GPCRdb

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

(R)-Ro65-6570	3385	None	0	Human	Binding	pKi	=	-	9.60	1	8	Unclassified	Guide to Pharmacology	383.2	2	1	3	3.87	O=C1NCN(c2ccccc2)C12CCN([C@@H]1Cc3cccc4cccc1c34)CC2	https://pubmed.ncbi.nlm.nih.gov/10476866
(R)-Ro65-6570	3385	None	0	Human	Binding	Ki	=	0.25	9.60	1	8	Displacement of [3H]-orphanin FQ from human OrphaninFQ (hOFQ) receptor	ChEMBL	383.2	2	1	3	3.87	O=C1NCN(c2ccccc2)C12CCN([C@@H]1Cc3cccc4cccc1c34)CC2	https://dx.doi.org/10.1016/s0960-894x(99)00385-6
(R)-Ro65-6570	3385	None	0	Rat	Binding	Ki	=	0.41	9.39	-1	8	Inhibition against binding of radioligand [leucyl-3H]-OFQ to membrane of human embryonic kidney 293 cells overexpressing rat Opioid receptor like 1	ChEMBL	383.2	2	1	3	3.87	O=C1NCN(c2ccccc2)C12CCN([C@@H]1Cc3cccc4cccc1c34)CC2	https://dx.doi.org/10.1016/s0960-894x(00)00111-6
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-bromo)benzamido]morphinan-oxalate	219960	UNDEFINED	0	Human	Binding	pKi	=	10000.00	5.00	-1071519	4	-	PDSP KiDatabase	614.1	4	5	7	2.67	O=C(NC1CCC2(O)C3Cc4ccc(O)c5c4C2(CCN3CC2CC2)C1O5)c1ccc(Br)cc1.O=C(O)C(=O)O	-
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-iodo)benzamido]morphinan-oxalate	219961	UNDEFINED	0	Human	Binding	pKi	=	10000.00	5.00	-2691	4	-	PDSP KiDatabase	662.1	4	5	7	2.52	O=C(NC1CCC2(O)C3Cc4ccc(O)c5c4C2(CCN3CC2CC2)C1O5)c1ccc(I)cc1.O=C(O)C(=O)O	-
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-methyl)benzamido]morphinan-oxalate	219958	UNDEFINED	0	Human	Binding	pKi	=	10000.00	5.00	-245470	4	-	PDSP KiDatabase	550.2	4	5	7	2.22	Cc1ccc(C(=O)NC2CCC3(O)C4Cc5ccc(O)c6c5C3(CCN4CC3CC3)C2O6)cc1.O=C(O)C(=O)O	-
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-t-butyl)benzamido]morphinan-oxalate	219962	UNDEFINED	0	Human	Binding	pKi	=	10000.00	5.00	-2691	4	-	PDSP KiDatabase	592.3	4	5	7	3.21	CC(C)(C)c1ccc(C(=O)NC2CCC3(O)C4Cc5ccc(O)c6c5C3(CCN4CC3CC3)C2O6)cc1.O=C(O)C(=O)O	-
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-trimethylfluoro)benzamido]morphinan-oxalate	219959	UNDEFINED	0	Human	Binding	pKi	=	4.20	8.38	-9	4	-	PDSP KiDatabase	604.2	4	5	7	2.93	O=C(NC1CCC2(O)C3Cc4ccc(O)c5c4C2(CCN3CC2CC2)C1O5)c1ccc(C(F)(F)F)cc1.O=C(O)C(=O)O	-
[(pF)Phe⁴]N/OFQ-(1-13)-NH₂	3073	None	0	Human	Binding	pKi	=	-	11.06	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12070757
[(pF)Phe⁴]N/OFQ-(1-13)-NH₂	3073	None	0	Human	Binding	pKi	=	-	11.06	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/15743186
[Arg¹⁴Lys¹⁵]N/OFQ	467	None	15	Human	Binding	pKi	None	-	9.50	-	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11097863
[Arg¹⁴Lys¹⁵]N/OFQ	467	None	15	Rat	Binding	IC50	=	0.21	9.68	-	2	Displacement of [3H]nociceptin from rat ORL1 receptor expressed in african green monkey COS7 cells by competitive binding assay	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1016/j.bmc.2009.06.015
[Arg¹⁴Lys¹⁵]N/OFQ	467	None	15	Rat	Binding	IC50	=	0.21	9.68	-	2	Displacement of [3H]nociceptin from rat ORL1 receptor expressed in african green monkey COS7 cells	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1016/j.bmc.2008.09.014
[F/G]N/OFQ-(1-13)-NH₂	1636	None	0	Human	Binding	pKi	None	-	9.20	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12967935
[Met]enkephalin	2495	None	37	Guinea pig	Binding	Ki	=	277.00	6.56	-186	8	Displacement of radiolabeled NalBzOH from kappa3 opioid receptor in Hartley guinea pig brain	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1016/j.bmcl.2006.05.060
[Nphe¹]N/OFQ-(1-13)-NH₂	2875	None	0	Human	Binding	pKi	None	-	8.40	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12010780
Ac-RYYRIK-NH₂	268	None	20	Human	Binding	pKi	=	-	8.96	1	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9353393
Ac-RYYRIK-NH₂	268	None	20	Human	Binding	pKi	=	-	8.96	1	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12967935
Ac-RYYRIK-NH₂	268	None	20	Human	Binding	IC50	=	1.04	8.98	1	2	Displacement of [3H]]nociceptin from human ORL1 receptor expressed in African green monkey COS7 cells after 90 mins by topcount analysis	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1016/j.bmc.2014.09.018
Ac-RYYRIK-NH₂	268	None	20	Human	Binding	IC50	=	0.79	9.10	1	2	Displacement of [3H]nociceptin from human ORL1-Galpha fusion receptor in COS7 cells	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1016/j.bmc.2007.11.043

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Ligand source activities (1 row/activity)