Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
grm5_human 1181 C-term N => GlnfsTer18 frameshift 9.102e-06 1 109864 0 None None
grm5_human 1169 C-term F => SerfsTer34 frameshift 1.222e-05 1 81834 0 None None
grm5_human 1149 C-term E => Ter stop gained 0.0003102 2 6448 0 None None
grm5_human 533 N-term T => AspfsTer6 frameshift 8.24e-06 1 121358 0 None None
grm5_human 469 N-term M => GlufsTer11 frameshift 1.157e-05 1 86458 0 None None
grm5_human 366 N-term R => Ter stop gained 8.271e-06 1 120902 0 None None
grm5_human 268 N-term L => Ter stop gained 3.68e-05 1 27174 0 None None
grm5_human 67 N-term Q => HisfsTer4 frameshift 4.244e-05 1 23562 0 None None
grm5_human 1207 C-term Q => E missense 8.639e-06 1 115754 0 nan 0.895
grm5_human 1206 C-term T => S missense 8.631e-06 1 115866 0 nan 0.007
grm5_human 1200 C-term L => P missense 0.0006885 80 116192 0 nan 0.984
grm5_human 1193 C-term S => L missense 8.623e-06 1 115974 0 nan 0.558
grm5_human 1190 C-term C => Y missense 1.729e-05 2 115644 0 nan 0.958
grm5_human 1188 C-term A => T missense 8.696e-06 1 114998 0 nan 0.697
grm5_human 1184 C-term V => E missense 8.832e-06 1 113220 0 nan 0.312
grm5_human 1180 C-term P => L missense 9.136e-06 1 109462 0 nan 0.932
grm5_human 1174 C-term D => A missense 4.2e-05 4 95236 0 1.0 0.004
grm5_human 1173 C-term V => A missense 1.069e-05 1 93576 0 nan 0.047
grm5_human 1161 C-term V => L missense 1.912e-05 1 52310 0 1.0 0.005
grm5_human 1159 C-term E => D missense 3.97e-05 2 50374 0 1.0 0.034
grm5_human 1149 C-term E => V missense 0.0002177 2 9186 0 nan 0.058
grm5_human 1148 C-term P => T missense 0.000159 1 6290 0 nan 0.009
grm5_human 1146 C-term A => S missense 0.0003973 2 5034 0 nan 0.022
grm5_human 1141 C-term R => Q missense 0.0001259 1 7940 0 nan 0.016
grm5_human 1140 C-term A => T missense 0.0001073 1 9318 0 nan 0.025
grm5_human 1139 C-term A => V missense 9.917e-05 1 10084 0 nan 0.054
grm5_human 1136 C-term A => S missense 7.233e-05 1 13826 0 nan 0.003
grm5_human 1134 C-term Q => R missense 6.316e-05 1 15834 0 nan 0.0
grm5_human 1130 C-term A => V missense 9.91e-05 2 20182 0 nan 0.012
grm5_human 1130 C-term A => T missense 4.857e-05 1 20588 0 nan 0.008
grm5_human 1127 C-term A => P missense 0.0001976 5 25302 0 nan 0.003
grm5_human 1127 C-term A => T missense 7.905e-05 2 25302 0 nan 0.003
grm5_human 1123 C-term V => I missense 1.645e-05 1 60794 0 nan 0.076
grm5_human 1122 C-term E => K missense 3.304e-05 2 60534 0 nan 0.315
grm5_human 1119 C-term P => S missense 3.318e-05 2 60286 0 nan 0.023
grm5_human 1115 C-term I => V missense 1.634e-05 1 61206 0 nan 0.015
grm5_human 1110 C-term T => A missense 1.628e-05 1 61416 0 nan 0.997
grm5_human 1108 C-term T => A missense 1.635e-05 1 61180 0 nan 0.539
grm5_human 1107 C-term T => K missense 4.932e-05 3 60826 0 nan 0.355
grm5_human 1107 C-term T => A missense 4.929e-05 3 60860 0 nan 0.153
grm5_human 1102 C-term E => Q missense 1.739e-05 1 57506 0 nan 0.549
grm5_human 1099 C-term I => S missense 1.812e-05 1 55174 0 nan 0.007
grm5_human 1096 C-term S => T missense 1.923e-05 1 52014 0 nan 0.01
grm5_human 1091 C-term A => S missense 2.199e-05 1 45478 0 nan 0.061
grm5_human 1088 C-term G => C missense 2.35e-05 1 42556 0 nan 0.378
grm5_human 1086 C-term S => R missense 5.001e-05 2 39996 0 nan 0.116
grm5_human 1085 C-term P => L missense 2.551e-05 1 39198 0 nan 0.052
grm5_human 1085 C-term P => S missense 0.0001039 4 38506 0 nan 0.085
grm5_human 1043 C-term H => P missense 0.0004139 6 14498 0 nan 0.058
grm5_human 1040 C-term P => L missense 0.0005766 8 13874 0 nan 0.084
grm5_human 1031 C-term S => W missense 8.498e-05 1 11768 0 nan 0.911
grm5_human 1029 C-term A => V missense 8.64e-05 1 11574 0 nan 0.071
grm5_human 1017 C-term R => H missense 9.42e-05 1 10616 0 nan 0.467
grm5_human 1014 C-term A => E missense 9.438e-05 1 10596 0 nan 0.17
grm5_human 1001 C-term Y => F missense 0.0003782 4 10576 0 nan 0.686 PTM (Phosphorylation)
grm5_human 980 C-term A => V missense 0.0001643 2 12170 0 nan 0.011
grm5_human 980 C-term A => E missense 8.217e-05 1 12170 0 nan 0.321
grm5_human 980 C-term A => T missense 7.744e-05 1 12914 0 nan 0.08
grm5_human 978 C-term G => S missense 0.004681 81 17304 1 nan 0.118
grm5_human 974 C-term V => L missense 2.47e-05 1 40484 0 nan 0.001
grm5_human 973 C-term G => S missense 0.0003872 20 51648 0 nan 0.003
grm5_human 969 C-term G => V missense 1.162e-05 1 86034 0 nan 0.0 LB (polar (hydrogen bond))
grm5_human 969 C-term G => R missense 1.133e-05 1 88282 0 nan 0.001 LB (polar (hydrogen bond))
grm5_human 967 C-term A => V missense 1.026e-05 1 97434 0 nan 0.021
grm5_human 965 C-term A => S missense 6.731e-05 7 103990 0 nan 0.003
grm5_human 963 C-term A => P missense 0.0001584 17 107290 0 nan 0.238
grm5_human 962 C-term G => R missense 9.218e-06 1 108486 0 nan 0.3
grm5_human 957 C-term E => Q missense 8.963e-06 1 111572 0 1.0 0.203
grm5_human 954 C-term K => R missense 8.875e-06 1 112678 0 nan 0.996
grm5_human 948 C-term V => I missense 8.785e-06 1 113826 0 nan 0.089 LB (aromatic (face-to-edge))
grm5_human 946 C-term T => K missense 8.771e-06 1 114016 0 nan 0.999
grm5_human 939 C-term K => R missense 8.73e-06 1 114548 0 nan 0.993
grm5_human 939 C-term K => Q missense 8.73e-06 1 114550 0 nan 0.997
grm5_human 938 C-term N => S missense 9.6e-05 11 114586 0 nan 0.167
grm5_human 932 C-term R => H missense 8.72e-06 1 114674 0 nan 0.999
grm5_human 930 C-term W => G missense 8.715e-06 1 114744 0 nan 0.997
grm5_human 928 C-term H => Q missense 8.715e-06 1 114744 0 nan 0.572
grm5_human 925 C-term R => Q missense 2.617e-05 3 114618 0 nan 0.228
grm5_human 925 C-term R => G missense 8.726e-06 1 114606 0 nan 0.344
grm5_human 924 C-term S => T missense 8.727e-06 1 114586 0 0.15 0.028
grm5_human 922 C-term K => M missense 1.745e-05 2 114582 0 nan 0.751
grm5_human 915 C-term V => I missense 1.756e-05 2 113902 0 nan 0.994
grm5_human 911 C-term N => S missense 3.539e-05 4 113042 0 nan 0.994
grm5_human 905 C-term A => E missense 8.4e-06 1 119054 0 nan 0.027
grm5_human 905 C-term A => P missense 8.397e-06 1 119084 0 nan 0.135
grm5_human 899 C-term M => V missense 4.184e-05 5 119492 0 nan 0.0
grm5_human 895 C-term P => R missense 8.363e-06 1 119574 0 nan 0.697
grm5_human 888 C-term S => L missense 7.535e-05 9 119436 0 nan 0.01 PTM (Phosphorylation)
grm5_human 884 C-term A => P missense 5.039e-05 6 119080 0 0.23 0.064
grm5_human 883 C-term L => Q missense 8.403e-06 1 119000 0 0.01 0.047
grm5_human 875 C-term T => N missense 8.872e-06 1 112716 0 0.48 0.02
grm5_human 871 C-term S => F missense 0.000197 23 116766 0 0.02 0.998
grm5_human 865 C-term L => V missense 8.326e-06 1 120104 0 0.03 0.996
grm5_human 862 C-term L => I missense 3.317e-05 4 120584 0 0.18 0.487
grm5_human 856 C-term A => G missense 8.261e-06 1 121046 0 0.12 0.345
grm5_human 855 C-term A => T missense 4.129e-05 5 121092 0 0.29 0.691
grm5_human 847 C-term V => I missense 1.649e-05 2 121266 0 0.21 0.99
grm5_human 842 C-term V => M missense 5.771e-05 7 121298 0 0.01 0.999
grm5_human 841 C-term T => N missense 8.244e-06 1 121306 0 0.2 0.997 PTM (Phosphorylation (PRKCA))
grm5_human 836 8.53x53 H8 A => V missense 8.243e-06 1 121316 0 0.02 0.997
grm5_human 820 7.50x50 TM7 P => Q missense 8.242e-06 1 121330 0 0.01 1.0 GP (contact)
grm5_human 820 7.50x50 TM7 P => L missense 8.242e-06 1 121330 0 0.0 1.0 GP (contact)
grm5_human 815 7.45x46 TM7 G => A missense 8.243e-06 1 121320 0 1.0 0.519
grm5_human 814 7.44x45 TM7 L => P missense 8.243e-06 1 121320 0 0.0 1.0 SodiumPocket MicroSwitch
grm5_human 775 6.40x40 TM6 A => T missense 8.238e-06 1 121394 0 0.0 0.96
grm5_human 769 ICL3 N => I missense 8.238e-06 1 121388 0 0.0 0.998
grm5_human 766 ICL3 A => T missense 8.238e-06 1 121384 0 0.01 0.99
grm5_human 761 5.61x61 TM5 T => S missense 8.239e-06 1 121380 0 0.02 0.978 GP (contact)
grm5_human 736 5.36x36 TM5 T => S missense 8.239e-06 1 121374 0 1.0 0.771
grm5_human 734 45.51x51 ECL2 N => T missense 8.239e-06 1 121372 0 0.03 0.999
grm5_human 729 ECL2 V => A missense 8.238e-06 1 121382 0 0.0 0.997
grm5_human 726 ECL2 I => V missense 8.239e-06 1 121378 0 0.16 0.994
grm5_human 725 ECL2 S => N missense 8.239e-06 1 121372 0 0.02 0.998
grm5_human 719 ECL2 I => T missense 8.24e-06 1 121366 0 0.2 0.257
grm5_human 715 4.54x54 TM4 E => G missense 8.24e-06 1 121366 0 0.0 0.999
grm5_human 714 4.53x53 TM4 M => I missense 8.24e-06 1 121366 0 0.21 0.029
grm5_human 714 4.53x53 TM4 M => V missense 1.648e-05 2 121364 0 0.02 0.052
grm5_human 711 4.50x50 TM4 L => I missense 8.24e-06 1 121362 0 0.04 0.999
grm5_human 709 4.48x48 TM4 V => I missense 0.000445 54 121360 2 0.49 0.144
grm5_human 699 4.38x38 TM4 I => L missense 1.648e-05 2 121348 0 0.25 0.018
grm5_human 695 4.34x34 TM4 V => A missense 8.241e-06 1 121350 0 0.01 0.741
grm5_human 690 4.29x29 TM4 A => V missense 8.242e-06 1 121326 0 0.0 0.999
grm5_human 690 4.29x29 TM4 A => S missense 8.242e-06 1 121336 0 0.03 0.999
grm5_human 689 4.28x28 TM4 S => I missense 8.242e-06 1 121328 0 0.0 1.0
grm5_human 679 ICL2 K => E missense 8.247e-06 1 121258 0 0.0 0.998
grm5_human 670 3.55x55 TM3 A => T missense 8.255e-06 1 121146 0 0.0 1.0
grm5_human 668 3.53x53 TM3 R => H missense 8.256e-06 1 121122 0 0.0 1.0 SodiumPocket MicroSwitch
grm5_human 663 3.48x48 TM3 V => A missense 8.258e-06 1 121100 0 0.06 0.997
grm5_human 657 3.42x42 TM3 M => V missense 8.259e-06 1 121076 0 0.08 0.989
grm5_human 652 3.37x37 TM3 G => C missense 1.653e-05 2 121018 0 0.04 1.0
grm5_human 650 3.35x35 TM3 G => V missense 8.262e-06 1 121032 0 0.29 1.0
grm5_human 644 3.29x29 TM3 C => Y missense 8.259e-06 1 121082 0 0.0 1.0
grm5_human 638 ECL1 K => E missense 8.254e-06 1 121156 0 0.01 0.998
grm5_human 637 ECL1 A => V missense 8.253e-06 1 121164 0 0.0 0.941
grm5_human 635 2.56x56 TM2 L => F missense 8.25e-06 1 121216 0 0.0 1.0
grm5_human 630 2.51x51 TM2 L => F missense 8.247e-06 1 121256 0 0.06 1.0
grm5_human 628 2.49x49 TM2 G => S missense 8.245e-06 1 121288 0 0.19 1.0
grm5_human 620 2.41x41 TM2 I => L missense 8.244e-06 1 121298 0 0.06 0.994
grm5_human 620 2.41x41 TM2 I => F missense 8.244e-06 1 121298 0 0.0 0.999
grm5_human 616 2.37x37 TM2 E => K missense 8.245e-06 1 121290 0 0.0 1.0
grm5_human 605 ICL1 R => H missense 1.65e-05 2 121230 0 0.14 0.052
grm5_human 605 ICL1 R => C missense 3.3e-05 4 121228 0 0.01 0.962
grm5_human 603 1.63x63 TM1 I => M missense 8.25e-06 1 121208 0 0.28 0.016
grm5_human 591 1.51x51 TM1 L => F missense 8.272e-06 1 120886 0 0.08 0.986
grm5_human 590 1.50x50 TM1 G => D missense 8.273e-06 1 120874 0 0.0 1.0
grm5_human 585 1.45x45 TM1 V => A missense 8.3e-06 1 120480 0 0.22 0.221
grm5_human 582 1.42x42 TM1 A => S missense 8.349e-06 1 119776 0 0.0 0.996
grm5_human 571 N-term Q => R missense 1.783e-05 2 112192 0 0.44 0.08
grm5_human 560 N-term D => G missense 8.255e-06 1 121132 0 0.19 0.05
grm5_human 553 N-term Q => H missense 8.249e-06 1 121232 0 0.04 0.516
grm5_human 552 N-term C => Y missense 8.248e-06 1 121248 0 0.0 1.0
grm5_human 551 N-term A => S missense 8.246e-06 1 121270 0 0.05 0.999
grm5_human 550 N-term K => N missense 8.246e-06 1 121266 0 0.01 0.524
grm5_human 535 N-term T => I missense 8.24e-06 1 121352 0 0.03 0.999
grm5_human 529 N-term S => G missense 8.241e-06 1 121346 0 0.0 0.924
grm5_human 513 N-term E => D missense 8.358e-06 1 119650 0 0.14 0.084
grm5_human 506 N-term I => N missense 8.273e-06 1 120882 0 0.06 0.534
grm5_human 504 N-term S => R missense 8.268e-06 1 120946 0 0.04 0.101
grm5_human 504 N-term S => N missense 8.268e-06 1 120950 0 0.14 0.015
grm5_human 498 N-term E => Q missense 8.27e-06 1 120924 0 0.24 0.997
grm5_human 497 N-term D => A missense 8.269e-06 1 120936 0 0.47 0.171
grm5_human 497 N-term D => V missense 8.269e-06 1 120936 0 0.18 0.432
grm5_human 495 N-term D => N missense 8.274e-06 1 120856 0 0.24 0.005
grm5_human 492 N-term L => I missense 8.29e-06 1 120622 0 0.02 0.999
grm5_human 482 N-term I => V missense 8.668e-06 1 115366 0 1.0 0.015
grm5_human 478 N-term Y => F missense 3.641e-05 4 109858 0 0.08 0.438
grm5_human 476 N-term K => E missense 9.68e-06 1 103306 0 0.82 0.017
grm5_human 475 N-term G => R missense 9.892e-06 1 101096 0 0.07 0.964
grm5_human 474 N-term M => T missense 2.031e-05 2 98454 0 0.61 0.012
grm5_human 473 N-term E => Q missense 2.095e-05 2 95486 0 0.63 0.004
grm5_human 458 N-term E => Q missense 8.324e-06 1 120134 0 0.24 0.113
grm5_human 453 N-term T => M missense 0.00726 874 120390 28 0.2 0.051
grm5_human 453 N-term T => R missense 8.306e-06 1 120390 0 0.45 0.389
grm5_human 437 N-term L => R missense 8.258e-06 1 121096 0 0.0 1.0
grm5_human 437 N-term L => V missense 8.257e-06 1 121108 0 0.0 0.999
grm5_human 435 N-term R => Q missense 2.477e-05 3 121122 0 0.08 0.016
grm5_human 435 N-term R => L missense 8.256e-06 1 121122 0 0.01 0.12
grm5_human 435 N-term R => W missense 2.477e-05 3 121134 0 0.0 0.881
grm5_human 432 N-term I => T missense 8.252e-06 1 121188 0 0.0 0.948
grm5_human 416 N-term M => I missense 1.649e-05 2 121268 0 0.06 0.048
grm5_human 414 N-term M => V missense 8.245e-06 1 121280 0 0.0 0.99
grm5_human 383 N-term S => G missense 2.499e-05 3 120050 0 1.0 0.396
grm5_human 375 N-term S => N missense 4.143e-05 5 120700 0 0.41 0.009
grm5_human 375 N-term S => G missense 8.283e-06 1 120730 0 0.39 0.122
grm5_human 370 N-term F => S missense 8.276e-06 1 120828 0 0.17 0.011
grm5_human 369 N-term G => V missense 2.482e-05 3 120862 0 0.09 1.0
grm5_human 366 N-term R => Q missense 2.482e-05 3 120894 0 0.2 0.08
grm5_human 364 N-term Q => R missense 8.27e-06 1 120924 0 0.0 0.472
grm5_human 350 N-term H => N missense 8.265e-06 1 120986 0 0.13 0.143
grm5_human 347 N-term E => K missense 8.266e-06 1 120978 0 0.07 0.676
grm5_human 345 N-term R => Q missense 1.653e-05 2 120994 0 0.09 0.008
grm5_human 333 N-term D => N missense 2.479e-05 3 121010 0 0.27 0.713
grm5_human 332 N-term P => S missense 2.479e-05 3 121010 0 0.04 0.29
grm5_human 322 N-term V => L missense 8.269e-06 1 120940 0 0.29 0.257
grm5_human 315 N-term D => Y missense 8.277e-06 1 120822 0 0.0 0.959
grm5_human 304 N-term S => I missense 8.3e-06 1 120478 0 0.0 0.997
grm5_human 298 N-term E => D missense 0.0001489 18 120856 0 0.02 0.292
grm5_human 296 N-term A => E missense 8.263e-06 1 121022 0 0.21 0.373
grm5_human 295 N-term L => V missense 3.303e-05 4 121088 0 1.0 0.566
grm5_human 294 N-term G => R missense 3.303e-05 4 121110 0 0.37 0.028
grm5_human 292 N-term R => C missense 8.252e-06 1 121182 0 0.0 1.0
grm5_human 290 N-term M => V missense 8.248e-06 1 121240 0 0.05 0.909
grm5_human 282 N-term T => M missense 8.245e-06 1 121288 0 0.0 1.0 PTM (Phosphorylation)
grm5_human 281 N-term M => T missense 8.243e-06 1 121314 0 0.02 0.987
grm5_human 271 N-term A => V missense 8.253e-06 1 121174 0 0.03 0.885
grm5_human 263 N-term K => R missense 4.16e-05 5 120190 0 0.24 0.007
grm5_human 213 N-term Y => F missense 8.399e-06 1 119058 0 0.01 0.828
grm5_human 210 N-term N => S missense 8.344e-06 1 119852 0 0.02 0.493
grm5_human 197 N-term Q => K missense 8.244e-06 1 121302 0 0.02 0.994
grm5_human 189 N-term M => V missense 8.241e-06 1 121344 0 0.02 0.989
grm5_human 167 N-term I => V missense 8.242e-06 1 121336 0 0.0 0.992
grm5_human 147 N-term I => V missense 8.241e-06 1 121350 0 0.16 0.985
grm5_human 146 N-term V => I missense 8.24e-06 1 121352 0 0.05 0.546
grm5_human 144 N-term V => A missense 8.241e-06 1 121348 0 0.5 0.997
grm5_human 138 N-term R => H missense 1.648e-05 2 121356 0 0.06 0.055
grm5_human 138 N-term R => C missense 8.24e-06 1 121352 0 0.02 0.863
grm5_human 137 N-term F => L missense 8.24e-06 1 121358 0 0.68 0.002
grm5_human 136 N-term S => P missense 8.24e-06 1 121356 0 0.38 0.01
grm5_human 130 N-term V => M missense 2.472e-05 3 121358 0 0.12 0.767
grm5_human 128 N-term R => H missense 2.472e-05 3 121360 0 0.09 0.937
grm5_human 125 N-term G => V missense 8.241e-06 1 121346 0 0.01 0.678
grm5_human 122 N-term E => G missense 8.241e-06 1 121338 0 0.05 0.083
grm5_human 121 N-term E => D missense 8.242e-06 1 121330 0 1.0 0.046
grm5_human 121 N-term E => K missense 8.242e-06 1 121324 0 0.05 0.699
grm5_human 119 N-term S => F missense 1.649e-05 2 121318 0 0.0 0.974
grm5_human 115 N-term D => E missense 0.0001319 16 121300 0 0.03 0.994
grm5_human 98 N-term S => Y missense 8.255e-06 1 121146 0 0.0 1.0 PTM (Phosphorylation)
grm5_human 87 N-term P => L missense 8.273e-06 1 120878 0 0.0 1.0
grm5_human 80 N-term N => S missense 8.284e-06 1 120716 0 0.0 0.999
grm5_human 76 N-term L => V missense 8.292e-06 1 120604 0 0.16 0.997
grm5_human 65 N-term G => D missense 8.267e-06 1 120964 0 0.0 1.0
grm5_human 61 N-term R => H missense 8.261e-06 1 121050 0 0.01 0.997
grm5_human 59 N-term A => V missense 8.256e-06 1 121120 0 0.02 0.347
grm5_human 45 N-term H => Q missense 8.249e-06 1 121222 0 0.06 0.981
grm5_human 35 N-term I => M missense 2.476e-05 3 121182 0 0.01 0.828
grm5_human 31 N-term M => V missense 8.254e-06 1 121160 0 0.04 0.046
grm5_human 28 N-term V => M missense 8.255e-06 1 121142 0 0.0 0.843
grm5_human 27 N-term V => M missense 8.255e-06 1 121146 0 0.05 0.999
grm5_human 19 N-term S => G missense 8.271e-06 1 120898 0 0.23 0.138
grm5_human 17 N-term R => H missense 2.484e-05 3 120790 0 0.05 0.389
grm5_human 14 N-term E => G missense 3.316e-05 4 120640 0 0.24 0.0
grm5_human 9 N-term V => I missense 8.331e-06 1 120040 0 0.16 0.001
grm5_human 2 N-term V => A missense 6.768e-05 8 118198 0 nan 0.0


Residue

Diagrams

ICL1 T R D P V V K S S ICL1ECL1 A K P ECL1ICL2 A G S K K K I C T K K P R F M ICL2ECL2 P P D I M H D Y P S I R E V Y L I C N T ECL2ICL3 R N V P A N F N ICL3ECL3 N ECL3N-term M V L L L I L S V L L L K E D V R G S A Q S S E R R V V A H M P G D I I I G A L F S V H H Q P T V D K V H E R K C G A V R E Q Y G I Q R V E A M L H T L E R I N S D P T L L P N I T L G C E I R D S C W H S A V A L E Q S I E F I R D S L I S S E E E E G L V R C V D G S S S S F R S K K P I V G V I G P G S S S V A I Q V Q N L L Q L F N I P Q I A Y S A T S M D L S D K T L F K Y F M R V V P S D A Q Q A R A M V D I V K R Y N W T Y V S A V H T E G N Y G E S G M E A F K D M S A K E G I C I A H S Y K I Y S N A G E Q S F D K L L K K L T S H L P K A R V V A C F C E G M T V R G L L M A M R R L G L A G E F L L L G S D G W A D R Y D V T D G Y Q R E A V G G I T I K L Q S P D V K W F D D Y Y L K L R P E T N H R N P W F Q E F W Q H R F Q C R L E G F P Q E N S K Y N K T C N S S L T L K T H H V Q D S K M G F V I N A I Y S M A Y G L H N M Q M S L C P G Y A G L C D A M K P I D G R K L L E S L M K T N F T G V S G D T I L F D E N G D S P G R Y E I M N F K E M G K D Y F D Y I N V G S W D N G E L K M D D D E V W S K K S N I I R S V C S E P C E K G Q I K V I R K G E V S C C W T C T P C K E N E Y V F D E Y T C K A C Q L G S W P T D D L T G C D L I P V Q Y L R W G D N-termC-term T V V R M H V G D G K S S S A A S R S S S L V N L W K R R G S S G E T L R Y K D R R L A Q H K S E I E C F T P K G S M G N G G R A T M S S S N G K S V T W A Q N E K S S R G Q H L W Q R L S I H I N K K E N P N Q T A V I K P F P K S T E S R G L G A G A G A G G S A G G V G A T G G A G C A G A G P G G P E S P D A G P K A L Y D V A E A E E H F P A P A R P R S P S P I S T L S H R A G S A S R T D D D V P S L H S E P V A R S S S S Q G S L M E Q I S S V V T R F T A N I S E L N S M M L S T A A P S P G V G A P L C S S Y L I P K E I Q L P T T M T T F A E I Q P L P A I E V T G G A Q P A A G A Q A A G D A A R E S P A A G P E A A A A K P D L E E L V A L T P P S P F R D S V D S G S T T P N S P V S E S A L C I P S S P K Y D T L I I R D Y T Q S S S S L C-term P E P I A A V V F A C L G L L A T L F V T V V F I I Y S R E L C Y I I L A G I C L G Y L C T F C L I K Q I Y C Y L Q R I G I G L S P A M S Y S A L V T K T N R I A R I L S A C A Q L V I A F I L I C I Q L G I I V A L F I M E T N L G V V T P L G Y N G L L I L S C T F Y A F K T E A K Y I A F T M Y T T C I I W L A F V P I Y F G S Y K I I T M C F S V S L S A T V A L G C M F V P K V Y I I L A K P E R A F T N V R S T S
SnakePlot Download: PNG | SVG L T A L L G L C A F V V A A I P E P 1 Y I I L A G I C L G Y L C T F C L I 2 T V L A S Y S M A P S L G I G I R Q L Y 3 Q L V I A F I L I C I Q L G I I V A L F 4 A Y F T C S L I L L G N Y G L P T V V G 5 A F T M Y T T C I I W L A F V P I Y F G 6 G L A V T A S L S V S F C M T I I K Y 7
HelixBox Download: PNG | SVG




«

Versions

Package Name Version
Django 2.2.1
Python 3.6.7
debug_toolbar Debug Toolbar 1.11
polymorphic Polymorphic 2.0.3
rest_framework Django REST framework 3.9.3
rest_framework_swagger Rest_Framework_Swagger 2.2.0

Time

Resource usage

Resource Value
User CPU time 3922.407 msec
System CPU time 135.404 msec
Total CPU time 4057.811 msec
Elapsed time 4408.121 msec
Context switches 242 voluntary, 44 involuntary

Browser timing

Timing attribute Timeline Milliseconds since navigation start (+length)

Settings from protwis.settings

Setting Value
ABSOLUTE_URL_OVERRIDES {}
ADMINS []
ALLOWED_HOSTS ['*']
APPEND_SLASH True
AUTHENTICATION_BACKENDS ['django.contrib.auth.backends.ModelBackend']
AUTH_PASSWORD_VALIDATORS '********************'
AUTH_USER_MODEL 'auth.User'
BASE_DIR '/home/protwis/gpcrdb_test'
BUILD_CACHE_DIR '/home/protwis/gpcrdb_data/cache'
CACHES {'alignments': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test_alignment', 'OPTIONS': {'MAX_ENTRIES': 1000}}, 'default': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test/', 'OPTIONS': {'MAX_ENTRIES': 10000000}}}
CACHE_MIDDLEWARE_ALIAS 'default'
CACHE_MIDDLEWARE_KEY_PREFIX '********************'
CACHE_MIDDLEWARE_SECONDS 600
CSRF_COOKIE_AGE 31449600
CSRF_COOKIE_DOMAIN None
CSRF_COOKIE_HTTPONLY False
CSRF_COOKIE_NAME 'csrftoken'
CSRF_COOKIE_PATH '/'
CSRF_COOKIE_SAMESITE 'Lax'
CSRF_COOKIE_SECURE False
CSRF_FAILURE_VIEW 'django.views.csrf.csrf_failure'
CSRF_HEADER_NAME 'HTTP_X_CSRFTOKEN'
CSRF_TRUSTED_ORIGINS []
CSRF_USE_SESSIONS False
DATABASES {'default': {'ATOMIC_REQUESTS': False, 'AUTOCOMMIT': True, 'CONN_MAX_AGE': 0, 'ENGINE': 'django.db.backends.postgresql_psycopg2', 'HOST': 'localhost', 'NAME': 'protwis_202107', 'OPTIONS': {}, 'PASSWORD': '********************', 'PORT': '', 'TEST': {'CHARSET': None, 'COLLATION': None, 'MIRROR': None, 'NAME': None}, 'TIME_ZONE': None, 'USER': 'protwis'}}
DATABASE_ROUTERS []
DATA_DIR '/home/protwis/gpcrdb_data'
DATA_UPLOAD_MAX_MEMORY_SIZE 2621440
DATA_UPLOAD_MAX_NUMBER_FIELDS 1000
DATETIME_FORMAT 'N j, Y, P'
DATETIME_INPUT_FORMATS ['%Y-%m-%d %H:%M:%S', '%Y-%m-%d %H:%M:%S.%f', '%Y-%m-%d %H:%M', '%Y-%m-%d', '%m/%d/%Y %H:%M:%S', '%m/%d/%Y %H:%M:%S.%f', '%m/%d/%Y %H:%M', '%m/%d/%Y', '%m/%d/%y %H:%M:%S', '%m/%d/%y %H:%M:%S.%f', '%m/%d/%y %H:%M', '%m/%d/%y']
DATE_FORMAT 'N j, Y'
DATE_INPUT_FORMATS ['%Y-%m-%d', '%m/%d/%Y', '%m/%d/%y', '%b %d %Y', '%b %d, %Y', '%d %b %Y', '%d %b, %Y', '%B %d %Y', '%B %d, %Y', '%d %B %Y', '%d %B, %Y']
DEBUG True
DEBUG_PROPAGATE_EXCEPTIONS False
DEBUG_TOOLBAR_PATCH_SETTINGS False
DECIMAL_SEPARATOR '.'
DEFAULT_CHARSET 'utf-8'
DEFAULT_CONTENT_TYPE 'text/html'
DEFAULT_EXCEPTION_REPORTER_FILTER 'django.views.debug.SafeExceptionReporterFilter'
DEFAULT_FILE_STORAGE 'django.core.files.storage.FileSystemStorage'
DEFAULT_FROM_EMAIL 'webmaster@localhost'
DEFAULT_INDEX_TABLESPACE ''
DEFAULT_NUMBERING_SCHEME 'gpcrdb'
DEFAULT_PROTEIN_STATE 'inactive'
DEFAULT_SITE 'gpcr'
DEFAULT_TABLESPACE ''
DISALLOWED_USER_AGENTS []
DOCUMENTATION_URL 'https://docs.gpcrdb.org/'
EMAIL_BACKEND 'django.core.mail.backends.smtp.EmailBackend'
EMAIL_HOST 'localhost'
EMAIL_HOST_PASSWORD '********************'
EMAIL_HOST_USER ''
EMAIL_PORT 25
EMAIL_SSL_CERTFILE None
EMAIL_SSL_KEYFILE '********************'
EMAIL_SUBJECT_PREFIX '[Django] '
EMAIL_TIMEOUT None
EMAIL_USE_LOCALTIME False
EMAIL_USE_SSL False
EMAIL_USE_TLS False
FILE_CHARSET 'utf-8'
FILE_UPLOAD_DIRECTORY_PERMISSIONS None
FILE_UPLOAD_HANDLERS ['django.core.files.uploadhandler.MemoryFileUploadHandler', 'django.core.files.uploadhandler.TemporaryFileUploadHandler']
FILE_UPLOAD_MAX_MEMORY_SIZE 2621440
FILE_UPLOAD_PERMISSIONS None
FILE_UPLOAD_TEMP_DIR None
FIRST_DAY_OF_WEEK 0
FIXTURE_DIRS []
FORCE_SCRIPT_NAME None
FORMAT_MODULE_PATH None
FORM_RENDERER 'django.forms.renderers.DjangoTemplates'
GOOGLE_ANALYTICS_API '********************'
GOOGLE_ANALYTICS_KEY '********************'
IGNORABLE_404_URLS []
INSTALLED_APPS ('django.contrib.admin', 'django.contrib.auth', 'django.contrib.contenttypes', 'django.contrib.sessions', 'django.contrib.messages', 'django.contrib.staticfiles', 'django.contrib.humanize', 'debug_toolbar', 'rest_framework', 'rest_framework_swagger', 'polymorphic', 'common', 'api', 'news', 'pages', 'home', 'protein', 'family', 'residue', 'alignment', 'similaritysearch', 'similaritymatrix', 'structure', 'ligand', 'interaction', 'mutation', 'phylogenetic_trees', 'sitesearch', 'build_gpcr', 'construct', 'tools', 'drugs', 'signprot', 'signprot2', 'mutational_landscape', 'contactnetwork', 'seqsign', 'angles', 'hotspots')
INTERNAL_IPS '10.0.2.2'
LANGUAGES [('af', 'Afrikaans'), ('ar', 'Arabic'), ('ast', 'Asturian'), ('az', 'Azerbaijani'), ('bg', 'Bulgarian'), ('be', 'Belarusian'), ('bn', 'Bengali'), ('br', 'Breton'), ('bs', 'Bosnian'), ('ca', 'Catalan'), ('cs', 'Czech'), ('cy', 'Welsh'), ('da', 'Danish'), ('de', 'German'), ('dsb', 'Lower Sorbian'), ('el', 'Greek'), ('en', 'English'), ('en-au', 'Australian English'), ('en-gb', 'British English'), ('eo', 'Esperanto'), ('es', 'Spanish'), ('es-ar', 'Argentinian Spanish'), ('es-co', 'Colombian Spanish'), ('es-mx', 'Mexican Spanish'), ('es-ni', 'Nicaraguan Spanish'), ('es-ve', 'Venezuelan Spanish'), ('et', 'Estonian'), ('eu', 'Basque'), ('fa', 'Persian'), ('fi', 'Finnish'), ('fr', 'French'), ('fy', 'Frisian'), ('ga', 'Irish'), ('gd', 'Scottish Gaelic'), ('gl', 'Galician'), ('he', 'Hebrew'), ('hi', 'Hindi'), ('hr', 'Croatian'), ('hsb', 'Upper Sorbian'), ('hu', 'Hungarian'), ('hy', 'Armenian'), ('ia', 'Interlingua'), ('id', 'Indonesian'), ('io', 'Ido'), ('is', 'Icelandic'), ('it', 'Italian'), ('ja', 'Japanese'), ('ka', 'Georgian'), ('kab', 'Kabyle'), ('kk', 'Kazakh'), ('km', 'Khmer'), ('kn', 'Kannada'), ('ko', 'Korean'), ('lb', 'Luxembourgish'), ('lt', 'Lithuanian'), ('lv', 'Latvian'), ('mk', 'Macedonian'), ('ml', 'Malayalam'), ('mn', 'Mongolian'), ('mr', 'Marathi'), ('my', 'Burmese'), ('nb', 'Norwegian Bokmål'), ('ne', 'Nepali'), ('nl', 'Dutch'), ('nn', 'Norwegian Nynorsk'), ('os', 'Ossetic'), ('pa', 'Punjabi'), ('pl', 'Polish'), ('pt', 'Portuguese'), ('pt-br', 'Brazilian Portuguese'), ('ro', 'Romanian'), ('ru', 'Russian'), ('sk', 'Slovak'), ('sl', 'Slovenian'), ('sq', 'Albanian'), ('sr', 'Serbian'), ('sr-latn', 'Serbian Latin'), ('sv', 'Swedish'), ('sw', 'Swahili'), ('ta', 'Tamil'), ('te', 'Telugu'), ('th', 'Thai'), ('tr', 'Turkish'), ('tt', 'Tatar'), ('udm', 'Udmurt'), ('uk', 'Ukrainian'), ('ur', 'Urdu'), ('vi', 'Vietnamese'), ('zh-hans', 'Simplified Chinese'), ('zh-hant', 'Traditional Chinese')]
LANGUAGES_BIDI ['he', 'ar', 'fa', 'ur']
LANGUAGE_CODE 'en-us'
LANGUAGE_COOKIE_AGE None
LANGUAGE_COOKIE_DOMAIN None
LANGUAGE_COOKIE_NAME 'django_language'
LANGUAGE_COOKIE_PATH '/'
LOCALE_PATHS []
LOGGING {'disable_existing_loggers': False, 'formatters': {'verbose': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s] %(message)s'}, 'verbose_low': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s]'}}, 'handlers': {'build': {'class': 'logging.FileHandler', 'filename': 'logs/build.log', 'formatter': 'verbose', 'level': 'DEBUG'}, 'django': {'class': 'logging.FileHandler', 'filename': 'logs/django.log', 'formatter': 'verbose', 'level': 'WARNING'}, 'protwis': {'class': 'logging.FileHandler', 'filename': 'logs/protwis.log', 'formatter': 'verbose', 'level': 'DEBUG'}}, 'loggers': {'build': {'handlers': ['build'], 'level': 'DEBUG'}, 'django': {'handlers': ['django'], 'level': 'WARNING', 'propagate': True}, 'protwis': {'handlers': ['protwis'], 'level': 'DEBUG'}}, 'version': 1}
LOGGING_CONFIG 'logging.config.dictConfig'
LOGIN_REDIRECT_URL '/accounts/profile/'
LOGIN_URL '/accounts/login/'
LOGOUT_REDIRECT_URL None
MANAGERS []
MEDIA_ROOT '/protwis/media/protwis'
MEDIA_URL '/media/'
MESSAGE_STORAGE 'django.contrib.messages.storage.fallback.FallbackStorage'
MIDDLEWARE ('common.middleware.stats.StatsMiddleware', 'debug_toolbar.middleware.DebugToolbarMiddleware', 'django.contrib.sessions.middleware.SessionMiddleware', 'django.middleware.common.CommonMiddleware', 'django.middleware.csrf.CsrfViewMiddleware', 'django.contrib.auth.middleware.AuthenticationMiddleware', 'django.contrib.messages.middleware.MessageMiddleware', 'django.middleware.clickjacking.XFrameOptionsMiddleware')
MIGRATION_MODULES {}
MONTH_DAY_FORMAT 'F j'
NUMBER_GROUPING 0
PASSWORD_HASHERS '********************'
PASSWORD_RESET_TIMEOUT_DAYS '********************'
PREPEND_WWW False
REFERENCE_POSITIONS {'D1S1': 'D1S1x50', 'D1S2': 'D1S2x50', 'D1T1': 'D1T1x50', 'D1e1': 'D1e1x50', 'ECL1': '23x50', 'ECL2': '45x50', 'H8': '8x50', 'ICL1': '12x50', 'ICL2': '34x50', 'TM1': '1x50', 'TM2': '2x50', 'TM3': '3x50', 'TM4': '4x50', 'TM5': '5x50', 'TM6': '6x50', 'TM7': '7x50'}
ROOT_URLCONF 'protwis.urls'
SECRET_KEY '********************'
SECURE_BROWSER_XSS_FILTER False
SECURE_CONTENT_TYPE_NOSNIFF False
SECURE_HSTS_INCLUDE_SUBDOMAINS False
SECURE_HSTS_PRELOAD False
SECURE_HSTS_SECONDS 0
SECURE_PROXY_SSL_HEADER None
SECURE_REDIRECT_EXEMPT []
SECURE_SSL_HOST None
SECURE_SSL_REDIRECT False
SERVER_EMAIL 'root@localhost'
SESSION_CACHE_ALIAS 'default'
SESSION_COOKIE_AGE 86400
SESSION_COOKIE_DOMAIN None
SESSION_COOKIE_HTTPONLY True
SESSION_COOKIE_NAME 'sessionid'
SESSION_COOKIE_PATH '/'
SESSION_COOKIE_SAMESITE 'Lax'
SESSION_COOKIE_SECURE False
SESSION_ENGINE 'django.contrib.sessions.backends.db'
SESSION_EXPIRE_AT_BROWSER_CLOSE False
SESSION_FILE_PATH None
SESSION_SAVE_EVERY_REQUEST False
SESSION_SERIALIZER 'django.contrib.sessions.serializers.PickleSerializer'
SETTINGS_MODULE 'protwis.settings'
SHORT_DATETIME_FORMAT 'm/d/Y P'
SHORT_DATE_FORMAT 'm/d/Y'
SIGNING_BACKEND 'django.core.signing.TimestampSigner'
SILENCED_SYSTEM_CHECKS []
SITE_NAME 'gpcr'
SITE_TITLE 'GPCRdb'
STATICFILES_DIRS ('/home/protwis/gpcrdb_test/static',)
STATICFILES_FINDERS ['django.contrib.staticfiles.finders.FileSystemFinder', 'django.contrib.staticfiles.finders.AppDirectoriesFinder']
STATICFILES_STORAGE 'django.contrib.staticfiles.storage.StaticFilesStorage'
STATIC_ROOT '/home/protwis/static_test/'
STATIC_URL '/static/'
SWAGGER_SETTINGS {'USE_SESSION_AUTH': False}
TEMPLATES [{'APP_DIRS': True, 'BACKEND': 'django.template.backends.django.DjangoTemplates', 'DIRS': [], 'OPTIONS': {'context_processors': ['django.contrib.auth.context_processors.auth', 'django.template.context_processors.debug', 'django.template.context_processors.i18n', 'django.template.context_processors.media', 'django.template.context_processors.static', 'django.template.context_processors.tz', 'django.contrib.messages.context_processors.messages', 'protwis.context_processors.current_site', 'protwis.context_processors.canonical_tag', 'protwis.context_processors.documentation_url', 'protwis.context_processors.google_analytics', 'protwis.context_processors.site_title'], 'debug': True}}]
TEST_NON_SERIALIZED_APPS []
TEST_RUNNER 'django.test.runner.DiscoverRunner'
THOUSAND_SEPARATOR ','
TIME_FORMAT 'P'
TIME_INPUT_FORMATS ['%H:%M:%S', '%H:%M:%S.%f', '%H:%M']
TIME_ZONE 'Europe/Copenhagen'
USE_I18N True
USE_L10N True
USE_THOUSAND_SEPARATOR False
USE_TZ True
USE_X_FORWARDED_HOST False
USE_X_FORWARDED_PORT False
WSGI_APPLICATION None
X_FRAME_OPTIONS 'SAMEORIGIN'
YEAR_MONTH_FORMAT 'F Y'

Headers

Request headers

Key Value
Accept text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8
Accept-Encoding br,gzip
Accept-Language en-US,en;q=0.5
Connection close
Host test.gpcrdb.org
User-Agent CCBot/2.0 (https://commoncrawl.org/faq/)
X-Forwarded-For 3.236.207.90
X-Forwarded-Proto https
X-Real-Ip 3.236.207.90

Response headers

Key Value
Content-Length 995576
Content-Type text/html; charset=utf-8
Vary Cookie
X-Frame-Options SAMEORIGIN

WSGI environ

Since the WSGI environ inherits the environment of the server, only a significant subset is shown below.

Key Value
PATH_INFO /mutational_landscape/protein/GRM5_human/
QUERY_STRING
REMOTE_ADDR
REQUEST_METHOD GET
SCRIPT_NAME
SERVER_NAME test.gpcrdb.org
SERVER_PORT 443
SERVER_PROTOCOL HTTP/1.0
SERVER_SOFTWARE gunicorn/19.9.0

Request

View information

View function Arguments Keyword arguments URL name
mutational_landscape.views.render_variants () {'protein': 'GRM5_human'} render

No cookies

No session data

No GET data

No POST data

SQL queries from 1 connection

  •   default 362.34 ms (209 queries including 198 similar and 91 duplicates )
  Query Timeline Time (ms) Action
  +
SELECT ••• "protein"."id", "protein"."parent_id", "protein"."family_id", "protein"."species_id", "protein"."source_id", "protein"."residue_numbering_scheme_id", "protein"."sequence_type_id", "protein"."entry_name", "protein"."accession", "protein"."name", "protein"."sequence" FROM "protein" WHERE "protein"."entry_name" = 'grm5_human'
0.7146579564506748%
 2.59

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(89)
  proteins.append(Protein.objects.get(entry_name=protein.lower()))
  +
SELECT ••• "residue_position_set"."id", "residue_position_set"."name", "residue_position_set"."set_type", "residue_position_set"."protein_group" FROM "residue_position_set" WHERE "residue_position_set"."name" = 'State (micro-)switches'
  3 similar queries.
0.2015465721948639%
 0.73

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_test/mutational_landscape/views.py in render_variants(128)
  micro_switches_rset = ResiduePositionSet.objects.get(name="State (micro-)switches")
  +
SELECT ••• "residue_generic_number_equivalent"."id", "residue_generic_number_equivalent"."default_generic_number_id", "residue_generic_number_equivalent"."scheme_id", "residue_generic_number_equivalent"."label" FROM "residue_generic_number_equivalent" INNER JOIN "residue_position_set_residue_position" ON ("residue_generic_number_equivalent"."id" = "residue_position_set_residue_position"."residuegenericnumberequivalent_id") WHERE "residue_position_set_residue_position"."residuepositionset_id" = 2
  3 similar queries.
0.4563914543726987%
 1.65