Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL2372983 ccr5_human Human No 9.8 EC50 = 0.2 Funct
Effective concentration for antagonistic activity by inhibition of T-tropic strain of HIV-1 through its specific binding to a chemokine receptorEffective concentration for antagonistic activity by inhibition of T-tropic strain of HIV-1 through its specific binding to a chemokine receptor
2023 46 30 28 -8.6 C1CC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2C1)CCCCN)CCCCN)CCCN=C(N)N)CC3=CC=C(C=C3)O)NC(=O)C(C4=CC5=CC=CC=C5C=C4)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N)C(=O)NC(CCCN=C(N)N)C(=O)O)CCCNC(=O)N)CCCN=C(N)N)CC6=CC=C(C=C6)O
CHEMBL425618 ccr5_human Human Yes 9.0 EC50 = 1 Funct
Antagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assayAntagonist activity at CCR5 in human TZM-bl cells infected with CCR5-tropic HIV-1 Bal assessed as inhibition of viral entry after 3 days by luciferase reporter gene assay
514 8 1 6 5.1 CC1=NN=C(N1C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
CHEMBL99384 ccr5_human Human Yes 6.0 EC50 = 1000 Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
236 0 0 2 3.9 CC1=CN=C2C(=C1C)C=CC3=C(C(=CN=C32)C)C
CHEMBL2205801 ccr5_human Human Yes 5.0 EC50 = 10000 Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
236 2 0 4 1.4 C1=CC2=C(C=CN=C2C3=NC=CC(=C31)C=O)C=O
CHEMBL220199 ccr5_human Human Yes 6.0 EC50 = 1100 Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
476 7 1 6 3.7 CC1=CC=C(C=C1)CN2CCC(C2)CNC(=O)C3CCN(CC3)C4=NN=C(C=C4)C5=CC=CS5
CHEMBL220199 ccr5_human Human Yes 6.0 EC50 = 1100 Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
476 7 1 6 3.7 CC1=CC=C(C=C1)CN2CCC(C2)CNC(=O)C3CCN(CC3)C4=NN=C(C=C4)C5=CC=CS5
CHEMBL101165 ccr5_human Human Yes 5.0 EC50 = 11000 Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.2 CC1=CC(=NC=C1)C2=NC=CC(=C2)C
CHEMBL219769 ccr5_human Human Yes 4.9 EC50 = 13500 Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
436 7 1 5 4.1 CC1=CC=C(C=C1)N2C(=NN=C2SCC(=O)NC3CCN(CC3)CC4=CC=CC=C4)C
CHEMBL219769 ccr5_human Human Yes 4.9 EC50 = 13500 Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
436 7 1 5 4.1 CC1=CC=C(C=C1)N2C(=NN=C2SCC(=O)NC3CCN(CC3)CC4=CC=CC=C4)C
CHEMBL316589 ccr5_human Human Yes 5.8 EC50 = 1800 Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 2.1 CC1=C2C=CC3=C(C2=NC=C1)N=CC=C3
CHEMBL223686 ccr5_human Human Yes 5.7 EC50 = 1900 Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
390 9 1 4 6.4 CCN(CC)CCCNC1=C(C(=C(C2=NC3=CC=CC=C3N12)C#N)C)CC(=C)C
CHEMBL223686 ccr5_human Human Yes 5.7 EC50 = 1900 Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
390 9 1 4 6.4 CCN(CC)CCCNC1=C(C(=C(C2=NC3=CC=CC=C3N12)C#N)C)CC(=C)C
CHEMBL2205809 ccr5_human Human Yes 5.7 EC50 = 1900 Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.2 CC1=CN=C2C(=C1)C=CC3=CC(=CN=C32)C
CHEMBL39879 ccr5_human Human Yes 4.7 EC50 = 19000 Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
156 1 0 2 1.7 C1=CC=NC(=C1)C2=CC=CC=N2
CHEMBL219770 ccr5_human Human Yes 5.7 EC50 = 2000 Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
451 7 1 6 3.2 CC1=C(C=CC(=C1)CN2CCN(CC2)C)NC(=O)CSC3=NN=C(N3C4=CC=CC=C4)C
CHEMBL219770 ccr5_human Human Yes 5.7 EC50 = 2000 Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
451 7 1 6 3.2 CC1=C(C=CC(=C1)CN2CCN(CC2)C)NC(=O)CSC3=NN=C(N3C4=CC=CC=C4)C
CHEMBL2205810 ccr5_human Human Yes 5.7 EC50 = 2200 Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 2.1 CC1=CN=C2C(=C1)C=CC3=C2N=CC=C3
CHEMBL2205808 ccr5_human Human Yes 4.7 EC50 = 22000 Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
216 3 0 4 1.4 COC1=CC(=NC=C1)C2=NC=CC(=C2)OC
CHEMBL2205807 ccr5_human Human Yes 5.6 EC50 = 2300 Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.2 CC1=CN=C(C=C1)C2=NC=C(C=C2)C
CHEMBL593442 ccr5_human Human Yes 5.6 EC50 = 2600 Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.2 CC1=C2C=CC3=C(C=CN=C3C2=NC=C1)C
CHEMBL89445 ccr5_human Human Yes 4.5 EC50 = 29000 Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
233 2 0 3 2.4 C1=CC=NC(=C1)C2=NC(=CC=C2)C3=CC=CC=N3
CHEMBL219781 ccr5_human Human Yes 5.5 EC50 = 3000 Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
464 9 1 5 4.7 CC1=CC(=C(C=C1)NC(=O)CSC2=NN=C(N2CC3=CC=CC=C3)CCN4CCCCC4)C
CHEMBL219781 ccr5_human Human Yes 5.5 EC50 = 3000 Funct
Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayAgonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assay
464 9 1 5 4.7 CC1=CC(=C(C=C1)NC(=O)CSC2=NN=C(N2CC3=CC=CC=C3)CCN4CCCCC4)C
CHEMBL415879 ccr5_human Human Yes 5.3 EC50 = 4900 Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
180 0 0 2 1.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1
CHEMBL375781 ccr5_human Human Yes 4.2 EC50 = 67000 Funct
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.3 CC1=NC2=C(C=C1)C=CC3=C2N=C(C=C3)C
CHEMBL311795 ccr5_human Human Yes 11.0 IC50 = 0.0 Funct
Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5
504 4 0 8 4.3 CC1CN(CCN1C(C)C2=CC=C(C=C2)C(F)(F)F)C3(CCN(CC3)C(=O)C4=C(N=CN=C4C)C)C
CHEMBL460845 ccr5_human Human Yes 10.3 IC50 = 0.1 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
545 10 1 3 6.2 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)CC4=CC(=C(C=C4)Cl)Cl
CHEMBL460845 ccr5_human Human Yes 10.3 IC50 = 0.1 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
545 10 1 3 6.2 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)CC4=CC(=C(C=C4)Cl)Cl
CHEMBL21106 ccr5_human Human No 10.2 IC50 = 0.1 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
547 11 1 8 4.7 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL21106 ccr5_human Human No 10.2 IC50 = 0.1 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
547 11 1 8 4.7 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL21106 ccr5_human Human No 10.2 IC50 = 0.1 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
547 11 1 8 4.7 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL21106 ccr5_human Human No 10.2 IC50 = 0.1 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
547 11 1 8 4.7 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL457043 ccr5_human Human Yes 10.2 IC50 = 0.1 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
554 11 1 5 4.1 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL457043 ccr5_human Human Yes 10.2 IC50 = 0.1 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
554 11 1 5 4.1 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL2164207 ccr5_human Human Yes 10.1 IC50 = 0.1 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
528 9 2 6 4.3 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)NOC)Cl)Cl
CHEMBL1926899 ccr5_human Human No 10.1 IC50 = 0.1 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
601 12 2 7 5.3 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(N=C(C=C3C)C(=O)NC(C)C)C)C4=CC=C(C=C4)OC
CHEMBL1926899 ccr5_human Human No 10.1 IC50 = 0.1 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
601 12 2 7 5.3 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(N=C(C=C3C)C(=O)NC(C)C)C)C4=CC=C(C=C4)OC
CHEMBL1649924 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
498 7 1 6 2.6 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC(=CC=C5)F)NC(=O)C)CN(CC2)C(=O)OC
CHEMBL20896 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
489 11 1 4 5.2 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL316475 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
475 11 1 4 4.7 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL320386 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
475 10 1 4 4.5 C1CC(C1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL20345 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
543 11 1 7 5.0 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCSC5=CC=C(C=C5)F
CHEMBL20345 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
543 11 1 7 5.0 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCSC5=CC=C(C=C5)F
CHEMBL20896 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
489 11 1 4 5.2 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL1649924 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
498 7 1 6 2.6 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC(=CC=C5)F)NC(=O)C)CN(CC2)C(=O)OC
CHEMBL2164202 ccr5_human Human Yes 10.0 IC50 = 0.1 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
562 10 1 7 3.6 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)CN4CCOC4=O)C)Cl
CHEMBL2164210 ccr5_human Human Yes 10.0 IC50 = 0.1 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
519 9 2 7 3.4 CC1=C(C(=NC(=C1)C#N)Cl)C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)NOC
CHEMBL20896 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
489 11 1 4 5.2 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL316475 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
475 11 1 4 4.7 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL320386 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
475 10 1 4 4.5 C1CC(C1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL20345 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
543 11 1 7 5.0 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCSC5=CC=C(C=C5)F
CHEMBL316475 ccr5_human Human No 10.0 IC50 = 0.1 Funct
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
475 11 1 4 4.7 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL320386 ccr5_human Human No 10.0 IC50 = 0.1 Funct
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
475 10 1 4 4.5 C1CC(C1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL102826 ccr5_human Human No 10.0 IC50 = 0.1 Funct
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
503 10 1 4 5.6 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL20896 ccr5_human Human No 10.0 IC50 = 0.1 Funct
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
489 11 1 4 5.2 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL328445 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
569 11 0 6 6.0 C=CCN(C1CCN(CC1)CC2CN(CC2C3=CC=CC=C3)CC4=CC=CC=C4)C(=O)OCC5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL93139 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
635 14 0 8 6.2 CC(CCN1CCC(CC1)N(CC=C)C(=O)OCC2=CC=C(C=C2)[N+](=O)[O-])(CN(C)S(=O)(=O)C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL2164217 ccr5_human Human No 10.0 IC50 = 0.1 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
555 9 2 6 4.2 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)NC4=CN=CC=C4)C)Cl
CHEMBL157491 ccr5_human Human No 9.9 IC50 = 0.1 Funct
Ability to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesAbility to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
589 9 0 7 6.4 C=CCN(C1CCN(CC1)CC2CN3C(C2C4=CC=CC=C4)CC5(O3)CCCCC5)C(=O)OCC6=CC=C(C=C6)[N+](=O)[O-]
CHEMBL473558 ccr5_human Human Yes 9.9 IC50 = 0.1 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
452 8 1 4 4.7 CC1=NN=C(N1C2CCN(CC2)C(C)CC(C3=CC=CC=C3)NC(=O)C4CCCC4)C(C)C
CHEMBL473558 ccr5_human Human Yes 9.9 IC50 = 0.1 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
452 8 1 4 4.7 CC1=NN=C(N1C2CCN(CC2)C(C)CC(C3=CC=CC=C3)NC(=O)C4CCCC4)C(C)C
CHEMBL461687 ccr5_human Human Yes 9.8 IC50 = 0.2 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
491 10 2 3 4.6 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)NCC4=CC=CC=C4
CHEMBL461687 ccr5_human Human Yes 9.8 IC50 = 0.2 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
491 10 2 3 4.6 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)NCC4=CC=CC=C4
CHEMBL2178577 ccr5_human Human No 9.8 IC50 = 0.2 Funct
Binding affinity to CCR5Binding affinity to CCR5
639 11 0 8 4.7 CCN(C1CCN(CC1)CCC(C2CCC(CC2)S(=O)(=O)C)C3=CC(=CC(=C3)F)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL3085308 ccr5_human Human Yes 9.7 IC50 = 0.2 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
698 17 1 8 6.9 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=NN=CN5CCC)CC(C)C
CHEMBL3085308 ccr5_human Human Yes 9.7 IC50 = 0.2 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
698 17 1 8 6.9 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=NN=CN5CCC)CC(C)C
CHEMBL1926893 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
550 10 1 6 5.8 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(N=C(C=C3C)Cl)C)C4=CC=C(C=C4)OC
CHEMBL1649926 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
498 7 1 6 2.6 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC(=CC=C5)F)NC(=O)OC)CN(CC2)C(=O)C
CHEMBL1649927 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
514 8 1 7 3.0 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC(=CC=C5)F)NC(=O)OC)CN(CC2)C(=O)OC
CHEMBL20622 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
543 11 1 7 5.1 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL21147 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
575 11 1 8 6.2 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCCC5=CC=C(C=C5)C(F)(F)F
CHEMBL319593 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
543 10 2 6 6.0 C1CCC(CC1)CN2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=C(C=C5)C6=NNN=N6)O
CHEMBL99909 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
489 10 1 4 5.0 C1CCC(C1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL20622 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
543 11 1 7 5.1 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL21147 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
575 11 1 8 6.2 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCCC5=CC=C(C=C5)C(F)(F)F
CHEMBL1926893 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
550 10 1 6 5.8 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(N=C(C=C3C)Cl)C)C4=CC=C(C=C4)OC
CHEMBL1649926 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
498 7 1 6 2.6 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC(=CC=C5)F)NC(=O)OC)CN(CC2)C(=O)C
CHEMBL1649927 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
514 8 1 7 3.0 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC(=CC=C5)F)NC(=O)OC)CN(CC2)C(=O)OC
CHEMBL319593 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
543 10 2 6 6.0 C1CCC(CC1)CN2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=C(C=C5)C6=NNN=N6)O
CHEMBL322422 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
557 10 1 6 6.1 CN1C(=NN=N1)C2=CC=C(C=C2)CCCC3(CCN(CC3)CC4CN(CC4C5=CC=CC=C5)CC6CCCCC6)O
CHEMBL20622 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
543 11 1 7 5.1 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL21147 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
575 11 1 8 6.2 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCCC5=CC=C(C=C5)C(F)(F)F
CHEMBL319593 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
543 10 2 6 6.0 C1CCC(CC1)CN2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=C(C=C5)C6=NNN=N6)O
CHEMBL99909 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
489 10 1 4 5.0 C1CCC(C1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL319593 ccr5_human Human No 9.7 IC50 = 0.2 Funct
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
543 10 2 6 6.0 C1CCC(CC1)CN2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=C(C=C5)C6=NNN=N6)O
CHEMBL99909 ccr5_human Human No 9.7 IC50 = 0.2 Funct
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
489 10 1 4 5.0 C1CCC(C1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL102826 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Inhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assayInhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assay
503 10 1 4 5.6 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL173400 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
611 11 1 6 5.3 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC6=CC=CC=C6C=C5
CHEMBL174927 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
611 10 1 6 5.3 CCN1C(=CC(=N1)CC2=CC=CC3=CC=CC=C32)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(=O)O)C(C)(C)C
CHEMBL171958 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
643 12 1 7 5.3 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC3CC3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C7CCCCC7)C(=O)O
CHEMBL366770 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
611 11 1 6 5.3 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=CC6=CC=CC=C65
CHEMBL369235 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
611 10 1 6 5.3 CCN1C(=CC(=N1)CC2=CC3=CC=CC=C3C=C2)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(=O)O)C(C)(C)C
CHEMBL329893 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
575 10 0 6 5.5 C=CCN(C1CCN(CC1)CC2CN(CC2C3=CC=CC=C3)C(=O)C4CCCC4)C(=O)OCC5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL431852 ccr5_human Human No 9.7 IC50 = 0.2 Funct
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
583 10 0 6 5.6 C=CCN(C1CCN(CC1)CC2CN(CC2C3=CC=CC=C3)C(=O)C4=CC=CC=C4)C(=O)OCC5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL3085309 ccr5_human Human Yes 9.7 IC50 = 0.2 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
735 17 1 8 6.0 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CC6=CN(N=C6)C
CHEMBL3085309 ccr5_human Human Yes 9.7 IC50 = 0.2 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
735 17 1 8 6.0 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CC6=CN(N=C6)C
CHEMBL212731 ccr5_human Human Yes 9.7 IC50 = 0.2 Funct
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
615 11 0 7 4.6 CCN(C1CCN(CC1)CCC(C2=CC=C(C=C2)S(=O)(=O)C)C3=CC(=CC=C3)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL212731 ccr5_human Human Yes 9.7 IC50 = 0.2 Funct
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
615 11 0 7 4.6 CCN(C1CCN(CC1)CCC(C2=CC=C(C=C2)S(=O)(=O)C)C3=CC(=CC=C3)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL511493 ccr5_human Human No 9.6 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
544 10 1 6 4.7 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(S5)CC6=CC=CC=C6
CHEMBL520091 ccr5_human Human No 9.6 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
530 10 1 6 4.2 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(S5)CC6=CC=CC=C6
CHEMBL511493 ccr5_human Human No 9.6 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
544 10 1 6 4.7 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(S5)CC6=CC=CC=C6
CHEMBL520091 ccr5_human Human No 9.6 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
530 10 1 6 4.2 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(S5)CC6=CC=CC=C6
CHEMBL326487 ccr5_human Human No 9.6 IC50 = 0.2 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
530 10 1 6 4.2 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(S5)CC6=CC=CC=C6
CHEMBL333619 ccr5_human Human No 9.6 IC50 = 0.2 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
544 10 1 6 4.7 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(S5)CC6=CC=CC=C6
CHEMBL511493 ccr5_human Human No 9.6 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
544 10 1 6 4.7 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(S5)CC6=CC=CC=C6
CHEMBL520091 ccr5_human Human No 9.6 IC50 = 0.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
530 10 1 6 4.2 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(S5)CC6=CC=CC=C6
CHEMBL3085307 ccr5_human Human Yes 9.6 IC50 = 0.2 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
683 17 1 7 7.0 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CCC
CHEMBL3085307 ccr5_human Human Yes 9.6 IC50 = 0.2 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
683 17 1 7 7.0 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CCC
CHEMBL2110727 ccr5_mouse Mouse Yes 9.6 IC50 = 0.3 Funct
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
697 17 1 7 7.5 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CC(C)C
CHEMBL1951914 ccr5_human Human Yes 9.6 IC50 = 0.3 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
640 11 0 9 3.9 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC(=CC(=C3)F)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL1951914 ccr5_human Human Yes 9.6 IC50 = 0.3 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
640 11 0 9 3.9 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC(=CC(=C3)F)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL480503 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
558 9 1 6 5.1 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(S5)CC6=CC=CC=C6
CHEMBL480503 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
558 9 1 6 5.1 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(S5)CC6=CC=CC=C6
CHEMBL480503 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
558 9 1 6 5.1 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(S5)CC6=CC=CC=C6
CHEMBL480503 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
558 9 1 6 5.1 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(S5)CC6=CC=CC=C6
CHEMBL455073 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
571 11 1 7 6.2 C1CCC(CC1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL21117 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
561 11 1 8 5.2 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL1927009 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
561 10 1 7 5.5 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CC=CC(=N3)C#N)C4=CC=C(C=C4)OC)C)Cl
CHEMBL1927008 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
552 10 1 8 4.6 CC1=C(C(=NC(=C1)C#N)C)C(=O)NCCC(C)N2CCC(CC2)N(CC3=CC=CC(=N3)C#N)C4=CC=C(C=C4)OC
CHEMBL1926898 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
541 10 1 7 4.9 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(C=C(N=C3C)C#N)C)C4=CC=C(C=C4)OC
CHEMBL1926896 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
534 10 1 7 5.3 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(N=C(C=C3C)F)C)C4=CC=C(C=C4)OC
CHEMBL1649922 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
480 7 1 5 2.5 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC=CC=C5)NC(=O)C)CN(CC2)C(=O)OC
CHEMBL455073 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
571 11 1 7 6.2 C1CCC(CC1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL21117 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
561 11 1 8 5.2 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL21117 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
561 11 1 8 5.2 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL20988 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
532 11 1 6 5.0 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCCC5=CC=C(C=C5)C#N
CHEMBL282921 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
557 10 1 7 5.5 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL1927009 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
561 10 1 7 5.5 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CC=CC(=N3)C#N)C4=CC=C(C=C4)OC)C)Cl
CHEMBL1927008 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
552 10 1 8 4.6 CC1=C(C(=NC(=C1)C#N)C)C(=O)NCCC(C)N2CCC(CC2)N(CC3=CC=CC(=N3)C#N)C4=CC=C(C=C4)OC
CHEMBL1926898 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
541 10 1 7 4.9 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(C=C(N=C3C)C#N)C)C4=CC=C(C=C4)OC
CHEMBL1926896 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
534 10 1 7 5.3 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(N=C(C=C3C)F)C)C4=CC=C(C=C4)OC
CHEMBL1649922 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
480 7 1 5 2.5 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC=CC=C5)NC(=O)C)CN(CC2)C(=O)OC
CHEMBL2164205 ccr5_human Human Yes 9.5 IC50 = 0.3 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
494 8 3 6 3.2 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)NO)C)Cl
CHEMBL2164206 ccr5_human Human Yes 9.5 IC50 = 0.3 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
508 9 2 6 3.8 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)NOC)C)Cl
CHEMBL2164203 ccr5_human Human Yes 9.5 IC50 = 0.3 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
492 8 2 5 3.7 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)NC)C)Cl
CHEMBL2164211 ccr5_human Human Yes 9.5 IC50 = 0.3 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
552 12 2 7 3.6 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)NOCCOC)C)Cl
CHEMBL194497 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
523 8 1 7 3.8 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=CN=C6N5C=C(C=C6)F
CHEMBL317710 ccr5_human Human Yes 9.5 IC50 = 0.3 Funct
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes.Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes.
475 9 1 3 6.8 C1CCC(CC1)CN2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=CC=C5)O
CHEMBL455073 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
571 11 1 7 6.2 C1CCC(CC1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL21117 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
561 11 1 8 5.2 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)(F)F
CHEMBL2435848 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
592 5 0 4 6.0 CC1=CC(=NC(=C1C(=O)N2CCC(CC2)(C)N3CCC(CC3)N4C(CN(C4=O)C5CCCCC5)C6=CC=CC=C6)C)Cl
CHEMBL172916 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
617 13 1 7 4.6 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OC6CC6
CHEMBL172894 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
611 11 1 6 5.3 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC6=CC=CC=C6C=C5
CHEMBL174004 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
637 12 1 6 5.7 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)C6=CC=CC=C6
CHEMBL177127 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
627 13 1 9 5.0 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OC(F)F
CHEMBL279992 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
617 12 1 6 5.7 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)C(C)(C)C
CHEMBL366868 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
603 12 1 6 5.2 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)C(C)C
CHEMBL367987 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
623 11 1 6 5.3 CCN1C(=CC(=N1)CC2=CC=C(C=C2)C3=CC=CC=C3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(C)C)C(=O)O
CHEMBL368329 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
663 11 1 6 6.4 CCN1C(=CC(=N1)CC2=CC=C(C=C2)C3=CC=CC=C3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C7CCCCC7)C(=O)O
CHEMBL369059 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
617 13 1 7 4.6 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OC6CC6
CHEMBL427493 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
629 10 1 9 5.0 CCN1C(=CC(=N1)CC2=CC=C(C=C2)C(F)(F)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL435472 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
575 11 1 6 4.4 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)C
CHEMBL212689 ccr5_human Human Yes 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
633 11 0 8 4.7 CCN(C1CCN(CC1)CCC(C2=CC=C(C=C2)S(=O)(=O)C)C3=CC(=CC(=C3)F)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL212689 ccr5_human Human Yes 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
633 11 0 8 4.7 CCN(C1CCN(CC1)CCC(C2=CC=C(C=C2)S(=O)(=O)C)C3=CC(=CC(=C3)F)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL212689 ccr5_human Human Yes 9.5 IC50 = 0.3 Funct
Binding affinity to CCR5Binding affinity to CCR5
633 11 0 8 4.7 CCN(C1CCN(CC1)CCC(C2=CC=C(C=C2)S(=O)(=O)C)C3=CC(=CC(=C3)F)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL212689 ccr5_human Human Yes 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
633 11 0 8 4.7 CCN(C1CCN(CC1)CCC(C2=CC=C(C=C2)S(=O)(=O)C)C3=CC(=CC(=C3)F)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL212689 ccr5_human Human Yes 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
633 11 0 8 4.7 CCN(C1CCN(CC1)CCC(C2=CC=C(C=C2)S(=O)(=O)C)C3=CC(=CC(=C3)F)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL480693 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
528 10 1 6 4.1 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(O5)CC6=CC=CC=C6
CHEMBL459384 ccr5_human Human Yes 9.5 IC50 = 0.3 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
510 10 1 3 5.5 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)CC4=CC=C(C=C4)Cl
CHEMBL480693 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
528 10 1 6 4.1 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(O5)CC6=CC=CC=C6
CHEMBL459384 ccr5_human Human Yes 9.5 IC50 = 0.3 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
510 10 1 3 5.5 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)CC4=CC=C(C=C4)Cl
CHEMBL480693 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
528 10 1 6 4.1 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(O5)CC6=CC=CC=C6
CHEMBL480693 ccr5_human Human No 9.5 IC50 = 0.3 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
528 10 1 6 4.1 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(O5)CC6=CC=CC=C6
CHEMBL193984 ccr5_human Human No 9.5 IC50 = 0.4 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
533 9 1 6 4.5 CCC1=CC2=NC=C(N2C=C1)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(CC6CCC6)C(=O)O
CHEMBL193984 ccr5_human Human No 9.5 IC50 = 0.4 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
533 9 1 6 4.5 CCC1=CC2=NC=C(N2C=C1)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(CC6CCC6)C(=O)O
CHEMBL1784385 ccr5_human Human Yes 9.5 IC50 = 0.4 Funct
Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation countingDisplacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation counting
513 6 0 3 6.5 CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C(C)(C)C)C6=CC=CC=C6
CHEMBL1784385 ccr5_human Human Yes 9.5 IC50 = 0.4 Funct
Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation countingDisplacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation counting
513 6 0 3 6.5 CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C(C)(C)C)C6=CC=CC=C6
CHEMBL489513 ccr5_human Human Yes 9.4 IC50 = 0.4 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
474 8 1 6 4.2 CC1=NN=C(N1C2CCN(CC2)C(C)CC(C3=CC=CC=C3)NC(=O)C4CC(C4)(F)F)C(C)C
CHEMBL489513 ccr5_human Human Yes 9.4 IC50 = 0.4 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
474 8 1 6 4.2 CC1=NN=C(N1C2CCN(CC2)C(C)CC(C3=CC=CC=C3)NC(=O)C4CC(C4)(F)F)C(C)C
CHEMBL2112559 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
527 10 2 5 3.8 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(N5)CC6=CC=CC=C6
CHEMBL20453 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
527 11 2 7 3.4 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)O
CHEMBL464132 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
557 10 1 6 6.7 CN1N=C(N=N1)C2=CC=C(C=C2)CCCC3(CCN(CC3)CC4CN(CC4C5=CC=CC=C5)CC6CCCCC6)O
CHEMBL1288663 ccr5_human Human Yes 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
849 12 2 10 7.6 CC(C)(C)NS(=O)(=O)C1=C(C=C(C(=C1)C(=O)N2CCC(CC2)(CCN3CCC(CC3)N(C4=CC(=CC=C4)F)C(=O)NCC5=CC=C(C=C5)C#N)C6=CC(=CC=C6)F)Cl)F
CHEMBL257000 ccr5_human Human Yes 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 receptor by [35S]GTP-gamma-S binding assayAntagonist activity at CCR5 receptor by [35S]GTP-gamma-S binding assay
609 7 1 7 4.6 CC1=NC2=C(N1C3CC4CCC(C3)N4CCCN(C5=CC=CC=C5)C(=O)NC6=CC=C(C=C6)C(F)(F)F)CCN(C2)C(=O)C
CHEMBL1649920 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
478 7 1 4 2.6 CCC(=O)N1CCC2=C(C1)N(C(=N2)C)C3CC4CCC(C3)N4CCC(C5=CC=CC=C5)NC(=O)C
CHEMBL1649919 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
464 6 1 4 2.1 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC=CC=C5)NC(=O)C)CN(CC2)C(=O)C
CHEMBL1649921 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
492 7 1 4 3.2 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC=CC=C5)NC(=O)C)CN(CC2)C(=O)C(C)C
CHEMBL1255794 ccr5_mouse Mouse No 9.4 IC50 = 0.4 Funct
Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hrDisplacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr
578 10 3 7 3.1 CCCCN1C(=O)C(NC(=O)C12CCN(CC2)CC3=CC=C(C=C3)OC4=CC=C(C=C4)C(=O)O)C(C5CCCCC5)O
CHEMBL20453 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
527 11 2 7 3.4 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)O
CHEMBL464132 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
557 10 1 6 6.7 CN1N=C(N=N1)C2=CC=C(C=C2)CCCC3(CCN(CC3)CC4CN(CC4C5=CC=CC=C5)CC6CCCCC6)O
CHEMBL20453 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
527 11 2 7 3.4 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)O
CHEMBL278117 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
559 11 1 8 3.5 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCS(=O)C5=CC=C(C=C5)F
CHEMBL1288663 ccr5_human Human Yes 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in HOS cells assessed as inhibition of HIV-1 Ba-L infection
849 12 2 10 7.6 CC(C)(C)NS(=O)(=O)C1=C(C=C(C(=C1)C(=O)N2CCC(CC2)(CCN3CCC(CC3)N(C4=CC(=CC=C4)F)C(=O)NCC5=CC=C(C=C5)C#N)C6=CC(=CC=C6)F)Cl)F
CHEMBL257000 ccr5_human Human Yes 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 receptor by [35S]GTP-gamma-S binding assayAntagonist activity at CCR5 receptor by [35S]GTP-gamma-S binding assay
609 7 1 7 4.6 CC1=NC2=C(N1C3CC4CCC(C3)N4CCCN(C5=CC=CC=C5)C(=O)NC6=CC=C(C=C6)C(F)(F)F)CCN(C2)C(=O)C
CHEMBL1649920 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
478 7 1 4 2.6 CCC(=O)N1CCC2=C(C1)N(C(=N2)C)C3CC4CCC(C3)N4CCC(C5=CC=CC=C5)NC(=O)C
CHEMBL1649919 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
464 6 1 4 2.1 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC=CC=C5)NC(=O)C)CN(CC2)C(=O)C
CHEMBL1649921 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
492 7 1 4 3.2 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC=CC=C5)NC(=O)C)CN(CC2)C(=O)C(C)C
CHEMBL2164209 ccr5_human Human Yes 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
544 9 2 6 3.4 CC1=CC(=[N+](C(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)NOC)Cl)[O-])Cl
CHEMBL2164208 ccr5_human Human Yes 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
559 11 3 7 3.2 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)NOC)C)C(=O)NC(C)C
CHEMBL2164220 ccr5_human Human Yes 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
502 9 1 6 3.8 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)CC#N)C)Cl
CHEMBL2164219 ccr5_human Human Yes 9.4 IC50 = 0.4 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
507 10 1 6 3.8 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)COC)C)Cl
CHEMBL344261 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
542 11 1 9 3.5 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CCC4)C(=O)O)C5=NC=C(C=N5)F
CHEMBL103790 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
558 10 2 5 7.3 C[N+]1=NC(=NN1)C2=CC=C(C=C2)CCCC3(CCN(CC3)CC4CN(CC4C5=CC=CC=C5)CC6CCCCC6)O
CHEMBL20453 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
527 11 2 7 3.4 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCC(C5=CC=C(C=C5)F)O
CHEMBL464132 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
557 10 1 6 6.7 CN1N=C(N=N1)C2=CC=C(C=C2)CCCC3(CCN(CC3)CC4CN(CC4C5=CC=CC=C5)CC6CCCCC6)O
CHEMBL2435857 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
587 8 1 7 2.5 CC1=C(C=CC(=N1)SC2=CC=C(C=C2)C(=O)O)CN3CCC(CC3)N4C(CN(C4=O)C5CCOCC5)C6=CC=CC=C6
CHEMBL366873 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
617 12 1 7 4.6 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC3CC3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(=O)O)C(C)(C)C
CHEMBL176669 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
623 13 1 8 4.5 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC(=C(C=C5)OCC)F
CHEMBL366611 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
611 11 1 6 5.3 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=CC6=CC=CC=C65
CHEMBL433793 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
605 12 1 7 4.4 CCN1C(=CC(=N1)CC2=CC(=CC=C2)OCC)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL174214 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
617 11 1 6 5.8 CCN1C(=CC(=N1)CC2=CC=C(C=C2)C(C)(C)C)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL176459 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
631 13 1 7 4.9 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OC6CCC6
CHEMBL175348 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
609 12 1 8 4.1 CCN1C(=CC(=N1)CC2=CC(=C(C=C2)OCC)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL262402 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
653 12 1 7 5.6 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC3=CC=CC=C3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(=O)O)C(C)(C)C
CHEMBL369812 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
653 13 1 7 5.6 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OC6=CC=CC=C6
CHEMBL2113086 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
505 8 1 6 3.7 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=CN=C6N5C=CC=C6
CHEMBL2113086 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
505 8 1 6 3.7 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=CN=C6N5C=CC=C6
CHEMBL1951913 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
618 11 0 7 4.0 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC=CC(=C3)C)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL1951913 ccr5_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
618 11 0 7 4.0 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC=CC(=C3)C)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL456226 ccr5_human Human Yes 9.3 IC50 = 0.5 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
544 10 1 6 5.8 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)CC4=CC=C(C=C4)C(F)(F)F
CHEMBL491319 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
474 8 1 6 4.2 CC1=NN=C(N1C2CCN(CC2)C(C)CC(C3=CC=CC=C3)NC(=O)C4CC(C4)(F)F)C(C)C
CHEMBL3085311 ccr5_human Human Yes 9.3 IC50 = 0.5 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
711 17 1 7 7.8 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CC(C)C
CHEMBL456226 ccr5_human Human Yes 9.3 IC50 = 0.5 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
544 10 1 6 5.8 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)CC4=CC=C(C=C4)C(F)(F)F
CHEMBL491319 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
474 8 1 6 4.2 CC1=NN=C(N1C2CCN(CC2)C(C)CC(C3=CC=CC=C3)NC(=O)C4CC(C4)(F)F)C(C)C
CHEMBL3085311 ccr5_human Human Yes 9.3 IC50 = 0.5 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
711 17 1 7 7.8 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CC(C)C
CHEMBL1649913 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
417 6 1 3 4.2 CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC(C5=CC=CC=C5)NC(=O)C
CHEMBL472464 ccr5_human Human Yes 9.3 IC50 = 0.5 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
488 6 0 3 4.9 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(CC4=CC=CC=C4)C(=O)C5CC5
CHEMBL278085 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
507 11 1 5 5.3 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL471920 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
549 11 1 8 4.9 CC(C)CC(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)CCC(C4=CC=C(C=C4)F)(F)F
CHEMBL255429 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
483 5 0 4 5.7 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CN=CC=C5
CHEMBL20831 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
535 10 1 8 4.6 CC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)CCC(C4=CC=C(C=C4)F)(F)F
CHEMBL278085 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
507 11 1 5 5.3 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL1649913 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
417 6 1 3 4.2 CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC(C5=CC=CC=C5)NC(=O)C
CHEMBL2164212 ccr5_human Human Yes 9.3 IC50 = 0.5 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
612 11 3 7 2.5 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)NCC4=CC=C(C=C4)C(=O)O)C)Cl
CHEMBL472464 ccr5_human Human Yes 9.3 IC50 = 0.5 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
488 6 0 3 4.9 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(CC4=CC=CC=C4)C(=O)C5CC5
CHEMBL292625 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
484 4 1 3 5.8 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)NC4=CC=C(C=C4)Br
CHEMBL344641 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
592 11 1 11 4.3 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CCC4)C(=O)O)C5=NC=C(C=N5)C(F)(F)F
CHEMBL371177 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
574 8 1 6 4.9 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=CN=C6N5C=C(C=C6Cl)Cl
CHEMBL278085 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
507 11 1 5 5.3 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCCC5=CC=CC=C5
CHEMBL471920 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
549 11 1 8 4.9 CC(C)CC(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)CCC(C4=CC=C(C=C4)F)(F)F
CHEMBL255429 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
483 5 0 4 5.7 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CN=CC=C5
CHEMBL322603 ccr5_human Human No 9.3 IC50 = 0.5 Funct
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
519 10 2 5 4.2 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=CC=C5)O
CHEMBL2435886 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
566 8 1 4 5.9 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)C4CCCCC4)C5=CC=CC=C5)C)Cl
CHEMBL173479 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
679 12 1 7 6.3 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC3=CC=CC=C3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C7CCCCC7)C(=O)O
CHEMBL367897 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
590 12 2 7 4.0 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC(=CC=C5)NC
CHEMBL367416 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
637 12 1 6 5.7 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)C6=CC=CC=C6
CHEMBL369478 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
629 11 1 9 4.9 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)C(F)(F)F
CHEMBL173583 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
619 14 1 7 4.9 CCCCOC1=CC=C(C=C1)CC2=NN(C(=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O)CC
CHEMBL175341 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
605 11 1 8 3.9 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC6=C(C=C5)OCO6
CHEMBL174996 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
627 12 1 9 5.0 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC(F)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL176528 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
603 10 2 7 4.4 CCN1C(=CC(=N1)CC2=CC=C(C=C2)O)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O
CHEMBL173091 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
659 12 1 7 5.7 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC(C)(C)C)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O
CHEMBL175079 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
616 12 1 8 3.7 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC(=C(C=C5)OC)C#N
CHEMBL177071 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
579 10 1 7 4.2 CCN1C(=CC(=N1)CC2=CC=CC=C2F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL265723 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
659 13 1 10 5.1 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OCC(F)(F)F
CHEMBL366610 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
629 11 1 9 4.9 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)C(F)(F)F
CHEMBL368000 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
667 14 1 7 5.5 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OCC6=CC=CC=C6
CHEMBL369593 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
653 13 1 7 5.6 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OC6=CC=CC=C6
CHEMBL369398 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
613 12 1 9 4.6 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC(F)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL513564 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
518 9 1 6 4.0 CC(C)C(C(=O)O)N1CC(C(C1)C2=CC=CC=C2)CN3CCC(CC3)C4=CN=C(S4)CC5=CC=CC=C5
CHEMBL513564 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
518 9 1 6 4.0 CC(C)C(C(=O)O)N1CC(C(C1)C2=CC=CC=C2)CN3CCC(CC3)C4=CN=C(S4)CC5=CC=CC=C5
CHEMBL513564 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
518 9 1 6 4.0 CC(C)C(C(=O)O)N1CC(C(C1)C2=CC=CC=C2)CN3CCC(CC3)C4=CN=C(S4)CC5=CC=CC=C5
CHEMBL513564 ccr5_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
518 9 1 6 4.0 CC(C)C(C(=O)O)N1CC(C(C1)C2=CC=CC=C2)CN3CCC(CC3)C4=CN=C(S4)CC5=CC=CC=C5
CHEMBL473759 ccr5_human Human Yes 9.3 IC50 = 0.5 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
466 8 1 4 5.2 CC1=NN=C(N1C2CCN(CC2)C(C)CC(C3=CC=CC=C3)NC(=O)C4CCCCC4)C(C)C
CHEMBL473759 ccr5_human Human Yes 9.3 IC50 = 0.5 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
466 8 1 4 5.2 CC1=NN=C(N1C2CCN(CC2)C(C)CC(C3=CC=CC=C3)NC(=O)C4CCCCC4)C(C)C
CHEMBL1951917 ccr5_human Human No 9.3 IC50 = 0.6 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
638 11 0 7 4.3 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC(=CC=C3)Cl)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL1951917 ccr5_human Human No 9.3 IC50 = 0.6 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
638 11 0 7 4.3 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC(=CC=C3)Cl)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL500631 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
555 11 2 5 4.6 CCC1=C(N=C(N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(CC6CCC6)C(=O)O
CHEMBL500631 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
555 11 2 5 4.6 CCC1=C(N=C(N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(CC6CCC6)C(=O)O
CHEMBL2112558 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
573 11 2 6 4.7 CCC1=C(N=C(N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(CC6CCC6)C(=O)O
CHEMBL500631 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
555 11 2 5 4.6 CCC1=C(N=C(N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(CC6CCC6)C(=O)O
CHEMBL472412 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
561 10 2 5 4.8 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=C(N=C(N5)CC6=CC=CC=C6)Cl
CHEMBL1926900 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
594 13 1 7 5.7 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(N=C(C=C3C)Cl)C)C4=CC=C(C=C4)OCCOC
CHEMBL1649925 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
480 7 1 5 2.5 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC=CC=C5)NC(=O)OC)CN(CC2)C(=O)C
CHEMBL195753 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
550 8 1 8 3.5 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=CN=C6N5C=C(C=C6)[N+](=O)[O-]
CHEMBL472412 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
561 10 2 5 4.8 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=C(N=C(N5)CC6=CC=CC=C6)Cl
CHEMBL59511 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
538 6 0 5 4.4 CC1=C(C(=[N+](C=C1)[O-])C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(CC4=CC=CC(=C4)C#N)C5=CC=CC=C5
CHEMBL1926900 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
594 13 1 7 5.7 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(N=C(C=C3C)Cl)C)C4=CC=C(C=C4)OCCOC
CHEMBL1649925 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
480 7 1 5 2.5 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC(C5=CC=CC=C5)NC(=O)OC)CN(CC2)C(=O)C
CHEMBL59511 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
538 6 0 5 4.4 CC1=C(C(=[N+](C=C1)[O-])C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(CC4=CC=CC(=C4)C#N)C5=CC=CC=C5
CHEMBL195753 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
550 8 1 8 3.5 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=CN=C6N5C=C(C=C6)[N+](=O)[O-]
CHEMBL472412 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
561 10 2 5 4.8 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=C(N=C(N5)CC6=CC=CC=C6)Cl
CHEMBL59511 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
538 6 0 5 4.4 CC1=C(C(=[N+](C=C1)[O-])C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(CC4=CC=CC(=C4)C#N)C5=CC=CC=C5
CHEMBL2435853 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
605 8 1 7 2.6 CC1=C(C=CC(=N1)OC2=CC=C(C=C2)C(=O)O)CN3CCC(CC3)N4C(CN(C4=O)C5CCOCC5)C6=CC(=CC=C6)Cl
CHEMBL2112557 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
579 10 2 6 4.9 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=C(N=C(N5)CC6=CC=CC=C6)Cl
CHEMBL367837 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assayInhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assay
597 12 1 5 5.4 CCCN1C(=C(C=N1)CCC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(C6CCCCC6)C(=O)O
CHEMBL352981 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory activity against human CC chemokine receptor 5Inhibitory activity against human CC chemokine receptor 5
583 11 1 5 4.9 CCN1C(=C(C=N1)CCC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(C6CCCCC6)C(=O)O
CHEMBL367700 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
605 13 1 7 4.4 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OCC
CHEMBL408800 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
577 11 2 7 3.7 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)O
CHEMBL172296 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
637 11 1 6 5.7 CCN1C(=CC(=N1)CC2=CC=C(C=C2)C3=CC=CC=C3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(=O)O)C(C)(C)C
CHEMBL369659 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
645 12 1 10 5.2 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OC(F)(F)F
CHEMBL425845 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
639 12 1 7 5.2 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC3=CC=CC=C3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(C)C)C(=O)O
CHEMBL263529 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
603 11 1 6 5.2 CCN1C(=CC(=N1)CC2=CC=C(C=C2)C(C)C)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL176426 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
645 11 1 10 5.3 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC(F)(F)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL173254 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
617 12 1 7 4.6 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC3CCC3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(C)C)C(=O)O
CHEMBL176933 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
659 13 1 10 5.1 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OCC(F)(F)F
CHEMBL262663 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
563 10 2 7 3.3 CCN1C(=CC(=N1)CC2=CC=C(C=C2)O)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL367560 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
627 13 1 9 5.0 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OC(F)F
CHEMBL369494 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
575 10 1 6 4.5 CCN1C(=CC(=N1)CC2=CC=C(C=C2)C)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL368467 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
701 13 1 8 4.9 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)S(=O)(=O)C6=CC=CC=C6
CHEMBL427122 ccr5_human Human No 9.2 IC50 = 0.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
659 12 1 10 5.2 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OCC(F)(F)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL520755 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
541 9 2 5 4.2 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(N5)CC6=CC=CC=C6
CHEMBL520755 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
541 9 2 5 4.2 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(N5)CC6=CC=CC=C6
CHEMBL520755 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
541 9 2 5 4.2 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(N5)CC6=CC=CC=C6
CHEMBL520755 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
541 9 2 5 4.2 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(N5)CC6=CC=CC=C6
CHEMBL1951912 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
622 11 0 8 3.8 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC(=CC=C3)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL1951912 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
622 11 0 8 3.8 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC(=CC=C3)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL1951914 ccr5_human Human Yes 9.2 IC50 = 0.7 Funct
Antagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxisAntagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxis
640 11 0 9 3.9 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC(=CC(=C3)F)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL1951915 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
656 11 0 8 4.4 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC(=CC(=C3)Cl)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL1951914 ccr5_human Human Yes 9.2 IC50 = 0.7 Funct
Antagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxisAntagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxis
640 11 0 9 3.9 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC(=CC(=C3)F)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL1951915 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
656 11 0 8 4.4 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC(=CC(=C3)Cl)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL318406 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
463 10 1 4 4.5 CC(C)C(C(=O)O)N1CC(C(C1)C2=CC=CC=C2)CN3CCC(CC3)CCCC4=CC=CC=C4
CHEMBL1926891 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
536 10 1 6 5.4 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(C=CN=C3Cl)C)C4=CC=C(C=C4)OC
CHEMBL1927010 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
545 10 1 8 5.0 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CC=CC(=N3)C#N)C4=CC=C(C=C4)OC)C)F
CHEMBL318406 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
463 10 1 4 4.5 CC(C)C(C(=O)O)N1CC(C(C1)C2=CC=CC=C2)CN3CCC(CC3)CCCC4=CC=CC=C4
CHEMBL62152 ccr5_macfa Crab-eating macaque Yes 9.2 IC50 = 0.7 Funct
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
482 5 0 3 6.8 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL377914 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsInhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cells
452 9 2 4 4.0 C1CC(C1)C(=O)NC(CCN2CCC(CC2)NC(=O)CC3=CC=C(C=C3)F)C4=CC=CC=C4
CHEMBL1926891 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
536 10 1 6 5.4 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(C=CN=C3Cl)C)C4=CC=C(C=C4)OC
CHEMBL1927010 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
545 10 1 8 5.0 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CC=CC(=N3)C#N)C4=CC=C(C=C4)OC)C)F
CHEMBL2164215 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
561 10 1 6 4.4 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)CC4CCOCC4)C)Cl
CHEMBL62152 ccr5_human Human Yes 9.2 IC50 = 0.7 Funct
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
482 5 0 3 6.8 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL318406 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
463 10 1 4 4.5 CC(C)C(C(=O)O)N1CC(C(C1)C2=CC=CC=C2)CN3CCC(CC3)CCCC4=CC=CC=C4
CHEMBL62152 ccr5_macfa Crab-eating macaque Yes 9.2 IC50 = 0.7 Funct
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
482 5 0 3 6.8 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL318406 ccr5_human Human No 9.2 IC50 = 0.7 Funct
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
463 10 1 4 4.5 CC(C)C(C(=O)O)N1CC(C(C1)C2=CC=CC=C2)CN3CCC(CC3)CCCC4=CC=CC=C4
CHEMBL2435856 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
585 9 1 7 2.4 CCC1=C(C=CC(=N1)OC2=CC=C(C=C2)C(=O)O)CN3CCC(CC3)N4C(CN(C4=O)C5CCOCC5)C6=CC=CC=C6
CHEMBL377914 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsInhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cells
452 9 2 4 4.0 C1CC(C1)C(=O)NC(CCN2CCC(CC2)NC(=O)CC3=CC=C(C=C3)F)C4=CC=CC=C4
CHEMBL2112552 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
565 10 2 6 4.3 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=C(N=C(N5)CC6=CC=CC=C6)Cl
CHEMBL172322 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
605 10 1 8 3.9 CCN1C(=CC(=N1)CC2=CC3=C(C=C2)OCO3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(=O)O)C(C)(C)C
CHEMBL435554 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
591 11 1 7 4.1 CCN1C(=CC(=N1)CC2=CC(=CC=C2)OC)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL173308 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
623 13 1 8 4.5 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC(=C(C=C5)OCC)F
CHEMBL175394 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
645 13 1 7 5.6 CCCOC1=CC=C(C=C1)CC2=NN(C(=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O)CC
CHEMBL177648 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
667 14 1 7 5.5 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OCC6=CC=CC=C6
CHEMBL177033 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
631 12 1 7 5.0 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC3CCC3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(=O)O)C(C)(C)C
CHEMBL349974 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
623 12 1 8 4.5 CCN1C(=CC(=N1)CC2=CC(=C(C=C2)OCC)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL368204 ccr5_human Human No 9.2 IC50 = 0.7 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
619 12 1 7 4.9 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC(C)C)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL2112560 ccr5_human Human No 9.1 IC50 = 0.7 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
513 10 2 5 3.3 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(N5)CC6=CC=CC=C6
CHEMBL432360 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
620 13 1 7 5.1 CN(CC(CCN1CCC(CC1)N(CC=C)C(=O)NCC2=CC=C(C=C2)[N+](=O)[O-])C3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4
CHEMBL2282506 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
606 12 1 7 5.1 CN(CC(CCN1CCC(CC1)N(CC=C)C(=O)NC2=CC=C(C=C2)[N+](=O)[O-])C3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4
CHEMBL211866 ccr5_human Human Yes 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
597 11 0 6 4.5 CCN(C1CCN(CC1)CCC(C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)C)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL471251 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
572 11 1 6 5.5 CCC1=C(SC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(CC6CCC6)C(=O)O
CHEMBL211866 ccr5_human Human Yes 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
597 11 0 6 4.5 CCN(C1CCN(CC1)CCC(C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)C)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL471251 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
572 11 1 6 5.5 CCC1=C(SC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(CC6CCC6)C(=O)O
CHEMBL2112553 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
590 11 1 7 5.6 CCC1=C(SC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(CC6CCC6)C(=O)O
CHEMBL471251 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
572 11 1 6 5.5 CCC1=C(SC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(CC6CCC6)C(=O)O
CHEMBL2282509 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
621 15 1 7 4.9 CCCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)OCC4=CC=CC(=C4)C(=O)N
CHEMBL172854 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
561 10 1 6 4.1 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL101961 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
513 10 2 5 3.4 C1CN(CCC1(CCCC2=CC=CC=C2)O)CC3CN(CC3C4=CC=CC=C4)C(C5=CC=CC=C5)C(=O)O
CHEMBL281607 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
525 11 1 6 5.4 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCCC5=CC=C(C=C5)F
CHEMBL471909 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
531 11 1 7 4.6 CC(C)CC(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)CCSC4=CC=C(C=C4)F
CHEMBL511634 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
542 9 1 6 4.5 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CC(=NO5)CC6=CC=CC=C6
CHEMBL1926901 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
585 13 1 8 4.8 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(C=C(N=C3C)C#N)C)C4=CC=C(C=C4)OCCOC
CHEMBL193822 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
581 9 1 6 5.3 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=CN=C6N5C=C(C=C6)C7=CC=CC=C7
CHEMBL172854 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
561 10 1 6 4.1 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL101961 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
513 10 2 5 3.4 C1CN(CCC1(CCCC2=CC=CC=C2)O)CC3CN(CC3C4=CC=CC=C4)C(C5=CC=CC=C5)C(=O)O
CHEMBL281607 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
525 11 1 6 5.4 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCCC5=CC=C(C=C5)F
CHEMBL471909 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
531 11 1 7 4.6 CC(C)CC(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)CCSC4=CC=C(C=C4)F
CHEMBL511634 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
542 9 1 6 4.5 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CC(=NO5)CC6=CC=CC=C6
CHEMBL255644 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
524 5 0 5 5.2 CC1(CCN(CC1)C(=O)C2=C(C=NC=C2Cl)Cl)N3CCC(CC3)N(C4=CC=CC=C4)C5=CN=CC=C5
CHEMBL255856 ccr5_macfa Crab-eating macaque No 9.1 IC50 = 0.8 Funct
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
484 5 0 5 4.7 CC1=C(C(=NC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CN=CC=C5
CHEMBL207487 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
645 10 0 7 4.6 CS(=O)(=O)C1=CC=C(C=C1)CC2CCN(CC2)CCCN(C3=CC(=C(C=C3)Cl)Cl)C(=O)C4CCN(CC4)S(=O)(=O)C
CHEMBL281607 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
525 11 1 6 5.4 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCCC5=CC=C(C=C5)F
CHEMBL281176 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
517 10 1 7 4.3 CC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)CCSC4=CC=C(C=C4)F
CHEMBL328260 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Ability to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesAbility to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
589 10 0 6 6.0 C=CCN(C1CCN(CC1)CC2CN(CC2C3=CC=CC=C3)C(=O)C4CCCCC4)C(=O)OCC5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL1926901 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
585 13 1 8 4.8 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(C=C(N=C3C)C#N)C)C4=CC=C(C=C4)OCCOC
CHEMBL2435909 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
582 9 1 5 4.6 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)CC4CCOCC4)C5=CC=CC=C5)C)Cl
CHEMBL2435864 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
575 9 1 5 4.5 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)CC4=CC=NC=C4)C5=CC=CC=C5)C)Cl
CHEMBL2164201 ccr5_human Human Yes 9.1 IC50 = 0.8 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
552 10 1 7 3.5 CC1=C(C(=NC(=C1)C#N)C)C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)CC4CCOCC4
CHEMBL58897 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
474 4 1 6 6.0 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)NC4=CC=C(C=C4)C(F)(F)F
CHEMBL275998 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
554 12 1 9 3.7 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CCC4)C(=O)O)C5=NC=CC(=N5)OC
CHEMBL328297 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
617 10 0 6 6.2 C=CCN(C1CCN(CC1)CC2CN(CC2C3=CC=CC=C3)C(=O)C4=CC=CC=C4Cl)C(=O)OCC5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL193822 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
581 9 1 6 5.3 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=CN=C6N5C=C(C=C6)C7=CC=CC=C7
CHEMBL172854 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
561 10 1 6 4.1 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL435538 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
561 11 1 6 4.1 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=CC=C5
CHEMBL328297 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
617 10 0 6 6.2 C=CCN(C1CCN(CC1)CC2CN(CC2C3=CC=CC=C3)C(=O)C4=CC=CC=C4Cl)C(=O)OCC5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL172854 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
561 10 1 6 4.1 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL101961 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
513 10 2 5 3.4 C1CN(CCC1(CCCC2=CC=CC=C2)O)CC3CN(CC3C4=CC=CC=C4)C(C5=CC=CC=C5)C(=O)O
CHEMBL281607 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
525 11 1 6 5.4 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCCC5=CC=C(C=C5)F
CHEMBL471909 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
531 11 1 7 4.6 CC(C)CC(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)CCSC4=CC=C(C=C4)F
CHEMBL511634 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
542 9 1 6 4.5 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CC(=NO5)CC6=CC=CC=C6
CHEMBL255644 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
524 5 0 5 5.2 CC1(CCN(CC1)C(=O)C2=C(C=NC=C2Cl)Cl)N3CCC(CC3)N(C4=CC=CC=C4)C5=CN=CC=C5
CHEMBL255856 ccr5_macfa Crab-eating macaque No 9.1 IC50 = 0.8 Funct
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
484 5 0 5 4.7 CC1=C(C(=NC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CN=CC=C5
CHEMBL101961 ccr5_human Human No 9.1 IC50 = 0.8 Funct
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
513 10 2 5 3.4 C1CN(CCC1(CCCC2=CC=CC=C2)O)CC3CN(CC3C4=CC=CC=C4)C(C5=CC=CC=C5)C(=O)O
CHEMBL310106 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
655 15 1 7 5.6 CCCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC(=CC=C3)Cl)C(=O)OCC4=CC=CC(=C4)C(=O)N
CHEMBL207487 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
645 10 0 7 4.6 CS(=O)(=O)C1=CC=C(C=C1)CC2CCN(CC2)CCCN(C3=CC(=C(C=C3)Cl)Cl)C(=O)C4CCN(CC4)S(=O)(=O)C
CHEMBL435709 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory activity against human CC chemokine receptor 5Inhibitory activity against human CC chemokine receptor 5
542 9 1 6 4.4 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=C(C=NO5)CC6=CC=CC=C6
CHEMBL172854 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
561 10 1 6 4.1 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL172013 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
631 11 1 10 4.9 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC(F)(F)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL172327 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
659 14 1 7 6.0 CCCCOC1=CC=C(C=C1)CC2=NN(C(=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O)CC
CHEMBL176624 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
619 13 1 7 4.8 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OC(C)C
CHEMBL355809 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
619 13 1 7 5.0 CCCOC1=CC=C(C=C1)CC2=NN(C(=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C)CC
CHEMBL175424 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
633 14 1 7 5.3 CCCCOC1=CC=C(C=C1)CC2=NN(C(=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C)CC
CHEMBL177204 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
619 12 1 7 4.7 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC(C)(C)C)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL177168 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
633 15 1 7 5.3 CCCCOC1=CC=C(C=C1)CC2=NN(C(=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)CC)C(=O)O)CC
CHEMBL263787 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
605 13 1 7 4.4 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC(=CC=C5)OCC
CHEMBL354413 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
727 12 1 8 5.5 CCN1C(=CC(=N1)CC2=CC=C(C=C2)S(=O)(=O)C3=CC=CC=C3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C7CCCCC7)C(=O)O
CHEMBL366492 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
602 11 1 8 3.4 CCN1C(=CC(=N1)CC2=CC(=C(C=C2)OC)C#N)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL366742 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
617 12 1 6 5.7 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)C(C)(C)C
CHEMBL369278 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
605 13 1 7 4.6 CCCOC1=CC=C(C=C1)CC2=NN(C(=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O)CC
CHEMBL328260 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
589 10 0 6 6.0 C=CCN(C1CCN(CC1)CC2CN(CC2C3=CC=CC=C3)C(=O)C4CCCCC4)C(=O)OCC5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL328297 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
617 10 0 6 6.2 C=CCN(C1CCN(CC1)CC2CN(CC2C3=CC=CC=C3)C(=O)C4=CC=CC=C4Cl)C(=O)OCC5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL327241 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsInhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cells
633 10 0 6 6.9 C=CCN(C1CCN(CC1)CC2CN(CC2C3=CC=CC=C3)C(=O)C4=CC=CC5=CC=CC=C54)C(=O)OCC6=CC=C(C=C6)[N+](=O)[O-]
CHEMBL435886 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
573 8 1 9 4.5 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=CN=C6N5C=C(C=C6)C(F)(F)F
CHEMBL522259 ccr5_human Human Yes 9.1 IC50 = 0.8 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
502 8 1 6 5.0 CC1=NN=C(N1C2CCN(CC2)C(C)CC(C3=CC=CC=C3)NC(=O)C4CCC(CC4)(F)F)C(C)C
CHEMBL193440 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
543 10 1 5 4.4 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCN5C=NC6=CC=CC=C65
CHEMBL522259 ccr5_human Human Yes 9.1 IC50 = 0.8 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
502 8 1 6 5.0 CC1=NN=C(N1C2CCN(CC2)C(C)CC(C3=CC=CC=C3)NC(=O)C4CCC(CC4)(F)F)C(C)C
CHEMBL193440 ccr5_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
543 10 1 5 4.4 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCCN5C=NC6=CC=CC=C65
CHEMBL449758 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
556 11 1 6 4.9 CCC1=C(OC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(CC6CCC6)C(=O)O
CHEMBL193988 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
539 8 1 6 4.3 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=CN=C6N5C=C(C=C6)Cl
CHEMBL449758 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
556 11 1 6 4.9 CCC1=C(OC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(CC6CCC6)C(=O)O
CHEMBL193988 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
539 8 1 6 4.3 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=CN=C6N5C=C(C=C6)Cl
CHEMBL449758 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
556 11 1 6 4.9 CCC1=C(OC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(CC6CCC6)C(=O)O
CHEMBL2112556 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
574 11 1 7 5.0 CCC1=C(OC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(CC6CCC6)C(=O)O
CHEMBL435727 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
575 12 1 6 4.4 CCC(CC)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=CC=C5
CHEMBL470510 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
563 11 1 8 3.4 CC(C)CC(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)CCS(=O)(=O)C4=CC=C(C=C4)F
CHEMBL444497 ccr5_human Human Yes 9.1 IC50 = 0.9 Funct
Displacement of [125I]MIP-1beta from CCR5 expressed in CHO cell membraneDisplacement of [125I]MIP-1beta from CCR5 expressed in CHO cell membrane
595 9 0 6 7.3 CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(C6=CC=C(C=C6)F)C(=O)OC)C7=CC=CC=C7
CHEMBL435727 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
575 12 1 6 4.4 CCC(CC)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=CC=C5
CHEMBL470510 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
563 11 1 8 3.4 CC(C)CC(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)CCS(=O)(=O)C4=CC=C(C=C4)F
CHEMBL255856 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
484 5 0 5 4.7 CC1=C(C(=NC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CN=CC=C5
CHEMBL20602 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
549 10 1 8 3.0 CC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)CCS(=O)(=O)C4=CC=C(C=C4)F
CHEMBL2435907 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
552 8 1 4 5.3 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)C4CCCC4)C5=CC=CC=C5)C)Cl
CHEMBL2164218 ccr5_human Human Yes 9.1 IC50 = 0.9 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
477 8 1 5 3.9 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)C)C)Cl
CHEMBL174457 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
561 11 1 6 4.1 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=CC=C5
CHEMBL435727 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
575 12 1 6 4.4 CCC(CC)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=CC=C5
CHEMBL444497 ccr5_human Human Yes 9.1 IC50 = 0.9 Funct
Displacement of [125I]MIP-1beta from CCR5 expressed in CHO cell membraneDisplacement of [125I]MIP-1beta from CCR5 expressed in CHO cell membrane
595 9 0 6 7.3 CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(C6=CC=C(C=C6)F)C(=O)OC)C7=CC=CC=C7
CHEMBL435727 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
575 12 1 6 4.4 CCC(CC)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=CC=C5
CHEMBL470510 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
563 11 1 8 3.4 CC(C)CC(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)CCS(=O)(=O)C4=CC=C(C=C4)F
CHEMBL255856 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
484 5 0 5 4.7 CC1=C(C(=NC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CN=CC=C5
CHEMBL2435907 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
552 8 1 4 5.3 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)C4CCCC4)C5=CC=CC=C5)C)Cl
CHEMBL2435912 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
572 8 1 5 5.5 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)C4CCCCC4)C5=CSC=C5)C)Cl
CHEMBL2435844 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
608 8 1 8 2.1 C1CN(CCC1N2C(CN(C2=O)C3CCOCC3)C4=CC(=CC=C4)Cl)CC5=CN=C(N=C5)SC6=CC=C(C=C6)C(=O)O
CHEMBL2434978 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
573 8 1 7 2.1 C1CN(CCC1N2C(CN(C2=O)C3CCOCC3)C4=CC=CC=C4)CC5=CN=C(C=C5)SC6=CC=C(C=C6)C(=O)O
CHEMBL2435859 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
580 9 1 4 6.4 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)CC4CCCCC4)C5=CC=CC=C5)C)Cl
CHEMBL2435845 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
605 8 2 8 2.0 CC1=NC(=NC=C1CN2CCC(CC2)N3C(CN(C3=O)C4CCOCC4)C5=CC(=CC=C5)Cl)NC6=CC=C(C=C6)C(=O)O
CHEMBL176604 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
605 12 1 7 4.4 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OCC)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL171468 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
586 11 1 7 3.8 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=CC(=C5)C#N
CHEMBL174904 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
616 11 1 8 3.8 CCN1C(=CC(=N1)CC2=CC(=C(C=C2)OC)C#N)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL366600 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
621 10 1 6 5.4 CCN1C(=CC(=N1)CC2=CC=C(C=C2)Cl)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O
CHEMBL367102 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
605 13 1 7 4.4 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC(=CC=C5)OCC
CHEMBL368332 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
623 10 1 8 4.9 CCN1C(=CC(=N1)CC2=CC(=CC(=C2)F)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O
CHEMBL435538 ccr5_human Human No 9.1 IC50 = 0.9 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
561 11 1 6 4.1 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=CC=C5
CHEMBL461690 ccr5_human Human Yes 9.0 IC50 = 0.9 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
494 10 1 4 5.0 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)CC4=CC=C(C=C4)F
CHEMBL461690 ccr5_human Human Yes 9.0 IC50 = 0.9 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
494 10 1 4 5.0 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)CC4=CC=C(C=C4)F
CHEMBL3085310 ccr5_human Human Yes 9.0 IC50 = 1.0 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
684 17 1 8 6.5 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=NN=CN5CCC)CCC
CHEMBL3085310 ccr5_human Human Yes 9.0 IC50 = 1.0 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
684 17 1 8 6.5 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=NN=CN5CCC)CCC
CHEMBL3109175 ccr5_human Human No 9.0 IC50 = 1.0 Funct
Antagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 JR-FL-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assayAntagonist activity against CCR5 receptor in human TZM-bl cells assessed as inhibition of HIV-1 JR-FL-induced cell-cell fusion between viral envelope protein expressing human HEK293 cells to TZM-bl cells after 48 hrs by luciferase reporter gene assay
653 18 1 8 9.0 CC1=NN=C(N1C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)CCCCCCCCCCN=[N+]=[N-]
CHEMBL1926904 ccr5_human Human No 9.0 IC50 = 1.0 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
584 12 2 8 3.9 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(C=C(N=C3C)C#N)C)C4=CC=C(C=C4)OCC(=O)N
CHEMBL1926904 ccr5_human Human No 9.0 IC50 = 1.0 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
584 12 2 8 3.9 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(C=C(N=C3C)C#N)C)C4=CC=C(C=C4)OCC(=O)N
CHEMBL593042 ccr5_human Human No 9.0 IC50 = 1 Funct
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
548 6 0 7 3.7 CC1=C(C(=NC(=C1)C#N)C)C(=O)N2CC3CN(CC3C2)CCC4(CN(C4)C(=O)C5CC(C5)(F)F)C6=CC=CC=C6
CHEMBL481068 ccr5_human Human No 9.0 IC50 = 1 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
486 6 0 3 5.0 CC1=C(C(=CC=C1)C)C(=O)N2C3CCC2CC(C3)N4CCC(C4)N(CC5=CC=CC=C5)C(=O)C6CC6
CHEMBL471623 ccr5_human Human Yes 9.0 IC50 = 1 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
460 6 0 3 4.3 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)N3CCC(C3)N(CC4=CC=CC=C4)C(=O)C5CC5
CHEMBL2113088 ccr5_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
506 8 1 7 2.6 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=CN=C6N5C=CN=C6
CHEMBL379082 ccr5_human Human Yes 9.0 IC50 = 1 Funct
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
631 11 0 6 5.1 CCN(C1CCN(CC1)CCC(C2=CC=C(C=C2)S(=O)(=O)C)C3=CC(=CC=C3)Cl)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL3084499 ccr5_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]MIP-1beta from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1beta from human CCR5 expressed in CHO cells
547 6 0 3 7.1 CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C(C)(C)C)C6=CC(=CC=C6)Cl
CHEMBL480890 ccr5_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
560 11 1 6 5.2 CCC1=C(SC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(CC(C)C)C(=O)O
CHEMBL99788 ccr5_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
533 11 1 5 6.8 COC(=O)C(C1CCCCC1)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=CC=C5)O
CHEMBL255645 ccr5_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
540 5 0 5 4.2 CC1(CCN(CC1)C(=O)C2=C(C=[N+](C=C2Cl)[O-])Cl)N3CCC(CC3)N(C4=CC=CC=C4)C5=CN=CC=C5
CHEMBL61424 ccr5_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
484 5 0 5 5.2 CC1=C(C(=NC=N1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL204821 ccr5_human Human No 9.0 IC50 = 1 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
683 17 1 7 7.1 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CC(C)C
CHEMBL317710 ccr5_human Human Yes 9.0 IC50 = 1 Funct
Ability to inhibit binding of [125I]-MIP-1 alpha to C-C chemokine receptor type 5 in Chinese hamster ovary (CHO) cell membranesAbility to inhibit binding of [125I]-MIP-1 alpha to C-C chemokine receptor type 5 in Chinese hamster ovary (CHO) cell membranes
475 9 1 3 6.8 C1CCC(CC1)CN2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=CC=C5)O
CHEMBL593042 ccr5_human Human No 9.0 IC50 = 1 Funct
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
548 6 0 7 3.7 CC1=C(C(=NC(=C1)C#N)C)C(=O)N2CC3CN(CC3C2)CCC4(CN(C4)C(=O)C5CC(C5)(F)F)C6=CC=CC=C6
CHEMBL481068 ccr5_human Human No 9.0 IC50 = 1 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
486 6 0 3 5.0 CC1=C(C(=CC=C1)C)C(=O)N2C3CCC2CC(C3)N4CCC(C4)N(CC5=CC=CC=C5)C(=O)C6CC6
CHEMBL471623 ccr5_human Human Yes 9.0 IC50 = 1 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
460 6 0 3 4.3 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)N3CCC(C3)N(CC4=CC=CC=C4)C(=O)C5CC5
CHEMBL61424 ccr5_human Human No 9.0 IC50 = 1 Funct
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
484 5 0 5 5.2 CC1=C(C(=NC=N1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2113088 ccr5_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
506 8 1 7 2.6 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)C5=CN=C6N5C=CN=C6
CHEMBL420465 ccr5_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
557 11 2 6 6.3 C1CCC(CC1)CN2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=C(C=C5)CC6=NNN=N6)O
CHEMBL379082 ccr5_human Human Yes 9.0 IC50 = 1 Funct
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
631 11 0 6 5.1 CCN(C1CCN(CC1)CCC(C2=CC=C(C=C2)S(=O)(=O)C)C3=CC(=CC=C3)Cl)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL3084499 ccr5_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]MIP-1beta from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1beta from human CCR5 expressed in CHO cells
547 6 0 3 7.1 CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C(C)(C)C)C6=CC(=CC=C6)Cl
CHEMBL480890 ccr5_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
560 11 1 6 5.2 CCC1=C(SC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(CC(C)C)C(=O)O
CHEMBL99788 ccr5_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
533 11 1 5 6.8 COC(=O)C(C1CCCCC1)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=CC=C5)O
CHEMBL255645 ccr5_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
540 5 0 5 4.2 CC1(CCN(CC1)C(=O)C2=C(C=[N+](C=C2Cl)[O-])Cl)N3CCC(CC3)N(C4=CC=CC=C4)C5=CN=CC=C5
CHEMBL61424 ccr5_human Human No 9.0 IC50 = 1 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
484 5 0 5 5.2 CC1=C(C(=NC=N1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL103813 ccr5_human Human No 9.0 IC50 = 1 Funct
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
505 10 2 4 6.2 C1CCC(CC1)C(CO)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=CC=C5)O
CHEMBL103343 ccr5_human Human No 9.0 IC50 = 1 Funct
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
505 10 2 4 6.2 C1CCC(CC1)C(CO)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=CC=C5)O
CHEMBL99788 ccr5_human Human No 9.0 IC50 = 1 Funct
In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.
533 11 1 5 6.8 COC(=O)C(C1CCCCC1)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=CC=C5)O
CHEMBL2435864 ccr5_human Human No 9.0 IC50 = 1 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
575 9 1 5 4.5 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)CC4=CC=NC=C4)C5=CC=CC=C5)C)Cl
CHEMBL2435866 ccr5_human Human No 9.0 IC50 = 1 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
618 10 2 6 2.8 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)CC4=CC=C(C=C4)C(=O)O)C5=CC=CC=C5)C)Cl
CHEMBL2112555 ccr5_human Human No 9.0 IC50 = 1 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
564 10 1 7 5.0 CCC1=C(SC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL368183 ccr5_human Human No 9.0 IC50 = 1 Funct
Inhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assayInhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assay
569 10 1 5 4.6 CN1C(=C(C=N1)CCC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(C6CCCCC6)C(=O)O
CHEMBL204821 ccr5_human Human No 9.0 IC50 = 1 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
683 17 1 7 7.1 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CC(C)C
CHEMBL93139 ccr5_human Human No 9.0 IC50 = 1 Funct
Inhibitory concentration against human C-C chemokine receptor type 5 in CHO cells with [125I]-MIP-1 alpha radioligandInhibitory concentration against human C-C chemokine receptor type 5 in CHO cells with [125I]-MIP-1 alpha radioligand
635 14 0 8 6.2 CC(CCN1CCC(CC1)N(CC=C)C(=O)OCC2=CC=C(C=C2)[N+](=O)[O-])(CN(C)S(=O)(=O)C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL172079 ccr5_human Human No 9.0 IC50 = 1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
631 12 1 7 5.1 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OCC)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O
CHEMBL172820 ccr5_human Human No 9.0 IC50 = 1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
586 10 1 7 3.8 CCN1C(=CC(=N1)CC2=CC=CC(=C2)C#N)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL176337 ccr5_human Human No 9.0 IC50 = 1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
603 12 1 7 4.2 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC3CC3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(C)C)C(=O)O
CHEMBL177205 ccr5_human Human No 9.0 IC50 = 1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
605 10 1 7 4.8 CCN1C(=CC(=N1)CC2=CC(=CC=C2)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O
CHEMBL367383 ccr5_human Human No 9.0 IC50 = 1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
591 12 1 7 4.0 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OCC)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL368309 ccr5_human Human No 9.0 IC50 = 1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
633 15 1 7 5.3 CCCCOC1=CC=C(C=C1)CC2=NN(C(=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)CC)C(=O)O)CC
CHEMBL1172048 ccr5_human Human Yes 9.0 IC50 = 1.1 Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
613 9 2 7 4.9 C=CCN(C1CCN(CC1)CC2CN(CC2(C3=CC=CC=C3)O)C(=O)C4CCCC4)C(=O)NCC5=CC=C(C=C5)C(F)(F)F
CHEMBL1172043 ccr5_human Human Yes 9.0 IC50 = 1.1 Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
580 10 1 5 5.2 C=CCN(C1CCN(CC1)CC2CN(CC2(C3=CC=CC=C3)O)C(=O)C4CCCC4)C(=O)OCC5=CC=C(C=C5)Cl
CHEMBL1172048 ccr5_human Human Yes 9.0 IC50 = 1.1 Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
613 9 2 7 4.9 C=CCN(C1CCN(CC1)CC2CN(CC2(C3=CC=CC=C3)O)C(=O)C4CCCC4)C(=O)NCC5=CC=C(C=C5)C(F)(F)F
CHEMBL1172043 ccr5_human Human Yes 9.0 IC50 = 1.1 Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
580 10 1 5 5.2 C=CCN(C1CCN(CC1)CC2CN(CC2(C3=CC=CC=C3)O)C(=O)C4CCCC4)C(=O)OCC5=CC=C(C=C5)Cl
CHEMBL1688239 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
527 3 0 5 4.1 CC1CN(CCN1C2CCC3=C2C=CC(=C3)Br)C4(CCN(CC4)C(=O)C5=C(N=CN=C5C)C)C
CHEMBL382435 ccr5_human Human Yes 9.0 IC50 = 1.1 Funct
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
649 11 0 7 5.2 CCN(C1CCN(CC1)CCC(C2=CC=C(C=C2)S(=O)(=O)C)C3=CC(=CC(=C3)Cl)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL1951906 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
604 11 0 7 3.7 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC=CC=C3)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL255429 ccr5_macfa Crab-eating macaque No 9.0 IC50 = 1.1 Funct
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
483 5 0 4 5.7 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CN=CC=C5
CHEMBL58387 ccr5_macfa Crab-eating macaque No 9.0 IC50 = 1.1 Funct
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
483 5 0 4 5.8 CC1=C(C(=NC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL280344 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
589 10 1 8 4.0 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)CCS(=O)(=O)C5=CC=C(C=C5)F
CHEMBL1688239 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
527 3 0 5 4.1 CC1CN(CCN1C2CCC3=C2C=CC(=C3)Br)C4(CCN(CC4)C(=O)C5=C(N=CN=C5C)C)C
CHEMBL58897 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
474 4 1 6 6.0 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)NC4=CC=C(C=C4)C(F)(F)F
CHEMBL58387 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Antagonistic activity against monkey C-C chemokine receptor type 5.Antagonistic activity against monkey C-C chemokine receptor type 5.
483 5 0 4 5.8 CC1=C(C(=NC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL137327 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
536 11 1 8 3.3 C1CC(C1)CC(C(=O)O)N2CC(C(C2)C3=CC(=CC=C3)F)CN4CCC(CC4)N(CC5CC5)C6=NC=CC=N6
CHEMBL382435 ccr5_human Human Yes 9.0 IC50 = 1.1 Funct
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
649 11 0 7 5.2 CCN(C1CCN(CC1)CCC(C2=CC=C(C=C2)S(=O)(=O)C)C3=CC(=CC(=C3)Cl)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL1951906 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
604 11 0 7 3.7 CCN(C1CCN(CC1)CCC(C2CCN(CC2)S(=O)(=O)C)C3=CC=CC=C3)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL255429 ccr5_macfa Crab-eating macaque No 9.0 IC50 = 1.1 Funct
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
483 5 0 4 5.7 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CN=CC=C5
CHEMBL58387 ccr5_macfa Crab-eating macaque No 9.0 IC50 = 1.1 Funct
Displacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cellsDisplacement of radiolabeled MIP-1alpha from cynomolgus monkey CCR5 expressed in CHO cells
483 5 0 4 5.8 CC1=C(C(=NC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2435909 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
582 9 1 5 4.6 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)CC4CCOCC4)C5=CC=CC=C5)C)Cl
CHEMBL2435858 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
570 8 1 6 3.6 CC1=C(C=CC(=N1)OC2=CC=C(C=C2)C(=O)N)CN3CCC(CC3)N4C(CN(C4=O)C5CCOCC5)C6=CC=CC=C6
CHEMBL2435854 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
585 8 1 7 2.3 CC1=CC=CC(=C1)C2CN(C(=O)N2C3CCN(CC3)CC4=C(N=C(C=C4)OC5=CC=C(C=C5)C(=O)O)C)C6CCOCC6
CHEMBL2112554 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
544 8 1 6 4.8 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CSC(=N5)C6=CC=CC=C6
CHEMBL173019 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
577 10 2 7 3.7 CCN1C(=CC(=N1)CC2=CC=C(C=C2)O)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL369632 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
617 11 1 7 4.7 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O
CHEMBL170829 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
565 10 1 7 3.8 CCN1C(=CC(=N1)CC2=CC=C(C=C2)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL369040 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
701 13 1 8 4.9 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)S(=O)(=O)C6=CC=CC=C6
CHEMBL176391 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
583 10 1 8 3.9 CCN1C(=CC(=N1)CC2=CC(=C(C=C2)F)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL173492 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
567 10 1 6 5.2 CCN1C(=CC(=N1)CC2CCCCC2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL367489 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
605 10 1 7 4.8 CCN1C(=CC(=N1)CC2=CC=C(C=C2)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O
CHEMBL367916 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
701 12 1 8 4.9 CCN1C(=CC(=N1)CC2=CC=C(C=C2)S(=O)(=O)C3=CC=CC=C3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(=O)O)C(C)(C)C
CHEMBL369277 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
619 14 1 7 4.9 CCCOC1=CC=C(C=C1)CC2=NN(C(=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)CC)C(=O)O)CC
CHEMBL367988 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
667 13 1 7 5.6 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OCC3=CC=CC=C3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(=O)O)C(C)(C)C
CHEMBL440554 ccr5_human Human No 9.0 IC50 = 1.1 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
645 12 1 10 5.2 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OC(F)(F)F
CHEMBL173095 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
573 11 1 6 4.4 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(CC6CCC6)C(=O)O
CHEMBL175327 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
559 11 1 6 3.8 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(CC6CC6)C(=O)O
CHEMBL353331 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
569 10 1 5 4.6 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(C6CCCCC6)C(=O)O
CHEMBL471542 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
542 9 1 6 4.5 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=NOC(=C5)CC6=CC=CC=C6
CHEMBL1688240 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
516 3 0 8 4.3 CC1CN(CCN1C2CCC3=C2C=CC(=C3)C(F)(F)F)C4(CCN(CC4)C(=O)C5=C(N=CN=C5C)C)C
CHEMBL173095 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
573 11 1 6 4.4 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(CC6CCC6)C(=O)O
CHEMBL175327 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
559 11 1 6 3.8 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(CC6CC6)C(=O)O
CHEMBL353331 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
569 10 1 5 4.6 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(C6CCCCC6)C(=O)O
CHEMBL471542 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
542 9 1 6 4.5 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=NOC(=C5)CC6=CC=CC=C6
CHEMBL1271208 ccr5_human Human Yes 8.9 IC50 = 1.2 Funct
Inhibition of CCR5 by cell-cell fusion inhibition assayInhibition of CCR5 by cell-cell fusion inhibition assay
550 7 0 7 3.4 CC1=C(C(=NC(=C1)C#N)C)C(=O)N2CC3CN(CC3C2)CCC(C4CCN(CC4)S(=O)(=O)C)C5=CC=CC=C5
CHEMBL207182 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cellsInhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells
549 8 0 4 5.7 CC(=O)N1CCC(CC1)C(=O)N(CCCN2CCC(CC2)CC3=CC=C(C=C3)F)C4=CC(=C(C=C4)Cl)Cl
CHEMBL2435862 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
589 9 1 5 4.8 CC1=C(C=NC=C1)CN2CC(N(C2=O)C3CCN(CC3)C(C)CCNC(=O)C4=C(N=C(C=C4C)Cl)C)C5=CC=CC=C5
CHEMBL1688240 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxisAntagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
516 3 0 8 4.3 CC1CN(CCN1C2CCC3=C2C=CC(=C3)C(F)(F)F)C4(CCN(CC4)C(=O)C5=C(N=CN=C5C)C)C
CHEMBL2164213 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
508 10 1 7 4.6 CC1=C(C(=NC=N1)C)C(=O)NCCC(C)N2CCC(CC2)N(CC3=CSC=C3)C4=CC=C(C=C4)OC
CHEMBL343745 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
592 11 1 11 4.3 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CCC4)C(=O)O)C5=NC=CC(=N5)C(F)(F)F
CHEMBL342842 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
524 11 1 8 3.4 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CCC4)C(=O)O)C5=NC=NC=C5
CHEMBL173095 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
573 11 1 6 4.4 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(CC6CCC6)C(=O)O
CHEMBL175327 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
559 11 1 6 3.8 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(CC6CC6)C(=O)O
CHEMBL353331 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
569 10 1 5 4.6 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(C6CCCCC6)C(=O)O
CHEMBL2203619 ccr5_human Human Yes 8.9 IC50 = 1.2 Funct
Displacement of [125I]MIP-1beta from CCR5 receptorDisplacement of [125I]MIP-1beta from CCR5 receptor
445 7 1 3 4.7 CC1=NC2=CC=CC=C2N1C3(CCN(CC3)CCC(C4=CC=CC=C4)NC(=O)C5CCC5)C
CHEMBL173095 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
573 11 1 6 4.4 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(CC6CCC6)C(=O)O
CHEMBL175327 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
559 11 1 6 3.8 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(CC6CC6)C(=O)O
CHEMBL353331 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
569 10 1 5 4.6 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(C6CCCCC6)C(=O)O
CHEMBL471542 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
542 9 1 6 4.5 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=NOC(=C5)CC6=CC=CC=C6
CHEMBL2435885 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
566 8 1 4 5.9 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)C4CCCCC4)C5=CC=CC=C5)C)Cl
CHEMBL2435860 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
574 9 1 4 5.5 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)CC4=CC=CC=C4)C5=CC=CC=C5)C)Cl
CHEMBL1271208 ccr5_human Human Yes 8.9 IC50 = 1.2 Funct
Inhibition of CCR5 by cell-cell fusion inhibition assayInhibition of CCR5 by cell-cell fusion inhibition assay
550 7 0 7 3.4 CC1=C(C(=NC(=C1)C#N)C)C(=O)N2CC3CN(CC3C2)CCC(C4CCN(CC4)S(=O)(=O)C)C5=CC=CC=C5
CHEMBL207182 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cellsInhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells
549 8 0 4 5.7 CC(=O)N1CCC(CC1)C(=O)N(CCCN2CCC(CC2)CC3=CC=C(C=C3)F)C4=CC(=C(C=C4)Cl)Cl
CHEMBL173064 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Inhibitory activity against human CC chemokine receptor 5Inhibitory activity against human CC chemokine receptor 5
542 9 1 6 4.4 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=NOC=C5CC6=CC=CC=C6
CHEMBL367787 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Inhibitory activity against human CC chemokine receptor 5Inhibitory activity against human CC chemokine receptor 5
555 10 2 5 4.6 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=C(C=NN5)CCC6=CC=CC=C6
CHEMBL367697 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
619 14 1 7 4.9 CCCOC1=CC=C(C=C1)CC2=NN(C(=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)CC)C(=O)O)CC
CHEMBL170118 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
567 11 1 6 5.1 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5CCCCC5
CHEMBL172806 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
621 12 1 8 4.0 CCN1C(=CC(=N1)CC2=CC(=C(C=C2)OC)OC)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL435347 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
591 12 1 7 4.0 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC(=CC=C5)OC
CHEMBL353331 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Inhibitory concentration to displace [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellInhibitory concentration to displace [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cell
569 10 1 5 4.6 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(C6CCCCC6)C(=O)O
CHEMBL353331 ccr5_human Human No 8.9 IC50 = 1.2 Funct
Inhibitory concentration to displace [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsInhibitory concentration to displace [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
569 10 1 5 4.6 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(C6CCCCC6)C(=O)O
CHEMBL1926902 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
578 13 1 8 5.1 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(N=C(C=C3C)F)C)C4=CC=C(C=C4)OCCOC
CHEMBL481080 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
558 9 1 6 5.1 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CSC(=N5)CC6=CC=CC=C6
CHEMBL401929 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
505 5 0 4 6.3 CC1(CCN(CC1)C(=O)C2=CC=CC3=CC=CC=C32)N4CCC(CC4)N(C5=CC=CC=C5)C6=CN=CC=C6
CHEMBL1926902 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
578 13 1 8 5.1 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(N=C(C=C3C)F)C)C4=CC=C(C=C4)OCCOC
CHEMBL2435860 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
574 9 1 4 5.5 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)CC4=CC=CC=C4)C5=CC=CC=C5)C)Cl
CHEMBL481080 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
558 9 1 6 5.1 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CSC(=N5)CC6=CC=CC=C6
CHEMBL401929 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
505 5 0 4 6.3 CC1(CCN(CC1)C(=O)C2=CC=CC3=CC=CC=C32)N4CCC(CC4)N(C5=CC=CC=C5)C6=CN=CC=C6
CHEMBL2435843 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
584 8 1 6 4.0 CC1=C(C=CC(=N1)OC2=CC=C(C=C2)C(=O)NC)CN3CCC(CC3)N4C(CN(C4=O)C5CCOCC5)C6=CC=CC=C6
CHEMBL2435851 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
591 8 1 7 2.2 C1CN(CCC1N2C(CN(C2=O)C3CCOCC3)C4=CC(=CC=C4)Cl)CC5=CN=C(C=C5)OC6=CC=C(C=C6)C(=O)O
CHEMBL481080 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
558 9 1 6 5.1 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CSC(=N5)CC6=CC=CC=C6
CHEMBL176980 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
633 13 1 7 5.0 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OC(C)(C)C
CHEMBL369822 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
581 10 1 6 4.3 CCN1C(=CC(=N1)CC2=CC=C(C=C2)Cl)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL176571 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
631 13 1 7 4.9 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OC6CCC6
CHEMBL173482 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
586 11 1 7 3.8 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)C#N
CHEMBL176850 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
565 10 1 7 3.8 CCN1C(=CC(=N1)CC2=CC(=CC=C2)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL177156 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
687 12 1 8 4.5 CCN1C(=CC(=N1)CC2=CC=C(C=C2)S(=O)(=O)C3=CC=CC=C3)C4CCN(CC4)CC5CN(CC5C6=CC(=CC=C6)F)C(C(C)C)C(=O)O
CHEMBL352511 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
577 11 1 7 3.7 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL367169 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
586 10 1 7 3.8 CCN1C(=CC(=N1)CC2=CC=C(C=C2)C#N)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL367246 ccr5_human Human No 8.9 IC50 = 1.3 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
586 11 1 7 3.8 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)C#N
CHEMBL1222769 ccr5_human Human Yes 8.9 IC50 = 1.4 Funct
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
631 9 2 8 5.0 C=CCN(C1CCN(CC1)CC2CN(CC2(C3=CC(=CC=C3)F)O)C(=O)C4CCCC4)C(=O)NCC5=CC=C(C=C5)C(F)(F)F
CHEMBL1222769 ccr5_human Human Yes 8.9 IC50 = 1.4 Funct
Inhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS bindingInhibition of human CCR5 expressed in CHO cells assessed as inhibition of RANTES-stimulated [35S]GTPgammaS binding
631 9 2 8 5.0 C=CCN(C1CCN(CC1)CC2CN(CC2(C3=CC(=CC=C3)F)O)C(=O)C4CCCC4)C(=O)NCC5=CC=C(C=C5)C(F)(F)F
CHEMBL1649912 ccr5_human Human Yes 8.9 IC50 = 1.4 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
514 8 1 6 5.7 CC1=NN(C(=N1)C(C)C)C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F
CHEMBL3085107 ccr5_human Human Yes 8.9 IC50 = 1.4 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
514 8 1 6 5.7 CC1=NN(C(=N1)C(C)C)C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F
CHEMBL1649912 ccr5_human Human Yes 8.9 IC50 = 1.4 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
514 8 1 6 5.7 CC1=NN(C(=N1)C(C)C)C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F
CHEMBL3085107 ccr5_human Human Yes 8.9 IC50 = 1.4 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
514 8 1 6 5.7 CC1=NN(C(=N1)C(C)C)C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F
CHEMBL301454 ccr5_human Human No 8.9 IC50 = 1.4 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
496 6 0 3 6.8 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(CC4=CC=CC=C4)C5=CC=CC=C5
CHEMBL207630 ccr5_human Human No 8.9 IC50 = 1.4 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
592 9 0 6 5.1 CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN2CCC(CC2)CC3=CC=C(C=C3)C#N)C4=CC(=C(C=C4)Cl)Cl
CHEMBL3085307 ccr5_human Human Yes 8.9 IC50 = 1.4 Funct
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
683 17 1 7 7.0 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CCC
CHEMBL1649912 ccr5_human Human Yes 8.9 IC50 = 1.4 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
514 8 1 6 5.7 CC1=NN(C(=N1)C(C)C)C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F
CHEMBL3085107 ccr5_human Human Yes 8.9 IC50 = 1.4 Funct
Antagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in HeLa-P4 cells co-expressing CD4 assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat10 cells after 20 hrs by cell-cell fusion assay
514 8 1 6 5.7 CC1=NN(C(=N1)C(C)C)C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F
CHEMBL1649912 ccr5_human Human Yes 8.9 IC50 = 1.4 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
514 8 1 6 5.7 CC1=NN(C(=N1)C(C)C)C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F
CHEMBL3085107 ccr5_human Human Yes 8.9 IC50 = 1.4 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
514 8 1 6 5.7 CC1=NN(C(=N1)C(C)C)C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F
CHEMBL301454 ccr5_human Human No 8.9 IC50 = 1.4 Funct
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
496 6 0 3 6.8 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(CC4=CC=CC=C4)C5=CC=CC=C5
CHEMBL301454 ccr5_human Human No 8.9 IC50 = 1.4 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
496 6 0 3 6.8 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(CC4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2435852 ccr5_human Human No 8.9 IC50 = 1.4 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
571 8 1 7 2.0 CC1=C(C=CC(=N1)OC2=CC=C(C=C2)C(=O)O)CN3CCC(CC3)N4C(CN(C4=O)C5CCOCC5)C6=CC=CC=C6
CHEMBL207630 ccr5_human Human No 8.9 IC50 = 1.4 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
592 9 0 6 5.1 CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN2CCC(CC2)CC3=CC=C(C=C3)C#N)C4=CC(=C(C=C4)Cl)Cl
CHEMBL3085307 ccr5_human Human Yes 8.9 IC50 = 1.4 Funct
Inhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cellsInhibition of replication of R5 HIV1 Ba-L in MOLT4/CCR5 cells
683 17 1 7 7.0 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CCC
CHEMBL368375 ccr5_human Human No 8.9 IC50 = 1.4 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
577 11 2 7 3.7 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)O
CHEMBL1926894 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
536 10 1 6 5.5 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CN=CC=C3)C4=CC=C(C=C4)OC)C)Cl
CHEMBL1688243 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Antagonist activity at CCR5 assessed as inhibition of receptor internalizationAntagonist activity at CCR5 assessed as inhibition of receptor internalization
560 5 0 9 4.2 CCOC1CC2=C(C1N3CCN(CC3C)C4(CCN(CC4)C(=O)C5=C(N=CN=C5C)C)C)C=CC(=C2)C(F)(F)F
CHEMBL174304 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
547 10 1 6 3.7 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL283788 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
569 13 1 8 4.3 COC(=O)C(CCC1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CC4)C(=O)O)C5=CC=C(C=C5)F
CHEMBL283788 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
569 13 1 8 4.3 COC(=O)C(CCC1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CC4)C(=O)O)C5=CC=C(C=C5)F
CHEMBL1926894 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
536 10 1 6 5.5 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CN=CC=C3)C4=CC=C(C=C4)OC)C)Cl
CHEMBL2435885 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
566 8 1 4 5.9 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)C4CCCCC4)C5=CC=CC=C5)C)Cl
CHEMBL2435886 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
566 8 1 4 5.9 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)C4CCCCC4)C5=CC=CC=C5)C)Cl
CHEMBL1688243 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Antagonist activity at CCR5 assessed as inhibition of receptor internalizationAntagonist activity at CCR5 assessed as inhibition of receptor internalization
560 5 0 9 4.2 CCOC1CC2=C(C1N3CCN(CC3C)C4(CCN(CC4)C(=O)C5=C(N=CN=C5C)C)C)C=CC(=C2)C(F)(F)F
CHEMBL343366 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
510 10 1 8 2.9 CCN(C1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CCC4)C(=O)O)C5=NC=CC=N5
CHEMBL174304 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
547 10 1 6 3.7 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL174304 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
547 10 1 6 3.7 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL283788 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
569 13 1 8 4.3 COC(=O)C(CCC1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CC4)C(=O)O)C5=CC=C(C=C5)F
CHEMBL2435855 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
589 8 1 8 2.1 CC1=C(C=CC(=N1)OC2=CC=C(C=C2)C(=O)O)CN3CCC(CC3)N4C(CN(C4=O)C5CCOCC5)C6=CC(=CC=C6)F
CHEMBL82168 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
576 14 0 6 5.8 CN(CC(CCN1CCC(CC1)N(CC=C)C(=O)OCC2=CC=CC=C2)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4
CHEMBL2114183 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
623 14 0 8 5.9 CCCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)OCC4=CC=C(C=C4)[N+](=O)[O-]
CHEMBL421342 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
623 14 0 8 5.9 CCCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)OCC4=CC=C(C=C4)[N+](=O)[O-]
CHEMBL174304 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
547 10 1 6 3.7 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL366494 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
655 10 1 9 5.6 CCN1C(=CC(=N1)CC2=CC=C(C=C2)C(F)(F)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O
CHEMBL172090 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
621 13 1 8 4.0 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC(=C(C=C5)OC)OC
CHEMBL173202 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
623 10 1 8 4.9 CCN1C(=CC(=N1)CC2=C(C=C(C=C2)F)F)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O
CHEMBL368823 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
591 11 1 7 4.1 CCN1C(=CC(=N1)CC2=CC=C(C=C2)OC)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL81926 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
592 14 0 6 6.4 CCCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)OCC4=CC=CC=C4C
CHEMBL421342 ccr5_human Human No 8.8 IC50 = 1.5 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
623 14 0 8 5.9 CCCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)OCC4=CC=C(C=C4)[N+](=O)[O-]
CHEMBL1172625 ccr5_human Human Yes 8.8 IC50 = 1.5 Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
623 11 2 7 3.3 CNS(=O)(=O)C1=CC=C(C=C1)CC(=O)N(CC=C)C2CCN(CC2)CC3CN(CC3(C4=CC=CC=C4)O)C(=O)C5CCCC5
CHEMBL1172625 ccr5_human Human Yes 8.8 IC50 = 1.5 Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
623 11 2 7 3.3 CNS(=O)(=O)C1=CC=C(C=C1)CC(=O)N(CC=C)C2CCN(CC2)CC3CN(CC3(C4=CC=CC=C4)O)C(=O)C5CCCC5
CHEMBL457044 ccr5_human Human Yes 8.8 IC50 = 1.5 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
510 10 1 3 5.5 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)CC4=CC(=CC=C4)Cl
CHEMBL457044 ccr5_human Human Yes 8.8 IC50 = 1.5 Funct
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assayAntagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
510 10 1 3 5.5 CCN(C1CCN(CC1)C(C)CC(C2=CC=CC=C2)NC(=O)C3CCC3)C(=O)CC4=CC(=CC=C4)Cl
CHEMBL1926897 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
520 10 1 7 4.9 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CN=CC=C3)C4=CC=C(C=C4)OC)C)F
CHEMBL1951898 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
659 11 0 11 3.7 CCN(C1CCN(CC1)CCC(C2=CC=CC=C2)N3CCN(CC3)S(=O)(=O)C(F)(F)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL352514 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
541 10 1 5 3.6 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(C6CCC6)C(=O)O
CHEMBL20598 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
541 11 2 7 3.6 CC(CCC1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CC4)C(=O)O)(C5=CC=C(C=C5)F)O
CHEMBL480504 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
514 10 1 6 3.5 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(O5)CC6=CC=CC=C6
CHEMBL21167 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
535 10 1 6 4.3 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)CCC(=O)C5=CC=C(C=C5)F
CHEMBL20598 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneAbility to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membrane
541 11 2 7 3.6 CC(CCC1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CC4)C(=O)O)(C5=CC=C(C=C5)F)O
CHEMBL1926897 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
520 10 1 7 4.9 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N(CC3=CN=CC=C3)C4=CC=C(C=C4)OC)C)F
CHEMBL138437 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
538 10 1 8 3.8 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(C4CCCCC4)C(=O)O)C5=NC=CC=N5
CHEMBL353330 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
587 10 1 6 4.7 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O
CHEMBL352514 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
541 10 1 5 3.6 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(C6CCC6)C(=O)O
CHEMBL172371 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human CX3C chemokine receptor 5 expressed in CHO cells
561 10 1 6 3.9 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C)(C(C)C)C(=O)O
CHEMBL1951898 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells
659 11 0 11 3.7 CCN(C1CCN(CC1)CCC(C2=CC=CC=C2)N3CCN(CC3)S(=O)(=O)C(F)(F)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL352514 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
541 10 1 5 3.6 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC=CC=C5)C(C6CCC6)C(=O)O
CHEMBL20598 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
541 11 2 7 3.6 CC(CCC1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CC4)C(=O)O)(C5=CC=C(C=C5)F)O
CHEMBL480504 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
514 10 1 6 3.5 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(O5)CC6=CC=CC=C6
CHEMBL480504 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandInhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligand
514 10 1 6 3.5 C1CC1CC(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CN=C(O5)CC6=CC=CC=C6
CHEMBL353330 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
587 10 1 6 4.7 CCN1C(=CC(=N1)CC2=CC=CC=C2)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O
CHEMBL366328 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
633 13 1 7 5.0 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC=C(C=C5)OC(C)(C)C
CHEMBL367461 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
639 11 1 8 3.3 CCN1C(=CC(=N1)CC2=CC=C(C=C2)S(=O)(=O)C)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(=O)O)C(C)(C)C
CHEMBL368182 ccr5_human Human No 8.8 IC50 = 1.6 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
697 11 1 12 5.8 CCC(C)C(C(=O)O)N1CC(C(C1)C2=CC(=CC=C2)F)CN3CCC(CC3)C4=CC(=NN4CC)CC5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F
CHEMBL1172050 ccr5_human Human Yes 8.8 IC50 = 1.6 Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
581 9 2 6 4.2 C=CCN(C1CCN(CC1)CC2CN(CC2(C3=CC=CC=C3)O)C(=O)C4CCCC4)C(=O)NCC5=C(C=C(C=C5)F)F
CHEMBL1172050 ccr5_human Human Yes 8.8 IC50 = 1.6 Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
581 9 2 6 4.2 C=CCN(C1CCN(CC1)CC2CN(CC2(C3=CC=CC=C3)O)C(=O)C4CCCC4)C(=O)NCC5=C(C=C(C=C5)F)F
CHEMBL1172051 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
581 9 2 6 4.2 C=CCN(C1CCN(CC1)CC2CN(CC2(C3=CC=CC=C3)O)C(=O)C4CCCC4)C(=O)NCC5=CC(=C(C=C5)F)F
CHEMBL1172051 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
581 9 2 6 4.2 C=CCN(C1CCN(CC1)CC2CN(CC2(C3=CC=CC=C3)O)C(=O)C4CCCC4)C(=O)NCC5=CC(=C(C=C5)F)F
CHEMBL1288663 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
849 12 2 10 7.6 CC(C)(C)NS(=O)(=O)C1=C(C=C(C(=C1)C(=O)N2CCC(CC2)(CCN3CCC(CC3)N(C4=CC(=CC=C4)F)C(=O)NCC5=CC=C(C=C5)C#N)C6=CC(=CC=C6)F)Cl)F
CHEMBL198150 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed in CHO cells
597 11 0 6 4.5 CCN(C1CCN(CC1)CCC(C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)C)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL198150 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
597 11 0 6 4.5 CCN(C1CCN(CC1)CCC(C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)C)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL3085309 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Displacement of [125I]RANTES from CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from CCR5 expressed in CHO cells
735 17 1 8 6.0 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CC6=CN(N=C6)C
CHEMBL3085307 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Displacement of [125I]RANTES from CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from CCR5 expressed in CHO cells
683 17 1 7 7.0 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CCC
CHEMBL255857 ccr5_human Human No 8.8 IC50 = 1.7 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
534 6 0 6 4.2 CC1=C(C(=[N+](C=C1)[O-])C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(CC4=CSC(=N4)C)C5=CC=CC=C5
CHEMBL437494 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cellsInhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells
567 8 0 5 5.7 CC(=O)N1CCC(CC1)C(=O)N(CCCN2CCC(CC2)SC3=CC=C(C=C3)F)C4=CC(=C(C=C4)Cl)Cl
CHEMBL207630 ccr5_human Human No 8.8 IC50 = 1.7 Funct
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cellsInhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells
592 9 0 6 5.1 CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN2CCC(CC2)CC3=CC=C(C=C3)C#N)C4=CC(=C(C=C4)Cl)Cl
CHEMBL1288663 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Antagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infectionAntagonist activity at CCR5 in human peripheral blood lymphocytes cells assessed as inhibition of HIV-1 Ba-L infection
849 12 2 10 7.6 CC(C)(C)NS(=O)(=O)C1=C(C=C(C(=C1)C(=O)N2CCC(CC2)(CCN3CCC(CC3)N(C4=CC(=CC=C4)F)C(=O)NCC5=CC=C(C=C5)C#N)C6=CC(=CC=C6)F)Cl)F
CHEMBL335562 ccr5_human Human No 8.8 IC50 = 1.7 Funct
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
524 11 1 8 3.1 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CCC4)C(=O)O)C5=CN=CN=C5
CHEMBL198150 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed in CHO cellsDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed in CHO cells
597 11 0 6 4.5 CCN(C1CCN(CC1)CCC(C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)C)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL198150 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Displacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cellsDisplacement of [125I]MIP-1-alpha to human recombinant CCR5 expressed in CHO cells
597 11 0 6 4.5 CCN(C1CCN(CC1)CCC(C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)C)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C
CHEMBL3085309 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Displacement of [125I]RANTES from CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from CCR5 expressed in CHO cells
735 17 1 8 6.0 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CC6=CN(N=C6)C
CHEMBL3085307 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Displacement of [125I]RANTES from CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from CCR5 expressed in CHO cells
683 17 1 7 7.0 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CCC
CHEMBL255857 ccr5_human Human No 8.8 IC50 = 1.7 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
534 6 0 6 4.2 CC1=C(C(=[N+](C=C1)[O-])C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(CC4=CSC(=N4)C)C5=CC=CC=C5
CHEMBL2435906 ccr5_human Human No 8.8 IC50 = 1.7 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
538 8 1 4 5.0 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)C4CCC4)C5=CC=CC=C5)C)Cl
CHEMBL2435847 ccr5_human Human No 8.8 IC50 = 1.7 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
559 5 0 5 4.4 CC1=C(C(=NC=N1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N4C(CN(C4=O)C5CCCCC5)C6=CC=CC=C6
CHEMBL2435862 ccr5_human Human No 8.8 IC50 = 1.7 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
589 9 1 5 4.8 CC1=C(C=NC=C1)CN2CC(N(C2=O)C3CCN(CC3)C(C)CCNC(=O)C4=C(N=C(C=C4C)Cl)C)C5=CC=CC=C5
CHEMBL437494 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cellsInhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells
567 8 0 5 5.7 CC(=O)N1CCC(CC1)C(=O)N(CCCN2CCC(CC2)SC3=CC=C(C=C3)F)C4=CC(=C(C=C4)Cl)Cl
CHEMBL207630 ccr5_human Human No 8.8 IC50 = 1.7 Funct
Inhibition of [125I]RANTES binding to human CCR5 expressed in CHO cellsInhibition of [125I]RANTES binding to human CCR5 expressed in CHO cells
592 9 0 6 5.1 CS(=O)(=O)N1CCC(CC1)C(=O)N(CCCN2CCC(CC2)CC3=CC=C(C=C3)C#N)C4=CC(=C(C=C4)Cl)Cl
CHEMBL366400 ccr5_human Human No 8.8 IC50 = 1.7 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
572 10 1 7 3.4 CCN1C(=CC(=N1)CC2=CC=CC(=C2)C#N)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C(C)C)C(=O)O
CHEMBL368459 ccr5_human Human No 8.8 IC50 = 1.7 Funct
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cellInhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
612 10 1 7 4.5 CCN1C(=CC(=N1)CC2=CC=C(C=C2)C#N)C3CCN(CC3)CC4CN(CC4C5=CC(=CC=C5)F)C(C6CCCCC6)C(=O)O
CHEMBL1172045 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
563 9 2 5 4.1 C=CCN(C1CCN(CC1)CC2CN(CC2(C3=CC=CC=C3)O)C(=O)C4CCCC4)C(=O)NCC5=CC=C(C=C5)F
CHEMBL1172045 ccr5_human Human Yes 8.8 IC50 = 1.7 Funct
Antagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assayAntagonist activity at CCR5 expressed in CHO cells assessed as inhibition of RANTES-induced [35S]GTPgamma binding by scintillation proximity assay
563 9 2 5 4.1 C=CCN(C1CCN(CC1)CC2CN(CC2(C3=CC=CC=C3)O)C(=O)C4CCCC4)C(=O)NCC5=CC=C(C=C5)F
CHEMBL428104 ccr5_human Human No 8.7 IC50 = 1.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
524 11 1 8 3.4 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CCC4)C(=O)O)C5=NC=CC=N5
CHEMBL428104 ccr5_human Human No 8.7 IC50 = 1.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
524 11 1 8 3.4 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CCC4)C(=O)O)C5=NC=CC=N5
CHEMBL255646 ccr5_human Human No 8.7 IC50 = 1.8 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
500 5 0 5 4.1 CC1=C(C(=[N+](C=C1)[O-])C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CC=CC=N5
CHEMBL437494 ccr5_human Human Yes 8.7 IC50 = 1.8 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
567 8 0 5 5.7 CC(=O)N1CCC(CC1)C(=O)N(CCCN2CCC(CC2)SC3=CC=C(C=C3)F)C4=CC(=C(C=C4)Cl)Cl
CHEMBL2435859 ccr5_human Human No 8.8 IC50 = 1.8 Funct
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated for 15 mins by spectrophotometric analysis
580 9 1 4 6.4 CC1=CC(=NC(=C1C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)CC4CCCCC4)C5=CC=CC=C5)C)Cl
CHEMBL428104 ccr5_human Human No 8.8 IC50 = 1.8 Funct
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
524 11 1 8 3.4 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CCC4)C(=O)O)C5=NC=CC=N5
CHEMBL428104 ccr5_human Human No 8.8 IC50 = 1.8 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
524 11 1 8 3.4 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC(=CC=C3)F)C(CC4CCC4)C(=O)O)C5=NC=CC=N5
CHEMBL255646 ccr5_human Human No 8.8 IC50 = 1.8 Funct
Displacement of [125I]RANTES from human CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from human CCR5 expressed in CHO cells
500 5 0 5 4.1 CC1=C(C(=[N+](C=C1)[O-])C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(C4=CC=CC=C4)C5=CC=CC=N5
CHEMBL437494 ccr5_human Human Yes 8.8 IC50 = 1.8 Funct
Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5Inhibition of membrane fusion between HIV1 JR-FL Env-expressing COS7 cells and MOLT4/CCR5
567 8 0 5 5.7 CC(=O)N1CCC(CC1)C(=O)N(CCCN2CCC(CC2)SC3=CC=C(C=C3)F)C4=CC(=C(C=C4)Cl)Cl
CHEMBL204821 ccr5_human Human No 8.7 IC50 = 1.9 Funct
Displacement of [125I]RANTES from CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from CCR5 expressed in CHO cells
683 17 1 7 7.1 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CC(C)C
CHEMBL204821 ccr5_human Human No 8.7 IC50 = 1.9 Funct
Displacement of [125I]RANTES from CCR5 expressed in CHO cellsDisplacement of [125I]RANTES from CCR5 expressed in CHO cells
683 17 1 7 7.1 CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CC(C)C
CHEMBL82168 ccr5_human Human No 8.7 IC50 = 2.0 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
576 14 0 6 5.8 CN(CC(CCN1CCC(CC1)N(CC=C)C(=O)OCC2=CC=CC=C2)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4
CHEMBL2282503 ccr5_human Human No 8.7 IC50 = 2.0 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
591 12 0 7 5.4 CN(CC(CCN1CCC(CC1)N(CC=C)C(=O)C2=CC=C(C=C2)[N+](=O)[O-])C3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4
CHEMBL83335 ccr5_human Human Yes 8.7 IC50 = 2.0 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
621 14 0 8 5.6 CN(CC(CCN1CCC(CC1)N(CC=C)C(=O)OCC2=CC=C(C=C2)[N+](=O)[O-])C3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4
CHEMBL85086 ccr5_human Human No 8.7 IC50 = 2.0 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
564 13 0 6 5.5 CCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)OCC4=CC=CC=C4
CHEMBL592940 ccr5_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
552 6 0 7 3.8 CC1=C(C(=NC=N1)C)C(=O)N2CC3CN(CC3C2)CCC4(CN(C4)C(=O)C5CCC(CC5)(F)F)C6=CC=CC=C6
CHEMBL1784400 ccr5_human Human No 8.0 IC50 = 10 Funct
Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation countingDisplacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation counting
551 6 0 4 6.8 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C6=CC=CC=C6)C7=CC=CC=C7)C=CC(=C2)F
CHEMBL445925 ccr5_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
500 7 2 4 4.2 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CNC6=CC=CC=C65
CHEMBL138645 ccr5_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
461 8 0 4 5.1 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC=CC=C3)C(=O)C4CCC4)C5=CC=CC=N5
CHEMBL319689 ccr5_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
519 10 2 5 4.1 C1CCC(CC1)CN2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=C(C=C5)C(=O)O)O
CHEMBL1078335 ccr5_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cellsDisplacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cells
555 7 0 6 4.9 CCCCC1CN(C(=O)OC12CCN(CC2)C3(CCN(CC3)C(=O)C4=C(C=CN=C4C)C)C)CC5CCCCO5
CHEMBL1077779 ccr5_human Human Yes 8.0 IC50 = 10 Funct
Displacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cellsDisplacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cells
538 7 0 4 7.2 CCCCC1C2(CCN(CC2)C3(CCN(CC3)C(=O)C4=C(C=CC=C4C)C)C)OC(=O)N1CC5CCCCC5
CHEMBL1762463 ccr5_human Human Yes 8.0 IC50 = 10 Funct
Displacement of [128I]-RANTES from CCR5 expressed in HEK293F cellsDisplacement of [128I]-RANTES from CCR5 expressed in HEK293F cells
626 10 1 7 5.6 CC(CCNC(=O)C1=C(C=NC=C1Cl)Cl)N2CCC(CC2)C(C3=CC=C(C=C3)S(=O)(=O)C)OC4=NC(=CC=C4)Cl
CHEMBL83338 ccr5_human Human No 8.0 IC50 = 10 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
557 8 0 6 4.9 CN(CC(CCN1CCC2(CC1)CS(=O)C3=CC=CC=C23)C4=CC(=CC=C4)Cl)S(=O)(=O)C5=CC=CC=C5
CHEMBL3577948 ccr5_human Human No 8.0 IC50 = 10 Funct
Inhibition of [125I]MCP1-beta binding to CCR5 in human HT1080 cell membranes incubated for 4 to 6 hrsInhibition of [125I]MCP1-beta binding to CCR5 in human HT1080 cell membranes incubated for 4 to 6 hrs
492 6 1 8 5.8 CC(C)C1CC(CCC1N2CCC(C2=O)NC3=NC=NC4=C3C=C(C=C4)C(F)(F)F)N(C)C(C)C
CHEMBL311532 ccr5_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
550 12 0 6 5.6 CCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)OC4=CC=CC=C4
CHEMBL79667 ccr5_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
544 15 0 6 6.0 CCCCCCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)OC
CHEMBL592940 ccr5_human Human No 8.0 IC50 = 10 Funct
Antagonist activity at human recombinant CCR5 by cell-cell fusion assayAntagonist activity at human recombinant CCR5 by cell-cell fusion assay
552 6 0 7 3.8 CC1=C(C(=NC=N1)C)C(=O)N2CC3CN(CC3C2)CCC4(CN(C4)C(=O)C5CCC(CC5)(F)F)C6=CC=CC=C6
CHEMBL105570 ccr5_human Human No 8.0 IC50 = 10 Funct
Binding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligandBinding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligand
582 12 0 6 6.5 CC(CCN1CCC(CC1)N(CC=C)C(=O)OCC2=CC=C(C=C2)[N+](=O)[O-])(CN3C=NC4=CC=CC=C43)C5=CC=CC=C5
CHEMBL83338 ccr5_human Human No 8.0 IC50 = 10 Funct
Binding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligandBinding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligand
557 8 0 6 4.9 CN(CC(CCN1CCC2(CC1)CS(=O)C3=CC=CC=C23)C4=CC(=CC=C4)Cl)S(=O)(=O)C5=CC=CC=C5
CHEMBL138645 ccr5_human Human No 8.0 IC50 = 10 Funct
Displacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranesDisplacement inhibition of 125-I labeled MIP-alpha from CCR5 receptor expressed on CHO cell membranes
461 8 0 4 5.1 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC=CC=C3)C(=O)C4CCC4)C5=CC=CC=N5
CHEMBL1784400 ccr5_human Human No 8.0 IC50 = 10 Funct
Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation countingDisplacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation counting
551 6 0 4 6.8 CC1=NC2=C(N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C6=CC=CC=C6)C7=CC=CC=C7)C=CC(=C2)F
CHEMBL445925 ccr5_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
500 7 2 4 4.2 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)C5=CNC6=CC=CC=C65
CHEMBL319689 ccr5_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
519 10 2 5 4.1 C1CCC(CC1)CN2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=C(C=C5)C(=O)O)O
CHEMBL138645 ccr5_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
461 8 0 4 5.1 CCCN(C1CCN(CC1)CC2CN(CC2C3=CC=CC=C3)C(=O)C4CCC4)C5=CC=CC=N5
CHEMBL319689 ccr5_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
519 10 2 5 4.1 C1CCC(CC1)CN2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=C(C=C5)C(=O)O)O
CHEMBL1078335 ccr5_human Human No 8.0 IC50 = 10 Funct
Displacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cellsDisplacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cells
555 7 0 6 4.9 CCCCC1CN(C(=O)OC12CCN(CC2)C3(CCN(CC3)C(=O)C4=C(C=CN=C4C)C)C)CC5CCCCO5
CHEMBL1077779 ccr5_human Human Yes 8.0 IC50 = 10 Funct
Displacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cellsDisplacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cells
538 7 0 4 7.2 CCCCC1C2(CCN(CC2)C3(CCN(CC3)C(=O)C4=C(C=CC=C4C)C)C)OC(=O)N1CC5CCCCC5
CHEMBL1762463 ccr5_human Human Yes 8.0 IC50 = 10 Funct
Displacement of [128I]-RANTES from CCR5 expressed in HEK293F cellsDisplacement of [128I]-RANTES from CCR5 expressed in HEK293F cells
626 10 1 7 5.6 CC(CCNC(=O)C1=C(C=NC=C1Cl)Cl)N2CCC(CC2)C(C3=CC=C(C=C3)S(=O)(=O)C)OC4=NC(=CC=C4)Cl
CHEMBL311532 ccr5_human Human No 8.0 IC50 = 10 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
550 12 0 6 5.6 CCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)OC4=CC=CC=C4
CHEMBL83338 ccr5_human Human No 8.0 IC50 = 10 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
557 8 0 6 4.9 CN(CC(CCN1CCC2(CC1)CS(=O)C3=CC=CC=C23)C4=CC(=CC=C4)Cl)S(=O)(=O)C5=CC=CC=C5
CHEMBL79667 ccr5_human Human No 8.0 IC50 = 10 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
544 15 0 6 6.0 CCCCCCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)OC
CHEMBL3577948 ccr5_human Human No 8.0 IC50 = 10 Funct
Inhibition of [125I]MCP1-beta binding to CCR5 in human HT1080 cell membranes incubated for 4 to 6 hrsInhibition of [125I]MCP1-beta binding to CCR5 in human HT1080 cell membranes incubated for 4 to 6 hrs
492 6 1 8 5.8 CC(C)C1CC(CCC1N2CCC(C2=O)NC3=NC=NC4=C3C=C(C=C4)C(F)(F)F)N(C)C(C)C
CHEMBL83338 ccr5_human Human No 8.0 IC50 = 10 Funct
Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.Inhibitory activity against specific binding of [125I]-MIP-1 alpha to human CCR5 receptor.
557 8 0 6 4.9 CN(CC(CCN1CCC2(CC1)CS(=O)C3=CC=CC=C23)C4=CC(=CC=C4)Cl)S(=O)(=O)C5=CC=CC=C5
CHEMBL361585 ccr5_human Human No 8.0 IC50 = 10 Funct
Inhibitory concentration against human C-C chemokine receptor type 5 in CHO cells with [125I]-MIP-1 alpha radioligandInhibitory concentration against human C-C chemokine receptor type 5 in CHO cells with [125I]-MIP-1 alpha radioligand
560 10 0 5 5.3 CC(CCN1CCC2C(C1)CCC(=O)N2CC3=CC=CC=C3)(CN(C)S(=O)(=O)C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL2435891 ccr5_human Human No 8.0 IC50 = 10.4 Funct
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assayInhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV-1 Tat and human HeLa cells expressing CD4 after 20 hrs by beta-galactosidase reporter gene assay
612 8 1 5 5.0 CC1=C(C(=NC=N1)C)C(=O)NCCC(C)N2CCC(CC2)N3C(CN(C3=O)C4CCCCC4)C5=CC(=CC=C5)Br
CHEMBL59511 ccr5_human Human No 8.0 IC50 = 10.8 Funct
Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.
538 6 0 5 4.4 CC1=C(C(=[N+](C=C1)[O-])C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)N(CC4=CC=CC(=C4)C#N)C5=CC=CC=C5
CHEMBL3397991 ccr5_human Human No 8.0 IC50 = 10.9 Funct
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
593 8 0 7 3.8 CC1CN(CCN1CCCN(C2=CC(=C(C=C2)C)Cl)C(=O)C3CCN(CC3)C(=O)C)S(=O)(=O)C4=CC=C(C=C4)F
CHEMBL1926888 ccr5_human Human No 8.0 IC50 = 10.9 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
517 10 1 7 4.2 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(N=CN=C3C)C)C4=CC=C(C=C4)OC
CHEMBL3397991 ccr5_human Human No 8.0 IC50 = 10.9 Funct
Antagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilizationAntagonist activity against CCR5 (unknown origin) expressed in CHO cells co-expressing Galpha16 incubated for 10 mins assessed as inhibition of RANTES-induced calcium mobilization
593 8 0 7 3.8 CC1CN(CCN1CCCN(C2=CC(=C(C=C2)C)Cl)C(=O)C3CCN(CC3)C(=O)C)S(=O)(=O)C4=CC=C(C=C4)F
CHEMBL1926888 ccr5_human Human No 8.0 IC50 = 10.9 Funct
Antagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assayAntagonist activity against human CCR5 assessed as inhibition of HIV1 gp120-induced cell-cell fusion between human HeLa P4/R5 cells and CHO-tat10 cells expressing HIV-1JRFL viral envolop protein after 20 hrs by beta-galactosidase reporter gene assay
517 10 1 7 4.2 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(N=CN=C3C)C)C4=CC=C(C=C4)OC
CHEMBL1926888 ccr5_human Human No 8.0 IC50 = 10.9 Funct
Antagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assayAntagonist activity at CCR5 receptor expressed in P4R5 cells co-expressing CD4, and LTR-beta-gal construct assessed as inhibition of infusion to HIV gp120 expressed in CHO-tat cells expressing HIV-1 JRFLenv and HIV-1 Tat by beta-galactosidase activity based cell-cell fusion assay
517 10 1 7 4.2 CC1=C(C=NC=C1)CN(C2CCN(CC2)C(C)CCNC(=O)C3=C(N=CN=C3C)C)C4=CC=C(C=C4)OC
CHEMBL2281968 ccr5_human Human No 8.0 IC50 = 11.0 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
614 10 3 3 7.9 CCC1=C(C(=CC=C1)CC)NC(=O)NCC2(CCC(CC2)CC3=C(C=CC(=C3)Br)OCC4=CC=C(C=C4)Cl)O
CHEMBL1784398 ccr5_human Human No 7.0 IC50 = 100 Funct
Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation countingDisplacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation counting
587 6 0 6 7.2 C1CC2CC(CC1N2CCC3(CCN(CC3)C(=O)C4=CC=CC=C4)C5=CC=CC=C5)N6C7=CC=CC=C7N=C6C(F)(F)F
CHEMBL192456 ccr5_human Human No 7.0 IC50 = 100 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
529 7 1 5 3.0 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)N5C=NC(=O)C6=CC=CC=C65
CHEMBL103268 ccr5_human Human No 7.0 IC50 = 100 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
519 10 2 5 4.1 C1CCC(CC1)CN2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=CC=C5C(=O)O)O
CHEMBL234208 ccr5_human Human Yes 7.0 IC50 = 100 Funct
Displacement of [125I]MIP1alpha from human CCR5 receptor expressed in HEK293 cells co-expressing CD4Displacement of [125I]MIP1alpha from human CCR5 receptor expressed in HEK293 cells co-expressing CD4
601 8 3 4 6.0 CC1=CC(=C(C(=C1)C)NC(=O)NCC2(CCN(CC2)CC3=C(C=CC(=C3)Br)OCC4=CC=C(C=C4)Cl)O)C
CHEMBL271076 ccr5_human Human Yes 7.0 IC50 = 100 Funct
Displacement of [125I]MIP1beta from human recombinant CCR5 receptor expressed in CHOK1 cellsDisplacement of [125I]MIP1beta from human recombinant CCR5 receptor expressed in CHOK1 cells
521 8 1 4 5.5 CC1=NN=C(N1C2CC3CCC(C2)N3CCCN(C4=CC=CC=C4)C(=O)NC5=CC=CC=C5Cl)C(C)C
CHEMBL1078141 ccr5_human Human No 7.0 IC50 = 100 Funct
Displacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cellsDisplacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cells
556 7 0 7 4.1 CCCCC1CN(C(=O)OC12CCN(CC2)C3(CCN(CC3)C(=O)C4=C(N=CN=C4C)C)C)CC5CCOCC5
CHEMBL1077988 ccr5_human Human Yes 7.0 IC50 = 100 Funct
Displacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cellsDisplacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cells
510 7 0 4 6.6 CCCCC1C2(CCN(CC2)C3CCN(CC3)C(=O)C4=CC=CC=C4C)OC(=O)N1CC5CCCCC5
CHEMBL1762317 ccr5_human Human Yes 7.0 IC50 = 100 Funct
Displacement of [128I]-RANTES from CCR5 expressed in HEK293F cellsDisplacement of [128I]-RANTES from CCR5 expressed in HEK293F cells
605 9 1 8 6.8 CC(CCNC(=O)C1=C(C=NC=C1Cl)Cl)N2CCC(CC2)C(C3=CC=C(C=C3)C(F)(F)F)OC4=CC=CC=C4C#N
CHEMBL88159 ccr5_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
606 9 0 6 5.5 CN(CC(CCN1CCC2(CC1)CS(=O)C3=CC=CC=C23)C4=CC(=C(C=C4)Cl)Cl)S(=O)(=O)CC5=CC=CC=C5
CHEMBL2282507 ccr5_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
563 12 1 5 5.0 CCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)NCC4=CC=CC=C4
CHEMBL2281966 ccr5_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
600 8 3 3 7.4 CC1=CC(=C(C(=C1)C)NC(=O)NCC2(CCC(CC2)CC3=C(C=CC(=C3)Br)OCC4=CC=C(C=C4)Cl)O)C
CHEMBL2282504 ccr5_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
548 12 0 5 5.8 CCCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)C4=CC=CC=C4
CHEMBL79315 ccr5_human Human No 7.0 IC50 = 100 Funct
Antagonist activity at Homo sapiens (human) CCR5 receptorAntagonist activity at Homo sapiens (human) CCR5 receptor
550 12 0 6 5.2 CN(CC(CCN1CCC(CC1)N(CC2=CC=CC=C2)C(=O)OC)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4
CHEMBL61465 ccr5_human Human No 7.0 IC50 = 100 Funct
Antagonistic activity against human C-C chemokine receptor type 5.Antagonistic activity against human C-C chemokine receptor type 5.
406 4 1 3 5.1 CC1=C(C(=CC=C1)C)C(=O)N2CCC(CC2)(C)N3CCC(CC3)NC4=CC=CC=C4
CHEMBL107749 ccr5_human Human Yes 7.0 IC50 = 100 Funct
Binding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligandBinding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligand
569 9 2 3 6.8 CC(CCN1CCC(CC1)C2=CC=CC=C2)(CN3C(=O)C(NC3=O)CC4=CNC5=CC=CC=C54)C6=CC(=CC=C6)Cl
CHEMBL87167 ccr5_human Human No 7.0 IC50 = 100 Funct
Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandBinding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand
584 8 0 6 5.3 CN(CC(CCN1CCC2(CC1)CS(=O)C3=CC=CC=C23)C4=CC(=C(C=C4)Cl)Cl)S(=O)(=O)C5CCCC5
CHEMBL421356 ccr5_human Human No 7.0 IC50 = 100 Funct
Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandBinding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand
608 8 0 6 5.7 CN(CC(CCN1CCC2(CC1)CS(=O)(=O)C3=CC=CC=C23)C4=CC(=C(C=C4)Cl)Cl)S(=O)(=O)C5=CC=CC=C5
CHEMBL89167 ccr5_human Human No 7.0 IC50 = 100 Funct
Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandBinding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand
593 8 0 7 4.5 CN(CC(CCN1CCC2(CC1)CS(=O)C3=CC=CC=C23)C4=CC(=C(C=C4)Cl)Cl)S(=O)(=O)C5=CN=CC=C5
CHEMBL88644 ccr5_human Human No 7.0 IC50 = 100 Funct
Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandBinding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand
598 8 0 6 5.8 CN(CC(CCN1CCC2(CC1)CS(=O)C3=CC=CC=C23)C4=CC(=C(C=C4)Cl)Cl)S(=O)(=O)C5CCCCC5
CHEMBL183406 ccr5_human Human No 7.0 IC50 = 100 Funct
Binding of [125I]RANTES to membranes prepared from chinese hamster ovary (CHO) cells stably expressing recombinant human C-C chemokine receptor type 5Binding of [125I]RANTES to membranes prepared from chinese hamster ovary (CHO) cells stably expressing recombinant human C-C chemokine receptor type 5
442 8 1 2 5.4 CN(C1CCN(CC1)CCC(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)NCC4=CC=CC=C4
CHEMBL1784398 ccr5_human Human No 7.0 IC50 = 100 Funct
Displacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation countingDisplacement of 125I-MIP-1beta from human CCR5 receptor after 4 hrs by scintillation counting
587 6 0 6 7.2 C1CC2CC(CC1N2CCC3(CCN(CC3)C(=O)C4=CC=CC=C4)C5=CC=CC=C5)N6C7=CC=CC=C7N=C6C(F)(F)F
CHEMBL192456 ccr5_human Human No 7.0 IC50 = 100 Funct
Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranes
529 7 1 5 3.0 C1CCC(CC1)C(C(=O)O)N2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)N5C=NC(=O)C6=CC=CC=C65
CHEMBL103268 ccr5_human Human No 7.0 IC50 = 100 Funct
Displacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesDisplacement of [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes
519 10 2 5 4.1 C1CCC(CC1)CN2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=CC=C5C(=O)O)O
CHEMBL103268 ccr5_human Human No 7.0 IC50 = 100 Funct
Displacement of [125I]MIP1alpha from human CCR5 expressed in CHO cellsDisplacement of [125I]MIP1alpha from human CCR5 expressed in CHO cells
519 10 2 5 4.1 C1CCC(CC1)CN2CC(C(C2)C3=CC=CC=C3)CN4CCC(CC4)(CCCC5=CC=CC=C5C(=O)O)O
CHEMBL234208 ccr5_human Human Yes 7.0 IC50 = 100 Funct
Displacement of [125I]MIP1alpha from human CCR5 receptor expressed in HEK293 cells co-expressing CD4Displacement of [125I]MIP1alpha from human CCR5 receptor expressed in HEK293 cells co-expressing CD4
601 8 3 4 6.0 CC1=CC(=C(C(=C1)C)NC(=O)NCC2(CCN(CC2)CC3=C(C=CC(=C3)Br)OCC4=CC=C(C=C4)Cl)O)C
CHEMBL271076 ccr5_human Human Yes 7.0 IC50 = 100 Funct
Displacement of [125I]MIP1beta from human recombinant CCR5 receptor expressed in CHOK1 cellsDisplacement of [125I]MIP1beta from human recombinant CCR5 receptor expressed in CHOK1 cells
521 8 1 4 5.5 CC1=NN=C(N1C2CC3CCC(C2)N3CCCN(C4=CC=CC=C4)C(=O)NC5=CC=CC=C5Cl)C(C)C
CHEMBL1078141 ccr5_human Human No 7.0 IC50 = 100 Funct
Displacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cellsDisplacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cells
556 7 0 7 4.1 CCCCC1CN(C(=O)OC12CCN(CC2)C3(CCN(CC3)C(=O)C4=C(N=CN=C4C)C)C)CC5CCOCC5
CHEMBL1077988 ccr5_human Human Yes 7.0 IC50 = 100 Funct
Displacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cellsDisplacement of [125I]RANTES from human CCR5 receptor co-transfected with Galphai6 in CHO cells
510 7 0 4 6.6 CCCCC1C2(CCN(CC2)C3CCN(CC3)C(=O)C4=CC=CC=C4C)OC(=O)N1CC5CCCCC5
CHEMBL1762317 ccr5_human Human Yes 7.0 IC50 = 100 Funct
Displacement of [128I]-RANTES from CCR5 expressed in HEK293F cellsDisplacement of [128I]-RANTES from CCR5 expressed in HEK293F cells
605 9 1 8 6.8 CC(CCNC(=O)C1=C(C=NC=C1Cl)Cl)N2CCC(CC2)C(C3=CC=C(C=C3)C(F)(F)F)OC4=CC=CC=C4C#N
CHEMBL309922 ccr5_human Human No 7.0 IC50 = 100 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
535 11 2 5 4.4 CN(CC(CCN1CCC(CC1)NC(=O)NCC2=CC=CC=C2)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4
CHEMBL82879 ccr5_human Human No 7.0 IC50 = 100 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
548 12 0 5 5.8 CCCN(C1CCN(CC1)CCC(CN(C)S(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)C4=CC=CC=C4
CHEMBL83745 ccr5_human Human No 7.0 IC50 = 100 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
552 8 0 5 4.9 CN1C(=O)C2=CC=CC=C2C13CCN(CC3)CCC(CN(C)S(=O)(=O)C4=CC=CC=C4)C5=CC(=CC=C5)Cl
CHEMBL79566 ccr5_human Human No 7.0 IC50 = 100 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
539 8 1 5 5.4 CN(CC(CCN1CCC2(CC1)CC(C3=CC=CC=C23)O)C4=CC(=CC=C4)Cl)S(=O)(=O)C5=CC=CC=C5
CHEMBL79315 ccr5_human Human No 7.0 IC50 = 100 Funct
Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsInhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cells
550 12 0 6 5.2