GPCRdb

Variation Browser

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Receptor	Position	GPCRdb	Segment	Variant	Mutation type	Allele Frequency	Allele Count	Allele Number	Homozygotes	SIFT score	PolyPhen score	Functional annotation


Receptor	Position	GPCRdb	Segment	Variant	Mutation Type	Allele Frequency	Allele Count	Allele Number	Homozygotes	SIFT score	PolyPhen score	Functional annotation
acm2_human	55	12.51x51	ICL1	Q => Ter	stop gained	8.252e-06	1	121188	0	None	None
acm2_human	288		ICL3	S => Ter	stop gained	8.281e-06	1	120760	0	None	None	PTM (Phosphorylation)
acm2_human	375		ICL3	K => Ter	stop gained	8.256e-06	1	121130	0	None	None
acm2_human	403	6.51x51	TM6	Y => Ter	stop gained	8.26e-06	1	121060	0	None	None	LB (hydrophobic, polar (hydrogen bond))
acm2_human	3		N-term	N => S	missense	8.294e-06	1	120566	0	0.43	0.0	PTM (N-linked Glycosylation)
acm2_human	6		N-term	N => K	missense	1.657e-05	2	120668	0	0.18	0.0	PTM (N-linked Glycosylation)
acm2_human	9		N-term	N => D	missense	8.285e-06	1	120696	0	0.39	0.0
acm2_human	11		N-term	S => C	missense	8.283e-06	1	120736	0	0.02	0.0
acm2_human	13		N-term	A => D	missense	1.656e-05	2	120774	0	0.62	0.0
acm2_human	15		N-term	T => S	missense	8.279e-06	1	120794	0	0.73	0.0
acm2_human	16		N-term	S => N	missense	8.278e-06	1	120808	0	0.09	0.0
acm2_human	17		N-term	P => L	missense	8.277e-06	1	120824	0	0.02	1.0
acm2_human	19	1.28x28	TM1	K => E	missense	8.275e-06	1	120846	0	0.47	0.009
acm2_human	20	1.29x29	TM1	T => I	missense	8.274e-06	1	120860	0	0.44	0.548
acm2_human	25	1.34x34	TM1	F => L	missense	8.271e-06	1	120910	0	1.0	0.016
acm2_human	31	1.40x40	TM1	G => A	missense	8.267e-06	1	120960	0	0.34	0.082
acm2_human	36	1.45x45	TM1	V => L	missense	8.265e-06	1	120998	0	0.04	0.085
acm2_human	38	1.47x47	TM1	I => T	missense	8.263e-06	1	121020	0	0.01	0.005
acm2_human	52	12.48x48	ICL1	R => H	missense	1.651e-05	2	121158	0	0.01	0.998
acm2_human	57	2.38x38	TM2	V => I	missense	7.427e-05	9	121176	0	0.03	0.927
acm2_human	78	2.59x58	TM2	N => K	missense	8.244e-06	1	121300	0	0.0	1.0
acm2_human	79	2.60x59	TM2	L => F	missense	8.245e-06	1	121290	0	0.01	0.942
acm2_human	80	2.61x60	TM2	Y => F	missense	8.244e-06	1	121300	0	0.1	0.999	LB (polar (hydrogen bond))
acm2_human	86	2.67x66	TM2	I => T	missense	8.243e-06	1	121314	0	0.06	0.159
acm2_human	133	34.55x55	ICL2	V => L	missense	8.257e-06	1	121112	0	0.01	0.643	GP (contact)
acm2_human	142	4.44x44	TM4	M => I	missense	8.273e-06	1	120870	0	0.92	0.01
acm2_human	154	4.56x56	TM4	L => V	missense	8.286e-06	1	120684	0	0.0	0.999
acm2_human	158	4.60x60	TM4	A => D	missense	8.282e-06	1	120742	0	0.0	1.0
acm2_human	172		ECL2	E => D	missense	1.654e-05	2	120902	0	0.04	0.09
acm2_human	174		ECL2	G => E	missense	8.269e-06	1	120932	0	0.32	0.236
acm2_human	197	5.49x49	TM5	L => F	missense	8.275e-06	1	120846	0	0.01	0.998
acm2_human	199	5.51x51	TM5	V => M	missense	8.276e-06	1	120830	0	0.0	0.996
acm2_human	210	5.62x62	TM5	S => T	missense	8.303e-06	1	120432	0	0.02	0.934
acm2_human	211	5.63x63	TM5	R => Q	missense	1.662e-05	2	120328	0	0.23	0.015
acm2_human	211	5.63x63	TM5	R => L	missense	8.311e-06	1	120328	0	0.29	0.007
acm2_human	225		ICL3	V => D	missense	8.35e-05	10	119764	0	0.51	0.016
acm2_human	227		ICL3	N => S	missense	8.352e-06	1	119736	0	0.69	0.004
acm2_human	227		ICL3	N => K	missense	8.353e-06	1	119714	0	0.84	0.009
acm2_human	229		ICL3	D => G	missense	1.671e-05	2	119694	0	0.45	0.004
acm2_human	230		ICL3	P => S	missense	8.355e-06	1	119690	0	0.88	0.014
acm2_human	231		ICL3	V => I	missense	0.002983	357	119660	1	0.21	0.009
acm2_human	235		ICL3	L => M	missense	0.0002924	35	119718	0	0.28	0.726
acm2_human	238		ICL3	G => A	missense	6.677e-05	8	119810	0	0.35	0.023
acm2_human	240		ICL3	I => R	missense	1.669e-05	2	119844	0	0.4	0.024
acm2_human	241		ICL3	V => M	missense	8.346e-06	1	119822	0	0.14	0.026
acm2_human	242		ICL3	K => R	missense	1.669e-05	2	119862	0	0.3	0.05
acm2_human	243		ICL3	P => S	missense	8.344e-06	1	119848	0	0.42	0.004
acm2_human	246		ICL3	N => D	missense	1.668e-05	2	119932	0	0.49	0.188
acm2_human	246		ICL3	N => K	missense	3.335e-05	4	119926	0	0.66	0.135
acm2_human	253		ICL3	D => N	missense	0.000125	15	119998	0	0.45	0.146
acm2_human	254		ICL3	G => V	missense	1.666e-05	2	120072	0	0.24	0.014
acm2_human	255		ICL3	L => V	missense	8.328e-06	1	120076	0	0.34	0.014
acm2_human	258		ICL3	N => S	missense	0.001449	174	120100	0	0.74	0.004
acm2_human	258		ICL3	N => K	missense	8.328e-06	1	120084	0	0.62	0.009
acm2_human	262		ICL3	N => S	missense	8.324e-06	1	120140	0	0.95	0.377
acm2_human	274		ICL3	C => R	missense	8.309e-06	1	120356	0	0.17	0.02
acm2_human	274		ICL3	C => S	missense	8.309e-06	1	120354	0	0.48	0.216
acm2_human	275		ICL3	V => A	missense	8.308e-06	1	120372	0	0.59	0.005
acm2_human	277		ICL3	G => E	missense	1.66e-05	2	120464	0	0.44	0.691
acm2_human	287		ICL3	T => S	missense	0.000174	21	120718	0	1.0	0.015	PTM (Phosphorylation)
acm2_human	292		ICL3	V => A	missense	8.277e-06	1	120814	0	0.74	0.002
acm2_human	296		ICL3	M => T	missense	8.275e-06	1	120840	0	0.59	0.002
acm2_human	303		ICL3	Q => P	missense	8.271e-06	1	120910	0	0.27	0.002
acm2_human	304		ICL3	D => V	missense	8.27e-06	1	120914	0	0.17	0.004
acm2_human	311		ICL3	S => Y	missense	8.263e-06	1	121024	0	0.04	0.903	PTM (Phosphorylation)
acm2_human	312		ICL3	L => Q	missense	8.262e-06	1	121034	0	0.62	0.004
acm2_human	312		ICL3	L => P	missense	8.262e-06	1	121034	0	0.3	0.18
acm2_human	321		ICL3	K => T	missense	8.258e-06	1	121102	0	0.2	0.201
acm2_human	325		ICL3	I => F	missense	2.477e-05	3	121138	0	0.54	0.03
acm2_human	326		ICL3	R => K	missense	1.651e-05	2	121126	0	1.0	0.004
acm2_human	329		ICL3	T => S	missense	8.256e-06	1	121130	0	0.7	0.402
acm2_human	331		ICL3	T => S	missense	0.001651	200	121132	3	0.85	0.004
acm2_human	337		ICL3	C => Y	missense	8.257e-06	1	121114	0	0.65	0.004
acm2_human	343		ICL3	T => I	missense	8.26e-06	1	121072	0	0.2	0.148
acm2_human	344		ICL3	V => M	missense	2.478e-05	3	121084	0	0.23	0.327
acm2_human	344		ICL3	V => G	missense	5.78e-05	7	121098	0	0.37	0.493
acm2_human	344		ICL3	V => A	missense	8.258e-06	1	121098	0	0.58	0.02
acm2_human	348		ICL3	G => R	missense	8.259e-06	1	121086	0	0.51	0.756
acm2_human	352		ICL3	Q => K	missense	8.258e-06	1	121088	0	1.0	0.027
acm2_human	358		ICL3	Q => H	missense	8.257e-06	1	121104	0	0.18	0.91
acm2_human	363		ICL3	R => C	missense	8.258e-06	1	121088	0	0.15	0.12
acm2_human	363		ICL3	R => H	missense	3.304e-05	4	121070	0	0.06	0.911
acm2_human	368		ICL3	M => T	missense	8.257e-06	1	121116	0	0.45	0.216
acm2_human	372		ICL3	P => A	missense	0.001263	153	121108	0	0.75	0.036
acm2_human	372		ICL3	P => H	missense	8.257e-06	1	121106	0	0.13	0.873
acm2_human	373		ICL3	A => T	missense	8.257e-06	1	121110	0	0.6	0.266
acm2_human	378	6.26x26	TM6	P => L	missense	8.255e-06	1	121132	0	0.32	0.063	GP (contact)
acm2_human	379	6.27x27	TM6	P => A	missense	8.256e-06	1	121128	0	0.83	0.004
acm2_human	390	6.38x38	TM6	L => S	missense	8.257e-06	1	121106	0	0.11	0.836
acm2_human	397	6.45x45	TM6	I => V	missense	3.303e-05	4	121096	0	0.19	0.107
acm2_human	410	6.58x58	TM6	N => S	missense	8.264e-06	1	121012	0	0.97	0.145	LB (polar (hydrogen bond))
acm2_human	411	6.59x59	TM6	T => N	missense	8.264e-06	1	121008	0	0.0	0.756
acm2_human	420	7.33x32	TM7	T => S	missense	8.259e-06	1	121086	0	0.48	0.223
acm2_human	456	8.59x59	H8	M => T	missense	8.267e-06	1	120966	0	0.03	0.007
acm2_human	456	8.59x59	H8	M => R	missense	8.267e-06	1	120966	0	0.04	0.003
acm2_human	462		C-term	I => T	missense	8.282e-06	1	120746	0	0.1	0.703
acm2_human	463		C-term	G => S	missense	8.291e-06	1	120610	0	0.18	0.77
acm2_human	464		C-term	A => T	missense	1.659e-05	2	120584	0	1.0	0.002

Residue

deleterious missense variants are shown in red
tolerated missense variants are shown in green
loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue

Diagrams

SnakePlot Download: PNG | SVG
HelixBox Download: PNG | SVG

Package	Name	Version
Django		2.2.1
Python		3.6.7
debug_toolbar	Debug Toolbar	1.11
polymorphic	Polymorphic	2.0.3
rest_framework	Django REST framework	3.9.3
rest_framework_swagger	Rest_Framework_Swagger	2.2.0

Resource	Value
User CPU time	4928.372 msec
System CPU time	225.425 msec
Total CPU time	5153.797 msec
Elapsed time	5549.898 msec
Context switches	482 voluntary, 26 involuntary

Setting	Value
ABSOLUTE_URL_OVERRIDES	`{}`
ADMINS	`[]`
ALLOWED_HOSTS	`['*']`
APPEND_SLASH	`True`
AUTHENTICATION_BACKENDS	`['django.contrib.auth.backends.ModelBackend']`
AUTH_PASSWORD_VALIDATORS	`'********************'`
AUTH_USER_MODEL	`'auth.User'`
BASE_DIR	`'/home/protwis/gpcrdb_test'`
BUILD_CACHE_DIR	`'/home/protwis/gpcrdb_data/cache'`
CACHES	`{'alignments': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test_alignment', 'OPTIONS': {'MAX_ENTRIES': 1000}}, 'default': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test/', 'OPTIONS': {'MAX_ENTRIES': 10000000}}}`
CACHE_MIDDLEWARE_ALIAS	`'default'`
CACHE_MIDDLEWARE_KEY_PREFIX	`'********************'`
CACHE_MIDDLEWARE_SECONDS	`600`
CSRF_COOKIE_AGE	`31449600`
CSRF_COOKIE_DOMAIN	`None`
CSRF_COOKIE_HTTPONLY	`False`
CSRF_COOKIE_NAME	`'csrftoken'`
CSRF_COOKIE_PATH	`'/'`
CSRF_COOKIE_SAMESITE	`'Lax'`
CSRF_COOKIE_SECURE	`False`
CSRF_FAILURE_VIEW	`'django.views.csrf.csrf_failure'`
CSRF_HEADER_NAME	`'HTTP_X_CSRFTOKEN'`
CSRF_TRUSTED_ORIGINS	`[]`
CSRF_USE_SESSIONS	`False`
DATABASES	`{'default': {'ATOMIC_REQUESTS': False, 'AUTOCOMMIT': True, 'CONN_MAX_AGE': 0, 'ENGINE': 'django.db.backends.postgresql_psycopg2', 'HOST': 'localhost', 'NAME': 'protwis_202107', 'OPTIONS': {}, 'PASSWORD': '********************', 'PORT': '', 'TEST': {'CHARSET': None, 'COLLATION': None, 'MIRROR': None, 'NAME': None}, 'TIME_ZONE': None, 'USER': 'protwis'}}`
DATABASE_ROUTERS	`[]`
DATA_DIR	`'/home/protwis/gpcrdb_data'`
DATA_UPLOAD_MAX_MEMORY_SIZE	`2621440`
DATA_UPLOAD_MAX_NUMBER_FIELDS	`1000`
DATETIME_FORMAT	`'N j, Y, P'`
DATETIME_INPUT_FORMATS	`['%Y-%m-%d %H:%M:%S', '%Y-%m-%d %H:%M:%S.%f', '%Y-%m-%d %H:%M', '%Y-%m-%d', '%m/%d/%Y %H:%M:%S', '%m/%d/%Y %H:%M:%S.%f', '%m/%d/%Y %H:%M', '%m/%d/%Y', '%m/%d/%y %H:%M:%S', '%m/%d/%y %H:%M:%S.%f', '%m/%d/%y %H:%M', '%m/%d/%y']`
DATE_FORMAT	`'N j, Y'`
DATE_INPUT_FORMATS	`['%Y-%m-%d', '%m/%d/%Y', '%m/%d/%y', '%b %d %Y', '%b %d, %Y', '%d %b %Y', '%d %b, %Y', '%B %d %Y', '%B %d, %Y', '%d %B %Y', '%d %B, %Y']`
DEBUG	`True`
DEBUG_PROPAGATE_EXCEPTIONS	`False`
DEBUG_TOOLBAR_PATCH_SETTINGS	`False`
DECIMAL_SEPARATOR	`'.'`
DEFAULT_CHARSET	`'utf-8'`
DEFAULT_CONTENT_TYPE	`'text/html'`
DEFAULT_EXCEPTION_REPORTER_FILTER	`'django.views.debug.SafeExceptionReporterFilter'`
DEFAULT_FILE_STORAGE	`'django.core.files.storage.FileSystemStorage'`
DEFAULT_FROM_EMAIL	`'webmaster@localhost'`
DEFAULT_INDEX_TABLESPACE	`''`
DEFAULT_NUMBERING_SCHEME	`'gpcrdb'`
DEFAULT_PROTEIN_STATE	`'inactive'`
DEFAULT_SITE	`'gpcr'`
DEFAULT_TABLESPACE	`''`
DISALLOWED_USER_AGENTS	`[]`
DOCUMENTATION_URL	`'https://docs.gpcrdb.org/'`
EMAIL_BACKEND	`'django.core.mail.backends.smtp.EmailBackend'`
EMAIL_HOST	`'localhost'`
EMAIL_HOST_PASSWORD	`'********************'`
EMAIL_HOST_USER	`''`
EMAIL_PORT	`25`
EMAIL_SSL_CERTFILE	`None`
EMAIL_SSL_KEYFILE	`'********************'`
EMAIL_SUBJECT_PREFIX	`'[Django] '`
EMAIL_TIMEOUT	`None`
EMAIL_USE_LOCALTIME	`False`
EMAIL_USE_SSL	`False`
EMAIL_USE_TLS	`False`
FILE_CHARSET	`'utf-8'`
FILE_UPLOAD_DIRECTORY_PERMISSIONS	`None`
FILE_UPLOAD_HANDLERS	`['django.core.files.uploadhandler.MemoryFileUploadHandler', 'django.core.files.uploadhandler.TemporaryFileUploadHandler']`
FILE_UPLOAD_MAX_MEMORY_SIZE	`2621440`
FILE_UPLOAD_PERMISSIONS	`None`
FILE_UPLOAD_TEMP_DIR	`None`
FIRST_DAY_OF_WEEK	`0`
FIXTURE_DIRS	`[]`
FORCE_SCRIPT_NAME	`None`
FORMAT_MODULE_PATH	`None`
FORM_RENDERER	`'django.forms.renderers.DjangoTemplates'`
GOOGLE_ANALYTICS_API	`'********************'`
GOOGLE_ANALYTICS_KEY	`'********************'`
IGNORABLE_404_URLS	`[]`
INSTALLED_APPS	('django.contrib.admin', 'django.contrib.auth', 'django.contrib.contenttypes', 'django.contrib.sessions', 'django.contrib.messages', 'django.contrib.staticfiles', 'django.contrib.humanize', 'debug_toolbar', 'rest_framework', 'rest_framework_swagger', 'polymorphic', 'common', 'api', 'news', 'pages', 'home', 'protein', 'family', 'residue', 'alignment', 'similaritysearch', 'similaritymatrix', 'structure', 'ligand', 'interaction', 'mutation', 'phylogenetic_trees', 'sitesearch', 'build_gpcr', 'construct', 'tools', 'drugs', 'signprot', 'signprot2', 'mutational_landscape', 'contactnetwork', 'seqsign', 'angles', 'hotspots')
INTERNAL_IPS	`'10.0.2.2'`
LANGUAGES	[('af', 'Afrikaans'), ('ar', 'Arabic'), ('ast', 'Asturian'), ('az', 'Azerbaijani'), ('bg', 'Bulgarian'), ('be', 'Belarusian'), ('bn', 'Bengali'), ('br', 'Breton'), ('bs', 'Bosnian'), ('ca', 'Catalan'), ('cs', 'Czech'), ('cy', 'Welsh'), ('da', 'Danish'), ('de', 'German'), ('dsb', 'Lower Sorbian'), ('el', 'Greek'), ('en', 'English'), ('en-au', 'Australian English'), ('en-gb', 'British English'), ('eo', 'Esperanto'), ('es', 'Spanish'), ('es-ar', 'Argentinian Spanish'), ('es-co', 'Colombian Spanish'), ('es-mx', 'Mexican Spanish'), ('es-ni', 'Nicaraguan Spanish'), ('es-ve', 'Venezuelan Spanish'), ('et', 'Estonian'), ('eu', 'Basque'), ('fa', 'Persian'), ('fi', 'Finnish'), ('fr', 'French'), ('fy', 'Frisian'), ('ga', 'Irish'), ('gd', 'Scottish Gaelic'), ('gl', 'Galician'), ('he', 'Hebrew'), ('hi', 'Hindi'), ('hr', 'Croatian'), ('hsb', 'Upper Sorbian'), ('hu', 'Hungarian'), ('hy', 'Armenian'), ('ia', 'Interlingua'), ('id', 'Indonesian'), ('io', 'Ido'), ('is', 'Icelandic'), ('it', 'Italian'), ('ja', 'Japanese'), ('ka', 'Georgian'), ('kab', 'Kabyle'), ('kk', 'Kazakh'), ('km', 'Khmer'), ('kn', 'Kannada'), ('ko', 'Korean'), ('lb', 'Luxembourgish'), ('lt', 'Lithuanian'), ('lv', 'Latvian'), ('mk', 'Macedonian'), ('ml', 'Malayalam'), ('mn', 'Mongolian'), ('mr', 'Marathi'), ('my', 'Burmese'), ('nb', 'Norwegian Bokmål'), ('ne', 'Nepali'), ('nl', 'Dutch'), ('nn', 'Norwegian Nynorsk'), ('os', 'Ossetic'), ('pa', 'Punjabi'), ('pl', 'Polish'), ('pt', 'Portuguese'), ('pt-br', 'Brazilian Portuguese'), ('ro', 'Romanian'), ('ru', 'Russian'), ('sk', 'Slovak'), ('sl', 'Slovenian'), ('sq', 'Albanian'), ('sr', 'Serbian'), ('sr-latn', 'Serbian Latin'), ('sv', 'Swedish'), ('sw', 'Swahili'), ('ta', 'Tamil'), ('te', 'Telugu'), ('th', 'Thai'), ('tr', 'Turkish'), ('tt', 'Tatar'), ('udm', 'Udmurt'), ('uk', 'Ukrainian'), ('ur', 'Urdu'), ('vi', 'Vietnamese'), ('zh-hans', 'Simplified Chinese'), ('zh-hant', 'Traditional Chinese')]
LANGUAGES_BIDI	`['he', 'ar', 'fa', 'ur']`
LANGUAGE_CODE	`'en-us'`
LANGUAGE_COOKIE_AGE	`None`
LANGUAGE_COOKIE_DOMAIN	`None`
LANGUAGE_COOKIE_NAME	`'django_language'`
LANGUAGE_COOKIE_PATH	`'/'`
LOCALE_PATHS	`[]`
LOGGING	{'disable_existing_loggers': False, 'formatters': {'verbose': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s] %(message)s'}, 'verbose_low': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s]'}}, 'handlers': {'build': {'class': 'logging.FileHandler', 'filename': 'logs/build.log', 'formatter': 'verbose', 'level': 'DEBUG'}, 'django': {'class': 'logging.FileHandler', 'filename': 'logs/django.log', 'formatter': 'verbose', 'level': 'WARNING'}, 'protwis': {'class': 'logging.FileHandler', 'filename': 'logs/protwis.log', 'formatter': 'verbose', 'level': 'DEBUG'}}, 'loggers': {'build': {'handlers': ['build'], 'level': 'DEBUG'}, 'django': {'handlers': ['django'], 'level': 'WARNING', 'propagate': True}, 'protwis': {'handlers': ['protwis'], 'level': 'DEBUG'}}, 'version': 1}
LOGGING_CONFIG	`'logging.config.dictConfig'`
LOGIN_REDIRECT_URL	`'/accounts/profile/'`
LOGIN_URL	`'/accounts/login/'`
LOGOUT_REDIRECT_URL	`None`
MANAGERS	`[]`
MEDIA_ROOT	`'/protwis/media/protwis'`
MEDIA_URL	`'/media/'`
MESSAGE_STORAGE	`'django.contrib.messages.storage.fallback.FallbackStorage'`
MIDDLEWARE	`('common.middleware.stats.StatsMiddleware', 'debug_toolbar.middleware.DebugToolbarMiddleware', 'django.contrib.sessions.middleware.SessionMiddleware', 'django.middleware.common.CommonMiddleware', 'django.middleware.csrf.CsrfViewMiddleware', 'django.contrib.auth.middleware.AuthenticationMiddleware', 'django.contrib.messages.middleware.MessageMiddleware', 'django.middleware.clickjacking.XFrameOptionsMiddleware')`
MIGRATION_MODULES	`{}`
MONTH_DAY_FORMAT	`'F j'`
NUMBER_GROUPING	`0`
PASSWORD_HASHERS	`'********************'`
PASSWORD_RESET_TIMEOUT_DAYS	`'********************'`
PREPEND_WWW	`False`
REFERENCE_POSITIONS	`{'D1S1': 'D1S1x50', 'D1S2': 'D1S2x50', 'D1T1': 'D1T1x50', 'D1e1': 'D1e1x50', 'ECL1': '23x50', 'ECL2': '45x50', 'H8': '8x50', 'ICL1': '12x50', 'ICL2': '34x50', 'TM1': '1x50', 'TM2': '2x50', 'TM3': '3x50', 'TM4': '4x50', 'TM5': '5x50', 'TM6': '6x50', 'TM7': '7x50'}`
ROOT_URLCONF	`'protwis.urls'`
SECRET_KEY	`'********************'`
SECURE_BROWSER_XSS_FILTER	`False`
SECURE_CONTENT_TYPE_NOSNIFF	`False`
SECURE_HSTS_INCLUDE_SUBDOMAINS	`False`
SECURE_HSTS_PRELOAD	`False`
SECURE_HSTS_SECONDS	`0`
SECURE_PROXY_SSL_HEADER	`None`
SECURE_REDIRECT_EXEMPT	`[]`
SECURE_SSL_HOST	`None`
SECURE_SSL_REDIRECT	`False`
SERVER_EMAIL	`'root@localhost'`
SESSION_CACHE_ALIAS	`'default'`
SESSION_COOKIE_AGE	`86400`
SESSION_COOKIE_DOMAIN	`None`
SESSION_COOKIE_HTTPONLY	`True`
SESSION_COOKIE_NAME	`'sessionid'`
SESSION_COOKIE_PATH	`'/'`
SESSION_COOKIE_SAMESITE	`'Lax'`
SESSION_COOKIE_SECURE	`False`
SESSION_ENGINE	`'django.contrib.sessions.backends.db'`
SESSION_EXPIRE_AT_BROWSER_CLOSE	`False`
SESSION_FILE_PATH	`None`
SESSION_SAVE_EVERY_REQUEST	`False`
SESSION_SERIALIZER	`'django.contrib.sessions.serializers.PickleSerializer'`
SETTINGS_MODULE	`'protwis.settings'`
SHORT_DATETIME_FORMAT	`'m/d/Y P'`
SHORT_DATE_FORMAT	`'m/d/Y'`
SIGNING_BACKEND	`'django.core.signing.TimestampSigner'`
SILENCED_SYSTEM_CHECKS	`[]`
SITE_NAME	`'gpcr'`
SITE_TITLE	`'GPCRdb'`
STATICFILES_DIRS	`('/home/protwis/gpcrdb_test/static',)`
STATICFILES_FINDERS	`['django.contrib.staticfiles.finders.FileSystemFinder', 'django.contrib.staticfiles.finders.AppDirectoriesFinder']`
STATICFILES_STORAGE	`'django.contrib.staticfiles.storage.StaticFilesStorage'`
STATIC_ROOT	`'/home/protwis/static_test/'`
STATIC_URL	`'/static/'`
SWAGGER_SETTINGS	`{'USE_SESSION_AUTH': False}`
TEMPLATES	[{'APP_DIRS': True, 'BACKEND': 'django.template.backends.django.DjangoTemplates', 'DIRS': [], 'OPTIONS': {'context_processors': ['django.contrib.auth.context_processors.auth', 'django.template.context_processors.debug', 'django.template.context_processors.i18n', 'django.template.context_processors.media', 'django.template.context_processors.static', 'django.template.context_processors.tz', 'django.contrib.messages.context_processors.messages', 'protwis.context_processors.current_site', 'protwis.context_processors.canonical_tag', 'protwis.context_processors.documentation_url', 'protwis.context_processors.google_analytics', 'protwis.context_processors.site_title'], 'debug': True}}]
TEST_NON_SERIALIZED_APPS	`[]`
TEST_RUNNER	`'django.test.runner.DiscoverRunner'`
THOUSAND_SEPARATOR	`','`
TIME_FORMAT	`'P'`
TIME_INPUT_FORMATS	`['%H:%M:%S', '%H:%M:%S.%f', '%H:%M']`
TIME_ZONE	`'Europe/Copenhagen'`
USE_I18N	`True`
USE_L10N	`True`
USE_THOUSAND_SEPARATOR	`False`
USE_TZ	`True`
USE_X_FORWARDED_HOST	`False`
USE_X_FORWARDED_PORT	`False`
WSGI_APPLICATION	`None`
X_FRAME_OPTIONS	`'SAMEORIGIN'`
YEAR_MONTH_FORMAT	`'F Y'`

Key	Value
Accept	text/html,application/xhtml+xml,application/xml;q=0.9,/;q=0.8
Accept-Encoding	br,gzip
Accept-Language	en-US,en;q=0.5
Connection	close
Host	test.gpcrdb.org
User-Agent	CCBot/2.0 (https://commoncrawl.org/faq/)
X-Forwarded-For	3.236.207.90
X-Forwarded-Proto	https
X-Real-Ip	3.236.207.90

Key	Value
Content-Length	529503
Content-Type	text/html; charset=utf-8
Vary	Cookie
X-Frame-Options	SAMEORIGIN

Variation Browser

Residue

Diagrams

Versions

Time

Resource usage

Browser timing

Settings from `protwis.settings`

Headers

Request headers

Response headers

WSGI environ

Request

View information

No cookies

No session data

No GET data

No POST data

SQL queries from 1 connection

Key	Value
PATH_INFO	/mutational_landscape/protein/ACM2_human/
QUERY_STRING
REMOTE_ADDR
REQUEST_METHOD	GET
SCRIPT_NAME
SERVER_NAME	test.gpcrdb.org
SERVER_PORT	443
SERVER_PROTOCOL	HTTP/1.0
SERVER_SOFTWARE	gunicorn/19.9.0

Query		Timeline	Time (ms)
+	SELECT ••• "protein"."id", "protein"."parent_id", "protein"."family_id", "protein"."species_id", "protein"."source_id", "protein"."residue_numbering_scheme_id", "protein"."sequence_type_id", "protein"."entry_name", "protein"."accession", "protein"."name", "protein"."sequence" FROM "protein" WHERE "protein"."entry_name" = 'acm2_human'	0.5630476650212382%	2.42
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(89) proteins.append(Protein.objects.get(entry_name=protein.lower()))
+	SELECT ••• "residue_position_set"."id", "residue_position_set"."name", "residue_position_set"."set_type", "residue_position_set"."protein_group" FROM "residue_position_set" WHERE "residue_position_set"."name" = 'State (micro-)switches' 3 similar queries.	0.11248774509125513%	0.48
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(128) micro_switches_rset = ResiduePositionSet.objects.get(name="State (micro-)switches")
+	SELECT ••• "residue_generic_number_equivalent"."id", "residue_generic_number_equivalent"."default_generic_number_id", "residue_generic_number_equivalent"."scheme_id", "residue_generic_number_equivalent"."label" FROM "residue_generic_number_equivalent" INNER JOIN "residue_position_set_residue_position" ON ("residue_generic_number_equivalent"."id" = "residue_position_set_residue_position"."residuegenericnumberequivalent_id") WHERE "residue_position_set_residue_position"."residuepositionset_id" = 2 3 similar queries.	0.3677441390950826%	1.58
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(130) for residue in micro_switches_rset.residue_position.all():
+	SELECT ••• "residue"."id", "residue"."protein_conformation_id", "residue"."protein_segment_id", "residue"."generic_number_id", "residue"."display_generic_number_id", "residue"."sequence_number", "residue"."amino_acid" FROM "residue" INNER JOIN "residue_generic_number" ON ("residue"."generic_number_id" = "residue_generic_number"."id") INNER JOIN "protein_conformation" ON ("residue"."protein_conformation_id" = "protein_conformation"."id") WHERE ("residue_generic_number"."label" IN ('5x47', '5x50', '6x30', '6x44', '6x50', '6x48', '6x34', '5x58', '3x40', '3x49', '3x50', '7x53', '7x50', '7x49', '7x43') AND "protein_conformation"."protein_id" = 14) ORDER BY "residue"."sequence_number" ASC 2 similar queries. Duplicated 2 times.	1.930338420931135%	8.31
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(135) for ms in ms_object:
+	SELECT ••• "residue_position_set"."id", "residue_position_set"."name", "residue_position_set"."set_type", "residue_position_set"."protein_group" FROM "residue_position_set" WHERE "residue_position_set"."name" = 'Sodium ion pocket' 3 similar queries.	0.08436580881844136%	0.36
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(139) sodium_pocket_rset = ResiduePositionSet.objects.get(name="Sodium ion pocket")
+	SELECT ••• "residue_generic_number_equivalent"."id", "residue_generic_number_equivalent"."default_generic_number_id", "residue_generic_number_equivalent"."scheme_id", "residue_generic_number_equivalent"."label" FROM "residue_generic_number_equivalent" INNER JOIN "residue_position_set_residue_position" ON ("residue_generic_number_equivalent"."id" = "residue_position_set_residue_position"."residuegenericnumberequivalent_id") WHERE "residue_position_set_residue_position"."residuepositionset_id" = 3 3 similar queries.	0.24955450535008766%	1.07
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(141) for residue in sodium_pocket_rset.residue_position.all():
+	SELECT ••• "residue"."id", "residue"."protein_conformation_id", "residue"."protein_segment_id", "residue"."generic_number_id", "residue"."display_generic_number_id", "residue"."sequence_number", "residue"."amino_acid" FROM "residue" INNER JOIN "residue_generic_number" ON ("residue"."generic_number_id" = "residue_generic_number"."id") INNER JOIN "protein_conformation" ON ("residue"."protein_conformation_id" = "protein_conformation"."id") WHERE ("residue_generic_number"."label" IN ('5x47', '5x50', '6x30', '6x44', '6x50', '6x48', '6x34', '5x58', '3x40', '3x49', '3x50', '7x53', '7x50', '7x49', '7x43') AND "protein_conformation"."protein_id" = 14) ORDER BY "residue"."sequence_number" ASC 2 similar queries. Duplicated 2 times.	0.3095627315700289%	1.33
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(146) for sp in sp_object:
+	SELECT ••• "residue_ptm"."id", "residue_ptm"."protein_id", "residue_ptm"."residue_id", "residue_ptm"."modification" FROM "residue_ptm" WHERE "residue_ptm"."protein_id" IN (14)	0.1294826947679359%	0.56
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(149) for ptm in ptms:
+	SELECT ••• "residue"."id", "residue"."protein_conformation_id", "residue"."protein_segment_id", "residue"."generic_number_id", "residue"."display_generic_number_id", "residue"."sequence_number", "residue"."amino_acid" FROM "residue" WHERE "residue"."id" IN (5632, 6650, 6464, 6466, 6346, 6482, 6483, 6612, 6623, 6624, 6627, 6628, 6629, 6631, 6635, 6764, 6643, 5622, 6648, 5626, 6651, 6652) ORDER BY "residue"."sequence_number" ASC	0.6854998757209706%	2.95
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(149) for ptm in ptms:
+	SELECT ••• "residue_position_set"."id", "residue_position_set"."name", "residue_position_set"."set_type", "residue_position_set"."protein_group" FROM "residue_position_set" WHERE "residue_position_set"."name" = 'G-protein interface' 3 similar queries.	0.06449223574375601%	0.28
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(154) rset = ResiduePositionSet.objects.get(name='G-protein interface')
+	SELECT ••• "residue_generic_number_equivalent"."id", "residue_generic_number_equivalent"."default_generic_number_id", "residue_generic_number_equivalent"."scheme_id", "residue_generic_number_equivalent"."label" FROM "residue_generic_number_equivalent" INNER JOIN "residue_position_set_residue_position" ON ("residue_generic_number_equivalent"."id" = "residue_position_set_residue_position"."residuegenericnumberequivalent_id") WHERE "residue_position_set_residue_position"."residuepositionset_id" = 1 3 similar queries.	0.23992218859522624%	1.03
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(156) for residue in rset.residue_position.all():
+	SELECT ••• "protein_family"."id", "protein_family"."parent_id", "protein_family"."slug", "protein_family"."name" FROM "protein_family" WHERE "protein_family"."id" = 20	0.1097198379777892%	0.47
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(163) orthologs = Protein.objects.filter(family__slug=proteins[0].family.slug, sequence_type__slug='wt')
+	SELECT ••• "interaction_residue_fragment"."id", "interaction_residue_fragment"."structure_ligand_pair_id", "interaction_residue_fragment"."rotamer_id", "interaction_residue_fragment"."fragment_id", "interaction_residue_fragment"."interaction_type_id" FROM "interaction_residue_fragment" INNER JOIN "interaction_structure_ligand" ON ("interaction_residue_fragment"."structure_ligand_pair_id" = "interaction_structure_ligand"."id") INNER JOIN "structure" ON ("interaction_structure_ligand"."structure_id" = "structure"."id") INNER JOIN "protein_conformation" ON ("structure"."protein_conformation_id" = "protein_conformation"."id") INNER JOIN "protein" ON ("protein_conformation"."protein_id" = "protein"."id") INNER JOIN "interaction_type_residue_fragment" ON ("interaction_residue_fragment"."interaction_type_id" = "interaction_type_residue_fragment"."id") WHERE ("interaction_structure_ligand"."annotated" = true AND "protein"."parent_id" IN (SELECT ••• U0."id" FROM "protein" U0 INNER JOIN "protein_family" U1 ON (U0."family_id" = U1."id") INNER JOIN "protein_sequence_type" U2 ON (U0."sequence_type_id" = U2."id") WHERE (U1."slug" = '001_001_002_002' AND U2."slug" = 'wt')) AND NOT ("interaction_type_residue_fragment"."type" = 'hidden' AND "interaction_type_residue_fragment"."type" IS NOT NULL))	47.12428290446458%	202.96
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(170) for interaction in interactions:
+	SELECT ••• "structure_rotamer"."id", "structure_rotamer"."residue_id", "structure_rotamer"."structure_id", "structure_rotamer"."pdbdata_id", "structure_rotamer"."missing_atoms" FROM "structure_rotamer" WHERE "structure_rotamer"."id" = 86755 103 similar queries.	0.9003448258681955%	3.88
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(171) if interaction.rotamer.residue.generic_number:
+	SELECT ••• "residue"."id", "residue"."protein_conformation_id", "residue"."protein_segment_id", "residue"."generic_number_id", "residue"."display_generic_number_id", "residue"."sequence_number", "residue"."amino_acid" FROM "residue" WHERE "residue"."id" = 23640039 103 similar queries.	0.7920089414471393%	3.41
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(171) if interaction.rotamer.residue.generic_number:
+	SELECT ••• "residue_generic_number"."id", "residue_generic_number"."scheme_id", "residue_generic_number"."protein_segment_id", "residue_generic_number"."label" FROM "residue_generic_number" WHERE "residue_generic_number"."id" = 30722 99 similar queries. Duplicated 10 times.	0.11093771710771422%	0.48
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(171) if interaction.rotamer.residue.generic_number:
+	SELECT ••• "interaction_type_residue_fragment"."id", "interaction_type_residue_fragment"."slug", "interaction_type_residue_fragment"."name", "interaction_type_residue_fragment"."type", "interaction_type_residue_fragment"."direction" FROM "interaction_type_residue_fragment" WHERE "interaction_type_residue_fragment"."id" = 12 99 similar queries. Duplicated 7 times.	0.1021911306291619%	0.44
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(176) interactiontype = interaction.interaction_type.name
+	SELECT ••• "structure_rotamer"."id", "structure_rotamer"."residue_id", "structure_rotamer"."structure_id", "structure_rotamer"."pdbdata_id", "structure_rotamer"."missing_atoms" FROM "structure_rotamer" WHERE "structure_rotamer"."id" = 89160 103 similar queries.	0.5578439996479222%	2.40
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(171) if interaction.rotamer.residue.generic_number:
+	SELECT ••• "residue"."id", "residue"."protein_conformation_id", "residue"."protein_segment_id", "residue"."generic_number_id", "residue"."display_generic_number_id", "residue"."sequence_number", "residue"."amino_acid" FROM "residue" WHERE "residue"."id" = 23640090 103 similar queries.	0.09549279541457435%	0.41
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(171) if interaction.rotamer.residue.generic_number:
+	SELECT ••• "residue_generic_number"."id", "residue_generic_number"."scheme_id", "residue_generic_number"."protein_segment_id", "residue_generic_number"."label" FROM "residue_generic_number" WHERE "residue_generic_number"."id" = 50465 99 similar queries. Duplicated 3 times.	0.07528707348627312%	0.32
	Connection: default /usr/lib/python3.6/concurrent/futures/thread.py in _worker(69) work_item.run() /usr/lib/python3.6/concurrent/futures/thread.py in run(56) result = self.fn(self.args, *self.kwargs) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279) keepalive = self.handle_request(req, conn) /home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328) respiter = self.wsgi(environ, resp.start_response) /home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34) response = self.get_response(request) /home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(171) if interaction.rotamer.residue.generic_number:

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