Ligand source activities (1 row/activity)





Ligands Receptor Assay information Chemical information
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name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Potency)
# tested GPCRs
(Potency)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
53322111 64140 0 None 125 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 482 7 4 8 3.4 C#CCNC(=O)CNc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 10.1021/ml100229v
CHEMBL1651721 64140 0 None 125 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 482 7 4 8 3.4 C#CCNC(=O)CNc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 10.1021/ml100229v
53320793 64142 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1136 18 5 17 10.1 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651723 64142 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1136 18 5 17 10.1 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
11618319 86554 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 403 4 1 8 4.6 COc1cccc(-c2nc(SC)nc3sc(C(=O)OC(C)(C)C)c(N)c23)c1 10.1021/jm060247s
CHEMBL211871 86554 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 403 4 1 8 4.6 COc1cccc(-c2nc(SC)nc3sc(C(=O)OC(C)(C)C)c(N)c23)c1 10.1021/jm060247s
11509369 86783 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 390 3 2 6 4.3 CSc1nc(-c2cccc(F)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/jm060247s
CHEMBL212815 86783 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 390 3 2 6 4.3 CSc1nc(-c2cccc(F)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/jm060247s
44440750 104102 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 610 13 3 7 6.2 CC(C)(C)Oc1ccc(C[C@H](NC(=O)CCCCNc2cc(-c3cccnc3)nn2-c2ccc(C(C)(C)C)cc2)C(N)=O)cc1 10.1016/j.bmcl.2006.12.062
CHEMBL269261 104102 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 610 13 3 7 6.2 CC(C)(C)Oc1ccc(C[C@H](NC(=O)CCCCNc2cc(-c3cccnc3)nn2-c2ccc(C(C)(C)C)cc2)C(N)=O)cc1 10.1016/j.bmcl.2006.12.062
44440752 175806 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 568 13 4 7 5.1 CC(C)(C)c1ccc(-n2nc(-c3ccccn3)cc2NCCCCCC(=O)N[C@@H](Cc2cccc(O)c2)C(N)=O)cc1 10.1016/j.bmcl.2006.12.062
CHEMBL439392 175806 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 568 13 4 7 5.1 CC(C)(C)c1ccc(-n2nc(-c3ccccn3)cc2NCCCCCC(=O)N[C@@H](Cc2cccc(O)c2)C(N)=O)cc1 10.1016/j.bmcl.2006.12.062
11502667 85191 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 420 4 2 7 4.3 COc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1F 10.1021/jm060247s
CHEMBL211129 85191 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 420 4 2 7 4.3 COc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1F 10.1021/jm060247s
44572264 186217 19 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human luteinizing hormone receptor expressed in CHOK1 cells assessed as c-AMP-mediated luciferase productionAgonist activity at human luteinizing hormone receptor expressed in CHOK1 cells assessed as c-AMP-mediated luciferase production
ChEMBL 357 4 1 2 6.1 O=C(NC1CCCC1)Oc1cc(-c2ccccc2)cc(-c2ccccc2)c1 10.1021/jm801561h
CHEMBL474041 186217 19 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human luteinizing hormone receptor expressed in CHOK1 cells assessed as c-AMP-mediated luciferase productionAgonist activity at human luteinizing hormone receptor expressed in CHOK1 cells assessed as c-AMP-mediated luciferase production
ChEMBL 357 4 1 2 6.1 O=C(NC1CCCC1)Oc1cc(-c2ccccc2)cc(-c2ccccc2)c1 10.1021/jm801561h
44440751 100603 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 554 12 4 7 5.3 CC(C)(C)c1ccc(-n2nc(-c3ccccn3)cc2NCCCCCC(=O)N[C@H](C(N)=O)c2ccc(O)cc2)cc1 10.1016/j.bmcl.2006.12.062
CHEMBL247700 100603 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 554 12 4 7 5.3 CC(C)(C)c1ccc(-n2nc(-c3ccccn3)cc2NCCCCCC(=O)N[C@H](C(N)=O)c2ccc(O)cc2)cc1 10.1016/j.bmcl.2006.12.062
44440753 155300 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 537 12 2 5 5.5 CC(C)(C)c1ccc(-n2nc(-c3ccncc3)cc2CCCCC(=O)N[C@H](CC(N)=O)Cc2ccccc2)cc1 10.1016/j.bmcl.2006.12.062
CHEMBL393847 155300 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 537 12 2 5 5.5 CC(C)(C)c1ccc(-n2nc(-c3ccncc3)cc2CCCCC(=O)N[C@H](CC(N)=O)Cc2ccccc2)cc1 10.1016/j.bmcl.2006.12.062
11531195 145576 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 388 3 3 7 3.9 CSc1nc(-c2cccc(O)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/jm060247s
CHEMBL378091 145576 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 388 3 3 7 3.9 CSc1nc(-c2cccc(O)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/jm060247s
9915237 100298 1 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 539 11 3 6 4.9 CC(C)(C)c1ccc(-n2nc(-c3cccnc3)cc2CCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)cc1 10.1016/j.bmcl.2006.12.062
CHEMBL246321 100298 1 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 539 11 3 6 4.9 CC(C)(C)c1ccc(-n2nc(-c3cccnc3)cc2CCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)cc1 10.1016/j.bmcl.2006.12.062
44440784 100153 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 539 11 3 6 4.9 CC(C)(C)c1ccc(-n2nc(CCCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)cc2-c2ccncc2)cc1 10.1016/j.bmcl.2006.12.062
CHEMBL245663 100153 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 539 11 3 6 4.9 CC(C)(C)c1ccc(-n2nc(CCCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)cc2-c2ccncc2)cc1 10.1016/j.bmcl.2006.12.062
53320759 64159 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1136 18 5 17 10.1 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651829 64159 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1136 18 5 17 10.1 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
44440746 159506 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 539 11 3 6 4.9 CC(C)(C)c1ccc(-n2nc(-c3ccncc3)cc2CCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)cc1 10.1016/j.bmcl.2006.12.062
CHEMBL397316 159506 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 539 11 3 6 4.9 CC(C)(C)c1ccc(-n2nc(-c3ccncc3)cc2CCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)cc1 10.1016/j.bmcl.2006.12.062
53323417 64153 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1180 21 5 18 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651823 64153 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1180 21 5 18 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
9887381 86306 24 None 27 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 402 4 2 7 4.2 COc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 10.1021/jm060247s
CHEMBL211405 86306 24 None 27 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 402 4 2 7 4.2 COc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 10.1021/jm060247s
53324744 64162 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1313 30 5 21 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651831 64162 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1313 30 5 21 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
53320758 64154 0 None 21 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1225 24 5 19 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651824 64154 0 None 21 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1225 24 5 19 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
44255904 64158 0 None 79 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 682 17 4 14 3.9 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCN=[N+]=[N-])nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651828 64158 0 None 79 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 682 17 4 14 3.9 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCN=[N+]=[N-])nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
44440748 100643 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 609 8 3 6 6.6 CC(C)(C)c1ccc(-n2nc(-c3cc4ccccc4cn3)cc2-c2cccc(C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)c2)cc1 10.1016/j.bmcl.2006.12.062
CHEMBL247945 100643 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 609 8 3 6 6.6 CC(C)(C)c1ccc(-n2nc(-c3cc4ccccc4cn3)cc2-c2cccc(C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)c2)cc1 10.1016/j.bmcl.2006.12.062
53324743 64156 0 None 18 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1313 30 5 21 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651826 64156 0 None 18 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1313 30 5 21 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
53318121 64152 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1269 27 5 20 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651822 64152 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1269 27 5 20 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
53324742 64155 0 None 26 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1269 27 5 20 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651825 64155 0 None 26 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1269 27 5 20 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
53324741 64151 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1225 24 5 19 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651821 64151 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1225 24 5 19 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
44440754 173946 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 496 10 2 5 6.0 CC(C)(C)c1ccc(-n2nc(-c3cccnc3)cc2CCCCC(=O)NCCc2ccc(O)cc2)cc1 10.1016/j.bmcl.2006.12.062
CHEMBL429108 173946 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPAAgonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA
ChEMBL 496 10 2 5 6.0 CC(C)(C)c1ccc(-n2nc(-c3cccnc3)cc2CCCCC(=O)NCCc2ccc(O)cc2)cc1 10.1016/j.bmcl.2006.12.062
53320760 64161 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1180 21 5 18 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651830 64161 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 1180 21 5 18 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCn4cc(COc5ccc([C@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
11654606 145198 1 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 416 4 1 7 4.5 COc1cccc(-c2nc(SC)nc3sc(C(=O)N(C)C(C)(C)C)c(N)c23)c1 10.1021/jm060247s
CHEMBL377399 145198 1 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 416 4 1 7 4.5 COc1cccc(-c2nc(SC)nc3sc(C(=O)N(C)C(C)(C)C)c(N)c23)c1 10.1021/jm060247s
11539288 145449 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 432 5 2 8 4.2 COc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1OC 10.1021/jm060247s
CHEMBL377769 145449 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulationAgonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
ChEMBL 432 5 2 8 4.2 COc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1OC 10.1021/jm060247s
155566723 182703 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 457 4 1 3 6.3 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4587440 182703 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 457 4 1 3 6.3 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01382
155563159 182091 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 398 3 1 3 5.6 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4573509 182091 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 398 3 1 3 5.6 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b01382
155546314 180323 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 478 4 1 3 7.5 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2sccc2C1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4531781 180323 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 478 4 1 3 7.5 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2sccc2C1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
155558589 181531 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 402 2 1 2 6.2 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccccc1 10.1021/acs.jmedchem.9b01382
CHEMBL4560733 181531 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 402 2 1 2 6.2 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccccc1 10.1021/acs.jmedchem.9b01382
155524816 177778 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 425 4 2 4 4.2 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2ccc(F)c(C(N)=O)c2)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4456365 177778 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 425 4 2 4 4.2 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2ccc(F)c(C(N)=O)c2)cc1 10.1021/acs.jmedchem.9b01382
155516839 176887 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 420 2 1 2 6.4 O=C(Nc1ccc(F)c(Cl)c1)N1CCc2sccc2C1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4443605 176887 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 420 2 1 2 6.4 O=C(Nc1ccc(F)c(Cl)c1)N1CCc2sccc2C1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
139600336 177916 14 None -4 3 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 459 4 1 5 5.1 O=C(Nc1cnc(Oc2ccc(F)cc2)nc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4458424 177916 14 None -4 3 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 459 4 1 5 5.1 O=C(Nc1cnc(Oc2ccc(F)cc2)nc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01382
155530584 178333 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 438 2 1 2 6.5 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccc(F)c(F)c1 10.1021/acs.jmedchem.9b01382
CHEMBL4464604 178333 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 438 2 1 2 6.5 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccc(F)c(F)c1 10.1021/acs.jmedchem.9b01382
155528786 178160 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 394 4 1 4 4.9 COc1cc(NC(=O)N2CCc3sccc3[C@@H]2c2ccccc2)cc(OC)c1 10.1021/acs.jmedchem.9b01382
CHEMBL4461980 178160 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 394 4 1 4 4.9 COc1cc(NC(=O)N2CCc3sccc3[C@@H]2c2ccccc2)cc(OC)c1 10.1021/acs.jmedchem.9b01382
155542952 179965 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 424 5 1 5 5.0 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(OC)cc(OC)c2)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4522381 179965 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 424 5 1 5 5.0 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(OC)cc(OC)c2)cc1 10.1021/acs.jmedchem.9b01382
2741928 182960 4 None 1 2 Rat 6.7 pIC50 = 6.7 Functional
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
ChEMBL 432 3 1 3 6.2 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4593222 182960 4 None 1 2 Rat 6.7 pIC50 = 6.7 Functional
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
ChEMBL 432 3 1 3 6.2 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
139600337 180572 12 None 28 3 Rat 7.6 pIC50 = 7.6 Functional
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4537998 180572 12 None 28 3 Rat 7.6 pIC50 = 7.6 Functional
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
155555227 181132 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 419 2 2 3 4.9 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccc(=O)[nH]c1 10.1021/acs.jmedchem.9b01382
CHEMBL4551301 181132 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 419 2 2 3 4.9 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccc(=O)[nH]c1 10.1021/acs.jmedchem.9b01382
155532999 178582 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 416 2 1 2 6.5 Cc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4468163 178582 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 416 2 1 2 6.5 Cc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
155561384 182463 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 398 3 1 3 5.6 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cccc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4581889 182463 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 398 3 1 3 5.6 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cccc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
155555948 181292 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 458 4 1 4 5.7 O=C(Nc1ccc(Oc2ccc(F)cc2)nc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4555151 181292 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 458 4 1 4 5.7 O=C(Nc1ccc(Oc2ccc(F)cc2)nc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01382
155567488 182733 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 420 2 1 2 6.4 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1cccc(F)c1 10.1021/acs.jmedchem.9b01382
CHEMBL4588196 182733 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 420 2 1 2 6.4 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1cccc(F)c1 10.1021/acs.jmedchem.9b01382
155564366 181934 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 420 2 1 2 6.4 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccccc1F 10.1021/acs.jmedchem.9b01382
CHEMBL4570127 181934 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 420 2 1 2 6.4 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccccc1F 10.1021/acs.jmedchem.9b01382
155565197 182353 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 460 4 1 3 7.4 O=C(Nc1cccc(Oc2ccccc2)c1)N1CCc2sccc2C1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4579421 182353 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 460 4 1 3 7.4 O=C(Nc1cccc(Oc2ccccc2)c1)N1CCc2sccc2C1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
155535600 178830 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 440 5 1 5 5.1 COc1ccc(C2c3ccsc3CCN2C(=S)Nc2cc(OC)cc(OC)c2)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4471875 178830 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 440 5 1 5 5.1 COc1ccc(C2c3ccsc3CCN2C(=S)Nc2cc(OC)cc(OC)c2)cc1 10.1021/acs.jmedchem.9b01382
155533073 178591 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 470 2 1 2 7.3 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4468307 178591 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 470 2 1 2 7.3 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.9b01382
2741928 182960 4 None -1 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 432 3 1 3 6.2 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4593222 182960 4 None -1 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 432 3 1 3 6.2 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
29993669 178803 1 None 1 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 432 3 1 3 6.2 COc1ccc([C@H]2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4471621 178803 1 None 1 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 432 3 1 3 6.2 COc1ccc([C@H]2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
29993669 178803 1 None -1 2 Rat 6.4 pIC50 = 6.4 Functional
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
ChEMBL 432 3 1 3 6.2 COc1ccc([C@H]2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4471621 178803 1 None -1 2 Rat 6.4 pIC50 = 6.4 Functional
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
ChEMBL 432 3 1 3 6.2 COc1ccc([C@H]2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
139600336 177916 14 None 4 3 Rat 7.3 pIC50 = 7.3 Functional
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
ChEMBL 459 4 1 5 5.1 O=C(Nc1cnc(Oc2ccc(F)cc2)nc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4458424 177916 14 None 4 3 Rat 7.3 pIC50 = 7.3 Functional
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
ChEMBL 459 4 1 5 5.1 O=C(Nc1cnc(Oc2ccc(F)cc2)nc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01382
155568207 182851 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 436 2 1 2 6.9 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4590976 182851 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 436 2 1 2 6.9 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
29993670 177312 1 None 1 2 Rat 5.3 pIC50 = 5.3 Functional
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
ChEMBL 432 3 1 3 6.2 COc1ccc([C@@H]2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4449797 177312 1 None 1 2 Rat 5.3 pIC50 = 5.3 Functional
Antagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assayAntagonist activity at rat luteinizing hormone receptor expressed in rat ovary granulosa GLHR15 cell suspension assessed as reduction in agonist-induced cAMP production preincubated for 30 mins followed by agonist solution addition after 30 mins by cell based TR-FRET assay
ChEMBL 432 3 1 3 6.2 COc1ccc([C@@H]2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
155563505 182089 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 403 2 1 3 5.6 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccncc1 10.1021/acs.jmedchem.9b01382
CHEMBL4573451 182089 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 403 2 1 3 5.6 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1ccncc1 10.1021/acs.jmedchem.9b01382
155561534 182418 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 392 3 1 3 5.6 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(C)cc(C)c2)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4580951 182418 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 392 3 1 3 5.6 COc1ccc(C2c3ccsc3CCN2C(=O)Nc2cc(C)cc(C)c2)cc1 10.1021/acs.jmedchem.9b01382
29993670 177312 1 None -1 2 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 432 3 1 3 6.2 COc1ccc([C@@H]2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4449797 177312 1 None -1 2 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 432 3 1 3 6.2 COc1ccc([C@@H]2c3ccsc3CCN2C(=O)Nc2cc(Cl)cc(Cl)c2)cc1 10.1021/acs.jmedchem.9b01382
155534855 178767 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 403 2 1 3 5.6 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1cccnc1 10.1021/acs.jmedchem.9b01382
CHEMBL4471103 178767 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 403 2 1 3 5.6 O=C(Nc1cc(Cl)cc(Cl)c1)N1CCc2sccc2C1c1cccnc1 10.1021/acs.jmedchem.9b01382
155527311 178031 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 470 3 1 3 6.6 O=C(Nc1ccc(F)c(OC(F)(F)F)c1)N1CCc2sccc2C1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4460075 178031 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 470 3 1 3 6.6 O=C(Nc1ccc(F)c(OC(F)(F)F)c1)N1CCc2sccc2C1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
57325683 81728 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 368 2 1 2 5.6 O=C(Nc1ccccc1)N1CCc2sccc2C1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL2032175 81728 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 368 2 1 2 5.6 O=C(Nc1ccccc1)N1CCc2sccc2C1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
139600337 180572 12 None -28 3 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4537998 180572 12 None -28 3 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assayAntagonist activity at human luteinizing hormone receptor assessed as reduction in agonist-induced cAMP production preincubated for 20 mins followed by agonist solution addition after 60 mins by cell based TR-FRET assay
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL412984 219817 0 None - 0 Rat 9.4 pKd = 9.4 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL None None None CC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O 10.1021/jm00130a019
44314940 88890 0 None - 0 Rat 9.3 pKd = 9.3 Functional
Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 1041 26 10 10 2.8 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL216617 88890 0 None - 0 Rat 9.3 pKd = 9.3 Functional
Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 1041 26 10 10 2.8 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
44315218 105220 0 None - 0 Rat 8.7 pKd = 8.7 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1030 26 11 10 2.1 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL275694 105220 0 None - 0 Rat 8.7 pKd = 8.7 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1030 26 11 10 2.1 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
44314845 168674 0 None - 0 Rat 8.0 pKd = 8.0 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1067 28 9 10 3.4 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL415109 168674 0 None - 0 Rat 8.0 pKd = 8.0 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1067 28 9 10 3.4 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
44314939 168112 0 None - 0 Rat 7.9 pKd = 7.9 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1032 26 11 11 1.5 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)COc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL412573 168112 0 None - 0 Rat 7.9 pKd = 7.9 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1032 26 11 11 1.5 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)COc1cccc2ccccc12 10.1021/jm00130a019
14557614 96153 0 None - 0 Rat 7.8 pKd = 7.8 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 977 25 10 10 1.2 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369800 96153 0 None - 0 Rat 7.8 pKd = 7.8 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 977 25 10 10 1.2 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369798 216469 0 None - 0 Rat 7.8 pKd = 7.8 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1ccc2ccccc2c1 10.1021/jm00130a019
14557592 96149 0 None - 0 Rat 6.7 pKd = 6.7 Functional
In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 918 24 11 10 0.4 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369791 96149 0 None - 0 Rat 6.7 pKd = 6.7 Functional
In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 918 24 11 10 0.4 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00130a019
14557629 96156 0 None - 0 Rat 5.7 pKd = 5.7 Functional
In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 906 25 10 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1cccnc1 10.1021/jm00130a019
CHEMBL2369809 96156 0 None - 0 Rat 5.7 pKd = 5.7 Functional
In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 906 25 10 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1cccnc1 10.1021/jm00130a019
14557620 96157 0 None - 0 Rat 6.7 pKd = 6.7 Functional
In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 955 25 10 10 1.5 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369810 96157 0 None - 0 Rat 6.7 pKd = 6.7 Functional
In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 955 25 10 10 1.5 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1cccc2ccccc12 10.1021/jm00130a019
44314797 174180 0 None - 0 Rat 7.6 pKd = 7.6 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1030 26 11 10 2.1 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL429543 174180 0 None - 0 Rat 7.6 pKd = 7.6 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1030 26 11 10 2.1 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
14557600 96158 0 None - 0 Rat 6.6 pKd = 6.6 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 957 26 10 10 1.4 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369813 96158 0 None - 0 Rat 6.6 pKd = 6.6 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 957 26 10 10 1.4 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
14557594 96148 0 None - 0 Rat 5.6 pKd = 5.6 Functional
In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 932 25 11 10 0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369790 96148 0 None - 0 Rat 5.6 pKd = 5.6 Functional
In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)In vivo luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 932 25 11 10 0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
44314843 103505 0 None - 0 Rat 8.5 pKd = 8.5 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1106 28 10 10 3.9 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL264298 103505 0 None - 0 Rat 8.5 pKd = 8.5 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1106 28 10 10 3.9 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
44314937 103637 0 None - 0 Rat 8.5 pKd = 8.5 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1024 25 11 10 1.9 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CC12CC3CC(CC(C3)C1)C2 10.1021/jm00130a019
CHEMBL265413 103637 0 None - 0 Rat 8.5 pKd = 8.5 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1024 25 11 10 1.9 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CC12CC3CC(CC(C3)C1)C2 10.1021/jm00130a019
44314846 105048 0 None - 0 Rat 8.4 pKd = 8.4 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1117 28 9 10 4.6 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL274609 105048 0 None - 0 Rat 8.4 pKd = 8.4 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1117 28 9 10 4.6 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
44314897 167239 0 None - 0 Rat 7.5 pKd = 7.5 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1033 28 9 10 3.2 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL411175 167239 0 None - 0 Rat 7.5 pKd = 7.5 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1033 28 9 10 3.2 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369793 216468 0 None - 0 Rat 6.5 pKd = 6.5 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1ccc(OC)cc1 10.1021/jm00130a019
14557590 96155 0 None - 0 Rat 6.4 pKd = 6.4 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 986 26 11 10 1.7 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369808 96155 0 None - 0 Rat 6.4 pKd = 6.4 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 986 26 11 10 1.7 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
44315053 105224 0 None - 0 Rat 8.2 pKd = 8.2 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1027 25 10 10 2.4 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL275709 105224 0 None - 0 Rat 8.2 pKd = 8.2 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1027 25 10 10 2.4 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369807 216470 0 None - 0 Rat 8.2 pKd = 8.2 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369787 216466 0 None - 0 Rat 7.2 pKd = 7.2 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C\c1ccc(OC)cc1 10.1021/jm00130a019
44314898 148633 0 None - 0 Rat 7.1 pKd = 7.1 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1120 29 10 10 4.3 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL386525 148633 0 None - 0 Rat 7.1 pKd = 7.1 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1120 29 10 10 4.3 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
44315220 168532 0 None - 0 Rat 8.1 pKd = 8.1 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1044 27 11 10 2.5 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCCc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL413887 168532 0 None - 0 Rat 8.1 pKd = 8.1 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 1044 27 11 10 2.5 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCCc1c[nH]c2ccccc12 10.1021/jm00130a019
14557616 96151 0 None - 0 Rat 6.1 pKd = 6.1 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 983 25 10 10 1.9 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369799 96151 0 None - 0 Rat 6.1 pKd = 6.1 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 983 25 10 10 1.9 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
14557588 96154 0 None - 0 Rat 6.1 pKd = 6.1 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 980 26 11 10 0.9 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369806 96154 0 None - 0 Rat 6.1 pKd = 6.1 Functional
In vivo inhibition of leutenising hormone in rats.In vivo inhibition of leutenising hormone in rats.
ChEMBL 980 26 11 10 0.9 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
1159 9097 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12727981
1159 9097 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1922095
CHEMBL1201419 9097 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12727981
CHEMBL1201419 9097 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1922095
DB00044 9097 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12727981
DB00044 9097 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1922095




Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Affinity)
# tested GPCRs
(Affinity)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
9887381 86306 24 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at LHCGR (unknown origin)Agonist activity at LHCGR (unknown origin)
ChEMBL 402 4 2 7 4.2 COc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 10.1039/c1md00145k
CHEMBL211405 86306 24 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at LHCGR (unknown origin)Agonist activity at LHCGR (unknown origin)
ChEMBL 402 4 2 7 4.2 COc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 10.1039/c1md00145k
139600337 180572 12 None - 0 Human 5.9 pIC50 = 5.9 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 4 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 4 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4537998 180572 12 None - 0 Human 5.9 pIC50 = 5.9 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 4 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 4 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
139600337 180572 12 None - 0 Human 5.8 pIC50 = 5.8 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 10 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 10 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4537998 180572 12 None - 0 Human 5.8 pIC50 = 5.8 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 10 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 10 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
139600337 180572 12 None - 0 Human 5.8 pIC50 = 5.8 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 100 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 100 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4537998 180572 12 None - 0 Human 5.8 pIC50 = 5.8 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 100 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 100 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
139600337 180572 12 None - 0 Human 5.8 pIC50 = 5.8 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 16 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 16 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4537998 180572 12 None - 0 Human 5.8 pIC50 = 5.8 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 16 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 16 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
139600336 177916 14 None - 1 Human 6.7 pIC50 = 6.7 Binding
Affinity On-target Cellular interaction (Cell-based assay (LH Antagonism)) EUB0000240b LHCGRAffinity On-target Cellular interaction (Cell-based assay (LH Antagonism)) EUB0000240b LHCGR
ChEMBL 459 4 1 5 5.1 O=C(Nc1cnc(Oc2ccc(F)cc2)nc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1 10.6019/CHEMBL5210121
CHEMBL4458424 177916 14 None - 1 Human 6.7 pIC50 = 6.7 Binding
Affinity On-target Cellular interaction (Cell-based assay (LH Antagonism)) EUB0000240b LHCGRAffinity On-target Cellular interaction (Cell-based assay (LH Antagonism)) EUB0000240b LHCGR
ChEMBL 459 4 1 5 5.1 O=C(Nc1cnc(Oc2ccc(F)cc2)nc1)N1CCc2ncccc2[C@@H]1c1ccc(F)cc1 10.6019/CHEMBL5210121
139600337 180572 12 None - 0 Human 6.7 pIC50 = 6.7 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 4 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 4 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4537998 180572 12 None - 0 Human 6.7 pIC50 = 6.7 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 4 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 4 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
139600337 180572 12 None - 0 Human 5.7 pIC50 = 5.7 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 10 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 10 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4537998 180572 12 None - 0 Human 5.7 pIC50 = 5.7 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 10 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 10 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
139600337 180572 12 None - 0 Human 5.7 pIC50 = 5.7 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 16 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 16 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4537998 180572 12 None - 0 Human 5.7 pIC50 = 5.7 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 16 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 16 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
44572264 186217 19 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [3H]Org43553 from human luteinizing hormone receptor expressed in CHOK1 cellsDisplacement of [3H]Org43553 from human luteinizing hormone receptor expressed in CHOK1 cells
ChEMBL 357 4 1 2 6.1 O=C(NC1CCCC1)Oc1cc(-c2ccccc2)cc(-c2ccccc2)c1 10.1021/jm801561h
CHEMBL474041 186217 19 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [3H]Org43553 from human luteinizing hormone receptor expressed in CHOK1 cellsDisplacement of [3H]Org43553 from human luteinizing hormone receptor expressed in CHOK1 cells
ChEMBL 357 4 1 2 6.1 O=C(NC1CCCC1)Oc1cc(-c2ccccc2)cc(-c2ccccc2)c1 10.1021/jm801561h
139600337 180572 12 None - 0 Human 5.6 pIC50 = 5.6 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 100 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 100 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4537998 180572 12 None - 0 Human 5.6 pIC50 = 5.6 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 100 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 100 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
139600337 180572 12 None - 0 Human 6.2 pIC50 = 6.2 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 1 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 1 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4537998 180572 12 None - 0 Human 6.2 pIC50 = 6.2 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 1 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in Org 43553-induced agonist activity preincubated for 20 mins followed by 1 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
139600337 180572 12 None - 0 Human 7.0 pIC50 = 7.0 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 1 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 1 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
CHEMBL4537998 180572 12 None - 0 Human 7.0 pIC50 = 7.0 Binding
Negative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 1 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to controlNegative allosteric modulation of human luteinizing hormone receptor assessed as reduction in glycoprotein human luteinizing hormone-induced agonist activity preincubated for 20 mins followed by 1 times EC80 of agonist addition and measured after 60 mins by cell based TR-FRET assay relative to control
ChEMBL 473 4 1 3 6.8 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@@H]1c1ccc(Cl)cc1 10.1021/acs.jmedchem.9b01382
44267887 105257 0 None 5 3 Rat 9.9 pKd = 9.9 Binding
In vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cellsIn vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cells
ChEMBL 967 10 1 14 7.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C3CCCC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C 10.1021/jm030418i
CHEMBL275935 105257 0 None 5 3 Rat 9.9 pKd = 9.9 Binding
In vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cellsIn vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cells
ChEMBL 967 10 1 14 7.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C3CCCC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C 10.1021/jm030418i
44267907 23103 0 None -4 3 Rat 9.3 pKd = 9.3 Binding
In vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cellsIn vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cells
ChEMBL 937 11 1 14 6.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(F)c(Cl)c3)C(=O)O[C@]12C 10.1021/jm030418i
CHEMBL12282 23103 0 None -4 3 Rat 9.3 pKd = 9.3 Binding
In vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cellsIn vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cells
ChEMBL 937 11 1 14 6.8 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(F)c(Cl)c3)C(=O)O[C@]12C 10.1021/jm030418i
9854500 109049 0 None -1 3 Rat 8.8 pKd = 8.8 Binding
In vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cellsIn vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cells
ChEMBL 953 11 1 14 7.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C 10.1021/jm030418i
CHEMBL303274 109049 0 None -1 3 Rat 8.8 pKd = 8.8 Binding
In vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cellsIn vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cells
ChEMBL 953 11 1 14 7.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)CC3CC3)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C 10.1021/jm030418i
44267812 104879 0 None -7 3 Rat 8.8 pKd = 8.8 Binding
In vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cellsIn vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cells
ChEMBL 941 10 1 14 7.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C 10.1021/jm030418i
CHEMBL273440 104879 0 None -7 3 Rat 8.8 pKd = 8.8 Binding
In vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cellsIn vitro binding ability against Luteinizing hormone-releasing hormone release in rat pituitary cells
ChEMBL 941 10 1 14 7.3 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2C(=O)OC[C@@H]2C)[C@H](C)[C@@H](OC2O[C@H](C)C[C@H](N(C)C(C)C)[C@H]2O)[C@@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C 10.1021/jm030418i
CHEMBL412984 219817 0 None - 1 Rat 10.7 pKi = 10.7 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL None None None CC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O 10.1021/jm00130a019
44350635 163992 0 None - 1 Rat 10.6 pKi = 10.6 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1292 32 15 13 0.5 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
CHEMBL407606 163992 0 None - 1 Rat 10.6 pKi = 10.6 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1292 32 15 13 0.5 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
CHEMBL407123 219420 0 None - 1 Rat 10.4 pKi = 10.4 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)NCC(=O)O 10.1021/jm00099a017
44350493 162532 0 None - 1 Rat 10.1 pKi = 10.1 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1296 32 15 14 -0.4 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
CHEMBL405737 162532 0 None - 1 Rat 10.1 pKi = 10.1 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1296 32 15 14 -0.4 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
44350501 148374 0 None - 1 Rat 10.0 pKi = 10.0 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1220 32 14 14 -0.8 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
CHEMBL385042 148374 0 None - 1 Rat 10.0 pKi = 10.0 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1220 32 14 14 -0.8 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
44350636 168726 0 None - 1 Rat 9.8 pKi = 9.8 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1200 33 14 15 -1.9 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
CHEMBL415571 168726 0 None - 1 Rat 9.8 pKi = 9.8 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1200 33 14 15 -1.9 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
44350565 148451 0 None - 1 Rat 9.7 pKi = 9.7 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary Luteinizing Hormone Releasing Hormone (LHRH) receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary Luteinizing Hormone Releasing Hormone (LHRH) receptor binding assay
ChEMBL 1209 32 15 14 -1.4 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
CHEMBL385468 148451 0 None - 1 Rat 9.7 pKi = 9.7 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary Luteinizing Hormone Releasing Hormone (LHRH) receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary Luteinizing Hormone Releasing Hormone (LHRH) receptor binding assay
ChEMBL 1209 32 15 14 -1.4 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
44350487 174018 0 None - 1 Rat 9.7 pKi = 9.7 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1306 32 14 13 0.9 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
CHEMBL429240 174018 0 None - 1 Rat 9.7 pKi = 9.7 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1306 32 14 13 0.9 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
44314940 88890 0 None - 1 Rat 9.6 pKi = 9.6 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1041 26 10 10 2.8 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL216617 88890 0 None - 1 Rat 9.6 pKi = 9.6 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1041 26 10 10 2.8 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
9915237 100298 1 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]hCG from LH receptorDisplacement of [125I]hCG from LH receptor
ChEMBL 539 11 3 6 4.9 CC(C)(C)c1ccc(-n2nc(-c3cccnc3)cc2CCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)cc1 10.1016/j.bmcl.2006.12.062
CHEMBL246321 100298 1 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]hCG from LH receptorDisplacement of [125I]hCG from LH receptor
ChEMBL 539 11 3 6 4.9 CC(C)(C)c1ccc(-n2nc(-c3cccnc3)cc2CCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)cc1 10.1016/j.bmcl.2006.12.062
44350502 175610 0 None - 1 Rat 9.4 pKi = 9.4 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1298 33 14 14 -0.2 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(C)C(C)=O 10.1021/jm00099a017
CHEMBL437798 175610 0 None - 1 Rat 9.4 pKi = 9.4 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1298 33 14 14 -0.2 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(C)C(C)=O 10.1021/jm00099a017
44314937 103637 0 None - 1 Rat 9.3 pKi = 9.3 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1024 25 11 10 1.9 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CC12CC3CC(CC(C3)C1)C2 10.1021/jm00130a019
CHEMBL265413 103637 0 None - 1 Rat 9.3 pKi = 9.3 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1024 25 11 10 1.9 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CC12CC3CC(CC(C3)C1)C2 10.1021/jm00130a019
44315218 105220 0 None - 1 Rat 9.3 pKi = 9.3 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1030 26 11 10 2.1 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL275694 105220 0 None - 1 Rat 9.3 pKi = 9.3 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1030 26 11 10 2.1 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
44314843 103505 0 None - 1 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1106 28 10 10 3.9 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL264298 103505 0 None - 1 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1106 28 10 10 3.9 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
11980076 215232 29 None - 1 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O 10.1021/jm00130a019
36523 215232 29 None - 1 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O 10.1021/jm00130a019
638793 215232 29 None - 1 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O 10.1021/jm00130a019
CHEMBL1007 215232 29 None - 1 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O 10.1021/jm00130a019
CHEMBL1981292 215232 29 None - 1 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O 10.1021/jm00130a019
DB00644 215232 29 None - 1 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O 10.1021/jm00130a019
44315220 168532 0 None - 1 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1044 27 11 10 2.5 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCCc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL413887 168532 0 None - 1 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1044 27 11 10 2.5 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCCc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369787 216466 0 None - 1 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C\c1ccc(OC)cc1 10.1021/jm00130a019
44350492 103727 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary Luteinizing Hormone Releasing Hormone (LHRH) receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary Luteinizing Hormone Releasing Hormone (LHRH) receptor binding assay
ChEMBL 1223 32 14 14 -1.1 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
CHEMBL266205 103727 0 None - 1 Rat 8.9 pKi = 8.9 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary Luteinizing Hormone Releasing Hormone (LHRH) receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary Luteinizing Hormone Releasing Hormone (LHRH) receptor binding assay
ChEMBL 1223 32 14 14 -1.1 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
44314797 174180 0 None - 1 Rat 8.8 pKi = 8.8 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1030 26 11 10 2.1 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL429543 174180 0 None - 1 Rat 8.8 pKi = 8.8 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1030 26 11 10 2.1 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
44314939 168112 0 None - 1 Rat 8.7 pKi = 8.7 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1032 26 11 11 1.5 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)COc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL412573 168112 0 None - 1 Rat 8.7 pKi = 8.7 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1032 26 11 11 1.5 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)COc1cccc2ccccc12 10.1021/jm00130a019
14557596 96141 0 None - 1 Rat 6.9 pKi = 6.9 Binding
In vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 960 27 11 10 1.1 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCCc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369780 96141 0 None - 1 Rat 6.9 pKi = 6.9 Binding
In vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 960 27 11 10 1.1 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCCc1c[nH]c2ccccc12 10.1021/jm00130a019
14557594 96148 0 None - 1 Rat 5.9 pKi = 5.9 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 932 25 11 10 0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369790 96148 0 None - 1 Rat 5.9 pKi = 5.9 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 932 25 11 10 0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
14557629 96156 0 None - 1 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 906 25 10 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1cccnc1 10.1021/jm00130a019
CHEMBL2369809 96156 0 None - 1 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 906 25 10 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1cccnc1 10.1021/jm00130a019
CHEMBL2369793 216468 0 None - 1 Rat 6.8 pKi = 6.8 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1ccc(OC)cc1 10.1021/jm00130a019
14557588 96154 0 None - 1 Rat 7.8 pKi = 7.8 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 980 26 11 10 0.9 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369806 96154 0 None - 1 Rat 7.8 pKi = 7.8 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 980 26 11 10 0.9 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
14557627 96143 0 None - 1 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 908 26 10 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccnc1 10.1021/jm00130a019
CHEMBL2369783 96143 0 None - 1 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 908 26 10 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccnc1 10.1021/jm00130a019
44314897 167239 0 None - 1 Rat 7.7 pKi = 7.7 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1033 28 9 10 3.2 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL411175 167239 0 None - 1 Rat 7.7 pKi = 7.7 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1033 28 9 10 3.2 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
14557582 96144 0 None - 1 Rat 6.7 pKi = 6.7 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 946 26 11 10 0.7 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369784 96144 0 None - 1 Rat 6.7 pKi = 6.7 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 946 26 11 10 0.7 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
44350488 89197 0 None - 1 Rat 8.7 pKi = 8.7 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1219 32 14 13 -0.2 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
CHEMBL217405 89197 0 None - 1 Rat 8.7 pKi = 8.7 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1219 32 14 13 -0.2 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
CHEMBL2369807 216470 0 None - 1 Rat 8.7 pKi = 8.7 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
10418860 105057 0 None - 1 Rat 8.6 pKi = 8.6 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1211 33 14 14 -1.2 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(C)C(C)=O 10.1021/jm00099a017
CHEMBL274682 105057 0 None - 1 Rat 8.6 pKi = 8.6 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1211 33 14 14 -1.2 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN(C)C(C)=O 10.1021/jm00099a017
44315053 105224 0 None - 1 Rat 8.6 pKi = 8.6 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1027 25 10 10 2.4 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL275709 105224 0 None - 1 Rat 8.6 pKi = 8.6 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1027 25 10 10 2.4 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
14557592 96149 0 None - 1 Rat 6.7 pKi = 6.7 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 918 24 11 10 0.4 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369791 96149 0 None - 1 Rat 6.7 pKi = 6.7 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 918 24 11 10 0.4 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00130a019
44314857 168592 0 None - 1 Rat 7.6 pKi = 7.6 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1047 29 9 10 3.6 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL414382 168592 0 None - 1 Rat 7.6 pKi = 7.6 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1047 29 9 10 3.6 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
14557600 96158 0 None - 1 Rat 7.6 pKi = 7.6 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 957 26 10 10 1.4 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369813 96158 0 None - 1 Rat 7.6 pKi = 7.6 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 957 26 10 10 1.4 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
44314845 168674 0 None - 1 Rat 8.5 pKi = 8.5 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1067 28 9 10 3.4 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL415109 168674 0 None - 1 Rat 8.5 pKi = 8.5 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1067 28 9 10 3.4 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369798 216469 0 None - 1 Rat 8.4 pKi = 8.4 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1ccc2ccccc2c1 10.1021/jm00130a019
14557616 96151 0 None - 1 Rat 7.4 pKi = 7.4 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 983 25 10 10 1.9 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369799 96151 0 None - 1 Rat 7.4 pKi = 7.4 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 983 25 10 10 1.9 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
44314846 105048 0 None - 1 Rat 7.4 pKi = 7.4 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1117 28 9 10 4.6 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL274609 105048 0 None - 1 Rat 7.4 pKi = 7.4 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1117 28 9 10 4.6 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369788 216467 0 None - 1 Rat 8.3 pKi = 8.3 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369814 216471 0 None 12 2 Rat 8.3 pKi = 8.3 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
14557590 96155 0 None - 1 Rat 7.4 pKi = 7.4 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 986 26 11 10 1.7 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369808 96155 0 None - 1 Rat 7.4 pKi = 7.4 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 986 26 11 10 1.7 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CCc1c[nH]c2ccccc12 10.1021/jm00130a019
14557620 96157 0 None - 1 Rat 7.3 pKi = 7.3 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 955 25 10 10 1.5 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369810 96157 0 None - 1 Rat 7.3 pKi = 7.3 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 955 25 10 10 1.5 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)/C=C/c1cccc2ccccc12 10.1021/jm00130a019
44314898 148633 0 None - 1 Rat 8.2 pKi = 8.2 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1120 29 10 10 4.3 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL386525 148633 0 None - 1 Rat 8.2 pKi = 8.2 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 1120 29 10 10 4.3 CCNC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](COCc1ccccc1)NC(=O)CCc1cccc2ccccc12 10.1021/jm00130a019
14557608 96146 0 None - 1 Rat 7.2 pKi = 7.2 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 943 25 10 10 1.0 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369789 96146 0 None - 1 Rat 7.2 pKi = 7.2 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 943 25 10 10 1.0 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
14557606 96142 0 None - 1 Rat 6.1 pKi = 6.1 Binding
In vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 929 24 10 10 1.1 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)c1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369781 96142 0 None - 1 Rat 6.1 pKi = 6.1 Binding
In vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity towards Luteinizing hormone receptor from rat pituitary cells is expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 929 24 10 10 1.1 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)c1cccc2ccccc12 10.1021/jm00130a019
14557576 96150 0 None 10 2 Rat 7.1 pKi = 7.1 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 961 26 12 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369794 96150 0 None 10 2 Rat 7.1 pKi = 7.1 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 961 26 12 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
44350486 168560 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1204 32 14 14 -1.3 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
CHEMBL414071 168560 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayNegative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assay
ChEMBL 1204 32 14 14 -1.3 CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 10.1021/jm00099a017
14557614 96153 0 None - 1 Rat 8.0 pKi = 8.0 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 977 25 10 10 1.2 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
CHEMBL2369800 96153 0 None - 1 Rat 8.0 pKi = 8.0 Binding
In vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constantIn vitro binding affinity for Luteinizing hormone releasing hormone receptor from rat pituitary cells, expressed as negative logarithm of the equilibrium dissociation constant
ChEMBL 977 25 10 10 1.2 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 10.1021/jm00130a019
3860 7531 0 None -57 2 Human 8.1 pKd = 8.1 Binding
NoneNone
Drug Central None None None None None
436 7531 0 None -57 2 Human 8.1 pKd = 8.1 Binding
NoneNone
Drug Central None None None None None
50225 7531 0 None -57 2 Human 8.1 pKd = 8.1 Binding
NoneNone
Drug Central None None None None None
CHEMBL2110824 7531 0 None -57 2 Human 8.1 pKd = 8.1 Binding
NoneNone
Drug Central None None None None None
DB06719 7531 0 None -57 2 Human 8.1 pKd = 8.1 Binding
NoneNone
Drug Central None None None None None
1160 8698 0 None - 1 Human 10.9 pKd = 10.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12727981
1160 8698 0 None - 1 Human 10.9 pKd = 10.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1922095
11980076 215232 29 None - 1 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O None
36523 215232 29 None - 1 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O None
638793 215232 29 None - 1 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O None
CHEMBL1007 215232 29 None - 1 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O None
CHEMBL1981292 215232 29 None - 1 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O None
DB00644 215232 29 None - 1 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O None