Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
155531953 178525 0 None -2 3 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4467290 178525 0 None -2 3 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155563693 182173 0 None 36 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4575422 182173 0 None 36 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
11332190 7696 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
156598973 7696 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 7696 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 7696 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
11332190 7696 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
156598973 7696 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 7696 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 7696 12 None -22 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5088494 221942 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155538662 179196 0 None 2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4476788 179196 0 None 2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5088494 221942 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5082551 221588 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.0c01804
168275711 196996 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 635 11 2 9 6.0 Cc1ccc(-c2nc(=O)s[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc(C(=O)NS(=O)(=O)C4CC4)c(C4CC4)s3)cc2)c1 10.1016/j.bmc.2021.116587
CHEMBL5174724 196996 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 635 11 2 9 6.0 Cc1ccc(-c2nc(=O)s[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc(C(=O)NS(=O)(=O)C4CC4)c(C4CC4)s3)cc2)c1 10.1016/j.bmc.2021.116587
168293038 198902 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 613 10 2 9 5.3 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(=O)(=O)C1CC1 10.1016/j.bmc.2021.116587
CHEMBL5203480 198902 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 613 10 2 9 5.3 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(=O)(=O)C1CC1 10.1016/j.bmc.2021.116587
CHEMBL5077507 221280 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5077507 221280 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5082551 221588 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.0c01804
168291719 198737 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 587 9 2 9 4.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(C)(=O)=O 10.1016/j.bmc.2021.116587
CHEMBL5200919 198737 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 587 9 2 9 4.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)NS(C)(=O)=O 10.1016/j.bmc.2021.116587
168269858 196754 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 642 13 2 8 6.2 CCONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5170854 196754 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 642 13 2 8 6.2 CCONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
168292803 198842 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5202580 198842 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
168292522 198821 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 639 11 2 9 5.9 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5202223 198821 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 639 11 2 9 5.9 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155519637 177201 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448308 177201 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155530073 178271 0 None 10 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4463797 178271 0 None 10 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155519352 177220 3 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 177220 3 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5085505 221749 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5085505 221749 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)O 10.1021/acs.jmedchem.0c01804
CHEMBL5080998 221493 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCc1ccccc1 10.1021/acs.jmedchem.0c01804
CHEMBL5080998 221493 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCc1ccccc1 10.1021/acs.jmedchem.0c01804
CHEMBL5092307 222137 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
168286108 198167 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 510 8 2 7 5.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)O 10.1016/j.bmc.2021.116587
CHEMBL5192437 198167 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 510 8 2 7 5.8 Cc1sc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)nc1C(=O)O 10.1016/j.bmc.2021.116587
168284015 198030 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5190234 198030 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalizationInhibition of human ChemR23 expressed in CAL-1 cells assessed as receptor internalization
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5092307 222137 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155537257 179046 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4474605 179046 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
155548932 180601 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4538515 180601 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
168280867 197542 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 601 10 2 9 5.2 CCS(=O)(=O)NC(=O)c1nc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)sc1C 10.1016/j.bmc.2021.116587
CHEMBL5183095 197542 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 601 10 2 9 5.2 CCS(=O)(=O)NC(=O)c1nc(N(CC2CC2)[C@H](C)c2ccc(-c3cc(Cl)ccc3-c3nc(=O)o[nH]3)cc2)sc1C 10.1016/j.bmc.2021.116587
155544237 180146 0 None 3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4527534 180146 0 None 3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
11936 7775 5 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 10.1016/j.bmc.2021.116587
162679547 7775 5 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 10.1016/j.bmc.2021.116587
CHEMBL5180985 7775 5 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 10.1016/j.bmc.2021.116587
168282236 197742 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 628 12 2 8 5.8 CONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5185986 197742 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilizationAgonist activity at human ChemR23 expressed in CAL-1 assessed as increase in calcium mobilization
ChEMBL 628 12 2 8 5.8 CONC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
155535518 178847 0 None 4 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472121 178847 0 None 4 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5092307 222137 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155535988 178888 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472664 178888 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5082981 221614 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5082981 221614 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting methodAgonist activity at Wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as accumulation of inositol phosphate incubated for 3 hrs by liquid scintillation counting method
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155518713 177059 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4446260 177059 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL5089041 221972 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(N)=O 10.1021/acs.jmedchem.0c01804
CHEMBL5089041 221972 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(N)=O 10.1021/acs.jmedchem.0c01804
CHEMBL5092307 222137 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5088494 221942 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5088494 221942 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
155538284 179178 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4476545 179178 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
155569501 182971 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
CHEMBL4593522 182971 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
11332190 7696 12 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
156598973 7696 12 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 7696 12 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 7696 12 None -22 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
11332190 7696 12 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
156598973 7696 12 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
3422 7696 12 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
CHEMBL5081975 7696 12 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None None 10.1021/acs.jmedchem.0c01804
155554828 181399 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4557657 181399 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentrationAgonist activity at chemR23 expressed in human CAL1 cells assessed as increase in intracellular calcium ion concentration
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL5082981 221614 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
CHEMBL5082981 221614 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assayAgonist activity at wild type CMKL1 (unknown origin) expressed in COS-7 cells assessed as increase in calcium flux measured for 40 sec by Fluo-2 AM dye based assay
ChEMBL None None None C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/acs.jmedchem.0c01804
162649940 186774 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746987 186774 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
162656586 187676 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 530 8 2 7 6.2 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
CHEMBL4757632 187676 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 530 8 2 7 6.2 C[C@H](c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
162674241 189995 0 None - 1 Human 8.0 pIC50 = 8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 518 9 1 8 6.4 CCCCN(c1nc2c(-c3nccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4796012 189995 0 None - 1 Human 8.0 pIC50 = 8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 518 9 1 8 6.4 CCCCN(c1nc2c(-c3nccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162671889 189636 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(F)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4791599 189636 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(F)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
168284015 198030 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5190234 198030 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1666 82 2 31 6.9 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155548932 180601 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4538515 180601 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 10 2 7 4.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)NC)ccc2o1 10.1016/j.bmc.2019.115091
162654876 187368 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 8 2 7 5.5 C[C@H](c1ccc(-c2ccccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
CHEMBL4754349 187368 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 8 2 7 5.5 C[C@H](c1ccc(-c2ccccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
155531953 178525 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4467290 178525 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162655374 187589 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2c(C(=O)NC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4756747 187589 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2c(C(=O)NC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162677428 190275 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4799609 190275 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155531953 178525 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4467290 178525 0 None -2 3 Human 7.0 pIC50 = 7.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
168292803 198842 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5202580 198842 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 931 32 2 14 6.7 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155519637 177201 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448308 177201 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 509 10 2 7 5.3 CCCCN(c1nc2cc(CC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155519969 177143 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 492 8 1 6 6.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(Cl)c2o1 10.1016/j.bmc.2019.115091
CHEMBL4447627 177143 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 492 8 1 6 6.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(Cl)c2o1 10.1016/j.bmc.2019.115091
162649290 186940 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 509 9 1 7 5.7 CCCCN(c1nc2c(C(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4748968 186940 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 509 9 1 7 5.7 CCCCN(c1nc2c(C(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162663355 188689 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 517 9 1 7 7.0 CCCCN(c1nc2c(-c3cccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4779379 188689 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 517 9 1 7 7.0 CCCCN(c1nc2c(-c3cccn3C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162654668 186706 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(-c3nnn[nH]3)cccc2C(F)(F)F)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746196 186706 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(-c3nnn[nH]3)cccc2C(F)(F)F)cc1 10.1016/j.bmc.2020.115622
162654348 187385 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C(F)(F)F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4754530 187385 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 506 8 1 6 7.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C(F)(F)F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162648650 186673 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 531 10 2 8 5.4 CCCCN(c1nc2c(NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4745883 186673 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 531 10 2 8 5.4 CCCCN(c1nc2c(NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162660049 188139 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 559 10 2 9 4.7 CCCCN(c1nc2c(C(=O)NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4763169 188139 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 559 10 2 9 4.7 CCCCN(c1nc2c(C(=O)NS(C)(=O)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
168282945 197537 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1681 55 6 25 8.6 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCn2nnc3c2-c2ccccc2N(C(=O)CCNC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]4NC(=O)N[C@@H]42)Cc2ccccc2-3)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
CHEMBL5183004 197537 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1681 55 6 25 8.6 C[C@H](c1ccc(-c2cc(Cl)ccc2C(=O)NCCOCCOCCOCCOCCOCCOCCn2nnc3c2-c2ccccc2N(C(=O)CCNC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]4NC(=O)N[C@@H]42)Cc2ccccc2-3)cc1)N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(C2CC2)s1 10.1016/j.bmc.2021.116587
155519352 177220 3 None 1 2 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 177220 3 None 1 2 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155531953 178525 0 None 2 3 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4467290 178525 0 None 2 3 Mouse 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162659559 188070 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(F)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4762253 188070 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(F)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162671930 189683 3 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 9 2 7 5.7 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4792296 189683 3 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 9 2 7 5.7 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162673878 189767 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 514 8 2 7 5.7 C[C@H](c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
CHEMBL4793378 189767 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 514 8 2 7 5.7 C[C@H](c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1)N(CC1CC1)c1nc2c(C(=O)O)cccc2o1 10.1016/j.bmc.2020.115622
162673026 189847 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 516 9 2 7 6.0 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4794289 189847 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 516 9 2 7 6.0 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
162657219 187649 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(C)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4757393 187649 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2c(C)cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155538662 179196 0 None -2 2 Mouse 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4476788 179196 0 None -2 2 Mouse 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162654669 186707 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(C)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746197 186707 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(C)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162649970 186838 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2c(NC(C)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4747813 186838 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2c(NC(C)=O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155569501 182971 0 None -1 2 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
CHEMBL4593522 182971 0 None -1 2 Human 5.7 pIC50 = 5.7 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 450 7 1 6 5.9 c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 10.1016/j.bmc.2019.115091
162653266 187181 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 2 7 5.5 CCCCN(c1nc2c(CO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4752027 187181 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 2 7 5.5 CCCCN(c1nc2c(CO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155543662 179987 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 10 1 8 5.2 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4522836 179987 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 10 1 8 5.2 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(CC(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
155530073 178271 0 None 10 2 Human 6.6 pIC50 = 6.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4463797 178271 0 None 10 2 Human 6.6 pIC50 = 6.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155537257 179046 0 None 2 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4474605 179046 0 None 2 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 5.8 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 10.1016/j.bmc.2019.115091
155567133 182658 0 None 1 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(C)c2o1 10.1016/j.bmc.2019.115091
CHEMBL4586253 182658 0 None 1 2 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(C)c2o1 10.1016/j.bmc.2019.115091
162671660 189661 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 539 11 2 8 5.1 CCCCN(c1nc2c(C(=O)N(C)CCO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4791896 189661 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 539 11 2 8 5.1 CCCCN(c1nc2c(C(=O)N(C)CCO)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162661813 188235 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 453 8 2 7 5.6 CCCCN(c1nc2c(N)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4764426 188235 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 453 8 2 7 5.6 CCCCN(c1nc2c(N)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155526368 177924 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 459 7 1 7 5.3 c1ccc(CN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2nc3ccccc3o2)nc1 10.1016/j.bmc.2019.115091
CHEMBL4458521 177924 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 459 7 1 7 5.3 c1ccc(CN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2nc3ccccc3o2)nc1 10.1016/j.bmc.2019.115091
162662697 188769 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 10 1 7 6.2 CCCCN(c1nc2c(COC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4780439 188769 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 482 10 1 7 6.2 CCCCN(c1nc2c(COC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162641724 189036 5 None - 1 Human 8.5 pIC50 = 8.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
CHEMBL4783675 189036 5 None - 1 Human 8.5 pIC50 = 8.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
162652190 187124 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccncc3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4751327 187124 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 515 9 1 7 7.1 CCCCN(c1nc2c(-c3ccncc3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162670503 189745 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(OC)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4793031 189745 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(OC)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155554828 181399 0 None -1 2 Mouse 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4557657 181399 0 None -1 2 Mouse 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162654920 187344 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2c(NC(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4754029 187344 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2c(NC(=O)N(C)C)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155535988 178888 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472664 178888 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 9 2 7 6.1 CCCCN(c1nc2cc(NC(=O)N(C)C)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162674418 190028 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 504 9 1 8 6.2 CCCCN(c1nc2c(-n3cccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4796399 190028 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 504 9 1 8 6.2 CCCCN(c1nc2c(-n3cccn3)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155518713 177059 0 None 2 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4446260 177059 0 None 2 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 424 8 1 6 5.5 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
155538284 179178 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4476545 179178 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 9 1 6 5.9 CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
155550367 181069 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)c(C)cc2o1 10.1016/j.bmc.2019.115091
CHEMBL4549880 181069 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 472 8 1 6 6.4 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)c(C)cc2o1 10.1016/j.bmc.2019.115091
155554828 181399 0 None 1 2 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4557657 181399 0 None 1 2 Human 7.5 pIC50 = 7.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 510 9 3 7 5.8 CCCCN(c1nc2cc(NC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162649458 186842 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 9 2 7 6.3 CCCCN(c1nc2c(C(C)(C)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4747865 186842 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 496 9 2 7 6.3 CCCCN(c1nc2c(C(C)(C)O)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155550204 180630 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 426 8 1 7 4.3 COCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4539132 180630 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 426 8 1 7 4.3 COCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 10.1016/j.bmc.2019.115091
162645029 186242 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(Cl)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4740735 186242 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cccc(Cl)c2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155544237 180146 0 None 3 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4527534 180146 0 None 3 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155519352 177220 3 None -1 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 177220 3 None -1 2 Human 7.4 pIC50 = 7.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
168276231 197201 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 626 12 2 7 6.3 CCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5177967 197201 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 626 12 2 7 6.3 CCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
155564611 182304 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 482 9 1 8 5.3 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
CHEMBL4578235 182304 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 482 9 1 8 5.3 CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C(=O)OC)ccc2o1 10.1016/j.bmc.2019.115091
155538662 179196 0 None 2 2 Human 6.4 pIC50 = 6.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4476788 179196 0 None 2 2 Human 6.4 pIC50 = 6.4 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 495 9 2 7 6.0 CCCCN(c1nc2cc(NC(C)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155563693 182173 0 None 36 2 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4575422 182173 0 None 36 2 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155544237 180146 0 None -3 2 Mouse 6.3 pIC50 = 6.3 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4527534 180146 0 None -3 2 Mouse 6.3 pIC50 = 6.3 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 496 9 3 7 5.5 CCCCN(c1nc2cc(NC(N)=O)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
168286341 198470 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 682 16 2 7 7.9 CCCCCCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
CHEMBL5196772 198470 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 682 16 2 7 7.9 CCCCCCNC(=O)c1ccc(Cl)cc1-c1ccc([C@@H](C)N(CC2CC2)c2nc(C(=O)NS(=O)(=O)C3CC3)c(C3CC3)s2)cc1 10.1016/j.bmc.2021.116587
162668192 189209 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4786002 189209 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 452 8 1 6 6.4 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(C)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162653225 187180 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(F)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4752019 187180 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccc(F)cc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162647018 186314 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 523 10 1 7 6.1 CCCCN(c1nc2c(C(=O)N(C)CC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4741497 186314 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 523 10 1 7 6.1 CCCCN(c1nc2c(C(=O)N(C)CC)cccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162672104 189637 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4791613 189637 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 472 8 1 6 6.7 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
162648558 186686 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746011 186686 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 456 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(F)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
155525712 177854 0 None 1 2 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4457246 177854 0 None 1 2 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 438 8 1 6 6.0 CCCCN(c1nc2ccccc2o1)[C@@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155516007 176810 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)C(C)(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4442745 176810 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 8 1 6 6.2 CCCCN(c1nc2ccccc2o1)C(C)(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162675068 190054 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(OC)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4796678 190054 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysisInhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by human chemerin addition by FDSS6000 analysis
ChEMBL 468 9 1 7 6.1 CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2cc(OC)ccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2020.115622
168294228 199003 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1263 36 3 18 8.8 CCNC(=O)CCC(=O)N1Cc2ccccc2-c2nnn(CCOCCOCCOCCOCCOCCOCCNC(=O)c3ccc(Cl)cc3-c3ccc([C@@H](C)N(CC4CC4)c4nc(C(=O)NS(=O)(=O)C5CC5)c(C5CC5)s4)cc3)c2-c2ccccc21 10.1016/j.bmc.2021.116587
CHEMBL5204898 199003 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signalingInhibition of human ChemR23 expressed in CAL-1 cells assessed as reduction in chemerin-induced calcium signaling
ChEMBL 1263 36 3 18 8.8 CCNC(=O)CCC(=O)N1Cc2ccccc2-c2nnn(CCOCCOCCOCCOCCOCCOCCNC(=O)c3ccc(Cl)cc3-c3ccc([C@@H](C)N(CC4CC4)c4nc(C(=O)NS(=O)(=O)C5CC5)c(C5CC5)s4)cc3)c2-c2ccccc21 10.1016/j.bmc.2021.116587
155563693 182173 0 None -36 2 Mouse 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4575422 182173 0 None -36 2 Mouse 5.1 pIC50 = 5.1 Functional
Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 524 10 3 7 5.5 CCCCN(c1nc2cc(CNC(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
155535518 178847 0 None 4 2 Human 6.0 pIC50 = 6.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4472121 178847 0 None 4 2 Human 6.0 pIC50 = 6.0 Functional
Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin additionInhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced intracellular calcium ion concentration preincubated for 45 mins followed by chemerin addition
ChEMBL 452 9 1 6 6.4 CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
2945 7695 0 None -14 2 Human 8.0 pEC50 = 8.0 Functional
In a β-arrestin recruitment assay.In a β-arrestin recruitment assay.
Guide to Pharmacology None None None None 25437209
2945 7695 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14530373
2945 7695 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
2945 7695 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
2945 7695 0 None -14 2 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23396314
1518 7156 2 None 85 3 Human 6.4 pIC50 = 6.4 Functional
Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.
Guide to Pharmacology 242 4 0 1 3.1 O=C(c1cccc2c1cccc2)CC[N+](C)(C)C 25437209
9781 7156 2 None 85 3 Human 6.4 pIC50 = 6.4 Functional
Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.
Guide to Pharmacology 242 4 0 1 3.1 O=C(c1cccc2c1cccc2)CC[N+](C)(C)C 25437209
CHEMBL1358898 7156 2 None 85 3 Human 6.4 pIC50 = 6.4 Functional
Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.Antagonism of chemerin-stimulated β-arrestin 2 recruitment to CMKLR1 in a cellular assay.
Guide to Pharmacology 242 4 0 1 3.1 O=C(c1cccc2c1cccc2)CC[N+](C)(C)C 25437209
12979 10212 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Determined in h<i>CMKLR1</i>-transfected CHO cells, measuring antagonism of agonist-induced intracellular calcium mobilisationDetermined in h<i>CMKLR1</i>-transfected CHO cells, measuring antagonism of agonist-induced intracellular calcium mobilisation
Guide to Pharmacology 570 9 2 5 7.9 C[C@@H](CC(O)=O)C1=CC=C(OCC2=CC3=C(C(=NN3C4CCCC4)C5=CC(Cl)=C(CO)C(Cl)=C5)C(F)=C2)C=C1 37883692
169422750 10212 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Determined in h<i>CMKLR1</i>-transfected CHO cells, measuring antagonism of agonist-induced intracellular calcium mobilisationDetermined in h<i>CMKLR1</i>-transfected CHO cells, measuring antagonism of agonist-induced intracellular calcium mobilisation
Guide to Pharmacology 570 9 2 5 7.9 C[C@@H](CC(O)=O)C1=CC=C(OCC2=CC3=C(C(=NN3C4CCCC4)C5=CC(Cl)=C(CO)C(Cl)=C5)C(F)=C2)C=C1 37883692
12980 9069 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 442 8 1 5 5.6 CC(C)N1N=C(C2=C1C=C(COC3=CC=C(C=C3)[C@H](C)C(=O)C(O)=O)C=C2)C4=CC=CC=C4 37883692
169422751 9069 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 442 8 1 5 5.6 CC(C)N1N=C(C2=C1C=C(COC3=CC=C(C=C3)[C@H](C)C(=O)C(O)=O)C=C2)C4=CC=CC=C4 37883692
11936 7775 5 None - 1 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 35063894
162679547 7775 5 None - 1 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 35063894
CHEMBL5180985 7775 5 None - 1 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 11 2 9 5.5 C[C@@H](N(CC1CC1)c1nc(C(=O)NS(=O)(=O)C2CC2)c(s1)C1CC1)c1ccc(cc1)c1cc(C)ccc1c1nc(=O)o[nH]1 35063894


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
162649940 186774 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
CHEMBL4746987 186774 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 532 9 2 7 6.6 CCCCN(c1nc2c(C(=O)O)cccc2o1)[C@H](C)c1ccc(-c2cc(Cl)ccc2-c2nc(=O)o[nH]2)cc1 10.1016/j.bmc.2020.115622
155519352 177220 3 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
CHEMBL4448632 177220 3 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 495 9 2 7 5.4 CCCCN(c1nc2cc(C(=O)NC)ccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2019.115091
162641724 189036 5 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
CHEMBL4783675 189036 5 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assayInhibition of chemR23 expressed in human CAL1 cells assessed as reduction in chemerin-induced chemotaxis incubated for 4 hrs by cell counting based CellTiter-Glo assay
ChEMBL 510 8 2 7 5.8 Cc1ccc(-c2nc(=O)o[nH]2)c(-c2ccc([C@@H](C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1 10.1016/j.bmc.2020.115622
9784 10559 0 None - 0 Human 8.3 pIC50 ~ 8.3 Binding
Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.
Guide to Pharmacology None None None None 14530373
9784 10559 0 None - 0 Human 8.3 pIC50 ~ 8.3 Binding
Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.Binding affinity in a radioligand displacement assay using membranes prepared from chemerinR-expressing CHO-K1 cells and <sup>125</sup>I-YHSFFFPGQFAFS as tracer.
Guide to Pharmacology None None None None 24659779
11332190 7696 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
11332190 7696 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
156598973 7696 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
156598973 7696 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
3422 7696 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
3422 7696 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
CHEMBL5081975 7696 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14701797
CHEMBL5081975 7696 12 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312
10473088 10092 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
10473088 10092 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
10473088 10092 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
3333 10092 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
3333 10092 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
3333 10092 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
CHEMBL1742483 10092 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
CHEMBL1742483 10092 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
CHEMBL1742483 10092 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
DB13105 10092 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 15753205
DB13105 10092 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 17339491
DB13105 10092 0 None - 1 Human 8.0 pKd = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 13 4 4 2.9 CC[C@H](/C=C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O)O 20887750
2945 7695 0 None 1 2 Human 8.3 pKd = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18165312