Biased ligand counts

Physiology-bias and pathway-bias is explained in the article Community Guidelines for GPCR Ligand Bias.
This page shows the number of physiology-biased ligands with a bias factor ≥ 5.

Class
(Family)		 A (Rhodopsin) B1 (Secretin) B2 (Adhesion) C (Glutamate) F (Frizzled) T2 (Taste 2)
Total
No. biased ligands 350 4 0 0 0 0 131
No. GPCRs with ligand 240 15 0 0 0 0 240


Biased ligand coverage by GPCR class


Classes: 
Sort by:  
Color by:
Receptor names:


Receptor names:

Inner circle colors indicate a number of ligands:
< 10
< 20
< 30
30+

Transducers
○ Gαs ○ Gαi/o ○ Gαq/11 ○ Gα12/13 ○ β-Arrestin
Primary transducer frequency (from low to high)



Class A
(Rhodopsin)




Class A
Orphans

Class B1
(Secretin)

Class B2
(Adhesion)




Class C
(Glutamate)

Class F
(Frizzled)

Class T
(Taste 2)


Biased ligand counts

Physiology-bias and pathway-bias is explained in the article Community Guidelines for GPCR Ligand Bias.
This page shows the number of pathway-biased ligands with a bias factor ≥ 5.

Class
(Family)		 A (Rhodopsin) B1 (Secretin) B2 (Adhesion) C (Glutamate) F (Frizzled) T2 (Taste 2)
Total
No. biased ligands 131 0 0 0 0 0 131
No. GPCRs with ligand 240 0 0 0 0 0 240


Biased ligand coverage by GPCR class


Classes: 
Sort by:  
Color by:
Receptor names:





Receptor names:

Inner circle colors indicate a number of ligands:
< 10
< 20
< 30
30+

Transducers
○ Gαs ○ Gαi/o ○ Gαq/11 ○ Gα12/13 ○ β-Arrestin
Primary transducer frequency (from low to high)



Class A
(Rhodopsin)




Class A
Orphans

Class B1
(Secretin)

Class B2
(Adhesion)




Class C
(Glutamate)

Class F
(Frizzled)

Class T
(Taste 2)