Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL316589 ccr1_human Human Yes 6.0 EC50 = 1000 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 2.1 CC1=C2C=CC3=C(C2=NC=C1)N=CC=C3
CHEMBL2205808 ccr1_human Human Yes 5.0 EC50 = 10000 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
216 3 0 4 1.4 COC1=CC(=NC=C1)C2=NC=CC(=C2)OC
CHEMBL2205802 ccr1_human Human Yes 5.0 EC50 = 10000 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
240 2 2 4 0.8 C1=CC2=C(C3=C1C=CC(=N3)CO)N=C(C=C2)CO
CHEMBL2205805 ccr1_human Human Yes 5.9 EC50 = 1200 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
268 2 0 3 3.0 C1=CC=NC(=C1)C2=CC(=CC(=N2)C3=CC=CC=N3)Cl
CHEMBL2205806 ccr1_human Human Yes 4.9 EC50 = 12000 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.3 CC1=CC=CC(=N1)C2=NC(=CC=C2)C
CHEMBL2205810 ccr1_human Human Yes 5.9 EC50 = 1300 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 2.1 CC1=CN=C2C(=C1)C=CC3=C2N=CC=C3
CHEMBL2205803 ccr1_human Human Yes 4.9 EC50 = 13000 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
236 2 0 4 2.0 C1=CC2=C(C3=C1C=CC(=N3)C=O)N=C(C=C2)C=O
CHEMBL99384 ccr1_human Human Yes 5.8 EC50 = 1500 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
236 0 0 2 3.9 CC1=CN=C2C(=C1C)C=CC3=C(C(=CN=C32)C)C
CHEMBL1976682 ccr1_human Human Yes 4.8 EC50 = 15000 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
366 2 0 2 3.6 C1=CC2=C(C3=C1C=CC(=N3)CBr)N=C(C=C2)CBr
CHEMBL375781 ccr1_human Human Yes 5.8 EC50 = 1600 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.3 CC1=NC2=C(C=C1)C=CC3=C2N=C(C=C3)C
CHEMBL2205807 ccr1_human Human Yes 4.8 EC50 = 17000 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.2 CC1=CN=C(C=C1)C2=NC=C(C=C2)C
CHEMBL98682 ccr1_human Human Yes 5.8 EC50 = 1800 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 2.8 CC1=C2C=CC=NC2=C3C(=C1)C=CC=N3
CHEMBL66165 ccr1_human Human No 5.7 EC50 = 2000 Funct
Agonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopyAgonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopy
411 7 2 4 6.1 C1=CC2=C(C=CN=C2C=C1Cl)NCCCCNC3=C4C=CC(=CC4=NC=C3)Cl
CHEMBL66165 ccr1_human Human No 5.7 EC50 = 2000 Funct
Agonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopyAgonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopy
411 7 2 4 6.1 C1=CC2=C(C=CN=C2C=C1Cl)NCCCCNC3=C4C=CC(=CC4=NC=C3)Cl
CHEMBL317115 ccr1_human Human Yes 5.7 EC50 = 2000 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
215 0 0 2 3.1 C1=CC2=CC(=C3C=CC=NC3=C2N=C1)Cl
CHEMBL39879 ccr1_human Human Yes 4.5 EC50 = 34000 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
156 1 0 2 1.7 C1=CC=NC(=C1)C2=CC=CC=N2
CHEMBL101165 ccr1_human Human Yes 5.4 EC50 = 3600 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.2 CC1=CC(=NC=C1)C2=NC=CC(=C2)C
CHEMBL2205809 ccr1_human Human Yes 5.3 EC50 = 4900 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.2 CC1=CN=C2C(=C1)C=CC3=CC(=CN=C32)C
CHEMBL2205801 ccr1_human Human Yes 5.3 EC50 = 5000 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
236 2 0 4 1.4 C1=CC2=C(C=CN=C2C3=NC=CC(=C31)C=O)C=O
CHEMBL415879 ccr1_human Human Yes 5.2 EC50 = 5900 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
180 0 0 2 1.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1
CHEMBL89445 ccr1_human Human Yes 4.2 EC50 = 63095.7 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
233 2 0 3 2.4 C1=CC=NC(=C1)C2=NC(=CC=C2)C3=CC=CC=N3
CHEMBL593442 ccr1_human Human Yes 6.1 EC50 = 850 Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.2 CC1=C2C=CC3=C(C=CN=C3C2=NC=C1)C
CHEMBL519240 ccr1_human Human Yes 10.1 IC50 = 0.1 Funct
Displacement of radiolabeled MIP1alpha from human CCR1 receptorDisplacement of radiolabeled MIP1alpha from human CCR1 receptor
327 1 2 6 1.3 C1CCC2C(C1)C3=C(O2)CCC4=C3N=C(N=C4N5CCNCC5)N
CHEMBL519240 ccr1_human Human Yes 10.1 IC50 = 0.1 Funct
Displacement of radiolabeled MIP1alpha from human CCR1 receptorDisplacement of radiolabeled MIP1alpha from human CCR1 receptor
327 1 2 6 1.3 C1CCC2C(C1)C3=C(O2)CCC4=C3N=C(N=C4N5CCNCC5)N
CHEMBL197375 ccr1_human Human No 10.0 IC50 = 0.1 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
444 5 1 4 3.9 CC1CN(C(CN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)C)CC3=CC=C(C=C3)F
CHEMBL197375 ccr1_human Human No 10.0 IC50 = 0.1 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
444 5 1 4 3.9 CC1CN(C(CN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)C)CC3=CC=C(C=C3)F
CHEMBL2332935 ccr1_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
447 6 3 6 2.8 CC(=O)NC1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)Cl)O
CHEMBL2332935 ccr1_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
447 6 3 6 2.8 CC(=O)NC1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)Cl)O
CHEMBL2332933 ccr1_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
432 6 2 7 2.8 CC(=O)NC1=C(C=C(C=C1)F)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)F)O
CHEMBL2332936 ccr1_human Human No 9.3 IC50 = 0.5 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
430 6 3 7 2.3 CC(=O)NC1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)F)O
CHEMBL2332936 ccr1_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
430 6 3 7 2.3 CC(=O)NC1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)F)O
CHEMBL3099947 ccr1_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
472 7 4 7 2.7 C1CC1NC(=O)NC2=C(C=C(C=C2)O)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)F)O
CHEMBL2332931 ccr1_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
449 6 2 6 3.3 CC(=O)NC1=C(C=C(C=C1)F)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)Cl)O
CHEMBL3679659 ccr1_human Human No 9.2 IC50 = 0.7 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
494 5 4 4 3.8 CC(C(C)(C)O)NC(=O)NC1CCCCC1C(=O)N2CCC(C(C2)(C)C)(C3=CC=C(C=C3)Cl)O
CHEMBL3679659 ccr1_human Human No 9.2 IC50 = 0.7 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
494 5 4 4 3.8 CC(C(C)(C)O)NC(=O)NC1CCCCC1C(=O)N2CCC(C(C2)(C)C)(C3=CC=C(C=C3)Cl)O
CHEMBL2332940 ccr1_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
446 6 3 6 2.6 CC(=O)NC1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)Cl)N
CHEMBL2322875 ccr1_human Human No 9.1 IC50 = 0.8 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL5/RANTES-induced chemotaxisAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL5/RANTES-induced chemotaxis
451 4 0 7 4.0 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C(F)(F)F)Cl
CHEMBL2398726 ccr1_human Human No 9.1 IC50 = 0.8 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
451 5 3 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)O
CHEMBL2398729 ccr1_human Human No 9.1 IC50 = 0.8 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
451 5 3 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)O
CHEMBL3099945 ccr1_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
488 7 4 6 3.2 C1CC1NC(=O)NC2=C(C=C(C=C2)O)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL196860 ccr1_human Human No 9.1 IC50 = 0.9 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
431 5 2 4 2.9 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL196860 ccr1_human Human No 9.1 IC50 = 0.9 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
431 5 2 4 2.9 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL331897 ccr1_human Human No 9.1 IC50 = 0.9 Funct
Binding affinity towards C-C chemokine receptor type 1Binding affinity towards C-C chemokine receptor type 1
529 5 1 2 7.3 CC[N+]1(CCC(CC1)NC(=O)C2C3=C(C=CC(=C3)Cl)OC4=C2C=C(C=C4)Cl)CC5=CCCCCCC5
CHEMBL2332930 ccr1_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
461 7 2 6 3.2 CC(=O)NC1=C(C=C(C=C1)OC)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)Cl)O
CHEMBL2391803 ccr1_human Human No 9.0 IC50 = 0.9 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
537 6 3 7 3.3 C1CN(CC1O)C(=O)C2=CC(=C(C=C2OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O)O)Cl
CHEMBL2332934 ccr1_human Human No 9.0 IC50 = 1.0 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
414 6 2 6 2.7 CC(=O)NC1=CC=CC=C1OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)F)O
CHEMBL2332932 ccr1_human Human No 9.0 IC50 = 1.0 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
431 6 2 5 3.2 CC(=O)NC1=CC=CC=C1OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)Cl)O
CHEMBL197345 ccr1_human Human No 9.0 IC50 = 1 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
444 5 1 4 3.9 CC1CN(C(CN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)C)CC3=CC=C(C=C3)F
CHEMBL198949 ccr1_human Human Yes 9.0 IC50 = 1 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
430 5 1 4 3.5 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL372807 ccr1_human Human No 9.0 IC50 = 1 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
472 6 1 5 3.6 CC(=O)NC1=CC(=C(C=C1C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F)OC)Cl
CHEMBL3334818 ccr1_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
472 6 3 3 4.4 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC3=CC=CC=C3
CHEMBL3334824 ccr1_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL3679651 ccr1_human Human No 9.0 IC50 = 1 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
534 5 3 6 3.3 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)C4=CC(=CC=C4)S(=O)(=O)N)C
CHEMBL2398726 ccr1_human Human No 9.0 IC50 = 1 Funct
Antagonist activity at human CCR1 assessed as inhibition of RANTES-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of RANTES-induced chemotaxis
451 5 3 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)O
CHEMBL197345 ccr1_human Human No 9.0 IC50 = 1 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
444 5 1 4 3.9 CC1CN(C(CN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)C)CC3=CC=C(C=C3)F
CHEMBL198949 ccr1_human Human Yes 9.0 IC50 = 1 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
430 5 1 4 3.5 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL372807 ccr1_human Human No 9.0 IC50 = 1 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
472 6 1 5 3.6 CC(=O)NC1=CC(=C(C=C1C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F)OC)Cl
CHEMBL2398717 ccr1_human Human No 9.0 IC50 = 1 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
421 6 2 3 4.1 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CC3CC3
CHEMBL3679651 ccr1_human Human No 9.0 IC50 = 1 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
534 5 3 6 3.3 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)C4=CC(=CC=C4)S(=O)(=O)N)C
CHEMBL3334818 ccr1_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
472 6 3 3 4.4 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC3=CC=CC=C3
CHEMBL3334824 ccr1_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL66159 ccr1_human Human No 9.0 IC50 = 1 Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
482 11 4 7 2.8 CC(C)(CCC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)NN)F
CHEMBL2391810 ccr1_human Human No 9.0 IC50 = 1.1 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
517 6 3 7 3.0 C1CN(CCC1O)C(=O)C2=C(C=C(C=C2)O)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL2398728 ccr1_human Human No 9.0 IC50 = 1.1 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
451 5 3 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)O
CHEMBL2398744 ccr1_human Human No 8.9 IC50 = 1.2 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
437 7 2 3 4.7 CC(C)CCC(=O)NC(C(C)C)C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O
CHEMBL2398769 ccr1_human Human No 8.9 IC50 = 1.2 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
458 6 2 4 3.6 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CC3=CC=NC=C3
CHEMBL3679655 ccr1_human Human No 8.9 IC50 = 1.3 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
447 4 2 3 4.6 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)C4CCCC4)C
CHEMBL2391797 ccr1_human Human No 8.9 IC50 = 1.3 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
530 7 2 7 3.4 CN(C)C1CCN(C1)C(=O)C2=C(C=C(C=C2)O)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL3679655 ccr1_human Human No 8.9 IC50 = 1.3 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
447 4 2 3 4.6 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)C4CCCC4)C
CHEMBL3099942 ccr1_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
462 6 4 6 2.7 CNC(=O)NC1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)Cl)O
CHEMBL2391795 ccr1_human Human No 8.9 IC50 = 1.4 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
473 7 3 6 3.5 C1CC1NC(=O)C2=C(C=C(C=C2)O)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL2391939 ccr1_human Human No 8.9 IC50 = 1.4 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
475 7 2 6 3.9 C1CC1NC(=O)C2=C(C=C(C=C2)F)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL2398747 ccr1_human Human No 8.9 IC50 = 1.4 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
435 5 2 3 4.6 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCCC3
CHEMBL3099940 ccr1_human Human No 8.9 IC50 = 1.4 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
486 6 2 5 3.7 C1CCN(C1)C(=O)NC2=CC=CC=C2OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL2332941 ccr1_human Human No 8.9 IC50 = 1.4 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
429 6 3 7 2.1 CC(=O)NC1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)F)N
CHEMBL232656 ccr1_human Human Yes 8.8 IC50 = 1.5 Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
435 6 2 5 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL200629 ccr1_human Human No 8.8 IC50 = 1.5 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
460 6 1 5 3.4 CC1CN(CCN1C(=O)C=CC2=CC(=C(C=C2NC(=O)C)Cl)OC)CC3=CC=C(C=C3)F
CHEMBL3679653 ccr1_human Human No 8.8 IC50 = 1.5 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
463 4 3 4 3.3 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)C4CCC(C4)O)C
CHEMBL2322875 ccr1_human Human No 8.8 IC50 = 1.5 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced chemotaxisAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced chemotaxis
451 4 0 7 4.0 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C(F)(F)F)Cl
CHEMBL232656 ccr1_human Human Yes 8.8 IC50 = 1.5 Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
435 6 2 5 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL200629 ccr1_human Human No 8.8 IC50 = 1.5 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
460 6 1 5 3.4 CC1CN(CCN1C(=O)C=CC2=CC(=C(C=C2NC(=O)C)Cl)OC)CC3=CC=C(C=C3)F
CHEMBL3679653 ccr1_human Human No 8.8 IC50 = 1.5 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
463 4 3 4 3.3 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)C4CCC(C4)O)C
CHEMBL3679654 ccr1_human Human No 8.8 IC50 = 1.6 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
499 5 3 5 4.3 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)C4=CC(=CC=C4)C(=O)O)C
CHEMBL2398728 ccr1_human Human No 8.8 IC50 = 1.6 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
451 5 3 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)O
CHEMBL3679654 ccr1_human Human No 8.8 IC50 = 1.6 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
499 5 3 5 4.3 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)C4=CC(=CC=C4)C(=O)O)C
CHEMBL2398744 ccr1_human Human No 8.8 IC50 = 1.7 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
437 7 2 3 4.7 CC(C)CCC(=O)NC(C(C)C)C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O
CHEMBL2398739 ccr1_human Human No 8.8 IC50 = 1.7 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
485 8 2 3 5.3 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CCCC3=CC=CC=C3
CHEMBL3679656 ccr1_human Human No 8.7 IC50 = 1.8 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
498 5 3 4 3.6 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)C4=CC=CC(=C4)C(=O)N)C
CHEMBL2391793 ccr1_human Human No 8.8 IC50 = 1.8 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
447 6 3 6 2.9 CNC(=O)C1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)Cl)O
CHEMBL2391808 ccr1_human Human No 8.8 IC50 = 1.8 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
487 6 2 6 3.6 C1CCN(C1)C(=O)C2=C(C=C(C=C2)O)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL2398737 ccr1_human Human No 8.8 IC50 = 1.8 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
457 6 2 3 4.6 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CC3=CC=CC=C3
CHEMBL2398746 ccr1_human Human No 8.8 IC50 = 1.8 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
421 5 2 3 4.0 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC3
CHEMBL3679656 ccr1_human Human No 8.8 IC50 = 1.8 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
498 5 3 4 3.6 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)C4=CC=CC(=C4)C(=O)N)C
CHEMBL3099943 ccr1_human Human No 8.8 IC50 = 1.8 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
522 7 4 6 3.8 C1CC1NC(=O)NC2=CC(=C(C=C2OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O)O)Cl
CHEMBL3099944 ccr1_human Human No 8.8 IC50 = 1.8 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
502 8 3 6 3.5 COC1=CC(=C(C=C1)NC(=O)NC2CC2)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL2391804 ccr1_human Human No 8.7 IC50 = 1.9 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
503 6 3 7 2.6 C1CN(CC1O)C(=O)C2=C(C=C(C=C2)O)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL2398743 ccr1_human Human No 8.7 IC50 = 1.9 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
423 6 2 3 4.3 CC(C)CC(=O)NC(C(C)C)C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O
CHEMBL3334727 ccr1_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL200242 ccr1_human Human No 8.0 IC50 = 10 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
485 7 1 5 3.7 CN(C)CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F
CHEMBL232441 ccr1_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
487 7 2 8 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)N)CC4=CC=C(C=C4)F
CHEMBL3334727 ccr1_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL2398771 ccr1_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
477 5 2 3 5.3 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC(=CC=C3)Cl
CHEMBL2398761 ccr1_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
443 5 2 3 4.7 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=CC=C3
CHEMBL200242 ccr1_human Human No 8.0 IC50 = 10 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
485 7 1 5 3.7 CN(C)CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F
CHEMBL2398762 ccr1_human Human No 8.0 IC50 = 10 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
433 5 2 4 4.7 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC(=C(C=C3)F)O
CHEMBL2322867 ccr1_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
467 5 1 8 2.8 COC1=C(C=CC(=C1)N2CCN(CC2)C(=O)CN3C(=C(C(=N3)C(F)(F)F)Cl)CO)Cl
CHEMBL2321887 ccr1_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
461 5 0 6 2.7 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)S(=O)(=O)C)Cl
CHEMBL2322847 ccr1_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
408 4 0 5 3.1 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C#N)Cl
CHEMBL2322880 ccr1_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
486 4 0 7 4.6 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C(=C3)Cl)Cl)OC)C(F)(F)F)Cl
CHEMBL232441 ccr1_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
487 7 2 8 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)N)CC4=CC=C(C=C4)F
CHEMBL256821 ccr1_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
443 7 2 5 3.7 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC(=CC=C3)Cl
CHEMBL257509 ccr1_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
461 7 2 6 3.8 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=C(C=C(C=C3)F)Cl
CHEMBL197345 ccr1_human Human No 7.0 IC50 = 100 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
444 5 1 4 3.9 CC1CN(C(CN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)C)CC3=CC=C(C=C3)F
CHEMBL256821 ccr1_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
443 7 2 5 3.7 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC(=CC=C3)Cl
CHEMBL257509 ccr1_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
461 7 2 6 3.8 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=C(C=C(C=C3)F)Cl
CHEMBL197345 ccr1_human Human No 7.0 IC50 = 100 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
444 5 1 4 3.9 CC1CN(C(CN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)C)CC3=CC=C(C=C3)F
CHEMBL2322874 ccr1_human Human No 7.0 IC50 = 100 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
435 3 0 6 4.4 CC1=C(C=CC(=C1)N2CCN(CC2)C(=O)CN3C(=C(C(=N3)C(F)(F)F)Cl)C)Cl
CHEMBL2180511 ccr1_human Human No 7.0 IC50 = 100 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
427 5 1 2 5.7 CC1=CC=CC(=C1C)C(=O)NC(C(C)C)C(=O)N2CCC(CC2)C3=CC=C(C=C3)Cl
CHEMBL199412 ccr1_mouse Mouse No 6.0 IC50 = 1000 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
447 5 1 5 3.1 CC1CN(CCN1C(=O)C=CC2=C(C=C3C(=C2)C=CC=N3)NC(=O)C)CC4=CC=C(C=C4)F
CHEMBL198966 ccr1_human Human No 6.0 IC50 = 1000 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
444 4 1 5 3.8 CC1CN(CCN1C(=O)C2=CC3=CC(=CC(=C3O2)NC(=O)C)Cl)CC4=CC=C(C=C4)F
CHEMBL200794 ccr1_human Human No 6.0 IC50 = 1000 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
443 4 2 4 3.5 CC1CN(CCN1C(=O)C2=CC3=CC(=CC(=C3N2)NC(=O)C)Cl)CC4=CC=C(C=C4)F
CHEMBL397910 ccr1_mouse Mouse No 6.0 IC50 = 1000 Funct
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
578 10 2 9 3.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCC4=CN=CC=C4)CC5=CC=C(C=C5)F
CHEMBL270563 ccr1_human Human No 6.0 IC50 = 1000 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
478 4 0 5 4.6 C1CN(CCC1N2CCC(CC2)(C#N)C3=CC=C(C=C3)Cl)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL199412 ccr1_mouse Mouse No 6.0 IC50 = 1000 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
447 5 1 5 3.1 CC1CN(CCN1C(=O)C=CC2=C(C=C3C(=C2)C=CC=N3)NC(=O)C)CC4=CC=C(C=C4)F
CHEMBL198966 ccr1_human Human No 6.0 IC50 = 1000 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
444 4 1 5 3.8 CC1CN(CCN1C(=O)C2=CC3=CC(=CC(=C3O2)NC(=O)C)Cl)CC4=CC=C(C=C4)F
CHEMBL200794 ccr1_human Human No 6.0 IC50 = 1000 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
443 4 2 4 3.5 CC1CN(CCN1C(=O)C2=CC3=CC(=CC(=C3N2)NC(=O)C)Cl)CC4=CC=C(C=C4)F
CHEMBL397910 ccr1_mouse Mouse No 6.0 IC50 = 1000 Funct
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
578 10 2 9 3.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCC4=CN=CC=C4)CC5=CC=C(C=C5)F
CHEMBL270563 ccr1_human Human No 6.0 IC50 = 1000 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
478 4 0 5 4.6 C1CN(CCC1N2CCC(CC2)(C#N)C3=CC=C(C=C3)Cl)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL195433 ccr1_human Human Yes 5.0 IC50 = 10000 Funct
Inhibition of C-C chemokine receptor type 1Inhibition of C-C chemokine receptor type 1
487 7 2 6 5.3 CC1=C(SC(=N1)NC(=O)NC2CCCCC2CN3CCCC(C3)CC4=CC=C(C=C4)F)C(=O)C
CHEMBL363840 ccr1_human Human No 5.0 IC50 = 10000 Funct
Inhibition of C-C chemokine receptor type 1Inhibition of C-C chemokine receptor type 1
506 7 2 6 4.8 CN1C(=NN=N1)C2=CC(=CC=C2)NC(=O)NC3CCCCC3CN4CCCC(C4)CC5=CC=C(C=C5)F
CHEMBL83338 ccr1_human Human No 5.0 IC50 = 10000 Funct
Compound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR1 receptorCompound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR1 receptor
557 8 0 6 4.9 CN(CC(CCN1CCC2(CC1)CS(=O)C3=CC=CC=C23)C4=CC(=CC=C4)Cl)S(=O)(=O)C5=CC=CC=C5
CHEMBL195433 ccr1_human Human Yes 5.0 IC50 = 10000 Funct
Inhibition of C-C chemokine receptor type 1Inhibition of C-C chemokine receptor type 1
487 7 2 6 5.3 CC1=C(SC(=N1)NC(=O)NC2CCCCC2CN3CCCC(C3)CC4=CC=C(C=C4)F)C(=O)C
CHEMBL363840 ccr1_human Human No 5.0 IC50 = 10000 Funct
Inhibition of C-C chemokine receptor type 1Inhibition of C-C chemokine receptor type 1
506 7 2 6 4.8 CN1C(=NN=N1)C2=CC(=CC=C2)NC(=O)NC3CCCCC3CN4CCCC(C4)CC5=CC=C(C=C5)F
CHEMBL3137848 ccr1_human Human No 5.0 IC50 = 10000 Funct
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
882 16 6 8 15.2 CC(C)CCCC(C)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)CCC=C(C5=CC(=C(C(=C5)Cl)O)C(=O)NCC(=O)O)C6=CC(=C(C(=C6)Cl)O)C(=O)NCC(=O)O)C)C
CHEMBL101165 ccr1_human Human Yes 4.0 IC50 = 100000 Funct
Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsDisplacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
184 1 0 2 2.2 CC1=CC(=NC=C1)C2=NC=CC(=C2)C
CHEMBL593442 ccr1_human Human Yes 4.0 IC50 = 100000 Funct
Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsDisplacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
208 0 0 2 3.2 CC1=C2C=CC3=C(C=CN=C3C2=NC=C1)C
CHEMBL3099947 q9jly8_rat Rat No 7.0 IC50 = 101 Funct
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
472 7 4 7 2.7 C1CC1NC(=O)NC2=C(C=C(C=C2)O)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)F)O
CHEMBL258368 ccr1_human Human No 6.0 IC50 = 1020 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
441 4 1 6 3.5 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=CC=CS4
CHEMBL258368 ccr1_human Human No 6.0 IC50 = 1020 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
441 4 1 6 3.5 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=CC=CS4
CHEMBL306683 ccr1_human Human No 5.0 IC50 = 10300 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
447 10 3 3 5.2 CC(C)CC(CC(C(CC1=CC=CC=C1)NC(=O)C2=CC3=CC=CC=C3C=C2)O)C(=O)NC
CHEMBL2180194 ccr1_human Human No 7.0 IC50 = 105 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
441 7 1 2 5.6 CC1=CC=C(C=C1)CCC(=O)NC(C(C)C)C(=O)N2CCC(CC2)C3=CC=C(C=C3)Cl
CHEMBL197345 ccr1_human Human No 5.0 IC50 = 10500 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
444 5 1 4 3.9 CC1CN(C(CN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)C)CC3=CC=C(C=C3)F
CHEMBL197345 ccr1_human Human No 5.0 IC50 = 10500 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
444 5 1 4 3.9 CC1CN(C(CN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)C)CC3=CC=C(C=C3)F
CHEMBL3679640 ccr1_human Human No 6.0 IC50 = 1065 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
527 4 2 5 4.2 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CC4(CCC3NC(=O)C5=CC=CC=C5)OCCO4)C
CHEMBL3679640 ccr1_human Human No 6.0 IC50 = 1065 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
527 4 2 5 4.2 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CC4(CCC3NC(=O)C5=CC=CC=C5)OCCO4)C
CHEMBL2398768 ccr1_human Human No 7.0 IC50 = 107 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
414 6 1 3 3.8 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)CC3=CC=NC=C3
CHEMBL2322878 ccr1_human Human No 7.0 IC50 = 107 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
465 4 0 7 4.4 CC1=CC(=CC(=C1Cl)OC)N2CCN(CC2)C(=O)CN3C(=C(C(=N3)C(F)(F)F)Cl)C
CHEMBL2180518 ccr1_human Human No 6.0 IC50 = 1077 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
429 7 1 3 5.2 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)OCC3=CC=CC=C3
CHEMBL143499 ccr1_human Human No 5.0 IC50 = 10900 Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
436 7 1 4 4.7 C1CN(CCC1(C2=CC=C(C=C2)C#N)O)CCCC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL475748 ccr1_human Human No 8.0 IC50 = 11 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
468 4 1 5 4.9 CC1=CC(=CC(=C1NC(=O)N2CCCC2C(=O)N(C)CC3=CC=C(C=C3)Cl)C)C(F)(F)F
CHEMBL3334820 ccr1_human Human No 8.0 IC50 = 11 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
425 6 3 4 2.7 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CC(C)O
CHEMBL2322854 ccr1_human Human No 8.0 IC50 = 11 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
481 5 1 8 3.4 CC1=C(C(=NN1CC(=O)N2CCN(CC2CO)C3=CC(=C(C=C3)Cl)OC)C(F)(F)F)Cl
CHEMBL475748 ccr1_human Human No 8.0 IC50 = 11 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
468 4 1 5 4.9 CC1=CC(=CC(=C1NC(=O)N2CCCC2C(=O)N(C)CC3=CC=C(C=C3)Cl)C)C(F)(F)F
CHEMBL3334820 ccr1_human Human No 8.0 IC50 = 11 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
425 6 3 4 2.7 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CC(C)O
CHEMBL3679657 ccr1_human Human No 8.0 IC50 = 11.3 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
504 5 3 6 3.9 CC1(CN(CCC1(C2=CC=C(C=C2)[N+]#[C-])O)C(=O)C3CCCCC3NC(=O)C4=CC(=CC=C4)C(=O)O)C
CHEMBL3679657 ccr1_human Human No 8.0 IC50 = 11.3 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
504 5 3 6 3.9 CC1(CN(CCC1(C2=CC=C(C=C2)[N+]#[C-])O)C(=O)C3CCCCC3NC(=O)C4=CC(=CC=C4)C(=O)O)C
CHEMBL3679639 ccr1_human Human No 7.9 IC50 = 11.5 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
470 4 3 3 4.5 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)NC4=CC=CC=C4)C
CHEMBL3679639 ccr1_human Human No 7.9 IC50 = 11.5 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
470 4 3 3 4.5 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)NC4=CC=CC=C4)C
CHEMBL255338 ccr1_human Human No 7.0 IC50 = 110 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
491 8 2 6 4.4 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3C4=CSC=C4
CHEMBL269957 ccr1_human Human No 7.0 IC50 = 110 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
443 7 2 5 3.7 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3Cl
CHEMBL2391805 ccr1_human Human No 7.0 IC50 = 110 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
530 7 2 7 3.4 CN(C)C1CCN(C1)C(=O)C2=C(C=C(C=C2)O)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL255338 ccr1_human Human No 7.0 IC50 = 110 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
491 8 2 6 4.4 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3C4=CSC=C4
CHEMBL269957 ccr1_human Human No 7.0 IC50 = 110 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
443 7 2 5 3.7 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3Cl
CHEMBL2391809 q9jly8_rat Rat No 6.0 IC50 = 1100 Funct
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
501 6 2 6 4.0 C1CCN(CC1)C(=O)C2=C(C=C(C=C2)O)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL2322865 ccr1_human Human No 6.0 IC50 = 1100 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
479 5 0 7 4.8 CC(C)C1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C(F)(F)F)Cl
CHEMBL286355 ccr1_human Human No 6.0 IC50 = 1100 Funct
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
419 6 1 2 6.9 C1CCCC(CCC1)CN2CCC(CC2)NC(=O)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL2322873 ccr1_human Human No 5.0 IC50 = 11000 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
421 3 0 6 4.0 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=CC=C3)Cl)C(F)(F)F)Cl
CHEMBL256887 ccr1_human Human No 6.0 IC50 = 1120 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
550 4 1 7 4.3 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=C(C=C(C=C4Br)F)F
CHEMBL256887 ccr1_human Human No 6.0 IC50 = 1120 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
550 4 1 7 4.3 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=C(C=C(C=C4Br)F)F
CHEMBL2391795 q9jly8_rat Rat No 6.9 IC50 = 114 Funct
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
473 7 3 6 3.5 C1CC1NC(=O)C2=C(C=C(C=C2)O)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL2180188 ccr1_human Human No 6.9 IC50 = 115 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
447 6 1 2 5.5 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)CC3=CC=C(C=C3)Cl
CHEMBL271079 ccr1_human Human No 5.9 IC50 = 1150 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
459 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL271079 ccr1_human Human No 5.9 IC50 = 1150 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
459 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL270358 ccr1_human Human No 5.9 IC50 = 1170 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
453 4 1 6 3.5 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)F)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL270358 ccr1_human Human No 5.9 IC50 = 1170 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
453 4 1 6 3.5 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)F)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL2180507 ccr1_human Human No 6.9 IC50 = 118 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
417 5 1 3 5.1 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC=C(C=C3)F
CHEMBL66457 ccr1_human Human No 5.9 IC50 = 1180 Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
465 11 4 6 2.1 CC(C)(CCC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)N)O
CHEMBL308690 ccr1_human Human No 4.9 IC50 = 11800 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
414 10 3 4 3.9 CC(C)CC(CC(C(CC(C)C)NC(=O)C1=CC2=CC=CC=C2N=C1)O)C(=O)NC
CHEMBL234295 ccr1_human Human No 7.9 IC50 = 12 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
600 11 2 10 3.1 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCOCC4)CC5=CC=C(C=C5)F
CHEMBL234295 ccr1_human Human No 7.9 IC50 = 12 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
600 11 2 10 3.1 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCOCC4)CC5=CC=C(C=C5)F
CHEMBL234295 ccr1_human Human No 7.9 IC50 = 12 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
600 11 2 10 3.1 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCOCC4)CC5=CC=C(C=C5)F
CHEMBL234295 ccr1_human Human No 7.9 IC50 = 12 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
600 11 2 10 3.1 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCOCC4)CC5=CC=C(C=C5)F
CHEMBL2391812 ccr1_human Human No 7.9 IC50 = 12 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
477 8 4 7 2.3 C1CN(CCC12CC3=C(O2)C=CC(=C3)Cl)CC(COC4=C(C=CC(=C4)O)C(=O)NCCO)O
CHEMBL2391802 ccr1_human Human No 7.9 IC50 = 12 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
489 6 2 8 2.6 C1CN(CC1O)C(=O)C2=C(C=C(C=C2)F)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)F)O
CHEMBL2398727 ccr1_human Human No 7.9 IC50 = 12 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
451 5 3 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)O
CHEMBL234295 ccr1_human Human No 7.9 IC50 = 12 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
600 11 2 10 3.1 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCOCC4)CC5=CC=C(C=C5)F
CHEMBL2322875 ccr1_human Human No 7.9 IC50 = 12 Funct
Displacement of [125I]-CCL15/Leukotactin1 from CCR1 in human THP1 cellsDisplacement of [125I]-CCL15/Leukotactin1 from CCR1 in human THP1 cells
451 4 0 7 4.0 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C(F)(F)F)Cl
CHEMBL2322886 ccr1_human Human No 7.9 IC50 = 12 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
481 5 1 8 3.1 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C(=C3)CO)Cl)OC)C(F)(F)F)Cl
CHEMBL2322876 ccr1_human Human No 7.9 IC50 = 12 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
465 5 0 7 4.4 CCOC1=C(C=CC(=C1)N2CCN(CC2)C(=O)CN3C(=C(C(=N3)C(F)(F)F)Cl)C)Cl
CHEMBL234295 ccr1_human Human No 7.9 IC50 = 12 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
600 11 2 10 3.1 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCOCC4)CC5=CC=C(C=C5)F
CHEMBL3679638 ccr1_human Human No 7.9 IC50 = 12.1 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
451 5 2 4 4.5 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)OC(C)(C)C)C
CHEMBL3679638 ccr1_human Human No 7.9 IC50 = 12.1 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
451 5 2 4 4.5 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)OC(C)(C)C)C
CHEMBL256272 ccr1_human Human No 6.9 IC50 = 120 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
528 4 1 5 4.6 CC1CC(CCN1S(=O)(=O)C2=CC=CC=C2Br)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL258064 ccr1_human Human No 6.9 IC50 = 120 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
423 7 2 5 3.4 CC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O
CHEMBL198966 ccr1_human Human No 6.9 IC50 = 120 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
444 4 1 5 3.8 CC1CN(CCN1C(=O)C2=CC3=CC(=CC(=C3O2)NC(=O)C)Cl)CC4=CC=C(C=C4)F
CHEMBL473531 ccr1_human Human No 6.9 IC50 = 120 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
474 4 1 5 4.8 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=C(C=C(C=C3)C(F)(F)F)Cl
CHEMBL256272 ccr1_human Human No 6.9 IC50 = 120 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
528 4 1 5 4.6 CC1CC(CCN1S(=O)(=O)C2=CC=CC=C2Br)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL258064 ccr1_human Human No 6.9 IC50 = 120 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
423 7 2 5 3.4 CC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O
CHEMBL198966 ccr1_human Human No 6.9 IC50 = 120 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
444 4 1 5 3.8 CC1CN(CCN1C(=O)C2=CC3=CC(=CC(=C3O2)NC(=O)C)Cl)CC4=CC=C(C=C4)F
CHEMBL2322871 ccr1_human Human No 6.9 IC50 = 120 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
383 4 0 4 3.1 CC1=C(C=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)Cl
CHEMBL2322850 ccr1_human Human No 6.9 IC50 = 120 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
412 5 1 5 2.0 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)CN)Cl
CHEMBL473531 ccr1_human Human No 6.9 IC50 = 120 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
474 4 1 5 4.8 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=C(C=C(C=C3)C(F)(F)F)Cl
CHEMBL2180538 ccr1_human Human No 6.9 IC50 = 120 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
399 6 1 2 4.9 CCCC(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3
CHEMBL306457 ccr1_human Human No 6.9 IC50 = 120 Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
477 9 4 6 3.0 C1CCC(CC1)(C(CC(C(CC2=CC=CC=C2)NC(=O)C3=NC4=CC=CC=C4N=C3)O)C(=O)N)O
CHEMBL2180527 ccr1_human Human No 6.9 IC50 = 121 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
385 5 1 2 4.5 CCC(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3
CHEMBL2180494 ccr1_human Human No 6.9 IC50 = 121 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
439 5 1 2 6.0 C1CCC(CC1)C(C(=O)N2CCC(CC2)C3=CC=C(C=C3)Cl)NC(=O)C4=CC=CC=C4
CHEMBL2398766 ccr1_human Human No 6.9 IC50 = 123 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
478 6 2 5 3.5 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC(=CC=C3)S(=O)(=O)N
CHEMBL270419 ccr1_human Human No 5.9 IC50 = 1240 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
435 4 1 5 3.4 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=CC=CC=C4
CHEMBL270419 ccr1_human Human No 5.9 IC50 = 1240 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
435 4 1 5 3.4 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=CC=CC=C4
CHEMBL341306 ccr1_human Human No 6.9 IC50 = 125 Funct
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
588 11 3 3 7.7 C1CCC(CC1)CNC(=O)NCC(CCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL270358 ccr1_human Human No 5.9 IC50 = 1250 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
453 4 1 6 3.5 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)F)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL270358 ccr1_human Human No 5.9 IC50 = 1250 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
453 4 1 6 3.5 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)F)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL69876 ccr1_human Human No 4.9 IC50 = 12500 Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
463 9 3 6 2.1 C1COCCC1C(CC(C(CC2=CC=CC=C2)NC(=O)C3=NC4=CC=CC=C4N=C3)O)C(=O)N
CHEMBL3099951 q9jly8_rat Rat No 5.9 IC50 = 1260 Funct
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
445 5 2 6 3.0 C1CN(CCC12CC3=C(O2)C=CC(=C3)Cl)CC(COC4=CC=CC5=C4NC(=O)CO5)O
CHEMBL270419 ccr1_human Human No 5.9 IC50 = 1270 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
435 4 1 5 3.4 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=CC=CC=C4
CHEMBL270419 ccr1_human Human No 5.9 IC50 = 1270 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
435 4 1 5 3.4 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=CC=CC=C4
CHEMBL3138123 ccr1_human Human No 4.9 IC50 = 12700 Funct
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
1030 22 6 10 17.3 CC(C)CCCC(C)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)CCC=C(C5=CC(=C(C(=C5)Cl)O)C(=O)NC(CCSC)C(=O)O)C6=CC(=C(C(=C6)Cl)O)C(=O)NC(CCSC)C(=O)O)C)C
CHEMBL427834 ccr1_human Human No 5.9 IC50 = 1290 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
469 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL427834 ccr1_human Human No 5.9 IC50 = 1290 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
469 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL232638 ccr1_human Human No 7.9 IC50 = 13 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
531 10 3 9 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCO)CC4=CC=C(C=C4)F
CHEMBL370596 ccr1_human Human No 7.9 IC50 = 13 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
446 5 1 4 4.1 CC1CN(CCN1C(=O)C=CC2=CC3=CC=CC=C3C=C2NC(=O)C)CC4=CC=C(C=C4)F
CHEMBL234263 ccr1_human Human No 7.9 IC50 = 13 Funct
Binding Affinity at CCL3Binding Affinity at CCL3
491 9 1 7 1.2 CC1CN(C(CN1C(=O)COC2=C(C=C(C=C2)Cl)C(=O)CCC(=O)O)C)CC3=CC=C(C=C3)F
CHEMBL68366 ccr1_human Human No 7.9 IC50 = 13 Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
467 11 3 6 3.1 CC(C)(CCC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)N)F
CHEMBL2398763 ccr1_human Human No 7.9 IC50 = 13 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
477 5 3 5 4.5 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC(=C(C=C3)F)O
CHEMBL232638 ccr1_human Human No 7.9 IC50 = 13 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
531 10 3 9 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCO)CC4=CC=C(C=C4)F
CHEMBL370596 ccr1_human Human No 7.9 IC50 = 13 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
446 5 1 4 4.1 CC1CN(CCN1C(=O)C=CC2=CC3=CC=CC=C3C=C2NC(=O)C)CC4=CC=C(C=C4)F
CHEMBL234263 ccr1_human Human No 7.9 IC50 = 13 Funct
Binding Affinity at CCL3Binding Affinity at CCL3
491 9 1 7 1.2 CC1CN(C(CN1C(=O)COC2=C(C=C(C=C2)Cl)C(=O)CCC(=O)O)C)CC3=CC=C(C=C3)F
CHEMBL2398740 ccr1_human Human No 7.9 IC50 = 13 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
381 4 2 3 3.0 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C
CHEMBL2322875 ccr1_human Human No 7.9 IC50 = 13 Funct
Displacement of [125I]-CCL15/Leukotactin1 from CCR1 in human monocytesDisplacement of [125I]-CCL15/Leukotactin1 from CCR1 in human monocytes
451 4 0 7 4.0 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C(F)(F)F)Cl
CHEMBL2180186 ccr1_human Human No 7.9 IC50 = 13 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
431 6 1 3 5.0 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)CC3=CC=CC=C3F
CHEMBL3099960 ccr1_human Human No 7.9 IC50 = 13 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
460 7 3 7 2.5 CNC(=O)NC1=C(C=C(C=C1)OC)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)F)O
CHEMBL68366 ccr1_human Human No 7.9 IC50 = 13 Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
467 11 3 6 3.1 CC(C)(CCC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)N)F
CHEMBL404465 ccr1_human Human No 6.9 IC50 = 130 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
483 4 1 5 4.4 C1CC(CCN(C1)C2CCN(CC2)S(=O)(=O)C3=CC=CC=C3Cl)(C4=CC=C(C=C4)Cl)O
CHEMBL270253 ccr1_human Human No 6.9 IC50 = 130 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
469 4 1 5 4.1 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL397910 q9jly8_rat Rat No 6.9 IC50 = 130 Funct
Binding affinity at rat CCR1Binding affinity at rat CCR1
578 10 2 9 3.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCC4=CN=CC=C4)CC5=CC=C(C=C5)F
CHEMBL2391801 ccr1_human Human No 6.9 IC50 = 130 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
471 6 2 7 2.5 C1CN(CC1O)C(=O)C2=C(C=C(C=C2)F)OCC(CN3CCC4(CC3)CC5=CC=CC=C5O4)O
CHEMBL404465 ccr1_human Human No 6.9 IC50 = 130 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
483 4 1 5 4.4 C1CC(CCN(C1)C2CCN(CC2)S(=O)(=O)C3=CC=CC=C3Cl)(C4=CC=C(C=C4)Cl)O
CHEMBL270253 ccr1_human Human No 6.9 IC50 = 130 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
469 4 1 5 4.1 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL397910 q9jly8_rat Rat No 6.9 IC50 = 130 Funct
Binding affinity at rat CCR1Binding affinity at rat CCR1
578 10 2 9 3.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCC4=CN=CC=C4)CC5=CC=C(C=C5)F
CHEMBL2180539 ccr1_human Human No 6.9 IC50 = 130 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
413 6 1 2 5.3 CC(C)CC(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3
CHEMBL69978 ccr1_human Human No 6.9 IC50 = 130 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
448 10 3 4 4.5 CC(C)CC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3C=C2)O)C(=O)NC
CHEMBL69123 ccr1_human Human No 6.9 IC50 = 130 Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
495 12 3 6 3.9 CCNC(=O)C(CCC(C)(C)F)CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O
CHEMBL255797 ccr1_human Human No 5.9 IC50 = 1300 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
514 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Br)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL517261 ccr1_human Human No 5.9 IC50 = 1300 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
390 4 1 3 3.4 CN(CC1=CC=C(C=C1)F)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)Cl
CHEMBL255797 ccr1_human Human No 5.9 IC50 = 1300 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
514 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Br)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL517261 ccr1_human Human No 5.9 IC50 = 1300 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
390 4 1 3 3.4 CN(CC1=CC=C(C=C1)F)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)Cl
CHEMBL3099957 ccr1_human Human No 5.9 IC50 = 1300 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
445 5 1 6 4.9 CC1=NC2=C(C=CC=C2S1)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL3099956 ccr1_human Human No 5.9 IC50 = 1300 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
446 5 2 7 4.1 C1CN(CCC12CC3=C(O2)C=CC(=C3)Cl)CC(COC4=C5C(=CC=C4)SC(=N5)N)O
CHEMBL256449 ccr1_human Human No 5.9 IC50 = 1330 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
489 4 1 8 3.7 C1CN(CCC1N2CCC(CC2)(C3=CC(=C(C(=C3)F)F)F)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL256449 ccr1_human Human No 5.9 IC50 = 1330 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
489 4 1 8 3.7 C1CN(CCC1N2CCC(CC2)(C3=CC(=C(C(=C3)F)F)F)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL257698 ccr1_human Human No 5.9 IC50 = 1340 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC(=CC(=C3)Cl)Cl
CHEMBL257698 ccr1_human Human No 5.9 IC50 = 1340 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC(=CC(=C3)Cl)Cl
CHEMBL340491 ccr1_human Human No 5.9 IC50 = 1340 Funct
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
604 10 3 5 7.1 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(CNC(=O)NC3=C(C=CC(=C3)F)F)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL197375 ccr1_human Human No 5.9 IC50 = 1350 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
444 5 1 4 3.9 CC1CN(C(CN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)C)CC3=CC=C(C=C3)F
CHEMBL197375 ccr1_human Human No 5.9 IC50 = 1350 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
444 5 1 4 3.9 CC1CN(C(CN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)C)CC3=CC=C(C=C3)F
CHEMBL232253 ccr1_human Human No 7.9 IC50 = 14 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
545 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Br)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL3679652 ccr1_human Human No 7.9 IC50 = 14 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
463 4 3 4 3.3 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)C4CCC(C4)O)C
CHEMBL232253 ccr1_human Human No 7.9 IC50 = 14 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
545 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Br)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL3679652 ccr1_human Human No 7.9 IC50 = 14 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
463 4 3 4 3.3 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCC3NC(=O)C4CCC(C4)O)C
CHEMBL2322881 ccr1_human Human No 7.9 IC50 = 14 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
530 4 0 7 4.7 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C(=C3)Br)Cl)OC)C(F)(F)F)Cl
CHEMBL2180508 ccr1_human Human No 7.9 IC50 = 14 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
435 5 1 4 5.2 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC(=C(C=C3)F)F
CHEMBL3334824 ccr1_human Human No 7.8 IC50 = 14.3 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 mins
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL3334824 ccr1_human Human No 7.9 IC50 = 14.3 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 mins
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL3679650 ccr1_human Human No 7.8 IC50 = 14.6 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
466 5 4 4 3.2 CC(CNC(=O)NC1CCCCC1C(=O)N2CCC(C(C2)(C)C)(C3=CC=C(C=C3)Cl)O)O
CHEMBL3679650 ccr1_human Human No 7.8 IC50 = 14.6 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
466 5 4 4 3.2 CC(CNC(=O)NC1CCCCC1C(=O)N2CCC(C(C2)(C)C)(C3=CC=C(C=C3)Cl)O)O
CHEMBL514611 ccr1_human Human Yes 6.9 IC50 = 140 Funct
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
440 4 1 5 4.2 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL514611 ccr1_human Human Yes 6.9 IC50 = 140 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
440 4 1 5 4.2 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL232455 ccr1_human Human No 6.9 IC50 = 140 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
502 8 2 10 3.1 CC1CN(CCN1C(=O)COC2=CC(=C(C=C2NC3=C(C(=O)C3=O)NC)F)F)CC4=CC=C(C=C4)F
CHEMBL429591 ccr1_human Human No 6.9 IC50 = 140 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
488 7 2 5 3.8 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3Br
CHEMBL514611 ccr1_human Human Yes 6.9 IC50 = 140 Funct
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
440 4 1 5 4.2 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL514611 ccr1_human Human Yes 6.9 IC50 = 140 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
440 4 1 5 4.2 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL2180189 ccr1_human Human No 6.9 IC50 = 140 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
427 6 1 2 5.3 CC1=CC=C(C=C1)CC(=O)NC(C(C)C)C(=O)N2CCC(CC2)C3=CC=C(C=C3)Cl
CHEMBL232455 ccr1_human Human No 6.9 IC50 = 140 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
502 8 2 10 3.1 CC1CN(CCN1C(=O)COC2=CC(=C(C=C2NC3=C(C(=O)C3=O)NC)F)F)CC4=CC=C(C=C4)F
CHEMBL429591 ccr1_human Human No 6.9 IC50 = 140 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
488 7 2 5 3.8 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3Br
CHEMBL33074 ccr1_human Human No 6.9 IC50 = 140 Funct
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
433 4 1 3 6.5 C1CCCC(CCC1)CN2CCC(CC2)NC(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL402825 ccr1_human Human No 5.9 IC50 = 1400 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
514 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Br)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL402825 ccr1_human Human No 5.9 IC50 = 1400 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
514 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Br)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL402825 ccr1_human Human No 5.9 IC50 = 1400 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
514 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Br)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL402825 ccr1_human Human No 5.9 IC50 = 1400 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
514 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Br)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL2391804 q9jly8_rat Rat No 4.9 IC50 = 14000 Funct
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
503 6 3 7 2.6 C1CN(CC1O)C(=O)C2=C(C=C(C=C2)O)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL2391796 q9jly8_rat Rat No 4.9 IC50 = 14000 Funct
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
503 6 3 7 2.6 C1CN(CC1O)C(=O)C2=C(C=C(C=C2)O)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL338624 ccr1_human Human No 5.9 IC50 = 1410 Funct
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
636 10 3 6 7.8 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(CNC(=O)NC3=CC=CC(=C3)C(F)(F)F)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2180523 ccr1_human Human No 4.8 IC50 = 14930 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
399 5 1 2 5.0 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3
CHEMBL428193 ccr1_human Human No 7.8 IC50 = 15 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
578 10 2 9 3.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCC4=CC=CC=N4)CC5=CC=C(C=C5)F
CHEMBL2180528 ccr1_human Human No 7.8 IC50 = 15 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPRAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPR
399 5 1 2 5.0 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3
CHEMBL2322875 ccr1_human Human No 7.8 IC50 = 15 Funct
Antagonist activity at CCR1 in human monocytes assessed as inhibition of CCL15/Leukotactin1-induced chemotaxisAntagonist activity at CCR1 in human monocytes assessed as inhibition of CCL15/Leukotactin1-induced chemotaxis
451 4 0 7 4.0 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C(F)(F)F)Cl
CHEMBL2398740 ccr1_human Human No 7.8 IC50 = 15 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
381 4 2 3 3.0 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C
CHEMBL2398734 ccr1_human Human No 7.8 IC50 = 15 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
444 5 2 4 4.0 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=CC=N3
CHEMBL428193 ccr1_human Human No 7.8 IC50 = 15 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
578 10 2 9 3.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCC4=CC=CC=N4)CC5=CC=C(C=C5)F
CHEMBL69659 ccr1_human Human No 7.8 IC50 = 15 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
491 9 3 6 2.9 CC1CC(CC(O1)C)C(CC(C(CC2=CC=CC=C2)NC(=O)C3=NC4=CC=CC=C4N=C3)O)C(=O)N
CHEMBL3679646 ccr1_human Human No 7.8 IC50 = 15.7 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
497 6 2 3 5.5 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCCC3NC(=O)CCC4=CC=CC=C4)C
CHEMBL3679646 ccr1_human Human No 7.8 IC50 = 15.7 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
497 6 2 3 5.5 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCCC3NC(=O)CCC4=CC=CC=C4)C
CHEMBL200680 ccr1_human Human No 6.8 IC50 = 150 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
459 5 1 5 3.3 CC(=O)NC1=C(C=C2C=CC=NC2=C1)C=CC(=O)N3C4CCC3CN(C4)CC5=CC=C(C=C5)F
CHEMBL198852 ccr1_human Human No 6.8 IC50 = 150 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
416 5 1 4 3.0 CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2CCN(CC2)CC3=CC=C(C=C3)F
CHEMBL256404 ccr1_human Human No 6.8 IC50 = 150 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
423 7 2 5 3.4 CC1=CC=CC=C1S(=O)(=O)NCCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O
CHEMBL200680 ccr1_human Human No 6.8 IC50 = 150 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
459 5 1 5 3.3 CC(=O)NC1=C(C=C2C=CC=NC2=C1)C=CC(=O)N3C4CCC3CN(C4)CC5=CC=C(C=C5)F
CHEMBL198852 ccr1_human Human No 6.8 IC50 = 150 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
416 5 1 4 3.0 CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2CCN(CC2)CC3=CC=C(C=C3)F
CHEMBL256404 ccr1_human Human No 6.8 IC50 = 150 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
423 7 2 5 3.4 CC1=CC=CC=C1S(=O)(=O)NCCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O
CHEMBL33580 ccr1_human Human No 6.8 IC50 = 150 Funct
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
588 4 1 3 7.1 C1CCCC(=CCC1)CN2CCC(CC2)NC(=O)C3C4=C(C=CC(=C4)Br)OC5=C3C=C(C=C5)Br
CHEMBL370596 ccr1_human Human No 5.8 IC50 = 1500 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
446 5 1 4 4.1 CC1CN(CCN1C(=O)C=CC2=CC3=CC=CC=C3C=C2NC(=O)C)CC4=CC=C(C=C4)F
CHEMBL370596 ccr1_human Human No 5.8 IC50 = 1500 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
446 5 1 4 4.1 CC1CN(CCN1C(=O)C=CC2=CC3=CC=CC=C3C=C2NC(=O)C)CC4=CC=C(C=C4)F
CHEMBL69822 ccr1_human Human No 4.8 IC50 = 15000 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
454 10 3 4 5.3 CC(C)CC(CC(C(CC1CCCCC1)NC(=O)C2=CC3=CC=CC=C3N=C2)O)C(=O)NC
CHEMBL2180524 ccr1_human Human No 6.8 IC50 = 152 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
365 6 1 2 4.1 CCC(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)CC(C)C
CHEMBL2180541 ccr1_human Human No 6.8 IC50 = 152 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
413 6 1 2 5.2 CCCC(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3C
CHEMBL2398764 ccr1_human Human No 6.8 IC50 = 153 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
533 7 3 3 5.2 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC(=C3)C4=CC=CC=C4NC(=O)N
CHEMBL3099948 q9jly8_rat Rat No 5.8 IC50 = 1580 Funct
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
448 6 4 6 2.3 C1CN(CCC12CC3=C(O2)C=CC(=C3)Cl)CC(COC4=C(C=CC(=C4)O)NC(=O)N)O
CHEMBL1224118 ccr1_human Human No 7.8 IC50 = 16 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
449 4 1 5 4.4 C1CC(N(C1)C(=O)NC2=CC=C(C=C2)C(F)(F)F)C3=NC=CN3CC4=CC=C(C=C4)Cl
CHEMBL473734 ccr1_human Human No 7.8 IC50 = 16 Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
454 4 1 5 4.5 CC1=C(C=CC(=C1)C(F)(F)F)NC(=O)N2CCCC2C(=O)N(C)CC3=CC=C(C=C3)Cl
CHEMBL196860 ccr1_human Human No 7.8 IC50 = 16 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
431 5 2 4 2.9 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL1224118 ccr1_human Human No 7.8 IC50 = 16 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
449 4 1 5 4.4 C1CC(N(C1)C(=O)NC2=CC=C(C=C2)C(F)(F)F)C3=NC=CN3CC4=CC=C(C=C4)Cl
CHEMBL473734 ccr1_human Human No 7.8 IC50 = 16 Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
454 4 1 5 4.5 CC1=C(C=CC(=C1)C(F)(F)F)NC(=O)N2CCCC2C(=O)N(C)CC3=CC=C(C=C3)Cl
CHEMBL196860 ccr1_human Human No 7.8 IC50 = 16 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
431 5 2 4 2.9 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL2322887 ccr1_human Human No 7.8 IC50 = 16 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
480 5 1 8 2.9 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C(=C3)CN)Cl)OC)C(F)(F)F)Cl
CHEMBL2322845 ccr1_human Human No 7.8 IC50 = 16 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
441 5 1 5 2.8 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C(C)(C)O)Cl
CHEMBL3099943 q9jly8_rat Rat No 7.8 IC50 = 16 Funct
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
522 7 4 6 3.8 C1CC1NC(=O)NC2=CC(=C(C=C2OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O)O)Cl
CHEMBL3334824 ccr1_human Human No 7.8 IC50 = 16.2 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 mins
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL3334824 ccr1_human Human No 7.8 IC50 = 16.2 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 mins
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL387821 ccr1_human Human No 6.8 IC50 = 160 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
558 11 2 9 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN(C)C)CC4=CC=C(C=C4)F
CHEMBL396700 ccr1_human Human No 6.8 IC50 = 160 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
485 8 2 9 3.0 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)F)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL272097 ccr1_human Human No 6.8 IC50 = 160 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
415 7 2 6 3.1 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CS3
CHEMBL2391793 q9jly8_rat Rat No 6.8 IC50 = 160 Funct
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
447 6 3 6 2.9 CNC(=O)C1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)Cl)O
CHEMBL3099955 ccr1_human Human No 6.8 IC50 = 160 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
428 5 1 5 4.8 CC1=CC2=C(O1)C=CC=C2OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL387821 ccr1_human Human No 6.8 IC50 = 160 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
558 11 2 9 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN(C)C)CC4=CC=C(C=C4)F
CHEMBL396700 ccr1_human Human No 6.8 IC50 = 160 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
485 8 2 9 3.0 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)F)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL272097 ccr1_human Human No 6.8 IC50 = 160 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
415 7 2 6 3.1 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CS3
CHEMBL71242 ccr1_human Human No 6.8 IC50 = 160 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
517 10 3 5 4.8 CC(C)CC(CC(C(CC1=CC(=C(C=C1)Cl)Cl)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)NC
CHEMBL370447 ccr1_human Human No 5.8 IC50 = 1600 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
444 5 1 4 3.8 CC1CN(CCCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL370447 ccr1_human Human No 5.8 IC50 = 1600 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
444 5 1 4 3.8 CC1CN(CCCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL142199 ccr1_human Human No 5.8 IC50 = 1600 Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
459 8 1 3 6.0 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCCC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL33159 ccr1_human Human No 5.8 IC50 = 1600 Funct
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
435 6 2 3 6.1 C1CCCC(CCC1)CN2CCC(CC2)NC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O
CHEMBL2398720 ccr1_human Human No 5.8 IC50 = 1603 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
450 5 3 4 3.0 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)N
CHEMBL3099950 q9jly8_rat Rat No 5.8 IC50 = 1620 Funct
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
450 6 3 6 2.7 C1CN(CCC12CC3=C(O2)C=CC(=C3)Cl)CC(COC4=C(C=CC(=C4)F)NC(=O)N)O
CHEMBL256264 ccr1_human Human No 5.8 IC50 = 1650 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
423 6 2 3 4.6 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNC(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL256264 ccr1_human Human No 5.8 IC50 = 1650 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
423 6 2 3 4.6 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNC(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL332277 ccr1_human Human No 6.8 IC50 = 167 Funct
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
569 10 3 4 5.8 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(CNC(=O)NC3=CC=NC=C3)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL387608 ccr1_mouse Mouse No 5.8 IC50 = 1670 Funct
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
599 11 3 10 2.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCNCC4)CC5=CC=C(C=C5)F
CHEMBL387608 ccr1_mouse Mouse No 5.8 IC50 = 1670 Funct
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
599 11 3 10 2.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCNCC4)CC5=CC=C(C=C5)F
CHEMBL305420 ccr1_human Human No 4.8 IC50 = 16700 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
464 10 4 4 4.1 CC(C)CC(CC(C(CC1=CC=CC=C1)NC(=O)C2=CC3=CC=CC=C3NC2=O)O)C(=O)NC
CHEMBL231829 ccr1_human Human No 7.8 IC50 = 17 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
501 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL232837 q9jly8_rat Rat No 7.8 IC50 = 17 Funct
Binding affinity at rat CCR1Binding affinity at rat CCR1
530 10 3 9 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN)CC4=CC=C(C=C4)F
CHEMBL1224188 ccr1_human Human No 7.8 IC50 = 17 Funct
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
450 4 1 6 3.8 C1CC(N(C1)C(=O)NC2=CC=C(C=C2)C(F)(F)F)C3=NN=CN3CC4=CC=C(C=C4)Cl
CHEMBL231829 ccr1_human Human No 7.8 IC50 = 17 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
501 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL232837 q9jly8_rat Rat No 7.8 IC50 = 17 Funct
Binding affinity at rat CCR1Binding affinity at rat CCR1
530 10 3 9 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN)CC4=CC=C(C=C4)F
CHEMBL2398725 ccr1_human Human No 7.8 IC50 = 17 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
450 5 3 4 3.5 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCCC3N
CHEMBL1224188 ccr1_human Human No 7.8 IC50 = 17 Funct
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
450 4 1 6 3.8 C1CC(N(C1)C(=O)NC2=CC=C(C=C2)C(F)(F)F)C3=NN=CN3CC4=CC=C(C=C4)Cl
CHEMBL3679641 ccr1_human Human No 7.8 IC50 = 17.2 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
483 4 2 4 3.7 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CC(=O)CCC3NC(=O)C4=CC=CC=C4)C
CHEMBL3679641 ccr1_human Human No 7.8 IC50 = 17.2 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
483 4 2 4 3.7 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CC(=O)CCC3NC(=O)C4=CC=CC=C4)C
CHEMBL234081 ccr1_human Human No 6.8 IC50 = 170 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
529 10 2 8 4.4 CCCNC1=C(C(=O)C1=O)NC2=C(C=CC(=C2)Cl)OCC(=O)N3CCN(CC3C)CC4=CC=C(C=C4)F
CHEMBL234081 ccr1_human Human No 6.8 IC50 = 170 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
529 10 2 8 4.4 CCCNC1=C(C(=O)C1=O)NC2=C(C=CC(=C2)Cl)OCC(=O)N3CCN(CC3C)CC4=CC=C(C=C4)F
CHEMBL196908 ccr1_human Human No 5.8 IC50 = 1700 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
428 5 1 4 3.3 CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2CC3CC2CN3CC4=CC=C(C=C4)F
CHEMBL370162 ccr1_human Human No 5.8 IC50 = 1700 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
433 6 2 5 3.1 CC1CN(CCN1C(=O)CNC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL196908 ccr1_human Human No 5.8 IC50 = 1700 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
428 5 1 4 3.3 CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2CC3CC2CN3CC4=CC=C(C=C4)F
CHEMBL370162 ccr1_human Human No 5.8 IC50 = 1700 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
433 6 2 5 3.1 CC1CN(CCN1C(=O)CNC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL2180531 ccr1_human Human No 6.8 IC50 = 172 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
459 5 2 3 3.9 CC(C)C(C(=O)N1CCC(CC1)(C2=CC=C(C=C2)Br)O)NC(=O)C3=CC=CC=C3
CHEMBL3099942 q9jly8_rat Rat No 5.8 IC50 = 1760 Funct
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
462 6 4 6 2.7 CNC(=O)NC1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)Cl)O
CHEMBL2180512 ccr1_human Human No 6.8 IC50 = 177 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
427 5 1 2 5.7 CC1=C(C(=CC=C1)C)C(=O)NC(C(C)C)C(=O)N2CCC(CC2)C3=CC=C(C=C3)Cl
CHEMBL234295 ccr1_mouse Mouse No 5.8 IC50 = 1770 Funct
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
600 11 2 10 3.1 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCOCC4)CC5=CC=C(C=C5)F
CHEMBL234295 ccr1_mouse Mouse No 5.8 IC50 = 1770 Funct
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
600 11 2 10 3.1 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCOCC4)CC5=CC=C(C=C5)F
CHEMBL3099960 q9jly8_rat Rat No 5.8 IC50 = 1780 Funct
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
460 7 3 7 2.5 CNC(=O)NC1=C(C=C(C=C1)OC)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)F)O
CHEMBL232656 ccr1_human Human Yes 7.8 IC50 = 18 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
435 6 2 5 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL232656 ccr1_human Human Yes 7.8 IC50 = 18 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
435 6 2 5 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL231829 ccr1_human Human No 7.8 IC50 = 18 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
501 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL232837 ccr1_human Human No 7.8 IC50 = 18 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
530 10 3 9 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN)CC4=CC=C(C=C4)F
CHEMBL232656 ccr1_human Human Yes 7.8 IC50 = 18 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
435 6 2 5 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL2398758 ccr1_human Human No 7.8 IC50 = 18 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
420 5 1 3 4.8 CC(C)C(C(=O)N1CCN(C(C1)(C)C)C2=CC=C(C=C2)Cl)NC(=O)C3CCCC3
CHEMBL232656 ccr1_human Human Yes 7.8 IC50 = 18 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
435 6 2 5 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL231829 ccr1_human Human No 7.8 IC50 = 18 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
501 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL2398761 ccr1_human Human No 7.8 IC50 = 18 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
443 5 2 3 4.7 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=CC=C3
CHEMBL2322863 ccr1_human Human No 7.8 IC50 = 18 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
437 4 0 7 3.6 COC1=C(C=CC(=C1)N2CCN(CC2)C(=O)CN3C=C(C(=N3)C(F)(F)F)Cl)Cl
CHEMBL2180192 ccr1_human Human No 7.8 IC50 = 18 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
445 7 1 3 5.3 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)CCC3=CC=CC=C3F
CHEMBL2180195 ccr1_human Human No 7.8 IC50 = 18 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
456 5 1 4 5.7 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=NC4=CC=CC=C4S3
CHEMBL2332942 ccr1_human Human No 7.8 IC50 = 18 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
412 6 3 6 2.0 CC(=O)NC1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=CC=CC=C4O3)N
CHEMBL232837 ccr1_human Human No 7.8 IC50 = 18 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
530 10 3 9 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN)CC4=CC=C(C=C4)F
CHEMBL3679642 ccr1_human Human No 7.7 IC50 = 18.5 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
484 4 3 3 5.0 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCCC3NC(=O)NC4=CC=CC=C4)C
CHEMBL3679642 ccr1_human Human No 7.7 IC50 = 18.5 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
484 4 3 3 5.0 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCCC3NC(=O)NC4=CC=CC=C4)C
CHEMBL3679644 ccr1_human Human No 7.7 IC50 = 18.7 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
471 4 2 5 3.6 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCCC3NC(=O)C4=CN=CN=C4)C
CHEMBL3679644 ccr1_human Human No 7.7 IC50 = 18.7 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
471 4 2 5 3.6 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCCC3NC(=O)C4=CN=CN=C4)C
CHEMBL258359 ccr1_human Human No 6.8 IC50 = 180 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
504 4 1 5 4.7 C1CN(CCC1N2CCC(CC2)(C3=CC(=C(C=C3)Cl)Cl)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL271903 ccr1_human Human No 6.8 IC50 = 180 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
514 4 1 5 4.1 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Br)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL270433 ccr1_human Human No 6.8 IC50 = 180 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
459 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC4=CC=CC=C43
CHEMBL404033 ccr1_human Human No 6.8 IC50 = 180 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
449 4 1 5 3.8 CC1=CC=CC=C1S(=O)(=O)N2CCC(CC2)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL258359 ccr1_human Human No 6.8 IC50 = 180 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
504 4 1 5 4.7 C1CN(CCC1N2CCC(CC2)(C3=CC(=C(C=C3)Cl)Cl)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL271903 ccr1_human Human No 6.8 IC50 = 180 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
514 4 1 5 4.1 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Br)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL270433 ccr1_human Human No 6.8 IC50 = 180 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
459 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC4=CC=CC=C43
CHEMBL404033 ccr1_human Human No 6.8 IC50 = 180 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
449 4 1 5 3.8 CC1=CC=CC=C1S(=O)(=O)N2CCC(CC2)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL2180548 ccr1_human Human No 6.8 IC50 = 180 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
415 5 2 3 3.9 CC(C)C(C(=O)N1CCC(CC1)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=CC=C3
CHEMBL2180521 ccr1_human Human No 6.8 IC50 = 180 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
428 6 2 2 4.6 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)NCC3=CC=CC=C3
CHEMBL2398751 ccr1_human Human No 5.8 IC50 = 1800 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
477 5 2 3 5.3 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=C(C=C3)Cl
CHEMBL2322891 ccr1_human Human No 6.7 IC50 = 182 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
466 3 0 6 4.1 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC=C(C=C3)Br)C(F)(F)F)Cl
CHEMBL2180532 ccr1_human Human No 6.7 IC50 = 185 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
397 5 1 2 4.6 CC(C)C(C(=O)N1CCC(=CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3
CHEMBL411476 ccr1_human Human No 5.7 IC50 = 1850 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC(=C(C=C3)Cl)Cl
CHEMBL411476 ccr1_human Human No 5.7 IC50 = 1850 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC(=C(C=C3)Cl)Cl
CHEMBL303947 ccr1_human Human No 4.7 IC50 = 18500 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
448 10 3 4 4.2 CC(C)CC(CC(C(CC1=CC=CC=C1)NC(=O)C2=CC=NC3=CC=CC=C23)O)C(=O)NC
CHEMBL3334726 ccr1_human Human No 7.7 IC50 = 19 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL387822 ccr1_human Human No 7.7 IC50 = 19 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
545 11 2 9 3.3 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCOC)CC4=CC=C(C=C4)F
CHEMBL3334726 ccr1_human Human No 7.7 IC50 = 19 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL387822 ccr1_human Human No 7.7 IC50 = 19 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
545 11 2 9 3.3 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCOC)CC4=CC=C(C=C4)F
CHEMBL2322857 ccr1_human Human No 7.7 IC50 = 19 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
417 4 0 7 3.4 CC1=CC(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C(F)(F)F
CHEMBL2180190 ccr1_human Human No 7.7 IC50 = 19 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
441 7 1 2 5.6 CC1=CC=CC=C1CCC(=O)NC(C(C)C)C(=O)N2CCC(CC2)C3=CC=C(C=C3)Cl
CHEMBL258361 ccr1_human Human No 6.7 IC50 = 190 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
493 8 2 9 4.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3OC(F)(F)F
CHEMBL198852 ccr1_human Human No 6.7 IC50 = 190 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
416 5 1 4 3.0 CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2CCN(CC2)CC3=CC=C(C=C3)F
CHEMBL258361 ccr1_human Human No 6.7 IC50 = 190 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
493 8 2 9 4.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3OC(F)(F)F
CHEMBL198852 ccr1_human Human No 6.7 IC50 = 190 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
416 5 1 4 3.0 CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2CCN(CC2)CC3=CC=C(C=C3)F
CHEMBL272758 ccr1_human Human No 5.7 IC50 = 1900 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
469 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL20921 ccr1_human Human Yes 5.7 IC50 = 1900 Funct
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
481 6 2 6 5.2 C1CN(CCC1NC(=O)CSC2=NC3=C(S2)C=C(C=C3)N)CC4=CC(=C(C=C4)Cl)Cl
CHEMBL272758 ccr1_human Human No 5.7 IC50 = 1900 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
469 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL142468 ccr1_human Human No 5.7 IC50 = 1900 Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
478 7 1 4 4.8 COC1=C(C=C(C=C1)C(CCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O)C#N)Br
CHEMBL33639 ccr1_mouse Mouse No 5.7 IC50 = 1900 Funct
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
499 4 1 3 7.0 C1CCCC(=CCC1)CN2CCC(CC2)NC(=O)C3C4=C(C=CC(=C4)Cl)OC5=C3C=C(C=C5)Cl
CHEMBL2180545 ccr1_human Human No 6.7 IC50 = 191 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
449 6 1 2 6.1 CCCC(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL2398721 ccr1_human Human No 6.7 IC50 = 194 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
450 5 3 4 3.0 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)N
CHEMBL2398753 ccr1_human Human No 6.7 IC50 = 196 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
476 5 2 3 5.1 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)N)NC(=O)C3=CC=C(C=C3)Cl
CHEMBL427834 ccr1_human Human No 5.7 IC50 = 1980 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
469 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL427834 ccr1_human Human No 5.7 IC50 = 1980 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
469 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL3334817 ccr1_human Human No 8.7 IC50 = 2 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
438 6 3 3 4.2 CCC(C)NC(=O)NC(C(C)C)C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O
CHEMBL3334817 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
438 6 3 3 4.2 CCC(C)NC(=O)NC(C(C)C)C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O
CHEMBL3334822 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
425 6 3 4 2.7 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CC(C)O
CHEMBL3334825 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
453 7 3 4 3.3 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CCC(C)(C)O
CHEMBL3334821 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
440 6 4 4 2.6 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)O
CHEMBL3334728 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL3334725 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
450 5 3 3 4.1 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCCC3
CHEMBL3334823 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
440 6 4 4 2.6 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)O
CHEMBL304358 ccr1_human Human No 8.7 IC50 = 2 Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
449 11 3 5 3.7 CC(C)CCC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)N
CHEMBL3334817 ccr1_human Human No 8.7 IC50 = 2 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
438 6 3 3 4.2 CCC(C)NC(=O)NC(C(C)C)C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O
CHEMBL2332935 ccr1_human Human No 8.7 IC50 = 2 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
447 6 3 6 2.8 CC(=O)NC1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)Cl)O
CHEMBL2322853 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
465 4 0 7 4.4 CC1CN(CCN1C(=O)CN2C(=C(C(=N2)C(F)(F)F)Cl)C)C3=CC(=C(C=C3)Cl)OC
CHEMBL3334817 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
438 6 3 3 4.2 CCC(C)NC(=O)NC(C(C)C)C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O
CHEMBL3334822 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
425 6 3 4 2.7 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CC(C)O
CHEMBL3334825 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
453 7 3 4 3.3 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CCC(C)(C)O
CHEMBL3334821 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
440 6 4 4 2.6 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)O
CHEMBL3334728 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL3334725 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
450 5 3 3 4.1 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCCC3
CHEMBL3334823 ccr1_human Human No 8.7 IC50 = 2 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
440 6 4 4 2.6 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)O
CHEMBL304358 ccr1_human Human No 8.7 IC50 = 2 Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
449 11 3 5 3.7 CC(C)CCC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)N
CHEMBL3679637 ccr1_human Human No 8.7 IC50 = 2.1 Funct
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
469 4 2 3 5.3 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCCC3NC(=O)C4=CC=CC=C4)C
CHEMBL2398726 ccr1_human Human No 8.7 IC50 = 2.1 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
451 5 3 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)O
CHEMBL3679637 ccr1_human Human No 8.7 IC50 = 2.1 Funct
BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).BindingDB_Patents: Scintillation Proximity Assay (SPA). CCR1 ligand binding using scintillation proximity assay (SPA).
469 4 2 3 5.3 CC1(CN(CCC1(C2=CC=C(C=C2)Cl)O)C(=O)C3CCCCC3NC(=O)C4=CC=CC=C4)C
CHEMBL2398748 ccr1_human Human No 8.7 IC50 = 2.2 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
449 5 2 3 5.1 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCCCC3
CHEMBL2398724 ccr1_human Human No 8.7 IC50 = 2.2 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
450 5 3 4 3.5 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCCC3N
CHEMBL3099946 ccr1_human Human No 8.7 IC50 = 2.2 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
486 8 3 7 3.0 COC1=CC(=C(C=C1)NC(=O)NC2CC2)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)F)O
CHEMBL2398722 ccr1_human Human No 8.6 IC50 = 2.3 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
451 5 3 4 3.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCCC3O
CHEMBL2398750 ccr1_human Human No 8.6 IC50 = 2.3 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
564 8 3 6 3.6 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCCC3(CCN4CCOCC4)O
CHEMBL370162 ccr1_human Human No 8.6 IC50 = 2.4 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
433 6 2 5 3.1 CC1CN(CCN1C(=O)CNC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL370162 ccr1_human Human No 8.6 IC50 = 2.4 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
433 6 2 5 3.1 CC1CN(CCN1C(=O)CNC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL2322875 ccr1_human Human No 8.6 IC50 = 2.5 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL23/CKbeta8.1-induced chemotaxisAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL23/CKbeta8.1-induced chemotaxis
451 4 0 7 4.0 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C(F)(F)F)Cl
CHEMBL2391800 ccr1_human Human No 8.6 IC50 = 2.5 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
505 6 2 7 3.1 C1CN(CC1O)C(=O)C2=C(C=C(C=C2)F)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL2391938 ccr1_human Human No 8.6 IC50 = 2.5 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
487 8 2 6 3.8 COC1=CC(=C(C=C1)C(=O)NC2CC2)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL2398747 ccr1_human Human No 8.6 IC50 = 2.5 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
435 5 2 3 4.6 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCCC3
CHEMBL2332936 ccr1_human Human No 8.6 IC50 = 2.6 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
430 6 3 7 2.3 CC(=O)NC1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)F)O
CHEMBL2398749 ccr1_human Human No 8.6 IC50 = 2.6 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
515 6 2 3 6.4 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CC34CC5CC(C3)CC(C5)C4
CHEMBL2398726 ccr1_human Human No 8.6 IC50 = 2.7 Funct
Antagonist activity at human CCR1 assessed as inhibition of MPIF-1-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MPIF-1-induced chemotaxis
451 5 3 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)O
CHEMBL2391937 ccr1_human Human No 8.6 IC50 = 2.8 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
457 7 2 5 3.8 C1CC1NC(=O)C2=CC=CC=C2OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL1224189 ccr1_human Human No 8.5 IC50 = 2.9 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
464 4 1 6 4.2 CC1=NN=C(N1CC2=CC=C(C=C2)Cl)C3CCCN3C(=O)NC4=CC=C(C=C4)C(F)(F)F
CHEMBL1224189 ccr1_human Human No 8.5 IC50 = 2.9 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
464 4 1 6 4.2 CC1=NN=C(N1CC2=CC=C(C=C2)Cl)C3CCCN3C(=O)NC4=CC=C(C=C4)C(F)(F)F
CHEMBL2398729 ccr1_human Human No 8.5 IC50 = 2.9 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
451 5 3 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)O
CHEMBL2398763 ccr1_human Human No 8.5 IC50 = 2.9 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
477 5 3 5 4.5 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC(=C(C=C3)F)O
CHEMBL2398743 ccr1_human Human No 8.5 IC50 = 2.9 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
423 6 2 3 4.3 CC(C)CC(=O)NC(C(C)C)C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O
CHEMBL199412 ccr1_human Human No 7.7 IC50 = 20 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
447 5 1 5 3.1 CC1CN(CCN1C(=O)C=CC2=C(C=C3C(=C2)C=CC=N3)NC(=O)C)CC4=CC=C(C=C4)F
CHEMBL200629 ccr1_human Human No 7.7 IC50 = 20 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
460 6 1 5 3.4 CC1CN(CCN1C(=O)C=CC2=CC(=C(C=C2NC(=O)C)Cl)OC)CC3=CC=C(C=C3)F
CHEMBL232441 q9jly8_rat Rat No 7.7 IC50 = 20 Funct
Binding affinity at rat CCR1Binding affinity at rat CCR1
487 7 2 8 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)N)CC4=CC=C(C=C4)F
CHEMBL1224119 ccr1_human Human No 7.7 IC50 = 20 Funct
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
451 4 1 7 3.9 C1CC(N(C1)C(=O)NC2=CC=C(C=C2)C(F)(F)F)C3=NN=NN3CC4=CC=C(C=C4)Cl
CHEMBL3334724 ccr1_human Human No 7.7 IC50 = 20 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
458 5 3 3 4.4 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3=CC=CC=C3
CHEMBL232638 ccr1_human Human No 7.7 IC50 = 20 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
531 10 3 9 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCO)CC4=CC=C(C=C4)F
CHEMBL199412 ccr1_human Human No 7.7 IC50 = 20 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
447 5 1 5 3.1 CC1CN(CCN1C(=O)C=CC2=C(C=C3C(=C2)C=CC=N3)NC(=O)C)CC4=CC=C(C=C4)F
CHEMBL200629 ccr1_human Human No 7.7 IC50 = 20 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
460 6 1 5 3.4 CC1CN(CCN1C(=O)C=CC2=CC(=C(C=C2NC(=O)C)Cl)OC)CC3=CC=C(C=C3)F
CHEMBL232441 q9jly8_rat Rat No 7.7 IC50 = 20 Funct
Binding affinity at rat CCR1Binding affinity at rat CCR1
487 7 2 8 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)N)CC4=CC=C(C=C4)F
CHEMBL2398723 ccr1_human Human No 7.7 IC50 = 20 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
451 5 3 4 3.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCCC3O
CHEMBL2322846 ccr1_human Human No 7.7 IC50 = 20 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
462 4 0 4 4.1 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)Br)Cl
CHEMBL1224119 ccr1_human Human No 7.7 IC50 = 20 Funct
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
451 4 1 7 3.9 C1CC(N(C1)C(=O)NC2=CC=C(C=C2)C(F)(F)F)C3=NN=NN3CC4=CC=C(C=C4)Cl
CHEMBL2180504 ccr1_human Human No 7.7 IC50 = 20 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
405 6 1 2 5.4 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)CC3CCCC3
CHEMBL3334724 ccr1_human Human No 7.7 IC50 = 20 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
458 5 3 3 4.4 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3=CC=CC=C3
CHEMBL232638 ccr1_human Human No 7.7 IC50 = 20 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
531 10 3 9 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCO)CC4=CC=C(C=C4)F
CHEMBL302533 ccr1_human Human No 7.7 IC50 = 20 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
497 9 3 7 3.6 C1CC(CCC1C(CC(C(CC2=CC=CC=C2)NC(=O)C3=NC4=CC=CC=C4N=C3)O)C(=O)N)(F)F
CHEMBL380568 ccr1_human Human No 6.7 IC50 = 200 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
442 5 1 4 3.6 CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F
CHEMBL390707 ccr1_human Human No 6.7 IC50 = 200 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
503 8 2 7 3.6 CNC1=C(C(=O)C1=O)NC2=C(C=CC(=C2)Cl)OCC(=O)N3CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL270253 ccr1_human Human No 6.7 IC50 = 200 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
469 4 1 5 4.1 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL380568 ccr1_human Human No 6.7 IC50 = 200 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
442 5 1 4 3.6 CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F
CHEMBL390707 ccr1_human Human No 6.7 IC50 = 200 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
503 8 2 7 3.6 CNC1=C(C(=O)C1=O)NC2=C(C=CC(=C2)Cl)OCC(=O)N3CCN(CC3)CC4=CC=C(C=C4)Cl
CHEMBL270253 ccr1_human Human No 6.7 IC50 = 200 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
469 4 1 5 4.1 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL34053 ccr1_human Human No 6.7 IC50 = 200 Funct
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
405 4 1 3 4.9 C1CCC(CC1)CN2CCC(CC2)NC(=O)C3C4=CC=CC=C4OC5=CC=CC=C35
CHEMBL272758 ccr1_human Human No 5.7 IC50 = 2040 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
469 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL272758 ccr1_human Human No 5.7 IC50 = 2040 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
469 4 1 5 4.1 C1CC(CN(C1)S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL2398759 ccr1_human Human No 6.7 IC50 = 208 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
503 5 2 3 5.8 CC(C)C(C(=O)N1CCC(C2(C1)CCCC2)(C3=CC=C(C=C3)Cl)O)NC(=O)C4=CC=C(C=C4)Cl
CHEMBL232638 q9jly8_rat Rat No 7.7 IC50 = 21 Funct
Binding affinity at rat CCR1Binding affinity at rat CCR1
531 10 3 9 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCO)CC4=CC=C(C=C4)F
CHEMBL2398718 ccr1_human Human No 7.7 IC50 = 21 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
442 5 2 4 3.1 CC(C)C(C(=O)N1CCC(C2(C1)CC2)(C3=CC=C(C=C3)Cl)O)NC(=O)C4=CN=CC=C4
CHEMBL232638 q9jly8_rat Rat No 7.7 IC50 = 21 Funct
Binding affinity at rat CCR1Binding affinity at rat CCR1
531 10 3 9 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCO)CC4=CC=C(C=C4)F
CHEMBL256889 ccr1_human Human No 6.7 IC50 = 210 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
427 7 2 6 3.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=C(C=C3)F
CHEMBL256889 ccr1_human Human No 6.7 IC50 = 210 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
427 7 2 6 3.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=C(C=C3)F
CHEMBL2322884 ccr1_human Human No 6.7 IC50 = 210 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
508 5 1 8 3.3 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C(=C3)C(=O)NC)Cl)OC)C(F)(F)F)Cl
CHEMBL3099949 q9jly8_rat Rat No 5.7 IC50 = 2110 Funct
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
432 6 3 5 2.6 C1CN(CCC12CC3=C(O2)C=CC(=C3)Cl)CC(COC4=CC=CC=C4NC(=O)N)O
CHEMBL1224120 ccr1_human Human No 7.7 IC50 = 22 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
450 4 1 6 4.4 C1CC(N(C1)C(=O)NC2=CC=C(C=C2)C(F)(F)F)C3=NC=NN3CC4=CC=C(C=C4)Cl
CHEMBL514611 ccr1_human Human Yes 7.7 IC50 = 22 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
440 4 1 5 4.2 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL3334825 ccr1_human Human No 7.7 IC50 = 22 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
453 7 3 4 3.3 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CCC(C)(C)O
CHEMBL473532 ccr1_human Human No 7.7 IC50 = 22 Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
458 4 1 6 4.3 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=C(C=C(C=C3)C(F)(F)F)F
CHEMBL514611 ccr1_human Human Yes 7.7 IC50 = 22 Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
440 4 1 5 4.2 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL1224120 ccr1_human Human No 7.7 IC50 = 22 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
450 4 1 6 4.4 C1CC(N(C1)C(=O)NC2=CC=C(C=C2)C(F)(F)F)C3=NC=NN3CC4=CC=C(C=C4)Cl
CHEMBL514611 ccr1_human Human Yes 7.7 IC50 = 22 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
440 4 1 5 4.2 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL3334825 ccr1_human Human No 7.7 IC50 = 22 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
453 7 3 4 3.3 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CCC(C)(C)O
CHEMBL473532 ccr1_human Human No 7.7 IC50 = 22 Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
458 4 1 6 4.3 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=C(C=C(C=C3)C(F)(F)F)F
CHEMBL514611 ccr1_human Human Yes 7.7 IC50 = 22 Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
440 4 1 5 4.2 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)C(F)(F)F
CHEMBL2180191 ccr1_human Human No 7.7 IC50 = 22 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
441 7 1 2 5.6 CC1=CC(=CC=C1)CCC(=O)NC(C(C)C)C(=O)N2CCC(CC2)C3=CC=C(C=C3)Cl
CHEMBL304845 ccr1_human Human No 7.7 IC50 = 22 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
463 11 3 5 4.1 CC(C)CCC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)NC
CHEMBL234276 ccr1_human Human No 6.7 IC50 = 220 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
523 8 2 8 4.1 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=C(S4)Cl
CHEMBL256272 ccr1_human Human No 6.7 IC50 = 220 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
528 4 1 5 4.6 CC1CC(CCN1S(=O)(=O)C2=CC=CC=C2Br)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL2322885 ccr1_human Human No 6.7 IC50 = 220 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
522 5 0 8 3.5 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C(=C3)C(=O)N(C)C)Cl)OC)C(F)(F)F)Cl
CHEMBL234276 ccr1_human Human No 6.7 IC50 = 220 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
523 8 2 8 4.1 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=C(S4)Cl
CHEMBL256272 ccr1_human Human No 6.7 IC50 = 220 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
528 4 1 5 4.6 CC1CC(CCN1S(=O)(=O)C2=CC=CC=C2Br)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL302533 ccr1_human Human No 6.7 IC50 = 220 Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
497 9 3 7 3.6 C1CC(CCC1C(CC(C(CC2=CC=CC=C2)NC(=O)C3=NC4=CC=CC=C4N=C3)O)C(=O)N)(F)F
CHEMBL258363 ccr1_human Human No 5.7 IC50 = 2200 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
477 7 2 8 3.9 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL258363 ccr1_human Human No 5.7 IC50 = 2200 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
477 7 2 8 3.9 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=C(C=C3)C(F)(F)F
CHEMBL2398760 ccr1_human Human No 5.7 IC50 = 2240 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
429 6 2 3 5.2 CC(C)C(CN1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=CC=C3
CHEMBL403665 ccr1_human Human No 5.7 IC50 = 2260 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
483 4 1 5 4.3 CC1(CCN(CC1)S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL402327 ccr1_human Human No 5.7 IC50 = 2260 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
497 4 1 5 4.6 CC1=C(C(=CC=C1)Cl)S(=O)(=O)N2CCC(CC2)(C)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL403665 ccr1_human Human No 5.7 IC50 = 2260 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
483 4 1 5 4.3 CC1(CCN(CC1)S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL402327 ccr1_human Human No 5.7 IC50 = 2260 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
497 4 1 5 4.6 CC1=C(C(=CC=C1)Cl)S(=O)(=O)N2CCC(CC2)(C)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL68937 ccr1_human Human No 5.6 IC50 = 2280 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
454 10 3 4 5.3 CC(C)CC(CC(C(CC1CCCCC1)NC(=O)C2=CC3=CC=CC=C3N=C2)O)C(=O)NC
CHEMBL232837 ccr1_human Human No 7.6 IC50 = 23 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
530 10 3 9 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN)CC4=CC=C(C=C4)F
CHEMBL430166 ccr1_human Human Yes 7.6 IC50 = 23 Funct
Binding Affinity at CCL3Binding Affinity at CCL3
485 6 1 6 0.6 CC1C[NH+](C(CN1C(=O)COC2=C(C=C(C=C2)Cl)CS(=O)(=O)[O-])C)CC3=CC=C(C=C3)F
CHEMBL473532 ccr1_human Human No 7.6 IC50 = 23 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
458 4 1 6 4.3 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=C(C=C(C=C3)C(F)(F)F)F
CHEMBL232837 ccr1_human Human No 7.6 IC50 = 23 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
530 10 3 9 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN)CC4=CC=C(C=C4)F
CHEMBL430166 ccr1_human Human Yes 7.6 IC50 = 23 Funct
Binding Affinity at CCL3Binding Affinity at CCL3
485 6 1 6 0.6 CC1C[NH+](C(CN1C(=O)COC2=C(C=C(C=C2)Cl)CS(=O)(=O)[O-])C)CC3=CC=C(C=C3)F
CHEMBL2322856 ccr1_human Human No 7.6 IC50 = 23 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
465 4 0 7 4.4 CC1CN(CCN1C2=CC(=C(C=C2)Cl)OC)C(=O)CN3C(=C(C(=N3)C(F)(F)F)Cl)C
CHEMBL473532 ccr1_human Human No 7.6 IC50 = 23 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
458 4 1 6 4.3 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=C(C=C(C=C3)C(F)(F)F)F
CHEMBL257452 ccr1_human Human No 6.6 IC50 = 230 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
491 8 2 6 4.4 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3C4=CC=CS4
CHEMBL257452 ccr1_human Human No 6.6 IC50 = 230 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
491 8 2 6 4.4 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3C4=CC=CS4
CHEMBL68937 ccr1_human Human No 5.6 IC50 = 2300 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
454 10 3 4 5.3 CC(C)CC(CC(C(CC1CCCCC1)NC(=O)C2=CC3=CC=CC=C3N=C2)O)C(=O)NC
CHEMBL68937 ccr1_human Human No 5.6 IC50 = 2300 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
454 10 3 4 5.3 CC(C)CC(CC(C(CC1CCCCC1)NC(=O)C2=CC3=CC=CC=C3N=C2)O)C(=O)NC
CHEMBL197345 ccr1_mouse Mouse No 4.6 IC50 = 23000 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
444 5 1 4 3.9 CC1CN(C(CN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)C)CC3=CC=C(C=C3)F
CHEMBL197345 ccr1_mouse Mouse No 4.6 IC50 = 23000 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
444 5 1 4 3.9 CC1CN(C(CN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)C)CC3=CC=C(C=C3)F
CHEMBL68692 ccr1_human Human No 5.6 IC50 = 2320 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
521 11 2 6 4.2 CC(C)(CCC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)N4CCCC4)F
CHEMBL68692 ccr1_human Human No 5.6 IC50 = 2320 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
521 11 2 6 4.2 CC(C)(CCC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)N4CCCC4)F
CHEMBL2398731 ccr1_human Human No 6.6 IC50 = 233 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
522 6 3 6 3.3 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=C(C=C3)S(=O)(=O)N
CHEMBL232044 ccr1_human Human No 5.6 IC50 = 2340 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
501 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=CC=C4F
CHEMBL232044 ccr1_human Human No 5.6 IC50 = 2340 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
501 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=CC=C4F
CHEMBL387608 q9jly8_rat Rat No 7.6 IC50 = 24 Funct
Binding affinity at rat CCR1Binding affinity at rat CCR1
599 11 3 10 2.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCNCC4)CC5=CC=C(C=C5)F
CHEMBL387608 q9jly8_rat Rat No 7.6 IC50 = 24 Funct
Binding affinity at rat CCR1Binding affinity at rat CCR1
599 11 3 10 2.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCNCC4)CC5=CC=C(C=C5)F
CHEMBL2180506 ccr1_human Human No 7.6 IC50 = 24 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
417 5 1 3 5.1 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC(=CC=C3)F
CHEMBL257452 ccr1_human Human No 6.6 IC50 = 240 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
491 8 2 6 4.4 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3C4=CC=CS4
CHEMBL257452 ccr1_human Human No 6.6 IC50 = 240 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
491 8 2 6 4.4 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3C4=CC=CS4
CHEMBL33639 ccr1_human Human No 6.6 IC50 = 240 Funct
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
499 4 1 3 7.0 C1CCCC(=CCC1)CN2CCC(CC2)NC(=O)C3C4=C(C=CC(=C4)Cl)OC5=C3C=C(C=C5)Cl
CHEMBL126978 ccr1_human Human No 6.6 IC50 = 240 Funct
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
564 13 4 4 5.4 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(CNC(=O)NCCCCO)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL411476 ccr1_human Human No 5.6 IC50 = 2460 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC(=C(C=C3)Cl)Cl
CHEMBL411476 ccr1_human Human No 5.6 IC50 = 2460 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC(=C(C=C3)Cl)Cl
CHEMBL67803 ccr1_human Human No 5.6 IC50 = 2490 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
448 10 3 4 4.2 CC(C)CC(CC(C(CC1=CC=CC=C1)NC(=O)C2=CC3=C(C=C2)N=CC=C3)O)C(=O)NC
CHEMBL232253 ccr1_human Human No 7.6 IC50 = 25 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
545 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Br)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL3334824 ccr1_human Human No 7.6 IC50 = 25 Funct
Antagonist activity at CCR1 receptor in human whole blood assessed as blocked of MIP-1alpha-mediated CD11b upregulation preincubated for 1 hrAntagonist activity at CCR1 receptor in human whole blood assessed as blocked of MIP-1alpha-mediated CD11b upregulation preincubated for 1 hr
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL232253 ccr1_human Human No 7.6 IC50 = 25 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
545 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Br)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL232253 ccr1_human Human No 7.6 IC50 = 25 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
545 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Br)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL3334824 ccr1_human Human No 7.6 IC50 = 25 Funct
Antagonist activity at CCR1 receptor in human whole blood assessed as blocked of MIP-1alpha-mediated CD11b upregulation preincubated for 1 hrAntagonist activity at CCR1 receptor in human whole blood assessed as blocked of MIP-1alpha-mediated CD11b upregulation preincubated for 1 hr
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL2180510 ccr1_human Human No 7.6 IC50 = 25 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
413 5 1 2 5.3 CC1=CC=C(C=C1)C(=O)NC(C(C)C)C(=O)N2CCC(CC2)C3=CC=C(C=C3)Cl
CHEMBL232253 ccr1_human Human No 7.6 IC50 = 25 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
545 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Br)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL258065 ccr1_human Human No 6.6 IC50 = 250 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
477 7 2 8 3.9 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3C(F)(F)F
CHEMBL258065 ccr1_human Human No 6.6 IC50 = 250 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
477 7 2 8 3.9 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3C(F)(F)F
CHEMBL2391800 q9jly8_rat Rat No 5.6 IC50 = 2500 Funct
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
505 6 2 7 3.1 C1CN(CC1O)C(=O)C2=C(C=C(C=C2)F)OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL34166 ccr1_human Human Yes 5.6 IC50 = 2500 Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
445 7 1 3 5.6 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL33580 ccr1_mouse Mouse No 5.6 IC50 = 2500 Funct
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
588 4 1 3 7.1 C1CCCC(=CCC1)CN2CCC(CC2)NC(=O)C3C4=C(C=CC(=C4)Br)OC5=C3C=C(C=C5)Br
CHEMBL2398752 ccr1_human Human No 4.6 IC50 = 25000 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
491 6 1 3 5.9 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)OC)NC(=O)C3=CC=C(C=C3)Cl
CHEMBL256449 ccr1_human Human No 5.6 IC50 = 2550 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
489 4 1 8 3.7 C1CN(CCC1N2CCC(CC2)(C3=CC(=C(C(=C3)F)F)F)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL256449 ccr1_human Human No 5.6 IC50 = 2550 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
489 4 1 8 3.7 C1CN(CCC1N2CCC(CC2)(C3=CC(=C(C(=C3)F)F)F)O)S(=O)(=O)C4=CC=CC=C4Cl
CHEMBL309338 ccr1_human Human No 5.6 IC50 = 2570 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
449 10 3 5 3.2 CC(C)CC(CC(C(CC1=CC=CC=C1)NC(=O)C2=CN=NC3=CC=CC=C32)O)C(=O)NC
CHEMBL2180540 ccr1_human Human No 6.6 IC50 = 259 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
413 5 1 2 5.4 CC(C)(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3
CHEMBL231829 ccr1_human Human No 7.6 IC50 = 26 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
501 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL232654 ccr1_human Human No 7.6 IC50 = 26 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
578 10 2 9 3.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCC4=CC=NC=C4)CC5=CC=C(C=C5)F
CHEMBL2180502 ccr1_human Human No 7.6 IC50 = 26 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
393 7 1 2 4.9 CC(C)CCC(=O)NC(C(C)C)C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl
CHEMBL231829 ccr1_human Human No 7.6 IC50 = 26 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
501 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)F
CHEMBL232654 ccr1_human Human No 7.6 IC50 = 26 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
578 10 2 9 3.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCC4=CC=NC=C4)CC5=CC=C(C=C5)F
CHEMBL69274 ccr1_human Human No 7.6 IC50 = 26 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
447 9 3 5 3.7 C1CCC(C1)C(CC(C(CC2=CC=CC=C2)NC(=O)C3=NC4=CC=CC=C4N=C3)O)C(=O)N
CHEMBL232441 ccr1_mouse Mouse No 6.6 IC50 = 260 Funct
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
487 7 2 8 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)N)CC4=CC=C(C=C4)F
CHEMBL232441 ccr1_mouse Mouse No 6.6 IC50 = 260 Funct
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
487 7 2 8 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)N)CC4=CC=C(C=C4)F
CHEMBL282285 ccr1_human Human Yes 6.6 IC50 = 260 Funct
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
432 6 1 5 5.3 C1CN(CCC1NC(=O)CSC2=NC3=CC=CC=C3S2)CC4=CC=C(C=C4)Cl
CHEMBL3138187 ccr1_human Human No 6.6 IC50 = 260 Funct
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
768 12 4 6 16.5 CC(C)CCCC(C)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)CCC=C(C5=CC(=C(C(=C5)Cl)O)C(=O)O)C6=CC(=C(C(=C6)Cl)O)C(=O)O)C)C
CHEMBL307535 ccr1_human Human No 5.6 IC50 = 2600 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
467 10 3 6 3.7 CC(C)CC(CC(C(CC1=CC=C(C=C1)F)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)NC
CHEMBL1910159 ccr1_human Human No 6.6 IC50 = 261 Funct
Displacement of [125I]-MIP-1alpha 125I]-MCP1 from CCR1 expressed in CHO-K1 cells by scintillation proximity assayDisplacement of [125I]-MIP-1alpha 125I]-MCP1 from CCR1 expressed in CHO-K1 cells by scintillation proximity assay
428 7 2 7 2.3 CC1=C(C(=NO1)C)S(=O)(=O)NCCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O
CHEMBL1910159 ccr1_human Human No 6.6 IC50 = 261 Funct
Displacement of [125I]-MIP-1alpha 125I]-MCP1 from CCR1 expressed in CHO-K1 cells by scintillation proximity assayDisplacement of [125I]-MIP-1alpha 125I]-MCP1 from CCR1 expressed in CHO-K1 cells by scintillation proximity assay
428 7 2 7 2.3 CC1=C(C(=NO1)C)S(=O)(=O)NCCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O
CHEMBL2180544 ccr1_human Human No 6.6 IC50 = 262 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
427 5 1 2 5.7 CC1=CC=CC=C1C(=O)NC(C(=O)N2CCC(CC2)C3=CC=C(C=C3)Cl)C(C)(C)C
CHEMBL2180517 ccr1_human Human No 6.6 IC50 = 265 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
415 6 1 3 5.3 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)OC3=CC=CC=C3
CHEMBL305423 ccr1_human Human No 7.6 IC50 = 27 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
483 11 4 7 3.0 CC(C)(CCC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)NO)F
CHEMBL402827 ccr1_human Human No 6.6 IC50 = 270 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
483 4 1 5 4.4 CC1=C(C(=CC=C1)Cl)S(=O)(=O)N2CCCC(C2)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL455162 ccr1_human Human No 6.6 IC50 = 270 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
406 4 1 2 3.9 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)Cl
CHEMBL454942 ccr1_human Human No 6.6 IC50 = 270 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
420 5 1 2 4.3 CCN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)Cl
CHEMBL232042 ccr1_human Human No 6.6 IC50 = 270 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
562 8 2 7 4.1 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)Br
CHEMBL402827 ccr1_human Human No 6.6 IC50 = 270 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
483 4 1 5 4.4 CC1=C(C(=CC=C1)Cl)S(=O)(=O)N2CCCC(C2)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL455162 ccr1_human Human No 6.6 IC50 = 270 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
406 4 1 2 3.9 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)Cl
CHEMBL454942 ccr1_human Human No 6.6 IC50 = 270 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
420 5 1 2 4.3 CCN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)Cl
CHEMBL232042 ccr1_human Human No 6.6 IC50 = 270 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
562 8 2 7 4.1 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=C(C=C4)Br
CHEMBL2322872 ccr1_human Human No 5.6 IC50 = 2700 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
417 4 0 7 3.4 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=CC=C3)OC)C(F)(F)F)Cl
CHEMBL198966 ccr1_human Human No 7.6 IC50 = 28 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
444 4 1 5 3.8 CC1CN(CCN1C(=O)C2=CC3=CC(=CC(=C3O2)NC(=O)C)Cl)CC4=CC=C(C=C4)F
CHEMBL304358 ccr1_human Human No 7.6 IC50 = 28 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
449 11 3 5 3.7 CC(C)CCC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)N
CHEMBL198966 ccr1_human Human No 7.6 IC50 = 28 Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
444 4 1 5 3.8 CC1CN(CCN1C(=O)C2=CC3=CC(=CC(=C3O2)NC(=O)C)Cl)CC4=CC=C(C=C4)F
CHEMBL2180528 ccr1_human Human No 7.6 IC50 = 28 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
399 5 1 2 5.0 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3
CHEMBL304358 ccr1_human Human No 7.6 IC50 = 28 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
449 11 3 5 3.7 CC(C)CCC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)N
CHEMBL256271 ccr1_human Human No 6.6 IC50 = 280 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
483 4 1 5 4.5 CC1CC(CCN1S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL270863 ccr1_human Human No 6.6 IC50 = 280 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=C(C=CC(=C3)Cl)Cl
CHEMBL256271 ccr1_human Human No 6.6 IC50 = 280 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
483 4 1 5 4.5 CC1CC(CCN1S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL270863 ccr1_human Human No 6.6 IC50 = 280 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=C(C=CC(=C3)Cl)Cl
CHEMBL68551 ccr1_human Human No 6.6 IC50 = 280 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
469 10 3 5 3.4 C1=CC=C(C=C1)CC(CC(C(CC2=CC=CC=C2)NC(=O)C3=NC4=CC=CC=C4N=C3)O)C(=O)N
CHEMBL2180546 ccr1_human Human No 5.6 IC50 = 2832 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
417 5 3 4 2.3 CC(C(C(=O)N1CCC(CC1)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=CC=C3)O
CHEMBL2398757 ccr1_human Human No 7.5 IC50 = 29 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
428 5 1 3 4.7 CC(C)C(C(=O)N1CCC(C(C1)(C)C)C2=CC=C(C=C2)Cl)NC(=O)C3=CN=CC=C3
CHEMBL517290 ccr1_human Human No 6.5 IC50 = 290 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
402 5 1 3 3.3 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)OC
CHEMBL517290 ccr1_human Human No 6.5 IC50 = 290 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
402 5 1 3 3.3 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)OC
CHEMBL67757 ccr1_human Human No 5.5 IC50 = 2900 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
479 11 3 6 3.5 CC(C)CC(CC(C(CC1=CC=C(C=C1)OC)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)NC
CHEMBL232251 ccr1_human Human No 5.5 IC50 = 2910 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
501 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC(=CC=C4)F
CHEMBL232251 ccr1_human Human No 5.5 IC50 = 2910 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
501 8 2 8 3.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC(=CC=C4)F
CHEMBL2398732 ccr1_human Human No 5.5 IC50 = 2940 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
487 6 3 5 4.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=CC=C3C(=O)O
CHEMBL333422 ccr1_human Human Yes 6.5 IC50 = 295 Funct
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
614 12 3 4 7.4 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(CNC(=O)NCCC3=CC=C(C=C3)F)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL462442 ccr1_human Human No 5.5 IC50 = 2950 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
440 4 1 5 4.2 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=CC(=C3)C(F)(F)F
CHEMBL462442 ccr1_human Human No 5.5 IC50 = 2950 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
440 4 1 5 4.2 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=CC(=C3)C(F)(F)F
CHEMBL3334725 ccr1_human Human No 8.5 IC50 = 3 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
450 5 3 3 4.1 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCCC3
CHEMBL2398716 ccr1_human Human Yes 8.5 IC50 = 3 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
439 6 3 4 2.9 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CC(C)(C)O
CHEMBL3334815 ccr1_human Human No 8.5 IC50 = 3 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL3334816 ccr1_human Human No 8.5 IC50 = 3 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
438 6 3 3 4.2 CCC(C)NC(=O)NC(C(C)C)C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O
CHEMBL3334727 ccr1_human Human No 8.5 IC50 = 3 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL3334725 ccr1_human Human No 8.5 IC50 = 3 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
450 5 3 3 4.1 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCCC3
CHEMBL2398745 ccr1_human Human No 8.5 IC50 = 3 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
407 5 2 3 3.5 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CC3
CHEMBL2398767 ccr1_human Human No 8.5 IC50 = 3 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
522 6 3 6 3.3 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC(=CC=C3)S(=O)(=O)N
CHEMBL2398716 ccr1_human Human Yes 8.5 IC50 = 3 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
439 6 3 4 2.9 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CC(C)(C)O
CHEMBL3334815 ccr1_human Human No 8.5 IC50 = 3 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL3334816 ccr1_human Human No 8.5 IC50 = 3 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
438 6 3 3 4.2 CCC(C)NC(=O)NC(C(C)C)C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O
CHEMBL3334727 ccr1_human Human No 8.5 IC50 = 3 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL2398722 ccr1_human Human No 8.5 IC50 = 3.1 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
451 5 3 4 3.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCCC3O
CHEMBL3334824 ccr1_human Human No 8.5 IC50 = 3.2 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of HCC4-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of HCC4-induced chemotaxis after 60 mins
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL2391794 ccr1_human Human No 8.5 IC50 = 3.2 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
430 6 3 7 2.4 CNC(=O)C1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)F)O
CHEMBL3334824 ccr1_human Human No 8.5 IC50 = 3.2 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of HCC4-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of HCC4-induced chemotaxis after 60 mins
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL3099961 ccr1_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
445 6 4 7 2.1 CNC(=O)NC1=C(C=C(C=C1)O)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)F)O
CHEMBL3099948 ccr1_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
448 6 4 6 2.3 C1CN(CCC12CC3=C(O2)C=CC(=C3)Cl)CC(COC4=C(C=CC(=C4)O)NC(=O)N)O
CHEMBL3334824 ccr1_human Human No 8.5 IC50 = 3.3 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of RANTES-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of RANTES-induced chemotaxis after 60 mins
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL3334824 ccr1_human Human No 8.5 IC50 = 3.3 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of RANTES-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of RANTES-induced chemotaxis after 60 mins
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL2398730 ccr1_human Human No 8.5 IC50 = 3.3 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
477 5 2 3 5.3 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=C(C=C3)Cl
CHEMBL2178569 ccr1_human Human No 8.5 IC50 = 3.4 Funct
Antagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assayAntagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assay
519 5 2 6 2.6 CC1(CN(CC(C1O)C2=CC=C(C=C2)Cl)CCC=C3C4=C(COC5=C3C=C(C=C5)C(=O)O)N=CC=C4)C
CHEMBL2398765 ccr1_human Human No 8.5 IC50 = 3.4 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
577 7 4 4 4.9 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=CC(=C3)C4=CC=CC=C4NC(=O)N
CHEMBL2398769 ccr1_human Human No 8.5 IC50 = 3.5 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
458 6 2 4 3.6 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CC3=CC=NC=C3
CHEMBL2398741 ccr1_human Human No 8.4 IC50 = 3.6 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
395 5 2 3 3.5 CCC(=O)NC(C(C)C)C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O
CHEMBL2398757 ccr1_human Human No 8.4 IC50 = 3.7 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
428 5 1 3 4.7 CC(C)C(C(=O)N1CCC(C(C1)(C)C)C2=CC=C(C=C2)Cl)NC(=O)C3=CN=CC=C3
CHEMBL2322875 ccr1_human Human No 8.4 IC50 = 3.9 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced chemotaxisAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced chemotaxis
451 4 0 7 4.0 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C(F)(F)F)Cl
CHEMBL255629 ccr1_human Human No 7.5 IC50 = 30 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=C(C=CC=C3Cl)Cl
CHEMBL256404 ccr1_human Human No 7.5 IC50 = 30 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
423 7 2 5 3.4 CC1=CC=CC=C1S(=O)(=O)NCCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O
CHEMBL200242 ccr1_human Human No 7.5 IC50 = 30 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
485 7 1 5 3.7 CN(C)CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F
CHEMBL198949 ccr1_human Human Yes 7.5 IC50 = 30 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
430 5 1 4 3.5 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL199412 ccr1_human Human No 7.5 IC50 = 30 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
447 5 1 5 3.1 CC1CN(CCN1C(=O)C=CC2=C(C=C3C(=C2)C=CC=N3)NC(=O)C)CC4=CC=C(C=C4)F
CHEMBL391302 ccr1_human Human No 7.5 IC50 = 30 Funct
Binding Affinity at CCL3Binding Affinity at CCL3
477 8 2 6 2.7 CC1CN(C(CN1C(=O)COC2=C(C=C(C=C2)Cl)C(=O)NCCN)C)CC3=CC=C(C=C3)F
CHEMBL255629 ccr1_human Human No 7.5 IC50 = 30 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=C(C=CC=C3Cl)Cl
CHEMBL256404 ccr1_human Human No 7.5 IC50 = 30 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
423 7 2 5 3.4 CC1=CC=CC=C1S(=O)(=O)NCCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O
CHEMBL200242 ccr1_human Human No 7.5 IC50 = 30 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
485 7 1 5 3.7 CN(C)CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F
CHEMBL198949 ccr1_human Human Yes 7.5 IC50 = 30 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
430 5 1 4 3.5 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL199412 ccr1_human Human No 7.5 IC50 = 30 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
447 5 1 5 3.1 CC1CN(CCN1C(=O)C=CC2=C(C=C3C(=C2)C=CC=N3)NC(=O)C)CC4=CC=C(C=C4)F
CHEMBL391302 ccr1_human Human No 7.5 IC50 = 30 Funct
Binding Affinity at CCL3Binding Affinity at CCL3
477 8 2 6 2.7 CC1CN(C(CN1C(=O)COC2=C(C=C(C=C2)Cl)C(=O)NCCN)C)CC3=CC=C(C=C3)F
CHEMBL2180528 ccr1_human Human No 7.5 IC50 = 30 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
399 5 1 2 5.0 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3
CHEMBL2180496 ccr1_human Human No 7.5 IC50 = 30 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
413 6 1 2 4.9 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)CC3=CC=CC=C3
CHEMBL371248 ccr1_human Human No 6.5 IC50 = 300 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
442 5 1 4 3.6 CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2CC3CCC(C2)N3CC4=CC=C(C=C4)F
CHEMBL196860 ccr1_mouse Mouse No 6.5 IC50 = 300 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
431 5 2 4 2.9 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL199412 ccr1_human Human No 6.5 IC50 = 300 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
447 5 1 5 3.1 CC1CN(CCN1C(=O)C=CC2=C(C=C3C(=C2)C=CC=N3)NC(=O)C)CC4=CC=C(C=C4)F
CHEMBL270631 ccr1_human Human No 6.5 IC50 = 300 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
409 7 2 5 3.1 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3
CHEMBL371248 ccr1_human Human No 6.5 IC50 = 300 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
442 5 1 4 3.6 CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2CC3CCC(C2)N3CC4=CC=C(C=C4)F
CHEMBL196860 ccr1_mouse Mouse No 6.5 IC50 = 300 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
431 5 2 4 2.9 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL199412 ccr1_human Human No 6.5 IC50 = 300 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
447 5 1 5 3.1 CC1CN(CCN1C(=O)C=CC2=C(C=C3C(=C2)C=CC=N3)NC(=O)C)CC4=CC=C(C=C4)F
CHEMBL270631 ccr1_human Human No 6.5 IC50 = 300 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
409 7 2 5 3.1 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3
CHEMBL200794 ccr1_mouse Mouse No 5.5 IC50 = 3000 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
443 4 2 4 3.5 CC1CN(CCN1C(=O)C2=CC3=CC(=CC(=C3N2)NC(=O)C)Cl)CC4=CC=C(C=C4)F
CHEMBL370162 ccr1_mouse Mouse No 5.5 IC50 = 3000 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
433 6 2 5 3.1 CC1CN(CCN1C(=O)CNC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL200794 ccr1_mouse Mouse No 5.5 IC50 = 3000 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
443 4 2 4 3.5 CC1CN(CCN1C(=O)C2=CC3=CC(=CC(=C3N2)NC(=O)C)Cl)CC4=CC=C(C=C4)F
CHEMBL370162 ccr1_mouse Mouse No 5.5 IC50 = 3000 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
433 6 2 5 3.1 CC1CN(CCN1C(=O)CNC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL2322875 ccr1_mouse Mouse No 5.5 IC50 = 3000 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in mouse WEHI274.1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in mouse WEHI274.1 cells
451 4 0 7 4.0 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C(F)(F)F)Cl
CHEMBL142318 ccr1_human Human No 5.5 IC50 = 3000 Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
473 5 1 5 5.2 C1CN(CCC1(C2=CC=C(C=C2)F)O)CCCC3(C4=CC=CC=C4CSC5=CC=CC=C53)C#N
CHEMBL308243 ccr1_human Human No 4.5 IC50 = 30000 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
454 10 3 4 5.3 CC(C)CC(CC(C(CC1CCCCC1)NC(=O)C2=CC3=CC=CC=C3N=C2)O)C(=O)NC
CHEMBL2180519 ccr1_human Human No 6.5 IC50 = 303 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
449 7 1 4 4.6 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NS(=O)(=O)CC3=CC=CC=C3
CHEMBL2322888 ccr1_human Human Yes 6.5 IC50 = 307 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
405 3 0 7 3.5 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC=C(C=C3)F)C(F)(F)F)Cl
CHEMBL232656 ccr1_human Human Yes 7.5 IC50 = 31 Funct
Binding Affinity at CCL3Binding Affinity at CCL3
435 6 2 5 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL232656 ccr1_human Human Yes 7.5 IC50 = 31 Funct
Binding Affinity at CCL3Binding Affinity at CCL3
435 6 2 5 2.5 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL305423 ccr1_human Human No 7.5 IC50 = 31 Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
483 11 4 7 3.0 CC(C)(CCC(CC(C(CC1=CC=CC=C1)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)NO)F
CHEMBL124127 ccr1_human Human No 7.5 IC50 = 31 Funct
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
550 12 4 4 5.0 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(CNC(=O)NCCCO)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL2322888 ccr1_human Human Yes 6.5 IC50 = 310 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
405 3 0 7 3.5 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC=C(C=C3)F)C(F)(F)F)Cl
CHEMBL333063 ccr1_human Human No 6.5 IC50 = 310 Funct
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
665 12 3 4 7.4 C1CN(CCC1NC(=O)NCC(CCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O)(C4=CC=CC=C4)C5=CC=CC=C5)CC6=CC=CC=C6
CHEMBL1224120 ccr1_human Human No 7.5 IC50 = 32 Funct
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
450 4 1 6 4.4 C1CC(N(C1)C(=O)NC2=CC=C(C=C2)C(F)(F)F)C3=NC=NN3CC4=CC=C(C=C4)Cl
CHEMBL2391811 ccr1_human Human No 7.5 IC50 = 32 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
503 6 2 7 2.7 C1CN(CCC12CC3=C(O2)C=CC(=C3)Cl)CC(COC4=C(C=CC(=C4)O)C(=O)N5CCOCC5)O
CHEMBL1224120 ccr1_human Human No 7.5 IC50 = 32 Funct
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
450 4 1 6 4.4 C1CC(N(C1)C(=O)NC2=CC=C(C=C2)C(F)(F)F)C3=NC=NN3CC4=CC=C(C=C4)Cl
CHEMBL2180509 ccr1_human Human No 7.5 IC50 = 32 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
413 5 1 2 5.3 CC1=CC=CC=C1C(=O)NC(C(C)C)C(=O)N2CCC(CC2)C3=CC=C(C=C3)Cl
CHEMBL2180525 ccr1_human Human No 7.5 IC50 = 32 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
379 6 1 2 4.6 CC(C)CC(=O)NC(C(C)C)C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl
CHEMBL3099952 ccr1_human Human No 7.5 IC50 = 32 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
443 5 2 5 3.2 C1CC(=O)NC2=C1C=CC=C2OCC(CN3CCC4(CC3)CC5=C(O4)C=CC(=C5)Cl)O
CHEMBL2332939 ccr1_human Human No 7.5 IC50 = 32 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
426 7 2 6 2.3 CC(=O)NC1=C(C=C(C=C1)OC)OCC(CN2CCC3(CC2)CC4=CC=CC=C4O3)N
CHEMBL198949 ccr1_human Human Yes 6.5 IC50 = 320 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
430 5 1 4 3.5 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL256271 ccr1_human Human No 6.5 IC50 = 320 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
483 4 1 5 4.5 CC1CC(CCN1S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL198949 ccr1_human Human Yes 6.5 IC50 = 320 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
430 5 1 4 3.5 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL256271 ccr1_human Human No 6.5 IC50 = 320 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
483 4 1 5 4.5 CC1CC(CCN1S(=O)(=O)C2=CC=CC=C2Cl)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL143194 ccr1_human Human No 5.5 IC50 = 3200 Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
408 7 1 4 3.7 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(CC#N)(C#N)C3=CC=CC=C3
CHEMBL2322893 ccr1_human Human No 4.5 IC50 = 32000 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
417 4 0 7 3.4 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC=C(C=C3)OC)C(F)(F)F)Cl
CHEMBL2180550 ccr1_human Human No 6.5 IC50 = 324 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
429 6 2 3 4.2 CC(C)CC(C(=O)N1CCC(CC1)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=CC=C3
CHEMBL256887 ccr1_human Human No 6.5 IC50 = 330 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
550 4 1 7 4.3 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=C(C=C(C=C4Br)F)F
CHEMBL256887 ccr1_human Human No 6.5 IC50 = 330 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
550 4 1 7 4.3 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=C(C=C(C=C4Br)F)F
CHEMBL2323422 ccr1_human Human No 5.5 IC50 = 3300 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
401 3 0 6 3.8 CC1=CC(=CC=C1)N2CCN(CC2)C(=O)CN3C(=C(C(=N3)C(F)(F)F)Cl)C
CHEMBL142925 ccr1_human Human No 5.5 IC50 = 3300 Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
500 5 1 4 4.7 CN1C2=CC=CC=C2C(C3=CC=CC=C3C1=O)(CCCN4CCC(CC4)(C5=CC=C(C=C5)Cl)O)C#N
CHEMBL2180526 ccr1_human Human No 7.5 IC50 = 34 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
393 7 1 2 4.9 CCC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)CC(C)C
CHEMBL2322848 ccr1_human Human No 6.5 IC50 = 340 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
398 4 1 5 2.7 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)N)Cl
CHEMBL2322866 ccr1_human Human No 5.5 IC50 = 3400 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
513 5 0 7 5.3 COC1=C(C=CC(=C1)N2CCN(CC2)C(=O)CN3C(=C(C(=N3)C(F)(F)F)Cl)C4=CC=CC=C4)Cl
CHEMBL2398719 ccr1_human Human No 6.5 IC50 = 341 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
450 5 3 4 3.0 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)N
CHEMBL69876 ccr1_human Human No 5.5 IC50 = 3460 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
463 9 3 6 2.1 C1COCCC1C(CC(C(CC2=CC=CC=C2)NC(=O)C3=NC4=CC=CC=C4N=C3)O)C(=O)N
CHEMBL473531 ccr1_human Human No 7.5 IC50 = 35 Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
474 4 1 5 4.8 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=C(C=C(C=C3)C(F)(F)F)Cl
CHEMBL473531 ccr1_human Human No 7.5 IC50 = 35 Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
474 4 1 5 4.8 CN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=C(C=C(C=C3)C(F)(F)F)Cl
CHEMBL2180515 ccr1_human Human No 7.5 IC50 = 35 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
427 7 1 2 5.2 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)CCC3=CC=CC=C3
CHEMBL258360 ccr1_human Human No 6.5 IC50 = 350 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=C(C(=CC=C3)Cl)Cl
CHEMBL231830 ccr1_human Human No 6.5 IC50 = 350 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
483 8 2 7 3.4 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=CC=C4
CHEMBL258361 ccr1_human Human No 6.5 IC50 = 350 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
493 8 2 9 4.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3OC(F)(F)F
CHEMBL255338 ccr1_human Human No 6.5 IC50 = 350 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
491 8 2 6 4.4 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3C4=CSC=C4
CHEMBL258360 ccr1_human Human No 6.5 IC50 = 350 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=C(C(=CC=C3)Cl)Cl
CHEMBL231830 ccr1_human Human No 6.5 IC50 = 350 Funct
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
483 8 2 7 3.4 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NC)CC4=CC=CC=C4
CHEMBL258361 ccr1_human Human No 6.5 IC50 = 350 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
493 8 2 9 4.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3OC(F)(F)F
CHEMBL255338 ccr1_human Human No 6.5 IC50 = 350 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
491 8 2 6 4.4 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3C4=CSC=C4
CHEMBL68368 ccr1_human Human No 5.5 IC50 = 3500 Funct
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
463 9 3 6 2.1 C1COCCC1C(CC(C(CC2=CC=CC=C2)NC(=O)C3=NC4=CC=CC=C4N=C3)O)C(=O)N
CHEMBL402327 ccr1_human Human No 5.5 IC50 = 3570 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
497 4 1 5 4.6 CC1=C(C(=CC=C1)Cl)S(=O)(=O)N2CCC(CC2)(C)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL402327 ccr1_human Human No 5.5 IC50 = 3570 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
497 4 1 5 4.6 CC1=C(C(=CC=C1)Cl)S(=O)(=O)N2CCC(CC2)(C)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL2180542 ccr1_human Human No 7.4 IC50 = 36 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
413 5 1 2 5.3 CC1=CC=CC=C1C(=O)NC(C(C)C)C(=O)N2CCC(CC2)C3=CC=C(C=C3)Cl
CHEMBL411477 ccr1_human Human No 6.4 IC50 = 360 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=C(C=C(C=C3)Cl)Cl
CHEMBL381446 ccr1_human Human No 6.4 IC50 = 360 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
432 6 1 4 3.3 CC1CN(CCN1C(=O)CCC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL257509 ccr1_human Human No 6.4 IC50 = 360 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
461 7 2 6 3.8 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=C(C=C(C=C3)F)Cl
CHEMBL411477 ccr1_human Human No 6.4 IC50 = 360 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=C(C=C(C=C3)Cl)Cl
CHEMBL381446 ccr1_human Human No 6.4 IC50 = 360 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
432 6 1 4 3.3 CC1CN(CCN1C(=O)CCC2=C(C=C(C=C2)Cl)NC(=O)C)CC3=CC=C(C=C3)F
CHEMBL257509 ccr1_human Human No 6.4 IC50 = 360 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
461 7 2 6 3.8 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=C(C=C(C=C3)F)Cl
CHEMBL339752 ccr1_human Human No 6.4 IC50 = 360 Funct
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
603 12 3 4 6.2 C1CCN(CC1)CCNC(=O)NCC(CCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O)(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL509457 ccr1_human Human No 5.4 IC50 = 3600 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
434 6 1 2 4.8 CCCN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)Cl
CHEMBL258369 ccr1_human Human No 5.4 IC50 = 3600 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
538 4 1 5 5.3 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=C(C(=C(C=C4)Cl)Cl)Cl
CHEMBL21143 ccr1_human Human No 5.4 IC50 = 3600 Funct
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
510 8 1 6 6.2 CCOC1=CC2=C(C=C1)N=C(S2)SCC(=O)NC3CCN(CC3)CC4=CC(=C(C=C4)Cl)Cl
CHEMBL509457 ccr1_human Human No 5.4 IC50 = 3600 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
434 6 1 2 4.8 CCCN(CC1=CC=C(C=C1)Cl)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)Cl
CHEMBL258369 ccr1_human Human No 5.4 IC50 = 3600 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
538 4 1 5 5.3 C1CN(CCC1N2CCC(CC2)(C3=CC=C(C=C3)Cl)O)S(=O)(=O)C4=C(C(=C(C=C4)Cl)Cl)Cl
CHEMBL258362 ccr1_human Human No 5.4 IC50 = 3650 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
493 8 2 9 4.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=C(C=C3)OC(F)(F)F
CHEMBL258362 ccr1_human Human No 5.4 IC50 = 3650 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
493 8 2 9 4.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=C(C=C3)OC(F)(F)F
CHEMBL2322892 ccr1_human Human No 5.4 IC50 = 3650 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
401 3 0 6 3.8 CC1=CC=C(C=C1)N2CCN(CC2)C(=O)CN3C(=C(C(=N3)C(F)(F)F)Cl)C
CHEMBL2322852 ccr1_human Human No 7.4 IC50 = 37 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
465 4 0 7 4.4 CC1CN(CCN1C(=O)CN2C(=C(C(=N2)C(F)(F)F)Cl)C)C3=CC(=C(C=C3)Cl)OC
CHEMBL3099953 ccr1_human Human No 7.4 IC50 = 37 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
441 5 2 5 3.4 C1CN(CCC12CC3=C(O2)C=CC(=C3)Cl)CC(COC4=CC=CC5=C4NC(=O)C=C5)O
CHEMBL404732 ccr1_human Human No 6.4 IC50 = 370 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
443 7 2 5 3.7 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=C(C=C3)Cl
CHEMBL269956 ccr1_human Human No 6.4 IC50 = 370 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
483 4 1 5 4.4 CC1=C(C(=CC=C1)Cl)S(=O)(=O)N2CCC(CC2)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL404732 ccr1_human Human No 6.4 IC50 = 370 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
443 7 2 5 3.7 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=C(C=C3)Cl
CHEMBL2180547 ccr1_human Human No 6.4 IC50 = 370 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
399 4 2 3 3.4 CC=C(C(=O)N1CCC(CC1)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=CC=C3
CHEMBL269956 ccr1_human Human No 6.4 IC50 = 370 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
483 4 1 5 4.4 CC1=C(C(=CC=C1)Cl)S(=O)(=O)N2CCC(CC2)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL2180536 ccr1_human Human No 6.4 IC50 = 375 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
434 5 1 3 4.9 CC(C)C(C(=O)N1CCN(CC1)C2=CC(=C(C=C2)Cl)Cl)NC(=O)C3=CC=CC=C3
CHEMBL397910 ccr1_human Human No 7.4 IC50 = 38 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
578 10 2 9 3.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCC4=CN=CC=C4)CC5=CC=C(C=C5)F
CHEMBL234262 ccr1_human Human No 7.4 IC50 = 38 Funct
Binding Affinity at CCL3Binding Affinity at CCL3
449 7 1 6 1.5 CC1CN(C(CN1C(=O)COC2=C(C=C(C=C2)Cl)CC(=O)O)C)CC3=CC=C(C=C3)F
CHEMBL397910 ccr1_human Human No 7.4 IC50 = 38 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
578 10 2 9 3.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCC4=CN=CC=C4)CC5=CC=C(C=C5)F
CHEMBL234262 ccr1_human Human No 7.4 IC50 = 38 Funct
Binding Affinity at CCL3Binding Affinity at CCL3
449 7 1 6 1.5 CC1CN(C(CN1C(=O)COC2=C(C=C(C=C2)Cl)CC(=O)O)C)CC3=CC=C(C=C3)F
CHEMBL2180497 ccr1_human Human No 7.4 IC50 = 38 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
427 7 1 2 5.3 CCC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)CC3=CC=CC=C3
CHEMBL256821 ccr1_human Human No 6.4 IC50 = 380 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
443 7 2 5 3.7 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC(=CC=C3)Cl
CHEMBL256821 ccr1_human Human No 6.4 IC50 = 380 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
443 7 2 5 3.7 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC(=CC=C3)Cl
CHEMBL270564 ccr1_human Human No 6.4 IC50 = 385 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
415 7 2 6 2.7 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CSC=C3
CHEMBL270564 ccr1_human Human No 6.4 IC50 = 385 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
415 7 2 6 2.7 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CSC=C3
CHEMBL1910160 ccr1_human Human No 6.4 IC50 = 387 Funct
Displacement of [125I]-MIP-1alpha 125I]-MCP1 from CCR1 expressed in CHO-K1 cells by scintillation proximity assayDisplacement of [125I]-MIP-1alpha 125I]-MCP1 from CCR1 expressed in CHO-K1 cells by scintillation proximity assay
464 9 2 4 4.3 C1CN(CC1OC2=CC=C(C=C2)F)CCCCNC(=O)NCC3=CC=C(C=C3)Br
CHEMBL1910160 ccr1_human Human No 6.4 IC50 = 387 Funct
Displacement of [125I]-MIP-1alpha 125I]-MCP1 from CCR1 expressed in CHO-K1 cells by scintillation proximity assayDisplacement of [125I]-MIP-1alpha 125I]-MCP1 from CCR1 expressed in CHO-K1 cells by scintillation proximity assay
464 9 2 4 4.3 C1CN(CC1OC2=CC=C(C=C2)F)CCCCNC(=O)NCC3=CC=C(C=C3)Br
CHEMBL2180537 ccr1_human Human No 6.4 IC50 = 388 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
365 5 1 2 4.3 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C(C)C
CHEMBL272559 ccr1_human Human No 5.4 IC50 = 3880 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
439 8 2 6 3.0 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O
CHEMBL272559 ccr1_human Human No 5.4 IC50 = 3880 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
439 8 2 6 3.0 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O
CHEMBL387608 ccr1_human Human No 7.4 IC50 = 39 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
599 11 3 10 2.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCNCC4)CC5=CC=C(C=C5)F
CHEMBL387608 ccr1_human Human No 7.4 IC50 = 39 Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
599 11 3 10 2.9 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)NCCN4CCNCC4)CC5=CC=C(C=C5)F
CHEMBL402827 ccr1_human Human No 6.4 IC50 = 390 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
483 4 1 5 4.4 CC1=C(C(=CC=C1)Cl)S(=O)(=O)N2CCCC(C2)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL402827 ccr1_human Human No 6.4 IC50 = 390 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
483 4 1 5 4.4 CC1=C(C(=CC=C1)Cl)S(=O)(=O)N2CCCC(C2)N3CCC(CC3)(C4=CC=C(C=C4)Cl)O
CHEMBL1224188 ccr1_human Human No 8.4 IC50 = 4 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
450 4 1 6 3.8 C1CC(N(C1)C(=O)NC2=CC=C(C=C2)C(F)(F)F)C3=NN=CN3CC4=CC=C(C=C4)Cl
CHEMBL3334728 ccr1_human Human No 8.4 IC50 = 4 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL232441 ccr1_human Human No 8.4 IC50 = 4 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
487 7 2 8 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)N)CC4=CC=C(C=C4)F
CHEMBL200629 ccr1_human Human No 8.4 IC50 = 4 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
460 6 1 5 3.4 CC1CN(CCN1C(=O)C=CC2=CC(=C(C=C2NC(=O)C)Cl)OC)CC3=CC=C(C=C3)F
CHEMBL372807 ccr1_mouse Mouse No 8.4 IC50 = 4 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
472 6 1 5 3.6 CC(=O)NC1=CC(=C(C=C1C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F)OC)Cl
CHEMBL3334726 ccr1_human Human No 8.4 IC50 = 4 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL1224188 ccr1_human Human No 8.4 IC50 = 4 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
450 4 1 6 3.8 C1CC(N(C1)C(=O)NC2=CC=C(C=C2)C(F)(F)F)C3=NN=CN3CC4=CC=C(C=C4)Cl
CHEMBL3334728 ccr1_human Human No 8.4 IC50 = 4 Funct
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL2398726 ccr1_human Human No 8.4 IC50 = 4 Funct
Antagonist activity at human CCR1 assessed as inhibition of HCC-1-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of HCC-1-induced chemotaxis
451 5 3 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)O
CHEMBL232441 ccr1_human Human No 8.4 IC50 = 4 Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
487 7 2 8 2.8 CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC3=C(C(=O)C3=O)N)CC4=CC=C(C=C4)F
CHEMBL200629 ccr1_human Human No 8.4 IC50 = 4 Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
460 6 1 5 3.4 CC1CN(CCN1C(=O)C=CC2=CC(=C(C=C2NC(=O)C)Cl)OC)CC3=CC=C(C=C3)F
CHEMBL372807 ccr1_mouse Mouse No 8.4 IC50 = 4 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
472 6 1 5 3.6 CC(=O)NC1=CC(=C(C=C1C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F)OC)Cl
CHEMBL2322875 ccr1_human Human No 8.4 IC50 = 4 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
451 4 0 7 4.0 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C(F)(F)F)Cl
CHEMBL3334726 ccr1_human Human No 8.4 IC50 = 4 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
466 5 4 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NC3CCC(C3)O
CHEMBL2398737 ccr1_human Human No 8.4 IC50 = 4.1 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
457 6 2 3 4.6 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)CC3=CC=CC=C3
CHEMBL2398758 ccr1_human Human No 8.4 IC50 = 4.1 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
420 5 1 3 4.8 CC(C)C(C(=O)N1CCN(C(C1)(C)C)C2=CC=C(C=C2)Cl)NC(=O)C3CCCC3
CHEMBL3334824 ccr1_human Human No 8.4 IC50 = 4.2 Funct
Displacement of [125I]hMIP-1alpha from CCR1 in human PBMCDisplacement of [125I]hMIP-1alpha from CCR1 in human PBMC
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL3334824 ccr1_human Human No 8.4 IC50 = 4.2 Funct
Displacement of [125I]hMIP-1alpha from CCR1 in human PBMCDisplacement of [125I]hMIP-1alpha from CCR1 in human PBMC
454 6 4 4 2.8 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)NCC(C)(C)O
CHEMBL2398735 ccr1_human Human No 8.4 IC50 = 4.3 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
444 5 2 4 3.6 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CN=CC=C3
CHEMBL2398742 ccr1_human Human No 8.4 IC50 = 4.4 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
409 5 2 3 4.1 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C(C)C
CHEMBL2398726 ccr1_human Human No 8.4 IC50 = 4.4 Funct
Antagonist activity at human CCR1 assessed as inhibition of ieukotactin-1-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of ieukotactin-1-induced chemotaxis
451 5 3 4 3.2 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3CCC(C3)O
CHEMBL2398741 ccr1_human Human No 8.4 IC50 = 4.5 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
395 5 2 3 3.5 CCC(=O)NC(C(C)C)C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O
CHEMBL3099941 ccr1_human Human No 8.4 IC50 = 4.5 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
476 7 3 6 3.0 CNC(=O)NC1=C(C=C(C=C1)OC)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)Cl)O
CHEMBL2398742 ccr1_human Human No 8.3 IC50 = 4.6 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
409 5 2 3 4.1 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C(C)C
CHEMBL2398770 ccr1_human Human No 8.3 IC50 = 4.7 Funct
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
477 5 2 3 5.3 CC(C)C(C(=O)N1CCC(C(C1)(C)C)(C2=CC=C(C=C2)Cl)O)NC(=O)C3=CC=CC=C3Cl
CHEMBL2322875 ccr1_human Human No 8.3 IC50 = 4.8 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assay
451 4 0 7 4.0 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C(F)(F)F)Cl
CHEMBL269957 ccr1_human Human No 7.4 IC50 = 40 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
443 7 2 5 3.7 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3Cl
CHEMBL429419 ccr1_human Human No 7.4 IC50 = 40 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
457 7 2 5 4.1 CC1=C(C(=CC=C1)Cl)S(=O)(=O)NCCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O
CHEMBL200242 ccr1_mouse Mouse No 7.4 IC50 = 40 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
485 7 1 5 3.7 CN(C)CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F
CHEMBL196860 ccr1_human Human No 7.4 IC50 = 40 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
431 5 2 4 2.9 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL269957 ccr1_human Human No 7.4 IC50 = 40 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
443 7 2 5 3.7 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=CC=CC=C3Cl
CHEMBL429419 ccr1_human Human No 7.4 IC50 = 40 Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
457 7 2 5 4.1 CC1=C(C(=CC=C1)Cl)S(=O)(=O)NCCCN2CCC(CC2)(C3=CC=C(C=C3)Cl)O
CHEMBL200242 ccr1_mouse Mouse No 7.4 IC50 = 40 Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
485 7 1 5 3.7 CN(C)CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F
CHEMBL196860 ccr1_human Human No 7.4 IC50 = 40 Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
431 5 2 4 2.9 CC1CN(CCN1C(=O)C=CC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F
CHEMBL2398766 ccr1_human Human No 7.4 IC50 = 40 Funct
Binding affinity to human CCR1Binding affinity to human CCR1
478 6 2 5 3.5 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)C3=CC(=CC=C3)S(=O)(=O)N
CHEMBL2322843 ccr1_human Human No 7.4 IC50 = 40 Funct
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
397 4 0 4 3.5 CC1=C(C(=NN1CC(=O)N2CCN(CC2)C3=CC(=C(C=C3)Cl)OC)C)Cl
CHEMBL2180499 ccr1_human Human No 7.4 IC50 = 40 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
427 7 1 2 5.2 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)CCC3=CC=CC=C3
CHEMBL2180514 ccr1_human Human No 7.4 IC50 = 40 Funct
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
413 6 1 2 4.9 CC(C)C(C(=O)N1CCC(CC1)C2=CC=C(C=C2)Cl)NC(=O)CC3=CC=CC=C3
CHEMBL404465 ccr1_human Human No 6.4 IC50 = 400 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
483 4 1 5 4.4 C1CC(CCN(C1)C2CCN(CC2)S(=O)(=O)C3=CC=CC=C3Cl)(C4=CC=C(C=C4)Cl)O
CHEMBL2391936 ccr1_human Human No 6.4 IC50 = 400 Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
476 8 4 7 2.0 C1CN(CCC12CC3=C(O2)C=CC(=C3)Cl)CC(COC4=C(C=CC(=C4)O)C(=O)NCCN)O
CHEMBL404465 ccr1_human Human No 6.4 IC50 = 400 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
483 4 1 5 4.4 C1CC(CCN(C1)C2CCN(CC2)S(=O)(=O)C3=CC=CC=C3Cl)(C4=CC=C(C=C4)Cl)O
CHEMBL357919 ccr1_human Human Yes 6.4 IC50 = 400 Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
431 6 1 3 5.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL460535 ccr1_human Human No 5.4 IC50 = 4000 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
420 4 1 2 4.3 CC1=C(C=CC(=C1)CN(C)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)Cl)Cl
CHEMBL460535 ccr1_human Human No 5.4 IC50 = 4000 Funct
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
420 4 1 2 4.3 CC1=C(C=CC(=C1)CN(C)C(=O)C2CCCN2C(=O)NC3=CC=C(C=C3)Cl)Cl
CHEMBL200242 ccr1_human Human No 7.4 IC50 = 41 Funct
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
485 7 1 5 3.7 CN(C)CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F
CHEMBL200242 ccr1_human Human No 7.4 IC50 = 41 Funct
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
485 7 1 5 3.7 CN(C)CC(=O)NC1=C(C=CC(=C1)Cl)C=CC(=O)N2C3CCC2CN(C3)CC4=CC=C(C=C4)F
CHEMBL411477 ccr1_human Human No 6.4 IC50 = 410 Funct
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
478 7 2 5 4.3 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCNS(=O)(=O)C3=C(C=C(C=C3)Cl)Cl