The four circles depict G protein coupling from GtoPdb and any ranked coupling supported by at least two quantitative datasets.


Receptor names:

No. of supporting datasets (from low to high)
G Protein complexes
○ Gαs ○ Gαi/o ○ Gαq/11 ○ Gα12/13

Class A
(Rhodopsin)




Class A
Orphans

Class B1
(Secretin)

Class B2
(Adhesion)




Class C
(Glutamate)

Class F
(Frizzled)

Class T
(Taste 2)

References

We used the G protein transducer information from the Guide to Pharmacology database (IUPHAR) and the following datasets:

The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY.
Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Sharman, J. L., Campo, B., Cavanagh, D. R., Alexander, S. P. H., Davenport, A. P., Spedding, M., Davies, J. A. & NC-IUPHAR.
Nucleic Acids Res 48, D1006–D1021 (2020). [PMID:31691834]

Illuminating G-Protein-Coupling Selectivity of GPCRs.
Inoue, A., Raimondi, F., Kadji, F. M. N., Singh, G., Kishi, T., Uwamizu, A., Ono, Y., Shinjo, Y., Ishida, S., Arang, N., Kawakami, K., Gutkind, J. S., Aoki, J. & Russell, R. B.
Cell 177, 1933-1947.e25 (2019). [PMID:31160049]

Selectivity Landscape of 100 Therapeutically Relevant GPCR Profiled by an Effector Translocation-Based BRET Platform.
Avet, C., Mancini, A., Breton, B., Gouill, C. L., Hauser, A. S., Normand, C., Kobayashi, H., Gross, F., Hogue, M., Lukasheva, V., Morissette, S., Fauman, E., Fortin, J.-P., Schann, S., Leroy, X., Gloriam, D. E. & Bouvier, M.
bioRxiv 2020.04.20.052027 (2020). doi: 10.1101/2020.04.20.052027