CT receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7TYY

RESOLUTION

3.0 Å

REFERENCE

10.1126/SCIENCE.ABM9609

PUBLICATION DATE

March 23, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

137 interactions (Click to see)

LIGANDS

calcitonin (salmon synthetic) - Agonist pubchem chembl_ligand pubchem drugbank

PHYSIOLOGICAL LIGANDS

adrenomedullin, calcitonin, adrenomedullin 2/intermedin, α-CGRP, amylin, β-CGRP



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 N 395 8x47 G.H5 Q 390 G.H5.22
Hydrophobic TM5 K 326 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 V 252 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 252 - G.H5 I 383 G.H5.15
Polar ICL2 V 252 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 252 - G.H5 H 387 G.H5.19
Hydrophobic TM5 M 327 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 M 327 5x65 G.H5 L 394 G.H5.26
Aromatic TM2 H 184 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM2 H 184 2x50 G.H5 Y 391 G.H5.23
Van-der-waals TM2 H 184 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 326 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 244 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 348 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM3 Y 243 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 243 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 252 - G.H5 Q 384 G.H5.16
Hydrophobic H8 N 395 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 395 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 K 256 - G.HN K 34 G.HN.51
Hydrophobic TM3 L 244 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 244 3x54 G.H5 Y 391 G.H5.23
Polar H8 N 396 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 N 396 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 253 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 253 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 K 256 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 256 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL3 T 330 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 E 329 5x67 G.H5 D 381 G.H5.13
Hydrophobic TM7 Y 391 7x57 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 253 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 253 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 253 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 K 256 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 K 256 - G.HN Q 35 G.HN.52
Hydrophobic TM5 V 322 5x60 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 322 5x60 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 248 3x58 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 253 - G.S3 F 219 G.S3.03
Van-der-waals ICL2 F 253 - G.S3 F 219 G.S3.03
Hydrophobic TM6 A 344 6x41 G.H5 L 393 G.H5.25
Polar TM2 R 180 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 180 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 180 2x46 G.H5 Q 390 G.H5.22
Polar TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 248 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM6 I 347 6x44 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 347 6x44 G.H5 L 393 G.H5.25
Hydrophobic TM6 I 347 6x44 G.H5 E 392 G.H5.24
Aromatic ICL2 F 253 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 253 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 253 - G.H5 F 376 G.H5.08
Hydrophobic TM5 L 323 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 323 5x61 G.H5 L 393 G.H5.25
Ionic TM5 K 326 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 326 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 326 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 L 323 5x61 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 323 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM3 I 248 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 248 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL2 E 255 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 I 319 5x57 G.H5 L 393 G.H5.25
Ionic TM5 E 329 5x67 G.H5 R 385 G.H5.17
Polar TM5 E 329 5x67 G.H5 R 385 G.H5.17
Polar ICL3 T 330 - G.H5 R 385 G.H5.17
Aromatic TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 180 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 253 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 253 - G.H5 R 380 G.H5.12
Hydrophobic TM3 I 248 3x58 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 247 3x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 253 - G.H5 C 379 G.H5.11
Ionic ICL2 E 255 - G.H5 H 387 G.H5.19
Polar ICL2 E 255 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 E 255 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 E 255 - G.H5 H 387 G.H5.19
Hydrophobic TM3 L 247 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 247 3x57 G.H5 H 387 G.H5.19
Polar TM6 K 343 6x40 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 343 6x40 G.H5 E 392 G.H5.24
Polar TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 326 5x64 G.H5 Q 384 G.H5.16
Polar TM3 V 249 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 V 249 3x59 G.H5 R 380 G.H5.12
Hydrophobic ICL2 V 252 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 252 - G.H5 R 380 G.H5.12
Hydrophobic TM5 L 323 5x61 G.H5 L 388 G.H5.20
Polar TM5 K 326 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 326 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 326 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM6 L 351 6x48 G.H5 Y 391 G.H5.23