Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL3392057 npy1r_human Human Yes 5.0 EC50 = 10072 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
436 2 0 3 5.8 C1=CC=C2C(=C1)N=C3C(=N2)N(C(=N3)C4=CC(=CC=C4)Br)C5=CC=C(C=C5)Cl
CHEMBL3392057 npy1r_human Human Yes 5.0 EC50 = 10072 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
436 2 0 3 5.8 C1=CC=C2C(=C1)N=C3C(=N2)N(C(=N3)C4=CC(=CC=C4)Br)C5=CC=C(C=C5)Cl
CHEMBL3213459 npy1r_human Human Yes 5.0 EC50 = 10621 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
444 5 1 9 5.5 C1=CC(=CC(=C1)[N+](=O)[O-])NN=C(C(=O)C2=CC=C(C=C2)Br)C(=O)C(F)(F)F
CHEMBL3213459 npy1r_human Human Yes 5.0 EC50 = 10621 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
444 5 1 9 5.5 C1=CC(=CC(=C1)[N+](=O)[O-])NN=C(C(=O)C2=CC=C(C=C2)Br)C(=O)C(F)(F)F
CHEMBL1322039 npy1r_human Human Yes 5.0 EC50 = 10864 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
384 7 2 6 5.5 CCOC(=O)C1=NC2=CC=CC=C2C(=N1)NC3=CC=C(C=C3)NC4=CC=CC=C4
CHEMBL1322039 npy1r_human Human Yes 5.0 EC50 = 10864 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
384 7 2 6 5.5 CCOC(=O)C1=NC2=CC=CC=C2C(=N1)NC3=CC=C(C=C3)NC4=CC=CC=C4
CHEMBL1311742 npy1r_human Human Yes 5.0 EC50 = 11218 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
498 5 3 9 5.6 C1=CC(=C(C=C1NC(=S)NCCNC2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])Cl)Cl
CHEMBL1311742 npy1r_human Human Yes 5.0 EC50 = 11218 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
498 5 3 9 5.6 C1=CC(=C(C=C1NC(=S)NCCNC2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])Cl)Cl
CHEMBL1547757 npy1r_human Human Yes 4.9 EC50 = 11573 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
328 3 1 2 3.8 C1=CC=C(C=C1)CN2C(=CC(=N2)C3=CC=C(C=C3)Br)N
CHEMBL1547757 npy1r_human Human Yes 4.9 EC50 = 11573 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
328 3 1 2 3.8 C1=CC=C(C=C1)CN2C(=CC(=N2)C3=CC=C(C=C3)Br)N
CHEMBL1538224 npy1r_human Human Yes 4.9 EC50 = 11619 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
318 6 2 3 3.5 C1C(CC2=CC=CC=C21)NCC(COC3=CC=C(C=C3)Cl)O
CHEMBL1538224 npy1r_human Human Yes 4.9 EC50 = 11619 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
318 6 2 3 3.5 C1C(CC2=CC=CC=C21)NCC(COC3=CC=C(C=C3)Cl)O
CHEMBL1581332 npy1r_human Human Yes 4.9 EC50 = 11701 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
467 8 3 10 1.5 CCSC1=NN=C(S1)NC(=O)CCNS(=O)(=O)C2=CC(=CN=C2N)Br
CHEMBL1581332 npy1r_human Human Yes 4.9 EC50 = 11701 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
467 8 3 10 1.5 CCSC1=NN=C(S1)NC(=O)CCNS(=O)(=O)C2=CC(=CN=C2N)Br
CHEMBL3213319 npy1r_human Human No 4.9 EC50 = 12355 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
273 2 1 5 3.4 C1CSC2=C(C1=NNC3=CC=CC=N3)C=C(C=C2)F
CHEMBL3213319 npy1r_human Human No 4.9 EC50 = 12355 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
273 2 1 5 3.4 C1CSC2=C(C1=NNC3=CC=CC=N3)C=C(C=C2)F
CHEMBL1299267 npy1r_human Human Yes 4.9 EC50 = 12496 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
296 6 1 2 3.4 CCN(CC)CC(CN1C2=CC=CC=C2C3=CC=CC=C31)O
CHEMBL1299267 npy1r_human Human Yes 4.9 EC50 = 12496 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
296 6 1 2 3.4 CCN(CC)CC(CN1C2=CC=CC=C2C3=CC=CC=C31)O
CHEMBL1482637 npy1r_human Human Yes 4.9 EC50 = 12619 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
357 5 2 3 5.6 CC(=O)C(=NC1=C(C=C(C=C1)Cl)Cl)NNC2=CC(=CC=C2)Cl
CHEMBL1482637 npy1r_human Human Yes 4.9 EC50 = 12619 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
357 5 2 3 5.6 CC(=O)C(=NC1=C(C=C(C=C1)Cl)Cl)NNC2=CC(=CC=C2)Cl
CHEMBL1602800 npy1r_human Human Yes 4.9 EC50 = 12746 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
552 7 2 8 4.6 C1CCN(CC1)S(=O)(=O)C2=CC(=C(C=C2)Cl)NC(=O)C3=CC=CC=C3NS(=O)(=O)C4=CC=C(C=C4)F
CHEMBL1602800 npy1r_human Human Yes 4.9 EC50 = 12746 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
552 7 2 8 4.6 C1CCN(CC1)S(=O)(=O)C2=CC(=C(C=C2)Cl)NC(=O)C3=CC=CC=C3NS(=O)(=O)C4=CC=C(C=C4)F
CHEMBL1322039 npy1r_human Human Yes 4.9 EC50 = 13166 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
384 7 2 6 5.5 CCOC(=O)C1=NC2=CC=CC=C2C(=N1)NC3=CC=C(C=C3)NC4=CC=CC=C4
CHEMBL1322039 npy1r_human Human Yes 4.9 EC50 = 13166 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
384 7 2 6 5.5 CCOC(=O)C1=NC2=CC=CC=C2C(=N1)NC3=CC=C(C=C3)NC4=CC=CC=C4
CHEMBL1329027 npy1r_human Human Yes 4.9 EC50 = 13279 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
432 8 2 6 3.5 CCN(CC)S(=O)(=O)C1=CC2=C(C=C1)NC=C(C2=O)C(=O)NCCC3=CCCCC3
CHEMBL1329027 npy1r_human Human Yes 4.9 EC50 = 13279 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
432 8 2 6 3.5 CCN(CC)S(=O)(=O)C1=CC2=C(C=C1)NC=C(C2=O)C(=O)NCCC3=CCCCC3
CHEMBL1519588 npy1r_human Human Yes 4.9 EC50 = 13550 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
443 6 1 9 4.3 COC1=CC=C(C=C1)NC2=C(N=C(O2)C=C3C(=O)N(C(=S)S3)CC4CCCO4)C#N
CHEMBL1519588 npy1r_human Human Yes 4.9 EC50 = 13550 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
443 6 1 9 4.3 COC1=CC=C(C=C1)NC2=C(N=C(O2)C=C3C(=O)N(C(=S)S3)CC4CCCO4)C#N
CHEMBL2371911 npy1r_human Human Yes 5.9 EC50 = 1410 Funct
Agonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesisAgonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesis
1724 59 30 20 -0.4 CCCC(C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCCCC(C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)N)N)N
CHEMBL2371911 npy1r_human Human Yes 5.9 EC50 = 1410 Funct
Agonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesisAgonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesis
1724 59 30 20 -0.4 CCCC(C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCCCC(C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)N)N)N
CHEMBL3099723 npy1r_human Human No 6.8 EC50 = 144 Funct
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assayAgonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assay
4008 132 60 62 -15.6 CCC(C)C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)N2CCCC2C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)N3CCCC3C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC6=CN=CN6)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)OC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)N
CHEMBL526034 npy1r_human Human No 4.8 EC50 = 14724 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
281 4 1 2 5.0 C[NH+](C)CC1=C(C=CC2=C1C=C(O2)CC3=CC=CC=C3)[O-]
CHEMBL526034 npy1r_human Human No 4.8 EC50 = 14724 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
281 4 1 2 5.0 C[NH+](C)CC1=C(C=CC2=C1C=C(O2)CC3=CC=CC=C3)[O-]
CHEMBL1505552 npy1r_human Human Yes 4.8 EC50 = 14783 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
408 7 0 8 3.5 CCOC1=C(C=CC(=C1[N+](=O)[O-])C=C2C(=O)N(C(=S)S2)CC=C)OC(=O)C
CHEMBL1505552 npy1r_human Human Yes 4.8 EC50 = 14783 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
408 7 0 8 3.5 CCOC1=C(C=CC(=C1[N+](=O)[O-])C=C2C(=O)N(C(=S)S2)CC=C)OC(=O)C
CHEMBL1567983 npy1r_human Human Yes 4.8 EC50 = 15631 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
316 2 2 4 4.0 C1=CC=C(C(=C1)CN2C3=CC=CC=C3NC2=C4C=CC=CC4=O)O
CHEMBL1567983 npy1r_human Human Yes 4.8 EC50 = 15631 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
316 2 2 4 4.0 C1=CC=C(C(=C1)CN2C3=CC=CC=C3NC2=C4C=CC=CC4=O)O
CHEMBL1583097 npy1r_human Human Yes 4.8 EC50 = 15697 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
419 6 2 5 3.9 C1=CC=C(C(=C1)NS(=O)(=O)C2=CC=CC(=C2)NC(=O)CC3=CC=C(C=C3)Cl)F
CHEMBL1583097 npy1r_human Human Yes 4.8 EC50 = 15697 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
419 6 2 5 3.9 C1=CC=C(C(=C1)NS(=O)(=O)C2=CC=CC(=C2)NC(=O)CC3=CC=C(C=C3)Cl)F
CHEMBL3099724 npy1r_human Human No 6.8 EC50 = 164 Funct
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assayAgonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assay
4007 131 61 61 -16.2 CCC(C)C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)N2CCCC2C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)N3CCCC3C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC6=CN=CN6)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)N
CHEMBL1431189 npy1r_human Human Yes 4.8 EC50 = 16500 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
370 3 2 8 4.5 C1=CC(=C(C=C1NC(=O)CC(C(F)(F)F)(C(F)(F)F)O)Cl)Cl
CHEMBL1431189 npy1r_human Human Yes 4.8 EC50 = 16500 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
370 3 2 8 4.5 C1=CC(=C(C=C1NC(=O)CC(C(F)(F)F)(C(F)(F)F)O)Cl)Cl
CHEMBL1309183 npy1r_human Human Yes 4.8 EC50 = 16732 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
512 5 3 5 5.5 COC1=CC(=C(C=C1)NC(=S)NC(C(Cl)(Cl)Cl)NC(=O)C2=CC(=CC=C2)Cl)[N+](=O)[O-]
CHEMBL1309183 npy1r_human Human Yes 4.8 EC50 = 16732 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
512 5 3 5 5.5 COC1=CC(=C(C=C1)NC(=S)NC(C(Cl)(Cl)Cl)NC(=O)C2=CC(=CC=C2)Cl)[N+](=O)[O-]
CHEMBL1544847 npy1r_human Human Yes 4.8 EC50 = 17105 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
312 2 2 2 5.2 CC1=C(C=C(C=C1)Cl)NC(=O)C2=CC3=CC=CC=C3C=C2O
CHEMBL1544847 npy1r_human Human Yes 4.8 EC50 = 17105 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
312 2 2 2 5.2 CC1=C(C=C(C=C1)Cl)NC(=O)C2=CC3=CC=CC=C3C=C2O
CHEMBL1378687 npy1r_human Human Yes 4.8 EC50 = 17280 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
337 3 2 3 4.0 C1CCC2=C(C1)C(=C(S2)NC(=O)C3CC3)C4=NC5=CC=CC=C5N4
CHEMBL1378687 npy1r_human Human Yes 4.8 EC50 = 17280 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
337 3 2 3 4.0 C1CCC2=C(C1)C(=C(S2)NC(=O)C3CC3)C4=NC5=CC=CC=C5N4
CHEMBL1560379 npy1r_human Human No 4.7 EC50 = 18494 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
376 3 0 7 2.8 CCN1C(=O)C(=C(C(=N1)[N+](=O)[O-])C(C#N)C2=NC3=CC=CC=C3S2)Cl
CHEMBL1560379 npy1r_human Human No 4.7 EC50 = 18494 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
376 3 0 7 2.8 CCN1C(=O)C(=C(C(=N1)[N+](=O)[O-])C(C#N)C2=NC3=CC=CC=C3S2)Cl
CHEMBL1541596 npy1r_human Human Yes 4.7 EC50 = 18547 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
356 6 3 7 2.8 CCCC1=CC(=C2C(=CNN2)C3=CC=C(O3)C(=O)OCC)C(=O)C=C1O
CHEMBL1541596 npy1r_human Human Yes 4.7 EC50 = 18547 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
356 6 3 7 2.8 CCCC1=CC(=C2C(=CNN2)C3=CC=C(O3)C(=O)OCC)C(=O)C=C1O
CHEMBL1431891 npy1r_human Human Yes 4.7 EC50 = 18569 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
374 3 1 4 3.7 C1CCN(C1)C(=O)C2=CC=CC=C2NC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL1431891 npy1r_human Human Yes 4.7 EC50 = 18569 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
374 3 1 4 3.7 C1CCN(C1)C(=O)C2=CC=CC=C2NC(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
CHEMBL1537587 npy1r_human Human Yes 4.7 EC50 = 19303 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
359 5 1 5 2.7 CC1=CC2=C(C(=C1C)NS(=O)(=O)C)N=CN2CC3=CC=C(C=C3)OC
CHEMBL1537587 npy1r_human Human Yes 4.7 EC50 = 19303 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
359 5 1 5 2.7 CC1=CC2=C(C(=C1C)NS(=O)(=O)C)N=CN2CC3=CC=C(C=C3)OC
CHEMBL1345141 npy1r_human Human Yes 4.7 EC50 = 22043 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
443 3 1 5 4.3 C1CN(CC[NH+]1C2=NC3=CC=CC=C3C(=N2)C4=CC=CC=C4)C(=O)C5CC=CCC5C(=O)[O-]
CHEMBL1345141 npy1r_human Human Yes 4.7 EC50 = 22043 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
443 3 1 5 4.3 C1CN(CC[NH+]1C2=NC3=CC=CC=C3C(=N2)C4=CC=CC=C4)C(=O)C5CC=CCC5C(=O)[O-]
CHEMBL1517881 npy1r_human Human Yes 4.7 EC50 = 22163 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
453 3 0 7 4.2 CC1=C(C=C2C(=C1)C3=C(C(N2C(=O)CSC4=NCCS4)(C)C)SSC3=S)C
CHEMBL1517881 npy1r_human Human Yes 4.7 EC50 = 22163 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
453 3 0 7 4.2 CC1=C(C=C2C(=C1)C3=C(C(N2C(=O)CSC4=NCCS4)(C)C)SSC3=S)C
CHEMBL3099721 npy1r_human Human No 6.7 EC50 = 222 Funct
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assayAgonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assay
4008 132 60 62 -15.6 CCC(C)C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)N2CCCC2C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)N3CCCC3C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC6=CN=CN6)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)OC(CC8=CC=C(C=C8)O)C(=O)N)N
CHEMBL2371908 npy1r_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesisAgonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesis
1708 55 26 24 -5.3 CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CCCCC(C(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)O)N)N
CHEMBL2371908 npy1r_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesisAgonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesis
1708 55 26 24 -5.3 CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CCCCC(C(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)O)N)N
CHEMBL1302519 npy1r_human Human Yes 4.6 EC50 = 24391 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
357 3 2 4 4.4 C1CCC(CC1)N2C(=NNC2=S)C3=C(SC(=C3)C4=CC=CC=C4)N
CHEMBL1302519 npy1r_human Human Yes 4.6 EC50 = 24391 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
357 3 2 4 4.4 C1CCC(CC1)N2C(=NNC2=S)C3=C(SC(=C3)C4=CC=CC=C4)N
CHEMBL1392858 npy1r_human Human Yes 4.6 EC50 = 26411 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
488 9 2 7 2.9 CC(C1=NN=C(N1C)SCC(=O)NC2=CC=C(C=C2)C(=O)OC)NC(=O)C3=CC=CC=C3Cl
CHEMBL1392858 npy1r_human Human Yes 4.6 EC50 = 26411 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
488 9 2 7 2.9 CC(C1=NN=C(N1C)SCC(=O)NC2=CC=C(C=C2)C(=O)OC)NC(=O)C3=CC=CC=C3Cl
CHEMBL1418821 npy1r_human Human Yes 4.6 EC50 = 26506 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
407 5 2 6 3.9 C1C=CCC2C1C(=O)N(C2=O)C3=CC(=C(C=C3)NCCC4=CC=C(C=C4)O)[N+](=O)[O-]
CHEMBL1418821 npy1r_human Human Yes 4.6 EC50 = 26506 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
407 5 2 6 3.9 C1C=CCC2C1C(=O)N(C2=O)C3=CC(=C(C=C3)NCCC4=CC=C(C=C4)O)[N+](=O)[O-]
CHEMBL1465891 npy1r_human Human Yes 4.6 EC50 = 27316 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
414 4 4 6 4.2 CCOC1=CC=C(C=C1)NC(=S)NNC(=S)NC2=CC=CC(=C2)C(F)(F)F
CHEMBL1465891 npy1r_human Human Yes 4.6 EC50 = 27316 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
414 4 4 6 4.2 CCOC1=CC=C(C=C1)NC(=S)NNC(=S)NC2=CC=CC(=C2)C(F)(F)F
CHEMBL1447448 npy1r_human Human Yes 4.5 EC50 = 28902 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
251 2 1 2 3.2 CC(=O)NC1=CC=C(C=C1)C2=CC3=CC=CC=C3O2
CHEMBL1447448 npy1r_human Human Yes 4.5 EC50 = 28902 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
251 2 1 2 3.2 CC(=O)NC1=CC=C(C=C1)C2=CC3=CC=CC=C3O2
CHEMBL1995800 npy1r_human Human Yes 4.5 EC50 = 33309 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
288 4 2 8 3.4 C1=CC(=CC=C1NN=C(C#N)C(=S)N)OC(F)(F)F
CHEMBL1995800 npy1r_human Human Yes 4.5 EC50 = 33309 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
288 4 2 8 3.4 C1=CC(=CC=C1NN=C(C#N)C(=S)N)OC(F)(F)F
CHEMBL1336098 npy1r_human Human Yes 4.5 EC50 = 33757 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
314 4 1 6 3.6 C1=CC(=CC=C1OCC(=O)NC2=NC=C(S2)[N+](=O)[O-])Cl
CHEMBL1336098 npy1r_human Human Yes 4.5 EC50 = 33757 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
314 4 1 6 3.6 C1=CC(=CC=C1OCC(=O)NC2=NC=C(S2)[N+](=O)[O-])Cl
CHEMBL1504701 npy1r_human Human No 4.5 EC50 = 35337 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
464 4 2 12 6.3 C1=CC=C(C=C1)C(=O)NC(C(F)(F)F)(C(F)(F)F)NC2=NC3=C(S2)C=C(C=C3)[N+](=O)[O-]
CHEMBL1504701 npy1r_human Human No 4.5 EC50 = 35337 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
464 4 2 12 6.3 C1=CC=C(C=C1)C(=O)NC(C(F)(F)F)(C(F)(F)F)NC2=NC3=C(S2)C=C(C=C3)[N+](=O)[O-]
CHEMBL3099722 npy1r_human Human No 6.4 EC50 = 380 Funct
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assayAgonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assay
4008 132 60 62 -15.6 CCC(C)C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)N2CCCC2C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)N3CCCC3C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC6=CN=CN6)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)OC(CCCNC(=N)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)N
CHEMBL439904 npy1r_human Human Yes 8.3 EC50 = 5.6 Funct
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assayAgonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assay
4050 133 61 61 -14.9 CCC(C)C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)N2CCCC2C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)N3CCCC3C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC6=CN=CN6)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)N
CHEMBL1411397 npy1r_human Human Yes 5.3 EC50 = 5399 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
368 10 1 4 4.9 CCN(CC)C1=CC=C(C=C1)NC(=O)C(CC2=CC=CC=C2)C(=O)OCC
CHEMBL1411397 npy1r_human Human Yes 5.3 EC50 = 5399 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
368 10 1 4 4.9 CCN(CC)C1=CC=C(C=C1)NC(=O)C(CC2=CC=CC=C2)C(=O)OCC
CHEMBL1311742 npy1r_human Human Yes 5.2 EC50 = 5996 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
498 5 3 9 5.6 C1=CC(=C(C=C1NC(=S)NCCNC2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])Cl)Cl
CHEMBL1311742 npy1r_human Human Yes 5.2 EC50 = 5996 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
498 5 3 9 5.6 C1=CC(=C(C=C1NC(=S)NCCNC2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])Cl)Cl
CHEMBL1519263 npy1r_human Human Yes 5.2 EC50 = 6462 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
293 3 1 4 4.5 C1=CC2=NC(=C(N2C=C1)NC3=CC=C(C=C3)F)C4=CC=CO4
CHEMBL1519263 npy1r_human Human Yes 5.2 EC50 = 6462 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
293 3 1 4 4.5 C1=CC2=NC(=C(N2C=C1)NC3=CC=C(C=C3)F)C4=CC=CO4
CHEMBL1373205 npy1r_human Human Yes 5.2 EC50 = 6636 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
220 1 2 4 2.1 CC1=C(NC2=C1C=C(C=C2)[N+](=O)[O-])C(=O)O
CHEMBL1373205 npy1r_human Human Yes 5.2 EC50 = 6636 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
220 1 2 4 2.1 CC1=C(NC2=C1C=C(C=C2)[N+](=O)[O-])C(=O)O
CHEMBL1411397 npy1r_human Human Yes 5.2 EC50 = 7050 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
368 10 1 4 4.9 CCN(CC)C1=CC=C(C=C1)NC(=O)C(CC2=CC=CC=C2)C(=O)OCC
CHEMBL1411397 npy1r_human Human Yes 5.2 EC50 = 7050 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
368 10 1 4 4.9 CCN(CC)C1=CC=C(C=C1)NC(=O)C(CC2=CC=CC=C2)C(=O)OCC
CHEMBL1573719 npy1r_human Human Yes 5.2 EC50 = 7053 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
175 1 2 5 1.8 C(#N)C1=C(SN=C1Cl)NN
CHEMBL1573719 npy1r_human Human Yes 5.2 EC50 = 7053 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
175 1 2 5 1.8 C(#N)C1=C(SN=C1Cl)NN
CHEMBL1301994 npy1r_human Human Yes 5.1 EC50 = 7164 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
444 6 2 6 4.2 CCN1C(=NN=C1SCC(=O)NC2=CC3=C(C=C2)C4=CC=CC=C4O3)C5=CC=C(C=C5)N
CHEMBL1301994 npy1r_human Human Yes 5.2 EC50 = 7164 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
444 6 2 6 4.2 CCN1C(=NN=C1SCC(=O)NC2=CC3=C(C=C2)C4=CC=CC=C4O3)C5=CC=C(C=C5)N
CHEMBL1374954 npy1r_human Human Yes 5.1 EC50 = 7410 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
432 5 2 4 5.7 C1=CC=C(C=C1)C2=C(N(N=C2CSC3=NC4=CC=CC=C4N3)C5=CC=C(C=C5)Cl)N
CHEMBL1572588 npy1r_human Human Yes 5.1 EC50 = 7410 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
446 4 2 5 3.7 C1CN(CCC1NC(=O)NC2=C(C=C(C=C2)Cl)Cl)S(=O)(=O)C3=CC=C(C=C3)F
CHEMBL1374954 npy1r_human Human Yes 5.1 EC50 = 7410 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
432 5 2 4 5.7 C1=CC=C(C=C1)C2=C(N(N=C2CSC3=NC4=CC=CC=C4N3)C5=CC=C(C=C5)Cl)N
CHEMBL1572588 npy1r_human Human Yes 5.1 EC50 = 7410 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
446 4 2 5 3.7 C1CN(CCC1NC(=O)NC2=C(C=C(C=C2)Cl)Cl)S(=O)(=O)C3=CC=C(C=C3)F
CHEMBL1548605 npy1r_human Human Yes 5.1 EC50 = 8504 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
367 8 1 4 4.3 CC1=CC=C(C=C1)N2CCN(CC2)CC(COC3=CC=CC=C3CC=C)O
CHEMBL1548605 npy1r_human Human Yes 5.1 EC50 = 8504 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
367 8 1 4 4.3 CC1=CC=C(C=C1)N2CCN(CC2)CC(COC3=CC=CC=C3CC=C)O
CHEMBL3194195 npy1r_human Human Yes 5.0 EC50 = 9377 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
284 4 1 4 5.8 C1=CC=C(C=C1)C(=O)C(=NNC2=CC=C(C=C2)Cl)C#N
CHEMBL3194195 npy1r_human Human Yes 5.0 EC50 = 9377 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
284 4 1 4 5.8 C1=CC=C(C=C1)C(=O)C(=NNC2=CC=C(C=C2)Cl)C#N
CHEMBL1312767 npy1r_human Human Yes 5.0 EC50 = 9709 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
328 3 1 4 3.8 CN1C=C(C(=N1)C(=O)NC2=CC=C(C=C2)C3CCCCC3)[N+](=O)[O-]
CHEMBL1312767 npy1r_human Human Yes 5.0 EC50 = 9709 Funct
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
328 3 1 4 3.8 CN1C=C(C(=N1)C(=O)NC2=CC=C(C=C2)C3CCCCC3)[N+](=O)[O-]
CHEMBL496 npy1r_human Human Yes 5.0 EC50 = 9796 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
407 2 2 2 7.5 C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl
CHEMBL496 npy1r_human Human Yes 5.0 EC50 = 9796 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
407 2 2 2 7.5 C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl
CHEMBL1471202 npy1r_human Human Yes 5.0 EC50 = 9924 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
322 4 1 5 2.5 CC1=NC(=O)C(N1C2=CC=CC=C2)N=NC3=CC=CC=C3C(=O)O
CHEMBL1471202 npy1r_human Human Yes 5.0 EC50 = 9924 Funct
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
322 4 1 5 2.5 CC1=NC(=O)C(N1C2=CC=CC=C2)N=NC3=CC=CC=C3C(=O)O
CHEMBL269503 npy1r_human Human No 10.7 IC50 = 0.0 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
4242 131 59 65 -15.5 CC(C)CC(C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC=N3)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C6CCCN6C(=O)C(CO)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(C)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL508974 npy1r_human Human No 10.3 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 10.3 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 10.3 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 10.3 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 10.2 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 10.2 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL438945 npy1r_human Human Yes 10.2 IC50 = 0.1 Funct
Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assayBinding affinity to human neuropeptide Y1 receptor by radioligand displacement assay
4272 132 59 65 -17.7 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL511460 npy1r_human Human No 10.0 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
545 13 6 5 3.4 CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL3746870 npy1r_human Human No 10.0 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL511460 npy1r_human Human No 10.0 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
545 13 6 5 3.4 CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL3746870 npy1r_human Human No 10.0 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL3746870 npy1r_human Human No 10.0 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL3746870 npy1r_human Human No 10.0 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL511460 npy1r_human Human No 9.9 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
545 13 6 5 3.4 CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL511460 npy1r_human Human No 9.9 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
545 13 6 5 3.4 CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 9.9 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 9.9 IC50 = 0.1 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL567112 npy1r_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
474 9 1 9 4.2 CCC1=C(N=C(S1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=CC=CC(=N4)C)CF
CHEMBL567112 npy1r_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
474 9 1 9 4.2 CCC1=C(N=C(S1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=CC=CC(=N4)C)CF
CHEMBL3746870 npy1r_human Human No 9.8 IC50 = 0.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 9.8 IC50 = 0.2 Funct
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL3746870 npy1r_human Human No 9.8 IC50 = 0.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 9.8 IC50 = 0.2 Funct
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL585669 npy1r_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
442 7 1 8 4.2 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC(=C(O3)C)C)N4CCSCC4
CHEMBL585669 npy1r_human Human No 9.8 IC50 = 0.2 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
442 7 1 8 4.2 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC(=C(O3)C)C)N4CCSCC4
CHEMBL3746870 npy1r_human Human No 9.8 IC50 = 0.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL3746870 npy1r_human Human No 9.8 IC50 = 0.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 9.8 IC50 = 0.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL267633 npy1r_human Human No 9.8 IC50 = 0.2 Funct
Displacement of radiolabeled NPY from human neuropeptide Y1 receptorDisplacement of radiolabeled NPY from human neuropeptide Y1 receptor
4254 131 59 64 -17.0 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL3745739 npy1r_human Human No 9.8 IC50 = 0.2 Funct
Displacement of radiolabeled NPY from human neuropeptide Y1 receptorDisplacement of radiolabeled NPY from human neuropeptide Y1 receptor
4254 131 59 64 -17.0 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL508974 npy1r_human Human No 9.8 IC50 = 0.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL585711 npy1r_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
460 8 1 9 3.8 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC(=C(S3)C)CF)N4CCOCC4
CHEMBL585711 npy1r_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
460 8 1 9 3.8 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC(=C(S3)C)CF)N4CCOCC4
CHEMBL438945 npy1r_human Human Yes 9.7 IC50 = 0.2 Funct
Displacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting methodDisplacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting method
4272 132 59 65 -17.7 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL511460 npy1r_human Human No 9.6 IC50 = 0.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
545 13 6 5 3.4 CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL511460 npy1r_human Human No 9.6 IC50 = 0.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
545 13 6 5 3.4 CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL566020 npy1r_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
446 7 1 9 4.2 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCSCC3)NCC4=NC(=CC=C4)F)C
CHEMBL566041 npy1r_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
442 7 1 8 4.0 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC(=C(S3)C)C)N4CCOCC4
CHEMBL566020 npy1r_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
446 7 1 9 4.2 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCSCC3)NCC4=NC(=CC=C4)F)C
CHEMBL566041 npy1r_human Human No 9.6 IC50 = 0.3 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
442 7 1 8 4.0 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC(=C(S3)C)C)N4CCOCC4
CHEMBL3746870 npy1r_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL3746870 npy1r_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL567101 npy1r_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
440 8 1 8 3.8 CCC1=C(N=C(O1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=CC=CC(=N4)C)C
CHEMBL567101 npy1r_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
440 8 1 8 3.8 CCC1=C(N=C(O1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=CC=CC(=N4)C)C
CHEMBL508974 npy1r_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL566040 npy1r_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
452 7 1 8 3.6 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC4=C(O3)CCCC4)N5CCOCC5
CHEMBL566040 npy1r_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
452 7 1 8 3.6 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC4=C(O3)CCCC4)N5CCOCC5
CHEMBL511460 npy1r_human Human No 9.3 IC50 = 0.5 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
545 13 6 5 3.4 CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL511460 npy1r_human Human No 9.3 IC50 = 0.5 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
545 13 6 5 3.4 CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL3746870 npy1r_human Human No 9.3 IC50 = 0.5 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL3746870 npy1r_human Human No 9.3 IC50 = 0.5 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL566255 npy1r_human Human No 9.3 IC50 = 0.6 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
460 8 1 9 3.8 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC(=C(S3)CF)C)N4CCOCC4
CHEMBL566255 npy1r_human Human No 9.3 IC50 = 0.6 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
460 8 1 9 3.8 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC(=C(S3)CF)C)N4CCOCC4
CHEMBL567719 npy1r_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
426 7 1 8 3.4 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC(=C(O3)C)C)N4CCOCC4
CHEMBL567719 npy1r_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
426 7 1 8 3.4 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC(=C(O3)C)C)N4CCOCC4
CHEMBL508974 npy1r_human Human No 9.2 IC50 = 0.7 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 9.2 IC50 = 0.7 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL267633 npy1r_human Human No 9.0 IC50 = 1.0 Funct
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
4254 131 59 64 -17.0 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL3745739 npy1r_human Human No 9.0 IC50 = 1.0 Funct
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
4254 131 59 64 -17.0 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL267633 npy1r_human Human No 9.0 IC50 = 1.0 Funct
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
4254 131 59 64 -17.0 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL3745739 npy1r_human Human No 9.0 IC50 = 1.0 Funct
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
4254 131 59 64 -17.0 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL438945 npy1r_human Human Yes 8.9 IC50 = 1.2 Funct
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
4272 132 59 65 -17.7 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL438945 npy1r_human Human Yes 8.9 IC50 = 1.2 Funct
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
4272 132 59 65 -17.7 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL511460 npy1r_human Human No 8.9 IC50 = 1.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
545 13 6 5 3.4 CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL511460 npy1r_human Human No 8.9 IC50 = 1.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
545 13 6 5 3.4 CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL564536 npy1r_human Human Yes 8.9 IC50 = 1.4 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
572 11 2 8 6.4 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)N3CCOCC3)NC(C)C4=CC(=CC(=C4)Cl)NC(=O)OC(C)C)C
CHEMBL50184 npy1r_human Human No 8.9 IC50 = 1.4 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
558 11 2 8 6.0 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)N3CCOCC3)NCC4=CC(=CC(=C4)Cl)NC(=O)OC(C)C)C
CHEMBL564536 npy1r_human Human Yes 8.9 IC50 = 1.4 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
572 11 2 8 6.4 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)N3CCOCC3)NC(C)C4=CC(=CC(=C4)Cl)NC(=O)OC(C)C)C
CHEMBL3746870 npy1r_human Human No 8.8 IC50 = 1.4 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL3746870 npy1r_human Human No 8.8 IC50 = 1.4 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
617 17 6 7 3.3 CCOC(=O)CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL567928 npy1r_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
430 7 1 9 3.4 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=NC(=CC=C4)F)C
CHEMBL567928 npy1r_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
430 7 1 9 3.4 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=NC(=CC=C4)F)C
CHEMBL566889 npy1r_human Human No 8.8 IC50 = 1.7 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
474 7 1 9 2.9 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC(=C(O3)C)C)N4CCS(=O)(=O)CC4
CHEMBL566889 npy1r_human Human No 8.8 IC50 = 1.7 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
474 7 1 9 2.9 CC1=NC(=CC=C1)CNC2=CC(=CC(=N2)CSC3=NC(=C(O3)C)C)N4CCS(=O)(=O)CC4
CHEMBL61532 npy1r_rat Rat No 8.8 IC50 = 1.7 Funct
The compound was tested for the binding affinity against Neuropeptide Y receptor type 1 in ratThe compound was tested for the binding affinity against Neuropeptide Y receptor type 1 in rat
525 12 1 5 5.7 C1CCN(CC1)CCCOC2=CC=CC3=C2N=C(N3CCCC4CCCNC4)COC5=CC=C(C=C5)Cl
CHEMBL567941 npy1r_human Human No 8.7 IC50 = 1.8 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
444 8 1 9 3.1 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=NC(=CC=C4)CF)C
CHEMBL567941 npy1r_human Human No 8.8 IC50 = 1.8 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
444 8 1 9 3.1 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=NC(=CC=C4)CF)C
CHEMBL566664 npy1r_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
488 11 1 10 3.0 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=NC(=CC=C4)COCCF)C
CHEMBL566664 npy1r_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
488 11 1 10 3.0 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=NC(=CC=C4)COCCF)C
CHEMBL332347 npy1r_human Human Yes 8.0 IC50 = 10.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
474 11 5 4 2.5 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O
CHEMBL332347 npy1r_human Human Yes 8.0 IC50 = 10.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
474 11 5 4 2.5 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O
CHEMBL381510 npy1r_human Human No 7.0 IC50 = 100 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
524 5 1 5 5.5 CC1(CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5)OC6=CC=C(C=C6)Cl)F
CHEMBL381510 npy1r_human Human No 7.0 IC50 = 100 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
524 5 1 5 5.5 CC1(CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5)OC6=CC=C(C=C6)Cl)F
CHEMBL417711 npy1r_human Human No 7.0 IC50 = 100 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
526 11 4 3 4.1 C1=CC=C(C=C1)CNC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl
CHEMBL17450 npy1r_human Human No 6.0 IC50 = 1000 Funct
Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1
474 13 2 8 7.5 CCCCN(CCCC)CCCNC1=NC2=CC=CC=C2C(=N1)NC3=CC=CC(=C3)C(F)(F)F
CHEMBL42793 npy1r_human Human No 6.0 IC50 = 1000 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
500 10 5 4 2.9 C1CC2=C(C1NC(=O)C(CCCN=C(N)N)NC(=O)C(C3=CC=CC=C3)C4=CC=CC=C4)C=CC(=C2)O
CHEMBL1493277 npy1r_human Human Yes 5.0 IC50 = 10300 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
368 5 1 2 5.3 CC(C(=O)NC1=CC=CC=C1C2=CC=CC=C2)SC3=CC=C(C=C3)Cl
CHEMBL1493277 npy1r_human Human Yes 5.0 IC50 = 10300 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
368 5 1 2 5.3 CC(C(=O)NC1=CC=CC=C1C2=CC=CC=C2)SC3=CC=C(C=C3)Cl
CHEMBL3194054 npy1r_human Human Yes 5.0 IC50 = 10390 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
539 12 2 8 3.1 CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N(CCC2=CC=CC=C2)CC(=O)NN=CC3=CC(=C(C=C3)OC)OC
CHEMBL3194054 npy1r_human Human Yes 5.0 IC50 = 10390 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
539 12 2 8 3.1 CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N(CCC2=CC=CC=C2)CC(=O)NN=CC3=CC(=C(C=C3)OC)OC
CHEMBL1385608 npy1r_human Human Yes 5.0 IC50 = 10400 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
529 14 0 2 7.8 C1=CC=C(C=C1)P(=O)(CCCCCCCCCP(=O)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1385608 npy1r_human Human Yes 5.0 IC50 = 10400 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
529 14 0 2 7.8 C1=CC=C(C=C1)P(=O)(CCCCCCCCCP(=O)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL2004475 npy1r_human Human No 5.0 IC50 = 10590 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
529 2 3 5 3.7 CC1CC=CC2C3C(O3)(C(C4C2(C(=O)C=CC(=O)C(C(=C1)C)O)C(=O)NC4CC5=CNC6=CC=CC=C65)C)C
CHEMBL2004475 npy1r_human Human No 5.0 IC50 = 10590 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
529 2 3 5 3.7 CC1CC=CC2C3C(O3)(C(C4C2(C(=O)C=CC(=O)C(C(=C1)C)O)C(=O)NC4CC5=CNC6=CC=CC=C65)C)C
CHEMBL1426722 npy1r_human Human Yes 5.0 IC50 = 10620 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
404 7 1 4 4.1 CC1=CC=C(C=C1)N2C=C(C(=N2)C3=CC=C(C=C3)F)CNCCN4C(=CC(=N4)C)C
CHEMBL1426722 npy1r_human Human Yes 5.0 IC50 = 10620 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
404 7 1 4 4.1 CC1=CC=C(C=C1)N2C=C(C(=N2)C3=CC=C(C=C3)F)CNCCN4C(=CC(=N4)C)C
CHEMBL238729 npy1r_human Human No 7.0 IC50 = 107 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
517 5 1 4 5.0 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCCNC5)OC6=CC=C(C=C6)Cl
CHEMBL238729 npy1r_human Human No 7.0 IC50 = 107 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
517 5 1 4 5.0 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCCNC5)OC6=CC=C(C=C6)Cl
CHEMBL411800 npy1r_human Human Yes 6.0 IC50 = 1091 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1917 66 32 26 -4.1 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CNC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)C(C)O)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL392943 npy1r_human Human No 8.0 IC50 = 11 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
531 5 0 4 5.5 CN1CCC(CC1)CN2C3=CC=CC=C3C4=CC(=CC(=C42)OC5=CC=C(C=C5)Cl)C(=O)N6CCN(CC6)C
CHEMBL52282 npy1r_human Human No 8.0 IC50 = 11 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
543 12 2 7 7.1 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OC3CCC3)NCC4=CC(=CC(=C4)Cl)NC(=O)OC(C)C)C
CHEMBL264820 npy1r_human Human No 8.0 IC50 = 11 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
557 12 2 7 7.5 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OC3CCCC3)NCC4=CC(=CC(=C4)Cl)NC(=O)OC(C)C)C
CHEMBL392943 npy1r_human Human No 8.0 IC50 = 11 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
531 5 0 4 5.5 CN1CCC(CC1)CN2C3=CC=CC=C3C4=CC(=CC(=C42)OC5=CC=C(C=C5)Cl)C(=O)N6CCN(CC6)C
CHEMBL332347 npy1r_human Human Yes 7.9 IC50 = 11.8 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
474 11 5 4 2.5 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O
CHEMBL332347 npy1r_human Human Yes 7.9 IC50 = 11.8 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
474 11 5 4 2.5 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O
CHEMBL441007 npy1r_human Human No 7.0 IC50 = 110 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
3840 131 64 54 -11.5 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCCNC(=N)N)NC(=O)C(CSSCC(C(=O)NC(CCCNC(=N)N)C(=O)NC(CC4=CN=CN4)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)N)NC(=O)C(CO)NC(=O)C(C)NC(=O)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL289620 npy1r_human Human No 7.0 IC50 = 110 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
458 11 4 3 2.9 C1=CC=C(C=C1)CNC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL43627 npy1r_human Human No 6.0 IC50 = 1100 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
532 9 3 3 4.1 C1CC2=CC=CC=C2CN(C1)C(=O)C(CCCN=C(N)N)NC(=O)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl
CHEMBL1349920 npy1r_human Human Yes 5.0 IC50 = 11150 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
244 3 0 4 3.1 CCSC1=NC2=C(C=C(C=C2)OC)C=C1C#N
CHEMBL1349920 npy1r_human Human Yes 5.0 IC50 = 11150 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
244 3 0 4 3.1 CCSC1=NC2=C(C=C(C=C2)OC)C=C1C#N
CHEMBL1342128 npy1r_human Human Yes 5.0 IC50 = 11350 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
327 4 0 6 3.7 C1COC2=C(O1)C=CC(=C2)C(=O)CSC3=NC4=CC=CC=C4O3
CHEMBL1342128 npy1r_human Human Yes 5.0 IC50 = 11350 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
327 4 0 6 3.7 C1COC2=C(O1)C=CC(=C2)C(=O)CSC3=NC4=CC=CC=C4O3
CHEMBL41392 npy1r_human Human No 4.9 IC50 = 11500 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
473 12 4 4 2.3 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCCC3=CC=CC=N3
CHEMBL1423382 npy1r_human Human Yes 4.9 IC50 = 11510 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
444 9 0 6 5.5 CCC(C(=O)OCC1=CC=CC=C1)OC2=CC3=C(C=C2)C(=O)C(=CO3)C4=CC=CC=C4OC
CHEMBL1423382 npy1r_human Human Yes 4.9 IC50 = 11510 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
444 9 0 6 5.5 CCC(C(=O)OCC1=CC=CC=C1)OC2=CC3=C(C=C2)C(=O)C(=CO3)C4=CC=CC=C4OC
CHEMBL1456185 npy1r_human Human Yes 4.9 IC50 = 11810 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
254 4 1 4 3.4 C=CCNC1=NC(=NC2=CC=CC=C21)N3CCCC3
CHEMBL1456185 npy1r_human Human Yes 4.9 IC50 = 11810 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
254 4 1 4 3.4 C=CCNC1=NC(=NC2=CC=CC=C21)N3CCCC3
CHEMBL290175 npy1r_human Human No 4.9 IC50 = 11900 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
632 14 4 4 5.7 C1CC2=C(CN(C1)C(=O)C(CCCNC(=NCCCC3=CC=CC=C3)N)NC(=O)CC4=CC=C(C=C4)C5=CC=CC=C5)C=CC(=C2)O
CHEMBL298983 npy1r_human Human No 7.9 IC50 = 12 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
531 12 2 7 7.0 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OC(C)C)NCC3=CC(=CC(=C3)Cl)NC(=O)OC(C)C)C
CHEMBL2046864 npy1r_human Human No 6.9 IC50 = 120 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
379 5 0 3 5.5 CCOC1=CC=CC(=C1)C2(CCC(CC2)C)N3CCN(CC3)C4=CC=CC=C4
CHEMBL2046864 npy1r_human Human No 6.9 IC50 = 120 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
379 5 0 3 5.5 CCOC1=CC=CC(=C1)C2(CCC(CC2)C)N3CCN(CC3)C4=CC=CC=C4
CHEMBL166606 npy1r_human Human Yes 4.9 IC50 = 12000 Funct
Compound was evaluated for the inhibitory activity against human Neuropeptide Y receptor type 1Compound was evaluated for the inhibitory activity against human Neuropeptide Y receptor type 1
514 6 1 5 5.1 COC1=CC2=C(CCCC(C2)NCC3CCN(CC3)C(=O)CN4C5=C(C=CC(=C5)Cl)SC4=O)C=C1
CHEMBL40475 npy1r_human Human No 4.9 IC50 = 12000 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
567 9 3 3 4.7 C1CC2=CC=CC=C2CN(C1)C(=O)C(CCCN=C(N)N)NC(=O)C(C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl
CHEMBL240221 npy1r_human Human No 4.9 IC50 = 12022 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
480 5 1 4 5.3 CN(C)C(=O)C1=CC(=C2C(=C1)C3=CC=CC=C3N2CC4CCNCC4F)OC5=CC=C(C=C5)Cl
CHEMBL240221 npy1r_human Human No 4.9 IC50 = 12022 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
480 5 1 4 5.3 CN(C)C(=O)C1=CC(=C2C(=C1)C3=CC=CC=C3N2CC4CCNCC4F)OC5=CC=C(C=C5)Cl
CHEMBL1383610 npy1r_human Human Yes 4.9 IC50 = 12050 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
308 5 1 5 4.2 CC1=CC=C(C=C1)COC(=O)C2=NN(N=C2N)C3=CC=CC=C3
CHEMBL1383610 npy1r_human Human Yes 4.9 IC50 = 12050 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
308 5 1 5 4.2 CC1=CC=C(C=C1)COC(=O)C2=NN(N=C2N)C3=CC=CC=C3
CHEMBL1533962 npy1r_human Human Yes 4.9 IC50 = 12260 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
403 8 1 4 3.9 CCC(C)(C(=O)NC1CCCCC1)N(CC2=CC=CO2)C(=O)CC3=CC=CS3
CHEMBL1533962 npy1r_human Human Yes 4.9 IC50 = 12260 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
403 8 1 4 3.9 CCC(C)(C(=O)NC1CCCCC1)N(CC2=CC=CO2)C(=O)CC3=CC=CS3
CHEMBL268409 npy1r_human Human Yes 5.9 IC50 = 1248 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1991 66 31 25 -2.5 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C1=CC=CC=C1)C2=CC=CC=C2)C(=O)N)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(CC4=CNC=N4)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL428992 npy1r_human Human Yes 5.9 IC50 = 1248 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1917 66 32 26 -4.1 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)CNC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL413232 npy1r_human Human Yes 5.9 IC50 = 1270 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1917 66 32 26 -4.1 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NCC(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL1600727 npy1r_human Human Yes 4.9 IC50 = 12770 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
357 5 0 7 4.2 C1=CC=C(C=C1)C2=NC(=CS2)CSC3=NN=C(O3)C4=CC=CS4
CHEMBL1600727 npy1r_human Human Yes 4.9 IC50 = 12770 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
357 5 0 7 4.2 C1=CC=C(C=C1)C2=NC(=CS2)CSC3=NN=C(O3)C4=CC=CS4
CHEMBL2046869 npy1r_human Human No 5.9 IC50 = 1300 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
363 4 0 3 4.7 CC1CC2C(C1)C2(C3=CC=CC=C3OC)N4CCN(CC4)C5=CC=CC=C5
CHEMBL164897 npy1r_human Human No 5.9 IC50 = 1300 Funct
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
477 8 2 4 6.0 C1CC(CCC1CNCC2CCC3=CC=CC=C3C2)CNS(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL51884 npy1r_human Human No 5.9 IC50 = 1300 Funct
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
477 8 2 4 6.0 C1CC(CCC1CNCC2CCC3=CC=CC=C3C2)CNS(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL2046869 npy1r_human Human No 5.9 IC50 = 1300 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
363 4 0 3 4.7 CC1CC2C(C1)C2(C3=CC=CC=C3OC)N4CCN(CC4)C5=CC=CC=C5
CHEMBL562677 npy1r_human Human No 4.9 IC50 = 13000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
374 9 1 7 2.7 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NCCOC)C
CHEMBL562677 npy1r_human Human No 4.9 IC50 = 13000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
374 9 1 7 2.7 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NCCOC)C
CHEMBL1300782 npy1r_human Human Yes 4.9 IC50 = 13170 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
387 5 0 3 3.7 CCC1=NC2=C(C=C(C=C2)Br)C(N1CC(=O)OC)C3=CC=CC=C3
CHEMBL1300782 npy1r_human Human Yes 4.9 IC50 = 13170 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
387 5 0 3 3.7 CCC1=NC2=C(C=C(C=C2)Br)C(N1CC(=O)OC)C3=CC=CC=C3
CHEMBL203433 npy1r_human Human No 5.9 IC50 = 1318.3 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
535 7 0 5 5.2 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CCCN5CCCCC5)OC6=CC=C(C=C6)Cl
CHEMBL203433 npy1r_human Human No 5.9 IC50 = 1318.3 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
535 7 0 5 5.2 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CCCN5CCCCC5)OC6=CC=C(C=C6)Cl
CHEMBL1359694 npy1r_human Human Yes 4.9 IC50 = 13220 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
294 5 0 3 3.8 CCCCOC1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3
CHEMBL1359694 npy1r_human Human Yes 4.9 IC50 = 13220 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
294 5 0 3 3.8 CCCCOC1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3
CHEMBL1412538 npy1r_human Human No 4.9 IC50 = 13260 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
324 2 3 6 2.5 CCC1=CC(=C2C(=CNN2)C3=CC4=C(C=C3)OCO4)C(=O)C=C1O
CHEMBL1412538 npy1r_human Human No 4.9 IC50 = 13260 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
324 2 3 6 2.5 CCC1=CC(=C2C(=CNN2)C3=CC4=C(C=C3)OCO4)C(=O)C=C1O
CHEMBL1351633 npy1r_human Human Yes 4.9 IC50 = 13340 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
350 8 1 3 4.4 CC1=CC(=CC=C1)CSCCNC(=O)COC2=CC=C(C=C2)Cl
CHEMBL1351633 npy1r_human Human Yes 4.9 IC50 = 13340 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
350 8 1 3 4.4 CC1=CC(=CC=C1)CSCCNC(=O)COC2=CC=C(C=C2)Cl
CHEMBL1439255 npy1r_human Human Yes 4.9 IC50 = 13400 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
328 3 0 5 4.5 C1=CC=C2C(=C1)N=C(S2)CN3N=C(N=N3)C4=CC=C(C=C4)Cl
CHEMBL1439255 npy1r_human Human Yes 4.9 IC50 = 13400 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
328 3 0 5 4.5 C1=CC=C2C(=C1)N=C(S2)CN3N=C(N=N3)C4=CC=C(C=C4)Cl
CHEMBL1365319 npy1r_human Human No 4.9 IC50 = 13630 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
246 5 1 3 2.1 CCCCOC1=CC=C(C=C1)C2=NNC(=O)CC2
CHEMBL1365319 npy1r_human Human No 4.9 IC50 = 13630 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
246 5 1 3 2.1 CCCCOC1=CC=C(C=C1)C2=NNC(=O)CC2
CHEMBL1353075 npy1r_human Human Yes 4.9 IC50 = 13680 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
354 9 2 5 2.8 CCCCCCNS(=O)(=O)C1=CC=C(C=C1)NC(=O)C2CCCO2
CHEMBL1353075 npy1r_human Human Yes 4.9 IC50 = 13680 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
354 9 2 5 2.8 CCCCCCNS(=O)(=O)C1=CC=C(C=C1)NC(=O)C2CCCO2
CHEMBL438923 npy1r_human Human Yes 5.9 IC50 = 1390 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1917 66 32 26 -4.1 CC(C)CC(CNC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL239568 npy1r_human Human No 7.9 IC50 = 14 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
602 7 0 5 5.0 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCN(CC5)CC(=O)N(C)C)OC6=CC=C(C=C6)Cl
CHEMBL239568 npy1r_human Human No 7.9 IC50 = 14 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
602 7 0 5 5.0 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCN(CC5)CC(=O)N(C)C)OC6=CC=C(C=C6)Cl
CHEMBL40430 npy1r_human Human No 5.9 IC50 = 1400 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
484 10 4 3 3.3 C1CC2=CC=CC=C2C1NC(=O)C(CCCN=C(N)N)NC(=O)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL162093 npy1r_human Human No 4.9 IC50 = 14000 Funct
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
522 9 2 6 5.2 COC1=CC2=C(CCCC(C2)NCC3CCN(CC3)CCNS(=O)(=O)C4=CC=CC5=CC=CC=C54)C=C1
CHEMBL1391119 npy1r_human Human No 4.8 IC50 = 14700 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
352 8 2 7 2.9 CCCCNC(=O)C1=C(C(=NO1)CSC2=CC=CC=C2F)C(=O)O
CHEMBL1391119 npy1r_human Human No 4.8 IC50 = 14700 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
352 8 2 7 2.9 CCCCNC(=O)C1=C(C(=NO1)CSC2=CC=CC=C2F)C(=O)O
CHEMBL1771260 npy1r_human Human No 7.8 IC50 = 15 Funct
Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayAntagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay
478 8 2 6 4.6 CCOC1=CC(=C(C(=C1)Cl)C2=C3N=C(C=C(N3N=C2C)NCCNC4CCOCC4)C)Cl
CHEMBL1771260 npy1r_human Human No 7.8 IC50 = 15 Funct
Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayAntagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay
478 8 2 6 4.6 CCOC1=CC(=C(C(=C1)Cl)C2=C3N=C(C=C(N3N=C2C)NCCNC4CCOCC4)C)Cl
CHEMBL41673 npy1r_human Human No 6.8 IC50 = 150 Funct
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
472 11 4 3 3.3 CC(C1=CC=CC=C1)NC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL562831 npy1r_human Human No 4.8 IC50 = 15000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
402 10 1 8 3.1 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NCC(=O)OCC)C
CHEMBL560382 npy1r_human Human No 4.8 IC50 = 15000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
376 6 1 8 2.9 CC1=C(SC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC#N)C
CHEMBL159450 npy1r_human Human No 4.8 IC50 = 15000 Funct
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
537 8 2 7 5.1 C1CC(CC2=C(C1)C=CC(=C2)[N+](=O)[O-])NCC3CCN(CC3)CCNS(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL562831 npy1r_human Human No 4.8 IC50 = 15000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
402 10 1 8 3.1 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NCC(=O)OCC)C
CHEMBL560382 npy1r_human Human No 4.8 IC50 = 15000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
376 6 1 8 2.9 CC1=C(SC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC#N)C
CHEMBL214707 npy1r_human Human Yes 5.8 IC50 = 1514 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1990 66 33 26 -3.7 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)CNC(CC3=CC=C(C=C3)O)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CNC=N5)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL412257 npy1r_human Human No 5.8 IC50 = 1567 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1990 66 30 26 -4.7 CCCCC(C(=O)NC(CC(=O)N)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)CNC(CC3=CC=C(C=C3)O)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CNC=N5)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCC)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL378587 npy1r_human Human No 4.8 IC50 = 15848.9 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
522 7 0 5 5.0 C1CCN(CC1)CCCN2C3=CC=CC=C3C4=C2C(CC(C4=O)N5CCOCC5)OC6=CC=C(C=C6)Cl
CHEMBL378587 npy1r_human Human No 4.8 IC50 = 15848.9 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
522 7 0 5 5.0 C1CCN(CC1)CCCN2C3=CC=CC=C3C4=C2C(CC(C4=O)N5CCOCC5)OC6=CC=C(C=C6)Cl
CHEMBL266021 npy1r_human Human No 5.8 IC50 = 1586 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1931 66 29 26 -5.2 CCCCC(C(=O)NC(CC(=O)N)C(=O)NC(CCCC)C(=O)NC(CCC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCC)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL410792 npy1r_human Human No 6.8 IC50 = 159 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
2015 62 29 26 -3.9 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC2=CC=CC=C21)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CNC=N5)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL217692 npy1r_human Human Yes 5.8 IC50 = 1597 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1917 66 32 26 -4.1 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CNC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)C(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL411795 npy1r_human Human No 7.8 IC50 = 16 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
517 5 1 4 5.0 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCNCC5)OC6=CC=C(C=C6)Cl
CHEMBL48950 npy1r_human Human No 7.8 IC50 = 16 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
545 14 2 7 7.4 CCCCOC1=CC(=NC(=C1)NCC2=CC(=CC(=C2)Cl)NC(=O)OC(C)C)CCC3=NC(=C(S3)CC)C
CHEMBL411795 npy1r_human Human No 7.8 IC50 = 16 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
517 5 1 4 5.0 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCNCC5)OC6=CC=C(C=C6)Cl
CHEMBL332347 npy1r_human Human Yes 7.8 IC50 = 16.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
474 11 5 4 2.5 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O
CHEMBL332347 npy1r_human Human Yes 7.8 IC50 = 16.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
474 11 5 4 2.5 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O
CHEMBL564513 npy1r_human Human No 4.8 IC50 = 16000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
344 7 1 6 3.2 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NCC)C
CHEMBL564513 npy1r_human Human No 4.8 IC50 = 16000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
344 7 1 6 3.2 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NCC)C
CHEMBL1504083 npy1r_human Human Yes 4.8 IC50 = 16710 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
376 8 0 4 4.9 CCOC(=O)C1(CCN(CC1)C2CCSCC2)CCCC3=CC=CC=C3
CHEMBL1504083 npy1r_human Human Yes 4.8 IC50 = 16710 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
376 8 0 4 4.9 CCOC(=O)C1(CCN(CC1)C2CCSCC2)CCCC3=CC=CC=C3
CHEMBL1555711 npy1r_human Human No 4.8 IC50 = 16800 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
369 8 2 6 3.4 CCCCNC(=O)C1=C(C(=NO1)CSC2=CC=C(C=C2)Cl)C(=O)O
CHEMBL1555711 npy1r_human Human No 4.8 IC50 = 16800 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
369 8 2 6 3.4 CCCCNC(=O)C1=C(C(=NO1)CSC2=CC=C(C=C2)Cl)C(=O)O
CHEMBL383763 npy1r_human Human No 6.8 IC50 = 169.8 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
539 5 0 6 4.8 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCN(CC5F)C)OC6=CC=C(C=C6)Cl
CHEMBL299598 npy1r_human Human No 7.8 IC50 = 17 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
531 13 2 7 7.1 CCCOC1=CC(=NC(=C1)NCC2=CC(=CC(=C2)Cl)NC(=O)OC(C)C)CCC3=NC(=C(S3)CC)C
CHEMBL52325 npy1r_human Human No 7.8 IC50 = 17 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
557 13 2 7 7.3 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OCC3(CC3)C)NCC4=CC(=CC(=C4)Cl)NC(=O)OC(C)C)C
CHEMBL44246 npy1r_human Human Yes 7.8 IC50 = 17 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
474 11 5 4 2.5 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O
CHEMBL2046861 npy1r_human Human No 6.8 IC50 = 170 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
348 3 1 3 4.4 CC1CC2C(C1)C2(C3=CC=C(C=C3)O)N4CCN(CC4)C5=CC=CC=C5
CHEMBL2046861 npy1r_human Human No 6.8 IC50 = 170 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
348 3 1 3 4.4 CC1CC2C(C1)C2(C3=CC=C(C=C3)O)N4CCN(CC4)C5=CC=CC=C5
CHEMBL41457 npy1r_human Human No 6.8 IC50 = 170 Funct
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
492 11 4 3 3.5 C1=CC=C(C=C1)CNC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
CHEMBL165556 npy1r_human Human No 4.8 IC50 = 17000 Funct
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
552 10 2 7 5.2 COC1=C(C=C2CC(CCCC2=C1)NCC3CCN(CC3)CCNS(=O)(=O)C4=CC=CC5=CC=CC=C54)OC
CHEMBL2046863 npy1r_human Human No 6.8 IC50 = 180 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
350 3 0 3 4.9 CC1CC2C(C1)C2(C3=CC=C(C=C3)F)N4CCN(CC4)C5=CC=CC=C5
CHEMBL2046863 npy1r_human Human No 6.8 IC50 = 180 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
350 3 0 3 4.9 CC1CC2C(C1)C2(C3=CC=C(C=C3)F)N4CCN(CC4)C5=CC=CC=C5
CHEMBL162094 npy1r_human Human No 4.8 IC50 = 18000 Funct
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
506 8 2 5 5.6 CC1=CC2=C(CCCC(C2)NCC3CCN(CC3)CCNS(=O)(=O)C4=CC=CC5=CC=CC=C54)C=C1
CHEMBL411200 npy1r_human Human Yes 6.7 IC50 = 183 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
2004 68 33 26 -3.8 CCCCC(C(=O)NC(CC(=O)N)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCC)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CNC=N5)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCC)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL41981 npy1r_human Human No 6.7 IC50 = 184 Funct
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
488 12 5 4 2.2 C1=CC=C(C=C1)C(CO)NC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL395640 npy1r_human Human No 6.7 IC50 = 186 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
575 6 0 5 6.1 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCN(CC5F)C6CC6)OC7=CC=C(C=C7)Cl
CHEMBL395640 npy1r_human Human No 6.7 IC50 = 186 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
575 6 0 5 6.1 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCN(CC5F)C6CC6)OC7=CC=C(C=C7)Cl
CHEMBL382355 npy1r_human Human No 6.7 IC50 = 186.2 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
525 5 1 6 4.3 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL382355 npy1r_human Human No 6.7 IC50 = 186.2 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
525 5 1 6 4.3 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL240038 npy1r_human Human No 5.7 IC50 = 1862 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
563 8 2 5 6.0 CN1CCCC1CCNC(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL240038 npy1r_human Human No 5.7 IC50 = 1862 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
563 8 2 5 6.0 CN1CCCC1CCNC(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL426314 npy1r_human Human No 5.7 IC50 = 1862.1 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
528 5 1 6 5.6 C1CNCCC1CN2C3=CC=CC=C3C4=C2C(CC(C4=O)N5CCC(CC5)(F)F)OC6=CC=C(C=C6)Cl
CHEMBL426314 npy1r_human Human No 5.7 IC50 = 1862.1 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
528 5 1 6 5.6 C1CNCCC1CN2C3=CC=CC=C3C4=C2C(CC(C4=O)N5CCC(CC5)(F)F)OC6=CC=C(C=C6)Cl
CHEMBL1545205 npy1r_human Human Yes 4.7 IC50 = 18900 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
323 5 1 3 4.4 CC(C)(C)NC(=O)C1=C(C2=CC=CC=C2O1)COC3=CC=CC=C3
CHEMBL1545205 npy1r_human Human Yes 4.7 IC50 = 18900 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
323 5 1 3 4.4 CC(C)(C)NC(=O)C1=C(C2=CC=CC=C2O1)COC3=CC=CC=C3
CHEMBL3198593 npy1r_human Human Yes 4.7 IC50 = 18920 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
378 9 1 6 4.6 CCOC(=O)C(=CNC1=CC(=NN1C2=CC=C(C=C2)Cl)C)C(=O)OCC
CHEMBL3198593 npy1r_human Human Yes 4.7 IC50 = 18920 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
378 9 1 6 4.6 CCOC(=O)C(=CNC1=CC(=NN1C2=CC=C(C=C2)Cl)C)C(=O)OCC
CHEMBL568152 npy1r_human Human No 7.7 IC50 = 19 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
474 10 1 10 3.6 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=NC(=CC=C4)OCCF)C
CHEMBL568152 npy1r_human Human No 7.7 IC50 = 19 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
474 10 1 10 3.6 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=NC(=CC=C4)OCCF)C
CHEMBL288355 npy1r_human Human No 7.7 IC50 = 19 Funct
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
488 11 5 4 2.9 CC(C1=CC=C(C=C1)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL2046858 npy1r_human Human No 6.7 IC50 = 190 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
348 3 1 3 4.1 CC1CC2C(C1)C2(C3=CC(=CC=C3)N)N4CCN(CC4)C5=CC=CC=C5
CHEMBL2046858 npy1r_human Human No 6.7 IC50 = 190 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
348 3 1 3 4.1 CC1CC2C(C1)C2(C3=CC(=CC=C3)N)N4CCN(CC4)C5=CC=CC=C5
CHEMBL167318 npy1r_human Human No 4.7 IC50 = 19000 Funct
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
522 9 2 6 5.2 COC1=CC2=C(CCCC(C2)NCCN3CCC(CC3)CNS(=O)(=O)C4=CC=CC5=CC=CC=C54)C=C1
CHEMBL392583 npy1r_human Human No 5.7 IC50 = 1905 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
558 5 1 5 4.6 C1CNCC(C1CN2C3=CC=CC=C3C4=CC(=CC(=C42)OC5=CC=C(C=C5)Cl)C(=O)N6CCN7C=CN=C7C6)F
CHEMBL392583 npy1r_human Human No 5.7 IC50 = 1905 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
558 5 1 5 4.6 C1CNCC(C1CN2C3=CC=CC=C3C4=CC(=CC(=C42)OC5=CC=C(C=C5)Cl)C(=O)N6CCN7C=CN=C7C6)F
CHEMBL240208 npy1r_human Human No 6.7 IC50 = 191 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
537 8 1 5 5.3 CN(C)CCN(C)C(=O)C1=CC(=C2C(=C1)C3=CC=CC=C3N2CC4CCNCC4F)OC5=CC=C(C=C5)Cl
CHEMBL240208 npy1r_human Human No 6.7 IC50 = 191 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
537 8 1 5 5.3 CN(C)CCN(C)C(=O)C1=CC(=C2C(=C1)C3=CC=CC=C3N2CC4CCNCC4F)OC5=CC=C(C=C5)Cl
CHEMBL1350415 npy1r_human Human Yes 4.7 IC50 = 19100 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
412 6 1 3 5.5 CC(C)OC(=O)C(=CC1=CC2=C(C=C1)N(C3=CC=CC=C32)C)NC(=O)C4=CC=CC=C4
CHEMBL1350415 npy1r_human Human Yes 4.7 IC50 = 19100 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
412 6 1 3 5.5 CC(C)OC(=O)C(=CC1=CC2=C(C=C1)N(C3=CC=CC=C32)C)NC(=O)C4=CC=CC=C4
CHEMBL1538792 npy1r_human Human Yes 5.7 IC50 = 1938 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
441 8 1 6 3.4 CCOC(=O)C1=C(N(C2=C1C(=C(C=C2)O)CN3CCOCC3)C)CSC4=CC=CC=C4
CHEMBL1538792 npy1r_human Human Yes 5.7 IC50 = 1938 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
441 8 1 6 3.4 CCOC(=O)C1=C(N(C2=C1C(=C(C=C2)O)CN3CCOCC3)C)CSC4=CC=CC=C4
CHEMBL366340 npy1r_human Human No 8.7 IC50 = 2 Funct
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
607 11 4 10 3.3 CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC(=CC=C2)NC(=O)NCCNC3CCN(CC3)C4=CC=CC=C4[N+](=O)[O-])C(=O)OC
CHEMBL366340 npy1r_human Human No 8.7 IC50 = 2 Funct
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
607 11 4 10 3.3 CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC(=CC=C2)NC(=O)NCCNC3CCN(CC3)C4=CC=CC=C4[N+](=O)[O-])C(=O)OC
CHEMBL470495 npy1r_human Human No 8.7 IC50 = 2.2 Funct
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
530 13 5 5 3.7 CCC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL438945 npy1r_human Human Yes 8.6 IC50 = 2.6 Funct
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBNDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN
4272 132 59 65 -17.7 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL438411 npy1r_human Human No 8.6 IC50 = 2.7 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
4225 129 58 64 -13.3 CC(C)CC(C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC=N3)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)N5CCCC5C(=O)NC(CCCNC(=N)N)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C7CCCN7C(=O)C(CO)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C8CCCN8C(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C9CCCN9C(=O)C(CCCCN)NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL508974 npy1r_human Human No 8.6 IC50 = 2.8 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 8.6 IC50 = 2.8 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL49177 npy1r_human Human No 7.7 IC50 = 20 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
607 15 2 7 8.5 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OCCCC3=CC=CC=C3)NCC4=CC(=CC(=C4)Cl)NC(=O)OC(C)C)C
CHEMBL41673 npy1r_human Human No 6.7 IC50 = 200 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
472 11 4 3 3.3 CC(C1=CC=CC=C1)NC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL1341841 npy1r_human Human Yes 4.7 IC50 = 20260 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
458 5 1 6 4.3 CC1=C(C=C(C=C1)C2=NN3C(=NN=C3C4=CC=CC=C42)C)S(=O)(=O)NC(C)C5=CC=CC=C5
CHEMBL1341841 npy1r_human Human Yes 4.7 IC50 = 20260 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
458 5 1 6 4.3 CC1=C(C=C(C=C1)C2=NN3C(=NN=C3C4=CC=CC=C42)C)S(=O)(=O)NC(C)C5=CC=CC=C5
CHEMBL1771261 npy1r_human Human No 6.7 IC50 = 207 Funct
Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayAntagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay
492 9 2 6 5.2 CCCOC1=CC(=C(C(=C1)Cl)C2=C3N=C(C=C(N3N=C2C)NCCNC4CCOCC4)C)Cl
CHEMBL1771261 npy1r_human Human No 6.7 IC50 = 207 Funct
Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayAntagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay
492 9 2 6 5.2 CCCOC1=CC(=C(C(=C1)Cl)C2=C3N=C(C=C(N3N=C2C)NCCNC4CCOCC4)C)Cl
CHEMBL582790 npy1r_human Human No 7.7 IC50 = 21 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
430 7 1 9 3.4 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=CN=C(C=C4)F)C
CHEMBL582790 npy1r_human Human No 7.7 IC50 = 21 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
430 7 1 9 3.4 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=CN=C(C=C4)F)C
CHEMBL551197 npy1r_human Human No 4.7 IC50 = 21000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
373 7 1 8 2.7 CCC1=C(N=C(O1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC#N)C
CHEMBL556183 npy1r_human Human No 4.7 IC50 = 21000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
355 7 1 7 2.6 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NCC#N)C
CHEMBL551197 npy1r_human Human No 4.7 IC50 = 21000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
373 7 1 8 2.7 CCC1=C(N=C(O1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC#N)C
CHEMBL556183 npy1r_human Human No 4.7 IC50 = 21000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
355 7 1 7 2.6 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NCC#N)C
CHEMBL296523 npy1r_human Human No 4.7 IC50 = 21000 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
484 10 4 3 3.3 C1CC2=CC=CC=C2C1NC(=O)C(CCCN=C(N)N)NC(=O)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1511420 npy1r_human Human Yes 4.7 IC50 = 21010 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
442 5 2 7 1.9 COC1=C(C=C(C=C1)NC(=O)C2=NNC(=O)C3=CC=CC=C32)S(=O)(=O)N4CCCCC4
CHEMBL1511420 npy1r_human Human Yes 4.7 IC50 = 21010 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
442 5 2 7 1.9 COC1=C(C=C(C=C1)NC(=O)C2=NNC(=O)C3=CC=CC=C32)S(=O)(=O)N4CCCCC4
CHEMBL41166 npy1r_human Human No 4.7 IC50 = 21800 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
458 11 4 3 2.8 C1=CC=C(C=C1)CNC(=O)C(CCCN=C(N)N)NC(=O)CC2=CC=C(C=C2)C3=CC=CC=C3
CHEMBL382836 npy1r_human Human No 7.7 IC50 = 22.4 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
506 5 1 4 5.7 CC1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5)OC6=CC=C(C=C6)Cl
CHEMBL382836 npy1r_human Human No 7.7 IC50 = 22.4 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
506 5 1 4 5.7 CC1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5)OC6=CC=C(C=C6)Cl
CHEMBL2046868 npy1r_human Human No 5.7 IC50 = 2200 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
332 3 0 2 4.8 CC1CC2C(C1)C2(C3=CC=CC=C3)N4CCN(CC4)C5=CC=CC=C5
CHEMBL2046868 npy1r_human Human No 5.7 IC50 = 2200 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
332 3 0 2 4.8 CC1CC2C(C1)C2(C3=CC=CC=C3)N4CCN(CC4)C5=CC=CC=C5
CHEMBL43710 npy1r_human Human No 5.7 IC50 = 2200 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
498 9 3 3 3.4 C1CC2=CC=CC=C2CN(C1)C(=O)C(CCCN=C(N)N)NC(=O)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL560921 npy1r_human Human No 4.7 IC50 = 22000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
369 8 1 7 3.1 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NCCC#N)C
CHEMBL351082 npy1r_human Human No 4.7 IC50 = 22000 Funct
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
508 10 2 6 4.9 COC1=CC2=C(CCCC(C2)CNCC3CN(C3)CCNS(=O)(=O)C4=CC=CC5=CC=CC=C54)C=C1
CHEMBL560921 npy1r_human Human No 4.7 IC50 = 22000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
369 8 1 7 3.1 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NCCC#N)C
CHEMBL290175 npy1r_human Human No 4.7 IC50 = 22000 Funct
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
632 14 4 4 5.7 C1CC2=C(CN(C1)C(=O)C(CCCNC(=NCCCC3=CC=CC=C3)N)NC(=O)CC4=CC=C(C=C4)C5=CC=CC=C5)C=CC(=C2)O
CHEMBL43753 npy1r_human Human No 4.7 IC50 = 22300 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
488 12 5 4 2.2 C1=CC=C(C=C1)C(CO)NC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL1608455 npy1r_human Human Yes 4.6 IC50 = 22650 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
471 9 1 7 2.9 CC1=CC2=C(C=C1)NC(=O)C(=C2)CN(CC3=CC=CC=C3OC)CC4=NN=NN4CC5=CC=CO5
CHEMBL1608455 npy1r_human Human Yes 4.7 IC50 = 22650 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
471 9 1 7 2.9 CC1=CC2=C(C=C1)NC(=O)C(=C2)CN(CC3=CC=CC=C3OC)CC4=NN=NN4CC5=CC=CO5
CHEMBL411637 npy1r_human Human Yes 6.6 IC50 = 233 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
2077 65 34 26 -3.5 CC(C)CC(C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(=O)N)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)N)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL49795 npy1r_human Human No 6.6 IC50 = 234 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
503 11 2 7 6.2 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OC)NCC3=CC(=CC(=C3)Cl)NC(=O)OC(C)C)C
CHEMBL45869 npy1r_human Human No 6.6 IC50 = 237 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
579 13 2 7 7.7 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OCC3=CC=CC=C3)NCC4=CC(=CC(=C4)Cl)NC(=O)OC(C)C)C
CHEMBL379443 npy1r_human Human No 6.6 IC50 = 239.9 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
525 5 1 6 4.3 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL379443 npy1r_human Human No 6.6 IC50 = 239.9 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
525 5 1 6 4.3 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL42686 npy1r_human Human No 5.6 IC50 = 2400 Funct
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
501 12 5 4 2.0 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(C3=CC=CC=C3)C(=O)N
CHEMBL412698 npy1r_human Human Yes 6.6 IC50 = 250 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
2004 65 33 26 -3.9 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CNC=N5)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL433627 npy1r_human Human No 5.6 IC50 = 2500 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
472 11 4 3 3.3 CC(C1=CC=CC=C1)NC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL557648 npy1r_human Human No 4.6 IC50 = 25000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
358 7 1 6 3.7 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NC(C)C)C
CHEMBL557648 npy1r_human Human No 4.6 IC50 = 25000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
358 7 1 6 3.7 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NC(C)C)C
CHEMBL440944 npy1r_human Human No 4.6 IC50 = 25118.9 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
424 3 0 4 4.0 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3C)OC5=CC=C(C=C5)Cl
CHEMBL440944 npy1r_human Human No 4.6 IC50 = 25118.9 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
424 3 0 4 4.0 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3C)OC5=CC=C(C=C5)Cl
CHEMBL430274 npy1r_human Human No 6.6 IC50 = 257 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1921 62 28 26 -5.4 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CSC=C2)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL268351 npy1r_human Human No 4.6 IC50 = 26000 Funct
Compound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cellsCompound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cells
1727 52 25 23 -2.6 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(C1CCCCC1)C(=O)NC(C2CCCCC2)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CNC=N5)NC(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL428915 npy1r_human Human No 6.6 IC50 = 263 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
563 8 2 5 6.0 CCN1CCCC1CNC(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL428915 npy1r_human Human No 6.6 IC50 = 263 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
563 8 2 5 6.0 CCN1CCCC1CNC(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL2397200 npy1r_human Human No 6.6 IC50 = 265 Funct
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
379 5 0 5 3.3 CCOC1=CC=CC(=C1)C2(C3C2CC(C3)C)N4CCN(CC4)C5=NC=CN=C5
CHEMBL3213775 npy1r_human Human Yes 4.6 IC50 = 26730 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
334 6 1 6 2.1 CCCCC(=O)NN=CC1=CC(=C(C=C1)N2CCOCC2)[N+](=O)[O-]
CHEMBL3213775 npy1r_human Human Yes 4.6 IC50 = 26730 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
334 6 1 6 2.1 CCCCC(=O)NN=CC1=CC(=C(C=C1)N2CCOCC2)[N+](=O)[O-]
CHEMBL1319576 npy1r_human Human Yes 4.6 IC50 = 26740 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
286 0 1 3 5.1 C1CCCC2=C(CC1)C(=C3C4=C(CCCC4)SC3=N2)N
CHEMBL1319576 npy1r_human Human Yes 4.6 IC50 = 26740 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
286 0 1 3 5.1 C1CCCC2=C(CC1)C(=C3C4=C(CCCC4)SC3=N2)N
CHEMBL405527 npy1r_human Human Yes 6.6 IC50 = 275 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1991 67 31 25 -2.4 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(CC4=CC=CC=C4)NC(=O)C
CHEMBL412378 npy1r_human Human Yes 6.6 IC50 = 279 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1991 66 31 25 -2.3 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)C3=CC=CC=C3)NC(=O)C(CC4=CNC=N4)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL238517 npy1r_human Human No 7.6 IC50 = 28 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
549 5 0 5 5.5 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCN(CC5F)C)OC6=CC=C(C=C6)Cl
CHEMBL238517 npy1r_human Human No 7.6 IC50 = 28 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
549 5 0 5 5.5 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCN(CC5F)C)OC6=CC=C(C=C6)Cl
CHEMBL540466 npy1r_human Human No 6.6 IC50 = 280 Funct
Antagonist activity at human neuropeptide Y1 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assayAntagonist activity at human neuropeptide Y1 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay
582 8 1 6 5.6 CC1(CC(CCC1C(=O)N2CCC(CC2)(C3=CC=CC=C3)C(=O)N4CCCC4)NC(C5=CC=C(C=C5)OC)C(F)F)C
CHEMBL540466 npy1r_human Human No 6.6 IC50 = 280 Funct
Antagonist activity at human neuropeptide Y1 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assayAntagonist activity at human neuropeptide Y1 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay
582 8 1 6 5.6 CC1(CC(CCC1C(=O)N2CCC(CC2)(C3=CC=CC=C3)C(=O)N4CCCC4)NC(C5=CC=C(C=C5)OC)C(F)F)C
CHEMBL42747 npy1r_human Human No 6.6 IC50 = 280 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
514 9 4 4 3.1 C1CC2=C(CN(C1)C(=O)C(CCCN=C(N)N)NC(=O)C(C3=CC=CC=C3)C4=CC=CC=C4)C=CC(=C2)O
CHEMBL164971 npy1r_human Human No 5.6 IC50 = 2800 Funct
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
536 10 2 6 5.6 COC1=CC2=C(CCCC(C2)CNCCN3CCC(CC3)CNS(=O)(=O)C4=CC=CC5=CC=CC=C54)C=C1
CHEMBL239775 npy1r_human Human No 5.5 IC50 = 2882 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
558 5 2 5 5.0 C1CNCC(C1CN2C3=CC=CC=C3C4=CC(=CC(=C42)OC5=CC=C(C=C5)Cl)C(=O)N6CCC7=C(C6)NC=N7)F
CHEMBL239775 npy1r_human Human No 5.5 IC50 = 2882 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
558 5 2 5 5.0 C1CNCC(C1CN2C3=CC=CC=C3C4=CC(=CC(=C42)OC5=CC=C(C=C5)Cl)C(=O)N6CCC7=C(C6)NC=N7)F
CHEMBL49461 npy1r_human Human No 7.5 IC50 = 29 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
571 12 2 7 8.0 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OC3CCCCC3)NCC4=CC(=CC(=C4)Cl)NC(=O)OC(C)C)C
CHEMBL351508 npy1r_human Human No 4.5 IC50 = 29000 Funct
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
522 9 2 6 5.4 COC1=CC2=C(CCCC(C2)CNC3CCN(CC3)CCNS(=O)(=O)C4=CC=CC5=CC=CC=C54)C=C1
CHEMBL267633 npy1r_human Human No 8.5 IC50 = 3.1 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
4254 131 59 64 -17.0 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL3745739 npy1r_human Human No 8.5 IC50 = 3.1 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
4254 131 59 64 -17.0 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C6CCCN6C(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C8CCCN8C(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
CHEMBL332347 npy1r_human Human Yes 8.4 IC50 = 3.6 Funct
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
474 11 5 4 2.5 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O
CHEMBL332347 npy1r_human Human Yes 8.4 IC50 = 4.0 Funct
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
474 11 5 4 2.5 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O
CHEMBL332347 npy1r_human Human Yes 8.4 IC50 = 4.0 Funct
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
474 11 5 4 2.5 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O
CHEMBL48897 npy1r_human Human No 7.5 IC50 = 30 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
593 14 2 7 8.2 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OCCC3=CC=CC=C3)NCC4=CC(=CC(=C4)Cl)NC(=O)OC(C)C)C
CHEMBL2046870 npy1r_human Human No 6.5 IC50 = 300 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
363 4 0 3 4.7 CC1CC2C(C1)C2(C3=CC(=CC=C3)OC)N4CCN(CC4)C5=CC=CC=C5
CHEMBL2046870 npy1r_human Human No 6.5 IC50 = 300 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
363 4 0 3 4.7 CC1CC2C(C1)C2(C3=CC(=CC=C3)OC)N4CCN(CC4)C5=CC=CC=C5
CHEMBL41686 npy1r_human Human No 5.5 IC50 = 3000 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
518 10 4 3 3.9 C1CC2=CC=CC=C2C1NC(=O)C(CCCN=C(N)N)NC(=O)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl
CHEMBL1562842 npy1r_human Human Yes 4.5 IC50 = 30390 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
413 7 1 4 5.0 CC1=C(OC(=C1)C(C)(C)C)C(=O)N(CC(=O)NC2CCCC2)C3=CC=CC=C3OC
CHEMBL1562842 npy1r_human Human Yes 4.5 IC50 = 30390 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
413 7 1 4 5.0 CC1=C(OC(=C1)C(C)(C)C)C(=O)N(CC(=O)NC2CCCC2)C3=CC=CC=C3OC
CHEMBL1376342 npy1r_human Human Yes 4.5 IC50 = 31850 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
289 4 1 3 5.6 C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=CC=C(C=C3)C(=O)O
CHEMBL1376342 npy1r_human Human Yes 4.5 IC50 = 31850 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
289 4 1 3 5.6 C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=CC=C(C=C3)C(=O)O
CHEMBL571013 npy1r_human Human No 4.5 IC50 = 32000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
330 6 1 6 2.9 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NC)C
CHEMBL571013 npy1r_human Human No 4.5 IC50 = 32000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
330 6 1 6 2.9 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NC)C
CHEMBL1307319 npy1r_human Human Yes 5.5 IC50 = 3205 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
421 6 0 6 4.6 CCN(C1=NN=C(S1)CN2C3=CC=CC=C3N=N2)C(=O)C4=CC=C(C=C4)C(C)(C)C
CHEMBL1307319 npy1r_human Human Yes 5.5 IC50 = 3205 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
421 6 0 6 4.6 CCN(C1=NN=C(S1)CN2C3=CC=CC=C3N=N2)C(=O)C4=CC=C(C=C4)C(C)(C)C
CHEMBL1609697 npy1r_human Human Yes 4.5 IC50 = 32170 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
480 7 1 8 3.2 C1CCC(CC1)NC(=O)C(C2=CC=NC=C2)N(CC3=CC4=C(C=C3)OCO4)C(=O)C5=NSN=C5
CHEMBL1609697 npy1r_human Human Yes 4.5 IC50 = 32170 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
480 7 1 8 3.2 C1CCC(CC1)NC(=O)C(C2=CC=NC=C2)N(CC3=CC4=C(C=C3)OCO4)C(=O)C5=NSN=C5
CHEMBL48947 npy1r_human Human No 7.5 IC50 = 33 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
517 12 2 7 6.6 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OCC)NCC3=CC(=CC(=C3)Cl)NC(=O)OC(C)C)C
CHEMBL424862 npy1r_human Human No 7.5 IC50 = 33.9 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
521 5 0 5 4.7 CN1CCC(CC1)CN2C3=CC=CC=C3C4=C2C(CC(C4=O)N5CCN(CC5)C)OC6=CC=C(C=C6)Cl
CHEMBL424862 npy1r_human Human No 7.5 IC50 = 33.9 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
521 5 0 5 4.7 CN1CCC(CC1)CN2C3=CC=CC=C3C4=C2C(CC(C4=O)N5CCN(CC5)C)OC6=CC=C(C=C6)Cl
CHEMBL206799 npy1r_human Human No 6.5 IC50 = 331.1 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
521 7 1 5 4.7 C1CCN(CC1)CCCN2C3=CC=CC=C3C4=C2C(CC(C4=O)N5CCNCC5)OC6=CC=C(C=C6)Cl
CHEMBL206799 npy1r_human Human No 6.5 IC50 = 331.1 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
521 7 1 5 4.7 C1CCN(CC1)CCCN2C3=CC=CC=C3C4=C2C(CC(C4=O)N5CCNCC5)OC6=CC=C(C=C6)Cl
CHEMBL204583 npy1r_human Human No 5.5 IC50 = 3388.4 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
520 7 0 4 6.2 C1CCN(CC1)CCCN2C3=CC=CC=C3C4=C2C(CC(C4=O)N5CCCCC5)OC6=CC=C(C=C6)Cl
CHEMBL204583 npy1r_human Human No 5.5 IC50 = 3388.4 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
520 7 0 4 6.2 C1CCN(CC1)CCCN2C3=CC=CC=C3C4=C2C(CC(C4=O)N5CCCCC5)OC6=CC=C(C=C6)Cl
CHEMBL1312220 npy1r_human Human Yes 5.5 IC50 = 3391 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
351 5 2 4 4.7 CC1=CC2=CC(=C(C=C2N=C1NCCNC(=O)C3=CC(=CC=C3)F)C)C
CHEMBL1312220 npy1r_human Human Yes 5.5 IC50 = 3391 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
351 5 2 4 4.7 CC1=CC2=CC(=C(C=C2N=C1NCCNC(=O)C3=CC(=CC=C3)F)C)C
CHEMBL48456 npy1r_human Human No 7.5 IC50 = 35 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
559 15 2 7 8.0 CCCCCOC1=CC(=NC(=C1)NCC2=CC(=CC(=C2)Cl)NC(=O)OC(C)C)CCC3=NC(=C(S3)CC)C
CHEMBL266077 npy1r_human Human No 4.5 IC50 = 35000 Funct
Compound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cellsCompound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cells
1675 54 25 23 -3.9 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL165506 npy1r_human Human No 4.5 IC50 = 35000 Funct
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
508 8 2 6 5.0 COC1=CC2=C(CCCC(C2)NC3CCN(CC3)CCNS(=O)(=O)C4=CC=CC5=CC=CC=C54)C=C1
CHEMBL380654 npy1r_human Human No 7.4 IC50 = 37.2 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
537 7 2 6 3.5 C1CNCCC1CN2C3=CC=CC=C3C4=C2C(CC(C4=O)N5CCN(CC5)CCO)OC6=CC=C(C=C6)Cl
CHEMBL380654 npy1r_human Human No 7.4 IC50 = 37.2 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
537 7 2 6 3.5 C1CNCCC1CN2C3=CC=CC=C3C4=C2C(CC(C4=O)N5CCN(CC5)CCO)OC6=CC=C(C=C6)Cl
CHEMBL43628 npy1r_human Human No 5.4 IC50 = 3750 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
459 11 4 4 1.8 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=CC=N3
CHEMBL549699 npy1r_human Human No 4.4 IC50 = 38000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
372 6 1 7 2.0 CC1=C(N(C(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC#N)C)C
CHEMBL549699 npy1r_human Human No 4.4 IC50 = 38000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
372 6 1 7 2.0 CC1=C(N(C(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC#N)C)C
CHEMBL203430 npy1r_human Human No 5.4 IC50 = 3890.5 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
521 5 1 5 3.7 CN1CCN(CC1=O)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5)OC6=CC=C(C=C6)Cl
CHEMBL203430 npy1r_human Human No 5.4 IC50 = 3890.5 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
521 5 1 5 3.7 CN1CCN(CC1=O)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5)OC6=CC=C(C=C6)Cl
CHEMBL414482 npy1r_human Human No 7.4 IC50 = 39 Funct
Compound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cellsCompound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cells
1701 53 25 23 -3.3 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C1CCCCC1)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(CC4=CNC=N4)NC(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL60737 npy1r_human Human No 7.4 IC50 = 39 Funct
The compound was tested for the binding affinity against Neuropeptide Y receptor type 1The compound was tested for the binding affinity against Neuropeptide Y receptor type 1
409 7 0 4 5.7 CCC1CCC(CC1)(C2=CC(=CC=C2)OCOC)N3CCN(CC3)C4=CC=CC=C4
CHEMBL410938 npy1r_human Human Yes 6.4 IC50 = 398 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
2004 65 33 26 -3.9 CC(C)CC(C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CNC=N5)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL188576 npy1r_human Human Yes 8.4 IC50 = 4 Funct
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
631 13 4 11 4.0 CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC(=CC=C2)NC(=NCCNC3CCN(CC3)C4=CC=CC=C4[N+](=O)[O-])NC#N)C(=O)OC
CHEMBL188576 npy1r_human Human Yes 8.4 IC50 = 4 Funct
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
631 13 4 11 4.0 CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC(=CC=C2)NC(=NCCNC3CCN(CC3)C4=CC=CC=C4[N+](=O)[O-])NC#N)C(=O)OC
CHEMBL566663 npy1r_human Human No 8.4 IC50 = 4.3 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
456 9 1 9 2.7 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=NC(=CC=C4)COC)C
CHEMBL566663 npy1r_human Human No 8.4 IC50 = 4.3 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
456 9 1 9 2.7 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=NC(=CC=C4)COC)C
CHEMBL52108 npy1r_human Human No 8.4 IC50 = 4.4 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
573 12 2 8 6.6 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OC3CCOCC3)NCC4=CC(=CC(=C4)Cl)NC(=O)OC(C)C)C
CHEMBL2113710 npy1r_human Human No 8.3 IC50 = 4.7 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
571 15 2 7 8.0 CCC=CCCOC1=CC(=NC(=C1)NCC2=CC(=CC(=C2)Cl)NC(=O)OC(C)C)CCC3=NC(=C(S3)CC)C
CHEMBL437027 npy1r_human Human Yes 8.3 IC50 = 4.7 Funct
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cellsDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells
1620 52 23 21 -4.4 CC(C)CC(C(=O)NCC(=O)NC(CC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CC3=CNC=N3)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C4CCC(=O)N4
CHEMBL1345334 npy1r_human Human Yes 5.4 IC50 = 4021 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
340 5 0 2 5.3 COC1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2C=CC4=CC=CC=C4
CHEMBL1345334 npy1r_human Human Yes 5.4 IC50 = 4021 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
340 5 0 2 5.3 COC1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2C=CC4=CC=CC=C4
CHEMBL1428935 npy1r_human Human Yes 5.4 IC50 = 4079 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
374 4 0 5 4.5 C1=CC(=C(C#N)C#N)N(C=C1)C(=CC2=CC=CO2)C(=O)C3=CC=C(C=C3)Cl
CHEMBL1428935 npy1r_human Human Yes 5.4 IC50 = 4079 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
374 4 0 5 4.5 C1=CC(=C(C#N)C#N)N(C=C1)C(=CC2=CC=CO2)C(=O)C3=CC=C(C=C3)Cl
CHEMBL1353428 npy1r_human Human Yes 5.4 IC50 = 4084 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
378 4 0 3 4.7 CC1=C(C(=CC=C1)N2C=CN=C2SCC(=O)N3CCCC4=CC=CC=C43)C
CHEMBL1353428 npy1r_human Human Yes 5.4 IC50 = 4084 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
378 4 0 3 4.7 CC1=C(C(=CC=C1)N2C=CN=C2SCC(=O)N3CCCC4=CC=CC=C43)C
CHEMBL2397201 npy1r_human Human No 7.4 IC50 = 42 Funct
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
378 5 0 4 4.4 CCOC1=CC=CC(=C1)C2(C3C2CC(C3)C)N4CCN(CC4)C5=CC=CC=N5
CHEMBL1402158 npy1r_human Human Yes 5.4 IC50 = 4261 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
366 5 0 2 5.3 CC1=CC=CC=C1C=CC2=NC3=CC=CC=C3C(=O)N2CCC4=CC=CC=C4
CHEMBL1402158 npy1r_human Human Yes 5.4 IC50 = 4261 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
366 5 0 2 5.3 CC1=CC=CC=C1C=CC2=NC3=CC=CC=C3C(=O)N2CCC4=CC=CC=C4
CHEMBL2397293 npy1r_human Human No 5.4 IC50 = 4270 Funct
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
380 5 0 6 3.5 CCOC1=CC=CC(=C1)C2(C3C2CC(C3)C)N4CCN(CC4)C5=NC=NC=N5
CHEMBL438342 npy1r_human Human No 7.4 IC50 = 43 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
533 5 1 5 4.3 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5=C(CNCC5)F)OC6=CC=C(C=C6)Cl
CHEMBL438342 npy1r_human Human No 7.4 IC50 = 43 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
533 5 1 5 4.3 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5=C(CNCC5)F)OC6=CC=C(C=C6)Cl
CHEMBL560182 npy1r_human Human No 5.4 IC50 = 4300 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
398 7 1 9 4.0 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NCC(F)(F)F)C
CHEMBL560182 npy1r_human Human No 5.4 IC50 = 4300 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
398 7 1 9 4.0 CCC1=C(N=C(O1)CCC2=NC(=CC(=C2)N3CCOCC3)NCC(F)(F)F)C
CHEMBL382204 npy1r_human Human No 6.4 IC50 = 436.5 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
539 5 0 6 4.8 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCN(CC5F)C)OC6=CC=C(C=C6)Cl
CHEMBL382204 npy1r_human Human No 6.4 IC50 = 436.5 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
539 5 0 6 4.8 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCN(CC5F)C)OC6=CC=C(C=C6)Cl
CHEMBL1312713 npy1r_human Human Yes 5.4 IC50 = 4368 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
395 9 1 4 3.9 CCN(CC)CC(COC1=CC2=C(C=C1)N(C(=C2C(=O)C)C)C3=CC=CC=C3)O
CHEMBL1312713 npy1r_human Human Yes 5.4 IC50 = 4368 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
395 9 1 4 3.9 CCN(CC)CC(COC1=CC2=C(C=C1)N(C(=C2C(=O)C)C)C3=CC=CC=C3)O
CHEMBL1502859 npy1r_human Human Yes 5.4 IC50 = 4380 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
375 4 1 5 1.5 C1COCCN1CCNC2=NN3C(=NC4=CC=CC=C4C3=O)C5=CC=CC=C52
CHEMBL2397294 npy1r_human Human No 5.4 IC50 = 4380 Funct
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
379 5 0 5 3.4 CCOC1=CC=CC(=C1)C2(C3C2CC(C3)C)N4CCN(CC4)C5=NN=CC=C5
CHEMBL1502859 npy1r_human Human Yes 5.4 IC50 = 4380 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
375 4 1 5 1.5 C1COCCN1CCNC2=NN3C(=NC4=CC=CC=C4C3=O)C5=CC=CC=C52
CHEMBL415176 npy1r_human Human No 4.4 IC50 = 44000 Funct
Compound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cellsCompound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cells
1701 53 25 23 -3.3 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)NC(C1CCCCC1)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(CC4=CNC=N4)NC(=O)C(CCCN=C(N)N)NC(=O)C
CHEMBL1580409 npy1r_human Human Yes 5.4 IC50 = 4465 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
430 4 1 4 5.0 CN1CCN(CC1)C2=CC=CC=C2NC(=O)C3=CC=C(O3)C4=C(C=C(C=C4)Cl)Cl
CHEMBL1580409 npy1r_human Human Yes 5.4 IC50 = 4465 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
430 4 1 4 5.0 CN1CCN(CC1)C2=CC=CC=C2NC(=O)C3=CC=C(O3)C4=C(C=C(C=C4)Cl)Cl
CHEMBL262221 npy1r_human Human Yes 6.4 IC50 = 447 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1991 66 31 25 -2.5 CC(C)CC(C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(C(C2=CC=CC=C2)C3=CC=CC=C3)NC(=O)C(CC4=CNC=N4)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL417727 npy1r_human Human Yes 5.3 IC50 = 4542 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
223 0 1 3 1.8 C1=CC=C2C(=C1)C3=C(C=C(C=C3)N)C(=O)C2=O
CHEMBL417727 npy1r_human Human Yes 5.3 IC50 = 4542 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
223 0 1 3 1.8 C1=CC=C2C(=C1)C3=C(C=C(C=C3)N)C(=O)C2=O
CHEMBL1531745 npy1r_human Human Yes 5.3 IC50 = 4576 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
438 8 1 5 5.0 COC1=CC=CC(=C1)C2=NC(=C(C=C2)C#N)SCC(=O)NCCC3=CC=C(C=C3)Cl
CHEMBL1531745 npy1r_human Human Yes 5.3 IC50 = 4576 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
438 8 1 5 5.0 COC1=CC=CC(=C1)C2=NC(=C(C=C2)C#N)SCC(=O)NCCC3=CC=C(C=C3)Cl
CHEMBL2046860 npy1r_human Human No 6.3 IC50 = 460 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
347 3 0 2 5.1 CC1CC2C(C1)C2(C3=CC=C(C=C3)C)N4CCN(CC4)C5=CC=CC=C5
CHEMBL2046860 npy1r_human Human No 6.3 IC50 = 460 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
347 3 0 2 5.1 CC1CC2C(C1)C2(C3=CC=C(C=C3)C)N4CCN(CC4)C5=CC=CC=C5
CHEMBL42686 npy1r_human Human No 5.3 IC50 = 4600 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
501 12 5 4 2.0 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(C3=CC=CC=C3)C(=O)N
CHEMBL238736 npy1r_human Human No 6.3 IC50 = 467 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
549 6 1 5 5.5 CN(C)C1CCN(C1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL238736 npy1r_human Human No 6.3 IC50 = 467 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
549 6 1 5 5.5 CN(C)C1CCN(C1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL2111764 npy1r_human Human Yes 7.3 IC50 = 47.9 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
2004 65 33 26 -3.9 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CNC=N5)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL427594 npy1r_human Human Yes 7.3 IC50 = 48.9 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
2007 67 32 26 -2.7 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C
CHEMBL439506 npy1r_human Human No 7.3 IC50 = 49.0 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
507 5 1 5 4.2 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5)OC6=CC=C(C=C6)Cl
CHEMBL439506 npy1r_human Human No 7.3 IC50 = 49.0 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
507 5 1 5 4.2 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5)OC6=CC=C(C=C6)Cl
CHEMBL1419096 npy1r_human Human Yes 5.3 IC50 = 4826 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
392 6 2 8 2.0 COC(=O)C1=CC=CC=C1NC(=O)CN2C3=CC=CC=C3N=C2C4=NON=C4N
CHEMBL1419096 npy1r_human Human Yes 5.3 IC50 = 4826 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
392 6 2 8 2.0 COC(=O)C1=CC=CC=C1NC(=O)CN2C3=CC=CC=C3N=C2C4=NON=C4N
CHEMBL1471779 npy1r_human Human Yes 5.3 IC50 = 4838 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
501 6 0 7 4.9 CC1=C(C2=C(O1)C=CC(=C2)N(C(=O)C3=CC=NC=C3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4)C(=O)OC
CHEMBL1471779 npy1r_human Human Yes 5.3 IC50 = 4838 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
501 6 0 7 4.9 CC1=C(C2=C(O1)C=CC(=C2)N(C(=O)C3=CC=NC=C3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4)C(=O)OC
CHEMBL584908 npy1r_human Human No 8.3 IC50 = 5.2 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
430 7 1 9 3.4 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=CC(=NC=C4)F)C
CHEMBL584908 npy1r_human Human No 8.3 IC50 = 5.2 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
430 7 1 9 3.4 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=CC(=NC=C4)F)C
CHEMBL51284 npy1r_human Human No 8.3 IC50 = 5.5 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
559 14 2 7 8.0 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OC(CC)CC)NCC3=CC(=CC(=C3)Cl)NC(=O)OC(C)C)C
CHEMBL44246 npy1r_human Human Yes 8.2 IC50 = 5.9 Funct
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
474 11 5 4 2.5 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O
CHEMBL239773 npy1r_human Human No 7.3 IC50 = 50 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
545 7 0 4 5.9 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CCCN5CCCCC5)OC6=CC=C(C=C6)Cl
CHEMBL398782 npy1r_human Human No 7.3 IC50 = 50 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
523 8 2 5 5.1 CN(C)CCNC(=O)C1=CC(=C2C(=C1)C3=CC=CC=C3N2CC4CCNCC4F)OC5=CC=C(C=C5)Cl
CHEMBL239773 npy1r_human Human No 7.3 IC50 = 50 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
545 7 0 4 5.9 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CCCN5CCCCC5)OC6=CC=C(C=C6)Cl
CHEMBL398782 npy1r_human Human No 7.3 IC50 = 50 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
523 8 2 5 5.1 CN(C)CCNC(=O)C1=CC(=C2C(=C1)C3=CC=CC=C3N2CC4CCNCC4F)OC5=CC=C(C=C5)Cl
CHEMBL1499276 npy1r_human Human Yes 5.3 IC50 = 5010 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
396 3 1 4 4.8 CC1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=C2)C(=O)NC4=CC5=C(C=C4)OCCO5
CHEMBL1499276 npy1r_human Human Yes 5.3 IC50 = 5010 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
396 3 1 4 4.8 CC1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=C2)C(=O)NC4=CC5=C(C=C4)OCCO5
CHEMBL3211272 npy1r_human Human Yes 5.3 IC50 = 5022 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
318 5 2 2 4.2 C1=CC=C(C=C1)CCNC(=S)NN=CC2=CC=CC=C2Cl
CHEMBL3211272 npy1r_human Human Yes 5.3 IC50 = 5022 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
318 5 2 2 4.2 C1=CC=C(C=C1)CCNC(=S)NN=CC2=CC=CC=C2Cl
CHEMBL2397296 npy1r_human Human No 5.3 IC50 = 5032 Funct
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
379 5 0 5 3.4 CCOC1=CC=CC(=C1)C2(C3C2CC(C3)C)N4CCN(CC4)C5=CN=CN=C5
CHEMBL240404 npy1r_human Human No 7.3 IC50 = 51 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
535 5 1 5 5.1 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL240404 npy1r_human Human No 7.3 IC50 = 51 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
535 5 1 5 5.1 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL1468302 npy1r_human Human Yes 5.3 IC50 = 5100 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
415 5 1 4 6.0 C1=CC=C2C(=C1)C=CC=C2CC3=NN=C(N3N)SCC4=C(C=CC=C4Cl)Cl
CHEMBL1468302 npy1r_human Human Yes 5.3 IC50 = 5100 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
415 5 1 4 6.0 C1=CC=C2C(=C1)C=CC=C2CC3=NN=C(N3N)SCC4=C(C=CC=C4Cl)Cl
CHEMBL42861 npy1r_human Human No 4.3 IC50 = 51000 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
574 10 3 3 4.9 C1CC2=CC=CC=C2CN(C1)C(=O)C(CCCN=C(N)N)NC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL1585445 npy1r_human Human Yes 5.3 IC50 = 5137 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
331 5 0 5 4.3 CC1=C(C=CC(=C1)OCC2=NC(=NO2)C3=CC=C(C=C3)OC)Cl
CHEMBL1585445 npy1r_human Human Yes 5.3 IC50 = 5137 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
331 5 0 5 4.3 CC1=C(C=CC(=C1)OCC2=NC(=NO2)C3=CC=C(C=C3)OC)Cl
CHEMBL1559259 npy1r_human Human Yes 5.3 IC50 = 5210 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
392 6 0 6 4.2 COC(=O)C1=CC=C(O1)CSC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4
CHEMBL1559259 npy1r_human Human Yes 5.3 IC50 = 5210 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
392 6 0 6 4.2 COC(=O)C1=CC=C(O1)CSC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4
CHEMBL1427745 npy1r_human Human Yes 5.3 IC50 = 5265 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
405 7 1 4 4.6 CCC(=C1C(=O)N(C(=O)N(C1=O)C)C)NCCC(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL1427745 npy1r_human Human Yes 5.3 IC50 = 5265 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
405 7 1 4 4.6 CCC(=C1C(=O)N(C(=O)N(C1=O)C)C)NCCC(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL1522356 npy1r_human Human Yes 5.3 IC50 = 5266 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
373 3 0 3 5.4 C1CC2=CC(=NN=C2C3=CC=CC=C31)SCC4=CC(=C(C=C4)Cl)Cl
CHEMBL1522356 npy1r_human Human Yes 5.3 IC50 = 5266 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
373 3 0 3 5.4 C1CC2=CC(=NN=C2C3=CC=CC=C31)SCC4=CC(=C(C=C4)Cl)Cl
CHEMBL392787 npy1r_human Human No 7.3 IC50 = 53 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
535 5 1 5 5.1 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL392787 npy1r_human Human No 7.3 IC50 = 53 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
535 5 1 5 5.1 CN1CCN(CC1)C(=O)C2=CC(=C3C(=C2)C4=CC=CC=C4N3CC5CCNCC5F)OC6=CC=C(C=C6)Cl
CHEMBL41686 npy1r_human Human No 5.3 IC50 = 5300 Funct
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
518 10 4 3 3.9 C1CC2=CC=CC=C2C1NC(=O)C(CCCN=C(N)N)NC(=O)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl
CHEMBL1312703 npy1r_human Human Yes 5.3 IC50 = 5306 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
376 6 1 4 4.9 CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=C(C=C(C(=C2)OC)C(=O)OC)Cl
CHEMBL1312703 npy1r_human Human Yes 5.3 IC50 = 5306 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
376 6 1 4 4.9 CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=C(C=C(C(=C2)OC)C(=O)OC)Cl
CHEMBL3195229 npy1r_human Human Yes 5.3 IC50 = 5335 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
399 6 1 4 4.4 C1=CC=C(C(=C1)C(=O)NN=CC2=CC=CO2)OCC3=CC=C(C=C3)Br
CHEMBL3195229 npy1r_human Human Yes 5.3 IC50 = 5335 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
399 6 1 4 4.4 C1=CC=C(C(=C1)C(=O)NN=CC2=CC=CO2)OCC3=CC=C(C=C3)Br
CHEMBL2397291 npy1r_human Human No 7.3 IC50 = 54 Funct
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
379 5 0 5 3.7 CCOC1=CC=CC(=C1)C2(C3C2CC(C3)C)N4CCN(CC4)C5=NC=CC=N5
CHEMBL1537995 npy1r_human Human Yes 5.3 IC50 = 5404 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
360 5 0 4 5.9 CC1=C(SC(=N1)C2=CC=CC=C2)C(=O)CSC3=CC=C(C=C3)Cl
CHEMBL1537995 npy1r_human Human Yes 5.3 IC50 = 5404 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
360 5 0 4 5.9 CC1=C(SC(=N1)C2=CC=CC=C2)C(=O)CSC3=CC=C(C=C3)Cl
CHEMBL1568243 npy1r_human Human Yes 5.3 IC50 = 5470 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
259 3 0 2 3.9 C1=CC=C2C(=C1)C=CC=C2C=CC(=O)C3=CC=NC=C3
CHEMBL1568243 npy1r_human Human Yes 5.3 IC50 = 5470 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
259 3 0 2 3.9 C1=CC=C2C(=C1)C=CC=C2C=CC(=O)C3=CC=NC=C3
CHEMBL422583 npy1r_human Human No 7.3 IC50 = 55 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
559 13 2 7 7.9 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OCC(C)(C)C)NCC3=CC(=CC(=C3)Cl)NC(=O)OC(C)C)C
CHEMBL2046862 npy1r_human Human No 6.3 IC50 = 550 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
363 4 0 3 4.7 CC1CC2C(C1)C2(C3=CC=C(C=C3)OC)N4CCN(CC4)C5=CC=CC=C5
CHEMBL2046862 npy1r_human Human No 6.3 IC50 = 550 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
363 4 0 3 4.7 CC1CC2C(C1)C2(C3=CC=C(C=C3)OC)N4CCN(CC4)C5=CC=CC=C5
CHEMBL1431004 npy1r_human Human Yes 5.3 IC50 = 5537 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
389 8 0 7 4.9 CCOC1=NC(=NC(=N1)N(C)C)SCCOC2=C(C=C(C=C2)Cl)Cl
CHEMBL1431004 npy1r_human Human Yes 5.3 IC50 = 5537 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
389 8 0 7 4.9 CCOC1=NC(=NC(=N1)N(C)C)SCCOC2=C(C=C(C=C2)Cl)Cl
CHEMBL1487131 npy1r_human Human Yes 5.3 IC50 = 5680 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
335 4 0 5 5.0 CC(C)C1=CC=C(C=C1)C2=NN(N=N2)CC3=NC4=CC=CC=C4S3
CHEMBL1487131 npy1r_human Human Yes 5.3 IC50 = 5680 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
335 4 0 5 5.0 CC(C)C1=CC=C(C=C1)C2=NN(N=N2)CC3=NC4=CC=CC=C4S3
CHEMBL1427504 npy1r_human Human Yes 5.3 IC50 = 5687 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
402 6 1 2 5.5 C1=CC=C(C=C1)C2=CC=CC=C2NC(=O)CSCC3=C(C=CC=C3Cl)Cl
CHEMBL1423799 npy1r_human Human Yes 5.3 IC50 = 5687 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
372 4 0 4 4.8 C1=CC(=CN=C1)C2=NC(=C(C=C2)C#N)SCC3=CC(=C(C=C3)Cl)Cl
CHEMBL1427504 npy1r_human Human Yes 5.3 IC50 = 5687 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
402 6 1 2 5.5 C1=CC=C(C=C1)C2=CC=CC=C2NC(=O)CSCC3=C(C=CC=C3Cl)Cl
CHEMBL1423799 npy1r_human Human Yes 5.3 IC50 = 5687 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
372 4 0 4 4.8 C1=CC(=CN=C1)C2=NC(=C(C=C2)C#N)SCC3=CC(=C(C=C3)Cl)Cl
CHEMBL1453672 npy1r_human Human Yes 5.2 IC50 = 5724 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
407 7 1 3 5.9 C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)OCC(=O)NC3=CC=CC=C3C4=CC=CC=C4
CHEMBL1453672 npy1r_human Human Yes 5.2 IC50 = 5724 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
407 7 1 3 5.9 C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)OCC(=O)NC3=CC=CC=C3C4=CC=CC=C4
CHEMBL1493500 npy1r_human Human Yes 5.2 IC50 = 5769 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
445 8 1 5 6.4 CCC1=C(C(=CC=C1)CC)NC(=O)COC(=O)C2=CC=CC=C2C3=NC4=CC=CC=C4S3
CHEMBL1493500 npy1r_human Human Yes 5.2 IC50 = 5769 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
445 8 1 5 6.4 CCC1=C(C(=CC=C1)CC)NC(=O)COC(=O)C2=CC=CC=C2C3=NC4=CC=CC=C4S3
CHEMBL1426896 npy1r_human Human Yes 5.2 IC50 = 5853 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
426 7 0 7 4.3 CC=C(C)C(=O)OC1C(OC2=C1C3=C(C=C2)C=CC(=O)O3)C(C)(C)OC(=O)C(=CC)C
CHEMBL1426896 npy1r_human Human Yes 5.2 IC50 = 5853 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
426 7 0 7 4.3 CC=C(C)C(=O)OC1C(OC2=C1C3=C(C=C2)C=CC(=O)O3)C(C)(C)OC(=O)C(=CC)C
CHEMBL51290 npy1r_human Human No 8.2 IC50 = 6.5 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
608 15 2 8 7.4 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OCCCC3=CN=CC=C3)NCC4=CC(=CC(=C4)Cl)NC(=O)OC(C)C)C
CHEMBL288355 npy1r_human Human No 7.2 IC50 = 60 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
488 11 5 4 2.9 CC(C1=CC=C(C=C1)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL18016 npy1r_human Human No 4.2 IC50 = 60000 Funct
Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1
419 4 1 7 2.9 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCC(CC3)N4CC5=CC=CC=C5C4=O)N)OC
CHEMBL1335124 npy1r_human Human Yes 5.2 IC50 = 6127 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
392 7 1 3 5.4 C1=CC=C(C=C1)C2=CC=CC=C2NC(=O)COC(=O)C=CC3=CC=C(C=C3)Cl
CHEMBL1335124 npy1r_human Human Yes 5.2 IC50 = 6127 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
392 7 1 3 5.4 C1=CC=C(C=C1)C2=CC=CC=C2NC(=O)COC(=O)C=CC3=CC=C(C=C3)Cl
CHEMBL2046867 npy1r_human Human No 7.2 IC50 = 62 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
377 5 0 3 5.1 CCOC1=CC=CC(=C1)C2(C3C2CC(C3)C)N4CCN(CC4)C5=CC=CC=C5
CHEMBL2397299 npy1r_human Human No 7.2 IC50 = 62 Funct
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
377 5 0 3 5.1 CCOC1=CC=CC(=C1)C2(C3C2CC(C3)C)N4CCN(CC4)C5=CC=CC=C5
CHEMBL2046867 npy1r_human Human No 7.2 IC50 = 62 Funct
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
377 5 0 3 5.1 CCOC1=CC=CC(=C1)C2(C3C2CC(C3)C)N4CCN(CC4)C5=CC=CC=C5
CHEMBL51422 npy1r_human Human No 7.2 IC50 = 63 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
573 16 2 7 8.5 CCCCCCOC1=CC(=NC(=C1)NCC2=CC(=CC(=C2)Cl)NC(=O)OC(C)C)CCC3=NC(=C(S3)CC)C
CHEMBL1379143 npy1r_human Human Yes 5.2 IC50 = 6324 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
423 6 2 3 3.8 CC1=CC(=CC=C1)NC(=S)N(CCN(C)C)CC2=CC3=CC(=CC(=C3NC2=O)C)C
CHEMBL1379143 npy1r_human Human Yes 5.2 IC50 = 6324 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
423 6 2 3 3.8 CC1=CC(=CC=C1)NC(=S)N(CCN(C)C)CC2=CC3=CC(=CC(=C3NC2=O)C)C
CHEMBL1393538 npy1r_human Human Yes 5.2 IC50 = 6433 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
459 8 1 4 4.5 CC1=C(C(=CC=C1)N2CCN(CC2)CCNC(=O)CN3C=CC=C3C(=O)C4=CC=CC=C4C)C
CHEMBL1393538 npy1r_human Human Yes 5.2 IC50 = 6433 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
459 8 1 4 4.5 CC1=C(C(=CC=C1)N2CCN(CC2)CCNC(=O)CN3C=CC=C3C(=O)C4=CC=CC=C4C)C
CHEMBL206671 npy1r_human Human No 6.2 IC50 = 645.7 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
534 7 0 4 6.6 CC1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CCCN5CCCCC5)OC6=CC=C(C=C6)Cl
CHEMBL206671 npy1r_human Human No 6.2 IC50 = 645.7 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
534 7 0 4 6.6 CC1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CCCN5CCCCC5)OC6=CC=C(C=C6)Cl
CHEMBL3190644 npy1r_human Human No 5.2 IC50 = 6459 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
295 4 1 4 4.5 CC(C)COC(=O)C1=CC=CC2=C1C3=CC=CC=C3C2=NO
CHEMBL3190644 npy1r_human Human No 5.2 IC50 = 6459 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
295 4 1 4 4.5 CC(C)COC(=O)C1=CC=CC2=C1C3=CC=CC=C3C2=NO
CHEMBL1327690 npy1r_human Human Yes 5.2 IC50 = 6664 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
332 4 0 5 4.2 C1CCCN(CC1)C2=C(N=C(O2)COC3=CC=C(C=C3)Cl)C#N
CHEMBL1327690 npy1r_human Human Yes 5.2 IC50 = 6664 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
332 4 0 5 4.2 C1CCCN(CC1)C2=C(N=C(O2)COC3=CC=C(C=C3)Cl)C#N
CHEMBL1336318 npy1r_human Human Yes 5.2 IC50 = 6687 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
336 4 0 2 5.0 C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)C(=O)C4=CC=CO4
CHEMBL1336318 npy1r_human Human Yes 5.2 IC50 = 6687 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
336 4 0 2 5.0 C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)C(=O)C4=CC=CO4
CHEMBL42747 npy1r_human Human No 6.2 IC50 = 670 Funct
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
514 9 4 4 3.1 C1CC2=C(CN(C1)C(=O)C(CCCN=C(N)N)NC(=O)C(C3=CC=CC=C3)C4=CC=CC=C4)C=CC(=C2)O
CHEMBL425095 npy1r_human Human No 6.2 IC50 = 674 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1849 63 30 24 -3.7 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL1407634 npy1r_human Human Yes 5.2 IC50 = 6748 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
447 4 0 8 5.4 CC1=C(C(=O)C=CN1C2=C(C=C(C=N2)C(F)(F)F)Cl)OCC3=C(C=CC=C3Cl)F
CHEMBL1407634 npy1r_human Human Yes 5.2 IC50 = 6748 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
447 4 0 8 5.4 CC1=C(C(=O)C=CN1C2=C(C=C(C=N2)C(F)(F)F)Cl)OCC3=C(C=CC=C3Cl)F
CHEMBL1446166 npy1r_human Human Yes 5.2 IC50 = 6943 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
315 3 1 3 4.4 C1=CC=C(C=C1)C2=NC(=CS2)C(=O)NC3=CC=C(C=C3)Cl
CHEMBL1446166 npy1r_human Human Yes 5.2 IC50 = 6943 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
315 3 1 3 4.4 C1=CC=C(C=C1)C2=NC(=CS2)C(=O)NC3=CC=C(C=C3)Cl
CHEMBL1574689 npy1r_human Human Yes 5.2 IC50 = 6952 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
390 5 0 7 3.8 CN1C(=O)C2=C(N=C1SCC3=CC=C(O3)C(=O)OC)SC4=C2CCCC4
CHEMBL1574689 npy1r_human Human Yes 5.2 IC50 = 6952 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
390 5 0 7 3.8 CN1C(=O)C2=C(N=C1SCC3=CC=C(O3)C(=O)OC)SC4=C2CCCC4
CHEMBL1610409 npy1r_human Human Yes 5.2 IC50 = 6959 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
329 5 0 4 5.0 C1=CC=C(C=C1)C=CC2=NN=C(O2)SCC3=CC=CC=C3Cl
CHEMBL1610409 npy1r_human Human Yes 5.2 IC50 = 6959 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
329 5 0 4 5.0 C1=CC=C(C=C1)C=CC2=NN=C(O2)SCC3=CC=CC=C3Cl
CHEMBL1771259 npy1r_human Human Yes 8.2 IC50 = 7 Funct
Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayAntagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay
464 7 2 6 4.3 CC1=NC2=C(C(=NN2C(=C1)NCCNC3CCOCC3)C)C4=C(C=C(C=C4Cl)OC)Cl
CHEMBL1771259 npy1r_human Human Yes 8.2 IC50 = 7 Funct
Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayAntagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay
464 7 2 6 4.3 CC1=NC2=C(C(=NN2C(=C1)NCCNC3CCOCC3)C)C4=C(C=C(C=C4Cl)OC)Cl
CHEMBL567708 npy1r_human Human No 8.1 IC50 = 7.7 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
430 7 1 9 3.4 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=C(N=CC=C4)F)C
CHEMBL567708 npy1r_human Human No 8.1 IC50 = 7.7 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
430 7 1 9 3.4 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC4=C(N=CC=C4)F)C
CHEMBL563011 npy1r_human Human No 4.2 IC50 = 70000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
359 6 1 8 2.3 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC#N)C
CHEMBL563011 npy1r_human Human No 4.2 IC50 = 70000 Funct
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
359 6 1 8 2.3 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCOCC3)NCC#N)C
CHEMBL3208997 npy1r_human Human Yes 5.2 IC50 = 7083 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
322 6 0 5 3.0 CC1=CC=C(C=C1)COC2=C(C=C(C=C2)C=NN3C=NN=C3)OC
CHEMBL3208997 npy1r_human Human Yes 5.2 IC50 = 7083 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
322 6 0 5 3.0 CC1=CC=C(C=C1)COC2=C(C=C(C=C2)C=NN3C=NN=C3)OC
CHEMBL1990096 npy1r_human Human Yes 5.2 IC50 = 7084 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
325 6 0 4 5.1 CC1=C(C=C(C=C1)C(=NOC(=O)C2=CC=C(C=C2)OC(C)C)C)C
CHEMBL1990096 npy1r_human Human Yes 5.2 IC50 = 7084 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
325 6 0 4 5.1 CC1=C(C=C(C=C1)C(=NOC(=O)C2=CC=C(C=C2)OC(C)C)C)C
CHEMBL1328939 npy1r_human Human Yes 5.2 IC50 = 7100 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
434 3 1 8 5.7 CC1=C(SC2=NC(=NC(=C12)N3CCCCC3)C)C(=O)NC4=CC=CC=C4C(F)(F)F
CHEMBL1328939 npy1r_human Human Yes 5.2 IC50 = 7100 Funct
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
434 3 1 8 5.7 CC1=C(SC2=NC(=NC(=C12)N3CCCCC3)C)C(=O)NC4=CC=CC=C4C(F)(F)F
CHEMBL1545971 npy1r_human Human Yes 5.2 IC50 = 7125 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
384 3 1 5 4.9 CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3=C(C4=C(S3)CCC4)C#N
CHEMBL1545971 npy1r_human Human Yes 5.2 IC50 = 7125 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
384 3 1 5 4.9 CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3=C(C4=C(S3)CCC4)C#N
CHEMBL1480648 npy1r_human Human Yes 5.1 IC50 = 7156 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
415 4 1 6 3.5 COC1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3C(=N2)C(=O)NC4=CC5=C(C=C4)OCO5
CHEMBL1480648 npy1r_human Human Yes 5.2 IC50 = 7156 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
415 4 1 6 3.5 COC1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3C(=N2)C(=O)NC4=CC5=C(C=C4)OCO5
CHEMBL48493 npy1r_human Human No 7.1 IC50 = 72 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
587 17 2 7 9.1 CCCCCCCOC1=CC(=NC(=C1)NCC2=CC(=CC(=C2)Cl)NC(=O)OC(C)C)CCC3=NC(=C(S3)CC)C
CHEMBL1308461 npy1r_human Human Yes 5.1 IC50 = 7229 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
281 1 0 4 4.2 CC1CCN(CC1)C2=NC(=NC3=C2OC4=CC=CC=C43)C
CHEMBL1308461 npy1r_human Human Yes 5.1 IC50 = 7229 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
281 1 0 4 4.2 CC1CCN(CC1)C2=NC(=NC3=C2OC4=CC=CC=C43)C
CHEMBL206112 npy1r_human Human No 5.1 IC50 = 7244.4 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
437 6 0 3 5.2 C1CCN(CC1)CCCN2C3=CC=CC=C3C4=C2C(CCC4=O)OC5=CC=C(C=C5)Cl
CHEMBL206112 npy1r_human Human No 5.1 IC50 = 7244.4 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
437 6 0 3 5.2 C1CCN(CC1)CCCN2C3=CC=CC=C3C4=C2C(CCC4=O)OC5=CC=C(C=C5)Cl
CHEMBL564979 npy1r_human Human Yes 5.1 IC50 = 7273 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
395 6 1 4 5.1 CC1=CC=C(O1)CCC(=O)NC2=NC=C(S2)CC3=C(C=CC(=C3)Cl)Cl
CHEMBL564979 npy1r_human Human Yes 5.1 IC50 = 7273 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
395 6 1 4 5.1 CC1=CC=C(O1)CCC(=O)NC2=NC=C(S2)CC3=C(C=CC(=C3)Cl)Cl
CHEMBL1386511 npy1r_human Human Yes 5.1 IC50 = 7326 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
313 6 0 4 3.8 CN(C)CCCSC1=NC(=NC2=C1CCC2)C3=CC=CC=C3
CHEMBL1386511 npy1r_human Human Yes 5.1 IC50 = 7326 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
313 6 0 4 3.8 CN(C)CCCSC1=NC(=NC2=C1CCC2)C3=CC=CC=C3
CHEMBL428292 npy1r_human Human Yes 6.1 IC50 = 735 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1917 66 32 26 -4.1 CC(C)CC(CNC(CCCNC(=N)N)C(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)N)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL1383592 npy1r_human Human Yes 5.1 IC50 = 7387 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
347 5 2 3 3.8 CC1=CC(=C(C=C1)NC(=O)C(=O)NCCOC2=CC=C(C=C2)Cl)C
CHEMBL1383592 npy1r_human Human Yes 5.1 IC50 = 7387 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
347 5 2 3 3.8 CC1=CC(=C(C=C1)NC(=O)C(=O)NCCOC2=CC=C(C=C2)Cl)C
CHEMBL2314835 npy1r_human Human No 7.1 IC50 = 74 Funct
Binding affinity to Y1 receptor in human SK-N-MC cellsBinding affinity to Y1 receptor in human SK-N-MC cells
3241 109 40 49 -11.5 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)N1CCCC1C(=O)NC(CCCCNC(=O)COCCOCCNC(=O)C(CCCCNC(=O)COCC(=O)NCCOCCOCC(=O)NCC(=O)NC2=CC=C(C=C2)C(=O)NC(CCC(=O)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CC5=CN=CN5)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)N)NC(=O)CN6CCN(CCN(CCN(CC6)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)N
CHEMBL1311570 npy1r_human Human Yes 5.1 IC50 = 7444 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
427 6 0 5 3.8 C1=CC=NC(=C1)C2=NN=C(N2CC3=CC=CO3)SCC4=CC=C(C=C4)Br
CHEMBL1311570 npy1r_human Human Yes 5.1 IC50 = 7444 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
427 6 0 5 3.8 C1=CC=NC(=C1)C2=NN=C(N2CC3=CC=CO3)SCC4=CC=C(C=C4)Br
CHEMBL43523 npy1r_human Human No 5.1 IC50 = 7500 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
501 12 5 4 2.0 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(C3=CC=CC=C3)C(=O)N
CHEMBL428320 npy1r_human Human Yes 7.1 IC50 = 77.0 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1954 65 32 25 -3.8 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CNC=N4)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL42625 npy1r_human Human No 4.1 IC50 = 76000 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
498 9 3 3 3.4 C1CC2=CC=CC=C2CN(C1)C(=O)C(CCCN=C(N)N)NC(=O)CC3=CC=C(C=C3)C4=CC=CC=C4
CHEMBL438935 npy1r_human Human Yes 6.1 IC50 = 762 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
2003 65 32 25 -1.1 CC(C)CC(C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC5=CNC=N5)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL1539256 npy1r_human Human Yes 5.1 IC50 = 7623 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
497 10 1 7 3.9 COC1=CC(=C(C=C1)NC(=O)CSC2=NC3=CC=CC=C3C(=O)N2CCCN4CCCCC4)OC
CHEMBL1539256 npy1r_human Human Yes 5.1 IC50 = 7623 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
497 10 1 7 3.9 COC1=CC(=C(C=C1)NC(=O)CSC2=NC3=CC=CC=C3C(=O)N2CCCN4CCCCC4)OC
CHEMBL1329549 npy1r_human Human Yes 5.1 IC50 = 7628 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
497 12 2 8 2.0 CCOC(=O)CCCCC(=O)C1=C(NC(=O)N1)CSC2=NC3=C(C4=CC=CC=C4N3C(C)C)N=N2
CHEMBL1329549 npy1r_human Human Yes 5.1 IC50 = 7628 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
497 12 2 8 2.0 CCOC(=O)CCCCC(=O)C1=C(NC(=O)N1)CSC2=NC3=C(C4=CC=CC=C4N3C(C)C)N=N2
CHEMBL413612 npy1r_human Human Yes 6.1 IC50 = 764 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1915 65 31 25 -4.0 CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL1366620 npy1r_human Human Yes 5.1 IC50 = 7662 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
343 5 2 2 4.8 CCCCCC(=O)NC(=S)NC1=C(C=C(C=C1)Br)C
CHEMBL1366620 npy1r_human Human Yes 5.1 IC50 = 7662 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
343 5 2 2 4.8 CCCCCC(=O)NC(=S)NC1=C(C=C(C=C1)Br)C
CHEMBL1389982 npy1r_human Human Yes 5.1 IC50 = 7683 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
311 1 1 2 5.6 C1CC2=C3C(=NC(=C2C1)C4=CC(=CC=C4)O)C=CC5=CC=CC=C53
CHEMBL1389982 npy1r_human Human Yes 5.1 IC50 = 7683 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
311 1 1 2 5.6 C1CC2=C3C(=NC(=C2C1)C4=CC(=CC=C4)O)C=CC5=CC=CC=C53
CHEMBL441936 npy1r_human Human Yes 6.1 IC50 = 769 Funct
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
1917 66 32 26 -4.1 CC(C)CC(CNC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CC3=CNC=N3)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(C)NC(=O)C
CHEMBL1599610 npy1r_human Human No 5.1 IC50 = 7697 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
283 3 1 2 4.2 C1=CC=C2C(=C1)NC(=N2)C(=O)C=CC3=CC(=CC=C3)Cl
CHEMBL1599610 npy1r_human Human No 5.1 IC50 = 7697 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
283 3 1 2 4.2 C1=CC=C2C(=C1)NC(=N2)C(=O)C=CC3=CC(=CC=C3)Cl
CHEMBL1342925 npy1r_human Human Yes 5.1 IC50 = 7704 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
371 5 0 5 4.1 CC1=C(N=C(O1)C2=CC=CC=C2Cl)CN3C4=C(C=C3C(=O)OC)OC=C4
CHEMBL1342925 npy1r_human Human Yes 5.1 IC50 = 7704 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
371 5 0 5 4.1 CC1=C(N=C(O1)C2=CC=CC=C2Cl)CN3C4=C(C=C3C(=O)OC)OC=C4
CHEMBL206723 npy1r_human Human No 6.1 IC50 = 776.3 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
507 5 1 5 4.2 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5)OC6=CC=C(C=C6)Cl
CHEMBL206723 npy1r_human Human No 6.1 IC50 = 776.3 Funct
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
507 5 1 5 4.2 CN1CCN(CC1)C2CC(C3=C(C2=O)C4=CC=CC=C4N3CC5CCNCC5)OC6=CC=C(C=C6)Cl
CHEMBL238527 npy1r_human Human No 5.1 IC50 = 7762 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
536 5 2 5 5.1 C1CNCC(C1CN2C3=CC=CC=C3C4=CC(=CC(=C42)OC5=CC=C(C=C5)Cl)C(=O)N6CCC(CC6)O)F
CHEMBL238527 npy1r_human Human No 5.1 IC50 = 7762 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
536 5 2 5 5.1 C1CNCC(C1CN2C3=CC=CC=C3C4=CC(=CC(=C42)OC5=CC=C(C=C5)Cl)C(=O)N6CCC(CC6)O)F
CHEMBL1439981 npy1r_human Human Yes 5.1 IC50 = 7767 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
349 6 1 6 4.8 CC(C1=CC=CC=C1)NC2=C(N=C(O2)C3=CC(=C(C=C3)OC)OC)C#N
CHEMBL1439981 npy1r_human Human Yes 5.1 IC50 = 7767 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
349 6 1 6 4.8 CC(C1=CC=CC=C1)NC2=C(N=C(O2)C3=CC(=C(C=C3)OC)OC)C#N
CHEMBL1570844 npy1r_human Human Yes 5.1 IC50 = 7799 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
441 6 1 5 4.4 COC1=CC=C(C=C1)C2=NNC3=C2C(N(C3=O)C4=CC=CC=C4)C5=CC(=C(C=C5)OC)OC
CHEMBL1570844 npy1r_human Human Yes 5.1 IC50 = 7799 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
441 6 1 5 4.4 COC1=CC=C(C=C1)C2=NNC3=C2C(N(C3=O)C4=CC=CC=C4)C5=CC(=C(C=C5)OC)OC
CHEMBL1468490 npy1r_human Human Yes 5.1 IC50 = 7817 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
332 2 0 3 2.2 C1C=C(CC2C1C(=O)N(C2=O)CC3CC4=CC=CC=C4CO3)Cl
CHEMBL1468490 npy1r_human Human Yes 5.1 IC50 = 7817 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
332 2 0 3 2.2 C1C=C(CC2C1C(=O)N(C2=O)CC3CC4=CC=CC=C4CO3)Cl
CHEMBL262083 npy1r_human Human Yes 5.1 IC50 = 7826 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
343 4 4 8 1.2 C1=CC=C(C=C1)NC2=NC=NC3=C2N=CN3C4C(C(C(O4)CO)O)O
CHEMBL262083 npy1r_human Human Yes 5.1 IC50 = 7826 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
343 4 4 8 1.2 C1=CC=C(C=C1)NC2=NC=NC3=C2N=CN3C4C(C(C(O4)CO)O)O
CHEMBL511460 npy1r_human Human No 8.1 IC50 = 8 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
545 13 6 5 3.4 CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL566441 npy1r_human Human No 8.1 IC50 = 8 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
478 7 1 10 2.9 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCS(=O)(=O)CC3)NCC4=NC(=CC=C4)F)C
CHEMBL511460 npy1r_human Human No 8.1 IC50 = 8 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
545 13 6 5 3.4 CCNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL566441 npy1r_human Human No 8.1 IC50 = 8 Funct
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
478 7 1 10 2.9 CC1=C(OC(=N1)SCC2=NC(=CC(=C2)N3CCS(=O)(=O)CC3)NCC4=NC(=CC=C4)F)C
CHEMBL508974 npy1r_human Human No 8.1 IC50 = 8.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL508974 npy1r_human Human No 8.1 IC50 = 8.2 Funct
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
603 16 6 7 3.4 CCOC(=O)CNC(=O)NC(=NCCCC(C(=O)NCC1=CC=C(C=C1)O)NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)N
CHEMBL417912 npy1r_human Human No 8.1 IC50 = 8.4 Funct
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
561 14 2 8 6.5 CCC1=C(N=C(S1)CCC2=NC(=CC(=C2)OC(C)COC)NCC3=CC(=CC(=C3)Cl)NC(=O)OC(C)C)C
CHEMBL332347 npy1r_human Human Yes 8.1 IC50 = 8.8 Funct
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
474 11 5 4 2.5 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O
CHEMBL332347 npy1r_human Human Yes 8.1 IC50 = 8.8 Funct
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
474 11 5 4 2.5 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC3=CC=C(C=C3)O
CHEMBL2314835 npy1r_human Human No 7.1 IC50 = 80 Funct
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBNDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN
3241 109 40 49 -11.5 CCC(C)C(C(=O)NC(CC(=O)N)C(=O)N1CCCC1C(=O)NC(CCCCNC(=O)COCCOCCNC(=O)C(CCCCNC(=O)COCC(=O)NCCOCCOCC(=O)NCC(=O)NC2=CC=C(C=C2)C(=O)NC(CCC(=O)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CC5=CN=CN5)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)N)NC(=O)CN6CCN(CCN(CCN(CC6)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)N
CHEMBL17441 npy1r_human Human No 5.1 IC50 = 8000 Funct
Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1
307 6 3 5 2.9 C1=CC=C(C=C1)C2=CC3=C(C=C2)N=C(N=C3N)NCCCCN
CHEMBL41457 npy1r_human Human No 7.1 IC50 = 81 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
492 11 4 3 3.5 C1=CC=C(C=C1)CNC(=O)C(CCCN=C(N)N)NC(=O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
CHEMBL38531 npy1r_human Human No 5.1 IC50 = 8100 Funct
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
517 12 6 5 1.7 C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NC(C3=CC=C(C=C3)O)C(=O)N
CHEMBL3214137 npy1r_human Human Yes 5.1 IC50 = 8303 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
388 6 1 3 5.2 C1=CC(=C(C(=C1)Cl)C=NNC(=O)CSCC2=CC=C(C=C2)Cl)Cl
CHEMBL3214137 npy1r_human Human Yes 5.1 IC50 = 8303 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
388 6 1 3 5.2 C1=CC(=C(C(=C1)Cl)C=NNC(=O)CSCC2=CC=C(C=C2)Cl)Cl
CHEMBL400631 npy1r_human Human No 6.1 IC50 = 832 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
565 7 2 6 4.4 C1CNCC(C1CN2C3=CC=CC=C3C4=CC(=CC(=C42)OC5=CC=C(C=C5)Cl)C(=O)N6CCN(CC6)CCO)F
CHEMBL400631 npy1r_human Human No 6.1 IC50 = 832 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
565 7 2 6 4.4 C1CNCC(C1CN2C3=CC=CC=C3C4=CC(=CC(=C42)OC5=CC=C(C=C5)Cl)C(=O)N6CCN(CC6)CCO)F
CHEMBL1507807 npy1r_human Human Yes 5.1 IC50 = 8364 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
462 8 0 4 6.7 C1=CC=C(C=C1)C2=C(OC(=N2)CCC(=O)OCC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL1507807 npy1r_human Human Yes 5.1 IC50 = 8364 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
462 8 0 4 6.7 C1=CC=C(C=C1)C2=C(OC(=N2)CCC(=O)OCC3=CC=C(C=C3)Br)C4=CC=CC=C4
CHEMBL17645 npy1r_human Human Yes 5.1 IC50 = 8370 Funct
Compound was tested for human Neuropeptide Y receptor type 1Compound was tested for human Neuropeptide Y receptor type 1
476 7 3 7 5.1 C1CC(CCC1CNC2=NC3=CC=CC=C3C(=N2)N)CNS(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL163470 npy1r_human Human No 5.1 IC50 = 8500 Funct
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
526 8 2 5 5.9 C1CC(CC2=C(C1)C=CC(=C2)Cl)NCC3CCN(CC3)CCNS(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL1563162 npy1r_human Human Yes 5.1 IC50 = 8583 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
482 8 1 7 4.6 C1CCC(CC1)NC(=O)CN(CC2=CC3=C(C=C2)OCO3)C(=O)CSC4=NC5=CC=CC=C5O4
CHEMBL1563162 npy1r_human Human Yes 5.1 IC50 = 8583 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
482 8 1 7 4.6 C1CCC(CC1)NC(=O)CN(CC2=CC3=C(C=C2)OCO3)C(=O)CSC4=NC5=CC=CC=C5O4
CHEMBL238733 npy1r_human Human No 6.1 IC50 = 871 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
561 6 1 5 5.6 C1CC1N2CCN(CC2)C(=O)C3=CC(=C4C(=C3)C5=CC=CC=C5N4CC6CCNCC6F)OC7=CC=C(C=C7)Cl
CHEMBL238733 npy1r_human Human No 6.1 IC50 = 871 Funct
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
561 6 1 5 5.6 C1CC1N2CCN(CC2)C(=O)C3=CC(=C4C(=C3)C5=CC=CC=C5N4CC6CCNCC6F)OC7=CC=C(C=C7)Cl
CHEMBL1509886 npy1r_human Human Yes 5.1 IC50 = 8843 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
349 2 1 3 4.8 CC1=C(C=C2C=C(C=CC2=N1)F)C(=O)NC3=CC(=C(C=C3)Cl)Cl
CHEMBL1509886 npy1r_human Human Yes 5.1 IC50 = 8843 Funct
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem