080 mc3r_human Human No 6.3 EC50 = 501.2 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
932 31 10 10 0.2 CCCCC(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCCN=C(N)N)CC(=O)N(CCC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL190080 mc3r_human Human No 6.3 EC50 = 501.2 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
932 31 10 10 0.2 CCCCC(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCCN=C(N)N)CC(=O)N(CCC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL190953 mc3r_human Human No 5.3 EC50 = 5011.9 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 10 10 -0.7 CCCCC(C(=O)NCC(=O)N(CCCCN)CC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C(=O)N(CC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL2371829 mc3r_human Human No 5.3 EC50 = 5011.9 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 10 10 -0.7 CCCCN(CC(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC(=O)N)C(=O)C
CHEMBL190953 mc3r_human Human No 5.3 EC50 = 5011.9 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 10 10 -0.7 CCCCC(C(=O)NCC(=O)N(CCCCN)CC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C(=O)N(CC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL2371829 mc3r_human Human No 5.3 EC50 = 5011.9 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 10 10 -0.7 CCCCN(CC(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NCC(=O)N)C(=O)C
CHEMBL504349 mc3r_human Human No 7.3 EC50 = 51 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
604 12 3 6 4.3 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C(C)NC)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL504349 mc3r_human Human No 7.3 EC50 = 51 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
604 12 3 6 4.3 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C(C)NC)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL3601429 mc3r_human Human No 5.3 EC50 = 5180 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1130 17 9 11 2.0 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(N(C(=O)C(NC(=O)C(N(C(=O)C(N(C1=O)C)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL3601429 mc3r_human Human No 5.3 EC50 = 5180 Funct
Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingAgonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting
1130 17 9 11 2.0 CCCCC(C(=O)NC1CC(=O)NCCCCC(N(C(=O)C(N(C(=O)C(NC(=O)C(N(C(=O)C(N(C1=O)C)CC2=CN=CN2)C)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N)C)CC5=CNC6=CC=CC=C65)C)C(=O)N)NC(=O)C
CHEMBL3421676 mc3r_human Human No 7.3 EC50 = 52 Funct
Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter
747 15 8 6 1.7 CC(=O)NC1CC2=C(CN(C1=O)C(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N)NC6=CC=CC=C26
CHEMBL452710 mc3r_human Human No 7.3 EC50 = 52 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
590 12 3 6 3.9 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)CNC)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL3421676 mc3r_human Human No 7.3 EC50 = 52 Funct
Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter
747 15 8 6 1.7 CC(=O)NC1CC2=C(CN(C1=O)C(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N)NC6=CC=CC=C26
CHEMBL452710 mc3r_human Human No 7.3 EC50 = 52 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
590 12 3 6 3.9 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)CNC)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL503449 mc3r_mouse Mouse No 6.3 EC50 = 525 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
700 18 9 7 0.4 CC1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)NC(=O)C
CHEMBL503449 mc3r_mouse Mouse No 6.3 EC50 = 525 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
700 18 9 7 0.4 CC1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)NC(=O)C
CHEMBL444219 mc3r_mouse Mouse No 7.3 EC50 = 53.7 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
704 18 9 8 0.1 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)F)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL444219 mc3r_mouse Mouse No 7.3 EC50 = 53.7 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
704 18 9 8 0.1 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)F)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL152555 mc3r_mouse Mouse No 4.3 EC50 = 53300 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
723 19 8 7 1.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)N
CHEMBL203975 mc3r_human Human No 6.3 EC50 = 540 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
641 8 2 6 5.6 C1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)CN6CCCS6(=O)=O
CHEMBL203975 mc3r_human Human No 6.3 EC50 = 540 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
641 8 2 6 5.6 C1CCC(CC1)C2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)CN6CCCS6(=O)=O
CHEMBL264190 mc3r_mouse Mouse Yes 5.3 EC50 = 5400 Funct
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cellsActivity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL211699 mc3r_human Human Yes 6.3 EC50 = 541 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
711 18 8 7 1.5 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL211699 mc3r_human Human Yes 6.3 EC50 = 541 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
711 18 8 7 1.5 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL211699 mc3r_human Human Yes 6.3 EC50 = 541 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
711 18 8 7 1.5 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL211699 mc3r_human Human Yes 6.3 EC50 = 541 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
711 18 8 7 1.5 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL507876 mc3r_human Human No 6.3 EC50 = 545 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
603 11 2 5 5.7 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C(C)(C)C)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL507876 mc3r_human Human No 6.3 EC50 = 545 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
603 11 2 5 5.7 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C(C)(C)C)C(CC3=CC4=CC=CC=C4C=C3)C(=O)NC
CHEMBL3421680 mc3r_human Human No 7.3 EC50 = 55 Funct
Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter
699 15 7 8 -0.9 CC(=O)NC1CN2C(=CN=N2)CN(C1=O)C(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL3287326 mc3r_mouse Mouse No 7.3 EC50 = 55 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
729 13 5 8 2.9 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)Cl)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC5=CC=C(C=C5)[N+](=O)[O-])C(=O)N
CHEMBL3421680 mc3r_human Human No 7.3 EC50 = 55 Funct
Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterActivity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter
699 15 7 8 -0.9 CC(=O)NC1CN2C(=CN=N2)CN(C1=O)C(CC3=CC=CC=C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL3287326 mc3r_mouse Mouse No 7.3 EC50 = 55 Funct
Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrsAgonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stimulatory response after 6 hrs
729 13 5 8 2.9 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)Cl)C(=O)N3CC4=CC=CC=C4CC3C(=O)NC(CC5=CC=C(C=C5)[N+](=O)[O-])C(=O)N
CHEMBL264190 mc3r_mouse Mouse Yes 7.3 EC50 = 55.5 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL264190 mc3r_mouse Mouse Yes 7.3 EC50 = 55.5 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayAgonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assay
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL380727 mc3r_human Human No 6.3 EC50 = 550 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
651 11 2 5 7.3 CCOC(=O)N(CC1(CCN(CC1)C(=O)C(CC2=CC=C(C=C2)Cl)NC(=O)C3CC4=CC=CC=C4CN3)C5CCCCC5)C(C)C
CHEMBL380727 mc3r_human Human No 6.3 EC50 = 550 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
651 11 2 5 7.3 CCOC(=O)N(CC1(CCN(CC1)C(=O)C(CC2=CC=C(C=C2)Cl)NC(=O)C3CC4=CC=CC=C4CN3)C5CCCCC5)C(C)C
CHEMBL2304248 mc3r_mouse Mouse No 5.3 EC50 = 5510 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay
2327 55 32 33 -6.4 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCNC(=N)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CC(=O)O)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)CC7=CC=CC=C7
CHEMBL2304248 mc3r_mouse Mouse No 5.3 EC50 = 5510 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay
2327 55 32 33 -6.4 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCNC(=N)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CC(=O)O)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)CC7=CC=CC=C7
CHEMBL183315 mc3r_human Human No 6.3 EC50 = 553 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
730 18 8 6 2.2 CC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL183315 mc3r_human Human No 6.3 EC50 = 553 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
730 18 8 6 2.2 CC(=O)NC(CC1=CC=C(C=C1)Cl)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL181494 mc3r_human Human No 6.3 EC50 = 556 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
792 19 8 6 3.8 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C5=CC=CC=C5
CHEMBL181494 mc3r_human Human No 6.3 EC50 = 556 Funct
Agonistic activity against human Melanocortin 3 receptorAgonistic activity against human Melanocortin 3 receptor
792 19 8 6 3.8 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C5=CC=CC=C5
CHEMBL506274 mc3r_human Human No 7.3 EC50 = 56 Funct
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation
905 11 9 11 2.3 C1C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2=C(S1)C=CC(=C2)[N+](=O)[O-])CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CC6=CC=CC=C6C=C5)C(=O)N
CHEMBL506274 mc3r_human Human No 7.3 EC50 = 56 Funct
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as cAMP accumulation
905 11 9 11 2.3 C1C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2=C(S1)C=CC(=C2)[N+](=O)[O-])CC3=CN=CN3)CC4=CC=CC=C4)CCCN=C(N)N)CC5=CC6=CC=CC=C6C=C5)C(=O)N
CHEMBL377779 mc3r_human Human No 6.3 EC50 = 563 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
673 16 6 7 0.3 CC(=O)NC(CCC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)N2CC(CC2C(=O)NCCN=C(N)N)OCC3=CC4=CC=CC=C4C=C3
CHEMBL377779 mc3r_human Human No 6.3 EC50 = 563 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
673 16 6 7 0.3 CC(=O)NC(CCC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)N2CC(CC2C(=O)NCCN=C(N)N)OCC3=CC4=CC=CC=C4C=C3
CHEMBL1092548 mc3r_human Human No 6.2 EC50 = 570 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
489 4 1 6 4.6 CC1CN(CC(C1(C2=CC(=CC=C2)F)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C
CHEMBL1092548 mc3r_human Human No 6.2 EC50 = 570 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
489 4 1 6 4.6 CC1CN(CC(C1(C2=CC(=CC=C2)F)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C
CHEMBL315258 mc3r_human Human No 6.2 EC50 = 570 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
716 20 9 8 -0.1 COCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL450236 mc3r_human Human No 7.2 EC50 = 58 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
630 11 3 6 4.5 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3(CCCC3)N)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL450236 mc3r_human Human No 7.2 EC50 = 58 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assayAgonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
630 11 3 6 4.5 CCCC1C(=O)N(CCN1C(=O)C(CC2=CC=C(C=C2)F)NC(=O)C3(CCCC3)N)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL328117 mc3r_human Human No 7.2 EC50 = 58 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
715 18 10 8 -0.7 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)NC(=O)C(=O)N
CHEMBL568577 mc3r_mouse Mouse No 4.2 EC50 = 58900 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
622 16 7 6 1.2 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C=CC3=CC=C(C=C3)Cl
CHEMBL568577 mc3r_mouse Mouse No 4.2 EC50 = 58900 Funct
Agonistic activity against mouse MC3RAgonistic activity against mouse MC3R
622 16 7 6 1.2 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C=CC3=CC=C(C=C3)Cl
CHEMBL140154 mc3r_human Human No 7.2 EC50 = 59 Funct
Evaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulationEvaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulation
604 8 2 6 5.8 CN1C(=NN=N1)CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6CCCCC6
CHEMBL2372365 mc3r_rat Rat No 7.2 EC50 = 59 Funct
Maximal agonist response at rat melanocortin 3 receptor (MC3R)Maximal agonist response at rat melanocortin 3 receptor (MC3R)
1082 17 13 14 0.6 CC(C(C(=O)N)NC(=O)C1CSSC(C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CNC3=CC=CC=C32)CCCN)CC4=CC=CC=C4)CC5=CN=CN5)NC(=O)C(CC6=CC=CC=C6)N)(C)C)O
CHEMBL381125 mc3r_human Human No 6.2 EC50 = 590 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
657 10 2 6 6.3 CC(C)N(CC1(CCN(CC1)C(=O)C(CC2=CC=C(C=C2)Cl)NC(=O)C3CC4=CC=CC=C4CN3)C5CCCCC5)S(=O)(=O)C
CHEMBL381125 mc3r_human Human No 6.2 EC50 = 590 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
657 10 2 6 6.3 CC(C)N(CC1(CCN(CC1)C(=O)C(CC2=CC=C(C=C2)Cl)NC(=O)C3CC4=CC=CC=C4CN3)C5CCCCC5)S(=O)(=O)C
CHEMBL375440 mc3r_human Human No 6.2 EC50 = 593 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
571 12 4 5 3.2 C1CC(NC1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL375440 mc3r_human Human No 6.2 EC50 = 593 Funct
Agonist activity at human MC3R transfected in HEK293 cellsAgonist activity at human MC3R transfected in HEK293 cells
571 12 4 5 3.2 C1CC(NC1)C(=O)NC(CC2=CC=CC=C2)C(=O)N3CC(CC3CCCN=C(N)N)OCC4=CC5=CC=CC=C5C=C4
CHEMBL384774 mc3r_human Human No 8.2 EC50 = 6 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
755 16 6 8 1.8 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)F)C(=O)N3CCN(C(=O)C3CCCN=C(N)N)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL384774 mc3r_human Human No 8.2 EC50 = 6 Funct
Agonist activity at human MC3RAgonist activity at human MC3R
755 16 6 8 1.8 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)F)C(=O)N3CCN(C(=O)C3CCCN=C(N)N)C(CC4=CC5=CC=CC=C5C=C4)C(=O)NC
CHEMBL24892 mc3r_human Human No 8.2 EC50 = 6 Funct
Agonistic activity against human melanocortin receptor (hMC3R) for cAMP accumulationAgonistic activity against human melanocortin receptor (hMC3R) for cAMP accumulation
953 15 12 10 0.2 CCCCC(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)N
CHEMBL419307 mc3r_human Human No 8.2 EC50 = 6 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
812 21 9 8 2.3 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)NC(=O)COC5=CC=C(C=C5)Cl
CHEMBL2304247 mc3r_mouse Mouse No 8.2 EC50 = 6.1 Funct
Displacement of MT2 from mouse MC3R expressed in HEK293 cellsDisplacement of MT2 from mouse MC3R expressed in HEK293 cells
2327 55 32 33 -6.4 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCNC(=N)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CC(=O)O)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)CC7=CC=CC=C7
CHEMBL2304247 mc3r_mouse Mouse No 8.2 EC50 = 6.1 Funct
Displacement of MT2 from mouse MC3R expressed in HEK293 cellsDisplacement of MT2 from mouse MC3R expressed in HEK293 cells
2327 55 32 33 -6.4 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCNC(=N)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CC(=O)O)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)CC7=CC=CC=C7
CHEMBL3350327 mc3r_mouse Mouse No 8.2 EC50 = 6.2 Funct
Displacement of MT2 from mouse MC3R expressed in HEK293 cellsDisplacement of MT2 from mouse MC3R expressed in HEK293 cells
2327 55 32 33 -6.4 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCNC(=N)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CC(=O)O)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)CC7=CC=CC=C7
CHEMBL3350327 mc3r_mouse Mouse No 8.2 EC50 = 6.2 Funct
Displacement of MT2 from mouse MC3R expressed in HEK293 cellsDisplacement of MT2 from mouse MC3R expressed in HEK293 cells
2327 55 32 33 -6.4 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCNC(=N)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CC(=O)O)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)CC7=CC=CC=C7
CHEMBL2369964 mc3r_mouse Mouse No 8.2 EC50 = 6.5 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1498 23 18 19 -1.6 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL2369964 mc3r_mouse Mouse No 8.2 EC50 = 6.5 Funct
Effective concentration for mouse Melanocortin-3 receptorEffective concentration for mouse Melanocortin-3 receptor
1498 23 18 19 -1.6 CC1C(=O)NC(C(=O)NC(N(C(=O)CC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CNC=N5)NC(=O)C(CC6=CC=C(C=C6)O)N)C(CC7=CC=C(C=C7)O)C(=O)N)(C)C(=O)O)CC8=CC=CC=C8
CHEMBL405335 mc3r_mouse Mouse No 8.2 EC50 = 6.8 Funct
Functional activity at the mouse melanocortin 3 receptorFunctional activity at the mouse melanocortin 3 receptor
1067 30 13 12 -0.4 CC(C)C(C(=O)N)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CN=CN5)NC(=O)C
CHEMBL1089483 mc3r_human Human No 6.2 EC50 = 600 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
493 4 1 7 3.9 CC1CN(CC(C1(C2=CC=CC=C2)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C5=NC=NC=C5
CHEMBL1089483 mc3r_human Human No 6.2 EC50 = 600 Funct
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayAgonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
493 4 1 7 3.9 CC1CN(CC(C1(C2=CC=CC=C2)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C5=NC=NC=C5
CHEMBL451423 mc3r_mouse Mouse No 6.2 EC50 = 615 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
731 18 9 9 -0.2 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)[N+](=O)[O-])C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL451423 mc3r_mouse Mouse No 6.2 EC50 = 615 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assayAgonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay
731 18 9 9 -0.2 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=C(C=C2)[N+](=O)[O-])C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL94391 mc3r_mouse Mouse No 5.2 EC50 = 6190 Funct
In vitro activation of mouse recombinant Melanocortin-3 receptor.In vitro activation of mouse recombinant Melanocortin-3 receptor.
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL509582 mc3r_human Human No 6.2 EC50 = 620 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
1072 14 12 11 0.9 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C2CC(CN2C(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC5=CC=CC=C5C=C4)N=C(N)N)CC6=CNC7=CC=CC=C76)C(=O)N)NC(=O)C
CHEMBL509582 mc3r_human Human No 6.2 EC50 = 620 Funct
Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelAgonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
1072 14 12 11 0.9 CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C2CC(CN2C(=O)C(NC(=O)C(NC1=O)CC3=CN=CN3)CC4=CC5=CC=CC=C5C=C4)N=C(N)N)CC6=CNC7=CC=CC=C76)C(=O)N)NC(=O)C
CHEMBL191063 mc3r_human Human No 6.2 EC50 = 631.0 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 10 10 -0.7 CCCCC(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL191063 mc3r_human Human No 6.2 EC50 = 631.0 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 10 10 -0.7 CCCCC(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL190732 mc3r_human Human No 5.2 EC50 = 6309.6 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
918 30 8 10 -0.8 CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)C(=O)C
CHEMBL189991 mc3r_human Human No 5.2 EC50 = 6309.6 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 9 10 -0.9 CCCCC(C(=O)NCC(=O)N(CCCCN)CC(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL190732 mc3r_human Human No 5.2 EC50 = 6309.6 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
918 30 8 10 -0.8 CCCCN(CC(=O)NCC(=O)N(CCCCN)CC(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)N(CCC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)C(=O)C
CHEMBL189991 mc3r_human Human No 5.2 EC50 = 6309.6 Funct
Effective concentration against human melanocortin receptor-3 expressed in 293 HEK cellsEffective concentration against human melanocortin receptor-3 expressed in 293 HEK cells
904 29 9 10 -0.9 CCCCC(C(=O)NCC(=O)N(CCCCN)CC(=O)NC(CC1=CC=CC=C1)C(=O)N(CCCN=C(N)N)CC(=O)N(CC2=CNC3=CC=CC=C32)CC(=O)NCC(=O)N)NC(=O)C
CHEMBL2448525 mc3r_mouse Mouse No 4.2 EC50 = 63300 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay
2327 55 32 33 -6.4 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCNC(=N)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CC(=O)O)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)CC7=CC=CC=C7
CHEMBL2448525 mc3r_mouse Mouse No 4.2 EC50 = 63300 Funct
Agonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assayAgonist activity at mouse MC3R expressed in HEK293 cells by beta-galactosidase assay
2327 55 32 33 -6.4 CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CC2=CC=CC=C2)CC3=CC=CC=C3)CCCNC(=N)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C5CCCN5C(=O)C(CC(=O)O)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)CC7=CC=CC=C7
CHEMBL264190 mc3r_mouse Mouse Yes 7.2 EC50 = 64 Funct
Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL264190 mc3r_mouse Mouse Yes 7.2 EC50 = 64 Funct
Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayAgonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assay
686 18 9 7 -0.3 CC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)N
CHEMBL204078 mc3r_human Human No 6.2 EC50 = 640 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
621 8 2 5 6.3 CC1COC(=O)N1CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6CCCCC6
CHEMBL204078 mc3r_human Human No 6.2 EC50 = 640 Funct
Activity against human MC3R by cAMP accumulationActivity against human MC3R by cAMP accumulation
621 8 2 5 6.3 CC1COC(=O)N1CC2(CCN(CC2)C(=O)C(CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)C6CCCCC6
CHEMBL88537 mc3r_human Human No 6.2 EC50 = 640 Funct
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R)
730 21 10 8 -0.4 C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)NC(=O)C(CC4=CN=CN4)NC(=O)CCCO