ADRB2 |
β2 |
|
187 |
ECL2 |
N |
E |
glycosylation-site |
4LDL, 6MXT, 4LDE, 3NYA, 7DHI, 6E67, 3PDS, 5D6L, 7XKA, 4GBR, 4QKX, 3NY9, 6OBA, 5X7D, 6PS4, 3P0G, 6PS0, 6PS2, 6PRZ, 3SN6, 5JQH, 3NY8, 6N48, 8JJL, 6PS6, 4LDO, 6PS5, 6PS1, 3KJ6, 5D5B, 5D5A, 7XK9, 6PS3, 7DHR, 2RH1, 3D4S |
ACM2 |
M2 |
|
3 |
N-term |
N |
D |
glycosylation-site |
4MQT, 4MQS, 6OIK, 3UON |
ACM2 |
M2 |
|
6 |
N-term |
N |
D |
glycosylation-site |
4MQT, 4MQS, 7T96, 7T94, 6OIK, 7T90, 7T8X, 3UON |
ACM2 |
M2 |
|
9 |
N-term |
N |
D |
glycosylation-site |
4MQT, 4MQS, 7T96, 7T94, 6OIK, 7T90, 7T8X, 3UON |
5HT1B |
5-HT1B |
3x41 |
138 |
TM3 |
L |
W |
thermostabilising |
4IAR, 5V54, 7C61, 4IAQ |
ACM1 |
M1 |
|
2 |
N-term |
N |
Q |
glycosylation-site |
5CXV, 6OIJ, 6WJC |
ACM1 |
M1 |
|
12 |
N-term |
N |
Q |
glycosylation-site |
5CXV, 6OIJ, 6WJC |
ACM1 |
M1 |
3x37 |
110 |
TM3 |
N |
Q |
glycosylation-site |
5CXV, 6OIJ, 6WJC |
AA2AR |
A2A |
|
154 |
ECL2 |
N |
A |
glycosylation-site |
5OLV, 5OLH, 5N2R, 6GDG, 5IU8, 5OLO, 5G53, 5IUA, 5IU4, 4UHR, 2YDV, 5IU7, 5OM1, 5NLX, 5OM4, 5NM4, 4UG2, 5OLZ, 5NM2, 5MZP, 2YDO, 5IUB, 5OLG, 5MZJ |
NTR1 |
NTS1 |
1x54 |
86 |
TM1 |
A |
L |
thermostabilising |
4GRV, 6Z4S, 4BWB, 6ZA8, 4BUO, 4XES, 6Z4V, 6ZIN, 4BV0, 6YVR, 8FMZ, 6Z66, 7L0P, 6Z4Q, 5T04, 3ZEV, 6Z8N, 8FN0, 7L0Q, 7L0S, 7L0R, 4XEE |
ADRB1 |
β1 |
2x53 |
90 |
TM2 |
M |
V |
thermostabilising |
6H7N, 5F8U, 6H7L, 2YCX, 6H7M, 6TKO, 4GPO, 2YCZ, 2Y02, 4BVN, 3ZPR, 6H7J, 6H7O, 2Y01, 2Y04, 4AMI, 2YCY, 5A8E, 2YCW, 4AMJ, 6IBL, 2Y03, 2Y00, 2VT4, 3ZPQ |
ADRB1 |
β1 |
3x27 |
116 |
TM3 |
C |
L |
receptor-expression |
6H7N, 5F8U, 6H7L, 2YCX, 6H7M, 6TKO, 4GPO, 2YCZ, 2Y02, 4BVN, 3ZPR, 6H7J, 6H7O, 2Y01, 2Y04, 4AMI, 2YCY, 5A8E, 2YCW, 4AMJ, 6IBL, 2Y03, 2Y00, 2VT4, 3ZPQ |
ADRB1 |
β1 |
7x36 |
327 |
TM7 |
F |
A |
thermostabilising |
6H7N, 5F8U, 6H7L, 2YCX, 6H7M, 6TKO, 4GPO, 2YCZ, 2Y02, 4BVN, 3ZPR, 6H7J, 6H7O, 2Y01, 2Y04, 4AMI, 2YCY, 5A8E, 2YCW, 4AMJ, 6IBL, 2Y03, 2Y00, 2VT4, 3ZPQ |
ADRB1 |
β1 |
7x48 |
338 |
TM7 |
F |
M |
thermostabilising |
6H7N, 5F8U, 6H7L, 2YCX, 6H7M, 6TKO, 4GPO, 2YCZ, 2Y02, 4BVN, 3ZPR, 6H7J, 6H7O, 2Y01, 2Y04, 4AMI, 2YCY, 5A8E, 2YCW, 4AMJ, 6IBL, 2Y03, 2Y00, 2VT4, 3ZPQ |
OPRK |
κ |
3x29 |
135 |
TM3 |
I |
L |
receptor-expression |
6VI4, 8DZR, 8DZS, 4DJH, 8DZQ, 8DZP, 7YIT, 6B73 |
OX1R |
OX1 |
6x56 |
319 |
TM6 |
V |
I |
other-effect |
4ZJ8, 6V9S, 4ZJC |
CCR5 |
CCR5 |
4x61 |
163 |
TM4 |
G |
N |
thermostabilising |
7F1R, 7F1T, 6AKY, 6AKX, 7F1Q, 7F1S, 5UIW, 4MBS |
CCR5 |
CCR5 |
1x60 |
58 |
TM1 |
C |
Y |
thermostabilising |
7F1T, 6AKX, 4MBS, 5UIW, 6AKY |
CCR5 |
CCR5 |
6x33 |
233 |
TM6 |
A |
D |
receptor-salt-bridge, thermostabilising |
7F1T, 6AKX, 4MBS, 5UIW, 6AKY |
CCR5 |
CCR5 |
8x49 |
303 |
H8 |
K |
E |
thermostabilising |
7F1T, 6AKX, 4MBS, 5UIW, 6AKY |
GRM5 |
mGlu5 |
5x42 |
742 |
TM5 |
T |
A |
thermostabilising |
5CGC, 7FD9, 4OO9, 7FD8, 7P2L, 5CGD, 6FFH, 6FFI |
GRM5 |
mGlu5 |
5x53 |
753 |
TM5 |
S |
A |
thermostabilising |
5CGC, 7FD9, 4OO9, 7FD8, 7P2L, 5CGD, 6FFH, 6FFI |
GRM5 |
mGlu5 |
1x35 |
579 |
TM1 |
E |
A |
thermostabilising |
5CGC, 4OO9, 7P2L, 5CGD, 6FFH, 6FFI |
GRM5 |
mGlu5 |
3x48 |
667 |
TM3 |
N |
Y |
thermostabilising |
5CGC, 4OO9, 7P2L, 5CGD, 6FFH, 6FFI |
GRM5 |
mGlu5 |
3x50 |
669 |
TM3 |
I |
A |
thermostabilising |
5CGC, 4OO9, 7P2L, 5CGD, 6FFH, 6FFI |
GRM5 |
mGlu5 |
|
675 |
ICL2 |
G |
M |
thermostabilising |
5CGC, 4OO9, 7P2L, 5CGD, 6FFH, 6FFI |
P2Y12 |
P2Y12 |
7x49 |
294 |
TM7 |
D |
N |
receptor-expression, thermostabilising |
4NTJ, 7PP1, 4PXZ, 4PY0 |
AA2AR |
A2A |
2x52 |
54 |
TM2 |
A |
L |
thermostabilising |
5OLV, 5OLH, 5N2R, 5IU8, 5OLO, 5IUA, 5IU4, 3RFM, 4UHR, 2YDV, 5IU7, 5OM1, 5NLX, 5OM4, 3UZC, 5NM4, 4UG2, 5OLZ, 5NM2, 3UZA, 3PWH, 5MZP, 2YDO, 5IUB, 5OLG, 5MZJ, 3REY |
AA2AR |
A2A |
3x36 |
88 |
TM3 |
T |
A |
thermostabilising |
5OLV, 5OLH, 5N2R, 5IU8, 5OLO, 5IUA, 5IU4, 3RFM, 5IU7, 5OM1, 5NLX, 5OM4, 3UZC, 5NM4, 5OLZ, 5NM2, 3UZA, 3PWH, 5MZP, 5IUB, 5OLG, 5MZJ, 3REY |
AA2AR |
A2A |
3x55 |
107 |
TM3 |
R |
A |
thermostabilising |
5OLV, 5OLH, 5N2R, 5IU8, 5OLO, 5IUA, 5IU4, 3RFM, 5IU7, 5OM1, 5NLX, 5OM4, 3UZC, 5NM4, 5OLZ, 5NM2, 3UZA, 3PWH, 5MZP, 5IUB, 5OLG, 5MZJ, 3REY |
AA2AR |
A2A |
4x43 |
122 |
TM4 |
K |
A |
thermostabilising |
5OLV, 5OLH, 5N2R, 5IU8, 5OLO, 5IUA, 5IU4, 3RFM, 5IU7, 5OM1, 5NLX, 5OM4, 3UZC, 5NM4, 5OLZ, 5NM2, 3UZA, 3PWH, 5MZP, 5IUB, 5OLG, 5MZJ, 3REY |
AA2AR |
A2A |
5x63 |
202 |
TM5 |
L |
A |
thermostabilising |
5OLV, 5OLH, 5N2R, 5IU8, 5OLO, 5IUA, 5IU4, 3RFM, 5IU7, 5OM1, 5NLX, 5OM4, 3UZC, 5NM4, 5OLZ, 5NM2, 3UZA, 3PWH, 5MZP, 5IUB, 5OLG, 5MZJ, 3REY |
AA2AR |
A2A |
6x37 |
235 |
TM6 |
L |
A |
thermostabilising |
5OLV, 5OLH, 5N2R, 5IU8, 5OLO, 5IUA, 5IU4, 3RFM, 5IU7, 5OM1, 5NLX, 5OM4, 3UZC, 5NM4, 5OLZ, 5NM2, 3UZA, 3PWH, 5MZP, 5IUB, 5OLG, 5MZJ, 3REY |
AA2AR |
A2A |
6x41 |
239 |
TM6 |
V |
A |
thermostabilising |
5OLV, 5OLH, 5N2R, 5IU8, 5OLO, 5IUA, 5IU4, 3RFM, 5IU7, 5OM1, 5NLX, 5OM4, 3UZC, 5NM4, 5OLZ, 5NM2, 3UZA, 3PWH, 5MZP, 5IUB, 5OLG, 5MZJ, 3REY |
AA2AR |
A2A |
7x41 |
277 |
TM7 |
S |
A |
thermostabilising |
5OLV, 5OLH, 5N2R, 5IU8, 5OLO, 5IUA, 5IU4, 3RFM, 5IU7, 5OM1, 5NLX, 5OM4, 3UZC, 5NM4, 5OLZ, 5NM2, 3UZA, 3PWH, 5MZP, 5IUB, 5OLG, 5MZJ, 3REY |
ADRB1 |
β1 |
1x59 |
68 |
TM1 |
R |
S |
thermostabilising |
6H7N, 5F8U, 6H7L, 2YCX, 6H7M, 4GPO, 2YCZ, 2Y02, 4BVN, 3ZPR, 6H7J, 6H7O, 2Y01, 2Y04, 4AMI, 2YCY, 5A8E, 2YCW, 4AMJ, 6IBL, 2Y03, 2Y00, 2VT4, 3ZPQ |
ADRB1 |
β1 |
5x58 |
227 |
TM5 |
Y |
A |
thermostabilising |
4GPO, 5A8E, 5F8U, 2YCZ, 2YCW, 2Y01, 4AMJ, 2Y04, 2YCX, 2Y03, 3ZPR, 4AMI, 2Y00, 2VT4, 2Y02, 4BVN, 2YCY, 3ZPQ |
ADRB1 |
β1 |
6x27 |
282 |
TM6 |
A |
L |
thermostabilising |
4GPO, 5A8E, 5F8U, 2YCZ, 2YCW, 2Y01, 4AMJ, 2Y04, 2YCX, 2Y03, 3ZPR, 4AMI, 2Y00, 2VT4, 2Y02, 4BVN, 2YCY, 3ZPQ |
ADRB1 |
β1 |
8x59 |
358 |
H8 |
C |
A |
palmitoylation-site |
6H7N, 5F8U, 6H7L, 2YCX, 6H7M, 4GPO, 2YCZ, 2Y02, 4BVN, 3ZPR, 6H7J, 6H7O, 2Y01, 2Y04, 4AMI, 2YCY, 5A8E, 2YCW, 4AMJ, 6IBL, 2Y03, 2Y00, 2VT4, 3ZPQ |
ADRB2 |
β2 |
|
16 |
N-term |
G |
R |
other-effect |
3NY9, 5D5A, 3NY8, 5X7D, 3D4S, 3NYA, 2R4R, 5D6L, 2RH1, 3P0G, 3KJ6, 5D5B |
ADRB2 |
β2 |
1x26 |
27 |
TM1 |
E |
Q |
other-effect |
3NY9, 5D5A, 3NY8, 5X7D, 3D4S, 3NYA, 2R4R, 3PDS, 5D6L, 2RH1, 2R4S, 3P0G, 3KJ6, 5D5B |
5HT2B |
5-HT2B |
3x41 |
144 |
TM3 |
M |
W |
thermostabilising |
6DS0, 5TVN, 4IB4, 6DRY, 6DRX, 5TUD, 6DRZ, 4NC3 |
CCR9 |
CCR9 |
|
34 |
N-term |
T |
E |
glycosylation-site |
5LWE |
CCR9 |
CCR9 |
12x48 |
77 |
ICL1 |
T |
A |
thermostabilising |
5LWE |
CCR9 |
CCR9 |
12x50 |
79 |
ICL1 |
V |
A |
thermostabilising |
5LWE |
CCR9 |
CCR9 |
2x38 |
82 |
TM2 |
M |
A |
thermostabilising |
5LWE |
CCR9 |
CCR9 |
3x47 |
141 |
TM3 |
S |
C |
thermostabilising |
5LWE |
CCR9 |
CCR9 |
5x41 |
216 |
TM5 |
T |
A |
thermostabilising |
5LWE |
CCR9 |
CCR9 |
6x36 |
255 |
TM6 |
V |
A |
thermostabilising |
5LWE |
CCR9 |
CCR9 |
7x29 |
294 |
TM7 |
N |
A |
thermostabilising |
5LWE |
CCR9 |
CCR9 |
7x39 |
304 |
TM7 |
T |
A |
thermostabilising |
5LWE |
CCR9 |
CCR9 |
8x63 |
337 |
H8 |
C |
A |
palmitoylation-site |
5LWE |
FFAR1 |
FFA1 |
2x40 |
42 |
TM2 |
L |
A |
thermostabilising |
5KW2, 5TZY, 5TZR, 4PHU |
FFAR1 |
FFA1 |
3x34 |
88 |
TM3 |
F |
A |
thermostabilising |
5KW2, 5TZR, 4PHU |
FFAR1 |
FFA1 |
3x49 |
103 |
TM3 |
G |
A |
thermostabilising |
5KW2, 5TZY, 5TZR, 4PHU |
FFAR1 |
FFA1 |
5x58 |
202 |
TM5 |
Y |
F |
thermostabilising |
5KW2, 5TZY, 5TZR, 4PHU |
ADRB2 |
β2 |
2x66 |
96 |
TM2 |
M |
T |
receptor-expression |
4LDL, 3SN6, 5JQH, 4LDE, 4LDO, 4GBR, 4QKX |
ADRB2 |
β2 |
23x49 |
98 |
ECL1 |
M |
T |
receptor-expression |
4LDL, 3SN6, 5JQH, 4LDE, 4LDO, 4GBR, 4QKX |
CNR1 |
CB1 |
3x46 |
210 |
TM3 |
T |
A |
thermostabilising |
5XR8, 5TGZ, 5U09, 5XRA |
CRFR1 |
CRF1 |
1x36 |
120 |
TM1 |
V |
A |
thermostabilising |
4K5Y, 8GTG, 8GTI, 8GTM, 4Z9G |
CRFR1 |
CRF1 |
1x60 |
144 |
TM1 |
L |
A |
thermostabilising |
4K5Y, 8GTG, 8GTI, 8GTM, 4Z9G |
CRFR1 |
CRF1 |
2x44 |
156 |
TM2 |
W |
A |
thermostabilising |
4K5Y, 4Z9G |
CRFR1 |
CRF1 |
2x48 |
160 |
TM2 |
S |
A |
thermostabilising |
4K5Y, 4Z9G |
CRFR1 |
CRF1 |
4x43 |
228 |
TM4 |
K |
A |
thermostabilising |
4K5Y, 4Z9G |
CRFR1 |
CRF1 |
45x52 |
260 |
ECL2 |
F |
A |
thermostabilising |
4K5Y, 4Z9G |
CRFR1 |
CRF1 |
5x48 |
277 |
TM5 |
I |
A |
thermostabilising |
4K5Y, 4Z9G |
CRFR1 |
CRF1 |
6x30 |
309 |
TM6 |
Y |
A |
thermostabilising |
4K5Y, 4Z9G |
CRFR1 |
CRF1 |
6x51 |
330 |
TM6 |
F |
A |
thermostabilising |
4K5Y, 4Z9G |
CRFR1 |
CRF1 |
7x38 |
349 |
TM7 |
S |
A |
thermostabilising |
4K5Y, 4Z9G |
CRFR1 |
CRF1 |
7x53 |
363 |
TM7 |
Y |
A |
thermostabilising |
4K5Y, 4Z9G |
GLR |
glucagon |
1x48 |
154 |
TM1 |
G |
A |
thermostabilising |
5EE7 |
GLR |
glucagon |
2x39 |
173 |
TM2 |
R |
A |
thermostabilising |
5YQZ, 5EE7 |
GLR |
glucagon |
2x48 |
182 |
TM2 |
A |
L |
thermostabilising |
5EE7 |
GLR |
glucagon |
2x56 |
190 |
TM2 |
S |
A |
thermostabilising |
5EE7 |
GLR |
glucagon |
2x59 |
193 |
TM2 |
V |
F |
thermostabilising |
5EE7 |
GLR |
glucagon |
|
207 |
ECL1 |
G |
E |
thermostabilising |
5EE7 |
GLR |
glucagon |
3x24 |
223 |
TM3 |
G |
A |
thermostabilising |
5EE7 |
GLR |
glucagon |
4x54 |
276 |
TM4 |
M |
A |
thermostabilising |
5EE7 |
GLR |
glucagon |
6x30 |
344 |
TM6 |
K |
A |
thermostabilising |
5EE7 |
GLR |
glucagon |
6x48 |
362 |
TM6 |
E |
F |
thermostabilising |
5EE7 |
GLR |
glucagon |
7x39 |
387 |
TM7 |
F |
A |
thermostabilising |
5EE7 |
NTR1 |
NTS1 |
3x49 |
166 |
TM3 |
E |
A |
thermostabilising |
4GRV, 4XES |
NTR1 |
NTS1 |
|
215 |
ECL2 |
G |
A |
thermostabilising |
4GRV, 4XEE, 5T04, 4XES |
NTR1 |
NTS1 |
7x43 |
360 |
TM7 |
V |
A |
thermostabilising |
4GRV, 4XEE, 5T04, 4XES |
OPRD |
δ |
|
37 |
N-term |
P |
S |
other-effect |
4N6H |
OPSD |
Rhodopsin |
|
2 |
N-term |
N |
C |
receptor-disulfide-bridge, thermostabilising |
6FKA, 6FKC, 6FK9, 5DYS, 5EN0, 6FKD, 4BEZ, 6FKB, 2X72, 4A4M, 6FK6, 3C9M, 4BEY, 6FK8, 2J4Y, 6FK7 |
OPSD |
Rhodopsin |
2x56 |
90 |
TM2 |
G |
D |
natural-mutation-snp-incl-disease-causing |
4BEZ, 4BEY |
OPSD |
Rhodopsin |
|
282 |
ECL3 |
D |
C |
receptor-disulfide-bridge, thermostabilising |
6FKA, 6FKC, 6FK9, 5DYS, 5EN0, 6FKD, 4BEZ, 6FKB, 2X72, 4A4M, 6FK6, 3C9M, 4BEY, 6FK8, 2J4Y, 6FK7 |
OX2R |
OX2 |
6x39 |
308 |
TM6 |
I |
V |
other-effect |
5WS3, 4S0V, 5WQC |
P2RY1 |
P2Y1 |
7x49 |
320 |
TM7 |
D |
N |
receptor-expression, thermostabilising |
4XNW, 4XNV |
S1PR1 |
S1P1 |
6x30 |
251 |
TM6 |
S |
N |
other-effect |
3V2W, 3V2Y |
S1PR1 |
S1P1 |
6x31 |
252 |
TM6 |
L |
V |
other-effect |
3V2W, 3V2Y |
NPY1R |
Y1 |
3x41 |
129 |
TM3 |
F |
W |
thermostabilising |
5ZBQ, 5ZBH |
PAR2 |
PAR2 |
1x46 |
89 |
TM1 |
G |
A |
thermostabilising |
5NDZ, 5NJ6, 5NDD |
PAR2 |
PAR2 |
2x37 |
108 |
TM2 |
H |
A |
thermostabilising |
5NDZ, 5NJ6, 5NDD |
PAR2 |
PAR2 |
3x34 |
157 |
TM3 |
G |
A |
thermostabilising |
5NDZ, 5NJ6, 5NDD |
PAR2 |
PAR2 |
3x43 |
166 |
TM3 |
M |
L |
thermostabilising |
5NDZ, 5NJ6, 5NDD |
PAR2 |
PAR2 |
3x51 |
174 |
TM3 |
Y |
A |
thermostabilising |
5NDZ, 5NJ6, 5NDD |
PAR2 |
PAR2 |
3x53 |
176 |
TM3 |
V |
E |
thermostabilising |
5NDZ, 5NJ6, 5NDD |
PAR2 |
PAR2 |
|
222 |
ECL2 |
N |
Q |
glycosylation-site |
5NDZ, 5NJ6, 5NDD |
PAR2 |
PAR2 |
5x64 |
268 |
TM5 |
M |
A |
thermostabilising |
5NDZ, 5NJ6, 5NDD |
PAR2 |
PAR2 |
6x38 |
289 |
TM6 |
I |
A |
thermostabilising |
5NDZ, 5NJ6, 5NDD |
PAR2 |
PAR2 |
6x42 |
293 |
TM6 |
L |
A |
thermostabilising |
5NDZ, 5NJ6, 5NDD |
SMO |
SMO |
3x40 |
329 |
TM3 |
V |
F |
receptor-expression, thermostabilising |
5L7I, 5L7D |
ADRB2 |
β2 |
6x27 |
265 |
TM6 |
C |
A |
other-effect |
4LDL, 5JQH, 4LDE, 4LDO, 4QKX |
ACM2 |
M2 |
|
2 |
N-term |
N |
D |
glycosylation-site |
4MQT, 4MQS, 3UON |
ACM2 |
M2 |
|
373 |
ICL3 |
A |
T |
other-effect |
4MQT, 4MQS |
ACM2 |
M2 |
|
374 |
ICL3 |
K |
R |
other-effect |
4MQT, 4MQS |
NTR1 |
NTS1 |
1x51 |
83 |
TM1 |
S |
G |
receptor-expression |
4BV0, 4BWB |
NTR1 |
NTS1 |
2x38 |
101 |
TM2 |
T |
R |
receptor-expression |
4BV0, 4BWB |
NTR1 |
NTS1 |
2x40 |
103 |
TM2 |
H |
D |
receptor-expression |
3ZEV, 4BUO, 4BV0, 4BWB |
NTR1 |
NTS1 |
2x42 |
105 |
TM2 |
H |
Y |
receptor-expression |
3ZEV, 4BUO, 4BV0, 4BWB |
NTR1 |
NTS1 |
2x551 |
119 |
TM2 |
L |
F |
receptor-expression |
4BV0, 4BWB |
NTR1 |
NTS1 |
2x57 |
121 |
TM2 |
M |
L |
receptor-expression |
4BV0, 4BWB |
NTR1 |
NTS1 |
2x60 |
124 |
TM2 |
E |
D |
receptor-expression |
4BV0, 4BWB |
NTR1 |
NTS1 |
2x61 |
125 |
TM2 |
L |
V |
receptor-expression |
4BV0 |
NTR1 |
NTS1 |
3x26 |
143 |
TM3 |
R |
K |
receptor-expression |
4BV0, 4BWB |
NTR1 |
NTS1 |
3x33 |
150 |
TM3 |
D |
E |
receptor-expression |
4BV0, 4BWB |
NTR1 |
NTS1 |
3x44 |
161 |
TM3 |
A |
V |
receptor-expression |
3ZEV, 4BUO, 4BV0, 4BWB |
NTR1 |
NTS1 |
3x50 |
167 |
TM3 |
R |
L |
receptor-expression |
3ZEV, 4BUO, 4BV0, 4BWB |
NTR1 |
NTS1 |
3x55 |
172 |
TM3 |
C |
R |
receptor-expression |
4BV0 |
NTR1 |
NTS1 |
34x53 |
177 |
ICL2 |
A |
H |
receptor-expression |
4BV0 |
NTR1 |
NTS1 |
4x65 |
208 |
TM4 |
M |
V |
receptor-expression |
4BV0 |
NTR1 |
NTS1 |
|
213 |
ECL2 |
R |
L |
receptor-expression |
3ZEV, 4BUO, 4BV0, 4BWB |
NTR1 |
NTS1 |
5x36 |
234 |
TM5 |
V |
L |
receptor-expression |
3ZEV, 4BUO, 4BV0, 4BWB |
NTR1 |
NTS1 |
5x42 |
240 |
TM5 |
V |
L |
receptor-expression |
4BV0, 4BWB |
NTR1 |
NTS1 |
5x54 |
253 |
TM5 |
I |
A |
thermostabilising |
3ZEV, 4BUO, 4BV0, 4BWB |
NTR1 |
NTS1 |
5x63 |
262 |
TM5 |
N |
R |
receptor-expression |
4BV0, 4BWB |
NTR1 |
NTS1 |
5x64 |
263 |
TM5 |
K |
R |
receptor-expression |
4BV0, 4BWB |
NTR1 |
NTS1 |
6x32 |
305 |
TM6 |
H |
R |
receptor-expression |
3ZEV, 4BUO, 4BV0, 4BWB |
NTR1 |
NTS1 |
6x40 |
313 |
TM6 |
V |
M |
receptor-expression |
4BV0 |
NTR1 |
NTS1 |
6x59 |
332 |
TM6 |
C |
V |
receptor-expression |
4BV0, 4BWB |
NTR1 |
NTS1 |
7x25 |
342 |
TM7 |
F |
A |
receptor-expression |
4BV0, 4BWB |
NTR1 |
NTS1 |
7x37 |
354 |
TM7 |
T |
S |
receptor-expression |
4BV0, 4BWB |
NTR1 |
NTS1 |
7x41 |
358 |
TM7 |
F |
V |
receptor-expression |
3ZEV, 4BUO, 4BV0, 4BWB |
NTR1 |
NTS1 |
7x46 |
362 |
TM7 |
S |
A |
receptor-expression |
3ZEV, 4BUO, 4BV0, 4BWB |
OPSD |
Rhodopsin |
|
2 |
N-term |
N |
C |
receptor-disulfide-bridge, other-effect, thermostabilising |
4ZWJ, 5W0P, 5DGY |
OPSD |
Rhodopsin |
3x28 |
113 |
TM3 |
E |
Q |
thermostabilising |
4ZWJ, 5W0P, 5DGY |
OPSD |
Rhodopsin |
6x40 |
257 |
TM6 |
M |
Y |
thermostabilising |
4ZWJ, 5W0P, 5DGY |
OPSD |
Rhodopsin |
|
282 |
ECL3 |
N |
C |
receptor-disulfide-bridge, thermostabilising |
4ZWJ, 5W0P, 5DGY |
AA2AR |
A2A |
|
154 |
ECL2 |
N |
Q |
glycosylation-site |
3VGA, 3VG9 |
OPSD |
Rhodopsin |
2x60 |
94 |
TM2 |
T |
I |
thermostabilising |
5EN0, 5DYS |
AA2AR |
A2A |
2x46 |
48 |
TM2 |
L |
A |
thermostabilising |
2YDO, 4UG2, 2YDV, 4UHR |
AA2AR |
A2A |
2x62 |
65 |
TM2 |
T |
A |
thermostabilising |
2YDO, 4UG2, 2YDV, 4UHR |
AA2AR |
A2A |
3x37 |
89 |
TM3 |
Q |
A |
thermostabilising |
2YDO, 4UG2, 2YDV, 4UHR |
C5AR1 |
C5a1 |
2x53 |
85 |
TM2 |
S |
A |
palmitoylation-site |
5O9H |
C5AR1 |
C5a1 |
2x59 |
91 |
TM2 |
I |
A |
palmitoylation-site |
5O9H |
C5AR1 |
C5a1 |
34x51 |
142 |
ICL2 |
I |
A |
palmitoylation-site |
5O9H |
C5AR1 |
C5a1 |
34x55 |
146 |
ICL2 |
N |
R |
palmitoylation-site |
5O9H |
C5AR1 |
C5a1 |
4x45 |
156 |
TM4 |
A |
L |
palmitoylation-site |
5O9H |
C5AR1 |
C5a1 |
4x62 |
172 |
TM4 |
F |
A |
palmitoylation-site |
5O9H |
C5AR1 |
C5a1 |
5x68 |
232 |
TM5 |
R |
A |
palmitoylation-site |
5O9H |
C5AR1 |
C5a1 |
|
234 |
ICL3 |
A |
E |
palmitoylation-site |
5O9H |
C5AR1 |
C5a1 |
8x54 |
311 |
H8 |
L |
E |
palmitoylation-site |
5O9H |
C5AR1 |
C5a1 |
|
317 |
C-term |
S |
E |
palmitoylation-site |
5O9H |
C5AR1 |
C5a1 |
|
321 |
C-term |
N |
E |
palmitoylation-site |
5O9H |
CXCR4 |
CXCR4 |
3x41 |
125 |
TM3 |
L |
W |
thermostabilising |
4RWS, 3OE0, 3OE8, 3ODU, 3OE9, 3OE6 |
CXCR4 |
CXCR4 |
6x36 |
240 |
TM6 |
T |
P |
thermostabilising |
4RWS, 3OE0, 3OE9 |
DRD3 |
D3 |
3x41 |
119 |
TM3 |
L |
W |
thermostabilising |
3PBL |
NTR1 |
NTS1 |
6x37 |
310 |
TM6 |
L |
A |
thermostabilising |
4GRV |
NTR1 |
NTS1 |
7x41 |
358 |
TM7 |
F |
A |
receptor-expression |
4GRV, 5T04 |
OPSD |
Rhodopsin |
6x40 |
257 |
TM6 |
M |
Y |
thermostabilising |
4A4M |
CXCR4 |
CXCR4 |
45x51 |
187 |
ECL2 |
D |
C |
receptor-ligand-bond, thermostabilising |
4RWS |
AA1R |
A1 |
2x52 |
57 |
TM2 |
A |
L |
thermostabilising |
5N2S |
AA1R |
A1 |
3x36 |
91 |
TM3 |
T |
A |
thermostabilising |
5N2S |
AA1R |
A1 |
|
159 |
ECL2 |
N |
A |
glycosylation-site |
5UEN, 5N2S |
AA1R |
A1 |
5x63 |
205 |
TM5 |
Y |
A |
thermostabilising |
5N2S |
AA1R |
A1 |
6x37 |
236 |
TM6 |
L |
A |
thermostabilising |
5N2S |
AA1R |
A1 |
6x41 |
240 |
TM6 |
L |
A |
thermostabilising |
5N2S |
AA1R |
A1 |
7x41 |
277 |
TM7 |
T |
A |
thermostabilising |
5N2S |
AA1R |
A1 |
8x64 |
309 |
H8 |
C |
S |
palmitoylation-site |
5N2S |
CNR1 |
CB1 |
5x37 |
273 |
TM5 |
E |
K |
receptor-expression, thermostabilising |
5TGZ, 5XR8, 5XRA |
CNR1 |
CB1 |
5x47 |
283 |
TM5 |
T |
V |
receptor-expression |
5TGZ, 5XR8, 5XRA |
CNR1 |
CB1 |
6x32 |
340 |
TM6 |
R |
E |
receptor-expression, thermostabilising |
5TGZ, 5XR8, 5XRA |
ADRB2 |
β2 |
2x63 |
93 |
TM2 |
H |
C |
receptor-ligand-bond, thermostabilising |
3PDS, 4QKX |
NTR1 |
NTS1 |
5x37 |
235 |
TM5 |
K |
R |
receptor-expression |
4BWB |
NTR1 |
NTS1 |
5x61 |
260 |
TM5 |
I |
A |
receptor-expression |
4BWB |
ADRB1 |
β1 |
3x40 |
129 |
TM3 |
I |
V |
thermostabilising |
5A8E, 4BVN |
ADRB1 |
β1 |
3x41 |
130 |
TM3 |
E |
W |
thermostabilising |
5A8E |
ADRB1 |
β1 |
7x53 |
343 |
TM7 |
Y |
L |
thermostabilising |
5A8E, 4BVN |
APJ |
apelin |
3x40 |
117 |
TM3 |
V |
A |
thermostabilising |
5VBL |
APJ |
apelin |
|
177 |
ECL2 |
T |
N |
glycosylation-site |
5VBL |
APJ |
apelin |
6x48 |
261 |
TM6 |
W |
K |
thermostabilising |
5VBL |
APJ |
apelin |
8x59 |
325 |
H8 |
C |
L |
palmitoylation-site |
5VBL |
APJ |
apelin |
8x60 |
326 |
H8 |
C |
M |
palmitoylation-site |
5VBL |
GLP1R |
GLP-1 |
2x56 |
193 |
TM2 |
S |
C |
thermostabilising |
5VEW, 5VEX |
GLP1R |
GLP-1 |
2x59 |
196 |
TM2 |
I |
F |
thermostabilising |
5VEW, 5VEX |
GLP1R |
GLP-1 |
3x24 |
225 |
TM3 |
S |
A |
thermostabilising |
5VEW, 5VEX |
GLP1R |
GLP-1 |
3x32 |
233 |
TM3 |
M |
C |
thermostabilising |
5VEW, 5VEX |
GLP1R |
GLP-1 |
4x48 |
271 |
TM4 |
S |
A |
thermostabilising |
5VEW, 5VEX |
GLP1R |
GLP-1 |
5x51 |
317 |
TM5 |
I |
C |
thermostabilising |
5VEW, 5VEX |
GLP1R |
GLP-1 |
5x52 |
318 |
TM5 |
G |
I |
thermostabilising |
5VEW, 5VEX |
GLP1R |
GLP-1 |
6x30 |
346 |
TM6 |
K |
A |
thermostabilising |
5VEW, 5VEX |
GLP1R |
GLP-1 |
6x31 |
347 |
TM6 |
C |
F |
thermostabilising |
5VEW, 5VEX |
GLP1R |
GLP-1 |
6x45 |
361 |
TM6 |
G |
C |
thermostabilising |
5VEW, 5VEX |
GLP1R |
GLP-1 |
|
207 |
ECL1 |
T |
E |
thermostabilising |
5NX2 |
GLP1R |
GLP-1 |
|
211 |
ECL1 |
Q |
A |
thermostabilising |
5NX2 |
GLP1R |
GLP-1 |
|
215 |
ECL1 |
D |
R |
thermostabilising |
5NX2 |
GLP1R |
GLP-1 |
3x31 |
232 |
TM3 |
L |
F |
thermostabilising |
5NX2 |
GLP1R |
GLP-1 |
|
260 |
ICL2 |
L |
F |
other-effect, thermostabilising |
5NX2 |
GLP1R |
GLP-1 |
|
295 |
ECL2 |
G |
A |
thermostabilising |
5NX2 |
GLP1R |
GLP-1 |
45x52 |
298 |
ECL2 |
T |
A |
thermostabilising |
5NX2 |
GLP1R |
GLP-1 |
5x63 |
329 |
TM5 |
C |
A |
thermostabilising |
5NX2 |
GLP1R |
GLP-1 |
6x42 |
358 |
TM6 |
P |
A |
thermostabilising |
5NX2 |
GLP1R |
GLP-1 |
6x45 |
361 |
TM6 |
G |
A |
thermostabilising |
5NX2 |
GLP1R |
GLP-1 |
6x47 |
363 |
TM6 |
H |
V |
thermostabilising |
5NX2 |
GLP1R |
GLP-1 |
7x56 |
405 |
TM7 |
V |
A |
thermostabilising |
5NX2 |
PTAFR |
PAF |
3x51 |
116 |
TM3 |
F |
Y |
receptor-expression |
5ZKQ, 5ZKP |
PTAFR |
PAF |
|
169 |
ECL2 |
N |
D |
glycosylation-site |
5ZKQ, 5ZKP |
PTAFR |
PAF |
6x34 |
230 |
TM6 |
A |
D |
thermostabilising |
5ZKQ, 5ZKP |
PTAFR |
PAF |
6x38 |
234 |
TM6 |
V |
A |
receptor-expression |
5ZKQ, 5ZKP |
PTAFR |
PAF |
7x49 |
289 |
TM7 |
D |
N |
receptor-expression |
5ZKQ, 5ZKP |
AA2AR |
A2A |
2x50 |
52 |
TM2 |
D |
N |
thermostabilising |
5WF5 |
5HT2C |
5-HT2C |
7x45 |
360 |
TM7 |
C |
N |
receptor-expression, thermostabilising |
6BQG, 6BQH |
DRD2 |
D2 |
3x40 |
122 |
TM3 |
I |
A |
thermostabilising |
6CM4 |
DRD2 |
D2 |
6x37 |
375 |
TM6 |
L |
A |
thermostabilising |
6CM4 |
DRD2 |
D2 |
6x41 |
379 |
TM6 |
L |
A |
thermostabilising |
6CM4 |
Q9WTK1 |
BLT1 |
2x67 |
83 |
TM2 |
H |
G |
thermostabilising |
5X33 |
Q9WTK1 |
BLT1 |
3x21 |
88 |
TM3 |
K |
G |
thermostabilising |
5X33 |
Q9WTK1 |
BLT1 |
5x67 |
212 |
TM5 |
V |
A |
thermostabilising |
5X33 |
Q9WTK1 |
BLT1 |
|
309 |
C-term |
S |
A |
thermostabilising |
5X33 |
EDNRB |
ETB |
1x55 |
124 |
TM1 |
R |
Y |
thermostabilising |
5X93, 5XPR |
EDNRB |
ETB |
5x36 |
270 |
TM5 |
K |
A |
thermostabilising |
5X93, 5XPR |
EDNRB |
ETB |
6x54 |
342 |
TM6 |
S |
A |
thermostabilising |
5X93, 5XPR |
EDNRB |
ETB |
7x48 |
381 |
TM7 |
I |
A |
thermostabilising |
5X93, 5XPR |
EDNRB |
ETB |
8x53 |
396 |
H8 |
C |
A |
palmitoylation-site |
5X93, 5XPR |
EDNRB |
ETB |
8x57 |
400 |
H8 |
C |
A |
palmitoylation-site |
5X93, 5XPR |
EDNRB |
ETB |
|
405 |
C-term |
C |
A |
palmitoylation-site |
5X93, 5XPR |
SMO |
SMO |
|
194 |
N-term |
E |
M |
receptor-expression |
5V56 |
ADRB2 |
β2 |
3x41 |
122 |
TM3 |
E |
W |
receptor-expression, thermostabilising |
3D4S, 3NYA, 3NY9, 3NY8 |
OPSD |
Rhodopsin |
|
18 |
N-term |
V |
I |
other-effect |
2ZIY |
LPAR1 |
LPA1 |
5x37 |
204 |
TM5 |
D |
C |
receptor-disulfide-bridge, thermostabilising |
4Z36 |
LPAR1 |
LPA1 |
6x59 |
282 |
TM6 |
V |
C |
receptor-disulfide-bridge, thermostabilising |
4Z36 |
PAR1 |
PAR1 |
|
250 |
ECL2 |
N |
G |
glycosylation-site |
3VW7 |
PAR1 |
PAR1 |
|
259 |
ECL2 |
N |
S |
glycosylation-site |
3VW7 |
AA2AR |
A2A |
3x39 |
91 |
TM3 |
S |
A |
thermostabilising |
5WF6 |
ADRB1 |
β1 |
7x31 |
322 |
TM7 |
D |
K |
thermostabilising |
4BVN |
EDNRB |
ETB |
2x56 |
154 |
TM2 |
D |
A |
thermostabilising |
5X93 |
OPSD |
Rhodopsin |
|
338 |
C-term |
S |
X |
phosphorylation-site |
5W0P |
OPSD |
Rhodopsin |
3x28 |
113 |
TM3 |
E |
Q |
thermostabilising |
2X72 |