Receptor | Source | Ligand | No. supporting datasets | Selectivity | Family rank orders | % of 1' G protein family | Quantitative values | % of 1' G protein subtype | Quantitative values | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Uniprot
|
GtoPdb (IUPHAR) |
GPCRdb | Rec. family | Cl | Other protein |
Lab | Biosensor | Down- stream steps |
#Gprots tested |
Ref | Name | Phys. / Surr. |
Gs | Gi/o | Gq/11 | G12/13 | Primary family |
#Fam | Gs | Gi/o | Gq/11 | G12/13 | Gs | Gi/o | Gq/11 | G12/13 | Parameter | Gs | Gi/o | Gq/11 | G12/13 | Primary subtype |
GsL | GsS | Golf | Gi1 | Gi2 | Gi3 | Ggust | Gz | GoA | GoB | Gq | G11 | G14 | G15 | G12 | G13 | Parameter | GsL | GsS | Golf | Gi1 | Gi2 | Gi3 | Ggust | Gz | GoA | GoB | Gq | G11 | G14 | G15 | G12 | G13 | |
5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | - | Bouvier | GEMTA | 3 | 12 | 5-hydroxytryptamine | Phys | - | 3 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 81 | 0 | log(Emax/EC50) | 0.0 | 8.3 | 6.7 | 0.0 | GoB | 0 | - | - | 92 | 85 | - | - | 96 | 97 | 100 | 0 | 0 | 65 | 81 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 7.6 | 7.0 | - | - | 7.9 | 8.0 | 8.3 | 0.0 | 0.0 | 5.4 | 6.7 | 0.0 | 0.0 | |||
5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 3 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | Activation rate (s-1) | 0.0 | 7.4 | 0.1 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 7.4 | - | 0.0 | - | - | 0.1 | - | 0.0 | |||
5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 2 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT1A | 5-HT1A | 5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 41 | 0 | - | - | - | - | - | GoB | 0 | - | - | 92 | 85 | - | - | 96 | 98 | 100 | 0 | 0 | 65 | 41 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | - | Bouvier | GEMTA | 3 | 12 | 5-hydroxytryptamine | Phys | - | 3 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 71 | 0 | log(Emax/EC50) | 0.0 | 8.7 | 6.2 | 0.0 | GoB | 0 | - | - | 99 | 98 | - | - | 93 | 98 | 100 | 0 | 0 | 0 | 71 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.6 | 8.6 | - | - | 8.1 | 8.5 | 8.7 | 0.0 | 0.0 | 0.0 | 6.2 | 0.0 | 0.0 | |||
5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 3 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.4 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.4 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 1 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT1B | 5-HT1B | 5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 36 | 0 | - | - | - | - | - | GoB | 0 | - | - | 99 | 98 | - | - | 93 | 99 | 100 | 0 | 0 | 0 | 36 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT1D | 5-HT1D | 5-Hydroxytryptamine | A | - | Bouvier | GEMTA | 3 | 12 | 5-hydroxytryptamine | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 8.6 | 0.0 | 0.0 | Gi1 | 0 | - | - | 100 | 100 | - | - | 43 | 94 | 94 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.6 | 8.6 | - | - | 3.7 | 8.1 | 8.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
5HT1D | 5-HT1D | 5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.2 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
5HT1D | 5-HT1D | 5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
5HT1D | 5-HT1D | 5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 100 | - | - | 43 | 97 | 94 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT1E | 5-HT1E | 5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | Activation rate (s-1) | 0.0 | 0.9 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.9 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
5HT1E | 5-HT1E | 5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT1E | 5-HT1E | 5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT1F | 5-HT1F | 5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.4 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.4 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
5HT1F | 5-HT1F | 5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT1F | 5-HT1F | 5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | - | Bouvier | GEMTA | 3 | 12 | 5-hydroxytryptamine | Phys | - | 3 | 5 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 77 | 100 | 0 | log(Emax/EC50) | 0.0 | 6.7 | 8.6 | 0.0 | G14 | 0 | - | - | 68 | 63 | - | - | 77 | 62 | 66 | 98 | 99 | 100 | 93 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 5.9 | 5.5 | - | - | 6.7 | 5.4 | 5.7 | 8.4 | 8.5 | 8.6 | 8.0 | 0.0 | 0.0 | |||
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | - | Lambert | RGB-GDP | 0 | 6 | - | 5-hydroxytryptamine | Phys | - | 3 | 5 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Efficacy | 0.00 | 0.00 | 0.01 | 0.00 | Gq | 0 | - | - | 0 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.01 | - | - | - | 0.00 | - | ||
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | 3 | 5 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 3 | 5 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 12 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.5 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 12 | - | 100 | - | - | 17 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.5 | - | - | 0.1 | - | 0.0 | |||
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | - | Inoue | TGF𝛼 | 5 | 1 | 5-hydroxytryptamine | Phys | - | 3 | 5 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.2 | - | - | - | - | - | |||
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 5 | - | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT2A | 5-HT2A | 5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 5 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 22 | 75 | 0 | - | - | - | - | - | G14 | 0 | - | - | 23 | 63 | - | - | 77 | 37 | 66 | 74 | 99 | 100 | 55 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | - | Bouvier | GEMTA | 3 | 12 | 5-hydroxytryptamine | Phys | - | 1 | 4 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 99 | 100 | 0 | log(Emax/EC50) | 0.0 | 7.7 | 7.8 | 0.0 | Gq | 0 | - | - | 0 | 0 | - | - | 99 | 0 | 85 | 100 | 100 | 97 | 90 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 0.0 | 0.0 | - | - | 7.7 | 0.0 | 6.6 | 7.8 | 7.8 | 7.5 | 7.0 | 0.0 | 0.0 | |||
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 1 | 4 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.0 | 0.1 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.0 | - | 0.1 | - | - | 0.0 | - | 0.0 | |||
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | - | Inoue | TGF𝛼 | 5 | 1 | 5-hydroxytryptamine | Phys | - | 1 | 4 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.6 | - | - | - | - | - | |||
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 4 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT2B | 5-HT2B | 5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 4 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 50 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | 0 | 0 | - | - | 99 | 0 | 85 | 100 | 100 | 97 | 45 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | - | Bouvier | GEMTA | 3 | 12 | 5-hydroxytryptamine | Phys | - | 3 | 4 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 97 | 84 | log(Emax/EC50) | 0.0 | 8.7 | 8.4 | 7.3 | Gz | 0 | - | - | 79 | 77 | - | - | 100 | 78 | 84 | 0 | 0 | 0 | 97 | 84 | 84 | log(Emax/EC50) | 0.0 | - | - | 6.9 | 6.7 | - | - | 8.7 | 6.8 | 7.3 | 0.0 | 0.0 | 0.0 | 8.4 | 7.3 | 7.3 | |||
5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 3 | 4 | 1 | Gq/11 | 2 | nc | 2' | 1' | 3' | 0 | 1 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 10.3 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 1 | - | 100 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 10.3 | - | - | 0.1 | - | 0.0 | |||
5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | - | Inoue | TGF𝛼 | 5 | 1 | 5-hydroxytryptamine | Phys | - | 3 | 4 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.4 | - | - | - | - | - | |||
5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 4 | 1 | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT2C | 5-HT2C | 5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 4 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 50 | 98 | 42 | - | - | - | - | - | Gz | 0 | - | - | 79 | 77 | - | - | 100 | 40 | 84 | 50 | 0 | 0 | 49 | 84 | 42 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT4R | 5-HT4 | 5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | 2 | 1 | 1 | 2 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 4 | 9 | 2 | Activation rate (s-1) | 4.2 | 0.2 | 0.4 | 0.1 | GsL | 100 | - | - | - | - | - | - | - | 4 | - | 0 | - | - | 9 | - | 2 | Activation rate (s-1) | 4.2 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.4 | - | 0.1 | |||
5HT4R | 5-HT4 | 5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | 1 | 2 | Gs | 2 | 1' | - | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT4R | 5-HT4 | 5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 1 | 1 | 2 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 4 | 9 | 2 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 4 | - | 0 | - | - | 9 | - | 2 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT5A | 5-HT5A | 5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
5HT5A | 5-HT5A | 5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT5A | 5-HT5A | 5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT6R | 5-HT6 | 5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | 2 | - | 2 | 1 | Gs | 3 | 1' | nc | 2' | 3' | 100 | 0 | 26 | 11 | Activation rate (s-1) | 0.9 | 0.0 | 0.2 | 0.1 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 26 | - | 11 | Activation rate (s-1) | 0.9 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.2 | - | 0.1 | |||
5HT6R | 5-HT6 | 5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | 2 | 1 | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT6R | 5-HT6 | 5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | - | 2 | 1 | Gs | 3 | 1' | nc | 2' | 3' | 100 | 0 | 26 | 11 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 26 | - | 11 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT7R | 5-HT7 | 5-Hydroxytryptamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | 5-hydroxytryptamine | Phys | 3 | 1 | 1 | - | Gs | 2 | 1' | 2' | nc | nc | 100 | 22 | 0 | 0 | Activation rate (s-1) | 0.9 | 0.2 | 0.0 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 22 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.9 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
5HT7R | 5-HT7 | 5-Hydroxytryptamine | A | - | Roth | TRUPATH | 1 | 15 | 5-hydroxytryptamine | Phys | 3 | 1 | 1 | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | log(Emax/EC50) | 100.0 | 0.0 | 0.0 | 0.0 | GsS | 99 | 100 | 99 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | 0 | 0 | 0 | log(Emax/EC50) | 7.8 | 7.9 | 7.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | - | 0.0 | 0.0 | 0.0 | |||
5HT7R | 5-HT7 | 5-Hydroxytryptamine | A | - | Inoue | TGF𝛼 | 5 | 1 | 5-hydroxytryptamine | Phys | 3 | 1 | 1 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.8 | - | - | - | - | - | |||
5HT7R | 5-HT7 | 5-Hydroxytryptamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 1 | 1 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
5HT7R | 5-HT7 | 5-Hydroxytryptamine | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 1 | 1 | - | Gs | 2 | 1' | 2' | nc | nc | 100 | 11 | 0 | 0 | - | - | - | - | - | GsL | 100 | 100 | 99 | 0 | 0 | 0 | 0 | 0 | 11 | 0 | 0 | 0 | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ACM1 | M1 | Acetylcholine (muscarinic) | A | - | Bouvier | GEMTA | 3 | 12 | acetylcholine | Phys | 1 | 2 | 4 | - | Gq/11 | 3 | 2' | 3' | 1' | nc | 75 | 68 | 100 | 0 | log(Emax/EC50) | 5.8 | 5.3 | 7.8 | 0.0 | G11 | 75 | - | - | 64 | 59 | - | - | 68 | 57 | 61 | 97 | 100 | 98 | 99 | 0 | 0 | log(Emax/EC50) | 5.8 | - | - | 4.9 | 4.6 | - | - | 5.3 | 4.4 | 4.8 | 7.5 | 7.8 | 7.6 | 7.6 | 0.0 | 0.0 | |||
ACM1 | M1 | Acetylcholine (muscarinic) | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | acetylcholine | Phys | 1 | 2 | 4 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 5 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 2.4 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 5 | - | 100 | - | - | 55 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 2.4 | - | - | 1.3 | - | 0.0 | |||
ACM1 | M1 | Acetylcholine (muscarinic) | A | - | Inoue | TGF𝛼 | 5 | 1 | acetylcholine | Phys | 1 | 2 | 4 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.5 | - | - | - | - | - | |||
ACM1 | M1 | Acetylcholine (muscarinic) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 2 | 4 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
ACM1 | M1 | Acetylcholine (muscarinic) | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 2 | 4 | - | Gq/11 | 3 | 2' | 3' | 1' | nc | 38 | 36 | 100 | 0 | - | - | - | - | - | G11 | 38 | - | - | 64 | 59 | - | - | 68 | 31 | 61 | 98 | 100 | 98 | 77 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ACM2 | M2 | Acetylcholine (muscarinic) | A | - | Bouvier | GEMTA | 3 | 12 | acetylcholine | Phys | 2 | 3 | 2 | - | Gi/o | 3 | 3' | 1' | 2' | nc | 65 | 100 | 86 | 0 | log(Emax/EC50) | 5.6 | 8.6 | 7.4 | 0.0 | GoB | 65 | - | - | 92 | 88 | - | - | 92 | 94 | 100 | 0 | 0 | 52 | 86 | 0 | 0 | log(Emax/EC50) | 5.6 | - | - | 7.9 | 7.6 | - | - | 8.0 | 8.1 | 8.6 | 0.0 | 0.0 | 4.5 | 7.4 | 0.0 | 0.0 | |||
ACM2 | M2 | Acetylcholine (muscarinic) | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | acetylcholine | Phys | 2 | 3 | 2 | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | Activation rate (s-1) | 0.0 | 1.3 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.3 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
ACM2 | M2 | Acetylcholine (muscarinic) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 2 | 3 | 2 | - | Gi/o | 3 | 2' | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
ACM2 | M2 | Acetylcholine (muscarinic) | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 3 | 2 | - | Gi/o | 3 | 3' | 1' | 2' | nc | 32 | 100 | 44 | 0 | - | - | - | - | - | GoB | 32 | - | - | 92 | 88 | - | - | 92 | 97 | 100 | 0 | 0 | 52 | 44 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
DRD2 | D2 | Dopamine | A | - | Bouvier | GEMTA | 3 | 12 | dopamine | Phys | 1 | 5 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 61 | 0 | log(Emax/EC50) | 0.0 | 8.6 | 5.3 | 0.0 | GoB | 0 | - | - | 93 | 87 | - | - | 86 | 93 | 100 | 0 | 0 | 0 | 61 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.0 | 7.5 | - | - | 7.4 | 8.0 | 8.6 | 0.0 | 0.0 | 0.0 | 5.3 | 0.0 | 0.0 | |||
DRD2 | D2 | Dopamine | A | - | Lambert | RGB-GDP | 0 | 6 | dopamine | Phys | 1 | 5 | 2 | - | Gi/o | 3 | 3' | 1' | 2' | nc | 7 | 100 | 8 | 0 | Efficacy | 0.01 | 0.14 | 0.01 | 0.00 | Gi1 | 7 | - | - | 100 | - | - | - | - | - | - | 8 | - | - | - | 0 | - | Efficacy | 0.01 | - | - | 0.14 | - | - | - | - | - | - | 0.01 | - | - | - | 0.00 | - | |||
DRD2 | D2 | Dopamine | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 5 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.03 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.03 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
DRD2 | D2 | Dopamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | dopamine | Phys | 1 | 5 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 4.2 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 4.2 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
DRD2 | D2 | Dopamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 5 | 2 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
DRD2 | D2 | Dopamine | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 5 | 2 | - | Gi/o | 3 | 3' | 1' | 2' | nc | 2 | 100 | 17 | 0 | - | - | - | - | - | GoB | 2 | - | - | 98 | 87 | - | - | 86 | 96 | 100 | 2 | 0 | 0 | 30 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ACM3 | M3 | Acetylcholine (muscarinic) | A | - | Bouvier | GEMTA | 3 | 12 | acetylcholine | Phys | 1 | 3 | 6 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 72 | 100 | 0 | log(Emax/EC50) | 0.0 | 5.4 | 7.6 | 0.0 | G15 | 0 | - | - | 72 | 65 | - | - | 67 | 67 | 69 | 94 | 97 | 97 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 5.4 | 4.9 | - | - | 5.1 | 5.0 | 5.2 | 7.1 | 7.4 | 7.3 | 7.6 | 0.0 | 0.0 | |||
ACM3 | M3 | Acetylcholine (muscarinic) | A | - | Lambert | RGB-GDP | 0 | 6 | acetylcholine | Phys | 1 | 3 | 6 | - | Gq/11 | 3 | 3' | 2' | 1' | nc | 15 | 67 | 100 | 0 | Efficacy | 0.02 | 0.09 | 0.13 | 0.00 | Gq | 15 | - | - | 67 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Efficacy | 0.02 | - | - | 0.09 | - | - | - | - | - | - | 0.13 | - | - | - | 0.00 | - | |||
ACM3 | M3 | Acetylcholine (muscarinic) | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 3 | 6 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Econstitutive | 0.00 | 0.00 | 0.02 | 0.00 | Gq | 0 | - | - | 0 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.02 | - | - | - | 0.00 | - | |||
ACM3 | M3 | Acetylcholine (muscarinic) | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | acetylcholine | Phys | 1 | 3 | 6 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 13 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.6 | 5.0 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 13 | - | 100 | - | - | 49 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.6 | - | 5.0 | - | - | 2.5 | - | 0.0 | |||
ACM3 | M3 | Acetylcholine (muscarinic) | A | - | Inoue | TGF𝛼 | 5 | 1 | acetylcholine | Phys | 1 | 3 | 6 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.1 | - | - | - | - | - | |||
ACM3 | M3 | Acetylcholine (muscarinic) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 3 | 6 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
ACM3 | M3 | Acetylcholine (muscarinic) | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 6 | - | Gq/11 | 3 | 3' | 2' | 1' | nc | 4 | 38 | 100 | 0 | - | - | - | - | - | Gq | 4 | - | - | 46 | 65 | - | - | 67 | 40 | 69 | 98 | 97 | 97 | 74 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ACM4 | M4 | Acetylcholine (muscarinic) | A | - | Bouvier | GEMTA | 3 | 12 | acetylcholine | Phys | 1 | 5 | 3 | 1 | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 78 | 0 | log(Emax/EC50) | 0.0 | 8.7 | 6.9 | 0.0 | GoB | 0 | - | - | 93 | 94 | - | - | 90 | 92 | 100 | 52 | 0 | 56 | 78 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.1 | 8.2 | - | - | 7.9 | 8.0 | 8.7 | 4.6 | 0.0 | 4.9 | 6.9 | 0.0 | 0.0 | |||
ACM4 | M4 | Acetylcholine (muscarinic) | A | - | Lambert | RGB-GDP | 0 | 6 | acetylcholine | Phys | 1 | 5 | 3 | 1 | Gi/o | 4 | 2' | 1' | 4' | 3' | 16 | 100 | 9 | 11 | Efficacy | 0.06 | 0.39 | 0.04 | 0.04 | Gi1 | 16 | - | - | 100 | - | - | - | - | - | - | 9 | - | - | - | 11 | - | Efficacy | 0.06 | - | - | 0.39 | - | - | - | - | - | - | 0.04 | - | - | - | 0.04 | - | |||
ACM4 | M4 | Acetylcholine (muscarinic) | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 5 | 3 | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.14 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.14 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
ACM4 | M4 | Acetylcholine (muscarinic) | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | acetylcholine | Phys | 1 | 5 | 3 | 1 | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 3 | 0 | Activation rate (s-1) | 0.0 | 5.8 | 0.2 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 3 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 5.8 | - | 0.0 | - | - | 0.2 | - | 0.0 | |||
ACM4 | M4 | Acetylcholine (muscarinic) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 5 | 3 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
ACM4 | M4 | Acetylcholine (muscarinic) | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 5 | 3 | 1 | Gi/o | 4 | 3' | 1' | 2' | 4' | 4 | 100 | 22 | 3 | - | - | - | - | - | GoB | 4 | - | - | 98 | 94 | - | - | 90 | 96 | 100 | 15 | 0 | 56 | 40 | 4 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ACM5 | M5 | Acetylcholine (muscarinic) | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | acetylcholine | Phys | - | 1 | 3 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 6 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.2 | 2.8 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 6 | - | 100 | - | - | 53 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 2.8 | - | - | 1.5 | - | 0.0 | |||
ACM5 | M5 | Acetylcholine (muscarinic) | A | - | Inoue | TGF𝛼 | 5 | 1 | acetylcholine | Phys | - | 1 | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.1 | - | - | - | - | - | |||
ACM5 | M5 | Acetylcholine (muscarinic) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 3 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ACM5 | M5 | Acetylcholine (muscarinic) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 3 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 6 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 6 | - | 100 | - | - | 53 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADA1A | α1A | Adrenoceptors | A | - | Bouvier | GEMTA | 3 | 12 | noradrenaline | Phys | 2 | 1 | 4 | 1 | Gq/11 | 3 | 2' | 3' | 1' | nc | 85 | 78 | 100 | 0 | log(Emax/EC50) | 6.6 | 6.1 | 7.8 | 0.0 | G15 | 85 | - | - | 76 | 0 | - | - | 0 | 78 | 0 | 97 | 97 | 85 | 100 | 0 | 0 | log(Emax/EC50) | 6.6 | - | - | 5.9 | 0.0 | - | - | 0.0 | 6.1 | 0.0 | 7.6 | 7.5 | 6.6 | 7.8 | 0.0 | 0.0 | |||
ADA1A | α1A | Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 2 | 1 | 4 | 1 | Gq/11 | 2 | 2' | nc | 1' | nc | 21 | 0 | 100 | 0 | Activation rate (s-1) | 0.3 | 0.0 | 1.3 | 0.0 | Gq | 21 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 29 | - | 0 | Activation rate (s-1) | 0.3 | - | - | - | - | - | - | - | 0.0 | - | 1.3 | - | - | 0.4 | - | 0.0 | |||
ADA1A | α1A | Adrenoceptors | A | - | Inoue | TGF𝛼 | 5 | 1 | (-)-noradrenaline | Phys | 2 | 1 | 4 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.0 | - | - | - | - | - | |||
ADA1A | α1A | Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | 4 | 1 | Gq/11 | 2 | - | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADA1A | α1A | Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 1 | 4 | 1 | Gq/11 | 3 | 2' | 3' | 1' | nc | 53 | 39 | 100 | 0 | - | - | - | - | - | Gq | 53 | - | - | 76 | 0 | - | - | 0 | 39 | 0 | 98 | 97 | 85 | 64 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADA1B | α1B | Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | - | - | 3 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.0 | 0.5 | 0.0 | G15 | 0 | - | - | - | - | - | - | - | 0 | - | 88 | - | - | 100 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.0 | - | 0.4 | - | - | 0.5 | - | 0.0 | |||
ADA1B | α1B | Adrenoceptors | A | - | Inoue | TGF𝛼 | 5 | 1 | (-)-noradrenaline | Phys | - | - | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.1 | - | - | - | - | - | |||
ADA1B | α1B | Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 3 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADA1B | α1B | Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 3 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | - | - | - | - | - | G15 | 0 | - | - | - | - | - | - | - | 0 | - | 88 | - | - | 100 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADA1D | α1D | Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | - | - | 2 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.0 | 0.2 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 25 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.0 | - | 0.2 | - | - | 0.1 | - | 0.0 | |||
ADA1D | α1D | Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADA1D | α1D | Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 25 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADA2A | α2A | Adrenoceptors | A | - | Bouvier | GEMTA | 3 | 12 | noradrenaline | Phys | 2 | 5 | 1 | 1 | Gi/o | 4 | 4' | 1' | 2' | 3' | 58 | 100 | 68 | 60 | log(Emax/EC50) | 5.3 | 9.1 | 6.2 | 5.5 | Gz | 58 | - | - | 93 | 91 | - | - | 100 | 91 | 96 | 50 | 49 | 49 | 68 | 57 | 60 | log(Emax/EC50) | 5.3 | - | - | 8.5 | 8.3 | - | - | 9.1 | 8.3 | 8.8 | 4.6 | 4.4 | 4.4 | 6.2 | 5.2 | 5.5 | |||
ADA2A | α2A | Adrenoceptors | A | - | Lambert | RGB-GDP | 0 | 6 | noradrenaline | Phys | 2 | 5 | 1 | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.10 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.10 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
ADA2A | α2A | Adrenoceptors | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 2 | 5 | 1 | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.03 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.03 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
ADA2A | α2A | Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 2 | 5 | 1 | 1 | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 10.8 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 10.8 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
ADA2A | α2A | Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 5 | 1 | 1 | Gi/o | 2 | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADA2A | α2A | Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 5 | 1 | 1 | Gi/o | 4 | 4' | 1' | 2' | 3' | 14 | 100 | 17 | 15 | - | - | - | - | - | Gz | 14 | - | - | 98 | 91 | - | - | 100 | 96 | 96 | 12 | 49 | 49 | 34 | 19 | 30 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADA2B | α2B | Adrenoceptors | A | - | Bouvier | GEMTA | 3 | 12 | noradrenaline | Phys | 1 | 3 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 72 | 0 | log(Emax/EC50) | 0.0 | 8.2 | 5.9 | 0.0 | Gz | 0 | - | - | 92 | 87 | - | - | 100 | 93 | 99 | 0 | 0 | 0 | 72 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 7.5 | 7.1 | - | - | 8.2 | 7.6 | 8.1 | 0.0 | 0.0 | 0.0 | 5.9 | 0.0 | 0.0 | |||
ADA2B | α2B | Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 1 | 3 | 1 | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | Activation rate (s-1) | 0.0 | 1.7 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.7 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
ADA2B | α2B | Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 1 | - | Gi/o | 2 | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADA2B | α2B | Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 36 | 0 | - | - | - | - | - | Gz | 0 | - | - | 92 | 87 | - | - | 100 | 96 | 99 | 0 | 0 | 0 | 36 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADA2C | α2C | Adrenoceptors | A | - | Bouvier | GEMTA | 3 | 12 | noradrenaline | Phys | 1 | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 55 | 55 | log(Emax/EC50) | 0.0 | 9.5 | 5.2 | 5.3 | Gz | 0 | - | - | 90 | 88 | - | - | 100 | 93 | 98 | 0 | 0 | 0 | 55 | 0 | 55 | log(Emax/EC50) | 0.0 | - | - | 8.5 | 8.4 | - | - | 9.5 | 8.9 | 9.4 | 0.0 | 0.0 | 0.0 | 5.2 | 0.0 | 5.3 | |||
ADA2C | α2C | Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 1 | 3 | 1 | 1 | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 9.1 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 9.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
ADA2C | α2C | Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 1 | 1 | Gi/o | 2 | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADA2C | α2C | Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 28 | 28 | - | - | - | - | - | Gz | 0 | - | - | 90 | 88 | - | - | 100 | 96 | 98 | 0 | 0 | 0 | 28 | 0 | 28 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADRB1 | β1 | Adrenoceptors | A | - | Bouvier | GEMTA | 3 | 12 | noradrenaline | Phys | 3 | 3 | 2 | 1 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 64 | 85 | 57 | log(Emax/EC50) | 9.6 | 6.1 | 8.2 | 5.5 | GsL | 100 | - | - | 0 | 0 | - | - | 64 | 56 | 60 | 48 | 0 | 56 | 85 | 57 | 54 | log(Emax/EC50) | 9.6 | - | - | 0.0 | 0.0 | - | - | 6.1 | 5.4 | 5.8 | 4.6 | 0.0 | 5.4 | 8.2 | 5.5 | 5.2 | |||
ADRB1 | β1 | Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 3 | 3 | 2 | 1 | Gs | 3 | 1' | 3' | 2' | nc | 100 | 6 | 34 | 0 | Activation rate (s-1) | 2.9 | 0.2 | 1.0 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 6 | - | 0 | - | - | 34 | - | 0 | Activation rate (s-1) | 2.9 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 1.0 | - | 0.0 | |||
ADRB1 | β1 | Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 3 | 2 | 1 | Gs | 2 | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADRB1 | β1 | Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 3 | 2 | 1 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 35 | 60 | 28 | - | - | - | - | - | GsL | 100 | - | - | 0 | 0 | - | - | 64 | 31 | 60 | 24 | 0 | 56 | 60 | 57 | 27 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADRB2 | β2 | Adrenoceptors | A | - | Bouvier | GEMTA | 3 | 12 | noradrenaline | Phys | 6 | 3 | 4 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 77 | 0 | log(Emax/EC50) | 8.2 | 0.0 | 6.3 | 0.0 | GsL | 100 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 0 | 0 | 0 | 77 | 0 | 0 | log(Emax/EC50) | 8.2 | - | - | 0.0 | 0.0 | - | - | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.3 | 0.0 | 0.0 | |||
ADRB2 | β2 | Adrenoceptors | A | - | Lambert | RGB-GDP | 0 | 6 | noradrenaline | Phys | 6 | 3 | 4 | - | Gs | 3 | 1' | 2' | 3' | nc | 100 | 56 | 25 | 0 | Efficacy | 0.09 | 0.05 | 0.02 | 0.00 | GsL | 100 | - | - | 56 | - | - | - | - | - | - | 25 | - | - | - | 0 | - | Efficacy | 0.09 | - | - | 0.05 | - | - | - | - | - | - | 0.02 | - | - | - | 0.00 | - | |||
ADRB2 | β2 | Adrenoceptors | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 6 | 3 | 4 | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | Econstitutive | 0.02 | 0.00 | 0.00 | 0.00 | GsL | 100 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.02 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
ADRB2 | β2 | Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 6 | 3 | 4 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 11 | 0 | Activation rate (s-1) | 2.1 | 0.0 | 0.2 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 11 | - | 0 | Activation rate (s-1) | 2.1 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.2 | - | 0.0 | |||
ADRB2 | β2 | Adrenoceptors | A | - | Roth | TRUPATH | 1 | 15 | (-)-adrenaline | Phys | 6 | 3 | 4 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 8 | 11 | 0 | log(Emax/EC50) | 79.8 | 6.6 | 8.5 | 0.0 | G15 | 80 | 76 | 80 | 0 | 78 | 0 | 0 | 64 | 64 | 70 | 0 | 0 | - | 100 | 0 | 0 | log(Emax/EC50) | 6.8 | 6.4 | 6.8 | 0.0 | 6.6 | 0.0 | 0.0 | 5.4 | 5.4 | 6.0 | 0.0 | 0.0 | - | 8.5 | 0.0 | 0.0 | |||
ADRB2 | β2 | Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 6 | 3 | 4 | - | Gs | 2 | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADRB2 | β2 | Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 6 | 3 | 4 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 13 | 25 | 0 | - | - | - | - | - | GsL | 96 | 76 | 80 | 14 | 39 | 0 | 0 | 32 | 21 | 35 | 5 | 0 | 0 | 63 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADRB3 | β3 | Adrenoceptors | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | (±)-adrenaline | Phys | 2 | 1 | 1 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 18 | 0 | Activation rate (s-1) | 0.5 | 0.0 | 0.1 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 18 | - | 0 | Activation rate (s-1) | 0.5 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.1 | - | 0.0 | |||
ADRB3 | β3 | Adrenoceptors | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | 1 | - | Gs | 2 | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ADRB3 | β3 | Adrenoceptors | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 1 | 1 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 18 | 0 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 18 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
DRD1 | D1 | Dopamine | A | - | Bouvier | GEMTA | 3 | 12 | dopamine | Phys | 5 | 2 | 2 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 61 | 86 | 0 | log(Emax/EC50) | 8.6 | 5.3 | 7.4 | 0.0 | GsL | 100 | - | - | 0 | 0 | - | - | 61 | 0 | 56 | 0 | 0 | 0 | 86 | 0 | 0 | log(Emax/EC50) | 8.6 | - | - | 0.0 | 0.0 | - | - | 5.3 | 0.0 | 4.8 | 0.0 | 0.0 | 0.0 | 7.4 | 0.0 | 0.0 | |||
DRD1 | D1 | Dopamine | A | - | Lambert | RGB-GDP | 0 | 6 | dopamine | Phys | 5 | 2 | 2 | - | Gs | 2 | 1' | 2' | nc | nc | 100 | 71 | 0 | 0 | Efficacy | 0.05 | 0.04 | 0.00 | 0.00 | GsL | 100 | - | - | 71 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.05 | - | - | 0.04 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
DRD1 | D1 | Dopamine | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 5 | 2 | 2 | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | Econstitutive | 0.03 | 0.00 | 0.00 | 0.00 | GsL | 100 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.03 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
DRD1 | D1 | Dopamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | dopamine | Phys | 5 | 2 | 2 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 18 | 0 | Activation rate (s-1) | 1.1 | 0.0 | 0.2 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 18 | - | 0 | Activation rate (s-1) | 1.1 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.2 | - | 0.0 | |||
DRD1 | D1 | Dopamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 5 | 2 | 2 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
DRD1 | D1 | Dopamine | A | - | GproteinDb | merged data | - | - | - | - | - | 5 | 2 | 2 | - | Gs | 3 | 1' | 2' | 3' | nc | 100 | 33 | 26 | 0 | - | - | - | - | - | GsL | 100 | - | - | 24 | 0 | - | - | 61 | 0 | 56 | 0 | 0 | 0 | 52 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
DRD3 | D3 | Dopamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | dopamine | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.3 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.3 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
DRD3 | D3 | Dopamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
DRD3 | D3 | Dopamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
DRD4 | D4 | Dopamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | dopamine | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 3.9 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 3.9 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
DRD4 | D4 | Dopamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
DRD4 | D4 | Dopamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
DRD5 | D5 | Dopamine | A | - | Bouvier | GEMTA | 3 | 12 | dopamine | Phys | 4 | 3 | 2 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 70 | 91 | 0 | log(Emax/EC50) | 8.4 | 5.9 | 7.7 | 0.0 | GsL | 100 | - | - | 60 | 55 | - | - | 0 | 0 | 70 | 0 | 0 | 0 | 91 | 0 | 0 | log(Emax/EC50) | 8.4 | - | - | 5.1 | 4.6 | - | - | 0.0 | 0.0 | 5.9 | 0.0 | 0.0 | 0.0 | 7.7 | 0.0 | 0.0 | |||
DRD5 | D5 | Dopamine | A | - | Lambert | RGB-GDP | 0 | 6 | - | dopamine | Phys | 4 | 3 | 2 | - | Gs | 2 | 1' | 2' | nc | nc | 100 | 65 | 0 | 0 | Efficacy | 0.02 | 0.02 | 0.00 | 0.00 | GsL | 100 | - | - | 65 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.02 | - | - | 0.02 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
DRD5 | D5 | Dopamine | A | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | 4 | 3 | 2 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
DRD5 | D5 | Dopamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | dopamine | Phys | 4 | 3 | 2 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 14 | 41 | 0 | Activation rate (s-1) | 1.6 | 0.2 | 0.6 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 14 | - | 0 | - | - | 41 | - | 0 | Activation rate (s-1) | 1.6 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.6 | - | 0.0 | |||
DRD5 | D5 | Dopamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 4 | 3 | 2 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
DRD5 | D5 | Dopamine | A | - | GproteinDb | merged data | - | - | - | - | - | 4 | 3 | 2 | - | Gs | 3 | 1' | 2' | 3' | nc | 75 | 37 | 33 | 0 | - | - | - | - | - | GsL | 75 | - | - | 42 | 55 | - | - | 0 | 7 | 70 | 0 | 0 | 0 | 66 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
HRH1 | H1 | Histamine | A | - | Bouvier | GEMTA | 3 | 12 | histamine | Phys | 2 | 3 | 6 | 2 | Gq/11 | 4 | 4' | 2' | 1' | 3' | 68 | 83 | 100 | 71 | log(Emax/EC50) | 5.5 | 6.8 | 8.1 | 5.8 | G15 | 68 | - | - | 79 | 75 | - | - | 83 | 73 | 75 | 92 | 95 | 95 | 100 | 71 | 67 | log(Emax/EC50) | 5.5 | - | - | 6.4 | 6.1 | - | - | 6.8 | 6.0 | 6.1 | 7.5 | 7.7 | 7.8 | 8.1 | 5.8 | 5.5 | |||
HRH1 | H1 | Histamine | A | - | Lambert | RGB-GDP | 0 | 6 | histamine | Phys | 2 | 3 | 6 | 2 | Gq/11 | 3 | 3' | 2' | 1' | nc | 28 | 96 | 100 | 0 | Efficacy | 0.02 | 0.07 | 0.08 | 0.00 | Gq | 28 | - | - | 96 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Efficacy | 0.02 | - | - | 0.07 | - | - | - | - | - | - | 0.08 | - | - | - | 0.00 | - | |||
HRH1 | H1 | Histamine | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 2 | 3 | 6 | 2 | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Econstitutive | 0.00 | 0.00 | 0.01 | 0.00 | Gq | 0 | - | - | 0 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.01 | - | - | - | 0.00 | - | |||
HRH1 | H1 | Histamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | histamine | Phys | 2 | 3 | 6 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 30 | 100 | 12 | Activation rate (s-1) | 0.0 | 0.4 | 1.3 | 0.1 | Gq | 0 | - | - | - | - | - | - | - | 30 | - | 100 | - | - | 46 | - | 12 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.4 | - | 1.3 | - | - | 0.6 | - | 0.1 | |||
HRH1 | H1 | Histamine | A | - | Inoue | TGF𝛼 | 5 | 1 | histamine | Phys | 2 | 3 | 6 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.2 | - | - | - | - | - | |||
HRH1 | H1 | Histamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 3 | 6 | 2 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
HRH1 | H1 | Histamine | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 3 | 6 | 2 | Gq/11 | 4 | 3' | 2' | 1' | 4' | 24 | 52 | 100 | 21 | - | - | - | - | - | Gq | 24 | - | - | 58 | 75 | - | - | 83 | 52 | 75 | 98 | 95 | 95 | 73 | 24 | 40 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
HRH2 | H2 | Histamine | A | - | Bouvier | GEMTA | 3 | 12 | histamine | Phys | 5 | 2 | 4 | 1 | Gs | 4 | 1' | 4' | 2' | 3' | 100 | 58 | 93 | 63 | log(Emax/EC50) | 7.0 | 4.1 | 6.5 | 4.4 | GsL | 100 | - | - | 0 | 0 | - | - | 46 | 58 | 58 | 0 | 0 | 0 | 93 | 58 | 63 | log(Emax/EC50) | 7.0 | - | - | 0.0 | 0.0 | - | - | 3.2 | 4.0 | 4.1 | 0.0 | 0.0 | 0.0 | 6.5 | 4.0 | 4.4 | |||
HRH2 | H2 | Histamine | A | - | Lambert | RGB-GDP | 0 | 6 | amthamine | Surr | 5 | 2 | 4 | 1 | Gs | 3 | 1' | 2' | 3' | nc | 100 | 24 | 20 | 0 | Efficacy | 0.08 | 0.02 | 0.02 | 0.00 | GsL | 100 | - | - | 24 | - | - | - | - | - | - | 20 | - | - | - | 0 | - | Efficacy | 0.08 | - | - | 0.02 | - | - | - | - | - | - | 0.02 | - | - | - | 0.00 | - | |||
HRH2 | H2 | Histamine | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 5 | 2 | 4 | 1 | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | Econstitutive | 0.07 | 0.00 | 0.00 | 0.00 | GsL | 100 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.07 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
HRH2 | H2 | Histamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | histamine | Phys | 5 | 2 | 4 | 1 | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 33 | 0 | Activation rate (s-1) | 1.6 | 0.0 | 0.5 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 33 | - | 0 | Activation rate (s-1) | 1.6 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.5 | - | 0.0 | |||
HRH2 | H2 | Histamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 5 | 2 | 4 | 1 | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
HRH2 | H2 | Histamine | A | - | GproteinDb | merged data | - | - | - | - | - | 5 | 2 | 4 | 1 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 20 | 36 | 16 | - | - | - | - | - | GsL | 100 | - | - | 8 | 0 | - | - | 46 | 29 | 58 | 5 | 0 | 0 | 63 | 19 | 32 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
HRH3 | H3 | Histamine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | histamine | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 2.3 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 2.3 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
HRH3 | H3 | Histamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
HRH3 | H3 | Histamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
HRH4 | H4 | Histamine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
HRH4 | H4 | Histamine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
TAAR1 | TA1 | Trace amine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | 1 | - | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
TAAR1 | TA1 | Trace amine | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGTR1 | AT1 | Angiotensin | A | - | Bouvier | GEMTA | 3 | 12 | angiotensin II | Phys | - | 3 | 4 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 79 | 100 | 96 | log(Emax/EC50) | 0.0 | 7.1 | 9.0 | 8.6 | G11 | 0 | - | - | 77 | 76 | - | - | 71 | 79 | 77 | 97 | 100 | 91 | 92 | 93 | 96 | log(Emax/EC50) | 0.0 | - | - | 6.9 | 6.8 | - | - | 6.4 | 7.1 | 6.9 | 8.7 | 9.0 | 8.2 | 8.2 | 8.3 | 8.6 | |||
AGTR1 | AT1 | Angiotensin | A | - | Lambert | RGB-GDP | 0 | 6 | angiotensin II | Phys | - | 3 | 4 | 1 | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 58 | 100 | 0 | Efficacy | 0.00 | 0.03 | 0.05 | 0.00 | Gq | 0 | - | - | 58 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.03 | - | - | - | - | - | - | 0.05 | - | - | - | 0.00 | - | |||
AGTR1 | AT1 | Angiotensin | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 3 | 4 | 1 | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
AGTR1 | AT1 | Angiotensin | A | - | Inoue | TGF𝛼 | 5 | 1 | angiotensin II | Phys | - | 3 | 4 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 10.0 | - | - | - | - | - | |||
AGTR1 | AT1 | Angiotensin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 4 | 1 | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGTR1 | AT1 | Angiotensin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 4 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 46 | 67 | 32 | - | - | - | - | - | G11 | 0 | - | - | 45 | 76 | - | - | 71 | 79 | 77 | 66 | 100 | 91 | 92 | 31 | 96 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGTR2 | AT2 | Angiotensin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGTR2 | AT2 | Angiotensin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
APJ | Apelin | Apelin | A | - | Bouvier | GEMTA | 3 | 12 | [Pyr1]apelin-13 | Phys | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 63 | 72 | log(Emax/EC50) | 0.0 | 9.3 | 5.8 | 6.7 | Gi1 | 0 | - | - | 100 | 99 | - | - | 85 | 94 | 96 | 0 | 0 | 0 | 63 | 72 | 64 | log(Emax/EC50) | 0.0 | - | - | 9.3 | 9.2 | - | - | 7.9 | 8.7 | 8.9 | 0.0 | 0.0 | 0.0 | 5.8 | 6.7 | 5.9 | |||
APJ | Apelin | Apelin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | apelin-17 | Phys | - | 3 | 1 | 1 | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 5.8 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 5.8 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
APJ | Apelin | Apelin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
APJ | Apelin | Apelin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 32 | 36 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 99 | - | - | 85 | 97 | 96 | 0 | 0 | 0 | 32 | 72 | 32 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NMBR | BB1 | Bombesin | A | - | Inoue | TGF𝛼 | 5 | 1 | neuromedin B | Phys | - | - | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 10.4 | - | - | - | - | - | |||
NMBR | BB1 | Bombesin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NMBR | BB1 | Bombesin | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRPR | BB2 | Bombesin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | gastrin-releasing peptide | Phys | - | 1 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 2 | 100 | 6 | Activation rate (s-1) | 0.0 | 0.1 | 4.6 | 0.3 | Gq | 0 | - | - | - | - | - | - | - | 2 | - | 100 | - | - | 0 | - | 6 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 4.6 | - | - | 0.0 | - | 0.3 | |||
GRPR | BB2 | Bombesin | A | - | Inoue | TGF𝛼 | 5 | 1 | bombesin | Phys | - | 1 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.9 | - | - | - | - | - | |||
GRPR | BB2 | Bombesin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 3 | 1 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRPR | BB2 | Bombesin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 2 | 100 | 6 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 2 | - | 100 | - | - | 0 | - | 6 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
BRS3 | BB3 | Bombesin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | [125I][D-Tyr6,β-Ala11,Phe13,Nle14]bombesin-(6-14) | Phys | - | - | 2 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.0 | 0.1 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.0 | - | 0.1 | - | - | 0.0 | - | 0.0 | |||
BRS3 | BB3 | Bombesin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
BRS3 | BB3 | Bombesin | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
BKRB1 | B1 | Bradykinin | A | - | Bouvier | GEMTA | 3 | 12 | kallidin | Phys | - | 2 | 3 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 94 | 100 | 0 | log(Emax/EC50) | 0.0 | 6.0 | 6.4 | 0.0 | G15 | 0 | - | - | 88 | 88 | - | - | 85 | 88 | 94 | 95 | 95 | 95 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 5.7 | 5.6 | - | - | 5.5 | 5.6 | 6.0 | 6.1 | 6.1 | 6.1 | 6.4 | 0.0 | 0.0 | |||
BKRB1 | B1 | Bradykinin | A | - | Inoue | TGF𝛼 | 5 | 1 | bradykinin | Phys | - | 2 | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.5 | - | - | - | - | - | |||
BKRB1 | B1 | Bradykinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 3 | - | Gq/11 | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
BKRB1 | B1 | Bradykinin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 94 | 100 | 0 | - | - | - | - | - | G15 | 0 | - | - | 88 | 88 | - | - | 85 | 88 | 94 | 95 | 95 | 95 | 100 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
BKRB2 | B2 | Bradykinin | A | - | Bouvier | GEMTA | 3 | 12 | kallidin | Phys | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 85 | 100 | 98 | log(Emax/EC50) | 0.0 | 8.0 | 9.4 | 9.2 | Gq | 0 | - | - | 83 | 77 | - | - | 85 | 75 | 82 | 100 | 100 | 100 | 93 | 98 | 95 | log(Emax/EC50) | 0.0 | - | - | 7.9 | 7.3 | - | - | 8.0 | 7.0 | 7.7 | 9.4 | 9.4 | 9.4 | 8.7 | 9.2 | 9.0 | |||
BKRB2 | B2 | Bradykinin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | bradykinin | Phys | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 3 | 100 | 8 | Activation rate (s-1) | 0.0 | 0.2 | 4.4 | 0.4 | Gq | 0 | - | - | - | - | - | - | - | 3 | - | 100 | - | - | 4 | - | 8 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 4.4 | - | - | 0.2 | - | 0.4 | |||
BKRB2 | B2 | Bradykinin | A | - | Inoue | TGF𝛼 | 5 | 1 | kallidin | Phys | 1 | 3 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.8 | - | - | - | - | - | |||
BKRB2 | B2 | Bradykinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 3 | 4 | 2 | Gi/o | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
BKRB2 | B2 | Bradykinin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 44 | 100 | 53 | - | - | - | - | - | Gq | 0 | - | - | 83 | 77 | - | - | 85 | 39 | 82 | 100 | 100 | 100 | 48 | 98 | 52 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCKAR | CCK1 | Cholecystokinin | A | - | Bouvier | GEMTA | 3 | 12 | CCK-8 | Phys | 3 | 2 | 4 | 2 | G12/13 | 4 | 4' | 3' | 2' | 1' | 83 | 88 | 99 | 100 | log(Emax/EC50) | 8.1 | 8.5 | 9.7 | 9.7 | G12 | 83 | - | - | 87 | 84 | - | - | 80 | 88 | 87 | 96 | 98 | 99 | 90 | 100 | 94 | log(Emax/EC50) | 8.1 | - | - | 8.4 | 8.2 | - | - | 7.8 | 8.5 | 8.5 | 9.4 | 9.6 | 9.7 | 8.8 | 9.7 | 9.2 | |||
CCKAR | CCK1 | Cholecystokinin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | CCK-8 | Phys | 3 | 2 | 4 | 2 | Gq/11 | 4 | 4' | 2' | 1' | 3' | 5 | 78 | 100 | 18 | Activation rate (s-1) | 0.2 | 3.2 | 4.1 | 0.7 | Gq | 5 | - | - | - | - | - | - | - | 78 | - | 100 | - | - | 14 | - | 18 | Activation rate (s-1) | 0.2 | - | - | - | - | - | - | - | 3.2 | - | 4.1 | - | - | 0.6 | - | 0.7 | |||
CCKAR | CCK1 | Cholecystokinin | A | - | Inoue | TGF𝛼 | 5 | 1 | CCK-8 | Phys | 3 | 2 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 10.5 | - | - | - | - | - | |||
CCKAR | CCK1 | Cholecystokinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 2 | 4 | 2 | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCKAR | CCK1 | Cholecystokinin | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 2 | 4 | 2 | Gq/11 | 4 | 4' | 2' | 1' | 3' | 44 | 83 | 100 | 59 | - | - | - | - | - | G12 | 44 | - | - | 87 | 84 | - | - | 80 | 83 | 87 | 98 | 98 | 99 | 52 | 100 | 56 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GASR | CCK2 | Cholecystokinin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | CCK-8 | Phys | - | 1 | 3 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 34 | 100 | 12 | Activation rate (s-1) | 0.0 | 1.4 | 4.1 | 0.5 | Gq | 0 | - | - | - | - | - | - | - | 34 | - | 100 | - | - | 29 | - | 12 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.4 | - | 4.1 | - | - | 1.2 | - | 0.5 | |||
GASR | CCK2 | Cholecystokinin | A | - | Inoue | TGF𝛼 | 5 | 1 | CCK-8 | Phys | - | 1 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 10.0 | - | - | - | - | - | |||
GASR | CCK2 | Cholecystokinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 1 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GASR | CCK2 | Cholecystokinin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 3 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 34 | 100 | 12 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 34 | - | 100 | - | - | 29 | - | 12 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
C5AR1 | C5a1 | Complement peptide | A | - | Bouvier | GEMTA | 3 | 12 | C5a | Phys | - | 4 | 2 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 99 | 100 | 0 | log(Emax/EC50) | 0.0 | 9.2 | 9.3 | 0.0 | G15 | 0 | - | - | 98 | 99 | - | - | 88 | 92 | 98 | 0 | 0 | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 9.1 | 9.2 | - | - | 8.1 | 8.5 | 9.1 | 0.0 | 0.0 | 0.0 | 9.3 | 0.0 | 0.0 | |||
C5AR1 | C5a1 | Complement peptide | A | - | Lambert | RGB-GDP | 0 | 6 | - | C5a | Phys | - | 4 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.05 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.05 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
C5AR1 | C5a1 | Complement peptide | A | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | 4 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.03 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.03 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
C5AR1 | C5a1 | Complement peptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 4 | 2 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
C5AR1 | C5a1 | Complement peptide | A | - | GproteinDb | merged data | - | - | - | - | - | - | 4 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 33 | 0 | - | - | - | - | - | G15 | 0 | - | - | 99 | 99 | - | - | 88 | 92 | 98 | 0 | 0 | 0 | 100 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
EDNRA | ETA | Endothelin | A | - | Bouvier | GEMTA | 3 | 12 | endothelin-1 | Phys | 1 | 3 | 5 | 3 | G12/13 | 4 | 4' | 2' | 3' | 1' | 78 | 96 | 93 | 100 | log(Emax/EC50) | 8.1 | 9.9 | 9.6 | 10.3 | G12 | 78 | - | - | 90 | 90 | - | - | 96 | 91 | 93 | 92 | 91 | 93 | 79 | 100 | 92 | log(Emax/EC50) | 8.1 | - | - | 9.3 | 9.3 | - | - | 9.9 | 9.4 | 9.6 | 9.5 | 9.5 | 9.6 | 8.2 | 10.3 | 9.6 | |||
EDNRA | ETA | Endothelin | A | - | Lambert | RGB-GDP | 0 | 6 | endothelin-1 | Phys | 1 | 3 | 5 | 3 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 94 | 36 | Efficacy | 0.00 | 0.06 | 0.06 | 0.02 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 94 | - | - | - | 36 | - | Efficacy | 0.00 | - | - | 0.06 | - | - | - | - | - | - | 0.06 | - | - | - | 0.02 | - | |||
EDNRA | ETA | Endothelin | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 3 | 5 | 3 | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
EDNRA | ETA | Endothelin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | endothelin-2 | Phys | 1 | 3 | 5 | 3 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 40 | 18 | Activation rate (s-1) | 0.0 | 0.5 | 0.2 | 0.1 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 40 | - | - | 0 | - | 18 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.5 | - | 0.2 | - | - | 0.0 | - | 0.1 | |||
EDNRA | ETA | Endothelin | A | - | Inoue | TGF𝛼 | 5 | 1 | endothelin-1 | Phys | 1 | 3 | 5 | 3 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 10.0 | - | - | - | - | - | |||
EDNRA | ETA | Endothelin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 5 | 3 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
EDNRA | ETA | Endothelin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 5 | 3 | Gi/o | 4 | 4' | 1' | 2' | 3' | 20 | 74 | 57 | 38 | - | - | - | - | - | Gz | 20 | - | - | 63 | 90 | - | - | 96 | 96 | 93 | 56 | 91 | 93 | 40 | 45 | 55 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
EDNRB | ETB | Endothelin | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 3 | 4 | 2 | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
EDNRB | ETB | Endothelin | A | - | Lambert | RGB-GDP | 0 | 6 | endothelin-1 | Phys | 1 | 3 | 4 | 2 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 54 | 12 | Efficacy | 0.00 | 0.09 | 0.05 | 0.01 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 54 | - | - | - | 12 | - | Efficacy | 0.00 | - | - | 0.09 | - | - | - | - | - | - | 0.05 | - | - | - | 0.01 | - | |||
EDNRB | ETB | Endothelin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | endothelin-2 | Phys | 1 | 3 | 4 | 2 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 24 | 20 | Activation rate (s-1) | 0.0 | 10.2 | 2.4 | 2.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 24 | - | - | 0 | - | 20 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 10.2 | - | 2.4 | - | - | 0.0 | - | 2.0 | |||
EDNRB | ETB | Endothelin | A | - | Inoue | TGF𝛼 | 5 | 1 | endothelin-1 | Phys | 1 | 3 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.4 | - | - | - | - | - | |||
EDNRB | ETB | Endothelin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 4 | 2 | Gq/11 | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
EDNRB | ETB | Endothelin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 4 | 2 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 67 | 26 | 11 | - | - | - | - | - | GoA | 0 | - | - | 50 | - | - | - | - | 100 | - | 26 | - | - | 0 | 6 | 20 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FPR1 | FPR1 | Formylpeptide | A | - | Lambert | RGB-GDP | 0 | 6 | WKYMVM | Surr | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.12 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.12 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
FPR1 | FPR1 | Formylpeptide | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.07 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.07 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
FPR1 | FPR1 | Formylpeptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FPR1 | FPR1 | Formylpeptide | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FPR2 | FPR2/ALX | Formylpeptide | A | - | Lambert | RGB-GDP | 0 | 6 | WKYMVM | Surr | - | 3 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.09 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.09 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
FPR2 | FPR2/ALX | Formylpeptide | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 3 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.05 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.05 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
FPR2 | FPR2/ALX | Formylpeptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FPR2 | FPR2/ALX | Formylpeptide | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FPR3 | FPR3 | Formylpeptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FPR3 | FPR3 | Formylpeptide | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GALR1 | GAL1 | Galanin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | galanin | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 6.0 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 6.0 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
GALR1 | GAL1 | Galanin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GALR1 | GAL1 | Galanin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GALR2 | GAL2 | Galanin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | galanin | Phys | - | 2 | 3 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 11 | 100 | 17 | Activation rate (s-1) | 0.0 | 0.1 | 1.1 | 0.2 | Gq | 0 | - | - | - | - | - | - | - | 11 | - | 100 | - | - | 7 | - | 17 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 1.1 | - | - | 0.1 | - | 0.2 | |||
GALR2 | GAL2 | Galanin | A | - | Inoue | TGF𝛼 | 5 | 1 | galanin | Phys | - | 2 | 3 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.1 | - | - | - | - | - | |||
GALR2 | GAL2 | Galanin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 3 | 2 | Gq/11 | 3 | - | 2' | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GALR2 | GAL2 | Galanin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 11 | 100 | 17 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 11 | - | 100 | - | - | 7 | - | 17 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GALR3 | GAL3 | Galanin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | galanin | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
GALR3 | GAL3 | Galanin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GALR3 | GAL3 | Galanin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GHSR | Ghrelin | Ghrelin | A | - | Bouvier | GEMTA | 3 | 12 | ghrelin | Phys | - | 2 | 3 | 2 | G12/13 | 3 | nc | 3' | 2' | 1' | 0 | 88 | 90 | 100 | log(Emax/EC50) | 0.0 | 8.2 | 8.3 | 9.3 | G12 | 0 | - | - | 85 | 82 | - | - | 88 | 85 | 88 | 90 | 88 | 89 | 89 | 100 | 90 | log(Emax/EC50) | 0.0 | - | - | 7.9 | 7.7 | - | - | 8.2 | 7.9 | 8.2 | 8.3 | 8.2 | 8.3 | 8.3 | 9.3 | 8.4 | |||
GHSR | Ghrelin | Ghrelin | A | - | Inoue | TGF𝛼 | 5 | 1 | ibutamoren | Surr | - | 2 | 3 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.2 | - | - | - | - | - | |||
GHSR | Ghrelin | Ghrelin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 3 | 2 | Gq/11 | 3 | - | 2' | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GHSR | Ghrelin | Ghrelin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | 2 | G12/13 | 3 | nc | 3' | 2' | 1' | 0 | 88 | 90 | 100 | - | - | - | - | - | G12 | 0 | - | - | 85 | 82 | - | - | 88 | 85 | 88 | 90 | 88 | 89 | 89 | 100 | 90 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GNRHR | GnRH1 | Gonadotrophin-releasing hormone | A | - | Bouvier | GEMTA | 3 | 12 | GnRH I | Phys | - | 1 | 3 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | log(Emax/EC50) | 0.0 | 0.0 | 8.9 | 0.0 | Gq | 0 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 100 | 100 | 92 | 94 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 0.0 | 0.0 | - | - | 0.0 | 0.0 | 0.0 | 8.9 | 8.9 | 8.2 | 8.3 | 0.0 | 0.0 | |||
GNRHR | GnRH1 | Gonadotrophin-releasing hormone | A | - | Inoue | TGF𝛼 | 5 | 1 | leuprolide | Surr | - | 1 | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.1 | - | - | - | - | - | |||
GNRHR | GnRH1 | Gonadotrophin-releasing hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 3 | - | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GNRHR | GnRH1 | Gonadotrophin-releasing hormone | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 3 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 100 | 100 | 92 | 94 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
KISSR | Kisspeptin | Kisspeptin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | kisspeptin-10 | Phys | - | - | 3 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.0 | 1.8 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 29 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.0 | - | 1.8 | - | - | 0.5 | - | 0.0 | |||
KISSR | Kisspeptin | Kisspeptin | A | - | Inoue | TGF𝛼 | 5 | 1 | kisspeptin-10 | Phys | - | - | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.9 | - | - | - | - | - | |||
KISSR | Kisspeptin | Kisspeptin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
KISSR | Kisspeptin | Kisspeptin | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 3 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 0 | - | 100 | - | - | 29 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MCHR1 | MCH1 | Melanin-concentrating hormone | A | - | Inoue | TGF𝛼 | 5 | 1 | melanin-concentrating hormone | Phys | 1 | 1 | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.2 | - | - | - | - | - | |||
MCHR1 | MCH1 | Melanin-concentrating hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | 2 | - | Gi/o | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MCHR1 | MCH1 | Melanin-concentrating hormone | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 2 | - | Gi/o | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MCHR2 | MCH2 | Melanin-concentrating hormone | A | - | Inoue | TGF𝛼 | 5 | 1 | melanin-concentrating hormone | Phys | - | - | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.4 | - | - | - | - | - | |||
MCHR2 | MCH2 | Melanin-concentrating hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
MCHR2 | MCH2 | Melanin-concentrating hormone | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MSHR | MC1 | Melanocortin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | α-MSH | Phys | 2 | - | - | - | Gs | 1 | 1' | nc | 2' | nc | 100 | 0 | 5 | 0 | Activation rate (s-1) | 0.5 | 0.0 | 0.0 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 5 | - | 0 | Activation rate (s-1) | 0.5 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
MSHR | MC1 | Melanocortin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MSHR | MC1 | Melanocortin | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | - | - | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 5 | 0 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 5 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ACTHR | MC2 | Melanocortin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
ACTHR | MC2 | Melanocortin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MC3R | MC3 | Melanocortin | A | - | Bouvier | GEMTA | 3 | 12 | γ-MSH | Phys | 3 | 1 | 3 | 1 | Gq/11 | 4 | 2' | 3' | 1' | 4' | 92 | 75 | 100 | 61 | log(Emax/EC50) | 9.5 | 7.8 | 10.3 | 6.3 | G15 | 92 | - | - | 0 | 0 | - | - | 75 | 0 | 67 | 0 | 0 | 0 | 100 | 61 | 60 | log(Emax/EC50) | 9.5 | - | - | 0.0 | 0.0 | - | - | 7.8 | 0.0 | 6.9 | 0.0 | 0.0 | 0.0 | 10.3 | 6.3 | 6.2 | |||
MC3R | MC3 | Melanocortin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | α-MSH | Phys | 3 | 1 | 3 | 1 | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 94 | 0 | Activation rate (s-1) | 0.1 | 0.0 | 0.1 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 94 | - | 0 | Activation rate (s-1) | 0.1 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.1 | - | 0.0 | |||
MC3R | MC3 | Melanocortin | A | - | Inoue | TGF𝛼 | 5 | 1 | α-MSH | Phys | 3 | 1 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.5 | - | - | - | - | - | |||
MC3R | MC3 | Melanocortin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 1 | 3 | 1 | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MC3R | MC3 | Melanocortin | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 1 | 3 | 1 | Gq/11 | 4 | 2' | 3' | 1' | 4' | 96 | 38 | 97 | 30 | - | - | - | - | - | G15 | 96 | - | - | 0 | 0 | - | - | 75 | 0 | 67 | 0 | 0 | 0 | 97 | 61 | 30 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MC4R | MC4 | Melanocortin | A | - | Bouvier | GEMTA | 3 | 12 | α-MSH | Phys | 3 | 2 | 2 | 1 | Gq/11 | 4 | 2' | 3' | 1' | 4' | 99 | 71 | 100 | 59 | log(Emax/EC50) | 7.9 | 5.7 | 8.1 | 4.7 | G15 | 99 | - | - | 0 | 0 | - | - | 71 | 0 | 0 | 0 | 0 | 0 | 100 | 0 | 59 | log(Emax/EC50) | 7.9 | - | - | 0.0 | 0.0 | - | - | 5.7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 8.1 | 0.0 | 4.7 | |||
MC4R | MC4 | Melanocortin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | α-MSH | Phys | 3 | 2 | 2 | 1 | Gs | 3 | 1' | 2' | 3' | nc | 100 | 43 | 25 | 0 | Activation rate (s-1) | 0.5 | 0.2 | 0.1 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 43 | - | 0 | - | - | 25 | - | 0 | Activation rate (s-1) | 0.5 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.1 | - | 0.0 | |||
MC4R | MC4 | Melanocortin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 2 | 2 | 1 | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MC4R | MC4 | Melanocortin | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 2 | 2 | 1 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 57 | 62 | 30 | - | - | - | - | - | GsL | 100 | - | - | 0 | 0 | - | - | 71 | 22 | 0 | 0 | 0 | 0 | 62 | 0 | 30 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MC5R | MC5 | Melanocortin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | α-MSH | Phys | 2 | - | 1 | - | Gq/11 | 2 | 2' | nc | 1' | nc | 97 | 0 | 100 | 0 | Activation rate (s-1) | 0.1 | 0.0 | 0.2 | 0.0 | G15 | 97 | - | - | - | - | - | - | - | 0 | - | 62 | - | - | 100 | - | 0 | Activation rate (s-1) | 0.1 | - | - | - | - | - | - | - | 0.0 | - | 0.1 | - | - | 0.2 | - | 0.0 | |||
MC5R | MC5 | Melanocortin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | 1 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MC5R | MC5 | Melanocortin | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | - | 1 | - | Gq/11 | 2 | 2' | nc | 1' | nc | 97 | 0 | 100 | 0 | - | - | - | - | - | G15 | 97 | - | - | - | - | - | - | - | 0 | - | 62 | - | - | 100 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MTLR | Motilin | Motilin | A | - | Inoue | TGF𝛼 | 5 | 1 | motilin | Phys | - | - | 2 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.7 | - | - | - | - | - | |||
MTLR | Motilin | Motilin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 2 | 1 | Gq/11 | 2 | - | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MTLR | Motilin | Motilin | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | 1 | Gq/11 | 2 | - | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NMUR1 | NMU1 | Neuromedin U | A | - | Inoue | TGF𝛼 | 5 | 1 | neuromedin U-25 | Phys | - | - | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.6 | - | - | - | - | - | |||
NMUR1 | NMU1 | Neuromedin U | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
NMUR1 | NMU1 | Neuromedin U | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NMUR2 | NMU2 | Neuromedin U | A | - | Inoue | TGF𝛼 | 5 | 1 | neuromedin U-25 | Phys | - | - | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.9 | - | - | - | - | - | |||
NMUR2 | NMU2 | Neuromedin U | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
NMUR2 | NMU2 | Neuromedin U | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPFF1 | NPFF1 | Neuropeptide FF/neuropeptide AF | A | - | Bouvier | GEMTA | 3 | 12 | RFRP-3 | Phys | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 76 | 69 | log(Emax/EC50) | 0.0 | 9.4 | 7.1 | 6.5 | Gz | 0 | - | - | 85 | 83 | - | - | 100 | 88 | 94 | 0 | 0 | 0 | 76 | 65 | 69 | log(Emax/EC50) | 0.0 | - | - | 7.9 | 7.8 | - | - | 9.4 | 8.2 | 8.8 | 0.0 | 0.0 | 0.0 | 7.1 | 6.1 | 6.5 | |||
NPFF1 | NPFF1 | Neuropeptide FF/neuropeptide AF | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neuropeptide FF | Phys | - | 3 | 1 | 1 | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | Activation rate (s-1) | 0.0 | 1.0 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.0 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
NPFF1 | NPFF1 | Neuropeptide FF/neuropeptide AF | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
NPFF1 | NPFF1 | Neuropeptide FF/neuropeptide AF | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 39 | 34 | - | - | - | - | - | Gz | 0 | - | - | 85 | 83 | - | - | 100 | 94 | 94 | 0 | 0 | 0 | 39 | 65 | 34 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPFF2 | NPFF2 | Neuropeptide FF/neuropeptide AF | A | - | Bouvier | GEMTA | 3 | 12 | neuropeptide FF | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 7.7 | 0.0 | 0.0 | Gz | 0 | - | - | 84 | 82 | - | - | 100 | 89 | 97 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 6.5 | 6.3 | - | - | 7.7 | 6.9 | 7.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
NPFF2 | NPFF2 | Neuropeptide FF/neuropeptide AF | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
NPFF2 | NPFF2 | Neuropeptide FF/neuropeptide AF | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gz | 0 | - | - | 84 | 82 | - | - | 100 | 89 | 97 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPSR1 | NPS | Neuropeptide S | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | 1 | - | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPSR1 | NPS | Neuropeptide S | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPBW1 | NPBW1 | Neuropeptide W/neuropeptide B | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
NPBW1 | NPBW1 | Neuropeptide W/neuropeptide B | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPBW2 | NPBW2 | Neuropeptide W/neuropeptide B | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
NPBW2 | NPBW2 | Neuropeptide W/neuropeptide B | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPY1R | Y1 | Neuropeptide Y | A | - | Bouvier | GEMTA | 3 | 12 | neuropeptide Y | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 9.3 | 0.0 | 0.0 | Gz | 0 | - | - | 97 | 94 | - | - | 100 | 89 | 96 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 9.0 | 8.7 | - | - | 9.3 | 8.2 | 8.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
NPY1R | Y1 | Neuropeptide Y | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neuropeptide Y | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.2 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
NPY1R | Y1 | Neuropeptide Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
NPY1R | Y1 | Neuropeptide Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gz | 0 | - | - | 97 | 94 | - | - | 100 | 94 | 96 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR3 | GPR3 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR3 | GPR3 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPY2R | Y2 | Neuropeptide Y | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neuropeptide Y | Phys | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 2.1 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 2.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
NPY2R | Y2 | Neuropeptide Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPY2R | Y2 | Neuropeptide Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPY4R | Y4 | Neuropeptide Y | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neuropeptide Y | Phys | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.5 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.5 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
NPY4R | Y4 | Neuropeptide Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPY4R | Y4 | Neuropeptide Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPY5R | Y5 | Neuropeptide Y | A | - | Bouvier | GEMTA | 3 | 12 | neuropeptide Y | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 6.9 | 0.0 | 0.0 | GoA | 0 | - | - | 0 | 0 | - | - | 92 | 100 | 99 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 0.0 | 0.0 | - | - | 6.4 | 6.9 | 6.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
NPY5R | Y5 | Neuropeptide Y | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neuropeptide Y | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
NPY5R | Y5 | Neuropeptide Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NPY5R | Y5 | Neuropeptide Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | 0 | 0 | - | - | 92 | 100 | 99 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NTR1 | NTS1 | Neurotensin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neurotensin | Phys | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 35 | 100 | 29 | Activation rate (s-1) | 0.0 | 1.4 | 4.2 | 1.2 | Gq | 0 | - | - | - | - | - | - | - | 35 | - | 100 | - | - | 22 | - | 29 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.4 | - | 4.2 | - | - | 0.9 | - | 1.2 | |||
NTR1 | NTS1 | Neurotensin | A | - | Roth | TRUPATH | 1 | 15 | JMV431 | Surr | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 97 | 100 | 97 | log(Emax/EC50) | 0.0 | 9.0 | 9.3 | 9.0 | G11 | 0 | 0 | 0 | 95 | 96 | 92 | 97 | 97 | 97 | 95 | 95 | 100 | - | 98 | 94 | 97 | log(Emax/EC50) | 0.0 | 0.0 | 0.0 | 8.8 | 8.9 | 8.5 | 8.9 | 8.9 | 9.0 | 8.8 | 8.8 | 9.3 | - | 9.1 | 8.7 | 9.0 | |||
NTR1 | NTS1 | Neurotensin | A | - | Inoue | TGF𝛼 | 5 | 1 | neurotensin | Phys | 1 | 3 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.3 | - | - | - | - | - | |||
NTR1 | NTS1 | Neurotensin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 4 | 2 | Gq/11 | 3 | 2' | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NTR1 | NTS1 | Neurotensin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 66 | 100 | 63 | - | - | - | - | - | G11 | 0 | 0 | 0 | 95 | 96 | 92 | 97 | 97 | 66 | 95 | 98 | 100 | - | 60 | 94 | 63 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NTR2 | NTS2 | Neurotensin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
NTR2 | NTS2 | Neurotensin | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OPRD | δ | Opioid | A | - | Bouvier | GEMTA | 3 | 12 | SNC80 | Surr | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 72 | 50 | log(Emax/EC50) | 0.0 | 9.3 | 6.7 | 4.7 | Gz | 0 | - | - | 96 | 92 | - | - | 100 | 95 | 99 | 0 | 0 | 57 | 72 | 0 | 50 | log(Emax/EC50) | 0.0 | - | - | 9.0 | 8.6 | - | - | 9.3 | 8.8 | 9.3 | 0.0 | 0.0 | 5.3 | 6.7 | 0.0 | 4.7 | |||
OPRD | δ | Opioid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | [Leu]enkephalin | Phys | - | 3 | 1 | 1 | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | Activation rate (s-1) | 0.0 | 3.8 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 3.8 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
OPRD | δ | Opioid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OPRD | δ | Opioid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 36 | 25 | - | - | - | - | - | Gz | 0 | - | - | 96 | 92 | - | - | 100 | 98 | 99 | 0 | 0 | 57 | 36 | 0 | 25 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OPRK | κ | Opioid | A | - | Bouvier | GEMTA | 3 | 12 | dynorphin A | Phys | - | 3 | 1 | 2 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 74 | 78 | log(Emax/EC50) | 0.0 | 10.2 | 7.5 | 7.9 | GoB | 0 | - | - | 99 | 96 | - | - | 96 | 96 | 100 | 0 | 0 | 0 | 74 | 78 | 0 | log(Emax/EC50) | 0.0 | - | - | 10.0 | 9.7 | - | - | 9.8 | 9.7 | 10.2 | 0.0 | 0.0 | 0.0 | 7.5 | 7.9 | 0.0 | |||
OPRK | κ | Opioid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | dynorphin A | Phys | - | 3 | 1 | 2 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 4.6 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 4.6 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
OPRK | κ | Opioid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 1 | 2 | Gi/o | 2 | - | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OPRK | κ | Opioid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | 2 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 37 | 39 | - | - | - | - | - | GoB | 0 | - | - | 99 | 96 | - | - | 96 | 98 | 100 | 0 | 0 | 0 | 37 | 78 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OPRM | μ | Opioid | A | - | Bouvier | GEMTA | 3 | 12 | DAMGO | Surr | - | 5 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 64 | 0 | log(Emax/EC50) | 0.0 | 8.9 | 5.7 | 0.0 | Gz | 0 | - | - | 92 | 90 | - | - | 100 | 91 | 96 | 0 | 0 | 0 | 64 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.2 | 8.1 | - | - | 8.9 | 8.1 | 8.6 | 0.0 | 0.0 | 0.0 | 5.7 | 0.0 | 0.0 | |||
OPRM | μ | Opioid | A | - | Lambert | RGB-GDP | 0 | 6 | DAMGO | Surr | - | 5 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.05 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.05 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
OPRM | μ | Opioid | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 5 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.03 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.03 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
OPRM | μ | Opioid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | endomorphin-1 | Phys | - | 5 | 2 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 1.3 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.3 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
OPRM | μ | Opioid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 5 | 2 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OPRM | μ | Opioid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 5 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 16 | 0 | - | - | - | - | - | Gz | 0 | - | - | 97 | 90 | - | - | 100 | 96 | 96 | 0 | 0 | 0 | 32 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OPRX | NOP | Opioid | A | - | Bouvier | GEMTA | 3 | 12 | nociceptin/orphanin FQ | Phys | - | 3 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 84 | 0 | log(Emax/EC50) | 0.0 | 10.8 | 9.1 | 0.0 | Gz | 0 | - | - | 93 | 89 | - | - | 100 | 91 | 96 | 0 | 0 | 69 | 84 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 10.1 | 9.6 | - | - | 10.8 | 9.8 | 10.3 | 0.0 | 0.0 | 7.4 | 9.1 | 0.0 | 0.0 | |||
OPRX | NOP | Opioid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | nociceptin/orphanin FQ | Phys | - | 3 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | Activation rate (s-1) | 0.0 | 4.8 | 0.1 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 4.8 | - | 0.0 | - | - | 0.1 | - | 0.0 | |||
OPRX | NOP | Opioid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 2 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
OPRX | NOP | Opioid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 42 | 0 | - | - | - | - | - | Gz | 0 | - | - | 93 | 89 | - | - | 100 | 96 | 96 | 0 | 0 | 69 | 42 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OX1R | OX1 | Orexin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | orexin-A | Phys | 1 | 2 | 3 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 30 | 100 | 23 | Activation rate (s-1) | 0.0 | 0.2 | 0.7 | 0.2 | Gq | 0 | - | - | - | - | - | - | - | 30 | - | 100 | - | - | 3 | - | 23 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 0.7 | - | - | 0.0 | - | 0.2 | |||
OX1R | OX1 | Orexin | A | - | Inoue | TGF𝛼 | 5 | 1 | orexin-A | Phys | 1 | 2 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.9 | - | - | - | - | - | |||
OX1R | OX1 | Orexin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 2 | 3 | 1 | Gs | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
OX1R | OX1 | Orexin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 2 | 3 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 30 | 100 | 23 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 30 | - | 100 | - | - | 3 | - | 23 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OX2R | OX2 | Orexin | A | - | Bouvier | GEMTA | 3 | 12 | orexin-A | Phys | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 92 | 100 | 73 | log(Emax/EC50) | 0.0 | 8.4 | 9.1 | 6.7 | Gq | 0 | - | - | 74 | 69 | - | - | 92 | 78 | 83 | 100 | 100 | 94 | 79 | 73 | 66 | log(Emax/EC50) | 0.0 | - | - | 6.7 | 6.3 | - | - | 8.4 | 7.1 | 7.6 | 9.1 | 9.1 | 8.6 | 7.2 | 6.7 | 6.0 | |||
OX2R | OX2 | Orexin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | orexin-B | Phys | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 11 | 100 | 7 | Activation rate (s-1) | 0.0 | 0.1 | 0.8 | 0.1 | Gq | 0 | - | - | - | - | - | - | - | 11 | - | 100 | - | - | 0 | - | 7 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.8 | - | - | 0.0 | - | 0.1 | |||
OX2R | OX2 | Orexin | A | - | Inoue | TGF𝛼 | 5 | 1 | orexin-A | Phys | 1 | 3 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.8 | - | - | - | - | - | |||
OX2R | OX2 | Orexin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 3 | 4 | 2 | Gs | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
OX2R | OX2 | Orexin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 4 | 2 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 52 | 100 | 40 | - | - | - | - | - | Gq | 0 | - | - | 74 | 69 | - | - | 92 | 44 | 83 | 100 | 100 | 94 | 40 | 73 | 36 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
QRFPR | QRFP | Peptide P518 | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
QRFPR | QRFP | Peptide P518 | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PRLHR | PrRP | Prolactin-releasing peptide | A | - | Inoue | TGF𝛼 | 5 | 1 | PrRP-20 | Phys | - | - | 1 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.8 | - | - | - | - | - | |||
PAR1 | PAR1 | Proteinase-activated | A | - | Bouvier | GEMTA | 3 | 12 | TFLLR-NH2 | Phys | - | 1 | 2 | 1 | G12/13 | 3 | nc | 3' | 2' | 1' | 0 | 86 | 93 | 100 | log(Emax/EC50) | 0.0 | 5.6 | 6.1 | 6.5 | G13 | 0 | - | - | 58 | 66 | - | - | 86 | 73 | 82 | 93 | 93 | 81 | 87 | 0 | 100 | log(Emax/EC50) | 0.0 | - | - | 3.8 | 4.3 | - | - | 5.6 | 4.8 | 5.4 | 6.1 | 6.1 | 5.3 | 5.7 | 0.0 | 6.5 | |||
PAR1 | PAR1 | Proteinase-activated | A | - | Inoue | TGF𝛼 | 5 | 1 | TFLLR-NH2 | Phys | - | 1 | 2 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.1 | - | - | - | - | - | |||
PAR1 | PAR1 | Proteinase-activated | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 2 | 1 | G12/13 | 3 | nc | 3' | 2' | 1' | 0 | 86 | 93 | 100 | - | - | - | - | - | G13 | 0 | - | - | 58 | 66 | - | - | 86 | 73 | 82 | 93 | 93 | 81 | 87 | 0 | 100 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PAR2 | PAR2 | Proteinase-activated | A | - | Bouvier | GEMTA | 3 | 12 | PAR2 peptide | Phys | - | 1 | 1 | 1 | G12/13 | 3 | nc | 2' | 3' | 1' | 0 | 89 | 86 | 100 | log(Emax/EC50) | 0.0 | 5.9 | 5.6 | 6.6 | G12 | 0 | - | - | 78 | 79 | - | - | 84 | 80 | 89 | 71 | 86 | 77 | 84 | 100 | 97 | log(Emax/EC50) | 0.0 | - | - | 5.1 | 5.2 | - | - | 5.5 | 5.2 | 5.9 | 4.6 | 5.6 | 5.1 | 5.5 | 6.6 | 6.4 | |||
PAR2 | PAR2 | Proteinase-activated | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | 1 | G12/13 | 3 | nc | 2' | 3' | 1' | 0 | 89 | 86 | 100 | - | - | - | - | - | G12 | 0 | - | - | 78 | 79 | - | - | 84 | 80 | 89 | 71 | 86 | 77 | 84 | 100 | 97 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PAR3 | PAR3 | Proteinase-activated | A | - | Inoue | TGF𝛼 | 5 | 1 | thrombin | Phys | - | - | 1 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.2 | - | - | - | - | - | |||
PAR4 | PAR4 | Proteinase-activated | A | - | Inoue | TGF𝛼 | 5 | 1 | thrombin | Phys | - | - | 1 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.4 | - | - | - | - | - | |||
RXFP1 | RXFP1 | Relaxin family peptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 1 | - | - | Gs | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
RXFP1 | RXFP1 | Relaxin family peptide | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | - | - | Gs | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
RXFP2 | RXFP2 | Relaxin family peptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 1 | - | - | Gi/o | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
RXFP2 | RXFP2 | Relaxin family peptide | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | - | - | Gi/o | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
RL3R1 | RXFP3 | Relaxin family peptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
RL3R1 | RXFP3 | Relaxin family peptide | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
RL3R2 | RXFP4 | Relaxin family peptide | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
RL3R2 | RXFP4 | Relaxin family peptide | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SSR1 | SST1 | Somatostatin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | SRIF-14 | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.2 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
SSR1 | SST1 | Somatostatin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SSR1 | SST1 | Somatostatin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SSR2 | SST2 | Somatostatin | A | - | Bouvier | GEMTA | 3 | 12 | SRIF-14 | Phys | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 75 | 67 | log(Emax/EC50) | 0.0 | 10.7 | 8.0 | 7.1 | Gz | 0 | - | - | 96 | 93 | - | - | 100 | 90 | 96 | 62 | 0 | 70 | 75 | 67 | 0 | log(Emax/EC50) | 0.0 | - | - | 10.2 | 10.0 | - | - | 10.7 | 9.6 | 10.2 | 6.6 | 0.0 | 7.5 | 8.0 | 7.1 | 0.0 | |||
SSR2 | SST2 | Somatostatin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | SRIF-14 | Phys | - | 3 | 1 | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 1.8 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.8 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
SSR2 | SST2 | Somatostatin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SSR2 | SST2 | Somatostatin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 38 | 34 | - | - | - | - | - | Gz | 0 | - | - | 96 | 93 | - | - | 100 | 95 | 96 | 31 | 0 | 70 | 38 | 67 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SSR3 | SST3 | Somatostatin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | SRIF-14 | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | Activation rate (s-1) | 0.0 | 2.3 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 2.3 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
SSR3 | SST3 | Somatostatin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SSR3 | SST3 | Somatostatin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SSR4 | SST4 | Somatostatin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | SRIF-14 | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.2 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
SSR4 | SST4 | Somatostatin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SSR4 | SST4 | Somatostatin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SSR5 | SST5 | Somatostatin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | SRIF-14 | Phys | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | Activation rate (s-1) | 0.0 | 4.4 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 4.4 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
SSR5 | SST5 | Somatostatin | A | - | Inoue | TGF𝛼 | 5 | 1 | SRIF-14 | Phys | - | 2 | 1 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.3 | - | - | - | - | - | |||
SSR5 | SST5 | Somatostatin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SSR5 | SST5 | Somatostatin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NK1R | NK1 | Tachykinin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | substance P | Phys | 1 | 1 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 6 | 100 | 48 | Activation rate (s-1) | 0.0 | 0.3 | 4.2 | 2.0 | Gq | 0 | - | - | - | - | - | - | - | 6 | - | 100 | - | - | 4 | - | 48 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.3 | - | 4.2 | - | - | 0.2 | - | 2.0 | |||
NK1R | NK1 | Tachykinin | A | - | Inoue | TGF𝛼 | 5 | 1 | substance P | Phys | 1 | 1 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.5 | - | - | - | - | - | |||
NK1R | NK1 | Tachykinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | 3 | 1 | Gs | 2 | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NK1R | NK1 | Tachykinin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 6 | 100 | 48 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 6 | - | 100 | - | - | 4 | - | 48 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NK2R | NK2 | Tachykinin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neurokinin A | Phys | 1 | 1 | 3 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 29 | 100 | 7 | Activation rate (s-1) | 0.0 | 1.4 | 4.6 | 0.3 | Gq | 0 | - | - | - | - | - | - | - | 29 | - | 100 | - | - | 10 | - | 7 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.4 | - | 4.6 | - | - | 0.5 | - | 0.3 | |||
NK2R | NK2 | Tachykinin | A | - | Inoue | TGF𝛼 | 5 | 1 | neurokinin B | Phys | 1 | 1 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.5 | - | - | - | - | - | |||
NK2R | NK2 | Tachykinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | 3 | 1 | Gs | 2 | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NK2R | NK2 | Tachykinin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 3 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 29 | 100 | 7 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 29 | - | 100 | - | - | 10 | - | 7 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NK3R | NK3 | Tachykinin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | neurokinin B | Phys | - | 1 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 7 | 100 | 67 | Activation rate (s-1) | 0.0 | 0.2 | 2.9 | 1.9 | Gq | 0 | - | - | - | - | - | - | - | 7 | - | 100 | - | - | 15 | - | 67 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 2.9 | - | - | 0.4 | - | 1.9 | |||
NK3R | NK3 | Tachykinin | A | - | Inoue | TGF𝛼 | 5 | 1 | neurokinin A | Phys | - | 1 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.2 | - | - | - | - | - | |||
NK3R | NK3 | Tachykinin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 3 | 1 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
NK3R | NK3 | Tachykinin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 7 | 100 | 67 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 7 | - | 100 | - | - | 15 | - | 67 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR4 | GPR4 | A orphans | A | - | Bouvier | GEMTA | 3 | 12 | pH (proton) | Phys | 3 | 3 | 3 | 2 | Gs | 3 | 1' | 3' | 2' | nc | 100 | 55 | 76 | 0 | log(Emax/EC50) | 7.7 | 4.3 | 5.9 | 0.0 | GsL | 100 | - | - | 55 | 54 | - | - | 0 | 0 | 0 | 76 | 75 | 65 | 72 | 0 | 0 | log(Emax/EC50) | 7.7 | - | - | 4.3 | 4.2 | - | - | 0.0 | 0.0 | 0.0 | 5.9 | 5.8 | 5.0 | 5.6 | 0.0 | 0.0 | |||
GPR4 | GPR4 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 3 | 3 | 3 | 2 | Gs | 4 | 1' | 3' | 4' | 2' | 100 | 59 | 46 | 99 | Econstitutive | 0.03 | 0.02 | 0.02 | 0.03 | GsL | 100 | - | - | 59 | - | - | - | - | - | - | 46 | - | - | 38 | - | 99 | Econstitutive | 0.03 | - | - | 0.02 | - | - | - | - | - | - | 0.02 | - | - | 0.01 | - | 0.03 | |||
GPR4 | GPR4 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 3 | 3 | 2 | Gs | 4 | 1' | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR4 | GPR4 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 3 | 3 | 2 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 57 | 61 | 50 | - | - | - | - | - | GsL | 100 | - | - | 57 | 54 | - | - | 0 | 0 | 0 | 61 | 75 | 65 | 55 | 0 | 50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
TRFR | TRH1 | Thyrotropin-releasing hormone | A | - | Inoue | TGF𝛼 | 5 | 1 | TRH | Phys | - | - | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.6 | - | - | - | - | - | |||
TRFR | TRH1 | Thyrotropin-releasing hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
TRFR | TRH1 | Thyrotropin-releasing hormone | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
UR2R | UT | Urotensin | A | - | Inoue | TGF𝛼 | 5 | 1 | urotensin-II | Phys | - | - | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.2 | - | - | - | - | - | |||
UR2R | UT | Urotensin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
UR2R | UT | Urotensin | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
V1AR | V1A | Vasopressin and oxytocin | A | - | Bouvier | GEMTA | 3 | 12 | vasopressin | Phys | - | 2 | 4 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 80 | 100 | 0 | log(Emax/EC50) | 0.0 | 7.0 | 8.7 | 0.0 | G11 | 0 | - | - | 78 | 77 | - | - | 80 | 79 | 78 | 98 | 100 | 93 | 91 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 6.8 | 6.7 | - | - | 7.0 | 6.9 | 6.8 | 8.5 | 8.7 | 8.1 | 7.9 | 0.0 | 0.0 | |||
V1AR | V1A | Vasopressin and oxytocin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | vasopressin | Phys | - | 2 | 4 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 17 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.7 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 17 | - | 100 | - | - | 8 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.7 | - | - | 0.1 | - | 0.0 | |||
V1AR | V1A | Vasopressin and oxytocin | A | - | Inoue | TGF𝛼 | 5 | 1 | vasopressin | Phys | - | 2 | 4 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 10.1 | - | - | - | - | - | |||
V1AR | V1A | Vasopressin and oxytocin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 4 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
V1AR | V1A | Vasopressin and oxytocin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 4 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 48 | 100 | 0 | - | - | - | - | - | G11 | 0 | - | - | 78 | 77 | - | - | 80 | 48 | 78 | 99 | 100 | 93 | 50 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
V1BR | V1B | Vasopressin and oxytocin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | vasopressin | Phys | - | 1 | 3 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 21 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.6 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 21 | - | 100 | - | - | 9 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.6 | - | - | 0.1 | - | 0.0 | |||
V1BR | V1B | Vasopressin and oxytocin | A | - | Inoue | TGF𝛼 | 5 | 1 | vasopressin | Phys | - | 1 | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.5 | - | - | - | - | - | |||
V1BR | V1B | Vasopressin and oxytocin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
V1BR | V1B | Vasopressin and oxytocin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 3 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 21 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 21 | - | 100 | - | - | 9 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
V2R | V2 | Vasopressin and oxytocin | A | - | Bouvier | GEMTA | 3 | 12 | vasopressin | Phys | 4 | 3 | 4 | 2 | Gs | 4 | 1' | 4' | 2' | 3' | 100 | 60 | 88 | 77 | log(Emax/EC50) | 10.1 | 6.1 | 8.9 | 7.8 | GsL | 100 | - | - | 60 | 51 | - | - | 0 | 55 | 0 | 69 | 70 | 65 | 88 | 0 | 77 | log(Emax/EC50) | 10.1 | - | - | 6.1 | 5.1 | - | - | 0.0 | 5.5 | 0.0 | 6.9 | 7.1 | 6.5 | 8.9 | 0.0 | 7.8 | |||
V2R | V2 | Vasopressin and oxytocin | A | - | Lambert | RGB-GDP | 0 | 6 | vasopressin | Phys | 4 | 3 | 4 | 2 | Gs | 3 | 1' | 2' | 3' | nc | 100 | 42 | 33 | 0 | Efficacy | 0.06 | 0.03 | 0.02 | 0.00 | GsL | 100 | - | - | 42 | - | - | - | - | - | - | 33 | - | - | - | 0 | - | Efficacy | 0.06 | - | - | 0.03 | - | - | - | - | - | - | 0.02 | - | - | - | 0.00 | - | |||
V2R | V2 | Vasopressin and oxytocin | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 4 | 3 | 4 | 2 | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
V2R | V2 | Vasopressin and oxytocin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | vasopressin | Phys | 4 | 3 | 4 | 2 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 6 | 41 | 5 | Activation rate (s-1) | 1.4 | 0.1 | 0.6 | 0.1 | GsL | 100 | - | - | - | - | - | - | - | 6 | - | 11 | - | - | 41 | - | 5 | Activation rate (s-1) | 1.4 | - | - | - | - | - | - | - | 0.1 | - | 0.2 | - | - | 0.6 | - | 0.1 | |||
V2R | V2 | Vasopressin and oxytocin | A | - | Inoue | TGF𝛼 | 5 | 1 | vasopressin | Phys | 4 | 3 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.5 | - | - | - | - | - | |||
V2R | V2 | Vasopressin and oxytocin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 4 | 3 | 4 | 2 | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
V2R | V2 | Vasopressin and oxytocin | A | - | GproteinDb | merged data | - | - | - | - | - | 4 | 3 | 4 | 2 | Gs | 4 | 1' | 3' | 2' | 4' | 75 | 27 | 40 | 20 | - | - | - | - | - | GsL | 75 | - | - | 34 | 51 | - | - | 0 | 30 | 0 | 28 | 70 | 65 | 64 | 0 | 41 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OXYR | OT | Vasopressin and oxytocin | A | - | Bouvier | GEMTA | 3 | 12 | oxytocin | Phys | - | 3 | 5 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | log(Emax/EC50) | 0.0 | 0.0 | 7.6 | 0.0 | Gq | 0 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 100 | 100 | 90 | 96 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 0.0 | 0.0 | - | - | 0.0 | 0.0 | 0.0 | 7.6 | 7.6 | 6.8 | 7.3 | 0.0 | 0.0 | |||
OXYR | OT | Vasopressin and oxytocin | A | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | 3 | 5 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
OXYR | OT | Vasopressin and oxytocin | A | - | Lambert | RGB-GDP | 0 | 6 | - | oxytocin | Phys | - | 3 | 5 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 69 | 100 | 0 | Efficacy | 0.00 | 0.03 | 0.04 | 0.00 | Gq | 0 | - | - | 69 | - | - | - | - | - | - | 100 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.03 | - | - | - | - | - | - | 0.04 | - | - | - | 0.00 | - | ||
OXYR | OT | Vasopressin and oxytocin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | oxytocin | Phys | - | 3 | 5 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 13 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.6 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 13 | - | 100 | - | - | 17 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.6 | - | - | 0.1 | - | 0.0 | |||
OXYR | OT | Vasopressin and oxytocin | A | - | Inoue | TGF𝛼 | 5 | 1 | oxytocin | Phys | - | 3 | 5 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.0 | - | - | - | - | - | |||
OXYR | OT | Vasopressin and oxytocin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 5 | - | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OXYR | OT | Vasopressin and oxytocin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 5 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 20 | 75 | 0 | - | - | - | - | - | G11 | 0 | - | - | 23 | 0 | - | - | 0 | 6 | 0 | 75 | 100 | 90 | 56 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CML1 | Chemerin | Chemerin receptor | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
CML1 | Chemerin | Chemerin receptor | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR1 | CCR1 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR1 | CCR1 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR2 | CCR2 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR2 | CCR2 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR3 | CCR3 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR3 | CCR3 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR4 | CCR4 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR4 | CCR4 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR5 | CCR5 | Chemokine | A | - | Bouvier | GEMTA | 3 | 12 | CCL3 | Phys | - | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 70 | 0 | log(Emax/EC50) | 0.0 | 9.1 | 6.4 | 0.0 | Gz | 0 | - | - | 98 | 96 | - | - | 100 | 94 | 97 | 0 | 0 | 0 | 70 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.9 | 8.7 | - | - | 9.1 | 8.5 | 8.8 | 0.0 | 0.0 | 0.0 | 6.4 | 0.0 | 0.0 | |||
CCR5 | CCR5 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR5 | CCR5 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 70 | 0 | - | - | - | - | - | Gz | 0 | - | - | 98 | 96 | - | - | 100 | 94 | 97 | 0 | 0 | 0 | 70 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR6 | CCR6 | Chemokine | A | - | Bouvier | GEMTA | 3 | 12 | CCL2 | Phys | - | 2 | 1 | 1 | G12/13 | 3 | nc | 2' | 3' | 1' | 0 | 95 | 95 | 100 | log(Emax/EC50) | 0.0 | 8.2 | 8.2 | 8.6 | G12 | 0 | - | - | 86 | 94 | - | - | 95 | 83 | 91 | 0 | 0 | 0 | 95 | 100 | 0 | log(Emax/EC50) | 0.0 | - | - | 7.3 | 8.1 | - | - | 8.2 | 7.1 | 7.8 | 0.0 | 0.0 | 0.0 | 8.2 | 8.6 | 0.0 | |||
CCR6 | CCR6 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 1 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR6 | CCR6 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | 1 | G12/13 | 3 | nc | 2' | 3' | 1' | 0 | 95 | 95 | 100 | - | - | - | - | - | G12 | 0 | - | - | 86 | 94 | - | - | 95 | 83 | 91 | 0 | 0 | 0 | 95 | 100 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR7 | CCR7 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
CCR7 | CCR7 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR8 | CCR8 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR8 | CCR8 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR9 | CCR9 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR9 | CCR9 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR10 | CCR10 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CCR10 | CCR10 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CXCR1 | CXCR1 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
CXCR1 | CXCR1 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CXCR2 | CXCR2 | Chemokine | A | - | Bouvier | GEMTA | 3 | 12 | CXCL8 | Phys | - | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 87 | 0 | log(Emax/EC50) | 0.0 | 9.4 | 8.2 | 0.0 | GoB | 0 | - | - | 99 | 99 | - | - | 91 | 97 | 100 | 0 | 0 | 0 | 87 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 9.4 | 9.3 | - | - | 8.6 | 9.1 | 9.4 | 0.0 | 0.0 | 0.0 | 8.2 | 0.0 | 0.0 | |||
CXCR2 | CXCR2 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
CXCR2 | CXCR2 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 87 | 0 | - | - | - | - | - | GoB | 0 | - | - | 99 | 99 | - | - | 91 | 97 | 100 | 0 | 0 | 0 | 87 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CXCR3 | CXCR3 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CXCR3 | CXCR3 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CXCR4 | CXCR4 | Chemokine | A | - | Bouvier | GEMTA | 3 | 12 | CXCL12α | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 8.5 | 0.0 | 0.0 | Gi2 | 0 | - | - | 97 | 100 | - | - | 88 | 92 | 95 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.3 | 8.5 | - | - | 7.5 | 7.8 | 8.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
CXCR4 | CXCR4 | Chemokine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | CXCL12α | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 7 | 0 | Activation rate (s-1) | 0.0 | 0.3 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 7 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.3 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
CXCR4 | CXCR4 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CXCR4 | CXCR4 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 4 | 0 | - | - | - | - | - | Gi2 | 0 | - | - | 97 | 100 | - | - | 88 | 96 | 95 | 0 | 0 | 0 | 4 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CXCR5 | CXCR5 | Chemokine | A | - | Bouvier | GEMTA | 3 | 12 | CXCL13 | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 8.2 | 0.0 | 0.0 | GoB | 0 | - | - | 95 | 94 | - | - | 99 | 96 | 100 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 7.7 | 7.6 | - | - | 8.1 | 7.8 | 8.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
CXCR5 | CXCR5 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CXCR5 | CXCR5 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoB | 0 | - | - | 95 | 94 | - | - | 99 | 96 | 100 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CXCR6 | CXCR6 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CXCR6 | CXCR6 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CX3C1 | CX3CR1 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CX3C1 | CX3CR1 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
XCR1 | XCR1 | Chemokine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
XCR1 | XCR1 | Chemokine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FSHR | FSH | Glycoprotein hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | 1 | - | Gs | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FSHR | FSH | Glycoprotein hormone | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 1 | - | Gs | 3 | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LSHR | LH | Glycoprotein hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | - | 1 | - | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
LSHR | LH | Glycoprotein hormone | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
TSHR | TSH | Glycoprotein hormone | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | 1 | - | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
TSHR | TSH | Glycoprotein hormone | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PKR1 | PKR1 | Prokineticin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | - | 1 | - | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
PKR1 | PKR1 | Prokineticin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PKR2 | PKR2 | Prokineticin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 1 | 1 | - | Gq/11 | 3 | 2' | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
PKR2 | PKR2 | Prokineticin | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 1 | - | Gq/11 | 3 | 2' | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FFAR1 | FFA1 | Free fatty acid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | 1 | - | Gq/11 | 3 | 2' | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FFAR1 | FFA1 | Free fatty acid | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 1 | - | Gq/11 | 3 | 2' | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FFAR2 | FFA2 | Free fatty acid | A | - | Bouvier | GEMTA | 3 | 12 | propanoic acid | Phys | - | 2 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 95 | 0 | log(Emax/EC50) | 0.0 | 4.3 | 4.1 | 0.0 | Gi1 | 0 | - | - | 100 | 95 | - | - | 0 | 0 | 0 | 87 | 90 | 95 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 4.3 | 4.1 | - | - | 0.0 | 0.0 | 0.0 | 3.7 | 3.9 | 4.1 | 0.0 | 0.0 | 0.0 | |||
FFAR2 | FFA2 | Free fatty acid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 2 | - | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
FFAR2 | FFA2 | Free fatty acid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 2 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 95 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 95 | - | - | 0 | 0 | 0 | 87 | 90 | 95 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FFAR3 | FFA3 | Free fatty acid | A | - | Bouvier | GEMTA | 3 | 12 | propanoic acid | Phys | - | 2 | - | 1 | Gi/o | 2 | nc | 1' | nc | 2' | 0 | 100 | 0 | 86 | log(Emax/EC50) | 0.0 | 5.0 | 0.0 | 4.3 | GoB | 0 | - | - | 98 | 99 | - | - | 89 | 97 | 100 | 0 | 0 | 0 | 0 | 86 | 78 | log(Emax/EC50) | 0.0 | - | - | 4.8 | 4.9 | - | - | 4.4 | 4.8 | 5.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.3 | 3.9 | |||
FFAR3 | FFA3 | Free fatty acid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
FFAR3 | FFA3 | Free fatty acid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | 1 | Gi/o | 2 | nc | 1' | nc | 2' | 0 | 100 | 0 | 86 | - | - | - | - | - | GoB | 0 | - | - | 98 | 99 | - | - | 89 | 97 | 100 | 0 | 0 | 0 | 0 | 86 | 78 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FFAR4 | FFA4 | Free fatty acid | A | - | Bouvier | GEMTA | 3 | 12 | α-linolenic acid | Phys | - | 1 | 2 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 92 | 100 | 78 | log(Emax/EC50) | 0.0 | 4.8 | 5.2 | 4.0 | G15 | 0 | - | - | 91 | 91 | - | - | 0 | 86 | 92 | 84 | 87 | 96 | 100 | 0 | 78 | log(Emax/EC50) | 0.0 | - | - | 4.7 | 4.7 | - | - | 0.0 | 4.4 | 4.8 | 4.4 | 4.5 | 4.9 | 5.2 | 0.0 | 4.0 | |||
FFAR4 | FFA4 | Free fatty acid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 2 | 1 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
FFAR4 | FFA4 | Free fatty acid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 2 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 92 | 100 | 78 | - | - | - | - | - | G15 | 0 | - | - | 91 | 91 | - | - | 0 | 86 | 92 | 84 | 87 | 96 | 100 | 0 | 78 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LT4R1 | BLT1 | Leukotriene | A | - | Bouvier | GEMTA | 3 | 12 | LTB4 | Phys | - | 2 | 3 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 97 | 85 | log(Emax/EC50) | 0.0 | 10.1 | 9.7 | 8.6 | GoB | 0 | - | - | 99 | 99 | - | - | 91 | 95 | 100 | 59 | 53 | 65 | 97 | 85 | 85 | log(Emax/EC50) | 0.0 | - | - | 10.0 | 10.0 | - | - | 9.2 | 9.5 | 10.1 | 5.9 | 5.4 | 6.5 | 9.7 | 8.6 | 8.6 | |||
LT4R1 | BLT1 | Leukotriene | A | - | Inoue | TGF𝛼 | 5 | 1 | LTB4 | Phys | - | 2 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.3 | - | - | - | - | - | |||
LT4R1 | BLT1 | Leukotriene | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 3 | 1 | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
LT4R1 | BLT1 | Leukotriene | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 97 | 85 | - | - | - | - | - | GoB | 0 | - | - | 99 | 99 | - | - | 91 | 95 | 100 | 59 | 53 | 65 | 97 | 85 | 85 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LT4R2 | BLT2 | Leukotriene | A | - | Bouvier | GEMTA | 3 | 12 | LTB4 | Phys | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 8.4 | 0.0 | 0.0 | Gi1 | 0 | - | - | 100 | 98 | - | - | 76 | 92 | 97 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.4 | 8.2 | - | - | 6.4 | 7.8 | 8.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
LT4R2 | BLT2 | Leukotriene | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
LT4R2 | BLT2 | Leukotriene | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 98 | - | - | 76 | 92 | 97 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CLTR1 | CysLT1 | Leukotriene | A | - | Bouvier | GEMTA | 3 | 12 | LTB4 | Phys | - | 2 | 3 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 89 | 0 | log(Emax/EC50) | 0.0 | 8.3 | 7.3 | 0.0 | Gz | 0 | - | - | 98 | 98 | - | - | 100 | 92 | 98 | 85 | 84 | 80 | 89 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.2 | 8.1 | - | - | 8.3 | 7.6 | 8.1 | 7.0 | 6.9 | 6.6 | 7.3 | 0.0 | 0.0 | |||
CLTR1 | CysLT1 | Leukotriene | A | - | Inoue | TGF𝛼 | 5 | 1 | LTD4 | Phys | - | 2 | 3 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 9.0 | - | - | - | - | - | |||
CLTR1 | CysLT1 | Leukotriene | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 3 | - | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
CLTR1 | CysLT1 | Leukotriene | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 89 | 0 | - | - | - | - | - | Gz | 0 | - | - | 98 | 98 | - | - | 100 | 92 | 98 | 85 | 84 | 80 | 89 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CLTR2 | CysLT2 | Leukotriene | A | - | Bouvier | GEMTA | 3 | 12 | LTB4 | Phys | - | 2 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 90 | 100 | 94 | log(Emax/EC50) | 0.0 | 8.4 | 9.3 | 8.8 | G15 | 0 | - | - | 74 | 71 | - | - | 90 | 73 | 80 | 91 | 90 | 94 | 100 | 94 | 87 | log(Emax/EC50) | 0.0 | - | - | 6.9 | 6.6 | - | - | 8.4 | 6.8 | 7.5 | 8.5 | 8.4 | 8.7 | 9.3 | 8.8 | 8.1 | |||
CLTR2 | CysLT2 | Leukotriene | A | - | Inoue | TGF𝛼 | 5 | 1 | LTD4 | Phys | - | 2 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.2 | - | - | - | - | - | |||
CLTR2 | CysLT2 | Leukotriene | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 3 | 1 | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
CLTR2 | CysLT2 | Leukotriene | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | 1 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 90 | 100 | 94 | - | - | - | - | - | G15 | 0 | - | - | 74 | 71 | - | - | 90 | 73 | 80 | 91 | 90 | 94 | 100 | 94 | 87 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OXER1 | OXE | Leukotriene | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
OXER1 | OXE | Leukotriene | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | - | Bouvier | GEMTA | 3 | 12 | 2-oleoyl-LPA | Phys | - | 2 | 3 | 2 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 73 | 93 | log(Emax/EC50) | 0.0 | 8.3 | 6.1 | 7.8 | Gi1 | 0 | - | - | 100 | 0 | - | - | 0 | 95 | 0 | 73 | 66 | 55 | 69 | 0 | 93 | log(Emax/EC50) | 0.0 | - | - | 8.3 | 0.0 | - | - | 0.0 | 7.9 | 0.0 | 6.1 | 5.5 | 4.6 | 5.8 | 0.0 | 7.8 | |||
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | - | Inoue | TGF𝛼 | 5 | 1 | LPA | Phys | - | 2 | 3 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.0 | - | - | - | - | - | |||
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 3 | 2 | Gi/o | 3 | - | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LPAR1 | LPA1 | Lysophospholipid (LPA) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | 2 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 73 | 93 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 0 | - | - | 0 | 95 | 0 | 73 | 66 | 55 | 69 | 0 | 93 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LPAR2 | LPA2 | Lysophospholipid (LPA) | A | - | Bouvier | GEMTA | 3 | 12 | 2-oleoyl-LPA | Phys | - | 2 | 3 | 2 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 81 | 97 | log(Emax/EC50) | 0.0 | 8.5 | 6.9 | 8.2 | GoB | 0 | - | - | 94 | 95 | - | - | 85 | 91 | 100 | 80 | 78 | 81 | 73 | 0 | 97 | log(Emax/EC50) | 0.0 | - | - | 8.0 | 8.0 | - | - | 7.2 | 7.7 | 8.5 | 6.7 | 6.6 | 6.9 | 6.1 | 0.0 | 8.2 | |||
LPAR2 | LPA2 | Lysophospholipid (LPA) | A | - | Inoue | TGF𝛼 | 5 | 1 | LPA | Phys | - | 2 | 3 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.6 | - | - | - | - | - | |||
LPAR2 | LPA2 | Lysophospholipid (LPA) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 3 | 2 | Gi/o | 3 | - | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LPAR2 | LPA2 | Lysophospholipid (LPA) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 3 | 2 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 81 | 97 | - | - | - | - | - | GoB | 0 | - | - | 94 | 95 | - | - | 85 | 91 | 100 | 80 | 78 | 81 | 73 | 0 | 97 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LPAR3 | LPA3 | Lysophospholipid (LPA) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LPAR3 | LPA3 | Lysophospholipid (LPA) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LPAR4 | LPA4 | Lysophospholipid (LPA) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 1 | 1 | 1 | Gs | 4 | 1' | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
LPAR4 | LPA4 | Lysophospholipid (LPA) | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 1 | 1 | Gs | 4 | 1' | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LPAR5 | LPA5 | Lysophospholipid (LPA) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 1 | 1 | Gq/11 | 2 | - | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LPAR5 | LPA5 | Lysophospholipid (LPA) | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | 1 | Gq/11 | 2 | - | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
LPAR6 | LPA6 | Lysophospholipid (LPA) | A | - | Roth | TRUPATH | 1 | 15 | LPA | Phys | 2 | 2 | - | 2 | Gs | 3 | 1' | 3' | nc | 2' | 100 | 9 | 0 | 10 | log(Emax/EC50) | 75.4 | 7.1 | 0.0 | 7.4 | G13 | 0 | 75 | 0 | 78 | 85 | 72 | 87 | 89 | 95 | 96 | 0 | 0 | - | 0 | 98 | 100 | log(Emax/EC50) | 0.0 | 5.6 | 0.0 | 5.7 | 6.2 | 5.3 | 6.4 | 6.6 | 7.0 | 7.1 | 0.0 | 0.0 | - | 0.0 | 7.2 | 7.4 | |||
LPAR6 | LPA6 | Lysophospholipid (LPA) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 2 | 2 | - | 2 | Gs | 3 | 1' | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
LPAR6 | LPA6 | Lysophospholipid (LPA) | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 2 | - | 2 | Gs | 3 | 1' | 3' | nc | 2' | 100 | 9 | 0 | 10 | - | - | - | - | - | G13 | 0 | 75 | 0 | 78 | 85 | 72 | 87 | 89 | 95 | 96 | 0 | 0 | - | 0 | 98 | 100 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | - | Bouvier | GEMTA | 3 | 12 | sphingosine 1-phosphate | Phys | - | 2 | 1 | 1 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 79 | 86 | log(Emax/EC50) | 0.0 | 7.3 | 5.8 | 6.3 | Gi1 | 0 | - | - | 100 | 96 | - | - | 0 | 91 | 95 | 0 | 0 | 0 | 79 | 86 | 86 | log(Emax/EC50) | 0.0 | - | - | 7.3 | 7.0 | - | - | 0.0 | 6.6 | 7.0 | 0.0 | 0.0 | 0.0 | 5.8 | 6.3 | 6.3 | |||
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
S1PR1 | S1P1 | Lysophospholipid (S1P) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | 1 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 79 | 86 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 96 | - | - | 0 | 91 | 95 | 0 | 0 | 0 | 79 | 86 | 86 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
S1PR2 | S1P2 | Lysophospholipid (S1P) | A | - | Inoue | TGF𝛼 | 5 | 1 | sphingosine 1-phosphate | Phys | 1 | - | 2 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.2 | - | - | - | - | - | |||
S1PR2 | S1P2 | Lysophospholipid (S1P) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | 2 | 1 | Gs | 3 | 1' | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
S1PR2 | S1P2 | Lysophospholipid (S1P) | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 2 | 1 | Gs | 3 | 1' | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
S1PR3 | S1P3 | Lysophospholipid (S1P) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 1 | 1 | Gi/o | 3 | - | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
S1PR3 | S1P3 | Lysophospholipid (S1P) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | 1 | Gi/o | 3 | - | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
S1PR4 | S1P4 | Lysophospholipid (S1P) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | 1 | Gi/o | 2 | - | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
S1PR4 | S1P4 | Lysophospholipid (S1P) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | 1 | Gi/o | 2 | - | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
S1PR5 | S1P5 | Lysophospholipid (S1P) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | 1 | Gi/o | 2 | - | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
S1PR5 | S1P5 | Lysophospholipid (S1P) | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | 1 | Gi/o | 2 | - | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CNR1 | CB1 | Cannabinoid | A | - | Bouvier | GEMTA | 3 | 12 | WIN55212-2 | Surr | 3 | 5 | 2 | 3 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 100 | 100 | 91 | log(Emax/EC50) | 0.0 | 7.6 | 7.6 | 6.9 | Gi1 | 0 | - | - | 100 | 93 | - | - | 92 | 97 | 99 | 0 | 0 | 48 | 100 | 91 | 88 | log(Emax/EC50) | 0.0 | - | - | 7.6 | 7.1 | - | - | 7.0 | 7.4 | 7.5 | 0.0 | 0.0 | 3.6 | 7.6 | 6.9 | 6.7 | |||
CNR1 | CB1 | Cannabinoid | A | - | Lambert | RGB-GDP | 0 | 6 | - | CP55940 | Surr | 3 | 5 | 2 | 3 | Gi/o | 4 | 3' | 1' | 4' | 2' | 37 | 100 | 18 | 43 | Efficacy | 0.02 | 0.06 | 0.01 | 0.02 | Gi1 | 37 | - | - | 100 | - | - | - | - | - | - | 18 | - | - | - | 43 | - | Efficacy | 0.02 | - | - | 0.06 | - | - | - | - | - | - | 0.01 | - | - | - | 0.02 | - | ||
CNR1 | CB1 | Cannabinoid | A | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | 3 | 5 | 2 | 3 | Gi/o | 3 | 3' | 1' | nc | 2' | 34 | 100 | 0 | 41 | Econstitutive | 0.02 | 0.06 | 0.00 | 0.02 | Gi1 | 34 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 41 | - | Econstitutive | 0.02 | - | - | 0.06 | - | - | - | - | - | - | 0.00 | - | - | - | 0.02 | - | ||
CNR1 | CB1 | Cannabinoid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | anandamide | Phys | 3 | 5 | 2 | 3 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
CNR1 | CB1 | Cannabinoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 5 | 2 | 3 | Gi/o | 2 | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CNR1 | CB1 | Cannabinoid | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 5 | 2 | 3 | Gi/o | 4 | 4' | 1' | 3' | 2' | 18 | 100 | 30 | 44 | - | - | - | - | - | Gi1 | 18 | - | - | 100 | 93 | - | - | 92 | 98 | 99 | 4 | 0 | 48 | 50 | 58 | 44 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CNR2 | CB2 | Cannabinoid | A | - | Bouvier | GEMTA | 3 | 12 | WIN55212-2 | Surr | 1 | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 60 | 0 | log(Emax/EC50) | 0.0 | 8.9 | 5.4 | 0.0 | Gi1 | 0 | - | - | 100 | 98 | - | - | 93 | 91 | 97 | 0 | 0 | 0 | 60 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.9 | 8.7 | - | - | 8.3 | 8.1 | 8.7 | 0.0 | 0.0 | 0.0 | 5.4 | 0.0 | 0.0 | |||
CNR2 | CB2 | Cannabinoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 2 | 1 | - | Gi/o | 2 | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CNR2 | CB2 | Cannabinoid | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 2 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 60 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 98 | - | - | 93 | 91 | 97 | 0 | 0 | 0 | 60 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR18 | GPR18 | GPR18, GPR55 and GPR119 | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 1 | 1 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR18 | GPR18 | GPR18, GPR55 and GPR119 | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GPR18 | GPR18 | GPR18, GPR55 and GPR119 | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR55 | GPR55 | GPR18, GPR55 and GPR119 | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 1 | Gq/11 | 2 | - | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GPR55 | GPR55 | GPR18, GPR55 and GPR119 | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | 1 | Gq/11 | 2 | - | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | - | Inoue | TGF𝛼 | 5 | 1 | GSK-1292263 | Surr | 1 | - | 1 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.3 | - | - | - | - | - | |||
GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | - | 1 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GP119 | GPR119 | GPR18, GPR55 and GPR119 | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PTAFR | PAF | Platelet-activating factor | A | - | Inoue | TGF𝛼 | 5 | 1 | PAF | Phys | - | 1 | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.7 | - | - | - | - | - | |||
PTAFR | PAF | Platelet-activating factor | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 2 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
PTAFR | PAF | Platelet-activating factor | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 2 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PD2R | DP1 | Prostanoid | A | - | Inoue | NanoBiT-G | 1 | 8 | PGD2 | Phys | 3 | 1 | 2 | 1 | Gi/o | 4 | 2' | 1' | 3' | 4' | 96 | 100 | 92 | 90 | log(Emax/EC50) | 7.1 | 7.4 | 6.8 | 6.7 | Gi1 | - | 96 | - | 100 | 0 | 0 | - | - | 79 | - | 92 | - | - | - | 90 | 0 | log(Emax/EC50) | - | 7.1 | - | 7.4 | 0.0 | 0.0 | - | - | 5.9 | - | 6.8 | - | - | - | 6.7 | 0.0 | |||
PD2R | DP1 | Prostanoid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | PGD2 | Phys | 3 | 1 | 2 | 1 | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 22 | 0 | Activation rate (s-1) | 0.9 | 0.0 | 0.2 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 22 | - | 0 | Activation rate (s-1) | 0.9 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.2 | - | 0.0 | |||
PD2R | DP1 | Prostanoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 1 | 2 | 1 | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PD2R | DP1 | Prostanoid | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 1 | 2 | 1 | Gs | 4 | 1' | 3' | 2' | 4' | 98 | 50 | 57 | 45 | - | - | - | - | - | Gi1 | 100 | 96 | - | 100 | 0 | 0 | - | - | 40 | - | 46 | - | - | 22 | 90 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PD2R2 | DP2 | Prostanoid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | PGD2 | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.6 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.6 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
PD2R2 | DP2 | Prostanoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
PD2R2 | DP2 | Prostanoid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PE2R1 | EP1 | Prostanoid | A | - | Bouvier | GEMTA | 3 | 12 | PGE2 | Phys | - | 4 | 5 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 73 | 100 | 93 | log(Emax/EC50) | 0.0 | 6.7 | 9.2 | 8.6 | G15 | 0 | - | - | 57 | 64 | - | - | 0 | 73 | 67 | 84 | 85 | 78 | 100 | 93 | 76 | log(Emax/EC50) | 0.0 | - | - | 5.2 | 5.9 | - | - | 0.0 | 6.7 | 6.2 | 7.7 | 7.8 | 7.1 | 9.2 | 8.6 | 7.0 | |||
PE2R1 | EP1 | Prostanoid | A | - | Inoue | NanoBiT-G | 1 | 8 | PGE2 | Phys | - | 4 | 5 | 2 | G12/13 | 3 | nc | 2' | 3' | 1' | 0 | 84 | 74 | 100 | log(Emax/EC50) | 0.0 | 6.8 | 6.0 | 8.1 | G12 | - | 0 | - | 79 | 79 | 84 | - | - | 0 | - | 74 | - | - | - | 100 | 0 | log(Emax/EC50) | - | 0.0 | - | 6.4 | 6.4 | 6.8 | - | - | 0.0 | - | 6.0 | - | - | - | 8.1 | 0.0 | |||
PE2R1 | EP1 | Prostanoid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | PGE2 | Phys | - | 4 | 5 | 2 | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 22 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.6 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 22 | - | 100 | - | - | 67 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.6 | - | - | 0.4 | - | 0.0 | |||
PE2R1 | EP1 | Prostanoid | A | - | Inoue | TGF𝛼 | 5 | 1 | PGE2 | Phys | - | 4 | 5 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.5 | - | - | - | - | - | |||
PE2R1 | EP1 | Prostanoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 4 | 5 | 2 | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PE2R1 | EP1 | Prostanoid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 4 | 5 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 60 | 91 | 64 | - | - | - | - | - | G12 | 0 | 0 | - | 68 | 72 | 84 | - | 0 | 32 | 67 | 86 | 85 | 78 | 84 | 96 | 25 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PE2R2 | EP2 | Prostanoid | A | - | Bouvier | GEMTA | 3 | 12 | PGE2 | Phys | 4 | 2 | 1 | 2 | Gs | 4 | 1' | 4' | 2' | 3' | 100 | 53 | 60 | 56 | log(Emax/EC50) | 9.3 | 4.9 | 5.6 | 5.2 | GsL | 100 | - | - | 0 | 0 | - | - | 53 | 0 | 0 | 0 | 0 | 0 | 60 | 56 | 0 | log(Emax/EC50) | 9.3 | - | - | 0.0 | 0.0 | - | - | 4.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 5.6 | 5.2 | 0.0 | |||
PE2R2 | EP2 | Prostanoid | A | - | Inoue | NanoBiT-G | 1 | 8 | PGE2 | Phys | 4 | 2 | 1 | 2 | Gi/o | 3 | 2' | 1' | nc | 3' | 97 | 100 | 0 | 82 | log(Emax/EC50) | 7.4 | 7.6 | 0.0 | 6.2 | Gi1 | - | 97 | - | 100 | 82 | 0 | - | - | 85 | - | 0 | - | - | - | 82 | 78 | log(Emax/EC50) | - | 7.4 | - | 7.6 | 6.3 | 0.0 | - | - | 6.5 | - | 0.0 | - | - | - | 6.2 | 6.0 | |||
PE2R2 | EP2 | Prostanoid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | PGE2 | Phys | 4 | 2 | 1 | 2 | Gs | 1 | 1' | nc | 2' | nc | 100 | 0 | 2 | 0 | Activation rate (s-1) | 1.5 | 0.0 | 0.0 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 2 | - | 0 | Activation rate (s-1) | 1.5 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
PE2R2 | EP2 | Prostanoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 4 | 2 | 1 | 2 | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
PE2R2 | EP2 | Prostanoid | A | - | GproteinDb | merged data | - | - | - | - | - | 4 | 2 | 1 | 2 | Gs | 4 | 1' | 2' | 4' | 3' | 99 | 51 | 21 | 46 | - | - | - | - | - | GsL | 100 | 97 | - | 50 | 41 | 0 | - | 53 | 28 | 0 | 0 | 0 | 0 | 31 | 69 | 26 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PE2R3 | EP3 | Prostanoid | A | - | Bouvier | GEMTA | 3 | 12 | PGE2 | Phys | - | 4 | 3 | 3 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 79 | 85 | log(Emax/EC50) | 0.0 | 9.5 | 7.5 | 8.0 | Gi1 | 0 | - | - | 100 | 96 | - | - | 100 | 97 | 96 | 0 | 0 | 56 | 79 | 0 | 85 | log(Emax/EC50) | 0.0 | - | - | 9.4 | 9.1 | - | - | 9.5 | 9.1 | 9.1 | 0.0 | 0.0 | 5.3 | 7.5 | 0.0 | 8.0 | |||
PE2R3 | EP3 | Prostanoid | A | - | Inoue | NanoBiT-G | 1 | 8 | PGE2 | Phys | - | 4 | 3 | 3 | Gi/o | 2 | nc | 1' | nc | 2' | 0 | 100 | 0 | 89 | log(Emax/EC50) | 0.0 | 9.1 | 0.0 | 8.1 | GoA | - | 0 | - | 96 | 92 | 88 | - | - | 100 | - | 0 | - | - | - | 72 | 89 | log(Emax/EC50) | - | 0.0 | - | 8.8 | 8.4 | 8.0 | - | - | 9.1 | - | 0.0 | - | - | - | 6.6 | 8.1 | |||
PE2R3 | EP3 | Prostanoid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | PGE2 | Phys | - | 4 | 3 | 3 | Gi/o | 2 | nc | 1' | 3' | 2' | 0 | 100 | 2 | 4 | Activation rate (s-1) | 0.0 | 1.4 | 0.0 | 0.1 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 4 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.4 | - | 0.0 | - | - | 0.0 | - | 0.1 | |||
PE2R3 | EP3 | Prostanoid | A | - | Inoue | TGF𝛼 | 5 | 1 | PGE2 | Phys | - | 4 | 3 | 3 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.5 | - | - | - | - | - | |||
PE2R3 | EP3 | Prostanoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 4 | 3 | 3 | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PE2R3 | EP3 | Prostanoid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 4 | 3 | 3 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 27 | 59 | - | - | - | - | - | Gz | 0 | 0 | - | 98 | 94 | 88 | - | 100 | 99 | 96 | 0 | 0 | 56 | 40 | 36 | 59 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PE2R4 | EP4 | Prostanoid | A | - | Bouvier | GEMTA | 3 | 12 | PGE2 | Phys | 4 | 4 | 2 | 3 | Gs | 4 | 1' | 2' | 3' | 4' | 100 | 85 | 83 | 83 | log(Emax/EC50) | 10.5 | 8.9 | 8.7 | 8.7 | GsL | 100 | - | - | 85 | 79 | - | - | 69 | 0 | 67 | 0 | 0 | 0 | 83 | 83 | 75 | log(Emax/EC50) | 10.5 | - | - | 8.9 | 8.3 | - | - | 7.2 | 0.0 | 7.0 | 0.0 | 0.0 | 0.0 | 8.7 | 8.7 | 7.9 | |||
PE2R4 | EP4 | Prostanoid | A | - | Inoue | NanoBiT-G | 1 | 8 | PGE2 | Phys | 4 | 4 | 2 | 3 | G12/13 | 3 | 3' | 2' | nc | 1' | 82 | 90 | 0 | 100 | log(Emax/EC50) | 7.1 | 7.8 | 0.0 | 8.6 | G12 | - | 82 | - | 90 | 90 | 0 | - | - | 81 | - | 0 | - | - | - | 100 | 70 | log(Emax/EC50) | - | 7.1 | - | 7.8 | 7.7 | 0.0 | - | - | 7.0 | - | 0.0 | - | - | - | 8.6 | 6.1 | |||
PE2R4 | EP4 | Prostanoid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | PGE2 | Phys | 4 | 4 | 2 | 3 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 6 | 11 | 4 | Activation rate (s-1) | 1.7 | 0.1 | 0.2 | 0.1 | GsL | 100 | - | - | - | - | - | - | - | 6 | - | 0 | - | - | 11 | - | 4 | Activation rate (s-1) | 1.7 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.2 | - | 0.1 | |||
PE2R4 | EP4 | Prostanoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 4 | 4 | 2 | 3 | Gs | 2 | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PE2R4 | EP4 | Prostanoid | A | - | GproteinDb | merged data | - | - | - | - | - | 4 | 4 | 2 | 3 | Gs | 4 | 1' | 3' | 4' | 2' | 94 | 60 | 31 | 62 | - | - | - | - | - | GsL | 100 | 82 | - | 88 | 84 | 0 | - | 69 | 29 | 67 | 0 | 0 | 0 | 47 | 92 | 50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PF2R | FP | Prostanoid | A | - | Bouvier | GEMTA | 3 | 12 | PGD2 | Phys | 1 | 1 | 4 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 78 | 100 | 96 | log(Emax/EC50) | 0.0 | 6.6 | 8.5 | 8.2 | G15 | 0 | - | - | 63 | 0 | - | - | 78 | 69 | 72 | 96 | 98 | 93 | 100 | 89 | 96 | log(Emax/EC50) | 0.0 | - | - | 5.3 | 0.0 | - | - | 6.6 | 5.9 | 6.1 | 8.2 | 8.3 | 7.9 | 8.5 | 7.5 | 8.2 | |||
PF2R | FP | Prostanoid | A | - | Inoue | NanoBiT-G | 1 | 8 | PGF2-1-ethanolamide | Surr | 1 | 1 | 4 | 2 | G12/13 | 2 | nc | nc | 2' | 1' | 0 | 0 | 96 | 100 | log(Emax/EC50) | 0.0 | 0.0 | 6.1 | 6.4 | G12 | - | 0 | - | 0 | 0 | 0 | - | - | 0 | - | 96 | - | - | - | 100 | 98 | log(Emax/EC50) | - | 0.0 | - | 0.0 | 0.0 | 0.0 | - | - | 0.0 | - | 6.1 | - | - | - | 6.4 | 6.2 | |||
PF2R | FP | Prostanoid | A | - | Inoue | TGF𝛼 | 5 | 1 | PGF2α | Phys | 1 | 1 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.6 | - | - | - | - | - | |||
PF2R | FP | Prostanoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | 4 | 2 | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PF2R | FP | Prostanoid | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 4 | 2 | Gq/11 | 3 | nc | 3' | 1' | 2' | 0 | 39 | 98 | 98 | - | - | - | - | - | G15 | 0 | 0 | - | 32 | 0 | 0 | - | 78 | 34 | 72 | 96 | 98 | 93 | 100 | 94 | 97 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PI2R | IP | Prostanoid | A | - | Inoue | NanoBiT-G | 1 | 8 | iloprost | Surr | 2 | 2 | 3 | 1 | G12/13 | 4 | 2' | 3' | 4' | 1' | 99 | 98 | 96 | 100 | log(Emax/EC50) | 8.6 | 8.5 | 8.3 | 8.7 | G12 | - | 99 | - | 98 | 97 | 0 | - | - | 83 | - | 96 | - | - | - | 100 | 91 | log(Emax/EC50) | - | 8.6 | - | 8.5 | 8.4 | 0.0 | - | - | 7.2 | - | 8.3 | - | - | - | 8.7 | 7.9 | |||
PI2R | IP | Prostanoid | A | - | Inoue | TGF𝛼 | 5 | 1 | iloprost | Surr | 2 | 2 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.0 | - | - | - | - | - | |||
PI2R | IP | Prostanoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 2 | 2 | 3 | 1 | Gs | 3 | 1' | 2' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
PI2R | IP | Prostanoid | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 2 | 3 | 1 | G12/13 | 4 | 2' | 3' | 4' | 1' | 99 | 98 | 96 | 100 | - | - | - | - | - | G12 | - | 99 | - | 98 | 97 | 0 | - | - | 83 | - | 96 | - | - | - | 100 | 91 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
TA2R | TP | Prostanoid | A | - | Inoue | NanoBiT-G | 1 | 8 | U46619 | Surr | - | - | 5 | 3 | G12/13 | 2 | nc | nc | 2' | 1' | 0 | 0 | 82 | 100 | log(Emax/EC50) | 0.0 | 0.0 | 7.2 | 8.7 | G12 | - | 0 | - | 0 | 0 | 0 | - | - | 0 | - | 82 | - | - | - | 100 | 95 | log(Emax/EC50) | - | 0.0 | - | 0.0 | 0.0 | 0.0 | - | - | 0.0 | - | 7.2 | - | - | - | 8.7 | 8.3 | |||
TA2R | TP | Prostanoid | A | - | Lambert | RGB-GDP | 0 | 6 | U46619 | Surr | - | - | 5 | 3 | Gq/11 | 2 | nc | nc | 1' | 2' | 0 | 0 | 100 | 43 | Efficacy | 0.00 | 0.00 | 0.02 | 0.01 | Gq | 0 | - | - | 0 | - | - | - | - | - | - | 100 | - | - | - | 43 | - | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.02 | - | - | - | 0.01 | - | |||
TA2R | TP | Prostanoid | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | 5 | 3 | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
TA2R | TP | Prostanoid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | PGH2 | Phys | - | - | 5 | 3 | G12/13 | 2 | nc | nc | 2' | 1' | 0 | 0 | 43 | 100 | Activation rate (s-1) | 0.0 | 0.0 | 0.2 | 0.5 | G13 | 0 | - | - | - | - | - | - | - | 0 | - | 43 | - | - | 18 | - | 100 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.0 | - | 0.2 | - | - | 0.1 | - | 0.5 | |||
TA2R | TP | Prostanoid | A | - | Inoue | TGF𝛼 | 5 | 1 | U46619 | Surr | - | - | 5 | 3 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.8 | - | - | - | - | - | |||
TA2R | TP | Prostanoid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 5 | 3 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
TA2R | TP | Prostanoid | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 5 | 3 | G12/13 | 2 | nc | nc | 2' | 1' | 0 | 0 | 56 | 61 | - | - | - | - | - | G13 | 0 | 0 | - | 0 | 0 | 0 | - | - | 0 | - | 56 | - | - | 18 | 48 | 98 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MTR1A | MT1 | Melatonin | A | - | Bouvier | GEMTA | 3 | 12 | melatonin | Phys | - | 3 | 3 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 89 | 0 | log(Emax/EC50) | 0.0 | 10.1 | 9.0 | 0.0 | Gi1 | 0 | - | - | 100 | 99 | - | - | 0 | 98 | 99 | 0 | 0 | 0 | 89 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 10.1 | 10.0 | - | - | 0.0 | 9.9 | 10.0 | 0.0 | 0.0 | 0.0 | 9.0 | 0.0 | 0.0 | |||
MTR1A | MT1 | Melatonin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | melatonin | Phys | - | 3 | 3 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 6 | 0 | Activation rate (s-1) | 0.0 | 1.2 | 0.1 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 6 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 1.2 | - | 0.0 | - | - | 0.1 | - | 0.0 | |||
MTR1A | MT1 | Melatonin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 3 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MTR1A | MT1 | Melatonin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 3 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 48 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 99 | - | - | 0 | 99 | 99 | 0 | 0 | 0 | 48 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MTR1B | MT2 | Melatonin | A | - | Bouvier | GEMTA | 3 | 12 | melatonin | Phys | - | 3 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 76 | 0 | log(Emax/EC50) | 0.0 | 8.8 | 6.7 | 0.0 | Gi1 | 0 | - | - | 100 | 98 | - | - | 0 | 91 | 97 | 0 | 0 | 0 | 76 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.8 | 8.7 | - | - | 0.0 | 8.0 | 8.6 | 0.0 | 0.0 | 0.0 | 6.7 | 0.0 | 0.0 | |||
MTR1B | MT2 | Melatonin | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | melatonin | Phys | - | 3 | 1 | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | Activation rate (s-1) | 0.0 | 0.6 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.6 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
MTR1B | MT2 | Melatonin | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 1 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MTR1B | MT2 | Melatonin | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 38 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 98 | - | - | 0 | 96 | 97 | 0 | 0 | 0 | 38 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AA1R | A1 | Adenosine | A | - | Bouvier | GEMTA | 3 | 12 | adenosine | Phys | 1 | 5 | 3 | 1 | Gq/11 | 3 | nc | 2' | 1' | 3' | 0 | 94 | 100 | 74 | log(Emax/EC50) | 0.0 | 6.2 | 6.6 | 4.9 | G15 | 0 | - | - | 86 | 85 | - | - | 86 | 94 | 93 | 0 | 0 | 0 | 100 | 74 | 0 | log(Emax/EC50) | 0.0 | - | - | 5.7 | 5.6 | - | - | 5.7 | 6.2 | 6.2 | 0.0 | 0.0 | 0.0 | 6.6 | 4.9 | 0.0 | |||
AA1R | A1 | Adenosine | A | - | Lambert | RGB-GDP | 0 | 6 | adenosine | Phys | 1 | 5 | 3 | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.05 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.05 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
AA1R | A1 | Adenosine | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 5 | 3 | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.10 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.10 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
AA1R | A1 | Adenosine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | adenosine | Phys | 1 | 5 | 3 | 1 | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 13 | 0 | Activation rate (s-1) | 0.0 | 5.4 | 0.7 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 13 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 5.4 | - | 0.0 | - | - | 0.7 | - | 0.0 | |||
AA1R | A1 | Adenosine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 5 | 3 | 1 | Gi/o | 3 | 2' | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AA1R | A1 | Adenosine | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 5 | 3 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 98 | 28 | 18 | - | - | - | - | - | GoA | 0 | - | - | 95 | 85 | - | - | 86 | 97 | 93 | 0 | 0 | 0 | 56 | 25 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AA2AR | A2A | Adenosine | A | - | Bouvier | GEMTA | 3 | 12 | adenosine | Phys | 3 | 1 | 3 | 1 | Gs | 3 | 1' | nc | 3' | 2' | 100 | 0 | 96 | 99 | log(Emax/EC50) | 5.8 | 0.0 | 5.6 | 5.8 | GsL | 100 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 0 | 0 | 0 | 96 | 99 | 94 | log(Emax/EC50) | 5.8 | - | - | 0.0 | 0.0 | - | - | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 5.6 | 5.8 | 5.5 | |||
AA2AR | A2A | Adenosine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | adenosine | Phys | 3 | 1 | 3 | 1 | Gs | 3 | 1' | 3' | 2' | nc | 100 | 7 | 38 | 0 | Activation rate (s-1) | 1.6 | 0.1 | 0.6 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 7 | - | 0 | - | - | 38 | - | 0 | Activation rate (s-1) | 1.6 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.6 | - | 0.0 | |||
AA2AR | A2A | Adenosine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 1 | 3 | 1 | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AA2AR | A2A | Adenosine | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 1 | 3 | 1 | Gs | 4 | 1' | 4' | 2' | 3' | 100 | 4 | 67 | 50 | - | - | - | - | - | GsL | 100 | - | - | 0 | 0 | - | - | 0 | 4 | 0 | 0 | 0 | 0 | 67 | 99 | 47 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AA2BR | A2B | Adenosine | A | - | Bouvier | GEMTA | 3 | 12 | adenosine | Phys | 3 | 1 | 3 | 1 | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 100 | 0 | log(Emax/EC50) | 6.0 | 0.0 | 6.0 | 0.0 | GsL | 100 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 0 | 0 | 0 | 100 | 0 | 0 | log(Emax/EC50) | 6.0 | - | - | 0.0 | 0.0 | - | - | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 0.0 | 0.0 | |||
AA2BR | A2B | Adenosine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | adenosine | Phys | 3 | 1 | 3 | 1 | Gq/11 | 4 | 2' | 3' | 1' | 4' | 78 | 17 | 100 | 10 | Activation rate (s-1) | 0.7 | 0.2 | 0.9 | 0.1 | G15 | 78 | - | - | - | - | - | - | - | 17 | - | 0 | - | - | 100 | - | 10 | Activation rate (s-1) | 0.7 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.9 | - | 0.1 | |||
AA2BR | A2B | Adenosine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 3 | 1 | 3 | 1 | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
AA2BR | A2B | Adenosine | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 1 | 3 | 1 | Gq/11 | 4 | 2' | 3' | 1' | 4' | 89 | 8 | 100 | 5 | - | - | - | - | - | G15 | 89 | - | - | 0 | 0 | - | - | 0 | 8 | 0 | 0 | 0 | 0 | 100 | 0 | 5 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AA3R | A3 | Adenosine | A | - | Bouvier | GEMTA | 3 | 12 | adenosine | Phys | - | 3 | 2 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 94 | 100 | 0 | log(Emax/EC50) | 0.0 | 6.6 | 7.1 | 0.0 | G15 | 0 | - | - | 94 | 92 | - | - | 0 | 71 | 82 | 0 | 0 | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 6.6 | 6.5 | - | - | 0.0 | 5.0 | 5.8 | 0.0 | 0.0 | 0.0 | 7.1 | 0.0 | 0.0 | |||
AA3R | A3 | Adenosine | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | adenosine | Phys | - | 3 | 2 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 50 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.3 | 0.0 | G15 | 0 | - | - | - | - | - | - | - | 50 | - | 0 | - | - | 100 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.3 | - | 0.0 | |||
AA3R | A3 | Adenosine | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 2 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
AA3R | A3 | Adenosine | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 2 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 72 | 100 | 0 | - | - | - | - | - | G15 | 0 | - | - | 94 | 92 | - | - | 0 | 60 | 82 | 0 | 0 | 0 | 100 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2RY1 | P2Y1 | P2Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 1 | - | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2RY1 | P2Y1 | P2Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gq/11 | 2 | - | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2RY2 | P2Y2 | P2Y | A | - | Bouvier | GEMTA | 3 | 12 | UTP | Phys | - | 2 | 2 | 1 | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 96 | 100 | 0 | log(Emax/EC50) | 0.0 | 5.1 | 5.3 | 0.0 | G15 | 0 | - | - | 95 | 93 | - | - | 94 | 92 | 96 | 91 | 90 | 88 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 5.1 | 5.0 | - | - | 5.0 | 4.9 | 5.1 | 4.8 | 4.8 | 4.7 | 5.3 | 0.0 | 0.0 | |||
P2RY2 | P2Y2 | P2Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 2 | 1 | Gq/11 | 3 | - | 2' | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2RY2 | P2Y2 | P2Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 2 | 1 | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 96 | 100 | 0 | - | - | - | - | - | G15 | 0 | - | - | 95 | 93 | - | - | 94 | 92 | 96 | 91 | 90 | 88 | 100 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2RY4 | P2Y4 | P2Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2RY4 | P2Y4 | P2Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2RY6 | P2Y6 | P2Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 1 | 1 | Gq/11 | 2 | - | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2RY6 | P2Y6 | P2Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | 1 | Gq/11 | 2 | - | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2Y11 | P2Y11 | P2Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | - | 1 | - | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
P2Y11 | P2Y11 | P2Y | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gq/11 | 2 | 2' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2Y13 | P2Y13 | P2Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2Y13 | P2Y13 | P2Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2Y14 | P2Y14 | P2Y | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2Y14 | P2Y14 | P2Y | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPBAR | GPBA | Bile acid | A | - | Bouvier | GEMTA | 3 | 12 | lithocholic acid | Phys | 3 | - | - | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | log(Emax/EC50) | 5.9 | 0.0 | 0.0 | 0.0 | GsL | 100 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 5.9 | - | - | 0.0 | 0.0 | - | - | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
GPBAR | GPBA | Bile acid | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | deoxycholic acid | Phys | 3 | - | - | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | Activation rate (s-1) | 0.3 | 0.0 | 0.0 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.3 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
GPBAR | GPBA | Bile acid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPBAR | GPBA | Bile acid | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | - | - | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | - | - | - | - | - | GsL | 100 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPER1 | GPER | Estrogen (G protein-coupled) | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 1 | - | - | Gi/o | 2 | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GPER1 | GPER | Estrogen (G protein-coupled) | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | - | - | Gi/o | 2 | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
HCAR1 | HCA1 | Hydroxycarboxylic acid | A | - | Lambert | RGB-GDP | 0 | 6 | - | L-lactic acid | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.05 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.05 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
HCAR1 | HCA1 | Hydroxycarboxylic acid | A | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.04 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.04 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
HCAR1 | HCA1 | Hydroxycarboxylic acid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
HCAR1 | HCA1 | Hydroxycarboxylic acid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
HCAR2 | HCA2 | Hydroxycarboxylic acid | A | - | Bouvier | GEMTA | 3 | 12 | nicotinic acid | Phys | - | 4 | - | 1 | Gi/o | 2 | nc | 1' | nc | 2' | 0 | 100 | 0 | 82 | log(Emax/EC50) | 0.0 | 6.9 | 0.0 | 5.7 | Gi1 | 0 | - | - | 100 | 96 | - | - | 92 | 94 | 96 | 0 | 0 | 0 | 0 | 0 | 82 | log(Emax/EC50) | 0.0 | - | - | 6.9 | 6.7 | - | - | 6.4 | 6.5 | 6.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 5.7 | |||
HCAR2 | HCA2 | Hydroxycarboxylic acid | A | - | Lambert | RGB-GDP | 0 | 6 | - | β-D-hydroxybutyric acid | Phys | - | 4 | - | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.05 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.05 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
HCAR2 | HCA2 | Hydroxycarboxylic acid | A | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | 4 | - | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.05 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.05 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
HCAR2 | HCA2 | Hydroxycarboxylic acid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 4 | - | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
HCAR2 | HCA2 | Hydroxycarboxylic acid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 4 | - | 1 | Gi/o | 2 | nc | 1' | nc | 2' | 0 | 100 | 0 | 27 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 96 | - | - | 92 | 94 | 96 | 0 | 0 | 0 | 0 | 0 | 82 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
HCAR3 | HCA3 | Hydroxycarboxylic acid | A | - | Bouvier | GEMTA | 3 | 12 | 3-hydroxyoctanoic acid | Phys | - | 4 | - | 1 | Gi/o | 2 | nc | 1' | nc | 2' | 0 | 100 | 0 | 61 | log(Emax/EC50) | 0.0 | 5.3 | 0.0 | 3.2 | Gi1 | 0 | - | - | 100 | 95 | - | - | 86 | 91 | 94 | 0 | 0 | 0 | 0 | 0 | 61 | log(Emax/EC50) | 0.0 | - | - | 5.3 | 5.0 | - | - | 4.5 | 4.8 | 5.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.2 | |||
HCAR3 | HCA3 | Hydroxycarboxylic acid | A | - | Lambert | RGB-GDP | 0 | 6 | - | nicotinic acid | Phys | - | 4 | - | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.06 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Efficacy | 0.00 | - | - | 0.06 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
HCAR3 | HCA3 | Hydroxycarboxylic acid | A | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | 4 | - | 1 | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.06 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.06 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | ||
HCAR3 | HCA3 | Hydroxycarboxylic acid | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 4 | - | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
HCAR3 | HCA3 | Hydroxycarboxylic acid | A | - | GproteinDb | merged data | - | - | - | - | - | - | 4 | - | 1 | Gi/o | 2 | nc | 1' | nc | 2' | 0 | 100 | 0 | 20 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 95 | - | - | 86 | 91 | 94 | 0 | 0 | 0 | 0 | 0 | 61 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OXGR1 | Oxoglutarate | Oxoglutarate | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | α-ketoglutaric acid | Phys | - | 1 | 2 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 41 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.2 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 41 | - | 100 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.2 | - | - | 0.0 | - | 0.0 | |||
OXGR1 | Oxoglutarate | Oxoglutarate | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 2 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
OXGR1 | Oxoglutarate | Oxoglutarate | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 2 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 41 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 41 | - | 100 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SUCR1 | Succinate | Succinate | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | succinic acid | Phys | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.1 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
SUCR1 | Succinate | Succinate | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
SUCR1 | Succinate | Succinate | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OPN4 | OPN4 | Opsins | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OPN4 | OPN4 | Opsins | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OPN5 | OPN5 | Opsins | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OPN5 | OPN5 | Opsins | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR6 | GPR6 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 1 | - | - | Gs | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GPR6 | GPR6 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | - | - | Gs | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR12 | GPR12 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | 1 | 1 | - | - | Gs | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GPR12 | GPR12 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | - | - | Gs | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR17 | GPR17 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GPR17 | GPR17 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR19 | GPR19 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR19 | GPR19 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR20 | GPR20 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.07 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.07 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR20 | GPR20 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR20 | GPR20 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR21 | GPR21 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | - | 1 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 43 | 0 | Econstitutive | 0.03 | 0.00 | 0.01 | 0.00 | GsL | 100 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 43 | - | 0 | Econstitutive | 0.03 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.01 | - | 0.00 | |||
GPR21 | GPR21 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 43 | 0 | - | - | - | - | - | GsL | 100 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 43 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR22 | GPR22 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.05 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.05 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR22 | GPR22 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR22 | GPR22 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR25 | GPR25 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 1 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.01 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.01 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR25 | GPR25 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR26 | GPR26 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 2 | 1 | 1 | - | Gs | 3 | 1' | 2' | 3' | nc | 100 | 63 | 47 | 0 | Econstitutive | 0.05 | 0.03 | 0.02 | 0.00 | GsL | 100 | - | - | 63 | - | - | - | - | - | - | 17 | - | - | 47 | - | 0 | Econstitutive | 0.05 | - | - | 0.03 | - | - | - | - | - | - | 0.01 | - | - | 0.02 | - | 0.00 | |||
GPR26 | GPR26 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | 1 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR26 | GPR26 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 1 | 1 | - | Gs | 3 | 1' | 2' | 3' | nc | 100 | 63 | 47 | 0 | - | - | - | - | - | GsL | 100 | - | - | 63 | - | - | - | - | - | - | 17 | - | - | 47 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR27 | GPR27 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | 1 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR27 | GPR27 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR27 | GPR27 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR31 | GPR31 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 1 | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR31 | GPR31 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GPR31 | GPR31 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR32 | GPR32 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 1 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 69 | 0 | Econstitutive | 0.00 | 0.05 | 0.04 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 69 | - | 0 | Econstitutive | 0.00 | - | - | 0.05 | - | - | - | - | - | - | 0.00 | - | - | 0.04 | - | 0.00 | |||
GPR32 | GPR32 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 69 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 69 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR33 | GPR33 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR33 | GPR33 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR34 | GPR34 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.12 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.12 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR34 | GPR34 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GPR34 | GPR34 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR35 | GPR35 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | zaprinast | Surr | - | - | - | 1 | G12/13 | 1 | nc | nc | nc | 1' | 0 | 0 | 0 | 100 | Efficacy | 0.00 | 0.00 | 0.00 | 0.02 | G12 | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 100 | - | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.02 | - | |||
GPR35 | GPR35 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | 1 | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 0 | - | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | - | 0.00 | - | |||
GPR35 | GPR35 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | 1 | G12/13 | 1 | nc | nc | nc | 1' | 0 | 0 | 0 | 50 | - | - | - | - | - | G12 | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | - | 50 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR37 | GPR37 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GPR37 | GPR37 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
G37L1 | GPR37L1 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 1 | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
G37L1 | GPR37L1 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
G37L1 | GPR37L1 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR39 | GPR39 | A orphans | A | - | Bouvier | GEMTA | 3 | 12 | Zn2+ | Phys | 1 | 1 | 2 | 2 | G12/13 | 3 | nc | 2' | 3' | 1' | 0 | 77 | 77 | 100 | log(Emax/EC50) | 0.0 | 3.6 | 3.5 | 4.6 | G13 | 0 | - | - | 77 | 68 | - | - | 0 | 72 | 77 | 76 | 72 | 77 | 63 | 0 | 100 | log(Emax/EC50) | 0.0 | - | - | 3.5 | 3.1 | - | - | 0.0 | 3.3 | 3.6 | 3.5 | 3.3 | 3.5 | 2.9 | 0.0 | 4.6 | |||
GPR39 | GPR39 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | 2 | 2 | Gq/11 | 3 | 2' | - | 1' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR39 | GPR39 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 2 | 2 | G12/13 | 3 | nc | 2' | 3' | 1' | 0 | 77 | 77 | 100 | - | - | - | - | - | G13 | 0 | - | - | 77 | 68 | - | - | 0 | 72 | 77 | 76 | 72 | 77 | 63 | 0 | 100 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR45 | GPR45 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR45 | GPR45 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR52 | GPR52 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 2 | 1 | 2 | - | Gq/11 | 2 | 2' | nc | 1' | nc | 82 | 0 | 100 | 0 | Econstitutive | 0.03 | 0.00 | 0.03 | 0.00 | G15 | 82 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 100 | - | 0 | Econstitutive | 0.03 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.03 | - | 0.00 | |||
GPR52 | GPR52 | A orphans | A | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | TP-024 | Surr | 2 | 1 | 2 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 47 | 62 | 0 | Activation rate (s-1) | 0.2 | 0.1 | 0.1 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 47 | - | 0 | - | - | 62 | - | 0 | Activation rate (s-1) | 0.2 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.1 | - | 0.0 | |||
GPR52 | GPR52 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | 1 | 2 | - | Gs | 3 | 1' | 3' | 2' | nc | 91 | 24 | 81 | 0 | - | - | - | - | - | GsL | 91 | - | - | 0 | - | - | - | - | 47 | - | 0 | - | - | 81 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR61 | GPR61 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | 1 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | Econstitutive | 0.00 | 0.00 | 0.01 | 0.00 | G15 | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 100 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.01 | - | 0.00 | |||
GPR61 | GPR61 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | nc | nc | 1' | nc | 0 | 0 | 100 | 0 | - | - | - | - | - | G15 | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 100 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR62 | GPR62 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 1 | 1 | - | Gs | 3 | 1' | 2' | 3' | nc | 100 | 92 | 71 | 0 | Econstitutive | 0.02 | 0.02 | 0.01 | 0.00 | GsL | 100 | - | - | 92 | - | - | - | - | - | - | 0 | - | - | 71 | - | 0 | Econstitutive | 0.02 | - | - | 0.02 | - | - | - | - | - | - | 0.00 | - | - | 0.01 | - | 0.00 | |||
GPR62 | GPR62 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | 1 | - | Gs | 3 | 1' | 2' | 3' | nc | 100 | 92 | 71 | 0 | - | - | - | - | - | GsL | 100 | - | - | 92 | - | - | - | - | - | - | 0 | - | - | 71 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR63 | GPR63 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR63 | GPR63 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PSYR | GPR65 | A orphans | A | - | Bouvier | GEMTA | 3 | 12 | pH (proton) | Phys | 3 | 2 | - | 2 | G12/13 | 3 | 2' | 3' | nc | 1' | 94 | 74 | 0 | 100 | log(Emax/EC50) | 6.7 | 5.3 | 0.0 | 7.1 | G13 | 94 | - | - | 0 | 0 | - | - | 0 | 0 | 74 | 0 | 0 | 0 | 0 | 0 | 100 | log(Emax/EC50) | 6.7 | - | - | 0.0 | 0.0 | - | - | 0.0 | 0.0 | 5.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 7.1 | |||
PSYR | GPR65 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 3 | 2 | - | 2 | G12/13 | 3 | 2' | 3' | nc | 1' | 52 | 27 | 0 | 100 | Econstitutive | 0.02 | 0.01 | 0.00 | 0.05 | G13 | 52 | - | - | 27 | - | - | - | - | - | - | 0 | - | - | 0 | - | 100 | Econstitutive | 0.02 | - | - | 0.01 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.05 | |||
PSYR | GPR65 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 2 | - | 2 | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PSYR | GPR65 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 3 | 2 | - | 2 | G12/13 | 3 | 2' | 3' | nc | 1' | 73 | 50 | 0 | 100 | - | - | - | - | - | G13 | 73 | - | - | 14 | 0 | - | - | 0 | 0 | 74 | 0 | 0 | 0 | 0 | 0 | 100 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OGR1 | GPR68 | A orphans | A | - | Bouvier | GEMTA | 3 | 12 | pH (proton) | Phys | 1 | 3 | 3 | 2 | Gq/11 | 4 | 4' | 3' | 1' | 2' | 88 | 98 | 100 | 99 | log(Emax/EC50) | 6.3 | 7.1 | 7.2 | 7.2 | Gq | 88 | - | - | 88 | 87 | - | - | 0 | 92 | 98 | 100 | 100 | 98 | 84 | 92 | 99 | log(Emax/EC50) | 6.3 | - | - | 6.4 | 6.3 | - | - | 0.0 | 6.7 | 7.1 | 7.2 | 7.2 | 7.1 | 6.1 | 6.7 | 7.2 | |||
OGR1 | GPR68 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 3 | 3 | 2 | G12/13 | 3 | nc | 3' | 2' | 1' | 0 | 41 | 65 | 100 | Econstitutive | 0.00 | 0.02 | 0.04 | 0.06 | G13 | 0 | - | - | 41 | - | - | - | - | - | - | 65 | - | - | 0 | - | 100 | Econstitutive | 0.00 | - | - | 0.02 | - | - | - | - | - | - | 0.04 | - | - | 0.00 | - | 0.06 | |||
OGR1 | GPR68 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 3 | 2 | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
OGR1 | GPR68 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 3 | 2 | G12/13 | 4 | 4' | 3' | 2' | 1' | 44 | 70 | 82 | 100 | - | - | - | - | - | G11 | 44 | - | - | 64 | 87 | - | - | 0 | 92 | 98 | 82 | 100 | 98 | 42 | 92 | 100 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR75 | GPR75 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 1 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.01 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.01 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR75 | GPR75 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GPR75 | GPR75 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR78 | GPR78 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 2 | - | - | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | Econstitutive | 0.02 | 0.00 | 0.00 | 0.00 | GsL | 100 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.02 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR78 | GPR78 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR78 | GPR78 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 2 | - | - | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | - | - | - | - | - | GsL | 100 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR82 | GPR82 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 1 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.09 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.09 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR82 | GPR82 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR84 | GPR84 | A orphans | A | - | Bouvier | GEMTA | 3 | 12 | undecanoic acid | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 3.8 | 0.0 | 0.0 | Gz | 0 | - | - | 88 | 81 | - | - | 100 | 43 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 3.3 | 3.1 | - | - | 3.8 | 1.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
GPR84 | GPR84 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GPR84 | GPR84 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gz | 0 | - | - | 88 | 81 | - | - | 100 | 43 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR85 | GPR85 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR85 | GPR85 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR87 | GPR87 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 1 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 22 | 0 | Econstitutive | 0.00 | 0.13 | 0.03 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 22 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.13 | - | - | - | - | - | - | 0.03 | - | - | 0.00 | - | 0.00 | |||
GPR87 | GPR87 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 22 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 22 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPR88 | GPR88 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 1 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Econstitutive | 0.00 | 0.07 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.07 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GPR88 | GPR88 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP101 | GPR101 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP101 | GPR101 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP132 | GPR132 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 1 | - | 1 | Gi/o | 2 | nc | 1' | nc | 2' | 0 | 100 | 0 | 97 | Econstitutive | 0.00 | 0.01 | 0.00 | 0.01 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 97 | Econstitutive | 0.00 | - | - | 0.01 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.01 | |||
GP132 | GPR132 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | 1 | Gi/o | 2 | nc | 1' | nc | 2' | 0 | 100 | 0 | 97 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | - | 97 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP135 | GPR135 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP135 | GPR135 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP139 | GPR139 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 1 | 2 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 40 | 24 | Econstitutive | 0.00 | 0.06 | 0.02 | 0.01 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 36 | - | - | 40 | - | 24 | Econstitutive | 0.00 | - | - | 0.06 | - | - | - | - | - | - | 0.02 | - | - | 0.02 | - | 0.01 | |||
GP139 | GPR139 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 2 | 1 | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP139 | GPR139 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 2 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 40 | 24 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 36 | - | - | 40 | - | 24 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP142 | GPR142 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP142 | GPR142 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP146 | GPR146 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP146 | GPR146 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP148 | GPR148 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP148 | GPR148 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP149 | GPR149 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP149 | GPR149 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP150 | GPR150 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP150 | GPR150 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP151 | GPR151 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP151 | GPR151 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP152 | GPR152 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP152 | GPR152 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP153 | GPR153 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP153 | GPR153 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP160 | GPR160 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP160 | GPR160 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP162 | GPR162 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP162 | GPR162 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP171 | GPR171 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP171 | GPR171 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP173 | GPR173 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP173 | GPR173 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP174 | GPR174 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | 1 | 1 | - | 1 | Gs | 3 | 1' | 3' | nc | 2' | 100 | 12 | 0 | 41 | Econstitutive | 0.08 | 0.01 | 0.00 | 0.03 | GsL | 100 | - | - | 12 | - | - | - | - | - | - | 0 | - | - | 0 | - | 41 | Econstitutive | 0.08 | - | - | 0.01 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.03 | |||
GP174 | GPR174 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | - | 1 | Gs | 3 | 1' | 3' | nc | 2' | 100 | 12 | 0 | 41 | - | - | - | - | - | GsL | 100 | - | - | 12 | - | - | - | - | - | - | 0 | - | - | 0 | - | 41 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP182 | GPR182 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP182 | GPR182 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP183 | GPR183 | A orphans | A | - | Bouvier | GEMTA | 3 | 12 | 7α,25-dihydroxycholesterol | Phys | - | 2 | 1 | 1 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 78 | 87 | log(Emax/EC50) | 0.0 | 9.1 | 7.1 | 7.9 | GoB | 0 | - | - | 98 | 99 | - | - | 91 | 93 | 100 | 0 | 0 | 0 | 78 | 87 | 0 | log(Emax/EC50) | 0.0 | - | - | 8.9 | 8.9 | - | - | 8.3 | 8.4 | 9.1 | 0.0 | 0.0 | 0.0 | 7.1 | 7.9 | 0.0 | |||
GP183 | GPR183 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GP183 | GPR183 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 1 | 1 | Gi/o | 3 | nc | 1' | 3' | 2' | 0 | 100 | 78 | 87 | - | - | - | - | - | GoB | 0 | - | - | 98 | 99 | - | - | 91 | 93 | 100 | 0 | 0 | 0 | 78 | 87 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MAS | MAS1 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
MAS | MAS1 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MRGRD | MRGPRD | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 2 | 2 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 50 | 45 | Econstitutive | 0.00 | 0.11 | 0.06 | 0.05 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 37 | - | - | 50 | - | 45 | Econstitutive | 0.00 | - | - | 0.11 | - | - | - | - | - | - | 0.04 | - | - | 0.06 | - | 0.05 | |||
MRGRD | MRGPRD | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | 2 | 1 | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MRGRD | MRGPRD | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | 2 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 50 | 45 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 37 | - | - | 50 | - | 45 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MRGRE | MRGPRE | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
MRGRE | MRGPRE | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MRGRF | MRGPRF | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
MRGRF | MRGPRF | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MRGRG | MRGPRG | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
MRGRG | MRGPRG | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MRGX1 | MRGPRX1 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MRGX1 | MRGPRX1 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MRGX2 | MRGPRX2 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
MRGX2 | MRGPRX2 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MRGX3 | MRGPRX3 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MRGX3 | MRGPRX3 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MRGX4 | MRGPRX4 | A orphans | A | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
MRGX4 | MRGPRX4 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
P2Y10 | P2RY10 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | 18:1 Lyso PS | Phys | - | 2 | - | 2 | G12/13 | 2 | nc | 2' | nc | 1' | 0 | 98 | 0 | 100 | Efficacy | 0.00 | 0.03 | 0.00 | 0.03 | G12 | 0 | - | - | 98 | - | - | - | - | - | - | 0 | - | - | - | 100 | - | Efficacy | 0.00 | - | - | 0.03 | - | - | - | - | - | - | 0.00 | - | - | - | 0.03 | - | |||
P2Y10 | P2RY10 | A orphans | A | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | 2 | - | 2 | Gi/o | 2 | nc | 1' | nc | 2' | 0 | 100 | 0 | 97 | Econstitutive | 0.00 | 0.02 | 0.00 | 0.02 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | - | 97 | - | Econstitutive | 0.00 | - | - | 0.02 | - | - | - | - | - | - | 0.00 | - | - | - | 0.02 | - | |||
P2Y10 | P2RY10 | A orphans | A | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | 2 | Gi/o | 2 | nc | 1' | nc | 2' | 0 | 99 | 0 | 98 | - | - | - | - | - | Gi1 | 0 | - | - | 99 | - | - | - | - | - | - | 0 | - | - | - | 98 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CALCR | CT | Calcitonin | B1 | - | Bouvier | GEMTA | 3 | 12 | Human Calcitonin (hCT) | Phys | 3 | 2 | 3 | 1 | Gs | 4 | 1' | 4' | 2' | 3' | 100 | 74 | 89 | 82 | log(Emax/EC50) | 11.7 | 8.7 | 10.4 | 9.6 | GsL | 100 | - | - | 68 | 68 | - | - | 63 | 68 | 74 | 68 | 62 | 67 | 89 | 72 | 82 | log(Emax/EC50) | 11.7 | - | - | 8.0 | 8.0 | - | - | 7.4 | 8.0 | 8.7 | 7.9 | 7.3 | 7.8 | 10.4 | 8.5 | 9.6 | |||
CALCR | CT | Calcitonin | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | Human Calcitonin (hCT) | Phys | 3 | 2 | 3 | 1 | Gs | 3 | 1' | 3' | 2' | 4' | 100 | 22 | 31 | 11 | Activation rate (s-1) | 0.4 | 0.1 | 0.1 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 22 | - | 0 | - | - | 31 | - | 11 | Activation rate (s-1) | 0.4 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.1 | - | 0.0 | |||
CALCR | CT | Calcitonin | B1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 2 | 3 | 1 | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CALCR | CT | Calcitonin | B1 | - | GproteinDb | merged data | - | - | - | - | - | 3 | 2 | 3 | 1 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 48 | 60 | 46 | - | - | - | - | - | GsL | 100 | - | - | 68 | 68 | - | - | 63 | 45 | 74 | 34 | 62 | 67 | 60 | 72 | 46 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CALRL | Calcitonin -like | Calcitonin | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | amylin | Phys | 1 | - | - | - | Gs | 1 | 1' | nc | 2' | nc | 100 | 0 | 6 | 0 | Activation rate (s-1) | 0.7 | 0.0 | 0.0 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 6 | - | 0 | Activation rate (s-1) | 0.7 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
CALRL | Calcitonin -like | Calcitonin | B1 | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | - | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 6 | 0 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 6 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | - | Bouvier | GEMTA | 3 | 12 | urocortin 2 | Phys | 3 | 2 | 3 | 2 | G12/13 | 4 | 2' | 3' | 4' | 1' | 87 | 75 | 73 | 100 | log(Emax/EC50) | 7.4 | 6.4 | 6.2 | 8.5 | G13 | 87 | - | - | 73 | 72 | - | - | 70 | 0 | 75 | 0 | 0 | 0 | 73 | 92 | 100 | log(Emax/EC50) | 7.4 | - | - | 6.2 | 6.2 | - | - | 5.9 | 0.0 | 6.4 | 0.0 | 0.0 | 0.0 | 6.2 | 7.8 | 8.5 | |||
CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | Corticoliberin | Phys | 3 | 2 | 3 | 2 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 9 | 9 | 2 | Activation rate (s-1) | 4.1 | 0.4 | 0.4 | 0.1 | GsL | 100 | - | - | - | - | - | - | - | 9 | - | 0 | - | - | 9 | - | 2 | Activation rate (s-1) | 4.1 | - | - | - | - | - | - | - | 0.4 | - | 0.0 | - | - | 0.4 | - | 0.1 | |||
CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | 3 | 2 | 3 | 2 | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
CRFR1 | CRF1 | Corticotropin-releasing factor | B1 | - | GproteinDb | merged data | - | - | - | - | - | 3 | 2 | 3 | 2 | Gs | 4 | 1' | 3' | 4' | 2' | 94 | 42 | 41 | 51 | - | - | - | - | - | GsL | 94 | - | - | 73 | 72 | - | - | 70 | 4 | 75 | 0 | 0 | 0 | 41 | 92 | 51 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CRFR2 | CRF2 | Corticotropin-releasing factor | B1 | - | Bouvier | GEMTA | 3 | 12 | urocortin 2 | Phys | 3 | 2 | 3 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 77 | 84 | 0 | log(Emax/EC50) | 10.3 | 7.9 | 8.6 | 0.0 | GsL | 100 | - | - | 77 | 74 | - | - | 69 | 73 | 76 | 0 | 0 | 57 | 84 | 0 | 0 | log(Emax/EC50) | 10.3 | - | - | 7.9 | 7.6 | - | - | 7.1 | 7.6 | 7.8 | 0.0 | 0.0 | 5.8 | 8.6 | 0.0 | 0.0 | |||
CRFR2 | CRF2 | Corticotropin-releasing factor | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | Corticoliberin | Phys | 3 | 2 | 3 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 13 | 14 | 0 | Activation rate (s-1) | 1.7 | 0.2 | 0.2 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 13 | - | 0 | - | - | 14 | - | 0 | Activation rate (s-1) | 1.7 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.2 | - | 0.0 | |||
CRFR2 | CRF2 | Corticotropin-releasing factor | B1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | 3 | 2 | 3 | - | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
CRFR2 | CRF2 | Corticotropin-releasing factor | B1 | - | GproteinDb | merged data | - | - | - | - | - | 3 | 2 | 3 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 45 | 49 | 0 | - | - | - | - | - | GsL | 100 | - | - | 77 | 74 | - | - | 69 | 43 | 76 | 0 | 0 | 57 | 49 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GHRHR | GHRH | Glucagon | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | GHRH | Phys | 1 | - | - | - | Gs | 0 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.0 | 0.0 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
GHRHR | GHRH | Glucagon | B1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GHRHR | GHRH | Glucagon | B1 | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GIPR | GIP | Glucagon | B1 | - | Bouvier | GEMTA | 3 | 12 | gastric inhibitory polypeptide | Phys | 3 | 2 | 1 | - | Gs | 3 | 1' | 3' | 2' | nc | 100 | 84 | 85 | 0 | log(Emax/EC50) | 10.4 | 8.7 | 8.8 | 0.0 | GsL | 100 | - | - | 79 | 81 | - | - | 81 | 79 | 84 | 0 | 0 | 62 | 85 | 0 | 0 | log(Emax/EC50) | 10.4 | - | - | 8.2 | 8.4 | - | - | 8.4 | 8.2 | 8.7 | 0.0 | 0.0 | 6.4 | 8.8 | 0.0 | 0.0 | |||
GIPR | GIP | Glucagon | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | gastric inhibitory polypeptide | Phys | 3 | 2 | 1 | - | Gs | 2 | 1' | 2' | 3' | nc | 100 | 22 | 4 | 0 | Activation rate (s-1) | 0.6 | 0.1 | 0.0 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 22 | - | 0 | - | - | 4 | - | 0 | Activation rate (s-1) | 0.6 | - | - | - | - | - | - | - | 0.1 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
GIPR | GIP | Glucagon | B1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 2 | 1 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GIPR | GIP | Glucagon | B1 | - | GproteinDb | merged data | - | - | - | - | - | 3 | 2 | 1 | - | Gs | 3 | 1' | 2' | 3' | nc | 100 | 53 | 44 | 0 | - | - | - | - | - | GsL | 100 | - | - | 79 | 81 | - | - | 81 | 50 | 84 | 0 | 0 | 62 | 44 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GLP1R | GLP-1 | Glucagon | B1 | - | Bouvier | GEMTA | 3 | 12 | glucagon-like peptide 1-(7-37) | Phys | 3 | 2 | 2 | 1 | Gs | 4 | 1' | 2' | 3' | 4' | 100 | 82 | 78 | 71 | log(Emax/EC50) | 10.6 | 8.7 | 8.2 | 7.6 | GsL | 100 | - | - | 67 | 64 | - | - | 82 | 71 | 77 | 0 | 0 | 0 | 78 | 0 | 71 | log(Emax/EC50) | 10.6 | - | - | 7.0 | 6.7 | - | - | 8.7 | 7.5 | 8.1 | 0.0 | 0.0 | 0.0 | 8.2 | 0.0 | 7.6 | |||
GLP1R | GLP-1 | Glucagon | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | CHEMBL410972 | Phys | 3 | 2 | 2 | 1 | Gs | 3 | 1' | 2' | 3' | nc | 100 | 17 | 4 | 0 | Activation rate (s-1) | 1.4 | 0.2 | 0.1 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 17 | - | 0 | - | - | 4 | - | 0 | Activation rate (s-1) | 1.4 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.1 | - | 0.0 | |||
GLP1R | GLP-1 | Glucagon | B1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 2 | 2 | 1 | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GLP1R | GLP-1 | Glucagon | B1 | - | GproteinDb | merged data | - | - | - | - | - | 3 | 2 | 2 | 1 | Gs | 4 | 1' | 2' | 3' | 4' | 100 | 50 | 41 | 36 | - | - | - | - | - | GsL | 100 | - | - | 67 | 64 | - | - | 82 | 44 | 77 | 0 | 0 | 0 | 41 | 0 | 36 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GLP2R | GLP-2 | Glucagon | B1 | - | Bouvier | GEMTA | 3 | 12 | glucagon-like peptide 2 | Phys | 3 | 2 | 1 | - | Gs | 3 | 1' | 2' | 3' | nc | 100 | 85 | 75 | 0 | log(Emax/EC50) | 10.1 | 8.5 | 7.6 | 0.0 | GsL | 100 | - | - | 77 | 73 | - | - | 77 | 84 | 85 | 0 | 0 | 0 | 75 | 0 | 0 | log(Emax/EC50) | 10.1 | - | - | 7.8 | 7.3 | - | - | 7.7 | 8.4 | 8.5 | 0.0 | 0.0 | 0.0 | 7.6 | 0.0 | 0.0 | |||
GLP2R | GLP-2 | Glucagon | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | glucagon-like peptide 2 | Phys | 3 | 2 | 1 | - | Gs | 2 | 1' | 2' | 3' | nc | 100 | 86 | 4 | 0 | Activation rate (s-1) | 0.6 | 0.5 | 0.0 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 86 | - | 0 | - | - | 4 | - | 0 | Activation rate (s-1) | 0.6 | - | - | - | - | - | - | - | 0.5 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
GLP2R | GLP-2 | Glucagon | B1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 2 | 1 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GLP2R | GLP-2 | Glucagon | B1 | - | GproteinDb | merged data | - | - | - | - | - | 3 | 2 | 1 | - | Gs | 3 | 1' | 2' | 3' | nc | 100 | 86 | 40 | 0 | - | - | - | - | - | GsL | 100 | - | - | 77 | 73 | - | - | 77 | 85 | 85 | 0 | 0 | 0 | 40 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GLR | Glucagon | Glucagon | B1 | - | Bouvier | GEMTA | 3 | 12 | glucagon | Phys | 3 | 2 | 2 | 1 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 79 | 81 | 66 | log(Emax/EC50) | 11.0 | 8.6 | 8.9 | 7.2 | GsL | 100 | - | - | 73 | 70 | - | - | 72 | 75 | 79 | 57 | 56 | 56 | 81 | 0 | 66 | log(Emax/EC50) | 11.0 | - | - | 7.9 | 7.6 | - | - | 7.9 | 8.2 | 8.6 | 6.2 | 6.2 | 6.2 | 8.9 | 0.0 | 7.2 | |||
GLR | Glucagon | Glucagon | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | glucagon | Phys | 3 | 2 | 2 | 1 | Gs | 3 | 1' | 2' | 3' | nc | 100 | 39 | 8 | 0 | Activation rate (s-1) | 3.6 | 1.4 | 0.3 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 39 | - | 3 | - | - | 8 | - | 0 | Activation rate (s-1) | 3.6 | - | - | - | - | - | - | - | 1.4 | - | 0.1 | - | - | 0.3 | - | 0.0 | |||
GLR | Glucagon | Glucagon | B1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 2 | 2 | 1 | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GLR | Glucagon | Glucagon | B1 | - | GproteinDb | merged data | - | - | - | - | - | 3 | 2 | 2 | 1 | Gs | 4 | 1' | 2' | 3' | 4' | 100 | 59 | 44 | 33 | - | - | - | - | - | GsL | 100 | - | - | 73 | 70 | - | - | 72 | 57 | 79 | 30 | 56 | 56 | 44 | 0 | 33 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SCTR | Secretin | Glucagon | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | secretin | Phys | 2 | 1 | 1 | - | Gs | 3 | 1' | 2' | 3' | nc | 100 | 7 | 6 | 0 | Activation rate (s-1) | 2.8 | 0.2 | 0.2 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 7 | - | 5 | - | - | 6 | - | 0 | Activation rate (s-1) | 2.8 | - | - | - | - | - | - | - | 0.2 | - | 0.1 | - | - | 0.2 | - | 0.0 | |||
SCTR | Secretin | Glucagon | B1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | 1 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SCTR | Secretin | Glucagon | B1 | - | GproteinDb | merged data | - | - | - | - | - | 2 | 1 | 1 | - | Gs | 3 | 1' | 2' | 3' | nc | 100 | 7 | 6 | 0 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 7 | - | 5 | - | - | 6 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PTH1R | PTH1 | Parathyroid hormone | B1 | - | Bouvier | GEMTA | 3 | 12 | teriparatide | Phys | 3 | 2 | 4 | 2 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 71 | 82 | 68 | log(Emax/EC50) | 11.0 | 7.8 | 9.0 | 7.4 | GsL | 100 | - | - | 69 | 66 | - | - | 57 | 67 | 71 | 71 | 65 | 63 | 82 | 55 | 68 | log(Emax/EC50) | 11.0 | - | - | 7.6 | 7.2 | - | - | 6.3 | 7.4 | 7.8 | 7.8 | 7.1 | 7.0 | 9.0 | 6.0 | 7.4 | |||
PTH1R | PTH1 | Parathyroid hormone | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | teriparatide | Phys | 3 | 2 | 4 | 2 | Gs | 4 | 1' | 2' | 3' | 4' | 100 | 23 | 11 | 3 | Activation rate (s-1) | 2.1 | 0.5 | 0.2 | 0.1 | GsL | 100 | - | - | - | - | - | - | - | 23 | - | 5 | - | - | 11 | - | 3 | Activation rate (s-1) | 2.1 | - | - | - | - | - | - | - | 0.5 | - | 0.1 | - | - | 0.2 | - | 0.1 | |||
PTH1R | PTH1 | Parathyroid hormone | B1 | - | Inoue | TGF𝛼 | 5 | 1 | teriparatide | Phys | 3 | 2 | 4 | 2 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 7.1 | - | - | - | - | - | |||
PTH1R | PTH1 | Parathyroid hormone | B1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | 3 | 2 | 4 | 2 | Gs | 2 | 1' | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
PTH1R | PTH1 | Parathyroid hormone | B1 | - | GproteinDb | merged data | - | - | - | - | - | 3 | 2 | 4 | 2 | Gs | 4 | 1' | 2' | 3' | 4' | 100 | 47 | 46 | 36 | - | - | - | - | - | GsL | 100 | - | - | 69 | 66 | - | - | 57 | 45 | 71 | 38 | 65 | 63 | 46 | 55 | 36 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PTH2R | PTH2 | Parathyroid hormone | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | teriparatide | Phys | 1 | - | 2 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 12 | 0 | Activation rate (s-1) | 0.6 | 0.0 | 0.1 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 12 | - | 0 | Activation rate (s-1) | 0.6 | - | - | - | - | - | - | - | 0.0 | - | 0.0 | - | - | 0.1 | - | 0.0 | |||
PTH2R | PTH2 | Parathyroid hormone | B1 | - | Inoue | TGF𝛼 | 5 | 1 | TIP39 | Phys | 1 | - | 2 | - | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.1 | - | - | - | - | - | |||
PTH2R | PTH2 | Parathyroid hormone | B1 | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | 2 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 12 | 0 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 0 | - | - | 12 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PACR | PAC1 | VIP and PACAP | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | VIP | Phys | 2 | 1 | 3 | 1 | Gs | 4 | 1' | 4' | 2' | 3' | 100 | 4 | 69 | 8 | Activation rate (s-1) | 2.0 | 0.1 | 1.3 | 0.2 | GsL | 100 | - | - | - | - | - | - | - | 4 | - | 19 | - | - | 69 | - | 8 | Activation rate (s-1) | 2.0 | - | - | - | - | - | - | - | 0.1 | - | 0.4 | - | - | 1.3 | - | 0.2 | |||
PACR | PAC1 | VIP and PACAP | B1 | - | Inoue | TGF𝛼 | 5 | 1 | PACAP-27 | Phys | 2 | 1 | 3 | 1 | - | 1 | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | log(Emax/EC50) | - | - | - | - | - | - | - | - | - | - | 8.1 | - | - | - | - | - | |||
PACR | PAC1 | VIP and PACAP | B1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | 1 | 3 | 1 | Gs | 2 | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
PACR | PAC1 | VIP and PACAP | B1 | - | GproteinDb | merged data | - | - | - | - | - | 2 | 1 | 3 | 1 | Gs | 4 | 1' | 4' | 2' | 3' | 100 | 4 | 69 | 8 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 4 | - | 19 | - | - | 69 | - | 8 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
VIPR1 | VPAC1 | VIP and PACAP | B1 | - | Bouvier | GEMTA | 3 | 12 | VIP | Phys | 3 | 3 | 3 | 2 | Gs | 4 | 1' | 4' | 2' | 3' | 100 | 71 | 85 | 72 | log(Emax/EC50) | 11.2 | 8.0 | 9.5 | 8.1 | GsL | 100 | - | - | 67 | 68 | - | - | 64 | 64 | 71 | 71 | 65 | 58 | 85 | 66 | 72 | log(Emax/EC50) | 11.2 | - | - | 7.6 | 7.6 | - | - | 7.2 | 7.2 | 8.0 | 7.9 | 7.3 | 6.5 | 9.5 | 7.4 | 8.1 | |||
VIPR1 | VPAC1 | VIP and PACAP | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | VIP | Phys | 3 | 3 | 3 | 2 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 5 | 11 | 2 | Activation rate (s-1) | 4.0 | 0.2 | 0.4 | 0.1 | GsL | 100 | - | - | - | - | - | - | - | 5 | - | 2 | - | - | 11 | - | 2 | Activation rate (s-1) | 4.0 | - | - | - | - | - | - | - | 0.2 | - | 0.1 | - | - | 0.4 | - | 0.1 | |||
VIPR1 | VPAC1 | VIP and PACAP | B1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | 3 | 3 | 2 | Gs | 3 | 1' | 2' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
VIPR1 | VPAC1 | VIP and PACAP | B1 | - | GproteinDb | merged data | - | - | - | - | - | 3 | 3 | 3 | 2 | Gs | 4 | 1' | 3' | 2' | 4' | 100 | 38 | 48 | 37 | - | - | - | - | - | GsL | 100 | - | - | 67 | 68 | - | - | 64 | 34 | 71 | 36 | 65 | 58 | 48 | 66 | 37 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
VIPR2 | VPAC2 | VIP and PACAP | B1 | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | VIP | Phys | 2 | - | 1 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 10 | 0 | Activation rate (s-1) | 3.3 | 0.0 | 0.3 | 0.0 | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 10 | - | - | 3 | - | 0 | Activation rate (s-1) | 3.3 | - | - | - | - | - | - | - | 0.0 | - | 0.3 | - | - | 0.1 | - | 0.0 | |||
VIPR2 | VPAC2 | VIP and PACAP | B1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | 1 | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
VIPR2 | VPAC2 | VIP and PACAP | B1 | - | GproteinDb | merged data | - | - | - | - | - | 2 | - | 1 | - | Gs | 2 | 1' | nc | 2' | nc | 100 | 0 | 10 | 0 | - | - | - | - | - | GsL | 100 | - | - | - | - | - | - | - | 0 | - | 10 | - | - | 3 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRL1 | ADGRL1 | ADGRL | B2 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
AGRL1 | ADGRL1 | ADGRL | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRE2 | ADGRE2 | ADGRE | B2 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
AGRE2 | ADGRE2 | ADGRE | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRE5 | ADGRE5 | ADGRE | B2 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | - | 1 | G12/13 | 1 | - | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRE5 | ADGRE5 | ADGRE | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | 1 | G12/13 | 1 | - | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRA2 | ADGRA2 | ADGRA | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Efficacy | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | 0.00 | 0.00 | ||
AGRA2 | ADGRA2 | ADGRA | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRA3 | ADGRA3 | ADGRA | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Efficacy | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | 0.00 | 0.00 | ||
AGRA3 | ADGRA3 | ADGRA | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRD1 | ADGRD1 | ADGRD | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | 1 | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Efficacy | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | 0.00 | 0.00 | ||
AGRD1 | ADGRD1 | ADGRD | B2 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRD1 | ADGRD1 | ADGRD | B2 | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRD2 | ADGRD2 | ADGRD | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Efficacy | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | 0.00 | 0.00 | ||
AGRD2 | ADGRD2 | ADGRD | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRF1 | ADGRF1 | ADGRF | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | 1 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Efficacy | 0.00 | 0.01 | 0.00 | 0.00 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | Efficacy | 0.00 | - | - | 0.01 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | 0.00 | 0.00 | ||
AGRF1 | ADGRF1 | ADGRF | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRF2 | ADGRF2 | ADGRF | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | 1 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 95 | 64 | Efficacy | 0.00 | 0.04 | 0.04 | 0.02 | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 92 | - | - | 95 | 48 | 64 | Efficacy | 0.00 | - | - | 0.04 | - | - | - | - | - | - | 0.04 | - | - | 0.04 | 0.02 | 0.02 | ||
AGRF2 | ADGRF2 | ADGRF | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | 1 | Gi/o | 3 | nc | 1' | 2' | 3' | 0 | 100 | 95 | 64 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | - | - | - | - | - | - | 92 | - | - | 95 | 48 | 64 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRF3 | ADGRF3 | ADGRF | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Efficacy | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | 0.00 | 0.00 | ||
AGRF3 | ADGRF3 | ADGRF | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRF4 | ADGRF4 | ADGRF | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Efficacy | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | 0.00 | 0.00 | ||
AGRF4 | ADGRF4 | ADGRF | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRF5 | ADGRF5 | ADGRF | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Efficacy | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | 0.00 | 0.00 | ||
AGRF5 | ADGRF5 | ADGRF | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRG1 | ADGRG1 | ADGRG | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | - | 1 | 2 | G12/13 | 1 | nc | nc | nc | 1' | 0 | 0 | 0 | 100 | Efficacy | 0.00 | 0.00 | 0.00 | 0.01 | G12 | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 100 | 0 | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | 0.01 | 0.00 | ||
AGRG1 | ADGRG1 | ADGRG | B2 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 1 | 2 | Gq/11 | 2 | - | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRG1 | ADGRG1 | ADGRG | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | 2 | G12/13 | 1 | nc | nc | nc | 1' | 0 | 0 | 0 | 100 | - | - | - | - | - | G12 | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 100 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRG2 | ADGRG2 | ADGRG | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | - | 1 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Efficacy | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | 0.00 | 0.00 | ||
AGRG2 | ADGRG2 | ADGRG | B2 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | 1 | - | - | 1 | - | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRG2 | ADGRG2 | ADGRG | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRG3 | ADGRG3 | ADGRG | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | 1 | - | 1 | G12/13 | 1 | nc | nc | nc | 1' | 0 | 0 | 0 | 100 | Efficacy | 0.00 | 0.00 | 0.00 | 0.03 | G13 | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 52 | 100 | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | 0.01 | 0.03 | ||
AGRG3 | ADGRG3 | ADGRG | B2 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | 1 | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
AGRG3 | ADGRG3 | ADGRG | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | 1 | G12/13 | 1 | nc | nc | nc | 1' | 0 | 0 | 0 | 100 | - | - | - | - | - | G13 | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 52 | 100 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRG5 | ADGRG5 | ADGRG | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Efficacy | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | Efficacy | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | 0.00 | 0.00 | ||
AGRG5 | ADGRG5 | ADGRG | B2 | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
AGRG6 | ADGRG6 | ADGRG | B2 | - | Lambert | RGB-GDP | 0 | 6 | - | None (constitutive activity) | - | 1 | - | - | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | Efficacy | 0.01 | 0.00 | 0.00 | 0.00 | GsL | 100 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | Efficacy | 0.01 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | 0.00 | 0.00 | ||
AGRG6 | ADGRG6 | ADGRG | B2 | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | nc | nc | nc | 100 | 0 | 0 | 0 | - | - | - | - | - | GsL | 100 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CASR | CaS | Calcium-sensing | C | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 1 | 1 | Gi/o | 3 | - | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CASR | CaS | Calcium-sensing | C | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | 1 | Gi/o | 3 | - | 1' | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRM1 | mGlu1 | Metabotropic glutamate | C | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | L-glutamic acid | Phys | 1 | 2 | 2 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 85 | 100 | 0 | Activation rate (s-1) | 0.0 | 0.6 | 0.7 | 0.0 | Gq | 0 | - | - | - | - | - | - | - | 85 | - | 100 | - | - | 7 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.6 | - | 0.7 | - | - | 0.0 | - | 0.0 | |||
GRM1 | mGlu1 | Metabotropic glutamate | C | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 2 | 2 | - | Gq/11 | 3 | 2' | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRM1 | mGlu1 | Metabotropic glutamate | C | - | GproteinDb | merged data | - | - | - | - | - | 1 | 2 | 2 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 85 | 100 | 0 | - | - | - | - | - | Gq | 0 | - | - | - | - | - | - | - | 85 | - | 100 | - | - | 7 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRM2 | mGlu2 | Metabotropic glutamate | C | - | Bouvier | GEMTA | 3 | 12 | L-glutamic acid | Phys | - | 3 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 94 | 0 | log(Emax/EC50) | 0.0 | 5.1 | 4.8 | 0.0 | Gi1 | 0 | - | - | 100 | 91 | - | - | 84 | 98 | 99 | 0 | 0 | 0 | 94 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 5.1 | 4.6 | - | - | 4.3 | 5.0 | 5.0 | 0.0 | 0.0 | 0.0 | 4.8 | 0.0 | 0.0 | |||
GRM2 | mGlu2 | Metabotropic glutamate | C | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | L-glutamic acid | Phys | - | 3 | 1 | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 1 | 0 | Activation rate (s-1) | 0.0 | 5.9 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 1 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 5.9 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
GRM2 | mGlu2 | Metabotropic glutamate | C | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | 1 | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRM2 | mGlu2 | Metabotropic glutamate | C | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | 1 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 48 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 91 | - | - | 84 | 99 | 99 | 0 | 0 | 0 | 48 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRM3 | mGlu3 | Metabotropic glutamate | C | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | L-glutamic acid | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | Activation rate (s-1) | 0.0 | 0.6 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.6 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
GRM3 | mGlu3 | Metabotropic glutamate | C | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRM3 | mGlu3 | Metabotropic glutamate | C | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 2 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 2 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRM4 | mGlu4 | Metabotropic glutamate | C | - | Bouvier | GEMTA | 3 | 12 | L-glutamic acid | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 4.1 | 0.0 | 0.0 | GoA | 0 | - | - | 87 | 0 | - | - | 0 | 100 | 98 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 3.6 | 0.0 | - | - | 0.0 | 4.1 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
GRM4 | mGlu4 | Metabotropic glutamate | C | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | L-glutamic acid | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.7 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.7 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
GRM4 | mGlu4 | Metabotropic glutamate | C | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRM4 | mGlu4 | Metabotropic glutamate | C | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | 87 | 0 | - | - | 0 | 100 | 98 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRM5 | mGlu5 | Metabotropic glutamate | C | - | Bouvier | GEMTA | 3 | 12 | L-glutamic acid | Phys | 1 | 3 | 3 | - | Gq/11 | 2 | nc | 2' | 1' | nc | 0 | 91 | 100 | 0 | log(Emax/EC50) | 0.0 | 5.3 | 5.8 | 0.0 | G15 | 0 | - | - | 91 | 86 | - | - | 81 | 86 | 84 | 95 | 96 | 84 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 5.3 | 5.0 | - | - | 4.7 | 5.0 | 4.9 | 5.5 | 5.6 | 4.9 | 5.8 | 0.0 | 0.0 | |||
GRM5 | mGlu5 | Metabotropic glutamate | C | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | L-glutamic acid | Phys | 1 | 3 | 3 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 100 | 41 | 0 | Activation rate (s-1) | 0.0 | 0.8 | 0.3 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 41 | - | - | 9 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.8 | - | 0.3 | - | - | 0.1 | - | 0.0 | |||
GRM5 | mGlu5 | Metabotropic glutamate | C | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 3 | 3 | - | Gq/11 | 3 | 2' | 2' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRM5 | mGlu5 | Metabotropic glutamate | C | - | GproteinDb | merged data | - | - | - | - | - | 1 | 3 | 3 | - | Gi/o | 2 | nc | 1' | 2' | nc | 0 | 96 | 70 | 0 | - | - | - | - | - | G11 | 0 | - | - | 91 | 86 | - | - | 81 | 93 | 84 | 68 | 96 | 84 | 54 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRM6 | mGlu6 | Metabotropic glutamate | C | - | Bouvier | GEMTA | 3 | 12 | L-glutamic acid | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 4.5 | 0.0 | 0.0 | GoB | 0 | - | - | 94 | 86 | - | - | 81 | 96 | 100 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 4.2 | 3.8 | - | - | 3.6 | 4.3 | 4.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
GRM6 | mGlu6 | Metabotropic glutamate | C | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | L-glutamic acid | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 2.5 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 2.5 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
GRM6 | mGlu6 | Metabotropic glutamate | C | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GRM6 | mGlu6 | Metabotropic glutamate | C | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoB | 0 | - | - | 94 | 86 | - | - | 81 | 98 | 100 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRM7 | mGlu7 | Metabotropic glutamate | C | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | L-glutamic acid | Phys | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.2 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.2 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
GRM7 | mGlu7 | Metabotropic glutamate | C | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 2 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GRM7 | mGlu7 | Metabotropic glutamate | C | - | GproteinDb | merged data | - | - | - | - | - | - | 2 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GRM8 | mGlu8 | Metabotropic glutamate | C | - | Bouvier | GEMTA | 3 | 12 | L-glutamic acid | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | log(Emax/EC50) | 0.0 | 5.3 | 0.0 | 0.0 | Gi1 | 0 | - | - | 100 | 92 | - | - | 88 | 94 | 94 | 0 | 0 | 0 | 0 | 0 | 0 | log(Emax/EC50) | 0.0 | - | - | 5.3 | 4.8 | - | - | 4.6 | 5.0 | 5.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
GRM8 | mGlu8 | Metabotropic glutamate | C | - | Martemyanov | FreeGβγ-Nluc | 2 | 5 | L-glutamic acid | Phys | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | Activation rate (s-1) | 0.0 | 0.3 | 0.0 | 0.0 | GoA | 0 | - | - | - | - | - | - | - | 100 | - | 0 | - | - | 0 | - | 0 | Activation rate (s-1) | 0.0 | - | - | - | - | - | - | - | 0.3 | - | 0.0 | - | - | 0.0 | - | 0.0 | |||
GRM8 | mGlu8 | Metabotropic glutamate | C | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 3 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GRM8 | mGlu8 | Metabotropic glutamate | C | - | GproteinDb | merged data | - | - | - | - | - | - | 3 | - | - | Gi/o | 1 | nc | 1' | nc | nc | 0 | 100 | 0 | 0 | - | - | - | - | - | Gi1 | 0 | - | - | 100 | 92 | - | - | 88 | 97 | 94 | 0 | 0 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD2 | FZD2 | Frizzled | F | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD2 | FZD2 | Frizzled | F | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GPC6A | GPRC6 | C Orphans | C | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||
GPC6A | GPRC6 | C Orphans | C | - | GproteinDb | merged data | - | - | - | - | - | - | - | 1 | - | Gq/11 | 1 | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
STE2 | STE2 | STE2 | D1 | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | - | - | GPa1 family | 1 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
STE2 | STE2 | STE2 | D1 | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | GPa1 family | 1 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD1 | FZD1 | Frizzled | F | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 1 | - | - | 2 | - | 2' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD1 | FZD1 | Frizzled | F | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | - | 2 | - | 2' | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD3 | FZD3 | Frizzled | F | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD3 | FZD3 | Frizzled | F | - | GproteinDb | merged data | - | - | - | - | - | 1 | - | - | - | Gs | 1 | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD4 | FZD4 | Frizzled | F | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | - | 1 | G12/13 | 1 | - | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD4 | FZD4 | Frizzled | F | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | 1 | G12/13 | 1 | - | - | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD6 | FZD6 | Frizzled | F | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD6 | FZD6 | Frizzled | F | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | 1 | - | Gi/o | 2 | - | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD7 | FZD7 | Frizzled | F | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | 1 | 1 | - | - | Gs | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD7 | FZD7 | Frizzled | F | - | GproteinDb | merged data | - | - | - | - | - | 1 | 1 | - | - | Gs | 2 | 1' | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD9 | FZD9 | Frizzled | F | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD9 | FZD9 | Frizzled | F | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | - | Gi/o | 1 | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD10 | FZD10 | Frizzled | F | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | - | - | 1 | - | 1 | - | - | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
FZD10 | FZD10 | Frizzled | F | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | 1 | - | 1 | - | - | - | 2' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SMO | SMO | Frizzled | F | - | GtoPdb | - (annotated from literature) | - | - | - | - | - | - | 1 | - | 1 | Gi/o | 2 | - | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
SMO | SMO | Frizzled | F | - | GproteinDb | merged data | - | - | - | - | - | - | 1 | - | 1 | Gi/o | 2 | - | 1' | - | 1' | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
GP157 | GPR157 | Other GPCR orphans | O | - | Lambert | RGB-GDP | 0 | 6 | None (constitutive activity) | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | Econstitutive | 0.00 | 0.00 | 0.00 | 0.00 | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | Econstitutive | 0.00 | - | - | 0.00 | - | - | - | - | - | - | 0.00 | - | - | 0.00 | - | 0.00 | |||
GP157 | GPR157 | Other GPCR orphans | O | - | GproteinDb | merged data | - | - | - | - | - | - | - | - | - | - | 0 | nc | nc | nc | nc | 0 | 0 | 0 | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | - | - | - | - | - | 0 | - | - | 0 | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||
CALCR | CT | Calcitonin | B1 | RAMP3 | Bouvier | GEMTA | 3 | 12 | amylin | Phys | 1 | - | 1 | 1 | G12/13 | 3 | 2' | nc | 3' | 1' | 90 | 0 | 78 | 100 | log(Emax/EC50) | 7.3 | 0.0 | 6.3 | 8.1 | G13 | 90 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 0 | 0 | 0 | 78 | 93 | 100 | log(Emax/EC50) | 7.3 | - | - | 0.0 | 0.0 | - | - | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.3 | 7.5 | 8.1 | |||
CALCR | CT | Calcitonin | B1 | RAMP3 | GproteinDb | merged data | - | - | - | - | - | 1 | - | 1 | 1 | G12/13 | 3 | 2' | nc | 3' | 1' | 90 | 0 | 78 | 100 | - | - | - | - | - | G13 | 90 | - | - | 0 | 0 | - | - | 0 | 0 | 0 | 0 | 0 | 0 | 78 | 93 | 100 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |