DRUGS RECEPTOR CLINICAL INFORMATION
NAME
INDICATION
TARGET
TARGET LEVEL
CLASS
FAMILY
STATUS
PHASE
CLINICAL STATUS
YEAR OF
APPROVAL
DRUG TYPE
MECHANISM OF
ACTION
NHS
REFERENCES
abaloparatide Anti-Osteoporotic pth1r_human primary B1 (Secretin) Parathyroid hormone receptors approved 4 - 2017 peptide agonist no Refs
abarelix Antineoplastic gnrhr_human primary A (Rhodopsin) Gonadotrophin-releasing hormone receptors approved 4 - 2003 peptide antagonist no Refs
acamprosate Antineoplastic grm5_human secondary C (Glutamate) Metabotropic glutamate receptors approved 4 - 2004 small molecule antagonist yes Refs
acebutolol Antihypertensive adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1984 small molecule antagonist yes Refs
acepromazine Antipsychotic drd1_human primary A (Rhodopsin) Dopamine receptors approved 4 - - small molecule antagonist no Refs
acepromazine Antipsychotic 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - - small molecule antagonist no Refs
acepromazine Antipsychotic drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - - small molecule antagonist no Refs
acepromazine Antipsychotic 5ht1a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - - small molecule antagonist no Refs
acepromazine Hypnotics And Sedatives hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - - small molecule antagonist no Refs
acetophenazine Schizophrenia drd1_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1961 small molecule antagonist no Refs
acetophenazine Schizophrenia drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1961 small molecule antagonist no Refs
acetylcholine Antiglaucomic acm3_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1973 small molecule agonist yes Refs
acipimox Lipid-Lowering hcar2_human primary A (Rhodopsin) Hydroxycarboxylic acid receptors approved 4 - 2003 small molecule agonist yes Refs
agomelatine Anti-Depressant 5ht2c_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2009 small molecule antagonist yes Refs
agomelatine Anti-Depressant mtr1a_human primary A (Rhodopsin) Melatonin approved 4 - 2009 small molecule agonist yes Refs
agomelatine Anti-Depressant mtr1b_human primary A (Rhodopsin) Melatonin approved 4 - 2009 small molecule agonist yes Refs
aclidinium Bronchodilator acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 2012 small molecule antagonist yes Refs
aclidinium Bronchodilator acm2_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 2012 small molecule antagonist yes Refs
aclidinium Bronchodilator acm3_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 2012 small molecule antagonist yes Refs
aclidinium Bronchodilator acm4_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 2012 small molecule antagonist yes Refs
aclidinium Bronchodilator acm5_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 2012 small molecule antagonist yes Refs
acrivastine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1994 small molecule antagonist yes Refs
adenosine Analgesics aa3r_human primary A (Rhodopsin) Adenosine receptors approved 4 - 1989 small molecule agonist yes Refs
adenosine Analgesics aa2ar_human primary A (Rhodopsin) Adenosine receptors approved 4 - 1989 small molecule agonist yes Refs
adenosine Analgesics aa2br_human primary A (Rhodopsin) Adenosine receptors approved 4 - 1989 small molecule agonist yes Refs
adenosine Analgesics aa1r_human primary A (Rhodopsin) Adenosine receptors approved 4 - 1989 small molecule agonist yes Refs
albiglutide Antidiabetic glp1r_human primary B1 (Secretin) Glucagon receptor family approved 4 - 2014 protein agonist yes Refs
albuterol Chronic Obstructive Pulmonary Disease (Copd) adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1981 small molecule agonist no Refs
alcaftadine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 2010 small molecule antagonist no Refs
alprenolol Anti-Arrhythmia ; Antihypertensive adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1966 small molecule antagonist no Refs
alfentanil Analgesics oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 1986 small molecule agonist yes Refs
alfuzosin Benign Prostatic Hyperplasia ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2003 small molecule agonist yes Refs
alfuzosin Benign Prostatic Hyperplasia ada1d_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2003 small molecule agonist yes Refs
alfuzosin Benign Prostatic Hyperplasia ada1b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2003 small molecule agonist yes Refs
almotriptan Anti-Migraine 5ht1b_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2001 small molecule agonist yes Refs
almotriptan Anti-Migraine 5ht1d_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2001 small molecule agonist yes Refs
alprenolol Anti-Arrhythmia ; Antihypertensive adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1966 small molecule antagonist no Refs
alprostadil Sexual Dysfunction pe2r2_human primary A (Rhodopsin) Prostanoid receptors approved 4 - 1981 small molecule agonist yes Refs
alprostadil Sexual Dysfunction pe2r1_human primary A (Rhodopsin) Prostanoid receptors approved 4 - 1981 small molecule agonist yes Refs
alverine Antispasmodics 5ht1a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2014 small molecule antagonist yes Refs
alvimopan Opioid-Induced Bowel Dysfunction oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 2008 small molecule antagonist no Refs
alvimopan Opiate Antagonists oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 2008 small molecule antagonist no Refs
amantadine hcl Dyskinesias drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1968 small molecule antagonist no Refs
ambrisentan Antihypertensive ednra_human primary A (Rhodopsin) Endothelin receptors approved 4 - 2007 small molecule antagonist yes Refs
amiodarone Anti-Arrhythmia adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1985 small molecule antagonist yes Refs
amitriptyline Analgesics 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1961 small molecule antagonist yes Refs
amoxapine Unipolar Depression drd1_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1980 small molecule antagonist yes Refs
amoxapine Unipolar Depression drd3_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1980 small molecule antagonist yes Refs
amoxapine Unipolar Depression drd4_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1980 small molecule antagonist yes Refs
amoxapine Unipolar Depression drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1980 small molecule antagonist yes Refs
amphetamine Cognitive Dysfunction; Adhd taar1_human secondary A (Rhodopsin) Trace amine receptors approved 4 - 1996 small molecule agonist no Refs
anileridine Analgesics; Narcotics oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 1982 small molecule agonist no Refs
anisotropine methylbromide Antispasmodics; Anti-Ulcer acm2_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1982 small molecule antagonist no Refs
anisotropine methylbromide Antispasmodics; Anti-Ulcer acm3_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1982 small molecule antagonist no Refs
anisotropine methylbromide Antispasmodics; Anti-Ulcer acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1982 small molecule antagonist no Refs
antazoline Atrial Fibrillation hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1994 small molecule antagonist yes Refs
apomorphine Anti-Parkisonian drd3_human primary A (Rhodopsin) Dopamine receptors approved 4 - 2004 small molecule agonist yes Refs
apomorphine Anti-Parkisonian drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 2004 small molecule agonist yes Refs
apomorphine Anti-Parkisonian drd4_human primary A (Rhodopsin) Dopamine receptors approved 4 - 2004 small molecule agonist yes Refs
atropine Nerve Antidote acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1973 small molecule antagonist yes Refs
atropine Nerve Antidote acm3_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1973 small molecule antagonist yes Refs
atropine Nerve Antidote acm4_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1973 small molecule antagonist yes Refs
apraclonidine Antiglaucomic ada2b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1987 small molecule agonist yes Refs
apraclonidine Antiglaucomic ada2c_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1987 small molecule agonist yes Refs
apraclonidine Antiglaucomic ada2a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1987 small molecule agonist yes Refs
aprepitant Antiemetics nk1r_human primary A (Rhodopsin) Tachykinin receptors approved 4 - 2003 small molecule antagonist yes Refs
arbutamine Cardiotonic adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1997 small molecule agonist no Refs
arformoterol Bronchodilator adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2006 small molecule agonist no Refs
aripiprazole Schizophrenia 5ht1a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2002 small molecule partial agonist yes Refs
aripiprazole Psychosis 5ht1a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2015 small molecule partial agonist yes Refs
aripiprazole Schizophrenia 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2002 small molecule partial agonist yes Refs
aripiprazole Psychosis 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2015 small molecule partial agonist yes Refs
aripiprazole Schizophrenia drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 2002 small molecule partial agonist yes Refs
aripiprazole Psychosis drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 2015 small molecule partial agonist yes Refs
asenapine Schizophrenia 5ht1a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2009 small molecule antagonist yes Refs
asenapine Schizophrenia 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2009 small molecule antagonist yes Refs
asenapine Schizophrenia 5ht2c_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2009 small molecule antagonist yes Refs
asenapine Schizophrenia 5ht6r_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2009 small molecule antagonist yes Refs
atropine Nerve Antidote acm5_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1973 small molecule antagonist yes Refs
asenapine Schizophrenia 5ht1b_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2009 small molecule antagonist yes Refs
asenapine Schizophrenia 5ht5a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2009 small molecule antagonist yes Refs
asenapine Schizophrenia 5ht7r_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2009 small molecule antagonist yes Refs
asenapine Schizophrenia drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 2009 small molecule antagonist yes Refs
asfotase alfa Hypophosphatasia s1pr1_human primary A (Rhodopsin) Lysophospholipid (S1P) receptors approved 4 - 2015 enzyme agonist no Refs
astemizole Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1988 small molecule antagonist no Refs
atenolol Anti-Arrhythmia ; Antihypertensive adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1981 small molecule antagonist yes Refs
atosiban Labor Repressant oxyr_human primary A (Rhodopsin) Vasopressin and oxytocin receptors approved 4 - 2013 small molecule antagonist no Refs
atropine Nerve Antidote acm2_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1973 small molecule antagonist yes Refs
azatadine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1977 small molecule antagonist yes Refs
baclofen Anti-Spastic gabr2_human primary C (Glutamate) GABAB receptors approved 4 - 1977 small molecule agonist yes Refs
azelastine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1996 small molecule antagonist yes Refs
azelastine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 2012 small molecule antagonist yes Refs
azilsartan medoxomil Antihypertensive agtr1_human primary A (Rhodopsin) Angiotensin receptors approved 4 - 2011 small molecule antagonist yes Refs
baclofen Anti-Spastic gabr1_human primary C (Glutamate) GABAB receptors approved 4 - 1977 small molecule agonist yes Refs
benperidol Antipsychotic drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 2006 small molecule antagonist yes Refs
benzphetamine Central Nervous System Stimulants ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1960 small molecule agonist no Refs
benzphetamine Central Nervous System Stimulants ada2a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1960 small molecule agonist no Refs
benztropine Antiparkinson acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1954 small molecule antagonist no Refs
bepotastine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 2009 small molecule antagonist no Refs
betahistine Vertigo hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1970 small molecule agonist yes Refs
betahistine Vertigo hrh3_human primary A (Rhodopsin) Histamine receptors approved 4 - 1970 small molecule antagonist yes Refs
betanechol Antidiabetic acm2_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1970 small molecule agonist no Refs
betaxolol Antihypertensive adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1985 small molecule antagonist yes Refs
betazole Diagnostic hrh2_human primary A (Rhodopsin) Histamine receptors approved 4 - 1982 small molecule agonist no Refs
bethanechol Eosinophilic Esophagitis acm2_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1948 small molecule agonist yes Refs
bromocriptine Antidiabetic drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1978 small molecule agonist yes Refs
bethanidine Antihypertensive ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1982 small molecule agonist no Refs
bethanidine Antihypertensive ada1b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1982 small molecule agonist no Refs
bethanidine Antihypertensive ada1d_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1982 small molecule agonist no Refs
bromocriptine Antidiabetic drd3_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1978 small molecule agonist yes Refs
bethanidine Antihypertensive ada2a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1982 small molecule agonist no Refs
bethanidine Antihypertensive ada2b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1982 small molecule agonist no Refs
bethanidine Antihypertensive ada2c_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1982 small molecule agonist no Refs
bilastine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 2010 small molecule antagonist yes Refs
bimatoprost Antiglaucomic pf2r_human primary A (Rhodopsin) Prostanoid receptors approved 4 - 2001 small molecule agonist yes Refs
bimatoprost Antiglaucomic pe2r1_human primary A (Rhodopsin) Prostanoid receptors approved 4 - 2001 small molecule agonist yes Refs
bimatoprost Antiglaucomic pe2r3_human primary A (Rhodopsin) Prostanoid receptors approved 4 - 2001 small molecule agonist yes Refs
biperiden Antidyskinetics acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1959 small molecule antagonist yes Refs
bisoprolol Antihypertensive adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1992 small molecule antagonist yes Refs
bitolterol Obstructive Lung Disease adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1984 small molecule agonist no Refs
bopindolol Antihypertensive adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - - small molecule partial agonist no Refs
bosentan Antihypertensive ednra_human primary A (Rhodopsin) Endothelin receptors approved 4 - 2001 small molecule antagonist yes Refs
bosentan Antihypertensive ednrb_human primary A (Rhodopsin) Endothelin receptors approved 4 - 2001 small molecule antagonist yes Refs
bromodiphenhydramine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1954 small molecule antagonist no Refs
brexpiprazole Anti-Depressant 5ht1a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2015 small molecule partial agonist no Refs
brexpiprazole Anti-Depressant 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2015 small molecule partial agonist no Refs
brexpiprazole Anti-Depressant drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 2015 small molecule partial agonist no Refs
bromopride Antiemetics drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - - small molecule antagonist no Refs
brimonidine Antiglaucomic ada2a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1996 small molecule agonist yes Refs
brimonidine Antiglaucomic ada2c_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1996 small molecule agonist yes Refs
brompheniramine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1957 small molecule antagonist yes Refs
brimonidine Antiglaucomic ada2b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1996 small molecule agonist yes Refs
buclizine Antiemetics acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1982 small molecule antagonist no Refs
buclizine Antiemetics hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1982 small molecule antagonist no Refs
bupranolol Antihypertensive adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - - small molecule antagonist no Refs
buprenorphine Anti-Depressant; Analgesics; Opioid Addiction oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 1981 small molecule agonist yes Refs
buprenorphine Anti-Depressant; Analgesics; Opioid Addiction oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 2016 small molecule agonist yes Refs
buspirone Anti-Anxiety drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1986 small molecule partial agonist yes Refs
buprenorphine Anti-Depressant; Analgesics; Opioid Addiction oprk_human primary A (Rhodopsin) Opioid receptors approved 4 - 2016 small molecule agonist yes Refs
butorphanol Analgesics oprk_human primary A (Rhodopsin) Opioid receptors approved 4 - 1978 small molecule partial agonist no Refs
butorphanol Analgesics oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 1978 small molecule partial agonist no Refs
buprenorphine Anti-Depressant; Analgesics; Opioid Addiction oprk_human primary A (Rhodopsin) Opioid receptors approved 4 - 1981 small molecule agonist yes Refs
buserelin Lhrh Analogue gnrhr_human primary A (Rhodopsin) Gonadotrophin-releasing hormone receptors approved 4 - - peptide not available yes Refs
buspirone Anti-Anxiety 5ht1a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1986 small molecule partial agonist yes Refs
butorphanol Analgesics oprd_human primary A (Rhodopsin) Opioid receptors approved 4 - 1978 small molecule partial agonist no Refs
butriptyline Anti-Depressant 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1974 small molecule antagonist no Refs
butriptyline Anti-Depressant hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1974 small molecule antagonist no Refs
cabergoline Antiparkinson drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1996 small molecule agonist yes Refs
caffeine Central Nervous System Stimulants aa1r_human primary A (Rhodopsin) Adenosine receptors approved 4 - 1999 small molecule antagonist yes Refs
caffeine Central Nervous System Stimulants aa2ar_human primary A (Rhodopsin) Adenosine receptors approved 4 - 1999 small molecule antagonist yes Refs
calcitonin human Parathyroid Disease calcr_human primary B1 (Secretin) Calcitonin receptors approved 4 - 1986 peptide agonist no Refs
calcitonin salmon recombinant Paget'S Disease calcr_human primary B1 (Secretin) Calcitonin receptors approved 4 - 2005 peptide agonist no Refs
calcitonin salmon recombinant Osteitis Deformans calcr_human primary B1 (Secretin) Calcitonin receptors approved 4 - 2005 peptide agonist no Refs
calcitonin salmon recombinant Postmenopausal Osteoporosis calcr_human primary B1 (Secretin) Calcitonin receptors approved 4 - 1978 peptide agonist no Refs
candesartan cilexetil Antihypertensive agtr1_human primary A (Rhodopsin) Angiotensin receptors approved 4 - 1998 small molecule antagonist yes Refs
cangrelor Antithrombotic p2y12_human primary A (Rhodopsin) P2Y receptors approved 4 - 2015 small molecule antagonist no Refs
captodiame Anxiolytic drd3_human primary A (Rhodopsin) Dopamine receptors approved 4 - - small molecule agonist no Refs
captodiame Anxiolytic 5ht2c_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - - small molecule antagonist no Refs
carbachol Antiglaucomic acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1972 small molecule agonist no Refs
carbachol Antiglaucomic acm2_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1972 small molecule agonist no Refs
carbinoxamine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 2003 small molecule antagonist no Refs
carboprost tromethamine Abortifacient pe2r1_human primary A (Rhodopsin) Prostanoid receptors approved 4 - 1965 small molecule agonist no Refs
cariprazine Schizophrenia drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 2015 small molecule partial agonist no Refs
cariprazine Schizophrenia drd3_human primary A (Rhodopsin) Dopamine receptors approved 4 - 2015 small molecule partial agonist no Refs
chlophedianol Antitussive hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1987 small molecule antagonist no Refs
carphenazine Schizophrenia drd1_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1982 small molecule antagonist no Refs
carphenazine Schizophrenia drd5_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1982 small molecule antagonist no Refs
carphenazine Schizophrenia drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1982 small molecule antagonist no Refs
carteolol Antiglaucomic adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1988 small molecule antagonist yes Refs
carteolol Cardiovascular Disease adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1988 small molecule antagonist yes Refs
carvedilol Cardiovascular Disease adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1995 small molecule antagonist yes Refs
carvedilol Congestive Heart Failure ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1995 small molecule antagonist yes Refs
celiprolol Antihypertensive adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - - small molecule agonist yes Refs
celiprolol Antihypertensive adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - - small molecule antagonist yes Refs
ceruletide Diagnostic cckar_human primary A (Rhodopsin) Cholecystokinin receptors withdrawn 4 - 1982 small molecule agonist no Refs
cetirizine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 2007 small molecule antagonist yes Refs
cetrorelix Antineoplastic gnrhr_human primary A (Rhodopsin) Gonadotrophin-releasing hormone receptors approved 4 - 2000 peptide antagonist yes Refs
cevimeline Parasympathomimetics acm3_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 2000 small molecule agonist no Refs
cevimeline Parasympathomimetics acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 2000 small molecule agonist no Refs
chlorcyclizine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - - small molecule antagonist no Refs
chloropyramine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - - small molecule antagonist no Refs
chlorpheniramine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1950 small molecule antagonist no Refs
chlorpromazine Psychosis 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1957 small molecule antagonist yes Refs
chlorpromazine Psychosis drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1957 small molecule antagonist yes Refs
chlorprothixene Schizophrenia 5ht2b_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1967 small molecule antagonist yes Refs
chlorprothixene Schizophrenia 5ht2c_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1967 small molecule antagonist yes Refs
chorionic gonadotropin Antineoplastic lshr_human primary A (Rhodopsin) Glycoprotein hormone receptors approved 4 - 1973 protein agonist no Refs
chlorprothixene Schizophrenia drd1_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1967 small molecule antagonist yes Refs
chlorprothixene Schizophrenia drd3_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1967 small molecule antagonist yes Refs
chlorprothixene Schizophrenia 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1967 small molecule antagonist yes Refs
chlorprothixene Schizophrenia drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1967 small molecule antagonist yes Refs
chorionic gonadotropin Stroke lshr_human primary A (Rhodopsin) Glycoprotein hormone receptors approved 4 - 1973 protein agonist no Refs
chorionic gonadotropin Fertility lshr_human primary A (Rhodopsin) Glycoprotein hormone receptors approved 4 - 1973 protein agonist no Refs
cimetidine Antihistamines hrh2_human primary A (Rhodopsin) Histamine receptors approved 4 - 1977 small molecule antagonist yes Refs
cimetidine Gi Anti-Ulcer ; Antihistamines hrh2_human primary A (Rhodopsin) Histamine receptors approved 4 - 1977 small molecule antagonist yes Refs
cinacalcet Hyperparathyroidism casr_human primary C (Glutamate) Calcium-sensing receptors approved 4 - 2004 small molecule PAM yes Refs
cinacalcet Calcimimetics casr_human primary C (Glutamate) Calcium-sensing receptors approved 4 - 2004 small molecule PAM yes Refs
cinitapride Gastrointestinal Disorders 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - - small molecule antagonist no Refs
cinitapride Gastrointestinal Disorders 5ht1a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - - small molecule agonist no Refs
cinnarizine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1989 small molecule antagonist yes Refs
cisapride Parasympathomimetics 5ht4r_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1993 small molecule agonist no Refs
clemastine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1977 small molecule antagonist yes Refs
clenbuterol Bronchodilator adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - - small molecule agonist no Refs
kp201 Analgesics oprd_human primary A (Rhodopsin) Opioid receptors in trial 2 completed - small molecule agonist no
kp201 Analgesics oprk_human primary A (Rhodopsin) Opioid receptors in trial 2 completed - small molecule agonist no
kp201 Analgesics oprm_human primary A (Rhodopsin) Opioid receptors in trial 2 completed - small molecule agonist no
clidinium Gi Anti-Ulcer ; Anticholinergic; Antispasmodics acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 2013 small molecule antagonist no Refs
clofedanol Antitussive hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1987 small molecule antagonist no Refs
cyclobenzaprine Anti-Depressant 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1977 small molecule antagonist no Refs
clonidine Diabetic Neuropathy; Adhd; Antimucositic ada2b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1974 small molecule agonist yes Refs
clonidine Diabetic Neuropathy; Adhd; Antimucositic ada2c_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1974 small molecule agonist yes Refs
clonidine Diabetic Neuropathy; Adhd; Antimucositic ada2a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1974 small molecule agonist yes Refs
clopidogrel Antiplatelet p2y12_human primary A (Rhodopsin) P2Y receptors approved 4 - 1997 small molecule antagonist yes Refs
clopidogrel Antithrombotic p2y12_human primary A (Rhodopsin) P2Y receptors approved 4 - 1997 small molecule antagonist yes Refs
elsiglutide Antidiuretic glp2r_human primary B1 (Secretin) Glucagon receptor family in trial 2 completed - peptide agonist no
clozapine Schizophrenia drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1989 small molecule antagonist yes Refs
clozapine Schizophrenia 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1989 small molecule antagonist yes Refs
cocaine Local Anesthetic drd3_human secondary A (Rhodopsin) Dopamine receptors approved 4 - 1982 small molecule agonist yes Refs
cocaine Local Anesthetic oprk_human secondary A (Rhodopsin) Opioid receptors approved 4 - 1982 small molecule agonist yes Refs
codeine Analgesics oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 2009 small molecule agonist yes Refs
codeine Analgesics oprd_human primary A (Rhodopsin) Opioid receptors approved 4 - 2009 small molecule agonist yes Refs
codeine Analgesics oprk_human primary A (Rhodopsin) Opioid receptors approved 4 - 2009 small molecule agonist yes Refs
conivaptan Hyponatremia v2r_human primary A (Rhodopsin) Vasopressin and oxytocin receptors approved 4 - 2005 small molecule antagonist no Refs
conivaptan Hyponatremia v1ar_human primary A (Rhodopsin) Vasopressin and oxytocin receptors approved 4 - 2005 small molecule antagonist no Refs
corticorelin ovine triflutate Diagnostic crfr1_human primary B1 (Secretin) Corticotropin-releasing factor receptors approved 4 - 1996 small molecule agonist no Refs
cosyntropin Diagnostic acthr_human primary A (Rhodopsin) Melanocortin receptors approved 4 - 1970 peptide agonist no Refs
cromolyn sodium Anti-Allergenic gpr35_human primary A (Rhodopsin) Class A orphans approved 4 - 2000 small molecule agonist no Refs
cyclizine Antiemetics hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1982 small molecule antagonist yes Refs
cyclobenzaprine Muscle Relaxants 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1977 small molecule antagonist no Refs
cyclopentolate Mydriatics acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1974 small molecule antagonist yes Refs
cycrimine Antiparkinson acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1982 small molecule antagonist no Refs
cyproheptadine Anti-Allergic ; Appetite Stimulant hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1961 small molecule antagonist yes Refs
cyproheptadine Anti-Allergic ; Appetite Stimulant 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1961 small molecule antagonist yes Refs
danazol Diabetic Macular Edema gnrhr_human primary A (Rhodopsin) Gonadotrophin-releasing hormone receptors approved 4 - 1976 small molecule agonist yes Refs
danazol Antiendometriosis ; Antineoplastic gnrhr_human primary A (Rhodopsin) Gonadotrophin-releasing hormone receptors approved 4 - 1976 small molecule agonist yes Refs
dapiprazole Opthalmological ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1990 small molecule antagonist no Refs
dapiprazole Opthalmological ada1b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1990 small molecule antagonist no Refs
dapiprazole Opthalmological ada1d_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1990 small molecule antagonist no Refs
darifenacin Overactive Bladder acm3_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 2004 small molecule antagonist yes Refs
degarelix Antineoplastic gnrhr_human primary A (Rhodopsin) Gonadotrophin-releasing hormone receptors approved 4 - 2008 small molecule antagonist yes Refs
desipramine Anti-Depressant hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1964 small molecule antagonist no Refs
desloratadine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 2001 small molecule antagonist yes Refs
desmopressin Antidiuretic v1ar_human primary A (Rhodopsin) Vasopressin and oxytocin receptors approved 4 - 1978 peptide not available yes Refs
desmopressin Antidiuretic v1br_human primary A (Rhodopsin) Vasopressin and oxytocin receptors approved 4 - 1978 peptide not available yes Refs
desmopressin Antidiuretic v2r_human primary A (Rhodopsin) Vasopressin and oxytocin receptors approved 4 - 1978 peptide agonist yes Refs
dexbrompheniramine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1963 small molecule antagonist no Refs
dexchlorpheniramine Sunburn hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1981 small molecule antagonist no Refs
dexmedetomidine Analgesics ada2b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1999 small molecule agonist no Refs
dexmedetomidine Antineoplastic ada2c_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1999 small molecule agonist no Refs
dexmedetomidine Analgesics; Hypnotics And Sedatives ada2a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1999 small molecule agonist no Refs
dezocine Analgesics oprk_human primary A (Rhodopsin) Opioid receptors approved 4 - 1989 small molecule partial agonist no Refs
dezocine Analgesics oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 1989 small molecule partial agonist no Refs
dicyclomine Antispasmodics acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1950 small molecule antagonist no Refs
difenoxin Recurrent Infection Of The Gastrointestinal Tract oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 1978 small molecule agonist no Refs
dihydrocodeine Analgesics oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 1958 small molecule agonist yes Refs
dihydroergotamine Anti-Migraine 5ht1b_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1997 small molecule agonist no Refs
dipivefrin Antiglaucomic adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1980 small molecule agonist yes Refs
dihydroergotamine Anti-Migraine 5ht1d_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1997 small molecule agonist no Refs
dimenhydrinate Antiemetics hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1972 small molecule antagonist yes Refs
dimetindene Anti-Allergic acm2_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - - small molecule antagonist no Refs
dimetindene Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - - small molecule antagonist no Refs
dinoprost tromethamine Abortifacient pi2r_human primary A (Rhodopsin) Prostanoid receptors approved 4 - 1981 small molecule agonist no Refs
dinoprostone Abortifacient pe2r4_human primary A (Rhodopsin) Prostanoid receptors approved 4 - 1977 small molecule agonist yes Refs
dinoprostone Abortifacient pe2r1_human primary A (Rhodopsin) Prostanoid receptors approved 4 - 1977 small molecule agonist yes Refs
dinoprostone Abortifacient pe2r3_human primary A (Rhodopsin) Prostanoid receptors approved 4 - 1977 small molecule agonist yes Refs
dinoprostone Abortifacient pe2r2_human primary A (Rhodopsin) Prostanoid receptors approved 4 - 1977 small molecule agonist yes Refs
diphemanil Bronchodilator acm3_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1976 small molecule antagonist no Refs
diphenhydramine Anti-Allergic ; Hypnotics And Sedatives; Antiemetics; Antipruritics; Antitussives hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1946 small molecule antagonist yes Refs
diphenidol Antiemetics acm2_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1967 small molecule antagonist no Refs
diphenidol Antiemetics acm3_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1967 small molecule antagonist no Refs
diphenidol Antiemetics acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1967 small molecule antagonist no Refs
diphenoxylate Antidiuretic oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 1960 small molecule agonist no Refs
diphenylpyraline Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1982 small molecule antagonist no Refs
dipivefrin Opthalmological ada2a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1980 small molecule agonist yes Refs
dipivefrin Antiglaucomic ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1980 small molecule agonist yes Refs
dobutamine Cardiotonic adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1978 small molecule agonist no Refs
dopamine Hypotension adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1974 small molecule agonist no Refs
doxepin Hypnotics And Sedatives hrh2_human primary A (Rhodopsin) Histamine receptors approved 4 - 1969 small molecule antagonist yes Refs
doxacurium Muscle Relaxants acm2_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1991 small molecule antagonist no Refs
doxazosin Anticholesteremic ; Antihypertensive ; Vasodilator ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1990 small molecule antagonist yes Refs
doxazosin Anticholesteremic ; Antihypertensive ; Vasodilator ada1b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1990 small molecule antagonist yes Refs
doxazosin Anticholesteremic ; Antihypertensive ; Vasodilator ada1d_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1990 small molecule antagonist yes Refs
doxepin Hypnotics And Sedatives hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1969 small molecule antagonist yes Refs
doxepin Hypnotics And Sedatives acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1969 small molecule antagonist yes Refs
doxepin Hypnotics And Sedatives 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1969 small molecule antagonist yes Refs
doxepin Hypnotics And Sedatives acm2_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1969 small molecule antagonist yes Refs
doxepin Hypnotics And Sedatives acm3_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1969 small molecule antagonist yes Refs
doxepin Hypnotics And Sedatives acm4_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1969 small molecule antagonist yes Refs
doxepin Hypnotics And Sedatives acm5_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1969 small molecule antagonist yes Refs
doxylamine Antihistamine; For Nausea And Vomiting Of Pregnancy hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1948 small molecule antagonist no Refs
doxepin Hypnotics And Sedatives 5ht2b_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1969 small molecule antagonist yes Refs
doxepin Hypnotics And Sedatives 5ht2c_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1969 small molecule antagonist yes Refs
doxylamine Anti-Allergic ; Antiemetics; Antitussive ; Hypnotics And Sedatives hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1948 small molecule antagonist no Refs
dronabinol Analgesics cnr1_human primary A (Rhodopsin) Cannabinoid receptors approved 4 - 1985 small molecule agonist no Refs
dronabinol Appetite Stimulant cnr1_human primary A (Rhodopsin) Cannabinoid receptors approved 4 - 1985 small molecule agonist no Refs
droperidol Psychosis 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1970 small molecule antagonist no Refs
dronedarone Anti-Arrhythmia ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2009 small molecule antagonist yes Refs
dronedarone Anti-Arrhythmia adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2009 small molecule antagonist yes Refs
droperidol Adjuvants; Anesthesia drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1970 small molecule antagonist no Refs
droxidopa Orthostatic Hypotension ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2014 small molecule agonist no Refs
droxidopa Orthostatic Hypotension ada1d_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2014 small molecule agonist no Refs
droxidopa Orthostatic Hypotension ada1b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2014 small molecule agonist no Refs
droxidopa Orthostatic Hypotension adrb3_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2014 small molecule agonist no Refs
droxidopa Orthostatic Hypotension ada2a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2014 small molecule agonist no Refs
droxidopa Orthostatic Hypotension ada2b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2014 small molecule agonist no Refs
droxidopa Orthostatic Hypotension ada2c_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2014 small molecule agonist no Refs
droxidopa Orthostatic Hypotension adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2014 small molecule agonist no Refs
droxidopa Orthostatic Hypotension adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2014 small molecule agonist no Refs
dulaglutide Antidiabetic glp1r_human primary B1 (Secretin) Glucagon receptor family approved 4 - 2014 protein agonist yes Refs
eletriptan Anti-Migraine 5ht1b_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2002 small molecule agonist yes Refs
eletriptan Anti-Migraine 5ht1f_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2002 small molecule agonist yes Refs
eletriptan Anti-Migraine 5ht1d_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2002 small molecule agonist yes Refs
eluxadoline Irritable Bowel Syndrome oprd_human primary A (Rhodopsin) Opioid receptors approved 4 - 2015 small molecule agonist no Refs
eluxadoline Irritable Bowel Syndrome oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 2015 small molecule agonist no Refs
emedastine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1997 small molecule antagonist yes Refs
ephedrine Central Nervous System Stimulants ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1963 small molecule not available yes Refs
epinastine Anti-Allergic hrh2_human primary A (Rhodopsin) Histamine receptors approved 4 - 2003 small molecule antagonist yes Refs
epinastine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 2003 small molecule antagonist yes Refs
epinephrine Anesthetics ada2a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1976 small molecule agonist yes Refs
epinephrine Anesthetics adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1976 small molecule agonist yes Refs
epinephrine Anesthetics adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1976 small molecule agonist yes Refs
epinephrine Anesthetics ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1976 small molecule agonist yes Refs
epinephrine Anesthetics ada2b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1976 small molecule agonist yes Refs
epinephrine Anesthetics ada1b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1976 small molecule agonist yes Refs
epoprostenol Antihypertensive ; Platelet Aggregation Inhibitors pi2r_human primary A (Rhodopsin) Prostanoid receptors approved 4 - 1995 small molecule agonist yes Refs
eprosartan Antihypertensive agtr1_human primary A (Rhodopsin) Angiotensin receptors approved 4 - 1997 small molecule antagonist yes Refs
ergotamine Anti-Migraine ada1b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1960 small molecule agonist yes Refs
ergotamine Anti-Migraine ada1d_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1960 small molecule agonist yes Refs
ergotamine Anti-Migraine ada2c_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1960 small molecule agonist yes Refs
ergoloid Cardiovascular Disease ada1b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1953 small molecule agonist yes Refs
ergoloid Cardiovascular Disease ada1d_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1953 small molecule agonist yes Refs
ergoloid Cardiovascular Disease ada2b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1953 small molecule agonist yes Refs
ergoloid Cardiovascular Disease ada2c_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1953 small molecule agonist yes Refs
ergotamine Anti-Migraine 5ht1b_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1960 small molecule agonist yes Refs
ergoloid Nootropic ; Vasodilator ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1953 small molecule agonist yes Refs
ergoloid Nootropic ; Vasodilator ada2a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1953 small molecule agonist yes Refs
ergonovine Antihaemorrhagic ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1946 small molecule agonist yes Refs
ergotamine Anti-Migraine 5ht1d_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1960 small molecule agonist yes Refs
ergotamine Anti-Migraine ada2b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1960 small molecule agonist yes Refs
etelcalcetide Parathyroid Disorders casr_human primary C (Glutamate) Calcium-sensing receptors approved 4 - 2017 peptide agonist no Refs
ergotamine Anti-Migraine ada1a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1960 small molecule agonist yes Refs
ergotamine Anti-Migraine ada2a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1960 small molecule agonist yes Refs
esmolol Anti-Arrhythmia adrb1_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1986 small molecule antagonist no Refs
ethopropazine Antidyskinetics acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1982 small molecule antagonist no Refs
ethylmorphine Analgesics oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - - small molecule agonist no Refs
etomidate Anesthetics; Intravenous ada2b_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1982 small molecule PAM yes Refs
exenatide Antidiabetic glp1r_human primary B1 (Secretin) Glucagon receptor family approved 4 - 2005 peptide agonist yes Refs
exendin-4 Antidiabetic glp1r_human primary B1 (Secretin) Glucagon receptor family approved 4 - 2005 peptide agonist no Refs
famotidine Gastric Ulcer And Gastroesophageal Reflux hrh2_human primary A (Rhodopsin) Histamine receptors approved 4 - 1986 small molecule antagonist yes Refs
famotidine Acid Reducer hrh2_human primary A (Rhodopsin) Histamine receptors approved 4 - 1986 small molecule antagonist yes Refs
mkc-253 Antidiabetic glp1r_human primary B1 (Secretin) Glucagon receptor family in trial 1 discontinued - protein agonist no
naronapride Constipation 5ht4r_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors in trial 2 completed - small molecule agonist no
fenoldopam Antihypertensive drd1_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1997 small molecule agonist no Refs
fenoldopam Antihypertensive drd5_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1997 small molecule agonist no Refs
fenoterol Bronchodilator ; Tocolytic adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 withdrawn - small molecule agonist yes Refs
fingolimod Multiple Sclerosis s1pr5_human primary A (Rhodopsin) Lysophospholipid (S1P) receptors approved 4 - 2010 small molecule agonist yes Refs
fentanyl Adjuvant To Anesthesia oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 1968 small molecule agonist yes Refs
flavoxate Antispasmodics acm2_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1970 small molecule antagonist yes Refs
flavoxate Antispasmodics acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1970 small molecule antagonist yes Refs
flibanserin Sexual Dysfunction 5ht1a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2015 small molecule agonist no Refs
flunarizine Anticonvulsants; Vasodilator hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1968 small molecule antagonist yes Refs
fentanyl Analgesics oprm_human primary A (Rhodopsin) Opioid receptors approved 4 - 1968 small molecule agonist yes Refs
fentanyl Adjuvant To Anesthesia oprd_human primary A (Rhodopsin) Opioid receptors approved 4 - 1968 small molecule agonist yes Refs
flupentixol Antipsychotic acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1965 small molecule antagonist yes Refs
nn9924 Antidiabetic glp1r_human primary B1 (Secretin) Glucagon receptor family in trial 3 ongoing - protein agonist no
flupentixol Antipsychotic 5ht2a_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 1965 small molecule antagonist yes Refs
flupentixol Antipsychotic drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1965 small molecule antagonist yes Refs
flupentixol Antipsychotic drd1_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1965 small molecule antagonist yes Refs
fentanyl Analgesics oprd_human primary A (Rhodopsin) Opioid receptors approved 4 - 1968 small molecule agonist yes Refs
fesoterodine Prostate Adenocarcinoma acm2_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 2007 small molecule antagonist yes Refs
fesoterodine Overactive Bladder Syndrome acm3_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 2007 small molecule antagonist yes Refs
fexofenadine Anti-Allergic hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1996 small molecule antagonist yes Refs
fingolimod Multiple Sclerosis s1pr1_human primary A (Rhodopsin) Lysophospholipid (S1P) receptors approved 4 - 2010 small molecule agonist yes Refs
fluphenazine Schizophrenia drd1_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1959 small molecule antagonist yes Refs
fluphenazine Schizophrenia drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1959 small molecule antagonist yes Refs
fluphenazine decanoate Psychosis drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1972 small molecule antagonist yes Refs
fluphenazine enanthate Psychosis drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1967 small molecule antagonist no Refs
fluspirilene Schizophrenia drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1977 small molecule antagonist no Refs
forasartan Antihypertensive agtr1_human primary A (Rhodopsin) Angiotensin receptors approved 4 - - small molecule antagonist no Refs
follitropin Fertility fshr_human primary A (Rhodopsin) Glycoprotein hormone receptors approved 4 - 1997 protein agonist yes Refs
formoterol Chronic Obstructive Pulmonary Disease (Copd) adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2016 small molecule agonist yes Refs
formoterol Anti-Asthmatic adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2001 small molecule agonist yes Refs
formoterol Chronic Obstructive Pulmonary Disease (Copd) adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2001 small molecule agonist yes Refs
formoterol Bronchodilator adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2001 small molecule agonist yes Refs
formoterol Anti-Asthmatic adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2010 small molecule agonist yes Refs
formoterol Anti-Asthmatic ; Copd adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 2001 small molecule agonist yes Refs
frovatriptan Anti-Migraine 5ht1d_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2001 small molecule agonist yes Refs
frovatriptan Anti-Migraine 5ht1b_human primary A (Rhodopsin) 5-Hydroxytryptamine receptors approved 4 - 2001 small molecule agonist yes Refs
gamma hydroxybutyric acid Hypnotics And Sedatives gabr1_human primary C (Glutamate) GABAB receptors approved 4 - 2002 small molecule agonist no Refs
gamma hydroxybutyric acid Hypnotics And Sedatives gabr2_human primary C (Glutamate) GABAB receptors approved 4 - 2002 small molecule agonist no Refs
ganirelix acetate For Prevention Of Premature Ovulation In Fertility Treatment gnrhr_human primary A (Rhodopsin) Gonadotrophin-releasing hormone receptors approved 4 - 1999 small molecule antagonist no Refs
ganirelix acetate Fertility gnrhr_human primary A (Rhodopsin) Gonadotrophin-releasing hormone receptors approved 4 - 1999 small molecule antagonist no Refs
glucagon For Prevention Of Hypoglycemia glr_human primary B1 (Secretin) Glucagon receptor family approved 4 - 1960 peptide agonist yes Refs
glucagon Hypoglycemia glr_human primary B1 (Secretin) Glucagon receptor family approved 4 - 1998 peptide agonist yes Refs
glucagon Antidiabetic glr_human primary B1 (Secretin) Glucagon receptor family approved 4 - 1960 peptide agonist yes Refs
glucagon Antihypoglycemic glr_human primary B1 (Secretin) Glucagon receptor family approved 4 - 1960 peptide agonist yes Refs
glycopyrrolate Antineoplastic acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1961 small molecule antagonist no Refs
hyoscyamine Antispasmodics acm2_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - - small molecule antagonist no Refs
glycopyrrolate Chronic Obstructive Pulmonary Disease (Copd) acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1961 small molecule antagonist no Refs
glycopyrronium Chronic Obstructive Pulmonary Disease (Copd) adrb2_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1961 small molecule antagonist yes Refs
gonadorelin Fertility gnrhr_human primary A (Rhodopsin) Gonadotrophin-releasing hormone receptors approved 4 - 1982 small molecule agonist yes Refs
goserelin Antineoplastic gnrhr_human primary A (Rhodopsin) Gonadotrophin-releasing hormone receptors approved 4 - 1989 peptide agonist yes Refs
goserelin Antineoplastic S; Hormonal lshr_human primary A (Rhodopsin) Glycoprotein hormone receptors approved 4 - 1989 peptide agonist yes Refs
guanabenz Antihypertensive ada2a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1982 small molecule agonist no Refs
guanfacine Adhd ada2a_human primary A (Rhodopsin) Adrenoceptors approved 4 - 1986 small molecule agonist yes Refs
haloperidol Psychosis drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1986 small molecule antagonist yes Refs
haloperidol Schizophrenia drd2_human primary A (Rhodopsin) Dopamine receptors approved 4 - 1967 small molecule antagonist yes Refs
hexocyclium Digestive System Disease acm1_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1982 small molecule antagonist no Refs
hexocyclium Digestive System Disease acm3_human primary A (Rhodopsin) Acetylcholine receptors (muscarinic) approved 4 - 1982 small molecule antagonist no Refs
histamine Anti-Migraine hrh1_human primary A (Rhodopsin) Histamine receptors approved 4 - 1939 small molecule agonist no