SELECT A RECEPTOR in the table and click a green button
The next page shows plots for the ligand pathway profiles ΔLog(Emax/EC50) by transducer or effector family across publications.
Physiology-bias, pathway-bias and benchmark-bias is explained in the article Community Guidelines for GPCR Ligand Bias.
*Biased ligands have a bias factor ≥ 5.
| Receptor classification | Number of ligands | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Class | Ligand type | Family | Species | Receptor (UniProt) | Receptor (GtP) | Tested (total) | Balanced references | Pathway biased * | Physiology biased * | |
| A | Aminergic | 5-Hydroxytryptamine | Homo sapiens | 24 | - | - | - | |||
| A | Aminergic | 5-Hydroxytryptamine | Homo sapiens | 12 | - | - | - | |||
| A | Aminergic | 5-Hydroxytryptamine | Homo sapiens | 11 | - | - | - | |||
| A | Aminergic | 5-Hydroxytryptamine | Homo sapiens | 20 | - | - | - | |||
| A | Aminergic | 5-Hydroxytryptamine | Homo sapiens | 32 | - | - | - | |||
| A | Aminergic | 5-Hydroxytryptamine | Homo sapiens | 6 | - | - | - | |||
| A | Aminergic | Acetylcholine (muscarinic) | Homo sapiens | 14 | - | - | - | |||
| A | Aminergic | Acetylcholine (muscarinic) | Homo sapiens | 22 | - | - | - | |||
| A | Aminergic | Dopamine | Homo sapiens | 319 | 2 | 8 | 9 | |||
| A | Aminergic | Acetylcholine (muscarinic) | Homo sapiens | 8 | - | - | - | |||
| A | Aminergic | Acetylcholine (muscarinic) | Homo sapiens | 5 | - | - | - | |||
| A | Aminergic | Acetylcholine (muscarinic) | Homo sapiens | 5 | - | - | - | |||
| A | Aminergic | Adrenoceptors | Homo sapiens | 8 | - | - | - | |||
| A | Aminergic | Adrenoceptors | Homo sapiens | 8 | - | - | 2 | |||
| A | Aminergic | Adrenoceptors | Homo sapiens | 25 | - | - | 1 | |||
| A | Aminergic | Adrenoceptors | Homo sapiens | 67 | - | - | - | |||
| A | Aminergic | Dopamine | Homo sapiens | 129 | 1 | - | 1 | |||
| A | Aminergic | Dopamine | Homo sapiens | 28 | 1 | - | 1 | |||
| A | Aminergic | Dopamine | Homo sapiens | 6 | - | - | - | |||
| A | Aminergic | Histamine | Homo sapiens | 5 | - | - | - | |||
| A | Aminergic | Histamine | Homo sapiens | 31 | - | - | - | |||
| A | Peptide | Angiotensin | Homo sapiens | 27 | - | - | - | |||
| A | Peptide | Apelin | Homo sapiens | 54 | 1 | - | 7 | |||
| A | Peptide | Complement peptide | Homo sapiens | 2 | - | - | - | |||
| A | Peptide | Endothelin | Homo sapiens | 4 | - | - | - | |||
| A | Peptide | Formylpeptide | Homo sapiens | 13 | - | - | - | |||
| A | Peptide | Formylpeptide | Homo sapiens | 6 | - | - | - | |||
| A | Peptide | Galanin | Homo sapiens | 3 | - | - | - | |||
| A | Peptide | Ghrelin | Homo sapiens | 17 | 1 | - | - | |||
| A | Peptide | Melanocortin | Homo sapiens | 4 | - | - | - | |||
| A | Peptide | Melanocortin | Homo sapiens | 4 | - | - | - | |||
| A | Peptide | Melanocortin | Homo sapiens | 4 | - | - | - | |||
| A | Peptide | Melanocortin | Homo sapiens | 4 | - | - | - | |||
| A | Peptide | Neuropeptide S | Homo sapiens | 6 | - | - | - | |||
| A | Peptide | Neuropeptide Y | Homo sapiens | 4 | - | - | - | |||
| A | Peptide | Opioid | Homo sapiens | 82 | 1 | - | 5 | |||
| A | Peptide | Opioid | Homo sapiens | 123 | - | - | - | |||
| A | Peptide | Opioid | Homo sapiens | 310 | 8 | 1 | 6 | |||
| A | Peptide | Opioid | Homo sapiens | 28 | - | - | 1 | |||
| A | Peptide | Proteinase-activated | Homo sapiens | 2 | - | - | - | |||
| A | Peptide | Relaxin family peptide | Homo sapiens | 2 | - | - | - | |||
| A | Peptide | Vasopressin and oxytocin | Homo sapiens | 2 | - | - | - | |||
| A | Peptide | Vasopressin and oxytocin | Homo sapiens | 2 | - | - | - | |||
| A | Peptide | Vasopressin and oxytocin | Homo sapiens | 2 | - | - | - | |||
| A | Peptide | Vasopressin and oxytocin | Homo sapiens | 2 | - | - | - | |||
| A | Protein | Chemokine | Homo sapiens | 11 | 1 | - | - | |||
| A | Protein | Chemokine | Homo sapiens | 3 | - | - | - | |||
| A | Protein | Chemokine | Homo sapiens | 7 | 1 | - | - | |||
| A | Protein | Chemokine | Homo sapiens | 2 | - | - | - | |||
| A | Protein | Chemokine | Homo sapiens | 3 | - | - | - | |||
| A | Protein | Chemokine | Homo sapiens | 6 | - | - | - | |||
| A | Protein | Chemokine | Homo sapiens | 33 | 1 | - | - | |||
| A | Protein | Chemokine | Homo sapiens | 2 | - | - | - | |||
| A | Protein | Glycoprotein hormone | Homo sapiens | 4 | - | - | - | |||
| A | Lipid | Free fatty acid | Homo sapiens | 9 | 1 | - | - | |||
| A | Lipid | Lysophospholipid (LPA) | Homo sapiens | 10 | - | - | - | |||
| A | Lipid | Lysophospholipid (S1P) | Homo sapiens | 2 | - | - | - | |||
| A | Lipid | Cannabinoid | Homo sapiens | 48 | 2 | - | - | |||
| A | Lipid | Cannabinoid | Homo sapiens | 46 | 1 | 1 | 16 | |||
| A | Lipid | Prostanoid | Homo sapiens | 39 | - | - | - | |||
| A | Lipid | Prostanoid | Homo sapiens | 11 | - | - | - | |||
| A | Nucleotide | Adenosine | Homo sapiens | 34 | - | - | - | |||
| A | Nucleotide | Adenosine | Homo sapiens | 11 | - | - | - | |||
| A | Nucleotide | Adenosine | Homo sapiens | 55 | 1 | - | - | |||
| A | Orphan | A orphans | Homo sapiens | 77 | - | - | - | |||
| B1 | Peptide | Calcitonin | Homo sapiens | 8 | - | - | - | |||
| B1 | Peptide | Calcitonin | Homo sapiens | 19 | - | - | - | |||
| B1 | Peptide | Glucagon | Homo sapiens | 60 | - | - | - | |||
| B1 | Peptide | Glucagon | Homo sapiens | 1 | - | - | - | |||
| A | Lipid | Cannabinoid | Mus musculus | 39 | - | - | - | |||
| A | Peptide | Opioid | Rattus norvegicus | 24 | - | - | 2 | |||
| A | Peptide | Opioid | Mus musculus | 43 | - | - | - | |||
| B1 | Peptide | Glucagon | Mus musculus | 7 | - | - | - | |||
| A | Peptide | Opioid | Mus musculus | 42 | - | - | - | |||
| A | Aminergic | Dopamine | Mus musculus | 21 | - | - | - | |||
| A | Nucleotide | Adenosine | Mus musculus | 8 | - | - | - | |||
| C | Ion | Calcium-sensing | Rattus norvegicus | 10 | - | - | - | |||
| B1 | Peptide | Glucagon | Rattus norvegicus | 17 | - | - | - | |||
| A | Peptide | Opioid | Mus musculus | 43 | - | - | - | |||
| A | Peptide | Opioid | Canis lupus familiaris | 1 | - | - | - | |||