CRF2 receptor (crfr2_human)
FAMILY
Class B1 (Secretin) Peptide receptors Corticotropin-releasing factor receptors CRF2 receptor
GENE
CRHR2 (CRF2R, CRH2R)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Corticotropin-releasing factor receptor 2, CRF-R-2, CRF-R2, CRFR-2, Corticotropin-releasing hormone receptor 2, CRH-R-2, CRH-R2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
A
|
A
|
L
|
L
|
H
|
S
|
L
|
L
|
10 |
E
|
A
|
N
|
C
|
S
|
L
|
A
|
L
|
A
|
E
|
20 |
E
|
L
|
L
|
L
|
D
|
G
|
W
|
G
|
P
|
P
|
30 |
L
|
D
|
P
|
E
|
G
|
P
|
Y
|
S
|
Y
|
C
|
40 |
N
|
T
|
T
|
L
|
D
|
Q
|
I
|
G
|
T
|
C
|
50 |
W
|
P
|
R
|
S
|
A
|
A
|
G
|
A
|
L
|
V
|
60 |
E
|
R
|
P
|
C
|
P
|
E
|
Y
|
F
|
N
|
G
|
70 |
V
|
K
|
Y
|
N
|
T
|
T
|
R
|
N
|
A
|
Y
|
80 |
R
|
E
|
C
|
L
|
E
|
N
|
G
|
T
|
W
|
A
|
90 |
S
|
K
|
I
|
N
|
Y
|
S
|
Q
|
C
|
E
|
P
|
100 |
TM1 | |||||||||
I
|
L
|
D
|
D
|
K
|
Q
|
R
|
K
|
Y
|
D
|
110 |
L
|
H
|
Y
|
R
|
I
|
A
|
L
|
V
|
V
|
N
|
120 |
Y
|
L
|
G
|
H
|
C
|
V
|
S
|
V
|
A
|
A
|
130 |
L
|
V
|
A
|
A
|
F
|
L
|
L
|
F
|
L
|
A
|
140 |
ICL1 | TM2 | ||||||||
L
|
R
|
S
|
I
|
R
|
C
|
L
|
R
|
N
|
V
|
150 |
I
|
H
|
W
|
N
|
L
|
I
|
T
|
T
|
F
|
I
|
160 |
L
|
R
|
N
|
V
|
M
|
W
|
F
|
L
|
L
|
Q
|
170 |
ECL1 | |||||||||
L
|
V
|
D
|
H
|
E
|
V
|
H
|
E
|
S
|
N
|
180 |
TM3 | |||||||||
E
|
V
|
W
|
C
|
R
|
C
|
I
|
T
|
T
|
I
|
190 |
F
|
N
|
Y
|
F
|
V
|
V
|
T
|
N
|
F
|
F
|
200 |
W
|
M
|
F
|
V
|
E
|
G
|
C
|
Y
|
L
|
H
|
210 |
ICL2 | |||||||||
T
|
A
|
I
|
V
|
M
|
T
|
Y
|
S
|
T
|
E
|
220 |
TM4 | |||||||||
R
|
L
|
R
|
K
|
C
|
L
|
F
|
L
|
F
|
I
|
230 |
G
|
W
|
C
|
I
|
P
|
F
|
P
|
I
|
I
|
V
|
240 |
A
|
W
|
A
|
I
|
G
|
K
|
L
|
Y
|
Y
|
E
|
250 |
ECL2 | |||||||||
N
|
E
|
Q
|
C
|
W
|
F
|
G
|
K
|
E
|
P
|
260 |
TM5 | |||||||||
G
|
D
|
L
|
V
|
D
|
Y
|
I
|
Y
|
Q
|
G
|
270 |
P
|
I
|
I
|
L
|
V
|
L
|
L
|
I
|
N
|
F
|
280 |
V
|
F
|
L
|
F
|
N
|
I
|
V
|
R
|
I
|
L
|
290 |
ICL3 | |||||||||
M
|
T
|
K
|
L
|
R
|
A
|
S
|
T
|
T
|
S
|
300 |
TM6 | |||||||||
E
|
T
|
I
|
Q
|
Y
|
R
|
K
|
A
|
V
|
K
|
310 |
A
|
T
|
L
|
V
|
L
|
L
|
P
|
L
|
L
|
G
|
320 |
I
|
T
|
Y
|
M
|
L
|
F
|
F
|
V
|
N
|
P
|
330 |
ECL3 | TM7 | ||||||||
G
|
E
|
D
|
D
|
L
|
S
|
Q
|
I
|
M
|
F
|
340 |
I
|
Y
|
F
|
N
|
S
|
F
|
L
|
Q
|
S
|
F
|
350 |
Q
|
G
|
F
|
F
|
V
|
S
|
V
|
F
|
Y
|
C
|
360 |
H8 | |||||||||
F
|
F
|
N
|
G
|
E
|
V
|
R
|
S
|
A
|
V
|
370 |
R
|
K
|
R
|
W
|
H
|
R
|
W
|
Q
|
D
|
H
|
380 |
H
|
S
|
L
|
R
|
V
|
P
|
M
|
A
|
R
|
A
|
390 |
C-term | |||||||||
M
|
S
|
I
|
P
|
T
|
S
|
P
|
T
|
R
|
I
|
400 |
S
|
F
|
H
|
S
|
I
|
K
|
Q
|
T
|
A
|
A
|
410 |
V
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
urocortin 1, urocortin 2, corticotrophin-releasing hormone, urocortin 3
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page