Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
44263999 211870 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL 558 15 5 6 3.3 COc1ccc(NC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)O)cc1 10.1021/jm950908d
CHEMBL7753 211870 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL 558 15 5 6 3.3 COc1ccc(NC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)O)cc1 10.1021/jm950908d
CHEMBL267388 217497 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
1022 8450 55 None 4897 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None None 10.1021/jm900592h
443295 8450 55 None 4897 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None None 10.1021/jm900592h
CHEMBL267179 8450 55 None 4897 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None None 10.1021/jm900592h
145952664 169212 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 500 9 3 4 4.6 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4166385 169212 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 500 9 3 4 4.6 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
71698968 97452 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 445 5 1 4 4.2 Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391281 97452 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 445 5 1 4 4.2 Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
44232677 203125 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 408 7 1 7 2.7 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc([N+](=O)[O-])cc3)c2=O)c1 10.1021/jm900592h
CHEMBL562456 203125 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 408 7 1 7 2.7 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc([N+](=O)[O-])cc3)c2=O)c1 10.1021/jm900592h
71698530 97447 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 509 7 1 5 5.3 COc1cccc(Cc2cc(C3CCCCC3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391257 97447 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 509 7 1 5 5.3 COc1cccc(Cc2cc(C3CCCCC3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
44233646 203202 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
CHEMBL562910 203202 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
44233646 203202 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
CHEMBL562910 203202 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
164916035 199129 3 None -16 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5207056 199129 3 None -16 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
71698446 97484 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 427 5 1 5 3.6 COc1ccc(-c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
CHEMBL2391452 97484 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 427 5 1 5 3.6 COc1ccc(-c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
44232924 202102 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551590 202102 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
44232924 202102 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551590 202102 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
122487974 177193 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 497 9 1 5 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4448213 177193 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 497 9 1 5 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O 10.1021/acs.jmedchem.8b01912
168279295 197825 0 None -91 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187135 197825 0 None -91 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
71699142 97481 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 442 6 2 6 3.7 COc1ccc(Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
CHEMBL2391449 97481 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 442 6 2 6 3.7 COc1ccc(Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
71698365 97479 0 None -7 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 484 7 2 7 3.9 COc1ccc(Nc2c(C(C)=O)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
CHEMBL2391447 97479 0 None -7 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 484 7 2 7 3.9 COc1ccc(Nc2c(C(C)=O)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
71699061 97472 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 461 5 1 4 4.7 Cc1cc(Cc2cccc3ccccc23)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391438 97472 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 461 5 1 4 4.7 Cc1cc(Cc2cccc3ccccc23)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
146597625 198041 1 None -47 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 420 5 2 6 3.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5190385 198041 1 None -47 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 420 5 2 6 3.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
168286767 198461 0 None -53 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5196551 198461 0 None -53 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
145949892 169599 0 None -2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4172556 169599 0 None -2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
168279956 197862 0 None -4 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187563 197862 0 None -4 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
168283359 197591 0 None -5 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5183856 197591 0 None -5 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
155519369 177157 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 441 7 1 6 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1OC 10.1021/acs.jmedchem.8b01912
CHEMBL4447830 177157 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 441 7 1 6 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1OC 10.1021/acs.jmedchem.8b01912
44233647 202314 0 None -1 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
CHEMBL554291 202314 0 None -1 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
54580795 68250 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assayAgonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay
ChEMBL 424 8 2 6 4.6 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
CHEMBL1770476 68250 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assayAgonist activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay
ChEMBL 424 8 2 6 4.6 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
44236330 201609 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL539401 201609 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
44236330 201609 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL539401 201609 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
168292800 198841 0 None -3 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5202577 198841 0 None -3 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
155516247 176808 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1ccccc1Cc1cc(C)nn(C(C)C(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4442702 176808 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1ccccc1Cc1cc(C)nn(C(C)C(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL5076914 221248 4 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 expressed in HEK293-A cells assessed as ERK phosphorylation level incubated for 5 mins by ELISA assayAgonist activity at human FPR1 expressed in HEK293-A cells assessed as ERK phosphorylation level incubated for 5 mins by ELISA assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(c2ccccc2)C1=O 10.1016/j.ejmech.2021.113805
168282160 197629 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184490 197629 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
168278342 197930 0 None 1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5188537 197930 0 None 1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
145953127 169218 0 None -9 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 470 8 4 2 4.9 O=C(Nc1ccc(F)cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4166447 169218 0 None -9 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 470 8 4 2 4.9 O=C(Nc1ccc(F)cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL266802 217479 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1ccc(C)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
1022 8450 55 None 4897 3 Human 7.7 pEC50 = 7.7 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None None 10.1021/jm950908d
443295 8450 55 None 4897 3 Human 7.7 pEC50 = 7.7 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None None 10.1021/jm950908d
CHEMBL267179 8450 55 None 4897 3 Human 7.7 pEC50 = 7.7 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None None 10.1021/jm950908d
44233648 201846 0 None -2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL549570 201846 0 None -2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
44233648 201846 0 None -2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL549570 201846 0 None -2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
168280238 197733 0 None -6 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185921 197733 0 None -6 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
155519289 177144 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 427 7 1 6 3.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1OC 10.1021/acs.jmedchem.8b01912
CHEMBL4447632 177144 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 427 7 1 6 3.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1OC 10.1021/acs.jmedchem.8b01912
44232675 202442 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
CHEMBL556485 202442 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
145978177 169840 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 452 8 4 2 4.7 O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4176353 169840 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 452 8 4 2 4.7 O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
168283038 197706 0 None -16 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185462 197706 0 None -16 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
122487986 182753 0 None -1 2 Human 4.6 pEC50 = 4.6 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL4588649 182753 0 None -1 2 Human 4.6 pEC50 = 4.6 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
122181231 128485 0 None -3 3 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL3588871 128485 0 None -3 3 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.ejmech.2017.09.023
44236328 202455 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL556625 202455 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
44236326 202101 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551589 202101 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
44236326 202101 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551589 202101 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
168281748 197664 0 None -6 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184913 197664 0 None -6 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
168283383 197623 0 None -3 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184396 197623 0 None -3 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
44233644 202869 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL560780 202869 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
145952485 169632 0 None -2 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4172968 169632 0 None -2 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
155538591 179184 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 427 7 1 6 3.5 COc1cccc(OC)c1Cc1cc(C)nn(CC(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4476616 179184 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 427 7 1 6 3.5 COc1cccc(OC)c1Cc1cc(C)nn(CC(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
168282231 197741 0 None -16 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185982 197741 0 None -16 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
168291793 198710 0 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5200365 198710 0 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
71699063 97475 0 None -1 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 454 6 2 5 2.6 Cc1cc(Cc2ccc(C(N)=O)cc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391440 97475 0 None -1 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 454 6 2 5 2.6 Cc1cc(Cc2ccc(C(N)=O)cc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL265408 217426 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None CCCCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
71698362 97478 0 None -3 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 455 6 1 6 3.2 COc1cccc(C(=O)c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391446 97478 0 None -3 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 455 6 1 6 3.2 COc1cccc(C(=O)c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL7306 222651 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
24776341 10013 39 None -20 4 Human 7.5 pEC50 = 7.5 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
5831 10013 39 None -20 4 Human 7.5 pEC50 = 7.5 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
CHEMBL379761 10013 39 None -20 4 Human 7.5 pEC50 = 7.5 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
164916036 198366 0 None -147 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5195186 198366 0 None -147 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
44232925 203428 2 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL564392 203428 2 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
44233644 202869 0 None 1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL560780 202869 0 None 1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
44233645 202964 0 None -5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 363 6 1 5 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 10.1021/jm900592h
CHEMBL561375 202964 0 None -5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 363 6 1 5 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 10.1021/jm900592h
44233644 202869 0 None 1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL560780 202869 0 None 1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
44233645 202964 0 None -5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 363 6 1 5 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 10.1021/jm900592h
CHEMBL561375 202964 0 None -5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 363 6 1 5 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 10.1021/jm900592h
168283929 197879 0 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187763 197879 0 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
44236326 202101 0 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551589 202101 0 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
44233647 202314 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
CHEMBL554291 202314 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
44232675 202442 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
CHEMBL556485 202442 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
44233647 202314 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
CHEMBL554291 202314 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
44232675 202442 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
CHEMBL556485 202442 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
44236329 202226 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL552396 202226 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
44236329 202226 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL552396 202226 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL7520 222654 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
11024 7475 19 None -177 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
122583088 7475 19 None -177 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
CHEMBL4784510 7475 19 None -177 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
11024 7475 19 None -177 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acsmedchemlett.2c00079
122583088 7475 19 None -177 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acsmedchemlett.2c00079
CHEMBL4784510 7475 19 None -177 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acsmedchemlett.2c00079
168296342 199226 0 None -2 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5208434 199226 0 None -2 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
71698528 97445 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 503 7 1 5 3.6 CCc1cc(Cc2cccc(OC)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391255 97445 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 503 7 1 5 3.6 CCc1cc(Cc2cccc(OC)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1 10.1016/j.ejmech.2013.03.066
168274924 197048 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
CHEMBL5175543 197048 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
168273654 197105 0 None -6 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5176452 197105 0 None -6 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
122181231 128485 0 None -3 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3588871 128485 0 None -3 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
44233905 203112 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
CHEMBL562380 203112 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
44233905 203112 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
CHEMBL562380 203112 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
168281597 198049 0 None -50 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5190571 198049 0 None -50 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
145956361 168790 0 None 2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4159569 168790 0 None 2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
71698529 97446 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 469 7 1 5 4.4 COc1cccc(Cc2cc(C(C)C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391256 97446 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 469 7 1 5 4.4 COc1cccc(Cc2cc(C(C)C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
71699059 97454 0 None 3 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 417 5 1 5 3.6 Cc1cc(Cc2ccsc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391286 97454 0 None 3 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 417 5 1 5 3.6 Cc1cc(Cc2ccsc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
146597621 198116 0 None -33 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 419 5 2 5 4.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)on2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5191583 198116 0 None -33 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 419 5 2 5 4.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)on2)c(F)c1 10.1021/acsmedchemlett.2c00079
145956762 168947 0 None -1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4162303 168947 0 None -1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
163322252 198659 5 None -26 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5199629 198659 5 None -26 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
457933 222502 28 None -501 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](CCSC)C(N)=O)C(C)C 10.1021/jm900592h
CHEMBL552527 222502 28 None -501 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](CCSC)C(N)=O)C(C)C 10.1021/jm900592h
11024 7475 19 None -12 4 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
122583088 7475 19 None -12 4 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
CHEMBL4784510 7475 19 None -12 4 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR1 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
145958736 168995 0 None -6 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4162930 168995 0 None -6 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
155555898 181146 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4551649 181146 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O 10.1021/acs.jmedchem.8b01912
146035589 180508 0 None -1 2 Human 7.3 pEC50 = 7.3 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 483 10 1 6 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4536334 180508 0 None -1 2 Human 7.3 pEC50 = 7.3 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 483 10 1 6 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
145951856 169670 0 None -8 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4173645 169670 0 None -8 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
71698880 97449 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 411 5 1 4 3.5 Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391277 97449 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 411 5 1 4 3.5 Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
162425412 197847 0 None -21 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 386 5 2 6 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccccc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5187399 197847 0 None -21 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 386 5 2 6 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccccc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
168278240 197880 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187767 197880 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
44233648 201846 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL549570 201846 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
71698972 97453 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 401 5 1 5 3.1 Cc1cc(Cc2ccoc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391285 97453 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 401 5 1 5 3.1 Cc1cc(Cc2ccoc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
145955803 169425 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 488 8 3 3 4.7 Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F 10.1016/j.ejmech.2017.09.023
CHEMBL4169807 169425 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 488 8 3 3 4.7 Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F 10.1016/j.ejmech.2017.09.023
154706263 180348 2 None - 1 Human 8.2 pEC50 = 8.2 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 527 10 1 6 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4532583 180348 2 None - 1 Human 8.2 pEC50 = 8.2 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 527 10 1 6 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
146035588 177675 2 None -5 2 Human 6.2 pEC50 = 6.2 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4454594 177675 2 None -5 2 Human 6.2 pEC50 = 6.2 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
71698527 97444 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 427 6 1 5 3.2 COc1cccc(Cc2ccnn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391254 97444 0 None 1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 427 6 1 5 3.2 COc1cccc(Cc2ccnn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
145956276 169455 0 None 1 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4170201 169455 0 None 1 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
122488043 181045 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 427 7 1 6 3.5 COc1ccc(OC)c(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL4549250 181045 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 427 7 1 6 3.5 COc1ccc(OC)c(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
71698967 97451 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 429 5 1 4 3.7 Cc1cc(Cc2cccc(F)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391280 97451 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 429 5 1 4 3.7 Cc1cc(Cc2cccc(F)c2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
44236328 202455 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL556625 202455 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
44236328 202455 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL556625 202455 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
168269851 196745 0 None -3 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5170711 196745 0 None -3 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
168278228 197859 0 None -3 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187530 197859 0 None -3 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
71698966 97450 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 377 5 1 6 2.5 Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc3c(c2)OCO3)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391279 97450 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 377 5 1 6 2.5 Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc3c(c2)OCO3)n1 10.1016/j.ejmech.2013.03.066
168284664 198292 0 None -7 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 488 5 2 3 4.9 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)Cc2cc(F)ccc21 10.1021/acs.jmedchem.1c02203
CHEMBL5193947 198292 0 None -7 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 488 5 2 3 4.9 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)Cc2cc(F)ccc21 10.1021/acs.jmedchem.1c02203
44236330 201609 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL539401 201609 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
71699065 97476 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 519 7 1 6 3.4 COc1cc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)cc(OC)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391442 97476 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 519 7 1 6 3.4 COc1cc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)cc(OC)c1 10.1016/j.ejmech.2013.03.066
44236329 202226 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL552396 202226 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
44233646 203202 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
CHEMBL562910 203202 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
164916034 198469 0 None -6 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5196771 198469 0 None -6 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
44232925 203428 2 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL564392 203428 2 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
44232925 203428 2 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL564392 203428 2 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR1 in human neutrophiles by chemotaxis assayAgonist activity at FPR1 in human neutrophiles by chemotaxis assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
71699060 97471 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 417 5 1 5 3.6 Cc1cc(Cc2cccs2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391437 97471 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 417 5 1 5 3.6 Cc1cc(Cc2cccs2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
71698442 97480 0 None 3 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 336 3 2 5 1.5 Cc1cc(N)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391448 97480 0 None 3 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 336 3 2 5 1.5 Cc1cc(N)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
145963525 169102 0 None 2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4164673 169102 0 None 2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
146035588 177675 2 None -5 2 Human 6.1 pEC50 = 6.1 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4454594 177675 2 None -5 2 Human 6.1 pEC50 = 6.1 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL6997 222645 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophilsAgonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1cccc(C)c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
71698531 97448 0 None -2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 503 7 1 5 4.9 COc1cccc(Cc2cc(-c3ccccc3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391258 97448 0 None -2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 503 7 1 5 4.9 COc1cccc(Cc2cc(-c3ccccc3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
168272319 197354 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
CHEMBL5180261 197354 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR1 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
71699062 97473 0 None -3 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 412 5 1 5 2.9 Cc1cc(Cc2cccnc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391439 97473 0 None -3 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 412 5 1 5 2.9 Cc1cc(Cc2cccnc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
71699143 97483 0 None -3 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 470 6 2 6 3.2 COc1cccc(C(=O)Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391450 97483 0 None -3 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 470 6 2 6 3.2 COc1cccc(C(=O)Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
145954612 169349 0 None -2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 482 9 4 3 4.8 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4168567 169349 0 None -2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR1 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 482 9 4 3 4.8 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
122181322 128641 0 None -1 3 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590073 128641 0 None -1 3 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR1 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
71699139 97477 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 493 5 1 4 4.0 Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391443 97477 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR1 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 493 5 1 4 4.0 Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1 10.1016/j.ejmech.2013.03.066
44232924 202102 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551590 202102 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
155555363 181153 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 439 8 1 5 4.8 CCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4551842 181153 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 439 8 1 5 4.8 CCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL1628710 63048 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL None None None None 10.1016/j.bmcl.2011.03.049
CHEMBL6450 222633 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
57399909 75061 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 452 6 2 5 4.3 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916276 75061 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 452 6 2 5 4.3 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57398259 75070 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 446 6 2 5 4.4 Cc1nn(-c2ccccc2)c(NS(=O)(=O)C2CCCCC2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
CHEMBL1916286 75070 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 446 6 2 5 4.4 Cc1nn(-c2ccccc2)c(NS(=O)(=O)C2CCCCC2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
57394708 75071 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 459 6 2 6 3.7 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2cccnc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
CHEMBL1916287 75071 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 459 6 2 6 3.7 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2cccnc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
57396213 76346 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 420 6 2 5 4.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934267 76346 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 420 6 2 5 4.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)C)cc1 10.1016/j.bmcl.2011.10.090
57390868 76370 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 448 6 2 6 3.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934423 76370 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 448 6 2 6 3.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOC2)cc1 10.1016/j.bmcl.2011.10.090
54580795 68250 0 None - 1 Human 6.0 pIC50 = 6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 424 8 2 6 4.6 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
CHEMBL1770476 68250 0 None - 1 Human 6.0 pIC50 = 6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 424 8 2 6 4.6 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
54580798 68256 0 None - 1 Human 6.0 pIC50 = 6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 391 7 2 4 5.3 CCC[C@H](NC(=O)c1oc2ccc(OCC)cc2c1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770484 68256 0 None - 1 Human 6.0 pIC50 = 6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 391 7 2 4 5.3 CCC[C@H](NC(=O)c1oc2ccc(OCC)cc2c1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
2528 10472 85 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 10.1016/j.bmcl.2011.03.049
5342 10472 85 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 10.1016/j.bmcl.2011.03.049
5826 10472 85 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 10.1016/j.bmcl.2011.03.049
CHEMBL832 10472 85 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 10.1016/j.bmcl.2011.03.049
DB01138 10472 85 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 10.1016/j.bmcl.2011.03.049
57394598 75025 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 446 7 2 5 3.9 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccccc3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916086 75025 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 446 7 2 5 3.9 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccccc3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57401587 75042 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 6 2 6 2.9 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916257 75042 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 6 2 6 2.9 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57394706 75048 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1cn(-c2ccccc2)nc1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916263 75048 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1cn(-c2ccccc2)nc1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57401680 75049 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 460 8 2 5 4.6 CCC(CC)NC(=O)c1cnn(-c2ccccc2Cl)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916264 75049 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 460 8 2 5 4.6 CCC(CC)NC(=O)c1cnn(-c2ccccc2Cl)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57403415 75053 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 392 8 2 5 3.5 CCC(CC)NC(=O)c1cnn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916268 75053 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 392 8 2 5 3.5 CCC(CC)NC(=O)c1cnn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57397970 76366 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 510 6 2 7 3.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCS(=O)(=O)CC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934419 76366 0 None - 1 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 510 6 2 7 3.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCS(=O)(=O)CC2)cc1 10.1016/j.bmcl.2011.10.090
54586641 68188 0 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 388 5 2 3 4.5 Cc1cccc(C)c1NC(=O)C(c1ccccc1)N(C)C(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770308 68188 0 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 388 5 2 3 4.5 Cc1cccc(C)c1NC(=O)C(c1ccccc1)N(C)C(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
24244526 68244 3 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 327 6 2 5 2.6 CSCCC(NC(=O)c1cnccn1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770469 68244 3 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 327 6 2 5 2.6 CSCCC(NC(=O)c1cnccn1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
54583762 68245 0 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 330 6 2 5 3.1 CSCCC(NC(=O)c1ocnc1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770470 68245 0 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 330 6 2 5 3.1 CSCCC(NC(=O)c1ocnc1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
5126271 68247 1 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 339 6 2 3 4.1 CSCCC(NC(=O)c1ccc(C)cc1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770472 68247 1 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 339 6 2 3 4.1 CSCCC(NC(=O)c1ccc(C)cc1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
54582778 68255 0 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 441 7 2 6 3.5 CCOc1ccc2oc(C(=O)NC(CS(C)(=O)=O)c3nc4ccccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
CHEMBL1770482 68255 0 None - 1 Human 5.0 pIC50 = 5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 441 7 2 6 3.5 CCOc1ccc2oc(C(=O)NC(CS(C)(=O)=O)c3nc4ccccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
155517073 176941 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4444413 176941 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
155529906 178251 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 421 8 3 4 2.8 COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C 10.1039/C9MD00336C
CHEMBL4463562 178251 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 421 8 3 4 2.8 COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C 10.1039/C9MD00336C
57398260 75073 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 526 6 2 5 5.3 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
CHEMBL1916289 75073 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 526 6 2 5 5.3 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
71698276 180578 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 4.1 COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4538076 180578 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 4.1 COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
57398258 75066 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916281 75066 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
3089940 68164 2 None - 1 Human 5.9 pIC50 = 5.9 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 374 5 3 3 4.1 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccccc1 10.1016/j.bmcl.2011.03.049
CHEMBL1770153 68164 2 None - 1 Human 5.9 pIC50 = 5.9 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 374 5 3 3 4.1 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccccc1 10.1016/j.bmcl.2011.03.049
92263206 180952 0 None -1 2 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 465 8 3 5 3.5 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1039/C9MD00336C
CHEMBL4547265 180952 0 None -1 2 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 465 8 3 5 3.5 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1039/C9MD00336C
118707168 119798 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 893 22 6 8 6.6 CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311300 119798 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 893 22 6 8 6.6 CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
155524563 177704 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 435 9 3 4 3.2 COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4455225 177704 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 435 9 3 4 3.2 COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
168286767 198461 0 None -53 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5196551 198461 0 None -53 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
4329947 9279 1 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
5829 9279 1 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
CHEMBL1770297 9279 1 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
57392963 75062 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 466 6 2 5 4.6 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916277 75062 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 466 6 2 5 4.6 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57399910 75065 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 7 2 5 3.8 CCC(C)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916280 75065 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 7 2 5 3.8 CCC(C)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
56949966 76372 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 488 7 2 6 4.4 Cc1nn(C2CCOCC2)c(NS(=O)(=O)c2ccc(C3CC3)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.10.090
CHEMBL1934426 76372 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 488 7 2 6 4.4 Cc1nn(C2CCOCC2)c(NS(=O)(=O)c2ccc(C3CC3)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.10.090
53233899 8193 0 None 69 2 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
5830 8193 0 None 69 2 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770298 8193 0 None 69 2 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
57392872 75024 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 452 6 1 5 4.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916085 75024 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 452 6 1 5 4.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57399908 75047 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1ncn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916262 75047 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1ncn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57399672 76349 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 434 5 2 5 4.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)(C)C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934270 76349 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 434 5 2 5 4.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C(C)(C)C)cc1 10.1016/j.bmcl.2011.10.090
54581781 68183 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 378 5 3 5 2.9 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1cn(C)cn1 10.1016/j.bmcl.2011.03.049
CHEMBL1770301 68183 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 378 5 3 5 2.9 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1cn(C)cn1 10.1016/j.bmcl.2011.03.049
57396467 75050 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 451 8 2 6 3.8 CCC(CC)NC(=O)c1cnn(-c2ccc(C#N)cc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916265 75050 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 451 8 2 6 3.8 CCC(CC)NC(=O)c1cnn(-c2ccc(C#N)cc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL6997 222645 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1cccc(C)c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
117993763 178383 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4465341 178383 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
92263206 180952 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 465 8 3 5 3.5 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1039/C9MD00336C
CHEMBL4547265 180952 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 465 8 3 5 3.5 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1039/C9MD00336C
168281597 198049 0 None -50 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5190571 198049 0 None -50 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
164916036 198366 0 None -147 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5195186 198366 0 None -147 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
71697968 181350 21 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4556626 181350 21 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
155510570 180810 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 449 10 3 4 3.1 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C 10.1039/C9MD00336C
CHEMBL4543372 180810 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 449 10 3 4 3.1 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C 10.1039/C9MD00336C
57401368 76360 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 432 6 2 5 4.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934413 76360 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 432 6 2 5 4.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCC2)cc1 10.1016/j.bmcl.2011.10.090
57399796 75022 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916082 75022 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57401684 75064 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 6 2 5 4.1 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCC(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916279 75064 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 6 2 5 4.1 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCC(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
54581826 68246 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 365 6 2 4 4.5 CSCCC(NC(=O)c1sccc1Cl)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770471 68246 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 365 6 2 4 4.5 CSCCC(NC(=O)c1sccc1Cl)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
57398252 75051 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 427 8 2 6 3.3 CCC(CC)NC(=O)c1cnn(-c2ccccn2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916266 75051 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 427 8 2 6 3.3 CCC(CC)NC(=O)c1cnn(-c2ccccn2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL7486 222653 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None Cc1cccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm950908d
CHEMBL3311030 218117 26 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
10579232 210515 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL 586 14 5 5 3.7 CSCC[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL6779 210515 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL 586 14 5 5 3.7 CSCC[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL415299 219961 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7181 222648 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
168278228 197859 0 None -3 2 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187530 197859 0 None -3 2 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
155517009 176934 0 None 3 2 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4444320 176934 0 None 3 2 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
168279295 197825 0 None -91 2 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187135 197825 0 None -91 2 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
155524563 177704 0 None -1 2 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 435 9 3 4 3.2 COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4455225 177704 0 None -1 2 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 435 9 3 4 3.2 COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
57403416 75069 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 508 6 2 5 5.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C(F)(F)F)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916284 75069 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 508 6 2 5 5.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C(F)(F)F)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
54752118 75072 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 483 6 2 6 4.2 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
CHEMBL1916288 75072 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 483 6 2 6 4.2 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
54752118 75072 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 483 6 2 6 4.2 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.10.090
CHEMBL1916288 75072 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 483 6 2 6 4.2 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.10.090
CHEMBL1770296 215658 33 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL None None None CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2011.03.049
57401370 76363 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 450 8 2 6 3.7 COCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934416 76363 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 450 8 2 6 3.7 COCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
4652862 54291 12 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 331 6 2 3 4.1 CSCCC(NC(=O)C1CCCCC1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1545798 54291 12 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 331 6 2 3 4.1 CSCCC(NC(=O)C1CCCCC1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
54587661 68186 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 386 5 3 3 4.0 O=C(NC(C(=O)NC1CCCCC1)c1ccc(Cl)cc1)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770304 68186 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 386 5 3 3 4.0 O=C(NC(C(=O)NC1CCCCC1)c1ccc(Cl)cc1)c1ccccc1O 10.1016/j.bmcl.2011.03.049
54586640 68187 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 460 5 3 4 4.3 Cc1cccc(C)c1NC(=O)C(NC(=O)c1nc2ccccc2[nH]c1=O)c1ccc(Cl)cc1 10.1016/j.bmcl.2011.03.049
CHEMBL1770307 68187 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 460 5 3 4 4.3 Cc1cccc(C)c1NC(=O)C(NC(=O)c1nc2ccccc2[nH]c1=O)c1ccc(Cl)cc1 10.1016/j.bmcl.2011.03.049
3825824 68248 12 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 415 8 1 4 5.3 CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2011.03.049
CHEMBL1770474 68248 12 None - 1 Human 5.6 pIC50 = 5.6 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 415 8 1 4 5.3 CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccccc1 10.1016/j.bmcl.2011.03.049
57403176 76345 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 406 8 2 5 3.8 CCC(CC)NC(=O)c1c(C)nn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934266 76345 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 406 8 2 5 3.8 CCC(CC)NC(=O)c1c(C)nn(C(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
53233899 8193 0 None -69 2 Mouse 4.6 pIC50 = 4.6 Functional
Antagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
5830 8193 0 None -69 2 Mouse 4.6 pIC50 = 4.6 Functional
Antagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770298 8193 0 None -69 2 Mouse 4.6 pIC50 = 4.6 Functional
Antagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at mouse FPR1 expressed in HEK293 cells assessed as inhibition of fMLFF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
155529906 178251 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 421 8 3 4 2.8 COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C 10.1039/C9MD00336C
CHEMBL4463562 178251 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 421 8 3 4 2.8 COC(=O)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(C)C 10.1039/C9MD00336C
168280238 197733 0 None -6 2 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185921 197733 0 None -6 2 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
155510570 180810 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 449 10 3 4 3.1 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C 10.1039/C9MD00336C
CHEMBL4543372 180810 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 449 10 3 4 3.1 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C 10.1039/C9MD00336C
56949822 76371 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 490 7 2 6 4.6 CO[C@H]1CC[C@@H](n2nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c2NS(=O)(=O)c2ccc(C)cc2)CC1 10.1016/j.bmcl.2011.10.090
CHEMBL1934424 76371 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 490 7 2 6 4.6 CO[C@H]1CC[C@@H](n2nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c2NS(=O)(=O)c2ccc(C)cc2)CC1 10.1016/j.bmcl.2011.10.090
9988173 168695 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL 862 21 7 6 5.5 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL415296 168695 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL 862 21 7 6 5.5 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL266448 217463 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CCCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7214 222649 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
168278342 197930 0 None 1 2 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5188537 197930 0 None 1 2 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
57390867 76362 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 460 6 2 5 5.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCCC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934415 76362 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 460 6 2 5 5.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCCC2)cc1 10.1016/j.bmcl.2011.10.090
117993763 178383 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4465341 178383 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
57392882 75041 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 9 2 5 4.3 CCCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916255 75041 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 9 2 5 4.3 CCCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57394389 76364 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 464 9 2 6 4.1 COCCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934417 76364 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 464 9 2 6 4.1 COCCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
57396150 76369 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 462 6 2 6 3.8 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOCC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934422 76369 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 462 6 2 6 3.8 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCOCC2)cc1 10.1016/j.bmcl.2011.10.090
53233899 8193 0 None 69 2 Human 6.5 pIC50 = 6.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
5830 8193 0 None 69 2 Human 6.5 pIC50 = 6.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770298 8193 0 None 69 2 Human 6.5 pIC50 = 6.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
3939767 68249 3 None - 1 Human 6.5 pIC50 = 6.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 440 8 1 5 5.2 CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccc(C#N)cc1 10.1016/j.bmcl.2011.03.049
CHEMBL1770475 68249 3 None - 1 Human 6.5 pIC50 = 6.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 440 8 1 5 5.2 CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2n1Cc1ccc(C#N)cc1 10.1016/j.bmcl.2011.03.049
4329947 9279 1 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
5829 9279 1 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
CHEMBL1770297 9279 1 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assayAntagonist activity at human FPR1 in expressed in HEK293 cells assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation after 5 mins by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
57398257 75060 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 466 6 1 5 4.7 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916275 75060 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 466 6 1 5 4.7 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N(C)C3CCCCC3)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57392729 76348 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 460 6 2 5 4.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2CC(F)(F)F)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934269 76348 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 460 6 2 5 4.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2CC(F)(F)F)cc1 10.1016/j.bmcl.2011.10.090
57399614 76368 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 543 7 2 6 4.7 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCN(CC(F)(F)F)CC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934421 76368 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 543 7 2 6 4.7 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCN(CC(F)(F)F)CC2)cc1 10.1016/j.bmcl.2011.10.090
54584753 68251 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 424 8 2 6 4.6 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
CHEMBL1770477 68251 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 424 8 2 6 4.6 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
155523344 177520 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 3.7 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1 10.1039/C9MD00336C
CHEMBL4452346 177520 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 in human neutrophils assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 3.7 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1 10.1039/C9MD00336C
168283359 197591 0 None -5 2 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5183856 197591 0 None -5 2 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
164916034 198469 0 None -6 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5196771 198469 0 None -6 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
155517073 176941 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4444413 176941 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
57396149 76365 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 478 6 2 6 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCSCC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934418 76365 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 478 6 2 6 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCSCC2)cc1 10.1016/j.bmcl.2011.10.090
53233899 8193 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
5830 8193 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770298 8193 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
53233899 8193 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
5830 8193 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770298 8193 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated degranulation after 15 mins by fluorescence assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
53233899 8193 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.08.085
5830 8193 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.08.085
CHEMBL1770298 8193 0 None 69 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.08.085
57396214 76350 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 448 8 2 5 4.8 CCC(CC)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934271 76350 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 448 8 2 5 4.8 CCC(CC)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
57392871 75023 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 438 6 2 5 4.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916084 75023 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 438 6 2 5 4.0 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57394609 75046 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 427 8 2 6 3.3 CCC(CC)NC(=O)c1nnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916261 75046 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 427 8 2 6 3.3 CCC(CC)NC(=O)c1nnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
4881668 68189 6 None - 1 Human 5.4 pIC50 = 5.4 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 379 6 2 4 4.8 CSCCC(NC(=O)c1oc2ccccc2c1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770309 68189 6 None - 1 Human 5.4 pIC50 = 5.4 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 379 6 2 4 4.8 CSCCC(NC(=O)c1oc2ccccc2c1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
47012371 68191 5 None - 1 Human 5.4 pIC50 = 5.4 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 329 6 2 4 3.7 CSCCC(NC(=O)c1occc1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770310 68191 5 None - 1 Human 5.4 pIC50 = 5.4 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 329 6 2 4 3.7 CSCCC(NC(=O)c1occc1C)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
54584752 68243 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 341 6 3 4 3.5 CSCCC(NC(=O)c1ccccc1O)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770468 68243 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 341 6 3 4 3.5 CSCCC(NC(=O)c1ccccc1O)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL268823 217547 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)NCC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
168273654 197105 0 None -6 2 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5176452 197105 0 None -6 2 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
102234371 119781 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 889 22 6 8 6.0 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311137 119781 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 889 22 6 8 6.0 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
168283383 197623 0 None -3 2 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184396 197623 0 None -3 2 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR1 transfected in human HL-60 cells assessed as inhibition of fMLF-induced intracellular calcium mobilization preincubated for 10 mins followed by fMLF addition and measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
71697968 181350 21 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4556626 181350 21 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL162488 215589 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)Nc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7122 222647 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7034 222646 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)NC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
4329947 9279 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
5829 9279 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
CHEMBL1770297 9279 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assayAntagonist activity at FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated calcium mobilization by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
4329947 9279 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.08.085
5829 9279 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.08.085
CHEMBL1770297 9279 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.08.085
57401682 75057 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 8 2 5 4.2 CCC(CC)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916272 75057 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 8 2 5 4.2 CCC(CC)NC(=O)c1c(C)nn(-c2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57396468 75068 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916283 75068 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
4329947 9279 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
5829 9279 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
CHEMBL1770297 9279 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
5322194 8646 10 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 376 3 1 5 2.3 CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C 10.1016/j.bmcl.2011.03.049
5827 8646 10 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 376 3 1 5 2.3 CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C 10.1016/j.bmcl.2011.03.049
CHEMBL1770295 8646 10 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 376 3 1 5 2.3 CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C 10.1016/j.bmcl.2011.03.049
57398165 75044 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 412 8 2 5 3.6 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916259 75044 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 412 8 2 5 3.6 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2011.08.085
57398166 75045 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 404 8 2 5 3.5 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)C1CCCC1 10.1016/j.bmcl.2011.08.085
CHEMBL1916260 75045 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 404 8 2 5 3.5 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)C1CCCC1 10.1016/j.bmcl.2011.08.085
57398253 75052 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 9 2 5 4.0 CCC(CC)NC(=O)c1cnn(Cc2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916267 75052 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 440 9 2 5 4.0 CCC(CC)NC(=O)c1cnn(Cc2ccccc2)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.08.085
57398255 75055 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 479 9 2 7 4.2 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916270 75055 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 479 9 2 7 4.2 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1 10.1016/j.bmcl.2011.08.085
57392964 75063 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 6 3.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916278 75063 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 6 3.2 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
54581782 68185 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 380 5 3 3 4.2 O=C(NC(C(=O)Nc1ccccc1)c1ccc(Cl)cc1)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770303 68185 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 380 5 3 3 4.2 O=C(NC(C(=O)Nc1ccccc1)c1ccc(Cl)cc1)c1ccccc1O 10.1016/j.bmcl.2011.03.049
5157579 68242 20 None - 1 Human 5.3 pIC50 = 5.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 325 6 2 3 3.8 CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770466 68242 20 None - 1 Human 5.3 pIC50 = 5.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 325 6 2 3 3.8 CSCCC(NC(=O)c1ccccc1)c1nc2ccccc2[nH]1 10.1016/j.bmcl.2011.03.049
54581827 68252 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 425 8 2 7 4.0 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncncc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
CHEMBL1770478 68252 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 425 8 2 7 4.0 CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4ncncc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
155523344 177520 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 3.7 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1 10.1039/C9MD00336C
CHEMBL4452346 177520 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 3.7 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCC1 10.1039/C9MD00336C
155517009 176934 0 None 3 2 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4444320 176934 0 None 3 2 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL7226 222650 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)NCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7363 222652 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophilsAntagonistic activity was determined by measuring the ability to inhibit superoxide production (stimulated by fMLF) using human neutrophils
ChEMBL None None None CCCCNC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
54580796 68254 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 409 7 2 5 4.9 CCOc1ccc2oc(C(=O)N[C@H](CSC)c3nc4ccccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
CHEMBL1770481 68254 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 409 7 2 5 4.9 CCOc1ccc2oc(C(=O)N[C@H](CSC)c3nc4ccccc4[nH]3)c(C)c2c1 10.1016/j.bmcl.2011.03.049
57391103 75043 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1C 10.1016/j.bmcl.2011.08.085
CHEMBL1916258 75043 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 426 8 2 5 3.9 CCC(CC)NC(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccccc1C 10.1016/j.bmcl.2011.08.085
57398256 75058 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 412 6 2 5 3.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916273 75058 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 412 6 2 5 3.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57401427 76347 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 406 6 2 5 3.5 CCn1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934268 76347 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 406 6 2 5 3.5 CCn1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2011.10.090
54587699 68253 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 391 7 2 4 5.0 CSCCC(NC(=O)c1sccc1Cl)c1ncc(-c2ccccc2)[nH]1 10.1016/j.bmcl.2011.03.049
CHEMBL1770479 68253 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 391 7 2 4 5.0 CSCCC(NC(=O)c1sccc1Cl)c1ncc(-c2ccccc2)[nH]1 10.1016/j.bmcl.2011.03.049
71698276 180578 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 4.1 COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4538076 180578 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR1 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by fMLF addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 475 9 3 4 4.1 COC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
57401681 75056 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 519 8 1 7 5.1 CCN(C(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1)C1CCCCC1 10.1016/j.bmcl.2011.08.085
CHEMBL1916271 75056 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 519 8 1 7 5.1 CCN(C(=O)c1cnn(-c2ccccc2)c1NS(=O)(=O)c1ccc(-c2cnco2)cc1)C1CCCCC1 10.1016/j.bmcl.2011.08.085
57394707 75067 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916282 75067 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57394707 75067 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1916282 75067 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.10.090
57401369 76361 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 446 6 2 5 4.6 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCC2)cc1 10.1016/j.bmcl.2011.10.090
CHEMBL1934414 76361 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assayAntagonist activity at human recombinant FPR1 in expressed in HEK293 cells assessed as inhibition of FMLP-stimulated intracellular calcium mobilisation after 1 hr by FLIPR assay
ChEMBL 446 6 2 5 4.6 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2C2CCCC2)cc1 10.1016/j.bmcl.2011.10.090
54581780 68182 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 402 5 3 3 4.7 Cc1cccc(C(NC(=O)c2ccccc2O)C(=O)Nc2c(C)cccc2C)c1C 10.1016/j.bmcl.2011.03.049
CHEMBL1770300 68182 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 402 5 3 3 4.7 Cc1cccc(C(NC(=O)c2ccccc2O)C(=O)Nc2c(C)cccc2C)c1C 10.1016/j.bmcl.2011.03.049
57399797 75026 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 474 7 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccc(C)cc3C)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916087 75026 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 474 7 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NCc3ccc(C)cc3C)cnn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
57401683 75059 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 452 6 2 5 4.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916274 75059 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assayAntagonist activity at human FPR1 in human neutrophils assessed as inhibition of fMLF-stimulated intracellular calcium mobilisation by FLIPR assay
ChEMBL 452 6 2 5 4.4 Cc1ccc(S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
4654636 68181 9 None - 1 Human 6.1 pIC50 = 6.1 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 408 5 3 3 4.8 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccc(Cl)cc1 10.1016/j.bmcl.2011.03.049
CHEMBL1770299 68181 9 None - 1 Human 6.1 pIC50 = 6.1 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 408 5 3 3 4.8 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)c1ccc(Cl)cc1 10.1016/j.bmcl.2011.03.049
54582743 68184 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 380 5 3 3 4.3 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)C1CCCCC1 10.1016/j.bmcl.2011.03.049
CHEMBL1770302 68184 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Intrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLFIntrinsic activity at FPR1 in human neutrophils assessed as increase in calcium mobilization by FLIPR assay relative to fMLF
ChEMBL 380 5 3 3 4.3 Cc1cccc(C)c1NC(=O)C(NC(=O)c1ccccc1O)C1CCCCC1 10.1016/j.bmcl.2011.03.049
118707023 119775 0 None - 0 Human 7.0 pKd = 7 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 781 20 6 8 4.3 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](COC(C)(C)C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311130 119775 0 None - 0 Human 7.0 pKd = 7 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 781 20 6 8 4.3 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](COC(C)(C)C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311298 218138 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1016/j.bmc.2014.06.048
54752118 75072 0 None - 1 Human 6.9 pKd = 6.9 Functional
Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level
ChEMBL 483 6 2 6 4.2 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
CHEMBL1916288 75072 0 None - 1 Human 6.9 pKd = 6.9 Functional
Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level
ChEMBL 483 6 2 6 4.2 Cc1nn(-c2ccc(F)cc2)c(NS(=O)(=O)c2ccc(C#N)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.08.085
CHEMBL3311144 218128 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311292 218132 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311294 218134 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C(=O)O)[C@@H](C)OC(C)(C)C 10.1016/j.bmc.2014.06.048
118706970 119772 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 795 20 6 8 4.7 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311037 119772 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 795 20 6 8 4.7 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
118707032 119783 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 870 24 7 8 5.1 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)c1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311140 119783 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 870 24 7 8 5.1 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)c1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
118707031 119782 0 None - 0 Human 6.8 pKd = 6.8 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 877 24 7 8 5.3 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)C1CCCCC1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311139 119782 0 None - 0 Human 6.8 pKd = 6.8 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 877 24 7 8 5.3 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)C1CCCCC1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311291 218131 0 None - 0 Human 6.8 pKd = 6.8 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311297 218137 0 None - 0 Human 6.8 pKd = 6.8 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311299 218139 0 None - 0 Human 6.8 pKd = 6.8 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O 10.1016/j.bmc.2014.06.048
102234371 119781 0 None - 1 Human 7.8 pKd = 7.8 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 889 22 6 8 6.0 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311137 119781 0 None - 1 Human 7.8 pKd = 7.8 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 889 22 6 8 6.0 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311031 218118 0 None - 0 Human 6.8 pKd = 6.8 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311293 218133 0 None - 0 Human 6.8 pKd = 6.8 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](COC(C)(C)C)C(=O)O 10.1016/j.bmc.2014.06.048
56949822 76371 0 None - 1 Human 7.7 pKd = 7.7 Functional
Antagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometryAntagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometry
ChEMBL 490 7 2 6 4.6 CO[C@H]1CC[C@@H](n2nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c2NS(=O)(=O)c2ccc(C)cc2)CC1 10.1016/j.bmcl.2011.10.090
CHEMBL1934424 76371 0 None - 1 Human 7.7 pKd = 7.7 Functional
Antagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometryAntagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometry
ChEMBL 490 7 2 6 4.6 CO[C@H]1CC[C@@H](n2nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c2NS(=O)(=O)c2ccc(C)cc2)CC1 10.1016/j.bmcl.2011.10.090
CHEMBL3311134 218124 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
118707168 119798 0 None - 1 Human 8.7 pKd = 8.7 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 893 22 6 8 6.6 CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311300 119798 0 None - 1 Human 8.7 pKd = 8.7 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 893 22 6 8 6.6 CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311036 218123 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311142 218126 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311030 218117 26 None - 1 Human 6.6 pKd = 6.6 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311143 218127 0 None - 0 Human 7.6 pKd = 7.6 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3309281 218115 0 None - 0 Human 6.6 pKd = 6.6 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C(=O)O)C(C)C 10.1016/j.bmc.2014.06.048
CHEMBL3311032 218119 0 None - 0 Human 6.6 pKd = 6.6 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311033 218120 0 None - 0 Human 6.6 pKd = 6.6 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311035 218122 0 None - 0 Human 6.5 pKd = 6.5 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)O 10.1016/j.bmc.2014.06.048
57394707 75067 0 None - 1 Human 6.4 pKd = 6.4 Functional
Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL1916282 75067 0 None - 1 Human 6.4 pKd = 6.4 Functional
Antagonist activity at FPR1 in whole blood assessed as CD11 levelAntagonist activity at FPR1 in whole blood assessed as CD11 level
ChEMBL 454 6 2 5 4.5 Cc1ccc(S(=O)(=O)Nc2c(C(=O)N[C@@H](C)C(C)(C)C)c(C)nn2-c2ccccc2)cc1 10.1016/j.bmcl.2011.08.085
CHEMBL3311034 218121 0 None - 0 Human 6.4 pKd = 6.4 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311289 218130 0 None - 0 Human 6.3 pKd = 6.3 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
118707169 119799 0 None - 0 Human 8.2 pKd = 8.2 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 900 22 6 8 7.3 CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC1CCCCC1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311301 119799 0 None - 0 Human 8.2 pKd = 8.2 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 900 22 6 8 7.3 CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC1CCCCC1)C(=O)O 10.1016/j.bmc.2014.06.048
118707026 119778 0 None - 0 Human 7.2 pKd = 7.2 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 857 21 6 8 5.9 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311133 119778 0 None - 0 Human 7.2 pKd = 7.2 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 857 21 6 8 5.9 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
118707024 119776 0 None - 0 Human 7.2 pKd = 7.2 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 791 20 6 7 5.5 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC1CCCCC1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311131 119776 0 None - 0 Human 7.2 pKd = 7.2 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 791 20 6 7 5.5 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC1CCCCC1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311296 218136 0 None - 0 Human 7.2 pKd = 7.2 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccc(OC(C)(C)C)cc1)C(=O)O 10.1016/j.bmc.2014.06.048
118707029 119780 0 None - 0 Human 7.2 pKd = 7.2 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 925 20 6 10 6.5 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311136 119780 0 None - 0 Human 7.2 pKd = 7.2 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 925 20 6 10 6.5 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311138 218125 0 None - 0 Human 6.1 pKd = 6.1 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
118707025 119777 0 None - 0 Human 7.1 pKd = 7.1 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 819 20 6 7 5.4 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311132 119777 0 None - 0 Human 7.1 pKd = 7.1 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 819 20 6 7 5.4 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311295 218135 0 None - 0 Human 7.1 pKd = 7.1 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC1CCCCC1)C(=O)O 10.1016/j.bmc.2014.06.048
56949966 76372 0 None - 1 Human 6.1 pKd = 6.1 Functional
Antagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometryAntagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometry
ChEMBL 488 7 2 6 4.4 Cc1nn(C2CCOCC2)c(NS(=O)(=O)c2ccc(C3CC3)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.10.090
CHEMBL1934426 76372 0 None - 1 Human 6.1 pKd = 6.1 Functional
Antagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometryAntagonist activity at FPR1 in human neutrophils assessed as AB/fMLF-stimulated upregulation of CD11b expression preincubated for 30 mins before AB/FMLF challenge measured after 50 mins using FITC staining by flow cytometry
ChEMBL 488 7 2 6 4.4 Cc1nn(C2CCOCC2)c(NS(=O)(=O)c2ccc(C3CC3)cc2)c1C(=O)N[C@@H](C)C(C)(C)C 10.1016/j.bmcl.2011.10.090
CHEMBL3311288 218129 0 None - 0 Human 6.1 pKd = 6.1 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)OC(C)(C)C 10.1016/j.bmc.2014.06.048
118707028 119779 0 None - 0 Human 7.1 pKd = 7.1 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 852 21 6 9 4.7 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1cn(C=O)c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
CHEMBL3311135 119779 0 None - 0 Human 7.1 pKd = 7.1 Functional
Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 methodAntagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method
ChEMBL 852 21 6 9 4.7 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1cn(C=O)c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2014.06.048
3092570 6880 12 None - 0 Human 7.0 pKi = 7 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 376 3 0 6 4.1 CCc1cc2c(cc1OC(=O)C)oc(c(c2=O)c1nc2c(n1C)cccc2)C 10.1016/j.bmcl.2011.03.049
5828 6880 12 None - 0 Human 7.0 pKi = 7 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 376 3 0 6 4.1 CCc1cc2c(cc1OC(=O)C)oc(c(c2=O)c1nc2c(n1C)cccc2)C 10.1016/j.bmcl.2011.03.049
CHEMBL1329101 6880 12 None - 0 Human 7.0 pKi = 7 Functional
Antagonist activity at FPR1Antagonist activity at FPR1
ChEMBL 376 3 0 6 4.1 CCc1cc2c(cc1OC(=O)C)oc(c(c2=O)c1nc2c(n1C)cccc2)C 10.1016/j.bmcl.2011.03.049
2831216 47795 15 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 386 3 0 2 4.8 O=C1C(C23CC4CC(CC(C4)C2)C3)C(=O)N(c2ccccc2)N1c1ccccc1 nan
CHEMBL1487404 47795 15 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 386 3 0 2 4.8 O=C1C(C23CC4CC(CC(C4)C2)C3)C(=O)N(c2ccccc2)N1c1ccccc1 nan
5737239 34596 9 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 401 5 1 5 4.0 Cc1ccc(C2C(C(=O)c3ccc(Cl)cc3)=C(O)C(=O)N2CC2CCCO2)o1 nan
CHEMBL1371060 34596 9 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 401 5 1 5 4.0 Cc1ccc(C2C(C(=O)c3ccc(Cl)cc3)=C(O)C(=O)N2CC2CCCO2)o1 nan
658811 51378 8 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 355 3 1 5 4.1 CCC(=O)Nc1c(C#N)c2nc3ccccc3nc2n1-c1ccccc1C nan
CHEMBL1520286 51378 8 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 355 3 1 5 4.1 CCC(=O)Nc1c(C#N)c2nc3ccccc3nc2n1-c1ccccc1C nan
3152750 61413 14 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 349 5 1 5 3.7 O=C(C1=C(O)C(=O)N(Cc2ccccc2)C1c1ccco1)c1ccco1 nan
CHEMBL1611036 61413 14 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 349 5 1 5 3.7 O=C(C1=C(O)C(=O)N(Cc2ccccc2)C1c1ccco1)c1ccco1 nan
4097552 60083 14 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 314 1 1 6 4.0 Cc1ccsc1C1C2=C(O)CC(C)(C)CC2=Nc2ncnn21 nan
CHEMBL1599624 60083 14 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 314 1 1 6 4.0 Cc1ccsc1C1C2=C(O)CC(C)(C)CC2=Nc2ncnn21 nan
5768899 42300 9 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 385 8 1 6 3.2 CCOc1cccc(C(=O)C2=C(O)C(=O)N(CCOC)C2c2ccc(C)o2)c1 nan
CHEMBL1438893 42300 9 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 385 8 1 6 3.2 CCOc1cccc(C(=O)C2=C(O)C(=O)N(CCOC)C2c2ccc(C)o2)c1 nan
655756 47398 13 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 360 5 1 5 3.5 O=C(C1=C(O)C(=O)N(Cc2ccccc2)C1c1ccncc1)c1ccco1 nan
CHEMBL1483985 47398 13 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 360 5 1 5 3.5 O=C(C1=C(O)C(=O)N(Cc2ccccc2)C1c1ccncc1)c1ccco1 nan
2950328 55839 15 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 449 10 1 7 4.2 CCCOc1ccc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2CCCn2ccnc2)cc1 nan
CHEMBL1561325 55839 15 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 449 10 1 7 4.2 CCCOc1ccc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2CCCn2ccnc2)cc1 nan
653420 37200 17 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 299 1 1 4 3.6 Cc1nn2c(O)c3c(nc2c1-c1ccc(Cl)cc1)CCC3 nan
CHEMBL1392442 37200 17 None - 0 Human 4.9 pKi = 4.9 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 299 1 1 4 3.6 Cc1nn2c(O)c3c(nc2c1-c1ccc(Cl)cc1)CCC3 nan
2528 10472 85 None - 1 Human 4.8 pKi = 4.8 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 nan
5342 10472 85 None - 1 Human 4.8 pKi = 4.8 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 nan
5826 10472 85 None - 1 Human 4.8 pKi = 4.8 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 nan
CHEMBL832 10472 85 None - 1 Human 4.8 pKi = 4.8 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 nan
DB01138 10472 85 None - 1 Human 4.8 pKi = 4.8 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 nan
2999882 34044 21 None - 2 Human 4.8 pKi = 4.8 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 341 7 1 5 2.9 COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1ccccc1 nan
CHEMBL1367025 34044 21 None - 2 Human 4.8 pKi = 4.8 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 341 7 1 5 2.9 COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1ccccc1 nan
661728 43677 18 None - 0 Human 4.8 pKi = 4.8 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 419 7 1 5 3.7 COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1ccc(Br)cc1 nan
CHEMBL1450917 43677 18 None - 0 Human 4.8 pKi = 4.8 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 419 7 1 5 3.7 COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1ccc(Br)cc1 nan
3237505 53647 6 None - 1 Human 4.8 pKi = 4.8 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 345 2 2 5 3.2 O=C(NC1CCCC1)c1sc(=S)n2c1[nH]c(=O)c1ccccc12 nan
CHEMBL1540596 53647 6 None - 1 Human 4.8 pKi = 4.8 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 345 2 2 5 3.2 O=C(NC1CCCC1)c1sc(=S)n2c1[nH]c(=O)c1ccccc12 nan
2919194 54619 14 None - 1 Human 4.8 pKi = 4.8 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 404 7 1 6 3.9 CCOc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2Cc2cccnc2)cc1 nan
CHEMBL1548838 54619 14 None - 1 Human 4.8 pKi = 4.8 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 404 7 1 6 3.9 CCOc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2Cc2cccnc2)cc1 nan
2236750 56065 12 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 341 5 1 7 2.5 CCOC(=O)Cc1cc(O)n2nc(C)c(-c3ccc(OC)cc3)c2n1 nan
CHEMBL1563387 56065 12 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 341 5 1 7 2.5 CCOC(=O)Cc1cc(O)n2nc(C)c(-c3ccc(OC)cc3)c2n1 nan
3244340 58966 1 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 382 7 2 4 3.5 CCN(C(=O)Cc1c(C(=O)O)[nH]c2ccccc12)c1cc(OC)ccc1OC nan
CHEMBL1588313 58966 1 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 382 7 2 4 3.5 CCN(C(=O)Cc1c(C(=O)O)[nH]c2ccccc12)c1cc(OC)ccc1OC nan
1078574 39926 12 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 345 4 1 6 3.2 CCOC(=O)Cc1cc(O)n2nc(C)c(-c3ccc(Cl)cc3)c2n1 nan
CHEMBL1417363 39926 12 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 345 4 1 6 3.2 CCOC(=O)Cc1cc(O)n2nc(C)c(-c3ccc(Cl)cc3)c2n1 nan
656027 40230 7 None - 1 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 439 8 1 7 4.2 COc1ccc(CCN2C(=O)C(O)=C(C(=O)c3ccco3)C2c2cccs2)cc1OC nan
CHEMBL1420005 40230 7 None - 1 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 439 8 1 7 4.2 COc1ccc(CCN2C(=O)C(O)=C(C(=O)c3ccco3)C2c2cccs2)cc1OC nan
1300651 51064 17 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 392 5 0 7 4.7 COc1ccccc1Oc1c(C)oc2cc(OC(=O)c3ccco3)ccc2c1=O nan
CHEMBL1517379 51064 17 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 392 5 0 7 4.7 COc1ccccc1Oc1c(C)oc2cc(OC(=O)c3ccco3)ccc2c1=O nan
3240009 50390 2 None - 1 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 333 4 2 5 3.1 CCCCNC(=O)c1sc(=S)n2c1[nH]c(=O)c1ccccc12 nan
CHEMBL1509433 50390 2 None - 1 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 333 4 2 5 3.1 CCCCNC(=O)c1sc(=S)n2c1[nH]c(=O)c1ccccc12 nan
5307697 42634 4 None - 1 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 433 3 0 5 5.2 COc1ccc2ccccc2c1C1CC(=O)N2CN(C3CCCCC3)CSC2=C1C#N nan
CHEMBL1441874 42634 4 None - 1 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 433 3 0 5 5.2 COc1ccc2ccccc2c1C1CC(=O)N2CN(C3CCCCC3)CSC2=C1C#N nan
654635 53787 13 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 433 7 2 6 4.1 COc1cc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2CCc2ccccc2)ccc1O nan
CHEMBL1541719 53787 13 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 433 7 2 6 4.1 COc1cc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2CCc2ccccc2)ccc1O nan
15993744 60407 5 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 353 6 2 5 2.3 COc1ccccc1C1C(C(=O)c2ccccc2)=C(O)C(=O)N1CCO nan
CHEMBL1602770 60407 5 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 353 6 2 5 2.3 COc1ccccc1C1C(C(=O)c2ccccc2)=C(O)C(=O)N1CCO nan
687427 44697 22 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 265 1 1 4 2.9 Cc1nn2c(O)c3c(nc2c1-c1ccccc1)CCC3 nan
CHEMBL1459454 44697 22 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 265 1 1 4 2.9 Cc1nn2c(O)c3c(nc2c1-c1ccccc1)CCC3 nan
1998413 30612 17 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 406 6 0 7 5.1 CCOc1ccccc1Oc1c(C)oc2cc(OC(=O)c3ccco3)ccc2c1=O nan
CHEMBL1336347 30612 17 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 406 6 0 7 5.1 CCOc1ccccc1Oc1c(C)oc2cc(OC(=O)c3ccco3)ccc2c1=O nan
5389675 28713 8 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 468 7 2 8 1.7 COC(=O)c1[nH]c(C)c(C(=O)C2=C(O)C(=O)N(CCN3CCOCC3)C2c2cccnc2)c1C nan
CHEMBL1320528 28713 8 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 468 7 2 8 1.7 COC(=O)c1[nH]c(C)c(C(=O)C2=C(O)C(=O)N(CCN3CCOCC3)C2c2cccnc2)c1C nan
5737165 45518 6 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 411 7 1 6 3.7 CCOc1ccc(C(=O)C2=C(O)C(=O)N(CC3CCCO3)C2c2ccc(C)o2)cc1 nan
CHEMBL1466140 45518 6 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 411 7 1 6 3.7 CCOc1ccc(C(=O)C2=C(O)C(=O)N(CC3CCCO3)C2c2ccc(C)o2)cc1 nan
663185 53358 13 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 379 8 2 7 2.4 O=C(C1=C(O)C(=O)N(CCOCCO)C1c1cccs1)c1cccs1 nan
CHEMBL1538195 53358 13 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 379 8 2 7 2.4 O=C(C1=C(O)C(=O)N(CCOCCO)C1c1cccs1)c1cccs1 nan
651205 26968 20 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 216 1 1 5 1.5 CCc1c(C)nc2c(C#N)c(C)nn2c1O nan
CHEMBL1304907 26968 20 None - 0 Human 4.7 pKi = 4.7 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 216 1 1 5 1.5 CCc1c(C)nc2c(C#N)c(C)nn2c1O nan
3245907 114806 15 None - 1 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 298 2 0 5 2.1 CC(=O)SCC(=O)/N=c1\sc2cc(F)ccc2n1C nan
CHEMBL3194619 114806 15 None - 1 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 298 2 0 5 2.1 CC(=O)SCC(=O)/N=c1\sc2cc(F)ccc2n1C nan
3245336 26463 11 None - 0 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 339 3 1 5 4.1 Cc1cccc(-n2nc3c(c2NC(=O)c2ccco2)CSC3)c1C nan
CHEMBL1300796 26463 11 None - 0 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 339 3 1 5 4.1 Cc1cccc(-n2nc3c(c2NC(=O)c2ccco2)CSC3)c1C nan
5924107 32355 8 None - 0 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 476 7 1 8 3.0 Cc1ccc(C2C(C(=O)c3cnn(-c4ccccc4)c3C)=C(O)C(=O)N2CCN2CCOCC2)o1 nan
CHEMBL1351384 32355 8 None - 0 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 476 7 1 8 3.0 Cc1ccc(C2C(C(=O)c3cnn(-c4ccccc4)c3C)=C(O)C(=O)N2CCN2CCOCC2)o1 nan
658816 26278 8 None - 2 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 321 5 1 5 3.6 CCCCn1c(NC(=O)CC)c(C#N)c2nc3ccccc3nc21 nan
CHEMBL1299357 26278 8 None - 2 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 321 5 1 5 3.6 CCCCn1c(NC(=O)CC)c(C#N)c2nc3ccccc3nc21 nan
15993794 39208 1 None - 0 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 367 6 2 5 2.7 COc1ccccc1C1C(C(=O)c2ccccc2)=C(O)C(=O)N1CC(C)O nan
CHEMBL1411390 39208 1 None - 0 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 367 6 2 5 2.7 COc1ccccc1C1C(C(=O)c2ccccc2)=C(O)C(=O)N1CC(C)O nan
4269075 114283 7 None - 0 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 456 9 1 8 2.6 COc1ccc(OC)c(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCCN2CCOCC2)c1 nan
660781 114283 7 None - 0 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 456 9 1 8 2.6 COc1ccc(OC)c(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCCN2CCOCC2)c1 nan
CHEMBL3185931 114283 7 None - 0 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 456 9 1 8 2.6 COc1ccc(OC)c(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCCN2CCOCC2)c1 nan
2934026 52444 16 None - 0 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 455 8 1 8 4.1 COc1cc(C2C(C(=O)c3cccs3)=C(O)C(=O)N2Cc2ccco2)cc(OC)c1OC nan
CHEMBL1529795 52444 16 None - 0 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 455 8 1 8 4.1 COc1cc(C2C(C(=O)c3cccs3)=C(O)C(=O)N2Cc2ccco2)cc(OC)c1OC nan
754780 51244 12 None - 0 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 264 2 1 5 2.2 Cc1nc2c(C#N)cnn2c(O)c1Cc1ccccc1 nan
CHEMBL1519083 51244 12 None - 0 Human 4.6 pKi = 4.6 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 264 2 1 5 2.2 Cc1nc2c(C#N)cnn2c(O)c1Cc1ccccc1 nan
5766372 31288 6 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 395 7 1 6 3.0 COCCCN1C(=O)C(O)=C(C(=O)c2ccccc2)C1c1ccc2c(c1)OCO2 nan
CHEMBL1342311 31288 6 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 395 7 1 6 3.0 COCCCN1C(=O)C(O)=C(C(=O)c2ccccc2)C1c1ccc2c(c1)OCO2 nan
662399 26540 7 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 417 10 3 8 1.7 COCc1cc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCOCCO)ccc1O nan
CHEMBL1301382 26540 7 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 417 10 3 8 1.7 COCc1cc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCOCCO)ccc1O nan
135406754 30411 10 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 240 6 1 5 2.0 C=CCn1c(SCCCC)nc(O)cc1=O nan
CHEMBL1334790 30411 10 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 240 6 1 5 2.0 C=CCn1c(SCCCC)nc(O)cc1=O nan
649540 52551 10 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 447 8 2 6 4.5 CCOc1cc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2CCc2ccccc2)ccc1O nan
CHEMBL1530728 52551 10 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 447 8 2 6 4.5 CCOc1cc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2CCc2ccccc2)ccc1O nan
655344 73707 6 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 360 5 1 5 3.5 O=C(C1=C(O)C(=O)N(Cc2ccccc2)C1c1cccnc1)c1ccco1 nan
CHEMBL1866204 73707 6 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 360 5 1 5 3.5 O=C(C1=C(O)C(=O)N(Cc2ccccc2)C1c1cccnc1)c1ccco1 nan
2918354 34559 13 None - 1 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 419 7 1 5 3.7 COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1cccc(Br)c1 nan
CHEMBL1370753 34559 13 None - 1 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 419 7 1 5 3.7 COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1cccc(Br)c1 nan
646700 66691 19 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 279 5 1 3 3.0 CCc1ccccc1NC(=O)C(C#N)Cc1cccnc1 nan
CHEMBL1731167 66691 19 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 279 5 1 3 3.0 CCc1ccccc1NC(=O)C(C#N)Cc1cccnc1 nan
5849332 36200 11 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 397 7 1 6 3.4 CCOc1ccc(C(=O)C2=C(O)C(=O)N(CC3CCCO3)C2c2ccco2)cc1 nan
CHEMBL1384171 36200 11 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 397 7 1 6 3.4 CCOc1ccc(C(=O)C2=C(O)C(=O)N(CC3CCCO3)C2c2ccco2)cc1 nan
2947766 196982 9 None - 1 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 486 3 2 7 4.5 COc1cc(-n2nc(C)c3c2OC(N)=C(C#N)C3c2ccccc2)c(Cl)c(Br)c1O nan
CHEMBL517444 196982 9 None - 1 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 486 3 2 7 4.5 COc1cc(-n2nc(C)c3c2OC(N)=C(C#N)C3c2ccccc2)c(Cl)c(Br)c1O nan
5308660 29045 12 None - 1 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 467 8 1 7 4.6 COc1ccc(-n2c(Cc3cccn3C)nnc2SCC(=O)Nc2ccc(Cl)cc2)cc1 nan
CHEMBL1323550 29045 12 None - 1 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 467 8 1 7 4.6 COc1ccc(-n2c(Cc3cccn3C)nnc2SCC(=O)Nc2ccc(Cl)cc2)cc1 nan
5809588 52030 7 None - 0 Human 5.5 pKi = 5.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 419 7 1 6 4.1 COc1ccc(OC)c(C2C(C(=O)c3ccccc3)=C(O)C(=O)N2Cc2ccco2)c1 nan
CHEMBL1526212 52030 7 None - 0 Human 5.5 pKi = 5.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 419 7 1 6 4.1 COc1ccc(OC)c(C2C(C(=O)c3ccccc3)=C(O)C(=O)N2Cc2ccco2)c1 nan
3239469 27534 8 None - 1 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 463 6 2 8 3.7 O=C(O)CCCNc1cc(N2CCC3(CC2)OCCO3)c2noc3c2c1C(=O)c1ccccc1-3 nan
CHEMBL1309430 27534 8 None - 1 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 463 6 2 8 3.7 O=C(O)CCCNc1cc(N2CCC3(CC2)OCCO3)c2noc3c2c1C(=O)c1ccccc1-3 nan
2934282 29494 20 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 365 5 1 5 4.1 O=C(C1=C(O)C(=O)N(Cc2ccco2)C1c1ccccc1)c1cccs1 nan
CHEMBL1327566 29494 20 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 365 5 1 5 4.1 O=C(C1=C(O)C(=O)N(Cc2ccco2)C1c1ccccc1)c1cccs1 nan
135522128 38689 7 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 359 6 2 6 3.2 CCC(Sc1nc(O)c2c(n1)CCC2)C(=O)Nc1cccc(OC)c1 nan
CHEMBL1407375 38689 7 None - 0 Human 4.5 pKi = 4.5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 359 6 2 6 3.2 CCC(Sc1nc(O)c2c(n1)CCC2)C(=O)Nc1cccc(OC)c1 nan
3241118 87063 7 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 363 4 1 3 3.6 O=C(NCc1cccnc1)C1c2ccccc2C(=O)N1C1CCCCCC1 nan
CHEMBL2140184 87063 7 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 363 4 1 3 3.6 O=C(NCc1cccnc1)C1c2ccccc2C(=O)N1C1CCCCCC1 nan
661828 58896 14 None - 3 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 460 6 1 8 4.5 COc1ccc(OC)c(C2C(C(=O)c3cc4ccccc4o3)=C(O)C(=O)N2c2cc(C)on2)c1 nan
CHEMBL1587683 58896 14 None - 3 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 460 6 1 8 4.5 COc1ccc(OC)c(C2C(C(=O)c3cc4ccccc4o3)=C(O)C(=O)N2c2cc(C)on2)c1 nan
654182 51533 16 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 311 4 1 6 2.5 CCOC(=O)Cc1cc(O)n2nc(C)c(-c3ccccc3)c2n1 nan
CHEMBL1521564 51533 16 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 311 4 1 6 2.5 CCOC(=O)Cc1cc(O)n2nc(C)c(-c3ccccc3)c2n1 nan
652107 53464 13 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 433 8 1 6 4.1 COc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCc2ccccc2)cc1OC nan
CHEMBL1539091 53464 13 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 433 8 1 6 4.1 COc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCc2ccccc2)cc1OC nan
3243503 47857 2 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 454 4 1 5 3.6 Cc1c(C(=O)NC2CCCc3ccccc32)oc2ccc(S(=O)(=O)N3CCOCC3)cc12 nan
CHEMBL1487874 47857 2 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 454 4 1 5 3.6 Cc1c(C(=O)NC2CCCc3ccccc32)oc2ccc(S(=O)(=O)N3CCOCC3)cc12 nan
3244947 52450 3 None - 2 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 478 6 1 7 4.6 CCC(SC1=Nc2ccccc2C2=NC(CC(C)C)C(=O)N12)C(=O)Nc1ccc2c(c1)OCO2 nan
CHEMBL1529812 52450 3 None - 2 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 478 6 1 7 4.6 CCC(SC1=Nc2ccccc2C2=NC(CC(C)C)C(=O)N12)C(=O)Nc1ccc2c(c1)OCO2 nan
15993796 60522 1 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 397 7 2 6 2.7 COc1ccc(C2C(C(=O)c3ccccc3)=C(O)C(=O)N2CC(C)O)c(OC)c1 nan
CHEMBL1603724 60522 1 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 397 7 2 6 2.7 COc1ccc(C2C(C(=O)c3ccccc3)=C(O)C(=O)N2CC(C)O)c(OC)c1 nan
2911882 40745 14 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 439 7 1 8 4.3 C=CCOc1ccc(C2C(C(=O)c3cccs3)=C(O)C(=O)N2c2nnc(C)s2)cc1 nan
CHEMBL1424261 40745 14 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 439 7 1 8 4.3 C=CCOc1ccc(C2C(C(=O)c3cccs3)=C(O)C(=O)N2c2nnc(C)s2)cc1 nan
3238730 30281 6 None - 1 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 359 2 2 5 3.6 O=C(NC1CCCCC1)c1sc(=S)n2c1[nH]c(=O)c1ccccc12 nan
CHEMBL1333773 30281 6 None - 1 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 359 2 2 5 3.6 O=C(NC1CCCCC1)c1sc(=S)n2c1[nH]c(=O)c1ccccc12 nan
3245487 49470 4 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 474 8 3 7 3.4 CCCCCNC(=O)c1ccc2c(=O)[nH]c3c(C(=O)NCC4CCCO4)sc(=S)n3c2c1 nan
CHEMBL1501475 49470 4 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 474 8 3 7 3.4 CCCCCNC(=O)c1ccc2c(=O)[nH]c3c(C(=O)NCC4CCCO4)sc(=S)n3c2c1 nan
3242491 67042 7 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 377 4 1 3 4.0 O=C(NCc1cccnc1)C1c2ccccc2C(=O)N1C1CCCCCCC1 nan
CHEMBL1741640 67042 7 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 377 4 1 3 4.0 O=C(NCc1cccnc1)C1c2ccccc2C(=O)N1C1CCCCCCC1 nan
4523283 43984 8 None - 1 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 442 5 3 4 4.9 Cc1sc(NC(=O)C2CCCCC2C(=O)O)c(C(N)=O)c1-c1ccc(C(C)(C)C)cc1 nan
CHEMBL1453327 43984 8 None - 1 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 442 5 3 4 4.9 Cc1sc(NC(=O)C2CCCCC2C(=O)O)c(C(N)=O)c1-c1ccc(C(C)(C)C)cc1 nan
3242292 56764 8 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 433 7 2 7 2.6 CC(C)OC(=O)c1cc(NC(=O)C2C3CCC(O3)C2C(=O)O)cc(C(=O)OC(C)C)c1 nan
CHEMBL1569039 56764 8 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 433 7 2 7 2.6 CC(C)OC(=O)c1cc(NC(=O)C2C3CCC(O3)C2C(=O)O)cc(C(=O)OC(C)C)c1 nan
2949891 29001 14 None - 1 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 432 8 1 6 4.6 CCCOc1ccc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2Cc2cccnc2)cc1 nan
5034814 29001 14 None - 1 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 432 8 1 6 4.6 CCCOc1ccc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2Cc2cccnc2)cc1 nan
CHEMBL1323117 29001 14 None - 1 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 432 8 1 6 4.6 CCCOc1ccc(C2C(C(=O)c3ccc(C)o3)=C(O)C(=O)N2Cc2cccnc2)cc1 nan
5814637 58642 7 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 447 7 1 7 3.9 COC(=O)c1ccc(C2C(C(=O)c3ccc(OC)cc3)=C(O)C(=O)N2Cc2ccco2)cc1 nan
CHEMBL1585547 58642 7 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 447 7 1 7 3.9 COC(=O)c1ccc(C2C(C(=O)c3ccc(OC)cc3)=C(O)C(=O)N2Cc2ccco2)cc1 nan
714146 28068 13 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 230 3 1 3 4.1 Cc1ccc(Nc2nc(C3CC3)cs2)cc1 nan
CHEMBL1313648 28068 13 None - 0 Human 4.4 pKi = 4.4 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 230 3 1 3 4.1 Cc1ccc(Nc2nc(C3CC3)cs2)cc1 nan
658861 27955 8 None - 1 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 307 4 1 5 3.2 CCCCn1c(NC(C)=O)c(C#N)c2nc3ccccc3nc21 nan
CHEMBL1312768 27955 8 None - 1 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 307 4 1 5 3.2 CCCCn1c(NC(C)=O)c(C#N)c2nc3ccccc3nc21 nan
665729 27282 11 None - 0 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 474 5 2 8 3.8 COc1cc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2c2cc(C)on2)cc(Br)c1O nan
CHEMBL1307438 27282 11 None - 0 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 474 5 2 8 3.8 COc1cc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2c2cc(C)on2)cc(Br)c1O nan
3239535 34061 7 None - 0 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 367 1 3 6 4.6 Cc1ccc(C2C3=C(O)CC(C)(C)CC3=Nc3nc(S)nc(O)c32)cc1 nan
CHEMBL1367155 34061 7 None - 0 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 367 1 3 6 4.6 Cc1ccc(C2C3=C(O)CC(C)(C)CC3=Nc3nc(S)nc(O)c32)cc1 nan
666948 60958 11 None - 0 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 316 4 1 6 2.6 COc1ccc(OC)c(C(=O)c2nc3c(n2O)CCCCC3)c1 nan
CHEMBL1607212 60958 11 None - 0 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 316 4 1 6 2.6 COc1ccc(OC)c(C(=O)c2nc3c(n2O)CCCCC3)c1 nan
3243635 114503 1 None - 0 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 401 5 1 5 3.4 CCC(CC)C(=O)/N=c1\c2cnn(-c3ccccc3)c2[nH]c(=O)n1-c1ccccc1 nan
CHEMBL3191155 114503 1 None - 0 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 401 5 1 5 3.4 CCC(CC)C(=O)/N=c1\c2cnn(-c3ccccc3)c2[nH]c(=O)n1-c1ccccc1 nan
5389834 30947 4 None - 0 Human 5.3 pKi = 5.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 473 7 2 8 2.4 COC(=O)c1[nH]c(C)c(C(=O)C2=C(O)C(=O)N(CCN3CCOCC3)C2c2cccs2)c1C nan
CHEMBL1339330 30947 4 None - 0 Human 5.3 pKi = 5.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 473 7 2 8 2.4 COC(=O)c1[nH]c(C)c(C(=O)C2=C(O)C(=O)N(CCN3CCOCC3)C2c2cccs2)c1C nan
754782 53375 11 None - 0 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 278 2 1 5 2.5 Cc1nc2c(C#N)c(C)nn2c(O)c1Cc1ccccc1 nan
CHEMBL1538337 53375 11 None - 0 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 278 2 1 5 2.5 Cc1nc2c(C#N)c(C)nn2c(O)c1Cc1ccccc1 nan
1043390 56696 7 None - 1 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 383 5 1 10 1.4 CC(C)OC(=O)c1nnn(-c2nonc2N)c1CN1CCc2ccccc2C1 nan
CHEMBL1568452 56696 7 None - 1 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 383 5 1 10 1.4 CC(C)OC(=O)c1nnn(-c2nonc2N)c1CN1CCc2ccccc2C1 nan
4781 11112 98 None 67 2 Human 5.3 pKi = 5.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 308 5 0 2 3.8 CCCCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O nan
CHEMBL101 11112 98 None 67 2 Human 5.3 pKi = 5.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 308 5 0 2 3.8 CCCCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O nan
870377 34214 8 None - 2 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 315 1 1 4 4.1 Cc1nn2c(O)c3c(nc2c1-c1cccc2ccccc12)CCC3 nan
CHEMBL1368337 34214 8 None - 2 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 315 1 1 4 4.1 Cc1nn2c(O)c3c(nc2c1-c1cccc2ccccc12)CCC3 nan
646794 53047 5 None - 2 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 354 5 1 6 2.4 O=C(C1=C(O)C(=O)N(CC2CCCO2)C1c1cccnc1)c1ccco1 nan
CHEMBL1535358 53047 5 None - 2 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 354 5 1 6 2.4 O=C(C1=C(O)C(=O)N(CC2CCCO2)C1c1cccnc1)c1ccco1 nan
5992808 46632 0 None - 0 Human 5.3 pKi = 5.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 365 6 1 4 3.9 COc1ccccc1C1C(C(=O)c2ccccc2)=C(O)C(=O)N1CC(C)C nan
CHEMBL1477329 46632 0 None - 0 Human 5.3 pKi = 5.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 365 6 1 4 3.9 COc1ccccc1C1C(C(=O)c2ccccc2)=C(O)C(=O)N1CC(C)C nan
2918125 53262 11 None - 1 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 419 8 1 6 4.3 COCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1cccc(Oc2ccccc2)c1 nan
CHEMBL1537448 53262 11 None - 1 Human 4.3 pKi = 4.3 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 419 8 1 6 4.3 COCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1cccc(Oc2ccccc2)c1 nan
2919487 66481 15 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 437 9 1 7 4.0 CCOc1ccc(C2C(C(=O)c3cccs3)=C(O)C(=O)N2CCCn2ccnc2)cc1 nan
CHEMBL1723342 66481 15 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 437 9 1 7 4.0 CCOc1ccc(C2C(C(=O)c3cccs3)=C(O)C(=O)N2CCCn2ccnc2)cc1 nan
5389956 36819 6 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 489 8 2 8 3.6 COc1cc(C2C(C(=O)c3ccc4c(c3)CC(C)O4)=C(O)C(=O)N2CCCn2ccnc2)ccc1O nan
CHEMBL1389122 36819 6 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 489 8 2 8 3.6 COc1cc(C2C(C(=O)c3ccc4c(c3)CC(C)O4)=C(O)C(=O)N2CCCn2ccnc2)ccc1O nan
6052305 48901 10 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 424 6 1 7 4.5 CCOc1ccc(C(=O)C2=C(O)C(=O)N(c3nc(C)c(C)s3)C2c2ccco2)cc1 nan
CHEMBL1496459 48901 10 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 424 6 1 7 4.5 CCOc1ccc(C(=O)C2=C(O)C(=O)N(c3nc(C)c(C)s3)C2c2ccco2)cc1 nan
661937 55939 9 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 447 7 1 7 3.1 O=C(C1=C(O)C(=O)N(CCCN2CCOCC2)C1c1ccccn1)c1cc2ccccc2o1 nan
CHEMBL1562262 55939 9 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 447 7 1 7 3.1 O=C(C1=C(O)C(=O)N(CCCN2CCOCC2)C1c1ccccn1)c1cc2ccccc2o1 nan
646278 26757 5 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 440 7 2 9 4.0 CCc1nnc(NC(=O)CSc2nnc(-c3cc4ccccc4cc3O)n2CC)s1 nan
CHEMBL1303183 26757 5 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 440 7 2 9 4.0 CCc1nnc(NC(=O)CSc2nnc(-c3cc4ccccc4cc3O)n2CC)s1 nan
3243318 27487 6 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 481 9 2 8 3.7 COc1ccccc1-n1c(CNC(=O)c2ccco2)nnc1SCC(=O)Nc1ccc(F)cc1 nan
CHEMBL1309064 27487 6 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 481 9 2 8 3.7 COc1ccccc1-n1c(CNC(=O)c2ccco2)nnc1SCC(=O)Nc1ccc(F)cc1 nan
3484193 54320 12 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 443 6 2 6 4.0 CCOC(=O)c1c(NC(=O)C2C3CCC(O3)C2C(=O)O)sc(C)c1-c1ccc(C)cc1 nan
CHEMBL1546060 54320 12 None - 0 Human 4.2 pKi = 4.2 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 443 6 2 6 4.0 CCOC(=O)c1c(NC(=O)C2C3CCC(O3)C2C(=O)O)sc(C)c1-c1ccc(C)cc1 nan
5904 107168 40 None - 1 Human 5.1 pKi = 5.1 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 334 4 2 4 0.9 CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O nan
CHEMBL1223 107168 40 None - 1 Human 5.1 pKi = 5.1 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 334 4 2 4 0.9 CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O nan
CHEMBL29 107168 40 None - 1 Human 5.1 pKi = 5.1 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 334 4 2 4 0.9 CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O nan
2218678 47777 11 None - 0 Human 5.1 pKi = 5.1 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 325 8 0 3 2.7 CC(C)CN(CC(C)C)C(=O)CS(=O)(=O)Cc1ccccc1 nan
CHEMBL1487270 47777 11 None - 0 Human 5.1 pKi = 5.1 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 325 8 0 3 2.7 CC(C)CN(CC(C)C)C(=O)CS(=O)(=O)Cc1ccccc1 nan
1306464 36668 18 None - 0 Human 5.1 pKi = 5.1 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 376 4 0 6 4.6 COc1ccccc1-c1c(C)oc2cc(OC(=O)c3ccco3)ccc2c1=O nan
CHEMBL1388022 36668 18 None - 0 Human 5.1 pKi = 5.1 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 376 4 0 6 4.6 COc1ccccc1-c1c(C)oc2cc(OC(=O)c3ccco3)ccc2c1=O nan
135468407 55765 1 None - 0 Human 5.0 pKi = 5.0 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 498 7 2 10 4.0 COc1ccc(Cl)cc1-n1c(=S)sc2c(O)nc(SCC(=O)NCC3CCCO3)nc21 nan
CHEMBL1560619 55765 1 None - 0 Human 5.0 pKi = 5.0 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 498 7 2 10 4.0 COc1ccc(Cl)cc1-n1c(=S)sc2c(O)nc(SCC(=O)NCC3CCCO3)nc21 nan
2911378 51085 13 None - 0 Human 5.0 pKi = 5.0 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 416 8 1 6 4.0 C=CCOc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2Cc2cccnc2)cc1 nan
CHEMBL1517647 51085 13 None - 0 Human 5.0 pKi = 5.0 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 416 8 1 6 4.0 C=CCOc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2Cc2cccnc2)cc1 nan
5739108 52264 8 None - 0 Human 5.0 pKi = 5.0 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 482 8 2 8 2.1 COC(=O)c1[nH]c(C)c(C(=O)C2=C(O)C(=O)N(CCCN3CCOCC3)C2c2ccccn2)c1C nan
CHEMBL1528253 52264 8 None - 0 Human 5.0 pKi = 5.0 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 482 8 2 8 2.1 COC(=O)c1[nH]c(C)c(C(=O)C2=C(O)C(=O)N(CCCN3CCOCC3)C2c2ccccn2)c1C nan
2918378 31549 14 None - 0 Human 5.0 pKi = 5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 421 9 1 7 3.5 CCOc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCCn2ccnc2)cc1 nan
CHEMBL1344524 31549 14 None - 0 Human 5.0 pKi = 5 Functional
PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory) PubChem BioAssay. Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands. (Class of assay: confirmatory)
ChEMBL 421 9 1 7 3.5 CCOc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCCn2ccnc2)cc1 nan
1024 8072 71 None 16 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central None None None None None
162639143 8072 71 None 16 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central None None None None None
5284373 8072 71 None 16 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central None None None None None
760 8072 71 None 16 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central None None None None None
CHEMBL160 8072 71 None 16 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central None None None None None
DB00091 8072 71 None 16 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central None None None None None
1023 8454 0 None 100 5 Mouse 10.0 pEC50 = 10 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23160941
1022 8450 55 None 4897 3 Human 10.2 pEC50 = 10.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1262785
1022 8450 55 None 4897 3 Human 10.2 pEC50 = 10.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7387981
443295 8450 55 None 4897 3 Human 10.2 pEC50 = 10.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1262785
443295 8450 55 None 4897 3 Human 10.2 pEC50 = 10.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7387981
CHEMBL267179 8450 55 None 4897 3 Human 10.2 pEC50 = 10.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1262785
CHEMBL267179 8450 55 None 4897 3 Human 10.2 pEC50 = 10.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7387981
1021 8447 0 None 10 2 Human 10.5 pEC50 = 10.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2825171
5841 8449 0 None 125 4 Mouse 10.7 pEC50 = 10.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23160941
1026 10424 0 None -2 2 Mouse 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11714831
3081832 10424 0 None -2 2 Mouse 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11714831
CHEMBL395493 10424 0 None -2 2 Mouse 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11714831
1022 8450 55 None -4897 3 Mouse 4.7 pEC50 = 4.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10477558
1022 8450 55 None -4897 3 Mouse 4.7 pEC50 = 4.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18606697
443295 8450 55 None -4897 3 Mouse 4.7 pEC50 = 4.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10477558
443295 8450 55 None -4897 3 Mouse 4.7 pEC50 = 4.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18606697
CHEMBL267179 8450 55 None -4897 3 Mouse 4.7 pEC50 = 4.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10477558
CHEMBL267179 8450 55 None -4897 3 Mouse 4.7 pEC50 = 4.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18606697
3901842 7095 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 358 6 2 6 3.2 COc1ccc2c(c1)nc([nH]2)SCC(=O)Nc1ccc(cc1)[N+](=O)[O-] 19903830
5833 7095 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 358 6 2 6 3.2 COc1ccc2c(c1)nc([nH]2)SCC(=O)Nc1ccc(cc1)[N+](=O)[O-] 19903830
CHEMBL1290578 7095 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 358 6 2 6 3.2 COc1ccc2c(c1)nc([nH]2)SCC(=O)Nc1ccc(cc1)[N+](=O)[O-] 19903830
5832 7096 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 359 6 2 5 4.0 COc1ccc2c(c1)nc([nH]2)SCC(=O)Nc1ccc(cc1)SC 22127612
7342912 7096 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 359 6 2 5 4.0 COc1ccc2c(c1)nc([nH]2)SCC(=O)Nc1ccc(cc1)SC 22127612
1044 7213 0 None -1 3 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10882119
1044 7213 0 None -1 3 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12560218
5834 7943 0 None -1 2 Human 6.0 pEC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 517 7 1 5 5.1 COc1cccc(c1)Cc1cc(C)nn(c1=O)[C@@H](C(=O)Nc1ccc(cc1)Br)c1ccccc1 22607879
73755161 7943 0 None -1 2 Human 6.0 pEC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 517 7 1 5 5.1 COc1cccc(c1)Cc1cc(C)nn(c1=O)[C@@H](C(=O)Nc1ccc(cc1)Br)c1ccccc1 22607879
1024 8072 71 None 16 5 Human 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9310346
162639143 8072 71 None 16 5 Human 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9310346
5284373 8072 71 None 16 5 Human 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9310346
760 8072 71 None 16 5 Human 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9310346
CHEMBL160 8072 71 None 16 5 Human 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9310346
DB00091 8072 71 None 16 5 Human 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9310346
155817478 8566 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15699157
5839 8566 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15699157
11024 7475 19 None -12 4 Mouse 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 32407089
122583088 7475 19 None -12 4 Mouse 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 32407089
CHEMBL4784510 7475 19 None -12 4 Mouse 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 32407089
11024 7475 19 None -177 4 Human 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 32407089
122583088 7475 19 None -177 4 Human 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 32407089
CHEMBL4784510 7475 19 None -177 4 Human 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 32407089
1031 7212 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11395373
1031 7212 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17948261
5835 7097 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 404 7 1 6 3.8 COc1cc(/C=N/NC(=O)c2ccc3c(c2)OCO3)ccc1OCc1ccccc1 17229869
9618971 7097 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 404 7 1 6 3.8 COc1cc(/C=N/NC(=O)c2ccc3c(c2)OCO3)ccc1OCc1ccccc1 17229869
CHEMBL1290251 7097 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 404 7 1 6 3.8 COc1cc(/C=N/NC(=O)c2ccc3c(c2)OCO3)ccc1OCc1ccccc1 17229869
1023 8454 0 None -100 5 Human 8.0 pEC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16025565
5840 8451 0 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23160941
5838 10496 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10339497
5838 10496 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10860818
5841 8449 0 None -125 4 Human 8.6 pEC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16025565
5842 8448 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16025565
24776341 10013 39 None 20 4 Mouse 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 23160941
5831 10013 39 None 20 4 Mouse 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 23160941
CHEMBL379761 10013 39 None 20 4 Mouse 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 23160941
5837 8453 0 None - 1 Human 9.0 pEC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7559498
134813890 9295 0 None - 1 Human 9.0 pEC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7559498
5836 9295 0 None - 1 Human 9.0 pEC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7559498
1048 10857 0 None -3 4 Human 9.0 pEC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10586077
1048 10857 0 None -3 4 Mouse 9.0 pEC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11035102
1048 10857 0 None -3 4 Mouse 9.0 pEC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23160941
1021 8447 0 None -10 2 Mouse 9.5 pEC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23160941
4781 11112 98 None 67 2 Human 8.3 pIC50 = 8.3 Functional
NoneNone
Drug Central 308 5 0 2 3.8 CCCCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O None
CHEMBL101 11112 98 None 67 2 Human 8.3 pIC50 = 8.3 Functional
NoneNone
Drug Central 308 5 0 2 3.8 CCCCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O None
1026 10424 0 None 2 2 Human 4.3 pIC50 = 4.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11714831
1026 10424 0 None 2 2 Human 4.3 pIC50 = 4.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1373134
3081832 10424 0 None 2 2 Human 4.3 pIC50 = 4.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11714831
3081832 10424 0 None 2 2 Human 4.3 pIC50 = 4.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1373134
CHEMBL395493 10424 0 None 2 2 Human 4.3 pIC50 = 4.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11714831
CHEMBL395493 10424 0 None 2 2 Human 4.3 pIC50 = 4.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1373134
2528 10472 85 None - 1 Human 5.0 pIC50 = 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 15964939
5342 10472 85 None - 1 Human 5.0 pIC50 = 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 15964939
5826 10472 85 None - 1 Human 5.0 pIC50 = 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 15964939
CHEMBL832 10472 85 None - 1 Human 5.0 pIC50 = 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 15964939
DB01138 10472 85 None - 1 Human 5.0 pIC50 = 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 15964939
5322194 8646 10 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 3 1 5 2.3 CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C 16118363
5827 8646 10 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 3 1 5 2.3 CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C 16118363
CHEMBL1770295 8646 10 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 3 1 5 2.3 CC(C(N1C(=S)S/C(=C\2/c3ccccc3N(C2=O)C)/C1=O)C(=O)O)C 16118363
1029 10534 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1653806
4329947 9279 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 21486695
5829 9279 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 21486695
CHEMBL1770297 9279 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 21486695
53233899 8193 0 None 69 2 Human 6.5 pIC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 21486695
5830 8193 0 None 69 2 Human 6.5 pIC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 21486695
CHEMBL1770298 8193 0 None 69 2 Human 6.5 pIC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 21486695
1030 10533 0 None 28 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1653806
5825 7538 0 None - 1 Human 7.0 pIC50 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 329 2 2 2 4.9 Cc1ccc(c(c1)NC(=O)c1cc(Cl)cc(c1O)Cl)Cl 22410002
73755160 7538 0 None - 1 Human 7.0 pIC50 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 329 2 2 2 4.9 Cc1ccc(c(c1)NC(=O)c1cc(Cl)cc(c1O)Cl)Cl 22410002
1028 8748 0 None - 1 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8573582


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
CHEMBL5276622 200686 0 None - 0 Human 9.2 pEC50 = 9.2 Binding
Agonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 385 7 4 3 2.2 CC(C)C[C@H](NC(=O)CNC(=O)Nc1ccc(Br)cc1)C(=O)O 10.1016/j.ejmech.2021.113167
11024 7475 19 None - 0 Mouse 9.2 pEC50 = 9.2 Binding
Agonist activity at mouse FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1016/j.ejmech.2021.113167
122583088 7475 19 None - 0 Mouse 9.2 pEC50 = 9.2 Binding
Agonist activity at mouse FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL4784510 7475 19 None - 0 Mouse 9.2 pEC50 = 9.2 Binding
Agonist activity at mouse FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL5267736 200316 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay
ChEMBL 463 6 2 3 4.5 COc1cc(F)c([C@H]2CCN(CC3CC3)C(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1 10.1016/j.ejmech.2021.113167
CHEMBL5275766 200650 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay
ChEMBL 448 6 2 4 3.9 COc1ccc([C@@H]2CCN(Cc3ccccn3)C(=O)[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5276203 200668 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay
ChEMBL 448 6 2 4 3.9 COc1ccc([C@H]2CCN(Cc3ccccn3)C(=O)[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5278464 200760 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay
ChEMBL 448 6 2 4 3.9 COc1ccc([C@H]2CCN(Cc3cccnc3)C(=O)[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5285824 201096 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay
ChEMBL 373 4 3 3 3.1 COc1ccc([C@H]2CCNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5286200 201117 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay
ChEMBL 473 7 2 3 5.3 COc1cc(F)c([C@H]2CCN(CCC(F)F)C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1 10.1016/j.ejmech.2021.113167
CHEMBL5290016 201269 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR1 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay
ChEMBL 437 5 2 5 4.3 COc1ccc([C@H]2CCN(c3ccnnc3)C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5284816 201046 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 342 5 3 2 3.3 CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5280720 200859 0 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 506 7 3 6 2.4 CS(=O)(=O)NCC1(c2ccc(N3CCC[C@@H](NC(=O)Nc4cnc(Cl)cn4)C3=O)cc2)CCC1 10.1016/j.ejmech.2021.113167
122592369 189799 0 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4793814 189799 0 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
122582962 189491 0 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 391 5 3 4 2.4 COc1ccc(NC(=O)N[C@@H]2C(=O)NC[C@H]2c2c(F)cc(OC)cc2F)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4789579 189491 0 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 391 5 3 4 2.4 COc1ccc(NC(=O)N[C@@H]2C(=O)NC[C@H]2c2c(F)cc(OC)cc2F)cc1 10.1021/acs.jmedchem.9b02101
122583080 189588 0 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 391 4 4 4 2.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4790836 189588 0 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 391 4 4 4 2.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
122487986 182753 0 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assayAgonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
CHEMBL4588649 182753 0 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assayAgonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
122488043 181045 0 None - 0 Human 5.0 pEC50 = 5 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 427 7 1 6 3.5 COc1ccc(OC)c(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL4549250 181045 0 None - 0 Human 5.0 pEC50 = 5 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 427 7 1 6 3.5 COc1ccc(OC)c(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL5287909 201179 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 460 4 2 3 5.0 O=C(Nc1ccc(C(F)(F)F)cc1)N[C@@H]1CCCN(c2ccc(N3CCCCC3)cc2)C1=O 10.1016/j.ejmech.2021.113167
122582941 187778 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 395 4 3 3 3.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4758920 187778 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 395 4 3 3 3.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5276320 200672 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 492 6 3 4 4.4 COc1ccc(NC(=O)N[C@@H]2CCCN(c3ccc(-c4ccccc4C(N)=O)cc3)C2=O)cc1Cl 10.1016/j.ejmech.2021.113167
122583133 187941 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 401 4 3 4 3.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4760897 187941 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 401 4 3 4 3.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1 10.1021/acs.jmedchem.9b02101
122487981 180526 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 397 6 1 5 3.4 COc1ccccc1Cc1cc(C)nn(CC(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4536766 180526 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 397 6 1 5 3.4 COc1ccccc1Cc1cc(C)nn(CC(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
155555898 181146 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4551649 181146 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL5285738 201092 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 399 4 2 4 2.6 O=C(Cn1c(=O)[nH]cc(-c2ccccc2)c1=O)Nc1ccc(Br)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5283998 201016 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assayAgonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn([C@@H](C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
CHEMBL5284816 201046 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 342 5 3 2 3.3 CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5279215 200798 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 484 9 4 5 3.9 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(O)cc3)CC2)cc1 10.1016/j.ejmech.2021.113167
155516247 176808 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 411 6 1 5 4.0 COc1ccccc1Cc1cc(C)nn(C(C)C(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4442702 176808 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 411 6 1 5 4.0 COc1ccccc1Cc1cc(C)nn(C(C)C(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL5280317 200839 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 419 7 4 3 2.4 O=C(CNC(=O)Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.ejmech.2021.113167
CHEMBL5265989 200246 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 484 9 4 5 3.9 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3cccc(O)c3)CC2)cc1 10.1016/j.ejmech.2021.113167
155519369 177157 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 441 7 1 6 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1OC 10.1021/acs.jmedchem.8b01912
CHEMBL4447830 177157 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 441 7 1 6 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1OC 10.1021/acs.jmedchem.8b01912
122487974 177193 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 497 9 1 5 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4448213 177193 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 497 9 1 5 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL5273815 200560 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 474 4 2 4 3.9 O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CCCN(c2ccc(N3CC4(COC4)C3)cc2)C1=O 10.1016/j.ejmech.2021.113167
CHEMBL5277178 200705 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 481 6 3 4 3.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)NC2(c3ccc4cc(OC)ccc4c3)CC2)c(F)c1 10.1016/j.ejmech.2021.113167
122582977 189062 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 377 4 3 2 3.1 CCc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4783963 189062 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 377 4 3 2 3.1 CCc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5280794 200863 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 459 9 4 4 4.0 COc1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5278883 200782 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 451 5 1 5 4.1 COc1cccc(-c2cc(C#N)c(C)n(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
155519289 177144 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 427 7 1 6 3.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1OC 10.1021/acs.jmedchem.8b01912
CHEMBL4447632 177144 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 427 7 1 6 3.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1OC 10.1021/acs.jmedchem.8b01912
118132901 186577 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F 10.1021/acs.jmedchem.9b02101
CHEMBL4744835 186577 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F 10.1021/acs.jmedchem.9b02101
118132868 188197 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cccc(F)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4763824 188197 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cccc(F)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
122487959 177216 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 443 5 1 4 4.2 Cc1cc(Cc2ccccc2F)c(=O)n(C(C)C(=O)Nc2ccc(Br)cc2)n1 10.1021/acs.jmedchem.8b01912
CHEMBL4448576 177216 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 443 5 1 4 4.2 Cc1cc(Cc2ccccc2F)c(=O)n(C(C)C(=O)Nc2ccc(Br)cc2)n1 10.1021/acs.jmedchem.8b01912
122487971 176395 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 443 5 1 4 4.2 Cc1cc(Cc2ccc(F)cc2)c(=O)n(C(C)C(=O)Nc2ccc(Br)cc2)n1 10.1021/acs.jmedchem.8b01912
CHEMBL4436651 176395 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 443 5 1 4 4.2 Cc1cc(Cc2ccc(F)cc2)c(=O)n(C(C)C(=O)Nc2ccc(Br)cc2)n1 10.1021/acs.jmedchem.8b01912
155540456 179730 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 425 7 1 5 4.4 CCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4517103 179730 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 425 7 1 5 4.4 CCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL5271505 200467 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assayAgonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assay
ChEMBL 455 6 1 5 3.9 COc1cccc(Cc2c(C)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
122582983 187316 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 362 4 3 4 1.8 COc1cnc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4753713 187316 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 362 4 3 4 1.8 COc1cnc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
122583086 188856 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 378 4 4 3 2.5 CNc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4781488 188856 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 378 4 4 3 2.5 CNc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
44413534 145157 0 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 398 3 2 4 4.8 Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL377226 145157 0 None - 0 Mouse 7.7 pEC50 = 7.7 Binding
Agonist activity at mouse FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 398 3 2 4 4.8 Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL5278986 200786 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 512 6 3 6 3.3 Cc1cnc(NC(=O)N[C@@H]2CCCN(c3ccc(-c4ccccc4NS(C)(=O)=O)cc3F)C2=O)cn1 10.1016/j.ejmech.2021.113167
122487958 180800 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 443 5 1 4 4.2 Cc1cc(Cc2cccc(F)c2)c(=O)n(C(C)C(=O)Nc2ccc(Br)cc2)n1 10.1021/acs.jmedchem.8b01912
CHEMBL4543016 180800 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 443 5 1 4 4.2 Cc1cc(Cc2cccc(F)c2)c(=O)n(C(C)C(=O)Nc2ccc(Br)cc2)n1 10.1021/acs.jmedchem.8b01912
CHEMBL5273627 200550 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 525 7 4 6 1.7 CS(=O)(=O)NCC1(c2ccc(N3C[C@@H](O)C[C@@H](NC(=O)Nc4ncc(Cl)cc4F)C3=O)cc2)CC1 10.1016/j.ejmech.2021.113167
44236328 202455 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL556625 202455 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL5283221 200971 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 469 5 3 3 3.6 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)NC2(c3cccc(C(F)(F)F)c3)CC2)c(F)c1 10.1016/j.ejmech.2021.113167
154706263 180348 2 None - 0 Human 6.6 pEC50 = 6.6 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 527 10 1 6 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4532583 180348 2 None - 0 Human 6.6 pEC50 = 6.6 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 527 10 1 6 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
122487965 176664 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 455 6 1 5 4.1 COc1ccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/acs.jmedchem.8b01912
CHEMBL4440569 176664 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 455 6 1 5 4.1 COc1ccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/acs.jmedchem.8b01912
155538591 179184 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 427 7 1 6 3.5 COc1cccc(OC)c1Cc1cc(C)nn(CC(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4476616 179184 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 427 7 1 6 3.5 COc1cccc(OC)c1Cc1cc(C)nn(CC(=O)Nc2ccc(Cl)cc2)c1=O 10.1021/acs.jmedchem.8b01912
122583076 188862 1 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4781596 188862 1 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
11024 7475 19 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
122583088 7475 19 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
CHEMBL4784510 7475 19 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
155514516 176639 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 439 7 1 5 4.6 COc1ccccc1Cc1cc(C)nn(C(C(=O)Nc2ccc(Cl)cc2)C(C)C)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4440250 176639 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 439 7 1 5 4.6 COc1ccccc1Cc1cc(C)nn(C(C(=O)Nc2ccc(Cl)cc2)C(C)C)c1=O 10.1021/acs.jmedchem.8b01912
162673503 189779 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 365 3 3 2 3.0 O=C(Nc1ccc(F)cc1)N[C@@H]1C(=O)NC[C@H]1c1ccc(Cl)cc1F 10.1021/acs.jmedchem.9b02101
CHEMBL4793557 189779 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 365 3 3 2 3.0 O=C(Nc1ccc(F)cc1)N[C@@H]1C(=O)NC[C@H]1c1ccc(Cl)cc1F 10.1021/acs.jmedchem.9b02101
122582929 188640 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 382 4 3 5 2.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc(C)ns2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4778725 188640 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 382 4 3 5 2.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc(C)ns2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5291461 201312 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 435 6 2 5 4.3 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(C(F)F)cc3)on2)c(F)c1 10.1016/j.ejmech.2021.113167
118132864 186513 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4744094 186513 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL5283999 201017 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 547 5 2 5 4.9 CC1(C)CN(c2ccc(-c3ccccc3P(C)(C)=O)c(F)c2F)C(=O)[C@@H]1NC(=O)Nc1cnc(Cl)cn1 10.1016/j.ejmech.2021.113167
122582964 186980 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 417 4 3 4 3.6 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc3ccccc3s2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4749577 186980 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 417 4 3 4 3.6 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc3ccccc3s2)c(F)c1 10.1021/acs.jmedchem.9b02101
118132864 186513 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4744094 186513 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL5284349 201030 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 512 6 3 4 4.7 CS(=O)(=O)Nc1ccccc1-c1ccc(N2CCC[C@@H](NC(=O)Nc3ccc(Cl)cc3)C2=O)cc1 10.1016/j.ejmech.2021.113167
122583009 188186 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 375 4 3 3 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4763673 188186 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 375 4 3 3 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5270733 200428 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 524 7 3 4 3.6 CS(=O)(=O)NCC1(c2ccc(N3CCC[C@@H](NC(=O)Nc4ccc(C(F)(F)F)cc4)C3=O)cc2)CC1 10.1016/j.ejmech.2021.113167
CHEMBL5284802 201044 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 595 7 3 6 4.6 COc1cc(-c2ccccc2NS(C)(=O)=O)ccc1N1CCC[C@@H](NC(=O)Nc2ncc(C(F)(F)F)cc2F)C1=O 10.1016/j.ejmech.2021.113167
154725143 182450 2 None - 0 Human 6.5 pEC50 = 6.5 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 497 9 1 5 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4581644 182450 2 None - 0 Human 6.5 pEC50 = 6.5 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 497 9 1 5 5.3 CCCCC(C(=O)Nc1ccc(Br)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
122487986 182753 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL4588649 182753 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
118132914 186371 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 386 4 3 4 2.2 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C#N)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4742149 186371 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 386 4 3 4 2.2 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C#N)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5284927 201051 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as increase in intracellular calcium mobilization incubated for 1 hr by Fluo-4 AM dye based fluorescence plate reader assayAgonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as increase in intracellular calcium mobilization incubated for 1 hr by Fluo-4 AM dye based fluorescence plate reader assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn([C@H](C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
CHEMBL5276878 200694 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 371 7 4 3 1.9 CCC[C@H](NC(=O)CNC(=O)Nc1ccc(Br)cc1)C(=O)O 10.1016/j.ejmech.2021.113167
118132792 188447 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 411 4 4 4 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4776349 188447 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 411 4 4 4 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
122582965 187716 0 None - 0 Human 4.4 pEC50 = 4.4 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 374 3 3 3 2.4 N#Cc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4758129 187716 0 None - 0 Human 4.4 pEC50 = 4.4 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 374 3 3 3 2.4 N#Cc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
118132818 186432 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 377 4 3 3 2.9 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(Cl)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4743133 186432 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 377 4 3 3 2.9 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(Cl)c1 10.1021/acs.jmedchem.9b02101
44413534 145157 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 398 3 2 4 4.8 Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL377226 145157 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 398 3 2 4 4.8 Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL5270501 200415 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 475 4 2 5 3.3 O=C(Nc1ccc(C(F)(F)F)cn1)N[C@@H]1CCCN(c2ccc(N3CC4(COC4)C3)cc2)C1=O 10.1016/j.ejmech.2021.113167
122487990 180644 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 391 7 1 5 3.4 CCc1ccc(NC(=O)Cn2nc(C)cc(Cc3ccccc3OC)c2=O)cc1 10.1021/acs.jmedchem.8b01912
CHEMBL4539397 180644 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 391 7 1 5 3.4 CCc1ccc(NC(=O)Cn2nc(C)cc(Cc3ccccc3OC)c2=O)cc1 10.1021/acs.jmedchem.8b01912
CHEMBL5284816 201046 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 342 5 3 2 3.3 CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1 10.1016/j.ejmech.2021.113167
24776341 10013 39 None - 0 Human 7.3 pEC50 = 7.3 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
5831 10013 39 None - 0 Human 7.3 pEC50 = 7.3 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
CHEMBL379761 10013 39 None - 0 Human 7.3 pEC50 = 7.3 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
CHEMBL5282050 200919 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 459 9 4 4 4.0 COc1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2021.113167
155523368 177564 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 415 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3F)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL4452950 177564 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 415 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3F)c2=O)c1 10.1021/acs.jmedchem.8b01912
44236326 202101 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL551589 202101 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
155555363 181153 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 439 8 1 5 4.8 CCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4551842 181153 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 439 8 1 5 4.8 CCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
122582903 189662 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 396 4 3 4 2.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cn2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4792002 189662 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 396 4 3 4 2.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cn2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5265951 200244 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 483 6 2 5 3.4 O=C(Nc1ccc(Cl)cn1)N[C@@H]1CCCN(c2ccc(C3(CN4CCOCC4)CC3)cc2)C1=O 10.1016/j.ejmech.2021.113167
118132817 187104 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F 10.1021/acs.jmedchem.9b02101
CHEMBL4751168 187104 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F 10.1021/acs.jmedchem.9b02101
122583049 187485 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 395 4 4 4 2.2 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4755590 187485 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 395 4 4 4 2.2 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
122487964 178948 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 395 6 1 5 3.5 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3cccc(F)c3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL4473444 178948 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 395 6 1 5 3.5 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3cccc(F)c3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL5284903 201050 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 399 8 4 3 2.6 CC(C)C[C@H](NC(=O)CCNC(=O)Nc1ccc(Br)cc1)C(=O)O 10.1016/j.ejmech.2021.113167
122583163 186429 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 357 4 3 3 2.5 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(C)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4743084 186429 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 357 4 3 3 2.5 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(C)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5284927 201051 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assayAgonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn([C@H](C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
122487986 182753 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as increase in intracellular calcium mobilization incubated for 1 hr by Fluo-4 AM dye based fluorescence plate reader assayAgonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as increase in intracellular calcium mobilization incubated for 1 hr by Fluo-4 AM dye based fluorescence plate reader assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
CHEMBL4588649 182753 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as increase in intracellular calcium mobilization incubated for 1 hr by Fluo-4 AM dye based fluorescence plate reader assayAgonist activity at human recombinant FPR1 stably transfected in Flp-In-CHO cells assessed as increase in intracellular calcium mobilization incubated for 1 hr by Fluo-4 AM dye based fluorescence plate reader assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
122487972 182554 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3ccccc3OC)c2=O)cc1 10.1021/acs.jmedchem.8b01912
CHEMBL4583846 182554 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3ccccc3OC)c2=O)cc1 10.1021/acs.jmedchem.8b01912
122582974 186212 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4740375 186212 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
122582993 188050 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 397 4 3 3 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4762030 188050 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 397 4 3 3 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
146035588 177675 2 None - 0 Human 7.1 pEC50 = 7.1 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4454594 177675 2 None - 0 Human 7.1 pEC50 = 7.1 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
146035588 177675 2 None - 0 Human 7.1 pEC50 = 7.1 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4454594 177675 2 None - 0 Human 7.1 pEC50 = 7.1 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
122487970 178416 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 455 6 1 5 4.1 COc1ccccc1Cc1cc(C)nn(C(C)C(=O)Nc2ccc(Br)cc2)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4465768 178416 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 455 6 1 5 4.1 COc1ccccc1Cc1cc(C)nn(C(C)C(=O)Nc2ccc(Br)cc2)c1=O 10.1021/acs.jmedchem.8b01912
122487968 181924 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 395 6 1 5 3.5 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL4569975 181924 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 395 6 1 5 3.5 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
122583126 186602 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4745044 186602 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5273792 200559 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 547 7 2 8 4.9 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Oc4ccc(C(F)(F)F)nc4)cc3)o2)c(F)c1 10.1016/j.ejmech.2021.113167
118132866 186487 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 343 4 3 3 2.2 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4743917 186487 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 343 4 3 3 2.2 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL5288471 201206 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR1 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 446 5 3 3 3.9 NC(=O)c1ccccc1-c1ccc(N2CCC[C@@H](NC(=O)Nc3ccc(F)cc3)C2=O)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5284145 201025 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assayAgonist activity at human FPR1 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assay
ChEMBL 455 6 1 5 3.9 COc1ccc(Cc2c(C)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2021.113167
118132917 189781 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4793603 189781 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
146035589 180508 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 483 10 1 6 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4536334 180508 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 483 10 1 6 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
122582974 186212 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4740375 186212 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
162659259 188012 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 439 4 3 3 3.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Br)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4761554 188012 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 439 4 3 3 3.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Br)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5284816 201046 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Agonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR1 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 342 5 3 2 3.3 CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1 10.1016/j.ejmech.2021.113167
CHEMBL6997 222645 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1cccc(C)c1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
53233899 8193 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation countingDisplacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation counting
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
5830 8193 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation countingDisplacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation counting
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL1770298 8193 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation countingDisplacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation counting
ChEMBL 394 5 3 4 4.5 Cc1ccc(s1)C(C(=O)Nc1c(C)cccc1C)NC(=O)c1ccccc1O 10.1016/j.bmcl.2011.03.049
CHEMBL268823 217547 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)NCC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7214 222649 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
155557362 181422 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at human Gi/o-coupled FPR1 expressed in CHOK1 cells assessed as reduction in WKYMVm-NH2-induced beta-arrestin 2 recruitment incubated for 30 mins followed by WKYMVm-NH2 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gi/o-coupled FPR1 expressed in CHOK1 cells assessed as reduction in WKYMVm-NH2-induced beta-arrestin 2 recruitment incubated for 30 mins followed by WKYMVm-NH2 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 560 6 1 6 5.4 CC[C@]12C=C(C(=O)OC)n3c(c(CCNC(=O)c4ccc(Br)cc4)c4ccccc43)[C@H]1N(C#N)CCC2 10.1021/acs.jmedchem.9b01924
CHEMBL4558185 181422 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at human Gi/o-coupled FPR1 expressed in CHOK1 cells assessed as reduction in WKYMVm-NH2-induced beta-arrestin 2 recruitment incubated for 30 mins followed by WKYMVm-NH2 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gi/o-coupled FPR1 expressed in CHOK1 cells assessed as reduction in WKYMVm-NH2-induced beta-arrestin 2 recruitment incubated for 30 mins followed by WKYMVm-NH2 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 560 6 1 6 5.4 CC[C@]12C=C(C(=O)OC)n3c(c(CCNC(=O)c4ccc(Br)cc4)c4ccccc43)[C@H]1N(C#N)CCC2 10.1021/acs.jmedchem.9b01924
CHEMBL2372498 217038 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@](O)(C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@H](O)[C@H](C)C/C=C/CO)N(C)C(=O)[C@H](C(C)C)N(C)C1=O 10.1021/jm010987v
70691873 80747 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL 1200 15 4 11 4.5 C/C=C/CC(C)C(C)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL2021596 80747 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL 1200 15 4 11 4.5 C/C=C/CC(C)C(C)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL2369724 216439 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@H]([C@H](C)CC)C(=O)N1C 10.1021/jm010987v
CHEMBL2372478 217032 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
44263999 211870 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL 558 15 5 6 3.3 COc1ccc(NC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)O)cc1 10.1021/jm950908d
CHEMBL7753 211870 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL 558 15 5 6 3.3 COc1ccc(NC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)O)cc1 10.1021/jm950908d
CHEMBL266802 217479 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1ccc(C)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL267388 217497 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
1022 8450 55 None 38 2 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None None 10.1021/jm950908d
443295 8450 55 None 38 2 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None None 10.1021/jm950908d
CHEMBL267179 8450 55 None 38 2 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None None 10.1021/jm950908d
9988173 168695 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL 862 21 7 6 5.5 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL415296 168695 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL 862 21 7 6 5.5 CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7122 222647 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)NC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7486 222653 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None Cc1cccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm950908d
CHEMBL266448 217463 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CCCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7034 222646 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)NC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7306 222651 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CSCC[C@H](NC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL2372474 217029 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](C)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL2372461 217026 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL2372504 217039 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@](O)(C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL2372477 217031 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C)C(=O)N1C 10.1021/jm010987v
CHEMBL7520 222654 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL265408 217426 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CCCCNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL266089 217455 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None C=C(C)NC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7363 222652 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CCCCNC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL2372488 217036 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@](O)(C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL415299 219961 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7181 222648 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CNC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL2372495 217037 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
4329947 9279 1 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation countingDisplacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation counting
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
5829 9279 1 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation countingDisplacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation counting
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
CHEMBL1770297 9279 1 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation countingDisplacement of [3H]fMLF from human FPR1 expressed in CHO cells by scintillation counting
ChEMBL 423 8 2 5 5.2 CSCCC(c1nc2c([nH]1)cccc2)NC(=O)c1oc2c(c1C)cc(cc2)OCC 10.1016/j.bmcl.2011.03.049
CHEMBL2372506 217041 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL2372456 217025 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CCC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](CCC)C(=O)N(C)[C@H](CC(C)C)C(=O)NC(C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL162488 215589 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)Nc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL2370883 216721 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)C1NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](C(C)C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm010987v
CHEMBL2372486 217034 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@](O)(C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL2372507 217042 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@](O)(C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL2372505 217040 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL2372473 217028 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None CC/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](CCCCN)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL2372476 217030 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None CC[C@@H]1NC(=O)[C@H](CC2CCCCC2)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](C(C)C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)CN(C)C1=O 10.1021/jm010987v
CHEMBL2370885 216722 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)C1NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](C(C)C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC1=O 10.1021/jm010987v
CHEMBL2372466 217027 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None CC/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL2372487 217035 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@](O)(C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
CHEMBL6450 222633 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL7226 222650 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL None None None CSCC[C@H](NC(=O)NCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
10579232 210515 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL 586 14 5 5 3.7 CSCC[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL6779 210515 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards fMLF receptor using human neutrophilsBinding affinity towards fMLF receptor using human neutrophils
ChEMBL 586 14 5 5 3.7 CSCC[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950908d
CHEMBL2372485 217033 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cellsInhibitory activity against human formylpeptide receptor (FPR) of human leukemia HL-60 cells
ChEMBL None None None C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@H](CC(C)C)C(=O)N[C@H](C(C)C)C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C 10.1021/jm010987v
1022 8450 55 None 38 2 Human 8.5 pKd = 8.5 Binding
Binding affinity to human FPR1 receptorBinding affinity to human FPR1 receptor
ChEMBL None None None None 10.1021/jm501018q
443295 8450 55 None 38 2 Human 8.5 pKd = 8.5 Binding
Binding affinity to human FPR1 receptorBinding affinity to human FPR1 receptor
ChEMBL None None None None 10.1021/jm501018q
CHEMBL267179 8450 55 None 38 2 Human 8.5 pKd = 8.5 Binding
Binding affinity to human FPR1 receptorBinding affinity to human FPR1 receptor
ChEMBL None None None None 10.1021/jm501018q
1022 8450 55 None 38 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-fMLP from FPR in human neutrophilsDisplacement of [3H]-fMLP from FPR in human neutrophils
ChEMBL None None None None 10.1016/j.bmcl.2007.04.036
443295 8450 55 None 38 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-fMLP from FPR in human neutrophilsDisplacement of [3H]-fMLP from FPR in human neutrophils
ChEMBL None None None None 10.1016/j.bmcl.2007.04.036
CHEMBL267179 8450 55 None 38 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-fMLP from FPR in human neutrophilsDisplacement of [3H]-fMLP from FPR in human neutrophils
ChEMBL None None None None 10.1016/j.bmcl.2007.04.036
5843 8452 0 None - 1 Mouse 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23160941
10133 7697 78 None - 1 Human 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
145714624 7697 78 None - 1 Human 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
4361 7697 78 None - 1 Human 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
608 7697 78 None - 1 Human 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
CHEMBL240597 7697 78 None - 1 Human 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
DB06777 7697 78 None - 1 Human 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
222528 8150 81 None - 1 Human 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
4988 8150 81 None - 1 Human 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
610 8150 81 None - 1 Human 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
CHEMBL406393 8150 81 None - 1 Human 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
DB03619 8150 81 None - 1 Human 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
2528 10472 85 None - 1 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 None
5342 10472 85 None - 1 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 None
5826 10472 85 None - 1 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 None
CHEMBL832 10472 85 None - 1 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 None
DB01138 10472 85 None - 1 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 404 6 0 3 3.8 O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1 None
10133 7697 78 None - 1 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 11211928
145714624 7697 78 None - 1 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 11211928
4361 7697 78 None - 1 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 11211928
608 7697 78 None - 1 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 11211928
CHEMBL240597 7697 78 None - 1 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 11211928
DB06777 7697 78 None - 1 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 11211928
222528 8150 81 None - 1 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 11853704
4988 8150 81 None - 1 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 11853704
610 8150 81 None - 1 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 11853704
CHEMBL406393 8150 81 None - 1 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 11853704
DB03619 8150 81 None - 1 Human 4.0 pKi = 4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 11853704
1030 10533 0 None - 1 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8387097
1025 8073 0 None - 1 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17082621
1025 8073 0 None - 1 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8387097
3092570 6880 12 None - 1 Human 7.0 pKi = 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 376 3 0 6 4.1 CCc1cc2c(cc1OC(=O)C)oc(c(c2=O)c1nc2c(n1C)cccc2)C 19807662
5828 6880 12 None - 1 Human 7.0 pKi = 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 376 3 0 6 4.1 CCc1cc2c(cc1OC(=O)C)oc(c(c2=O)c1nc2c(n1C)cccc2)C 19807662
CHEMBL1329101 6880 12 None - 1 Human 7.0 pKi = 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 376 3 0 6 4.1 CCc1cc2c(cc1OC(=O)C)oc(c(c2=O)c1nc2c(n1C)cccc2)C 19807662