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G PROTEIN
STRUCTURE
RECEPTOR
OTHER PROTEINS
STRUCTURE LIGAND
ENDOGENOUS LIGAND
REFERENCE
Fam. α Species Note % of Seq β Species γ Species Method
PDB
 Refined
structure
 Resolution
UniProt
 IUPHAR Receptor family Class Species Receptor fusion Antibodies Other Name Type Function Name Type Authors Reference PDB Date
GPa1 family αPa1 strain ATCC 204508 / S288c Two alpha subunits bound to STE2 dimer 46 STE4 strain ATCC 204508 / S288c γ strain ATCC 204508 / S288c cryo-EM 7AD3 - 3.5 STE2 STE2 STE2 D1 (Ste2-like fungal pheromone) strain ATCC 204508 / S288c - - Gpa1 Alpha-factor mating pheromone pubchem
peptide Agonist - - Velazhahan V, Ma N, Pandy-Szekeres G, Kooistra AJ, Lee Y, Gloriam DE, Vaidehi N, Tate CG 10.1038/S41586-020-2994-1 2020-12-09
Gi/o αo Human - 59 β1 Human γ2 Human cryo-EM 6G79 6G79_refined 3.8 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human - - - Donitriptan pubchem
small molecule Agonist 5-hydroxytryptamine, tryptamine, 5-HT-moduline small molecule None 10.1038/S41586-018-0241-9 2018-06-20
Gi/o αo Human - 60 β1 Mouse γ2 Human cryo-EM 6K41 - 2.9 ADA2B α2B Adrenoceptors A (Rhodopsin) Human T4-Lysozyme scFv - Dexmedetomidine pubchem
small molecule Agonist (-)-adrenaline, (-)-noradrenaline small molecule Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang HW, Kobilka BK 10.1038/S41589-020-0492-2 2020-04-15
Gi/o αi1 Human - 62 β1 Mouse γ2 Human cryo-EM 6K42 - 4.1 ADA2B α2B Adrenoceptors A (Rhodopsin) Human T4-Lysozyme scFv - Dexmedetomidine pubchem
small molecule Agonist (-)-adrenaline, (-)-noradrenaline small molecule Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang HW, Kobilka BK 10.1038/S41589-020-0492-2 2020-04-15
Gi/o αi1 Human - 65 β1 Human γ2 Human cryo-EM 6LFO 6LFO_refined 3.4 CXCR2 CXCR2 Chemokine A (Rhodopsin) Human - scFv16 - Interleukin-8 pubchem
protein Agonist CXCL6, CXCL8, CXCL1, CXCL2, CXCL3, CXCL5, CXCL7 protein Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ 10.1038/S41586-020-2492-5 2020-09-02
Gi/o αi1 Human - 65 β1 Human γ2 Human cryo-EM 6LFM 6LFM_refined 3.5 CXCR2 CXCR2 Chemokine A (Rhodopsin) Human - scFv16 - Interleukin-8 pubchem
protein Agonist CXCL6, CXCL8, CXCL1, CXCL2, CXCL3, CXCL5, CXCL7 protein Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ 10.1038/S41586-020-2492-5 2020-09-02
Gi/o αi1 Human Non-canonical conformation 62 β1 Human γ2 Human cryo-EM 6OSA 6OSA_refined 3.0 NTR1 NTS1 Neurotensin A (Rhodopsin) Human - - - JMV449 pubchem
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G 10.1038/S41586-019-1337-6 2019-07-10
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 6OS9 6OS9_refined 3.0 NTR1 NTS1 Neurotensin A (Rhodopsin) Human - scFv16 - JMV449 pubchem
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G 10.1038/S41586-019-1337-6 2019-07-10
Gi/o αi1 Human - 62 β1 Rat γ2 Bovine cryo-EM 7DB6 7DB6_refined 3.3 MTR1A MT1 Melatonin A (Rhodopsin) Human - scFv16 - Ramelteon pubchem chembl_ligand
small molecule Agonist melatonin small molecule Okamoto HH, Miyauchi H, Inoue A, Raimondi F, Tsujimoto H, Kusakizako T, Shihoya W, Yamashita K, Suno R, Nomura N, Kobayashi T, Iwata S, Nishizawa T, Nureki O 10.1038/S41594-021-00634-1 2021-08-18
Gs αs Bovine - 57 β1 Rat γ2 Bovine cryo-EM 6NBH - 3.5 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human - Nanobody-35 - Long-acting parathyroid hormone analog
peptide Agonist TIP39, PTHrP, PTH, PTHrP-(1-36) peptide Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y 10.1126/SCIENCE.AAV7942 2019-04-17
Gs αs Bovine - 58 β1 Rat γ2 Bovine cryo-EM 6NBF - 3.0 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human - Nanobody-35 - Long-acting parathyroid hormone analog
peptide Agonist TIP39, PTHrP, PTH, PTHrP-(1-36) peptide Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y 10.1126/SCIENCE.AAV7942 2019-04-17
Gs αs Bovine - 56 β1 Rat γ2 Bovine cryo-EM 6NBI 6NBI_refined 4.0 PTH1R PTH1 Parathyroid hormone B1 (Secretin) Human - Nanobody-35 - Long-acting parathyroid hormone analog
peptide Agonist TIP39, PTHrP, PTH, PTHrP-(1-36) peptide Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y 10.1126/SCIENCE.AAV7942 2019-04-17
Gs αs Bovine - 59 β1 Rat γ2 Bovine cryo-EM 7DTY 7DTY_refined 3.0 GIPR GIP Glucagon B1 (Secretin) Human - Nanobody-35 - GIP pubchem
peptide Agonist gastric inhibitory polypeptide peptide Zhao F, Zhang C, Zhou Q, Hang K, Zou X, Chen Y, Wu F, Rao Q, Dai A, Yin W, Shen DD, Zhang Y, Xia T, Stevens RC, Xu HE, Yang D, Zhao L, Wang MW 10.7554/ELIFE.68719 2021-08-04
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 7CX2 7CX2_refined 2.8 PE2R2 EP2 Prostanoid A (Rhodopsin) Human - Nanobody-35 - Prostaglandin E2 pubchem chembl_ligand
small molecule Agonist PGE1, PGD2, PGE2, PGF2α, PGI2 small molecule Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y 10.1126/SCIADV.ABF1268 2021-05-05
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 7CX3 7CX3_refined 2.8 PE2R2 EP2 Prostanoid A (Rhodopsin) Human - Nanobody-35 - Taprenepag pubchem chembl_ligand
small molecule Agonist PGE1, PGD2, PGE2, PGF2α, PGI2 small molecule Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y 10.1126/SCIADV.ABF1268 2021-05-05
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 7CX4 7CX4_refined 2.9 PE2R2 EP2 Prostanoid A (Rhodopsin) Human - Nanobody-35 - Evatanepag pubchem chembl_ligand
small molecule Agonist PGE1, PGD2, PGE2, PGF2α, PGI2 small molecule Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y 10.1126/SCIADV.ABF1268 2021-05-05
Gi/o αi1 Human - 58 β1 Human γ2 Human cryo-EM 7MTS 7MTS_refined 3.2 GRM2 mGlu2 Metabotropic glutamate C (Glutamate) Human - - - 2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine pubchem
Glutamic acid pubchem
small molecule
amino acid 		Ago-PAM
Agonist 		L-glutamic acid amino acid Seven AB, Barros-Alvarez X, de Lapeyriere M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G 10.1038/S41586-021-03680-3 2021-07-07
Gi/o αo Human - 59 β1 Rat γ2 Mouse cryo-EM 6WWZ 6WWZ_refined 3.3 CCR6 CCR6 Chemokine A (Rhodopsin) Human - scFv16 - CCL20
protein Agonist CCL20, beta-defensin 4A protein Wasilko DJ, Johnson ZL, Ammirati M, Che Y, Griffor MC, Han S, Wu H 10.1038/S41467-020-16820-6 2020-06-24
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 7JHJ 7JHJ_refined 3.2 Q3KSP2 BILF1 Unclassified A (Rhodopsin) strain GD1 - scFv16 - Apo (no ligand)
none Apo (no ligand) - - Tsutsumi N, Qu Q, Mavri M, Baggesen MS, Maeda S, Waghray D, Berg C, Kobilka BK, Rosenkilde MM, Skiniotis G, Garcia KC 10.1016/J.IMMUNI.2021.06.001 2021-07-07
Gi/o αi1 Human - 63 β1 Human γ2 Human cryo-EM 7JVR 7JVR_refined 2.8 DRD2 D2 Dopamine A (Rhodopsin) Human - scFv16 - Bromocriptine pubchem
small molecule Agonist dopamine small molecule Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE 10.1016/J.CELL.2021.01.027 2021-02-24
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7JVP 7JVP_refined 2.9 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - 39YLC3L0ZU pubchem
small molecule Agonist dopamine, noradrenaline, 5-hydroxytryptamine small molecule Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE 10.1016/J.CELL.2021.01.027 2021-02-24
Gs αs Human Engineered G alpha 60 β1 Human γ2 Human cryo-EM 7JVQ 7JVQ_refined 3.0 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - Apomorphine pubchem chembl_ligand
small molecule Agonist dopamine, noradrenaline, 5-hydroxytryptamine small molecule Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE 10.1016/J.CELL.2021.01.027 2021-02-24
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7JV5 7JV5_refined 3.0 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - 743408-71-1 pubchem chembl_ligand
small molecule Agonist dopamine, noradrenaline, 5-hydroxytryptamine small molecule Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE 10.1016/J.CELL.2021.01.027 2021-02-24
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 6PB1 6PB1_refined 2.8 CRFR2 CRF2 Corticotropin-releasing factor B1 (Secretin) Human - Nanobody-35 - Urocortin pubchem chembl_ligand
peptide Agonist urocortin 2, corticotrophin-releasing hormone, urocortin 1, urocortin 3 peptide Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE 10.1016/J.MOLCEL.2020.01.013 2020-02-12
Gs αs Human Gs-Gi1 chimera 58 β1 Human γ2 Human cryo-EM 6PB0 6PB0_refined 3.0 CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human - Nanobody-35 - Urocortin pubchem chembl_ligand
peptide Agonist urocortin 2, corticotrophin-releasing hormone, urocortin 1 peptide Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE 10.1016/J.MOLCEL.2020.01.013 2020-02-12
Gi/o αo Human - 61 β1 Human γ2 Human cryo-EM 7D77 7D77_refined 2.9 AGRG3 ADGRG3 ADGRG B2 (Adhesion) Human - scFv16 - Hydrocortisone pubchem
small molecule Agonist - - Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP 10.1038/S41586-020-03083-W 2021-02-03
Gi/o αo Human - 59 β1 Human γ2 Human cryo-EM 7D76 - 3.1 AGRG3 ADGRG3 ADGRG B2 (Adhesion) Human - - - Beclomethasone pubchem
small molecule Agonist - - Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP 10.1038/S41586-020-03083-W 2021-02-03
Gq/11 α11 Human - 63 β1 Human γ2 Human cryo-EM 6OIJ 6OIJ_refined 3.3 ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human - Antibody fragment - Iperoxo pubchem
small molecule Agonist acetylcholine small molecule Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK 10.1126/SCIENCE.AAW5188 2019-05-08
Gi/o αo Human - 61 β1 Human γ2 Human cryo-EM 6OIK 6OIK_refined 3.6 ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human - - - Iperoxo pubchem
2CU pubchem
small molecule
small molecule 		Agonist
PAM 		acetylcholine small molecule Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK 10.1126/SCIENCE.AAW5188 2019-05-08
Gs αs Human - 58 β1 Rat γ2 Bovine cryo-EM 7CZ5 7CZ5_refined 2.6 GHRHR GHRH Glucagon B1 (Secretin) Human - Nanobody-35 - Somatoliberin pubchem
peptide Agonist GHRH peptide Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW 10.1038/S41467-020-18945-0 2020-11-18
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 7E2Z 7E2Z_refined 3.1 5HT1A 5-HT1A 5-Hydroxytryptamine A (Rhodopsin) Human - - - Aripiprazole pubchem
small molecule Agonist (partial) 5-hydroxytryptamine small molecule Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE 10.1038/S41586-021-03376-8 2021-04-14
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 7E2Y 7E2Y_refined 3.0 5HT1A 5-HT1A 5-Hydroxytryptamine A (Rhodopsin) Human - - - Serotonin pubchem
small molecule Agonist 5-hydroxytryptamine small molecule Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE 10.1038/S41586-021-03376-8 2021-04-14
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 7E32 7E32_refined 2.9 5HT1D 5-HT1D 5-Hydroxytryptamine A (Rhodopsin) Human - scFv16 - Serotonin pubchem
small molecule Agonist 5-hydroxytryptamine, 5-HT-moduline small molecule Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE 10.1038/S41586-021-03376-8 2021-04-21
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 7E33 7E33_refined 2.9 5HT1E 5-HT1E 5-Hydroxytryptamine A (Rhodopsin) Human - scFv16 - 3-(1-Methylpiperidin-4-yl)-1H-indol-5-ol pubchem
small molecule Agonist 5-hydroxytryptamine, tryptamine small molecule Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE 10.1038/S41586-021-03376-8 2021-04-14
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 7E2X 7E2X_refined 3.0 5HT1A 5-HT1A 5-Hydroxytryptamine A (Rhodopsin) Human - - - Apo (no ligand)
none Apo (no ligand) 5-hydroxytryptamine small molecule Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE 10.1038/S41586-021-03376-8 2021-04-14
Gs αs Human - 59 β1 Rat γ2 Bovine cryo-EM 7DH5 7DH5_refined 3.2 ADRB3 β3 Adrenoceptors A (Rhodopsin) Dog - Nanobody-35 - Mirabegron pubchem
small molecule Agonist (-)-adrenaline, (-)-noradrenaline, (±)-adrenaline small molecule Nagiri C, Kobayashi K, Tomita A, Kato M, Kobayashi K, Yamashita K, Nishizawa T, Inoue A, Shihoya W, Nureki O 10.1016/J.MOLCEL.2021.06.024 2021-08-04
Gs αs Human Mini-Gs 61 β1 Human γ2 Human cryo-EM 6LI3 6LI3_refined 3.3 GPR52 GPR52 A orphans A (Rhodopsin) Human - Nanobody-35 - Apo (no ligand)
none Apo (no ligand) - - Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F 10.1038/S41586-020-2019-0 2020-02-26
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 6PT0 6PT0_refined 3.2 CNR2 CB2 Cannabinoid A (Rhodopsin) Human - scFv16 - Win 55212-2 pubchem chembl_ligand
small molecule Agonist 2-arachidonoylglycerol, anandamide small molecule Xing C, Zhuang Y, Xu TH, Feng Z, Zhou XE, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire TF, Zhao G, Melcher K, Zhang C, Xu HE, Xie XQ 10.1016/J.CELL.2020.01.007 2020-02-12
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 7EXD 7EXD_refined 3.4 5HT1F 5-HT1F 5-Hydroxytryptamine A (Rhodopsin) Human BRIL scFv16 - Lasmiditan pubchem
small molecule Agonist 5-hydroxytryptamine small molecule Huang S, Xu P, Tan Y, You C, Zhang Y, Jiang Y, Xu HE 10.1038/S41422-021-00527-4 2021-08-04
Gi/o αi1 Human - 64 β1 Human γ2 Human cryo-EM 7CMU 7CMU_refined 3.0 DRD3 D3 Dopamine A (Rhodopsin) Human BRIL scFv16 - Pramipexole pubchem
small molecule Agonist dopamine small molecule Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE 10.1016/J.MOLCEL.2021.01.003 2021-03-10
Gi/o αi1 Human - 64 β1 Human γ2 Human cryo-EM 7CMV 7CMV_refined 2.7 DRD3 D3 Dopamine A (Rhodopsin) Human BRIL scFv16 Gi (4Ar,10bR)-rel-4-Propyl-2,3,4,4a,5,10b-hexahydrochromeno[4,3-b][1,4]oxazin-9-ol pubchem chembl_ligand
small molecule Agonist dopamine small molecule Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE 10.1016/J.MOLCEL.2021.01.003 2021-03-10
Gs αs Human - 59 β1 Human γ2 Human cryo-EM 7CFN 7CFN_refined 3.0 GPBAR GPBA Bile acid A (Rhodopsin) Human - Nanobody-35 - INT-777 pubchem
INT-777 pubchem
small molecule
small molecule 		Agonist
PAM 		chenodeoxycholic acid, cholic acid, deoxycholic acid, lithocholic acid small molecule Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y 10.1038/S41586-020-2569-1 2020-09-09
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 7CFM 7CFM_refined 3.0 GPBAR GPBA Bile acid A (Rhodopsin) Human - Nanobody-35 - P395 pubchem chembl_ligand
small molecule Agonist chenodeoxycholic acid, cholic acid, deoxycholic acid, lithocholic acid small molecule Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y 10.1038/S41586-020-2569-1 2020-09-09
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6WPW 6WPW_refined 3.1 GLR glucagon Glucagon B1 (Secretin) Human - Nanobody-35 - Glucagon derivative ZP3780
peptide Agonist glucagon peptide Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK 10.1126/SCIENCE.ABA3373 2020-08-12
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 6N4B 6N4B_refined 3.0 CNR1 CB1 Cannabinoid A (Rhodopsin) Human - scFv16 - Fub-mdmb pubchem
small molecule Agonist 2-arachidonoylglycerol, anandamide small molecule Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G 10.1016/J.CELL.2018.11.040 2019-01-30
Gs αs Human - 59 β1 Human γ2 Human cryo-EM 7AUE 7AUE_refined 3.0 MC4R MC4 Melanocortin A (Rhodopsin) Human - scFv16 - Aminoserine
peptide Agonist agouti, α-MSH, ACTH, γ-MSH, β-MSH, agouti-related protein protein Israeli H, Degtjarik O, Fierro F, Chunilal V, Gill AK, Roth NJ, Botta J, Prabahar V, Peleg Y, Chan LF, Ben-Zvi D, McCormick PJ, Niv MY, Shalev-Benami M 10.1126/SCIENCE.ABF7958 2021-04-28
Gs αs Human Engineered G protein 50 - - - - X-ray 5G53 5G53_refined 3.4 AA2AR A2A Adenosine A (Rhodopsin) Human - - - NECA pubchem
small molecule Agonist adenosine small molecule Carpenter B, Nehme R, Warne T, Leslie AG, Tate CG 10.1038/NATURE18966 2016-08-03
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 7KH0 7KH0_refined 2.8 V2R V2 Vasopressin and oxytocin A (Rhodopsin) Human - scFv16
Nanobody-35 		- Argipressin pubchem chembl_ligand
peptide Agonist vasopressin, oxytocin peptide Wang L, Xu J, Cao S, Sun D, Liu H, Lu Q, Liu Z, Du Y, Zhang C 10.1038/S41422-021-00483-Z 2021-05-26
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6WI9 6WI9_refined 4.3 SCTR secretin Glucagon B1 (Secretin) Human - Nanobody-35 - secretin
peptide Agonist secretin, VIP peptide Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ 10.1038/S41467-020-17791-4 2020-08-12
Gs αs Human - 61 β1 Human γ2 Human cryo-EM 6WZG 6WZG_refined 2.3 SCTR secretin Glucagon B1 (Secretin) Human - Nanobody-35 - secretin
peptide Agonist secretin, VIP peptide Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ 10.1038/S41467-020-17791-4 2020-08-12
Gs αs Human - 58 β1 Rat γ2 Bovine cryo-EM 7F16 7F16_refined 2.8 PTH2R PTH2 Parathyroid hormone B1 (Secretin) Human - Nanobody-35 - TIP39
peptide Agonist TIP39, PTH, PTHrP-(1-36), PTHrP-(1-34) (human) peptide Wang X, Cheng X, Zhao L, Wang Y, Ye C, Zou X, Dai A, Cong Z, Chen J, Zhou Q, Xia T, Jiang H, Xu HE, Yang D, Wang MW 10.1073/PNAS.2101279118 2021-08-18
Gq/11 αq Human Gq-Gi2-Gs chimera 59 β1 Human γ2 Human cryo-EM 6WHA 6WHA_refined 3.4 5HT2A 5-HT2A 5-Hydroxytryptamine A (Rhodopsin) Human BRIL scFv16 Gq 25-CN-NBOH pubchem
small molecule Agonist 5-hydroxytryptamine, tryptamine small molecule Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL 10.1016/J.CELL.2020.08.024 2020-09-23
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6P9X 6P9X_refined 2.9 CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human - Nanobody-35 - Corticoliberin pubchem
peptide Agonist urocortin 2, corticotrophin-releasing hormone, urocortin 1 peptide Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D 10.1016/J.MOLCEL.2020.01.012 2020-02-05
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6P9Y 6P9Y_refined 3.0 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - PACAP pubchem
peptide Agonist VIP, PACAP-27, PACAP-38, PHM, PHV, PHI peptide Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D 10.1016/J.MOLCEL.2020.01.012 2020-02-05
Gs αs Human - 61 β1 Human γ2 Human cryo-EM 6VN7 6VN7_refined 3.2 VIPR1 VPAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - PACAP pubchem
peptide Agonist secretin, GHRH, VIP, PACAP-27, PACAP-38, PHM, PHV, PHI peptide Duan J, Shen DD, Zhou XE, Bi P, Liu QF, Tan YX, Zhuang YW, Zhang HB, Xu PY, Huang SJ, Ma SS, He XH, Melcher K, Zhang Y, Xu HE, Jiang Y 10.1038/S41467-020-17933-8 2020-09-02
Gs αs Human - 89 β1 Human γ2 Human cryo-EM 6X1A 6X1A_refined 2.5 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - PF-06882961 pubchem
small molecule Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide None 10.1101/2020.08.16.252585 2020-09-09
Gs αs Human - 89 β1 Human γ2 Human cryo-EM 6X19 6X19_refined 2.1 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - CHU-128 pubchem
small molecule Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide None 10.1101/2020.08.16.252585 2020-09-09
Gs αs Human - 90 β1 Human γ2 Human cryo-EM 6X18 6X18_refined 2.1 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - GLP-1
peptide Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide None 10.1101/2020.08.16.252585 2020-09-09
Gs αs Bovine - 57 β1 Bovine γ2 Bovine cryo-EM 7D68 7D68_refined 3.0 GLP2R GLP-2 Glucagon B1 (Secretin) Human - Nanobody-35 - glucagon pubchem
peptide Agonist glucagon-like peptide 2-(2-33), glucagon-like peptide 2, glucagon-like peptide 2-(3-33) peptide Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, Zhao S, Jiang Y, Rosenkilde MM, Xu HE, Zhang Y, Wang MW 10.1038/S41422-020-00442-0 2020-12-16
Gs αs Human Engineered G alpha 58 β1 Human γ2 Human cryo-EM 7L1U 7L1U_refined 3.2 OX2R OX2 Orexin A (Rhodopsin) Human - scFv16 - orexin-A
peptide Agonist orexin-A, orexin-B peptide Hong C, Byrne NJ, Zamlynny B, Tummala S, Xiao L, Shipman JM, Partridge AT, Minnick C, Breslin MJ, Rudd MT, Stachel SJ, Rada VL, Kern JC, Armacost KA, Hollingsworth SA, O'Brien JA, Hall DL, McDonald TP, Strickland C, Brooun A, Soisson SM, Hollenstein K 10.1038/S41467-021-21087-6 2021-02-10
Gs αs Human Engineered G alpha 58 β1 Human γ2 Human cryo-EM 7L1V 7L1V_refined 3.0 OX2R OX2 Orexin A (Rhodopsin) Human - scFv16 Sb51 4'-Methoxy-N,N-dimethyl-3'-{[3-(2-{[2-(2H-1,2,3-triazol-2-yl)benzene-1-carbonyl]amino}ethyl)phenyl]sulfamoyl}[1,1'-biphenyl]-3-carboxamide pubchem
small molecule Agonist orexin-A, orexin-B peptide Hong C, Byrne NJ, Zamlynny B, Tummala S, Xiao L, Shipman JM, Partridge AT, Minnick C, Breslin MJ, Rudd MT, Stachel SJ, Rada VL, Kern JC, Armacost KA, Hollingsworth SA, O'Brien JA, Hall DL, McDonald TP, Strickland C, Brooun A, Soisson SM, Hollenstein K 10.1038/S41467-021-21087-6 2021-02-10
Gi/o αi2 Human - 59 β1 Human γ2 Human cryo-EM 6D9H 6D9H_refined 3.6 AA1R A1 Adenosine A (Rhodopsin) Human - - - adenosine pubchem
small molecule Agonist adenosine small molecule Draper-Joyce CJ, Khoshouei M, Thal DM, Liang YL, Nguyen ATN, Furness SGB, Venugopal H, Baltos JA, Plitzko JM, Danev R, Baumeister W, May LT, Wootten D, Sexton PM, Glukhova A, Christopoulos A 10.1038/S41586-018-0236-6 2018-06-20
Gs αs Human - 43 β1 Human γ2 Human cryo-EM 6NIY 6NIY_refined 3.3 CALCR CT Calcitonin B1 (Secretin) Human - - - calcitonin
peptide Agonist calcitonin, adrenomedullin, amylin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin peptide Dal Maso E, Glukhova A, Zhu Y, Garcia-Nafria J, Tate CG, Atanasio S, Reynolds CA, Ramirez-Aportela E, Carazo JM, Hick CA, Furness SGB, Hay DL, Liang YL, Miller LJ, Christopoulos A, Wang MW, Wootten D, Sexton PM 10.1021/ACSPTSCI.8B00056 2019-01-23
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6UVA 6UVA_refined 2.3 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP3 		- Adrenomedullin-2
peptide Agonist adrenomedullin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin, α-CGRP-(8-37) (rat) peptide Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM 10.1021/ACSPTSCI.9B00080 2020-04-01
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6UUN 6UUN_refined 3.0 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP2 		- adrenomedullin
peptide Agonist adrenomedullin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin, α-CGRP-(8-37) (rat) peptide Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM 10.1021/ACSPTSCI.9B00080 2020-03-25
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6UUS 6UUS_refined 2.4 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP3 		- adrenomedullin
peptide Agonist adrenomedullin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin, α-CGRP-(8-37) (rat) peptide Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM 10.1021/ACSPTSCI.9B00080 2020-04-01
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBK 6XBK_refined 3.2 SMO SMO Frizzled F (Frizzled) Human - scFv16 - Cholesterol pubchem
N/A Agonist constitutive constitutive Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X 10.1038/S41589-020-0646-2 2020-09-30
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBM 6XBM_refined 3.2 SMO SMO Frizzled F (Frizzled) Human - scFv16 - 24,25-Epoxy-cholesterol pubchem
24,25-Epoxy-cholesterol pubchem
small molecule
small molecule 		Agonist
PAM 		constitutive constitutive Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X 10.1038/S41589-020-0646-2 2020-09-30
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBJ 6XBJ_refined 3.9 SMO SMO Frizzled F (Frizzled) Human - scFv16 - Cholesterol pubchem
N/A Agonist constitutive constitutive Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X 10.1038/S41589-020-0646-2 2020-09-30
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6XBL 6XBL_refined 3.9 SMO SMO Frizzled F (Frizzled) Human - scFv16 - Cholesterol pubchem
SAG pubchem
N/A
small molecule 		Agonist
PAM 		constitutive constitutive Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X 10.1038/S41589-020-0646-2 2020-09-30
Gs αs Bovine - 89 β1 Rat γ2 Bovine X-ray 3SN6 3SN6_refined 3.2 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human T4-Lysozyme Antibody - BI-167107 pubchem
small molecule Agonist noradrenaline, (-)-adrenaline, (-)-noradrenaline, Zn2+ small molecule Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK 10.1038/NATURE10361 2011-07-20
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 7F1R 7F1R_refined 3.0 CCR5 CCR5 Chemokine A (Rhodopsin) Human - - - CCL5
protein Agonist CCL5, CCL3, CCL16, CCL14, CCL7, CCL13, CCL8, CCL4, CCL2, CCL11 protein Zhang H, Chen K, Tan Q, Shao Q, Han S, Zhang C, Yi C, Chu X, Zhu Y, Xu Y, Zhao Q, Wu B 10.1038/S41467-021-24438-5 2021-07-14
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 7F1Q 7F1Q_refined 2.9 CCR5 CCR5 Chemokine A (Rhodopsin) Human - - - CCL3
protein Agonist CCL5, CCL3, CCL16, CCL14, CCL7, CCL13, CCL8, CCL4, CCL2, CCL11 protein Zhang H, Chen K, Tan Q, Shao Q, Han S, Zhang C, Yi C, Chu X, Zhu Y, Xu Y, Zhao Q, Wu B 10.1038/S41467-021-24438-5 2021-07-14
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 7F1S 7F1S_refined 2.8 CCR5 CCR5 Chemokine A (Rhodopsin) Human - - - Apo (no ligand)
none Apo (no ligand) CCL5, CCL3, CCL16, CCL14, CCL7, CCL13, CCL8, CCL4, CCL2, CCL11 protein Zhang H, Chen K, Tan Q, Shao Q, Han S, Zhang C, Yi C, Chu X, Zhu Y, Xu Y, Zhao Q, Wu B 10.1038/S41467-021-24438-5 2021-07-14
Gs αs Human - 53 β1 Human γ2 Human cryo-EM 7KI0 - 2.5 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - Semaglutide pubchem chembl_ligand pubchem
peptide Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Zhang X, Belousoff MJ, Liang YL, Danev R, Sexton PM, Wootten D 10.1016/J.CELREP.2021.109374 2021-08-04
Gs αs Human - 89 β1 Human γ2 Human cryo-EM 7KI1 7KI1_refined 2.5 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - Taspoglutide pubchem
peptide Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Zhang X, Belousoff MJ, Liang YL, Danev R, Sexton PM, Wootten D 10.1016/J.CELREP.2021.109374 2021-08-04
Gs αs Human - 57 β1 Human γ2 Human cryo-EM 6GDG 6GDG_refined 4.1 AA2AR A2A Adenosine A (Rhodopsin) Human TrxA Nanobody - NECA pubchem
small molecule Agonist adenosine small molecule Garcia-Nafria J, Lee Y, Bai X, Carpenter B, Tate CG 10.7554/ELIFE.35946 2018-05-16
Gs αs Human - 56 β1 Rat γ2 Bovine cryo-EM 7BW0 7BW0_refined 3.9 GPBAR GPBA Bile acid A (Rhodopsin) Human BRIL Nanobody-35 - - - - chenodeoxycholic acid, cholic acid, deoxycholic acid, lithocholic acid small molecule Chen G, Wang X, Ge Y, Ma L, Chen Q, Liu H, Du Y, Ye RD, Hu H, Ren R 10.1038/S41392-020-00262-Z 2020-09-02
Gs αs Human - 61 β1 Rat γ2 Bovine cryo-EM 7DUQ 7DUQ_refined 2.5 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - N-Tert-butyl-6,7-dichloroquinoxalin-2-amine pubchem
Glucagon-like peptide 1 pubchem
small molecule
peptide 		Ago-PAM
Agonist 		glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW 10.1038/S41467-021-24058-Z 2021-07-14
Gs αs Human - 60 β1 Rat γ2 Bovine cryo-EM 7EVM 7EVM_refined 2.5 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - N-Tert-butyl-6,7-dichloroquinoxalin-2-amine pubchem
small molecule Ago-PAM glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW 10.1038/S41467-021-24058-Z 2021-08-11
Gs αs Human - 48 β1 Bovine γ2 Mouse cryo-EM 7E14 7E14_refined 2.9 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - N-Tert-butyl-6,7-dichloroquinoxalin-2-amine pubchem
3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one pubchem
small molecule
small molecule 		Ago-PAM
Agonist 		glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW 10.1038/S41467-021-24058-Z 2021-07-07
Gs αs Human - 60 β1 Rat γ2 Bovine cryo-EM 7DUR 7DUR_refined 3.3 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - N-Tert-butyl-6,7-dichloroquinoxalin-2-amine pubchem
small molecule Ago-PAM glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW 10.1038/S41467-021-24058-Z 2021-08-11
Gs αs Human - 49 β1 Human γ2 Human cryo-EM 6B3J 6B3J_refined 3.3 GLP1R GLP-1 Glucagon B1 (Secretin) Human - - - Exendin-P5
peptide Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D 10.1038/NATURE25773 2018-02-21
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6E3Y 6E3Y_refined 3.3 CALRL calcitonin-like Calcitonin B1 (Secretin) Human - Nanobody-35
RAMP1 		- Calcitonin gene-related peptide 1 pubchem
peptide Agonist adrenomedullin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin, α-CGRP-(8-37) (rat) peptide Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM 10.1038/S41586-018-0535-Y 2018-09-19
Gs αs Human - 58 β1 Rat γ2 Bovine cryo-EM 7D3S 7D3S_refined 2.9 SCTR secretin Glucagon B1 (Secretin) Human - Nanobody-35 - secretin
peptide Agonist secretin, VIP peptide Fukuhara S, Kobayashi K, Kusakizako T, Iida W, Kato M, Shihoya W, Nureki O 10.1016/J.BBRC.2020.08.042 2020-11-04
Gs αs Human - 57 β1 Rat γ2 Bovine cryo-EM 6LPB 6LPB_refined 3.9 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - PACAP pubchem
peptide Agonist VIP, PACAP-27, PACAP-38, PHM, PHV, PHI peptide Kobayashi K, Shihoya W, Nishizawa T, Kadji FMN, Aoki J, Inoue A, Nureki O 10.1038/S41594-020-0386-8 2020-03-11
Gi/o αi1 Human - 64 β1 Human γ2 Human cryo-EM 6KPG 6KPG_refined 3.0 CNR1 CB1 Cannabinoid A (Rhodopsin) Human - scFv16 - (6Ar,9R,10aR)-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyloctan-2-yl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol pubchem
small molecule Agonist 2-arachidonoylglycerol, anandamide small molecule Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ 10.1016/J.CELL.2020.01.008 2020-02-12
Gi/o αi1 Human - 62 β1 Human γ2 Human cryo-EM 6KPF 6KPF_refined 2.9 CNR2 CB2 Cannabinoid A (Rhodopsin) Human - scFv16 - (6Ar,9R,10aR)-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyloctan-2-yl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol pubchem
small molecule Agonist 2-arachidonoylglycerol, anandamide small molecule Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ 10.1016/J.CELL.2020.01.008 2020-02-12
Gi/o αi3 Human - 63 β1 Human γ2 Human cryo-EM 7E9H 7E9H_refined 4.0 GRM4 mGlu4 Metabotropic glutamate C (Glutamate) Human - scFv16 Gi3 Phosphoserine pubchem chembl_ligand pubchem
small molecule Agonist L-glutamic acid, L-serine-O-phosphate amino acid Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X, Dai A, Zhou Y, Chen Y, Zhou Y, Liu H, Liu J, Yang D, Wang MW, Zhao Q, Wu B 10.1038/S41586-021-03495-2 2021-06-23
Gi/o αi1 Human - 63 β1 Human γ2 Human cryo-EM 7E9G 7E9G_refined 3.5 GRM2 mGlu2 Metabotropic glutamate C (Glutamate) Human - scFv16 DN13 Eglumetad pubchem
1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one pubchem chembl_ligand
small molecule
small molecule 		Agonist
PAM 		L-glutamic acid amino acid Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X, Dai A, Zhou Y, Chen Y, Zhou Y, Liu H, Liu J, Yang D, Wang MW, Zhao Q, Wu B 10.1038/S41586-021-03495-2 2021-06-23
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7CRH 7CRH_refined 3.3 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-, (1S)- pubchem chembl_ligand
small molecule Agonist dopamine, noradrenaline, 5-hydroxytryptamine small molecule Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z 10.1016/J.CELL.2021.01.028 2021-03-03
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7CKZ 7CKZ_refined 3.1 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - dopamine pubchem
Mevidalen pubchem
small molecule
small molecule 		Agonist
PAM 		dopamine, noradrenaline, 5-hydroxytryptamine small molecule Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z 10.1016/J.CELL.2021.01.028 2021-03-03
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7CKY 7CKY_refined 3.2 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - 6-[4-[3-(Difluoromethoxy)pyridin-2-yl]oxy-2-methylphenyl]-1,5-dimethylpyrimidine-2,4-dione pubchem chembl_ligand
small molecule Agonist dopamine, noradrenaline, 5-hydroxytryptamine small molecule Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z 10.1016/J.CELL.2021.01.028 2021-03-03
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7CKX 7CKX_refined 3.5 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - (1R,3S)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol
small molecule Agonist dopamine, noradrenaline, 5-hydroxytryptamine small molecule Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z 10.1016/J.CELL.2021.01.028 2021-03-03
Gs αs Human - 60 β1 Human γ2 Human cryo-EM 7CKW 7CKW_refined 3.2 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - Fenoldopam pubchem
small molecule Agonist dopamine, noradrenaline, 5-hydroxytryptamine small molecule Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z 10.1016/J.CELL.2021.01.028 2021-03-03
Gs αs Human - 55 β1 Human γ2 Human cryo-EM 7BB7 7BB7_refined 4.4 V2R V2 Vasopressin and oxytocin A (Rhodopsin) Human - Nanobody-35 - Argipressin pubchem chembl_ligand
peptide Agonist vasopressin, oxytocin peptide Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B 10.1126/SCIADV.ABG5628 2021-06-02
Gs αs Human - 54 β1 Human γ2 Human cryo-EM 7BB6 7BB6_refined 4.2 V2R V2 Vasopressin and oxytocin A (Rhodopsin) Human - Nanobody-35 - Argipressin pubchem chembl_ligand
peptide Agonist vasopressin, oxytocin peptide Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B 10.1126/SCIADV.ABG5628 2021-06-02
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6OMM 6OMM_refined 3.2 FPR2 FPR2/ALX Formylpeptide A (Rhodopsin) Human - - - WKYMVX
peptide Agonist annexin I, humanin, LL-37, serum amyloid A, PrP106-126, CRAMP, LXA4, aspirin triggered lipoxin A4, resolvin D1, aspirin-triggered resolvin D1 protein Zhuang Y, Liu H, Edward Zhou X, Kumar Verma R, de Waal PW, Jang W, Xu TH, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert NA, Eric Xu H, Zhang C 10.1038/S41467-020-14728-9 2020-02-26
Gs αs Human - 57 β1 Human γ2 Human cryo-EM 6VCB 6VCB_refined 3.3 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - GLP-1
LSN3160440 pubchem
peptide
small molecule 		Agonist
PAM 		glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Bueno AB, Sun B, Willard FS, Feng D, Ho JD, Wainscott DB, Showalter AD, Vieth M, Chen Q, Stutsman C, Chau B, Ficorilli J, Agejas FJ, Cumming GR, Jimenez A, Rojo I, Kobilka TS, Kobilka BK, Sloop KW 10.1038/S41589-020-0589-7 2020-07-22
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 7EVW - 3.2 FZD7 FZD7 Frizzled F (Frizzled) Human - Nanobody-35 - Apo (no ligand)
none Apo (no ligand) - - Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu F 10.1038/S41422-021-00525-6 2021-08-04
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6M1I 6M1I_refined 3.5 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - PACAP pubchem
peptide Agonist VIP, PACAP-27, PACAP-38, PHM, PHV, PHI peptide Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y 10.1038/S41422-020-0280-2 2020-03-11
Gs αs Human - 54 β1 Human γ2 Human cryo-EM 6M1H 6M1H_refined 3.6 PACR PAC1 VIP and PACAP B1 (Secretin) Human - Nanobody-35 - Maxadilan pubchem
peptide Agonist VIP, PACAP-27, PACAP-38, PHM, PHV, PHI peptide Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y 10.1038/S41422-020-0280-2 2020-03-11
Gi/o αt1 Bovine - 59 β1 Bovine γT1 Bovine cryo-EM 6OYA 6OYA_refined 3.3 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - Camelid antibody VHH fragment - Retinal (all-trans) pubchem
small molecule Agonist Retinal small molecule Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G 10.1016/J.MOLCEL.2019.06.007 2019-07-24
Gi/o αt1 Bovine - 64 β1 Bovine γT1 Bovine cryo-EM 6OY9 6OY9_refined 3.9 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - - - Retinal (all-trans) pubchem
small molecule Agonist Retinal small molecule Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G 10.1016/J.MOLCEL.2019.06.007 2019-07-24
Gs αs Bovine - 51 β1 Bovine γ2 Bovine cryo-EM 7JJO 7JJO_refined 2.6 ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey - Nanobody-35 - Isoprenaline pubchem
small molecule Agonist noradrenaline, (-)-adrenaline, (-)-noradrenaline small molecule Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee MY, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang XY 10.1016/J.MOLCEL.2020.08.001 2020-09-02
Gi/o αi1 Human - 64 β1 Human γ2 Human cryo-EM 6VMS 6VMS_refined 3.8 DRD2 D2 Dopamine A (Rhodopsin) Human T4-Lysozyme scFv16 - Bromocriptine pubchem
small molecule Agonist dopamine small molecule Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM 10.1038/S41586-020-2379-5 2020-06-17
Gs αs Human Engineered G alpha 58 β1 Rat γ2 Bovine cryo-EM 7LJC - 3.0 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - 743408-71-1 pubchem chembl_ligand
Mevidalen pubchem
small molecule
small molecule 		Agonist
PAM 		dopamine, noradrenaline, 5-hydroxytryptamine small molecule None 10.1101/2021.02.07.430101 2021-03-03
Gs αs Human Engineered G alpha 58 β1 Rat γ2 Bovine cryo-EM 7LJD - 3.2 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - dopamine pubchem
Mevidalen pubchem
small molecule
small molecule 		Agonist
PAM 		dopamine, noradrenaline, 5-hydroxytryptamine small molecule None 10.1101/2021.02.07.430101 2021-03-03
Gs αs Human - 47 β1 Human γ2 Human cryo-EM 5UZ7 5UZ7_refined 4.1 CALCR CT Calcitonin B1 (Secretin) Human - - - - - - calcitonin, adrenomedullin, amylin, α-CGRP, β-CGRP, adrenomedullin 2/intermedin peptide Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM 10.1038/NATURE22327 2017-05-03
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6WHC 6WHC_refined 3.4 GLR glucagon Glucagon B1 (Secretin) Human - Nanobody-35 - Dual-agonist peptide P15
peptide Agonist glucagon peptide Chang R, Zhang X, Qiao A, Dai A, Belousoff MJ, Tan Q, Shao L, Zhong L, Lin G, Liang YL, Ma L, Han S, Yang D, Danev R, Wang MW, Wootten D, Wu B, Sexton PM 10.1074/JBC.RA120.013793 2020-05-27
Gi/o αi1 Human - 99 β1 Human γ2 Human cryo-EM 7EB2 7EB2_refined 3.5 GABR2 GABAB2 GABAB C (Glutamate) Human - scFv16 - Baclofen pubchem
BHFF pubchem
small molecule
small molecule 		Agonist
PAM 		GABA small molecule Shen C, Mao C, Xu C, Jin N, Zhang H, Shen DD, Shen Q, Wang X, Hou T, Chen Z, Rondard P, Pin JP, Zhang Y, Liu J 10.1038/S41586-021-03507-1 2021-05-05
Gi/o αi1 Human - 62 β1 Bovine γ2 Bovine cryo-EM 7O7F 7O7F_refined 3.2 CCR5 CCR5 Chemokine A (Rhodopsin) Human - Fab heavy chain
Fab light chain 		- CCL5
protein Agonist CCL5, CCL3, CCL16, CCL14, CCL7, CCL13, CCL8, CCL4, CCL2, CCL11 protein Isaikina P, Tsai CJ, Dietz N, Pamula F, Grahl A, Goldie KN, Guixa-Gonzalez R, Branco C, Paolini-Bertrand M, Calo N, Cerini F, Schertler GFX, Hartley O, Stahlberg H, Maier T, Deupi X, Grzesiek S 10.1126/SCIADV.ABG8685 2021-06-30
Gs αs Human - 56 β1 Human γ2 Human cryo-EM 6XOX 6XOX_refined 3.1 GLP1R GLP-1 Glucagon B1 (Secretin) Human - scFv16
Nanobody-35 		- 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one pubchem
small molecule Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Kawai T, Sun B, Yoshino H, Feng D, Suzuki Y, Fukazawa M, Nagao S, Wainscott DB, Showalter AD, Droz BA, Kobilka TS, Coghlan MP, Willard FS, Kawabe Y, Kobilka BK, Sloop KW 10.1073/PNAS.2014879117 2020-11-18
Gs αs Human - 50 β1 Bovine γ2 Bovine cryo-EM 7BZ2 7BZ2_refined 3.8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human - Nanobody-35 - Formoterol pubchem chembl_ligand
small molecule Agonist noradrenaline, (-)-adrenaline, (-)-noradrenaline, Zn2+ small molecule Zhang Y, Yang F, Ling S, Lv P, Zhou Y, Fang W, Sun W, Zhang L, Shi P, Tian C 10.1038/S41421-020-0176-9 2020-08-05
Gs αs Human - 56 β1 Rat γ2 Bovine cryo-EM 7DW9 - 2.6 V2R V2 Vasopressin and oxytocin A (Rhodopsin) Human - Nanobody-35
scFv16 		- CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
peptide Agonist vasopressin, oxytocin peptide Zhou F, Ye C, Ma X, Yin W, Croll TI, Zhou Q, He X, Zhang X, Yang D, Wang P, Xu HE, Wang MW, Jiang Y 10.1038/S41422-021-00480-2 2021-07-21
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 6OT0 - 3.9 SMO SMO Frizzled F (Frizzled) Human - Fab light chain
Fab heavy chain 		- 24,25-Epoxy-cholesterol pubchem
small molecule Agonist constitutive constitutive Qi X, Liu H, Thompson B, McDonald J, Zhang C, Li X 10.1038/S41586-019-1286-0 2019-06-12
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6DDE 6DDE_refined 3.5 OPRM μ Opioid A (Rhodopsin) Mouse - Antibody - DAMGO pubchem chembl_ligand
peptide Agonist [Leu]enkephalin, [Met]enkephalin, dynorphin A-(1-13), dynorphin A, dynorphin A-(1-8), dynorphin B, endomorphin-1, β-endorphin, endomorphin-2 peptide Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK 10.1038/S41586-018-0219-7 2018-06-13
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 6DDF 6DDF_refined 3.5 OPRM μ Opioid A (Rhodopsin) Mouse - - - DAMGO pubchem chembl_ligand
peptide Agonist [Leu]enkephalin, [Met]enkephalin, dynorphin A-(1-13), dynorphin A, dynorphin A-(1-8), dynorphin B, endomorphin-1, β-endorphin, endomorphin-2 peptide Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK 10.1038/S41586-018-0219-7 2018-06-13
Gs αs Human - 59 β1 Rat γ2 Bovine cryo-EM 5VAI 5VAI_refined 4.1 G1SGD4 GLP-1 Glucagon B1 (Secretin) Rabbit - - - GLP-1
peptide Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G 10.1038/NATURE22394 2017-05-24
Gi/o αi1 Human - 100 β1 Rat γ2 Bovine cryo-EM 6CMO 6CMO_refined 4.5 OPSD Rhodopsin Opsins A (Rhodopsin) Human BRIL Fab - Apo (no ligand)
none Apo (no ligand) Retinal small molecule Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE 10.1038/S41586-018-0215-Y 2018-06-20
Gs αs Human - 59 β1 Human γ2 Human cryo-EM 6LMK 6LMK_refined 3.7 GLR glucagon Glucagon B1 (Secretin) Human - Nanobody-35 - glucagon pubchem
peptide Agonist glucagon peptide Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B 10.1126/SCIENCE.AAZ5346 2020-04-01
Gi/o αi1 Human - 63 β1 Human γ2 Human cryo-EM 6LML 6LML_refined 3.9 GLR glucagon Glucagon B1 (Secretin) Human - scFv16 - glucagon pubchem
peptide Agonist glucagon peptide Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B 10.1126/SCIENCE.AAZ5346 2020-04-01
Gi/o αo Human Mini-Go 51 - - - - X-ray 6FUF 6FUF_refined 3.1 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - - - Retinal (all-trans) pubchem
small molecule Agonist Retinal small molecule Tsai CJ, Pamula F, Nehme R, Muhle J, Weinert T, Flock T, Nogly P, Edwards PC, Carpenter B, Gruhl T, Ma P, Deupi X, Standfuss J, Tate CG, Schertler GFX 10.1126/SCIADV.AAT7052 2018-10-03
Gs αs Human - 55 β1 Bovine γ2 Bovine cryo-EM 7DHI 7DHI_refined 3.3 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human - Nanobody-35 - Salbutamol pubchem
small molecule Agonist noradrenaline, (-)-adrenaline, (-)-noradrenaline, Zn2+ small molecule Babu SH, Rapaport BHJ 10.1093/NSR/NWAA284 2020-12-16
Gs αs Human - 49 β1 Bovine γ2 Bovine cryo-EM 7DHR 7DHR_refined 3.8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human - Nanobody-35 - Isoprenaline pubchem
small molecule Agonist noradrenaline, (-)-adrenaline, (-)-noradrenaline, Zn2+ small molecule Babu SH, Rapaport BHJ 10.1093/NSR/NWAA284 2020-12-16
Gi/o αi1 Human - 60 β1 Bovine γT1 Bovine cryo-EM 6QNO 6QNO_refined 4.4 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - Fab antibody fragment light chain
Fab antibody fragment heavy chain 		- Retinal (all-trans) pubchem
small molecule Agonist Retinal small molecule Tsai CJ, Marino J, Adaixo R, Pamula F, Muehle J, Maeda S, Flock T, Taylor NM, Mohammed I, Matile H, Dawson RJ, Deupi X, Stahlberg H, Schertler G 10.7554/ELIFE.46041 2019-07-10
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 7C2E 7C2E_refined 4.2 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid pubchem
small molecule Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Ma H, Huang W, Wang X, Zhao L, Jiang Y, Liu F, Guo W, Sun X, Zhong W, Yuan D, Xu HE 10.1038/S41422-020-0384-8 2020-08-26
Gs αs Human - 48 β1 Human γ2 Human cryo-EM 6ORV - 3.0 GLP1R GLP-1 Glucagon B1 (Secretin) Human - Nanobody-35 - TT-OAD2 pubchem
small molecule Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide Zhao P, Liang YL, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang MW, Miller LJ, Reynolds CA, Danev R, Sexton PM, Wootten D 10.1038/s41586-019-1902-z 2020-01-08
Gs αs Human - 59 β1 Human γ2 Human cryo-EM 6NI3 6NI3_refined 3.8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human - Nanobody-35 - BI-167107 pubchem
small molecule Agonist noradrenaline, (-)-adrenaline, (-)-noradrenaline, Zn2+ small molecule Nguyen AH, Thomsen ARB, Cahill TJ 3rd, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J 4th, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ 10.1038/S41594-019-0330-Y 2019-11-20
Gi/o αi1 Human Non-canonical conformation 95 β1 Human γT1 Human cryo-EM 7L0S 7L0S_refined 4.5 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat - - - neurotensin pubchem
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide - - 2021-01-06
Gs αs Human - 62 β1 Human γ2 Human cryo-EM 7LCI 7LCI_refined 2.9 GLP1R GLP-1 Glucagon B1 (Secretin) Human - - - PF-06882961 pubchem
small molecule Agonist glucagon, glucagon-like peptide 1-(7-36) amide, glucagon-like peptide 1-(7-37) peptide - - 2021-01-20
Gi/o αi1 Human - 63 β1 Human γT1 Human cryo-EM 7L0P 7L0P_refined 4.1 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat - - - neurotensin pubchem
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide - - 2021-01-06
Gs αs Human - 86 β1 Human γ2 Human X-ray 7JOZ 7JOZ_refined 3.8 DRD1 D1 Dopamine A (Rhodopsin) Human - Nanobody-35 - 6-{4-[(furo[3,2-c]pyridin-4-yl)oxy]-2-methylphenyl}-1,5-dimethylpyrimidine-2,4(1H,3H)-dione pubchem
small molecule Agonist dopamine, noradrenaline, 5-hydroxytryptamine small molecule - - 2021-04-14
Gq/11 αq Human - 63 β1 Human γ2 Human cryo-EM 7EZM - 2.9 CCKAR CCK1 Cholecystokinin A (Rhodopsin) Human - scFv16 Gq Cholecystokinin-8 pubchem chembl_ligand
peptide Agonist CCK-58, CCK-39, CCK-4, CCK-8, CCK-33, gastrin-17 protein - - 2021-08-25
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 7EZK 7EZK_refined 3.1 CCKAR CCK1 Cholecystokinin A (Rhodopsin) Human - - - Cholecystokinin-8 pubchem chembl_ligand
peptide Agonist CCK-58, CCK-39, CCK-4, CCK-8, CCK-33, gastrin-17 protein - - 2021-08-25
Gi/o αi1 Human - 95 β1 Human γT1 Human cryo-EM 7L0Q 7L0Q_refined 4.3 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat - - - neurotensin pubchem
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide - - 2021-01-06
Gi/o αi1 Human Non-canonical conformation 63 β1 Human γT1 Human cryo-EM 7L0R 7L0R_refined 4.2 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat - - - neurotensin pubchem
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide - - 2021-01-06
Gi/o αi1 Human - 61 β1 Human γ2 Human cryo-EM 7EZH 7EZH_refined 3.2 CCKAR CCK1 Cholecystokinin A (Rhodopsin) Human - scFv16 - Cholecystokinin-8 pubchem chembl_ligand
peptide Agonist CCK-58, CCK-39, CCK-4, CCK-8, CCK-33, gastrin-17 protein - - 2021-08-25
Gs αs Human - 58 β1 Human γ2 Human cryo-EM 7D7M 7D7M_refined 3.3 PE2R4 EP4 Prostanoid A (Rhodopsin) Human - Nanobody-35 - Prostaglandin E2 pubchem chembl_ligand
small molecule Agonist PGE1, PGD2, PGE2, PGF2α, PGI2 small molecule - - 2020-11-18
Gs αs Human - 61 β1 Rat γ2 Human cryo-EM 7MBX 7MBX_refined 2.0 CCKAR CCK1 Cholecystokinin A (Rhodopsin) Human - Nanobody-35 - Cholecystokinin-8 pubchem chembl_ligand
peptide Agonist CCK-58, CCK-39, CCK-4, CCK-8, CCK-33, gastrin-17 protein - - 2021-05-26
Gq/11 αq Human Gq-Gs-Gi1 chimera 57 β1 Rat γ2 Human cryo-EM 7MBY 7MBY_refined 2.4 CCKAR CCK1 Cholecystokinin A (Rhodopsin) Human - - Gq Cholecystokinin-8 pubchem chembl_ligand
peptide Agonist CCK-58, CCK-39, CCK-4, CCK-8, CCK-33, gastrin-17 protein - - 2021-05-26
Gq/11 αq Human - 63 β1 Human γ2 Human cryo-EM 7DFL 7DFL_refined 3.3 HRH1 H1 Histamine A (Rhodopsin) Human - scFv16 Gq histamine pubchem
small molecule Agonist histamine small molecule - - 2021-03-31
Gs αs Human - 96 - - - - X-ray 7BPH - 1.6 - - - - - - - - - - - - - - - 2021-03-31
Gs αs Bovine - 100 - - - - X-ray 3G82 - 3.1 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - - - 2010-02-16
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 7EW3 - 3.1 - - - - - - - Sphingosine 1-phosphate receptor 3
scFV16 		- - - - - - - 2021-09-29
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 7EW4 - 3.2 - - - - - - - Sphingosine 1-phosphate receptor 3
scFV16 		- - - - - - - 2021-09-29
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 7EW2 - 3.1 - - - - - - - scFV16
Sphingosine 1-phosphate receptor 3 		- - - - - - - 2021-09-29
Gi/o αi1 Human - 100 - - - - X-ray 3UMS - 2.3 - - - - - - - - - - - - - - - 2012-02-08
Gi/o αi1 Human - 100 - - - - X-ray 3UMR - 2.0 - - - - - - - - - - - - - - - 2012-10-24
Gi/o αi1 Human - 93 - - - - X-ray 4G5Q - 2.9 - - - - - - - G-protein-signaling modulator 2 - - - - - - - 2012-09-05
Gi/o αi1 Rat - 100 - - - - X-ray 2ZJZ - 2.6 - - - - - - - - - - - - - - - 2009-03-24
Gi/o αi1 Rat - 100 - - - - X-ray 2ZJY - 2.8 - - - - - - - - - - - - - - - 2009-03-24
Gi/o αi1 Rat - 100 - - - - X-ray 6M8H - 2.1 - - - - - - - - - - - - - - - 2019-08-21
Gi/o αi2 Human - 100 β1 Human γ2 Human cryo-EM 7LD3 - 3.2 - - - - - - - - - - - - - - - 2021-09-08
Gi/o αi2 Human - 100 β1 Human γ2 Human cryo-EM 7LD4 - 3.3 - - - - - - - - - - - - - - - 2021-09-08
Gi/o αi3 Human - 93 - - - - X-ray 4G5R - 3.5 - - - - - - - G-protein-signaling modulator 2 - - - - - - - 2012-09-05
Gi/o αi3 Human - 93 - - - - X-ray 4G5S - 3.6 - - - - - - - G-protein-signaling modulator 2 - - - - - - - 2012-09-05
Gi/o αi3 Human - 93 - - - - X-ray 4G5O - 2.9 - - - - - - - G-protein-signaling modulator 2 - - - - - - - 2012-09-05
Gi/o αt2 Bovine - 3 - - - - X-ray 6PH7 - 2.9 - - - - - - - Rhodopsin - - - - - - - 2020-07-01
Gi/o αt2 Bovine - 3 - - - - X-ray 6PGS - 2.9 - - - - - - - Rhodopsin - - - - - - - 2020-07-01
Gs αs Human - 96 - - - - X-ray 6AU6 - 1.7 - - - - - - - - - - - - - Hu Q, Shokat KM 29628140 2018-05-09
Gs αs Human - 100 - - - - X-ray 6E67 - 3.7 - - - - - - - - - - - - - Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixa-Gonzalez R, Mathiesen JM, Hildebrand PW, Kobilka BK 31080070 2019-06-05
Gs αs Human - 97 β1 Human γ2 Human X-ray 6EG8 - 2.8 - - - - - - - - - - - - - Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixa-Gonzalez R, Mathiesen JM, Hildebrand PW, Kobilka BK 31080070 2019-06-05
Gs αs Human - 100 β1 Human γ2 Human cryo-EM 7RTB - 2.1 - - - - - - - Nb35
Glucagon-like peptide 1 receptor
Peptide-19 		- - - - - Johnson RM, Zhang X, Piper SJ, Nettleton TJ, Vandekolk TH, Langmead CJ, Danev R, Sexton PM, Wootten D 34547628 2021-10-06
Gs αs Bovine - 100 - - - - X-ray 1AZT - 2.3 - - - - - - - - - - - - - Sunahara RK, Tesmer JJ, Gilman AG, Sprang SR 9395396 1998-02-25
Gs αs Bovine - 100 - - - - X-ray 1AZS - 2.3 - - - - - - - VC1
IIC2 		- - - - - Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR 9417641 1998-02-25
Gs αs Bovine - 100 - - - - X-ray 1U0H - 2.9 - - - - - - - Adenylate cyclase
type V
Adenylate cyclase
type II 		- - - - - Mou TC, Gille A, Fancy DA, Seifert R, Sprang SR 15591060 2004-12-14
Gs αs Bovine - 100 - - - - X-ray 1CJK - 3.0 - - - - - - - Adenylate cyclase
type V
ADENYLATE CYCLASE
TYPE II 		- - - - - Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR 10427002 1999-08-31
Gs αs Bovine - 100 - - - - X-ray 1CJV - 3.0 - - - - - - - Adenylate cyclase
type V
ADENYLATE CYCLASE
TYPE II 		- - - - - Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR 10427002 1999-08-31
Gs αs Bovine - 100 - - - - X-ray 1CJU - 2.8 - - - - - - - Adenylate cyclase
type V
ADENYLATE CYCLASE
TYPE II 		- - - - - Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR 10427002 1999-08-31
Gs αs Bovine - 100 - - - - X-ray 1CJT - 2.8 - - - - - - - Adenylate cyclase
type V
ADENYLATE CYCLASE
TYPE II 		- - - - - Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR 10427002 1999-08-31
Gs αs Bovine - 100 - - - - X-ray 1CS4 - 2.5 - - - - - - - TYPE V ADENYLATE CYCLASE
TYPE II ADENYLATE CYCLASE 		- - - - - Tesmer JJ, Dessauer CW, Sunahara RK, Murray LD, Johnson RA, Gilman AG, Sprang SR 11087399 2001-01-10
Gs αs Bovine - 96 - - - - X-ray 1CUL - 2.4 - - - - - - - TYPE V ADENYLYL CYCLASE
TYPE II ADENYLYL CYCLASE 		- - - - - Tesmer JJ, Dessauer CW, Sunahara RK, Murray LD, Johnson RA, Gilman AG, Sprang SR 11087399 2001-01-10
Gs αs Bovine - 100 - - - - X-ray 2GVZ - 3.3 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - Mou TC, Gille A, Suryanarayana S, Richter M, Seifert R, Sprang SR 16766715 2006-07-04
Gs αs Bovine - 100 - - - - X-ray 2GVD - 2.9 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - Mou TC, Gille A, Suryanarayana S, Richter M, Seifert R, Sprang SR 16766715 2006-07-04
Gs αs Bovine - 100 - - - - X-ray 3C14 - 2.7 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - Mou TC, Masada N, Cooper DM, Sprang SR 19243146 2009-02-03
Gs αs Bovine - 100 - - - - X-ray 3C15 - 2.8 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - Mou TC, Masada N, Cooper DM, Sprang SR 19243146 2009-02-03
Gs αs Bovine - 100 - - - - X-ray 3C16 - 2.9 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - Mou TC, Masada N, Cooper DM, Sprang SR 19243146 2009-02-03
Gs αs Bovine - 100 - - - - X-ray 3MAA - 3.0 - - - - - - - Adenylate cyclase type 5
Adenylate cyclase type 2 		- - - - - Mou TC, Masada N, Cooper DM, Sprang SR 19243146 2010-04-07
Gs αs Bovine - 100 - - - - cryo-EM 6R3Q - 3.4 - - - - - - - Adenylate cyclase 9 - - - - - Qi C, Sorrentino S, Medalia O, Korkhov VM 31023924 2019-05-08
Gs αs Bovine - 100 - - - - cryo-EM 6R4P - 3.1 - - - - - - - Adenylate cyclase 9 - - - - - Qi C, Sorrentino S, Medalia O, Korkhov VM 31023924 2019-05-08
Gs αs Bovine - 100 - - - - cryo-EM 6R4O - 4.2 - - - - - - - Adenylate cyclase 9 - - - - - Qi C, Sorrentino S, Medalia O, Korkhov VM 31023924 2019-05-08
Gs αs Bovine - 100 - - - - X-ray 1TL7 - 2.8 - - - - - - - Adenylate cyclase
type V
Adenylate cyclase
type II 		- - - - - Mou TC, Gille A, Fancy DA, Seifert R, Sprang SR 15591060 2004-12-14
Gi/o αi1 Human - 88 - - - - X-ray 2G83 - 2.8 - - - - - - - KB-1753 phage display peptide - - - - - Johnston CA, Lobanova ES, Shavkunov AS, Low J, Ramer JK, Blaesius R, Fredericks Z, Willard FS, Kuhlman B, Arshavsky VY, Siderovski DP 16981699 2006-10-10
Gi/o αi1 Human - 92 - - - - X-ray 2OM2 - 2.2 - - - - - - - Regulator of G-protein signalling 14 GoLoco motif peptide - - - - - Sammond DW, Eletr ZM, Purbeck C, Kimple RJ, Siderovski DP, Kuhlman B 17603074 2007-07-10
Gi/o αi1 Human - 91 - - - - X-ray 2GTP - 2.6 - - - - - - - Regulator of G-protein signaling 1 - - - - - Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP 18434541 2006-05-23
Gi/o αi1 Human - 92 - - - - X-ray 2IK8 - 2.7 - - - - - - - Regulator of G-protein signaling 16 - - - - - Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP 18434541 2006-11-21
Gi/o αi1 Human - 100 - - - - cryo-EM 6VU8 - 4.1 - - - - - - - Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) - - - - - Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G 32126208 2020-03-18
Gi/o αi1 Human - 93 - - - - X-ray 1Y3A - 2.5 - - - - - - - KB752 peptide - - - - - Johnston CA, Willard FS, Jezyk MR, Fredericks Z, Bodor ET, Jones MB, Blaesius R, Watts VJ, Harden TK, Sondek J, Ramer JK, Siderovski DP 16004878 2005-07-12
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 7EVZ - 3.1 - - - - - - scFv16 Sphingosine 1-phosphate receptor 1 - - - - - Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z 34526663 2021-09-29
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 7EVY - 3.0 - - - - - - scFv16 Sphingosine 1-phosphate receptor 1 - - - - - Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z 34526663 2021-09-29
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 7EW1 - 3.4 - - - - - - scFv16 Sphingosine 1-phosphate receptor 5 - - - - - Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z 34526663 2021-09-29
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 7EW7 - 3.3 - - - - - - scFv16 Sphingosine 1-phosphate receptor 1 - - - - - Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z 34526663 2021-09-29
Gi/o αi1 Human - 100 β1 Human γ2 Human cryo-EM 7EW0 - 3.4 - - - - - - scFv16 Sphingosine 1-phosphate receptor 1 - - - - - Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z 34526663 2021-09-29
Gi/o αi1 Human - 92 - - - - X-ray 2XNS - 3.4 - - - - - - - Regulator of G-protein signaling 14 - - - - - Sammond DW, Bosch DE, Butterfoss GL, Purbeck C, Machius M, Siderovski DP, Kuhlman B 21388199 2011-06-08
Gi/o αi1 Human - 93 - - - - X-ray 3ONW - 2.4 - - - - - - - Regulator of G-protein signaling 14 - - - - - Bosch DE, Kimple AJ, Sammond DW, Muller RE, Miley MJ, Machius M, Kuhlman B, Willard FS, Siderovski DP 21115486 2010-11-24
Gi/o αi1 Human - 93 - - - - X-ray 3QI2 - 2.8 - - - - - - - Regulator of G-protein signaling 14 - - - - - Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP 22383884 2012-02-01
Gi/o αi1 Human - 92 - - - - X-ray 3QE0 - 3.0 - - - - - - - KB752 peptide - - - - - Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP 22383884 2012-01-25
Gi/o αi1 Human - 100 β1 Human γ2 Human X-ray 6CRK - 2.0 - - - - - - single-chain Fv - - - - - - Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK 30213947 2018-10-24
Gi/o αi1 Human - 100 β1 Rat γ2 Bovine X-ray 5TDH - 3.0 - - - - - - - - - - - - - Liu P, Jia MZ, Zhou XE, De Waal PW, Dickson BM, Liu B, Hou L, Yin YT, Kang YY, Shi Y, Melcher K, Xu HE, Jiang Y 27498775 2016-11-09
Gi/o αi1 Human - 92 - - - - X-ray 1KJY - 2.7 - - - - - - - Regulator of G-protein signaling 14 - - - - - Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP 11976690 2002-05-08
Gi/o αi1 Rat - 100 - - - - X-ray 2RGN - 3.5 - - - - - - - Rho guanine nucleotide exchange factor 25
Transforming protein RhoA 		- - - - - Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ 18096806 2008-01-15
Gi/o αi1 Rat - 100 - - - - X-ray 1AGR - 2.8 - - - - - - - RGS4 - - - - - Tesmer JJ, Berman DM, Gilman AG, Sprang SR 9108480 1997-06-16
Gi/o αi1 Rat - 100 - - - - X-ray 1AS3 - 2.4 - - - - - - - - - - - - - Raw AS, Coleman DE, Gilman AG, Sprang SR 9398294 1997-11-12
Gi/o αi1 Rat - 100 - - - - X-ray 1AS2 - 2.8 - - - - - - - - - - - - - Raw AS, Coleman DE, Gilman AG, Sprang SR 9398294 1997-11-12
Gi/o αi1 Rat - 100 - - - - X-ray 1AS0 - 2.0 - - - - - - - - - - - - - Raw AS, Coleman DE, Gilman AG, Sprang SR 9398294 1997-11-12
Gi/o αi1 Rat - 89 - - - - X-ray 1BH2 - 2.1 - - - - - - - - - - - - - Posner BA, Mixon MB, Wall MA, Sprang SR, Gilman AG 9705312 1998-11-04
Gi/o αi1 Rat - 100 - - - - X-ray 1BOF - 2.2 - - - - - - - - - - - - - Coleman DE, Sprang SR 9772163 1999-01-06
Gi/o αi1 Rat - 100 - - - - X-ray 1CIP - 1.5 - - - - - - - - - - - - - Coleman DE, Sprang SR 10358003 1999-04-09
Gi/o αi1 Rat - 96 - - - - X-ray 1SHZ - 2.9 - - - - - - - Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera
Rho guanine nucleotide exchange factor 1 		- - - - - Chen Z, Singer WD, Sternweis PC, Sprang SR 15665872 2005-01-18
Gi/o αi1 Rat - 100 - - - - X-ray 1SVK - 2.0 - - - - - - - - - - - - - Thomas CJ, Du X, Li P, Wang Y, Ross EM, Sprang SR 15128951 2004-06-01
Gi/o αi1 Rat - 100 - - - - X-ray 1SVS - 1.5 - - - - - - - - - - - - - Thomas CJ, Du X, Li P, Wang Y, Ross EM, Sprang SR 15128951 2004-06-01
Gi/o αi1 Rat - 92 - - - - X-ray 1FQK - 2.3 - - - - - - - Regulator of G-protein signaling 9 - - - - - Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB 11234020 2001-02-28
Gi/o αi1 Rat - 92 - - - - X-ray 1FQJ - 2.0 - - - - - - - Regulator of G-protein signaling 9 - - - - - Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB 11234020 2001-02-28
Gi/o αi1 Rat - 100 - - - - X-ray 1GDD - 2.2 - - - - - - - - - - - - - Mixon MB, Lee E, Coleman DE, Berghuis AM, Gilman AG, Sprang SR 7481799 1995-11-27
Gi/o αi1 Rat - 100 - - - - X-ray 1GFI - 2.2 - - - - - - - - - - - - - Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR 8073283 1995-03-31
Gi/o αi1 Rat - 100 β1 Bovine γ2 Bovine X-ray 1GG2 - 2.4 - - - - - - - - - - - - - Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR 8521505 1997-02-12
Gi/o αi1 Rat - 100 - - - - X-ray 1GIL - 2.3 - - - - - - - - - - - - - Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR 8073283 1995-02-14
Gi/o αi1 Rat - 100 - - - - X-ray 1GIA - 2.0 - - - - - - - - - - - - - Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR 8073283 1994-09-30
Gi/o αi1 Rat - 100 - - - - X-ray 1GIT - 2.6 - - - - - - - - - - - - - Berghuis AM, Lee E, Raw AS, Gilman AG, Sprang SR 8939752 1997-02-12
Gi/o αi1 Rat - 100 β1 Bovine γ2 Bovine X-ray 1GP2 - 2.3 - - - - - - - - - - - - - Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR 8521505 1997-02-12
Gi/o αi1 Rat - 100 - - - - X-ray 5KDL - 2.7 - - - - - - - - - - - - - Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE 27462082 2016-08-03
Gi/o αi1 Rat - 100 β1 Bovine γT1 Bovine X-ray 5KDO - 1.9 - - - - - - - - - - - - - Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE 27462082 2016-08-03
Gi/o αi1 Rat - 100 β1 Bovine γ2 Bovine X-ray 3AH8 - 2.9 - - - - - - - YM-254890 - - - - - Nishimura A, Kitano K, Takasaki J, Taniguchi M, Mizuno N, Tago K, Hakoshima T, Itoh H 20639466 2010-07-21
Gi/o αi1 Rat - 100 - - - - X-ray 3FFA - 2.3 - - - - - - - - - - - - - Kapoor N, Menon ST, Chauhan R, Sachdev P, Sakmar TP 19703466 2009-10-06
Gi/o αi1 Rat - 100 - - - - X-ray 3FFB - 2.6 - - - - - - - - - - - - - Kapoor N, Menon ST, Chauhan R, Sachdev P, Sakmar TP 19703466 2009-10-06
Gi/o αi1 Rat - 100 - - - - X-ray 3D7M - 2.9 - - - - - - - - - - - - - Preininger AM, Funk MA, Oldham WM, Meier SM, Johnston CA, Adhikary S, Kimple AJ, Siderovski DP, Hamm HE, Iverson TM 19222191 2009-03-03
Gi/o αi1 Rat - 91 - - - - cryo-EM 6UKT - 3.9 - - - - - - NB8109
NB8117
NB8119
NB9156 		Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) - - - - - McClelland LJ, Zhang K, Mou TC, Johnston J, Yates-Hansen C, Li S, Thomas CJ, Doukov TI, Triest S, Wohlkonig A, Tall GG, Steyaert J, Chiu W, Sprang SR 32103024 2020-03-11
Gi/o αi1 Rat - 100 - - - - X-ray 6TYL - 3.3 - - - - - - Nanobody A
Nanobody B
Nanobody C 		Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) - - - - - McClelland LJ, Zhang K, Mou TC, Johnston J, Yates-Hansen C, Li S, Thomas CJ, Doukov TI, Triest S, Wohlkonig A, Tall GG, Steyaert J, Chiu W, Sprang SR 32103024 2020-03-11
Gi/o αi1 Rat - 100 - - - - X-ray 4PAM - 2.1 - - - - - - - - - - - - - Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE 25037222 2014-07-30
Gi/o αi1 Rat - 100 - - - - X-ray 4PAN - 2.4 - - - - - - - - - - - - - Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE 25037222 2014-07-30
Gi/o αi1 Rat - 100 - - - - X-ray 4PAO - 2.0 - - - - - - - - - - - - - Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE 25037222 2014-07-30
Gi/o αi1 Rat - 100 - - - - X-ray 4PAQ - 2.0 - - - - - - - - - - - - - Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE 25037222 2014-07-30
Gi/o αi1 Rat - 100 - - - - X-ray 4N0D - 1.6 - - - - - - - - - - - - - Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM 24596087 2014-03-12
Gi/o αi1 Rat - 100 - - - - X-ray 4N0E - 2.1 - - - - - - - - - - - - - Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM 24596087 2014-03-12
Gi/o αi1 Rat - 100 - - - - X-ray 3V00 - 2.9 - - - - - - - - - - - - - Singh G, Ramachandran S, Cerione RA 22448927 2012-04-18
Gi/o αi1 Rat - 100 β1 Bovine γ2 Bovine X-ray 2BCJ - 3.1 - - - - - - - G-protein-coupled receptor kinase 2 - - - - - Tesmer VM, Kawano T, Shankaranarayanan A, Kozasa T, Tesmer JJ 16339447 2005-12-20
Gi/o αi3 Human - 99 - - - - X-ray 2ODE - 1.9 - - - - - - - Regulator of G-protein signaling 8 - - - - - Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP 18434541 2007-02-06
Gi/o αi3 Human - 91 - - - - X-ray 2IHB - 2.7 - - - - - - - Regulator of G-protein signalling 10 - - - - - Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP 18434541 2006-11-21
Gi/o αi3 Human - 99 - - - - X-ray 2V4Z - 2.8 - - - - - - - REGULATOR OF G-PROTEIN SIGNALING 2 - - - - - Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP 19478087 2008-11-04
Gi/o αi3 Rat - 99 - - - - X-ray 6MHF - 2.0 - - - - - - - Girdin - - - - - Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I 31363053 2019-07-31
Gi/o αi3 Rat - 99 - - - - X-ray 6MHE - 2.2 - - - - - - - KB752 peptide - - - - - Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I 31363053 2019-07-31
Gi/o αt1 Human - 3 - - - - X-ray 3RBQ - 2.0 - - - - - - - Protein unc-119 homolog A - - - - - Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W 21642972 2011-06-08
Gi/o αt1 Bovine - 93 - - - - X-ray 1TND - 2.2 - - - - - - - - - - - - - Noel JP, Hamm HE, Sigler PB 8259210 1994-07-31
Gi/o αt1 Bovine - 100 - - - - cryo-EM 7JSN - 3.2 - - - - - - - Rod cGMP-specific 3'
5'-cyclic phosphodiesterase subunit alpha
Rod cGMP-specific 3'
5'-cyclic phosphodiesterase subunit beta 		- - - - - Gao Y, Eskici G, Ramachandran S, Poitevin F, Seven AB, Panova O, Skiniotis G, Cerione RA 33007200 2020-10-21
Gi/o αt1 Bovine - 93 - - - - X-ray 1TAD - 1.7 - - - - - - - - - - - - - Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB 7969474 1995-05-08
Gi/o αt1 Bovine - 93 - - - - X-ray 1TAG - 1.8 - - - - - - - - - - - - - Lambright DG, Noel JP, Hamm HE, Sigler PB 8208289 1995-02-07
Gi/o αt1 Bovine - 100 β1 Bovine γT1 Bovine X-ray 1GOT - 2.0 - - - - - - - - - - - - - Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB 8552184 1997-03-12
Gi/o αt1 Bovine - 3 - - - - X-ray 2X72 - 3.0 - - - - - - - RHODOPSIN - - - - - Standfuss J, Edwards PC, D'Antona A, Fransen M, Xie G, Oprian DD, Schertler GF 21389983 2011-03-16
Gi/o αt1 Bovine - 3 - - - - X-ray 3PQR - 2.9 - - - - - - - Rhodopsin - - - - - Choe HW, Kim YJ, Park JH, Morizumi T, Pai EF, Krauss N, Hofmann KP, Scheerer P, Ernst OP 21389988 2011-03-09
Gi/o αt1 Bovine - 3 - - - - X-ray 4A4M - 3.3 - - - - - - - RHODOPSIN - - - - - Deupi X, Edwards P, Singhal A, Nickle B, Oprian D, Schertler G, Standfuss J 22198838 2012-01-25
Gi/o αt1 Bovine - 3 - - - - X-ray 4BEY - 2.9 - - - - - - - Rhodopsin - - - - - Singhal A, Ostermaier MK, Vishnivetskiy SA, Panneels V, Homan KT, Tesmer JJ, Veprintsev D, Deupi X, Gurevich VV, Schertler GF, Standfuss J 23579341 2013-05-08
Gi/o αt1 Bovine - 3 - - - - X-ray 4J4Q - 2.7 - - - - - - - Rhodopsin - - - - - Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP 24038729 2013-10-30
Gi/o αt1 Bovine - 3 - - - - X-ray 3DQB - 3.2 - - - - - - - Rhodopsin - - - - - Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW, Hofmann KP, Ernst OP 18818650 2008-09-23
Gi/o αt2 Human - 100 - - - - X-ray 6N85 - 2.5 - - - - - - - Synembryn-A - - - - - Srivastava D, Gakhar L, Artemyev NO 31300652 2019-07-10
Gi/o αt2 Human - 100 - - - - X-ray 6N84 - 1.8 - - - - - - - - - - - - - Srivastava D, Gakhar L, Artemyev NO 31300652 2019-07-10
Gi/o αo Mouse - 94 - - - - X-ray 3C7K - 2.9 - - - - - - - Regulator of G-protein signaling 16 - - - - - Slep KC, Kercher MA, Wieland T, Chen CK, Simon MI, Sigler PB 18434540 2008-05-06
Gq/11 αq Human - 100 - - - - cryo-EM 6VU5 - 3.5 - - - - - - - Resistance to inhibitors of cholinesterase-8A (Ric-8A) - - - - - Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G 32126208 2020-03-18
Gq/11 αq Mouse - 100 - - - - X-ray 4QJ5 - 3.4 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3 		- - - - - Lyon AM, Begley JA, Manett TD, Tesmer JJG 25435326 2014-10-22
Gq/11 αq Mouse - 100 - - - - X-ray 4QJ3 - 3.0 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3 		- - - - - Lyon AM, Begley JA, Manett TD, Tesmer JJG 25435326 2014-10-22
Gq/11 αq Mouse - 100 - - - - X-ray 4QJ4 - 3.3 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3 		- - - - - Lyon AM, Begley JA, Manett TD, Tesmer JJG 25435326 2014-10-22
Gq/11 αq Mouse - 91 - - - - X-ray 3OHM - 2.7 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3 		- - - - - Waldo GL, Ricks TK, Hicks SN, Cheever ML, Kawano T, Tsuboi K, Wang X, Montell C, Kozasa T, Sondek J, Harden TK 20966218 2010-10-27
Gq/11 αq Mouse - 97 - - - - X-ray 4EKC - 7.4 - - - - - - - Regulator of G-protein signaling 2 - - - - - Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, Tesmer JJ 23434405 2013-01-30
Gq/11 αq Mouse - 97 - - - - X-ray 4EKD - 2.7 - - - - - - - Regulator of G-protein signaling 2 - - - - - Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, Tesmer JJ 23434405 2013-01-30
Gq/11 αq Mouse - 87 - - - - X-ray 5DO9 - 2.6 - - - - - - - Regulator of G-protein signaling 8 - - - - - Taylor VG, Bommarito PA, Tesmer JJ 26755720 2016-01-20
Gq/11 αq Mouse - 98 - - - - X-ray 4GNK - 4.0 - - - - - - - 1-phosphatidylinositol 4
5-bisphosphate phosphodiesterase beta-3 		- - - - - Lyon AM, Dutta S, Boguth CA, Skiniotis G, Tesmer JJ 23377541 2013-02-06
G12/13 α12 Mouse - 95 - - - - X-ray 1ZCA - 2.9 - - - - - - - - - - - - - Kreutz B, Yau DM, Nance MR, Tanabe S, Tesmer JJ, Kozasa T 16388592 2005-11-15
G12/13 α13 Mouse - 96 - - - - X-ray 1ZCB - 2.0 - - - - - - - - - - - - - Kreutz B, Yau DM, Nance MR, Tanabe S, Tesmer JJ, Kozasa T 16388592 2005-11-15
G12/13 α13 Mouse - 96 - - - - X-ray 3AB3 - 2.4 - - - - - - - Rho guanine nucleotide exchange factor 1 - - - - - Hajicek N, Kukimoto-Niino M, Mishima-Tsumagari C, Chow CR, Shirouzu M, Terada T, Patel M, Yokoyama S, Kozasa T 21507947 2010-12-29
G12/13 α13 Mouse - 90 - - - - X-ray 3CX8 - 2.0 - - - - - - - Rho guanine nucleotide exchange factor 11 - - - - - Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR 18940608 2008-10-28
G12/13 α13 Mouse - 90 - - - - X-ray 3CX6 - 2.5 - - - - - - - Rho guanine nucleotide exchange factor 11 - - - - - Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR 18940608 2008-10-28
G12/13 α13 Mouse - 90 - - - - X-ray 3CX7 - 2.3 - - - - - - - Glutamate Transporter Associated Protein 48 - - - - - Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR 18940608 2008-10-28
«

Versions

Package Name Version
Django 2.2.1
Python 3.6.7
debug_toolbar Debug Toolbar 1.11
polymorphic Polymorphic 2.0.3
rest_framework Django REST framework 3.9.3
rest_framework_swagger Rest_Framework_Swagger 2.2.0

Time

Resource usage

Resource Value
User CPU time 7311.733 msec
System CPU time 316.298 msec
Total CPU time 7628.031 msec
Elapsed time 8694.971 msec
Context switches 4583 voluntary, 187 involuntary

Browser timing

Timing attribute Timeline Milliseconds since navigation start (+length)

Settings from protwis.settings

Setting Value
ABSOLUTE_URL_OVERRIDES {}
ADMINS []
ALLOWED_HOSTS ['*']
APPEND_SLASH True
AUTHENTICATION_BACKENDS ['django.contrib.auth.backends.ModelBackend']
AUTH_PASSWORD_VALIDATORS '********************'
AUTH_USER_MODEL 'auth.User'
BASE_DIR '/home/protwis/gpcrdb_test'
BUILD_CACHE_DIR '/home/protwis/gpcrdb_data/cache'
CACHES {'alignments': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test_alignment', 'OPTIONS': {'MAX_ENTRIES': 1000}}, 'default': {'BACKEND': 'django.core.cache.backends.filebased.FileBasedCache', 'LOCATION': '/home/protwis/caches/test/', 'OPTIONS': {'MAX_ENTRIES': 10000000}}}
CACHE_MIDDLEWARE_ALIAS 'default'
CACHE_MIDDLEWARE_KEY_PREFIX '********************'
CACHE_MIDDLEWARE_SECONDS 600
CSRF_COOKIE_AGE 31449600
CSRF_COOKIE_DOMAIN None
CSRF_COOKIE_HTTPONLY False
CSRF_COOKIE_NAME 'csrftoken'
CSRF_COOKIE_PATH '/'
CSRF_COOKIE_SAMESITE 'Lax'
CSRF_COOKIE_SECURE False
CSRF_FAILURE_VIEW 'django.views.csrf.csrf_failure'
CSRF_HEADER_NAME 'HTTP_X_CSRFTOKEN'
CSRF_TRUSTED_ORIGINS []
CSRF_USE_SESSIONS False
DATABASES {'default': {'ATOMIC_REQUESTS': False, 'AUTOCOMMIT': True, 'CONN_MAX_AGE': 0, 'ENGINE': 'django.db.backends.postgresql_psycopg2', 'HOST': 'localhost', 'NAME': 'protwis_202107', 'OPTIONS': {}, 'PASSWORD': '********************', 'PORT': '', 'TEST': {'CHARSET': None, 'COLLATION': None, 'MIRROR': None, 'NAME': None}, 'TIME_ZONE': None, 'USER': 'protwis'}}
DATABASE_ROUTERS []
DATA_DIR '/home/protwis/gpcrdb_data'
DATA_UPLOAD_MAX_MEMORY_SIZE 2621440
DATA_UPLOAD_MAX_NUMBER_FIELDS 1000
DATETIME_FORMAT 'N j, Y, P'
DATETIME_INPUT_FORMATS ['%Y-%m-%d %H:%M:%S', '%Y-%m-%d %H:%M:%S.%f', '%Y-%m-%d %H:%M', '%Y-%m-%d', '%m/%d/%Y %H:%M:%S', '%m/%d/%Y %H:%M:%S.%f', '%m/%d/%Y %H:%M', '%m/%d/%Y', '%m/%d/%y %H:%M:%S', '%m/%d/%y %H:%M:%S.%f', '%m/%d/%y %H:%M', '%m/%d/%y']
DATE_FORMAT 'N j, Y'
DATE_INPUT_FORMATS ['%Y-%m-%d', '%m/%d/%Y', '%m/%d/%y', '%b %d %Y', '%b %d, %Y', '%d %b %Y', '%d %b, %Y', '%B %d %Y', '%B %d, %Y', '%d %B %Y', '%d %B, %Y']
DEBUG True
DEBUG_PROPAGATE_EXCEPTIONS False
DEBUG_TOOLBAR_PATCH_SETTINGS False
DECIMAL_SEPARATOR '.'
DEFAULT_CHARSET 'utf-8'
DEFAULT_CONTENT_TYPE 'text/html'
DEFAULT_EXCEPTION_REPORTER_FILTER 'django.views.debug.SafeExceptionReporterFilter'
DEFAULT_FILE_STORAGE 'django.core.files.storage.FileSystemStorage'
DEFAULT_FROM_EMAIL 'webmaster@localhost'
DEFAULT_INDEX_TABLESPACE ''
DEFAULT_NUMBERING_SCHEME 'gpcrdb'
DEFAULT_PROTEIN_STATE 'inactive'
DEFAULT_SITE 'gpcr'
DEFAULT_TABLESPACE ''
DISALLOWED_USER_AGENTS []
DOCUMENTATION_URL 'https://docs.gpcrdb.org/'
EMAIL_BACKEND 'django.core.mail.backends.smtp.EmailBackend'
EMAIL_HOST 'localhost'
EMAIL_HOST_PASSWORD '********************'
EMAIL_HOST_USER ''
EMAIL_PORT 25
EMAIL_SSL_CERTFILE None
EMAIL_SSL_KEYFILE '********************'
EMAIL_SUBJECT_PREFIX '[Django] '
EMAIL_TIMEOUT None
EMAIL_USE_LOCALTIME False
EMAIL_USE_SSL False
EMAIL_USE_TLS False
FILE_CHARSET 'utf-8'
FILE_UPLOAD_DIRECTORY_PERMISSIONS None
FILE_UPLOAD_HANDLERS ['django.core.files.uploadhandler.MemoryFileUploadHandler', 'django.core.files.uploadhandler.TemporaryFileUploadHandler']
FILE_UPLOAD_MAX_MEMORY_SIZE 2621440
FILE_UPLOAD_PERMISSIONS None
FILE_UPLOAD_TEMP_DIR None
FIRST_DAY_OF_WEEK 0
FIXTURE_DIRS []
FORCE_SCRIPT_NAME None
FORMAT_MODULE_PATH None
FORM_RENDERER 'django.forms.renderers.DjangoTemplates'
GOOGLE_ANALYTICS_API '********************'
GOOGLE_ANALYTICS_KEY '********************'
IGNORABLE_404_URLS []
INSTALLED_APPS ('django.contrib.admin', 'django.contrib.auth', 'django.contrib.contenttypes', 'django.contrib.sessions', 'django.contrib.messages', 'django.contrib.staticfiles', 'django.contrib.humanize', 'debug_toolbar', 'rest_framework', 'rest_framework_swagger', 'polymorphic', 'common', 'api', 'news', 'pages', 'home', 'protein', 'family', 'residue', 'alignment', 'similaritysearch', 'similaritymatrix', 'structure', 'ligand', 'interaction', 'mutation', 'phylogenetic_trees', 'sitesearch', 'build_gpcr', 'construct', 'tools', 'drugs', 'signprot', 'signprot2', 'mutational_landscape', 'contactnetwork', 'seqsign', 'angles', 'hotspots')
INTERNAL_IPS '10.0.2.2'
LANGUAGES [('af', 'Afrikaans'), ('ar', 'Arabic'), ('ast', 'Asturian'), ('az', 'Azerbaijani'), ('bg', 'Bulgarian'), ('be', 'Belarusian'), ('bn', 'Bengali'), ('br', 'Breton'), ('bs', 'Bosnian'), ('ca', 'Catalan'), ('cs', 'Czech'), ('cy', 'Welsh'), ('da', 'Danish'), ('de', 'German'), ('dsb', 'Lower Sorbian'), ('el', 'Greek'), ('en', 'English'), ('en-au', 'Australian English'), ('en-gb', 'British English'), ('eo', 'Esperanto'), ('es', 'Spanish'), ('es-ar', 'Argentinian Spanish'), ('es-co', 'Colombian Spanish'), ('es-mx', 'Mexican Spanish'), ('es-ni', 'Nicaraguan Spanish'), ('es-ve', 'Venezuelan Spanish'), ('et', 'Estonian'), ('eu', 'Basque'), ('fa', 'Persian'), ('fi', 'Finnish'), ('fr', 'French'), ('fy', 'Frisian'), ('ga', 'Irish'), ('gd', 'Scottish Gaelic'), ('gl', 'Galician'), ('he', 'Hebrew'), ('hi', 'Hindi'), ('hr', 'Croatian'), ('hsb', 'Upper Sorbian'), ('hu', 'Hungarian'), ('hy', 'Armenian'), ('ia', 'Interlingua'), ('id', 'Indonesian'), ('io', 'Ido'), ('is', 'Icelandic'), ('it', 'Italian'), ('ja', 'Japanese'), ('ka', 'Georgian'), ('kab', 'Kabyle'), ('kk', 'Kazakh'), ('km', 'Khmer'), ('kn', 'Kannada'), ('ko', 'Korean'), ('lb', 'Luxembourgish'), ('lt', 'Lithuanian'), ('lv', 'Latvian'), ('mk', 'Macedonian'), ('ml', 'Malayalam'), ('mn', 'Mongolian'), ('mr', 'Marathi'), ('my', 'Burmese'), ('nb', 'Norwegian Bokmål'), ('ne', 'Nepali'), ('nl', 'Dutch'), ('nn', 'Norwegian Nynorsk'), ('os', 'Ossetic'), ('pa', 'Punjabi'), ('pl', 'Polish'), ('pt', 'Portuguese'), ('pt-br', 'Brazilian Portuguese'), ('ro', 'Romanian'), ('ru', 'Russian'), ('sk', 'Slovak'), ('sl', 'Slovenian'), ('sq', 'Albanian'), ('sr', 'Serbian'), ('sr-latn', 'Serbian Latin'), ('sv', 'Swedish'), ('sw', 'Swahili'), ('ta', 'Tamil'), ('te', 'Telugu'), ('th', 'Thai'), ('tr', 'Turkish'), ('tt', 'Tatar'), ('udm', 'Udmurt'), ('uk', 'Ukrainian'), ('ur', 'Urdu'), ('vi', 'Vietnamese'), ('zh-hans', 'Simplified Chinese'), ('zh-hant', 'Traditional Chinese')]
LANGUAGES_BIDI ['he', 'ar', 'fa', 'ur']
LANGUAGE_CODE 'en-us'
LANGUAGE_COOKIE_AGE None
LANGUAGE_COOKIE_DOMAIN None
LANGUAGE_COOKIE_NAME 'django_language'
LANGUAGE_COOKIE_PATH '/'
LOCALE_PATHS []
LOGGING {'disable_existing_loggers': False, 'formatters': {'verbose': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s] %(message)s'}, 'verbose_low': {'datefmt': '%d/%b/%Y %H:%M:%S', 'format': '[%(asctime)s] %(levelname)s ' '[%(name)s:%(lineno)s]'}}, 'handlers': {'build': {'class': 'logging.FileHandler', 'filename': 'logs/build.log', 'formatter': 'verbose', 'level': 'DEBUG'}, 'django': {'class': 'logging.FileHandler', 'filename': 'logs/django.log', 'formatter': 'verbose', 'level': 'WARNING'}, 'protwis': {'class': 'logging.FileHandler', 'filename': 'logs/protwis.log', 'formatter': 'verbose', 'level': 'DEBUG'}}, 'loggers': {'build': {'handlers': ['build'], 'level': 'DEBUG'}, 'django': {'handlers': ['django'], 'level': 'WARNING', 'propagate': True}, 'protwis': {'handlers': ['protwis'], 'level': 'DEBUG'}}, 'version': 1}
LOGGING_CONFIG 'logging.config.dictConfig'
LOGIN_REDIRECT_URL '/accounts/profile/'
LOGIN_URL '/accounts/login/'
LOGOUT_REDIRECT_URL None
MANAGERS []
MEDIA_ROOT '/protwis/media/protwis'
MEDIA_URL '/media/'
MESSAGE_STORAGE 'django.contrib.messages.storage.fallback.FallbackStorage'
MIDDLEWARE ('common.middleware.stats.StatsMiddleware', 'debug_toolbar.middleware.DebugToolbarMiddleware', 'django.contrib.sessions.middleware.SessionMiddleware', 'django.middleware.common.CommonMiddleware', 'django.middleware.csrf.CsrfViewMiddleware', 'django.contrib.auth.middleware.AuthenticationMiddleware', 'django.contrib.messages.middleware.MessageMiddleware', 'django.middleware.clickjacking.XFrameOptionsMiddleware')
MIGRATION_MODULES {}
MONTH_DAY_FORMAT 'F j'
NUMBER_GROUPING 0
PASSWORD_HASHERS '********************'
PASSWORD_RESET_TIMEOUT_DAYS '********************'
PREPEND_WWW False
REFERENCE_POSITIONS {'D1S1': 'D1S1x50', 'D1S2': 'D1S2x50', 'D1T1': 'D1T1x50', 'D1e1': 'D1e1x50', 'ECL1': '23x50', 'ECL2': '45x50', 'H8': '8x50', 'ICL1': '12x50', 'ICL2': '34x50', 'TM1': '1x50', 'TM2': '2x50', 'TM3': '3x50', 'TM4': '4x50', 'TM5': '5x50', 'TM6': '6x50', 'TM7': '7x50'}
ROOT_URLCONF 'protwis.urls'
SECRET_KEY '********************'
SECURE_BROWSER_XSS_FILTER False
SECURE_CONTENT_TYPE_NOSNIFF False
SECURE_HSTS_INCLUDE_SUBDOMAINS False
SECURE_HSTS_PRELOAD False
SECURE_HSTS_SECONDS 0
SECURE_PROXY_SSL_HEADER None
SECURE_REDIRECT_EXEMPT []
SECURE_SSL_HOST None
SECURE_SSL_REDIRECT False
SERVER_EMAIL 'root@localhost'
SESSION_CACHE_ALIAS 'default'
SESSION_COOKIE_AGE 86400
SESSION_COOKIE_DOMAIN None
SESSION_COOKIE_HTTPONLY True
SESSION_COOKIE_NAME 'sessionid'
SESSION_COOKIE_PATH '/'
SESSION_COOKIE_SAMESITE 'Lax'
SESSION_COOKIE_SECURE False
SESSION_ENGINE 'django.contrib.sessions.backends.db'
SESSION_EXPIRE_AT_BROWSER_CLOSE False
SESSION_FILE_PATH None
SESSION_SAVE_EVERY_REQUEST False
SESSION_SERIALIZER 'django.contrib.sessions.serializers.PickleSerializer'
SETTINGS_MODULE 'protwis.settings'
SHORT_DATETIME_FORMAT 'm/d/Y P'
SHORT_DATE_FORMAT 'm/d/Y'
SIGNING_BACKEND 'django.core.signing.TimestampSigner'
SILENCED_SYSTEM_CHECKS []
SITE_NAME 'gpcr'
SITE_TITLE 'GPCRdb'
STATICFILES_DIRS ('/home/protwis/gpcrdb_test/static',)
STATICFILES_FINDERS ['django.contrib.staticfiles.finders.FileSystemFinder', 'django.contrib.staticfiles.finders.AppDirectoriesFinder']
STATICFILES_STORAGE 'django.contrib.staticfiles.storage.StaticFilesStorage'
STATIC_ROOT '/home/protwis/static_test/'
STATIC_URL '/static/'
SWAGGER_SETTINGS {'USE_SESSION_AUTH': False}
TEMPLATES [{'APP_DIRS': True, 'BACKEND': 'django.template.backends.django.DjangoTemplates', 'DIRS': [], 'OPTIONS': {'context_processors': ['django.contrib.auth.context_processors.auth', 'django.template.context_processors.debug', 'django.template.context_processors.i18n', 'django.template.context_processors.media', 'django.template.context_processors.static', 'django.template.context_processors.tz', 'django.contrib.messages.context_processors.messages', 'protwis.context_processors.current_site', 'protwis.context_processors.canonical_tag', 'protwis.context_processors.documentation_url', 'protwis.context_processors.google_analytics', 'protwis.context_processors.site_title'], 'debug': True}}]
TEST_NON_SERIALIZED_APPS []
TEST_RUNNER 'django.test.runner.DiscoverRunner'
THOUSAND_SEPARATOR ','
TIME_FORMAT 'P'
TIME_INPUT_FORMATS ['%H:%M:%S', '%H:%M:%S.%f', '%H:%M']
TIME_ZONE 'Europe/Copenhagen'
USE_I18N True
USE_L10N True
USE_THOUSAND_SEPARATOR False
USE_TZ True
USE_X_FORWARDED_HOST False
USE_X_FORWARDED_PORT False
WSGI_APPLICATION None
X_FRAME_OPTIONS 'SAMEORIGIN'
YEAR_MONTH_FORMAT 'F Y'

Headers

Request headers

Key Value
Accept text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8
Accept-Encoding br,gzip
Accept-Language en-US,en;q=0.5
Connection close
Host test.gpcrdb.org
If-Modified-Since Sat, 03 Dec 2022 13:43:21 GMT
User-Agent CCBot/2.0 (https://commoncrawl.org/faq/)
X-Forwarded-For 44.200.168.16
X-Forwarded-Proto https
X-Real-Ip 44.200.168.16

Response headers

Key Value
Cache-Control max-age=86400
Content-Length 954300
Content-Type text/html; charset=utf-8
Expires Sun, 26 Mar 2023 02:29:10 GMT
Vary Cookie
X-Frame-Options SAMEORIGIN

WSGI environ

Since the WSGI environ inherits the environment of the server, only a significant subset is shown below.

Key Value
PATH_INFO /structure/g_protein_structure_browser
QUERY_STRING
REMOTE_ADDR
REQUEST_METHOD GET
SCRIPT_NAME
SERVER_NAME test.gpcrdb.org
SERVER_PORT 443
SERVER_PROTOCOL HTTP/1.0
SERVER_SOFTWARE gunicorn/19.9.0

Request

View information

View function Arguments Keyword arguments URL name
structure.views.GProteinStructureBrowser () {} g_protein_structure_browser

No cookies

No session data

No GET data

No POST data

SQL queries from 1 connection

  •   default 1261.02 ms (428 queries including 401 similar and 396 duplicates )
  Query Timeline Time (ms) Action
  +
SELECT ••• "structure"."id", "structure"."protein_conformation_id", "structure"."structure_type_id", "structure"."pdb_code_id", "structure"."state_id", "structure"."author_state_id", "structure"."publication_id", "structure"."preferred_chain", "structure"."resolution", "structure"."publication_date", "structure"."pdb_data_id", "structure"."representative", "structure"."distance_representative", "structure"."contact_representative", "structure"."contact_representative_score", "structure"."inactive_class_contacts_fraction", "structure"."active_class_contacts_fraction", "structure"."class_contact_representative", "structure"."annotated", "structure"."refined", "structure"."distance", "structure"."tm6_angle", "structure"."gprot_bound_likeness", "structure"."sodium", "structure"."signprot_complex_id", "structure"."stats_text_id", "structure"."mammal", "structure"."closest_to_human", "protein_conformation"."id", "protein_conformation"."protein_id", "protein_conformation"."state_id", "protein"."id", "protein"."parent_id", "protein"."family_id", "protein"."species_id", "protein"."source_id", "protein"."residue_numbering_scheme_id", "protein"."sequence_type_id", "protein"."entry_name", "protein"."accession", "protein"."name", "protein"."sequence", "protein_family"."id", "protein_family"."parent_id", "protein_family"."slug", "protein_family"."name", T5."id", T5."parent_id", T5."slug", T5."name", T6."id", T6."parent_id", T6."slug", T6."name", T7."id", T7."parent_id", T7."slug", T7."name", "species"."id", "species"."latin_name", "species"."common_name", "protein_source"."id", "protein_source"."name", "web_link"."id", "web_link"."web_resource_id", "web_link"."index", "web_resource"."id", "web_resource"."slug", "web_resource"."name", "web_resource"."url", "protein_state"."id", "protein_state"."slug", "protein_state"."name", "publication"."id", "publication"."web_link_id", "publication"."journal_id", "publication"."title", "publication"."authors", "publication"."year", "publication"."reference", T14."id", T14."web_resource_id", T14."index", T15."id", T15."slug", T15."name", T15."url" FROM "structure" INNER JOIN "protein_conformation" ON ("structure"."protein_conformation_id" = "protein_conformation"."id") INNER JOIN "protein" ON ("protein_conformation"."protein_id" = "protein"."id") INNER JOIN "protein_family" ON ("protein"."family_id" = "protein_family"."id") LEFT OUTER JOIN "protein_family" T5 ON ("protein_family"."parent_id" = T5."id") LEFT OUTER JOIN "protein_family" T6 ON (T5."parent_id" = T6."id") LEFT OUTER JOIN "protein_family" T7 ON (T6."parent_id" = T7."id") INNER JOIN "species" ON ("protein"."species_id" = "species"."id") INNER JOIN "protein_source" ON ("protein"."source_id" = "protein_source"."id") INNER JOIN "web_link" ON ("structure"."pdb_code_id" = "web_link"."id") INNER JOIN "web_resource" ON ("web_link"."web_resource_id" = "web_resource"."id") INNER JOIN "protein_state" ON ("structure"."state_id" = "protein_state"."id") LEFT OUTER JOIN "publication" ON ("structure"."publication_id" = "publication"."id") LEFT OUTER JOIN "web_link" T14 ON ("publication"."web_link_id" = T14."id") LEFT OUTER JOIN "web_resource" T15 ON (T14."web_resource_id" = T15."id") WHERE "structure"."id" IN (SELECT ••• U0."structure_id" FROM "signprot_complex" U0 INNER JOIN "protein" U1 ON (U0."protein_id" = U1."id") INNER JOIN "protein_family" U2 ON (U1."family_id" = U2."id") WHERE U2."slug"::text LIKE '100%')
8.140998844225276%
 102.66

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in view(71)
  return self.dispatch(request, *args, **kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in dispatch(97)
  return handler(request, *args, **kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in get(158)
  context = self.get_context_data(**kwargs)
/home/protwis/gpcrdb_test/structure/views.py in get_context_data(125)
  for i in context['structures']:
  +
SELECT ••• ("structure_stabilizing_agents"."structure_id") AS "_prefetch_related_val_structure_id", "structure_stabilizing_agent"."id", "structure_stabilizing_agent"."slug", "structure_stabilizing_agent"."name" FROM "structure_stabilizing_agent" INNER JOIN "structure_stabilizing_agents" ON ("structure_stabilizing_agent"."id" = "structure_stabilizing_agents"."structurestabilizingagent_id") WHERE "structure_stabilizing_agents"."structure_id" IN (270, 7, 9, 293, 129, 303, 14, 416, 15, 538, 209, 23, 24, 28, 269, 490, 29, 31, 33, 121, 171, 34, 182, 39, 225, 54, 476, 60, 257, 61, 569, 576, 107, 65, 75, 68, 74, 84, 88, 431, 92, 96, 378, 97, 98, 101, 104, 105, 418, 106, 109, 110, 527, 118, 123, 376, 124, 333, 126, 408, 130, 139, 141, 379, 313, 142, 256, 144, 531, 294, 147, 263, 571, 149, 368, 151, 156, 158, 165, 603, 374, 579, 169, 175, 199, 217, 218, 404, 237, 541, 250, 277, 274, 506, 396, 517, 267, 289, 295, 341, 350, 554, 352, 587, 353, 371, 453, 381, 382, 390, 394, 422, 436, 445, 450, 452, 539, 503, 520, 525, 533, 589, 537, 563, 546, 558, 578, 584, 590, 299, 330, 568, 179, 128, 280, 489, 484, 252, 42, 397, 595, 2)
1.299088520470334%
 16.38

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in view(71)
  return self.dispatch(request, *args, **kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in dispatch(97)
  return handler(request, *args, **kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in get(158)
  context = self.get_context_data(**kwargs)
/home/protwis/gpcrdb_test/structure/views.py in get_context_data(125)
  for i in context['structures']:
  +
SELECT ••• "construct_construct"."id", "construct_construct"."name", "construct_construct"."protein_id", "construct_construct"."contributor_id", "construct_construct"."expression_id", "construct_construct"."solubilization_id", "construct_construct"."purification_id", "construct_construct"."crystallization_id", "construct_construct"."crystal_id", "construct_construct"."structure_id", "construct_construct"."schematics", "construct_construct"."snakecache", "construct_construct"."json" FROM "construct_construct" WHERE "construct_construct"."structure_id" IN (270, 7, 9, 293, 129, 303, 14, 416, 15, 538, 209, 23, 24, 28, 269, 490, 29, 31, 33, 121, 171, 34, 182, 39, 225, 54, 476, 60, 257, 61, 569, 576, 107, 65, 75, 68, 74, 84, 88, 431, 92, 96, 378, 97, 98, 101, 104, 105, 418, 106, 109, 110, 527, 118, 123, 376, 124, 333, 126, 408, 130, 139, 141, 379, 313, 142, 256, 144, 531, 294, 147, 263, 571, 149, 368, 151, 156, 158, 165, 603, 374, 579, 169, 175, 199, 217, 218, 404, 237, 541, 250, 277, 274, 506, 396, 517, 267, 289, 295, 341, 350, 554, 352, 587, 353, 371, 453, 381, 382, 390, 394, 422, 436, 445, 450, 452, 539, 503, 520, 525, 533, 589, 537, 563, 546, 558, 578, 584, 590, 299, 330, 568, 179, 128, 280, 489, 484, 252, 42, 397, 595, 2)
61.1074526388551%
 770.58

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in view(71)
  return self.dispatch(request, *args, **kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in dispatch(97)
  return handler(request, *args, **kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in get(158)
  context = self.get_context_data(**kwargs)
/home/protwis/gpcrdb_test/structure/views.py in get_context_data(125)
  for i in context['structures']:
  +
SELECT ••• "construct_crystallization"."id", "construct_crystallization"."crystal_type_id", "construct_crystallization"."crystal_method_id", "construct_crystallization"."remarks", "construct_crystallization"."protein_conc", "construct_crystallization"."protein_conc_unit", "construct_crystallization"."temp", "construct_crystallization"."ph_start", "construct_crystallization"."ph_end" FROM "construct_crystallization" WHERE "construct_crystallization"."id" IN (68, 11, 236, NULL, 117, 246, 247, 248, 249, 250, 251, 92)
0.33068051554396943%
 4.17

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in view(71)
  return self.dispatch(request, *args, **kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in dispatch(97)
  return handler(request, *args, **kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in get(158)
  context = self.get_context_data(**kwargs)
/home/protwis/gpcrdb_test/structure/views.py in get_context_data(125)
  for i in context['structures']:
  +
SELECT ••• "construct_crystallization_methods"."id", "construct_crystallization_methods"."name" FROM "construct_crystallization_methods" WHERE "construct_crystallization_methods"."id" IN (2, 3, 4)
0.04426089690614251%
 0.56

Connection: default

/usr/lib/python3.6/concurrent/futures/thread.py in _worker(69)
  work_item.run()
/usr/lib/python3.6/concurrent/futures/thread.py in run(56)
  result = self.fn(*self.args, **self.kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle(279)
  keepalive = self.handle_request(req, conn)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/gunicorn/workers/gthread.py in handle_request(328)
  respiter = self.wsgi(environ, resp.start_response)
/home/protwis/gpcrdb_test/common/middleware/stats.py in __call__(34)
  response = self.get_response(request)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in view(71)
  return self.dispatch(request, *args, **kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in dispatch(97)
  return handler(request, *args, **kwargs)
/home/protwis/gpcrdb_env/lib/python3.6/site-packages/django/views/generic/base.py in get(158)
  context = self.get_context_data(**kwargs)
/home/protwis/gpcrdb_test/structure/views.py in get_context_data(125)
  for i in context['structures']: