Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| CHEMBL2372985 | 217111 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2372997 | 217119 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2372993 | 217115 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2373004 | 217126 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCNC(N)=O)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2370125 | 216568 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | None | None | None | C[C@H](NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2179708 | 216220 | 0 | None | - | 1 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2221068 | 216220 | 0 | None | - | 1 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2370130 | 216571 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCNC(N)=O)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2370132 | 216572 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2179708 | 216220 | 0 | None | - | 1 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2221068 | 216220 | 0 | None | - | 1 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2370133 | 216573 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2370136 | 216576 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2370140 | 216579 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | None | None | None | C[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2370105 | 216560 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2370139 | 216578 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2370134 | 216574 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL192685 | 215870 | 1 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180080 | 215870 | 1 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL191687 | 215860 | 1 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | None | None | None | C[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180081 | 215860 | 1 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | None | None | None | C[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL192685 | 215870 | 1 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180080 | 215870 | 1 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm300926y | ||||
| 72736900 | 169023 | 0 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 705 | 13 | 12 | 8 | -1.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](C/C=C/c2ccccc2)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4163529 | 169023 | 0 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 705 | 13 | 12 | 8 | -1.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](C/C=C/c2ccccc2)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL191687 | 215860 | 1 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | None | None | None | C[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180081 | 215860 | 1 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | None | None | None | C[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2372989 | 217113 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2373002 | 217124 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2370108 | 216562 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2370126 | 216569 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | None | None | None | C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| 72737246 | 169248 | 0 | None | - | 1 | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 725 | 10 | 10 | 7 | -0.6 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]2Cc3ccccc3CN2C(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4167050 | 169248 | 0 | None | - | 1 | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 725 | 10 | 10 | 7 | -0.6 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]2Cc3ccccc3CN2C(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL2180084 | 216218 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)C2(CCN(C(=N)N)CC2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220522 | 216218 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)C2(CCN(C(=N)N)CC2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180084 | 216218 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)C2(CCN(C(=N)N)CC2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220522 | 216218 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)C2(CCN(C(=N)N)CC2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2179712 | 216219 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2221016 | 216219 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2179712 | 216219 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2221016 | 216219 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| 72736898 | 168807 | 0 | None | - | 1 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 699 | 13 | 12 | 8 | -1.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](CCC2CCCCC2)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4159875 | 168807 | 0 | None | - | 1 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 699 | 13 | 12 | 8 | -1.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](CCC2CCCCC2)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL2372983 | 217110 | 0 | None | -32 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| 16130395 | 10495 | 16 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00535-7 | ||||
| 56947144 | 10495 | 16 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00535-7 | ||||
| 73345443 | 10495 | 16 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00535-7 | ||||
| 853 | 10495 | 16 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2370138 | 10495 | 16 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | None | None | None | None | 10.1016/s0960-894x(00)00535-7 | ||||
| 72736896 | 169592 | 0 | None | - | 1 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 693 | 13 | 12 | 8 | -1.8 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](CCc2ccccc2)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4172495 | 169592 | 0 | None | - | 1 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 693 | 13 | 12 | 8 | -1.8 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](CCc2ccccc2)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL2180079 | 216213 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | None | None | None | CC1(C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220430 | 216213 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | None | None | None | CC1(C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2373005 | 217127 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCNC(N)=O)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2370127 | 216570 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2180079 | 216213 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | None | None | None | CC1(C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220430 | 216213 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | None | None | None | CC1(C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180078 | 216212 | 0 | None | - | 1 | Human | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220429 | 216212 | 0 | None | - | 1 | Human | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180078 | 216212 | 0 | None | - | 1 | Human | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220429 | 216212 | 0 | None | - | 1 | Human | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2373000 | 217122 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCNC(N)=O)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2372994 | 217116 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2370135 | 216575 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2373001 | 217123 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2373003 | 217125 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCNC(N)=O)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL3038228 | 217725 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | C[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(=O)O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL3327368 | 218167 | 0 | None | - | 1 | Human | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmc.2014.07.004 | ||||
| CHEMBL3327368 | 218167 | 0 | None | - | 1 | Human | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmc.2014.07.004 | ||||
| CHEMBL2370109 | 216563 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| 5275843 | 220457 | 31 | None | 32 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180076 | 220457 | 31 | None | 32 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL436283 | 220457 | 31 | None | 32 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2370106 | 216561 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| 5275843 | 220457 | 31 | None | 32 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180076 | 220457 | 31 | None | 32 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL436283 | 220457 | 31 | None | 32 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| 72737615 | 169470 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 623 | 10 | 11 | 7 | -2.4 | N=C(N)NCCC[C@@H]1NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4170463 | 169470 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 623 | 10 | 11 | 7 | -2.4 | N=C(N)NCCC[C@@H]1NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| 11505556 | 168758 | 0 | None | - | 1 | Human | 4.3 | pEC50 | = | 4.3 | Functional | ChEMBL | 637 | 10 | 11 | 7 | -2.0 | C[C@H]1NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4159140 | 168758 | 0 | None | - | 1 | Human | 4.3 | pEC50 | = | 4.3 | Functional | ChEMBL | 637 | 10 | 11 | 7 | -2.0 | C[C@H]1NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL2180077 | 220456 | 1 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmc.2014.07.004 | ||||
| CHEMBL436097 | 220456 | 1 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmc.2014.07.004 | ||||
| CHEMBL2180077 | 220456 | 1 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmc.2014.07.004 | ||||
| CHEMBL436097 | 220456 | 1 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmc.2014.07.004 | ||||
| CHEMBL2180082 | 216216 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)C2(CCCCC2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220520 | 216216 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)C2(CCCCC2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180082 | 216216 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)C2(CCCCC2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220520 | 216216 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)C2(CCCCC2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL3038227 | 217724 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | None | None | None | CC(N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2180083 | 216217 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)C2(CCNCC2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220521 | 216217 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)C2(CCNCC2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| 72737063 | 169685 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 729 | 12 | 12 | 8 | -1.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2cccc3ccccc23)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4173917 | 169685 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 729 | 12 | 12 | 8 | -1.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2cccc3ccccc23)NC1=O | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL2180083 | 216217 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)C2(CCNCC2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220521 | 216217 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)C2(CCNCC2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| 118712250 | 120877 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 468 | 14 | 8 | 4 | 0.9 | N=C(N)NCCCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCc1ccc2ccccc2c1 | 10.1016/j.bmc.2014.07.004 | ||
| CHEMBL3327366 | 120877 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 468 | 14 | 8 | 4 | 0.9 | N=C(N)NCCCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCc1ccc2ccccc2c1 | 10.1016/j.bmc.2014.07.004 | ||
| 118712250 | 120877 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 468 | 14 | 8 | 4 | 0.9 | N=C(N)NCCCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCc1ccc2ccccc2c1 | 10.1016/j.bmc.2014.07.004 | ||
| CHEMBL3327366 | 120877 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 468 | 14 | 8 | 4 | 0.9 | N=C(N)NCCCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCc1ccc2ccccc2c1 | 10.1016/j.bmc.2014.07.004 | ||
| 145972431 | 169819 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 361 | 5 | 1 | 5 | 2.7 | O=C(c1ccc(-n2cccn2)nc1)N1CCC(NCc2ccccc2)CC1 | 10.1016/j.ejmech.2018.05.013 | ||
| CHEMBL4176060 | 169819 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 361 | 5 | 1 | 5 | 2.7 | O=C(c1ccc(-n2cccn2)nc1)N1CCC(NCc2ccccc2)CC1 | 10.1016/j.ejmech.2018.05.013 | ||
| CHEMBL2372999 | 217121 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCNC(N)=O)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2372995 | 217117 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL3327373 | 218168 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmc.2014.07.004 | ||||
| CHEMBL3327373 | 218168 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmc.2014.07.004 | ||||
| 134144488 | 157566 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 602 | 10 | 6 | 5 | 2.4 | N=C(N)NCCCC1CSC2CN(Cc3ccc4ccccc4c3Br)C(=O)[C@H](CCCNC(=N)N)N2C1=O | 10.1016/j.bmc.2016.11.036 | ||
| CHEMBL3956669 | 157566 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 602 | 10 | 6 | 5 | 2.4 | N=C(N)NCCCC1CSC2CN(Cc3ccc4ccccc4c3Br)C(=O)[C@H](CCCNC(=N)N)N2C1=O | 10.1016/j.bmc.2016.11.036 | ||
| 134144488 | 157566 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 602 | 10 | 6 | 5 | 2.4 | N=C(N)NCCCC1CSC2CN(Cc3ccc4ccccc4c3Br)C(=O)[C@H](CCCNC(=N)N)N2C1=O | 10.1016/j.bmc.2016.11.036 | ||
| CHEMBL3956669 | 157566 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 602 | 10 | 6 | 5 | 2.4 | N=C(N)NCCCC1CSC2CN(Cc3ccc4ccccc4c3Br)C(=O)[C@H](CCCNC(=N)N)N2C1=O | 10.1016/j.bmc.2016.11.036 | ||
| 118712261 | 120879 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 538 | 11 | 6 | 5 | 1.6 | N=C(N)NCCC[C@@H]1CS[C@@H]2CN(CCc3ccc4ccccc4c3)C(=O)[C@H](CCCNC(=N)N)N2C1=O | 10.1016/j.bmc.2014.07.004 | ||
| CHEMBL3327376 | 120879 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 538 | 11 | 6 | 5 | 1.6 | N=C(N)NCCC[C@@H]1CS[C@@H]2CN(CCc3ccc4ccccc4c3)C(=O)[C@H](CCCNC(=N)N)N2C1=O | 10.1016/j.bmc.2014.07.004 | ||
| 118712261 | 120879 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 538 | 11 | 6 | 5 | 1.6 | N=C(N)NCCC[C@@H]1CS[C@@H]2CN(CCc3ccc4ccccc4c3)C(=O)[C@H](CCCNC(=N)N)N2C1=O | 10.1016/j.bmc.2014.07.004 | ||
| CHEMBL3327376 | 120879 | 0 | None | - | 1 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 538 | 11 | 6 | 5 | 1.6 | N=C(N)NCCC[C@@H]1CS[C@@H]2CN(CCc3ccc4ccccc4c3)C(=O)[C@H](CCCNC(=N)N)N2C1=O | 10.1016/j.bmc.2014.07.004 | ||
| CHEMBL2180085 | 216214 | 1 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220487 | 216214 | 1 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180085 | 216214 | 1 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220487 | 216214 | 1 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2179709 | 216221 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(NC(=N)N)cc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2221069 | 216221 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(NC(=N)N)cc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2372986 | 217112 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCNC(N)=O)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2179709 | 216221 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(NC(=N)N)cc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2221069 | 216221 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(NC(=N)N)cc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2372990 | 217114 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2372998 | 217120 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| CHEMBL2180086 | 216215 | 0 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220488 | 216215 | 0 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180086 | 216215 | 0 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2220488 | 216215 | 0 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180077 | 220456 | 1 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL436097 | 220456 | 1 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL2180077 | 220456 | 1 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| CHEMBL436097 | 220456 | 1 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm300926y | ||||
| 118712260 | 120878 | 0 | None | - | 1 | Human | 4.1 | pEC50 | = | 4.1 | Functional | ChEMBL | 538 | 11 | 6 | 5 | 1.6 | N=C(N)NCCC[C@H]1C(=O)N(CCc2ccc3ccccc3c2)C[C@@H]2SC[C@H](CCCNC(=N)N)C(=O)N21 | 10.1016/j.bmc.2014.07.004 | ||
| CHEMBL3327375 | 120878 | 0 | None | - | 1 | Human | 4.1 | pEC50 | = | 4.1 | Functional | ChEMBL | 538 | 11 | 6 | 5 | 1.6 | N=C(N)NCCC[C@H]1C(=O)N(CCc2ccc3ccccc3c2)C[C@@H]2SC[C@H](CCCNC(=N)N)C(=O)N21 | 10.1016/j.bmc.2014.07.004 | ||
| CHEMBL2370104 | 216559 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2372996 | 217118 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| 118712260 | 120878 | 0 | None | - | 1 | Human | 4.1 | pEC50 | = | 4.1 | Functional | ChEMBL | 538 | 11 | 6 | 5 | 1.6 | N=C(N)NCCC[C@H]1C(=O)N(CCc2ccc3ccccc3c2)C[C@@H]2SC[C@H](CCCNC(=N)N)C(=O)N21 | 10.1016/j.bmc.2014.07.004 | ||
| CHEMBL3327375 | 120878 | 0 | None | - | 1 | Human | 4.1 | pEC50 | = | 4.1 | Functional | ChEMBL | 538 | 11 | 6 | 5 | 1.6 | N=C(N)NCCC[C@H]1C(=O)N(CCc2ccc3ccccc3c2)C[C@@H]2SC[C@H](CCCNC(=N)N)C(=O)N21 | 10.1016/j.bmc.2014.07.004 | ||
| CHEMBL3327367 | 218166 | 0 | None | - | 1 | Human | 4.1 | pEC50 | = | 4.1 | Functional | ChEMBL | None | None | None | CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O | 10.1016/j.bmc.2014.07.004 | ||||
| CHEMBL3327367 | 218166 | 0 | None | - | 1 | Human | 4.1 | pEC50 | = | 4.1 | Functional | ChEMBL | None | None | None | CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O | 10.1016/j.bmc.2014.07.004 | ||||
| 24066 | 212833 | 103 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 211 | 2 | 2 | 6 | -0.5 | Nc1ccn([C@H]2CC[C@@H](CO)O2)c(=O)n1 | 10.1016/s0960-894x(01)00323-7 | ||
| CHEMBL853 | 212833 | 103 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 211 | 2 | 2 | 6 | -0.5 | Nc1ccn([C@H]2CC[C@@H](CO)O2)c(=O)n1 | 10.1016/s0960-894x(01)00323-7 | ||
| CHEMBL2370124 | 216567 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCNC(N)=O)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| CHEMBL2370137 | 216577 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC1=O | 10.1016/s0960-894x(00)00535-7 | ||||
| 145958083 | 169100 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5.0 | Functional | ChEMBL | 321 | 7 | 2 | 5 | 2.5 | O=C(NCCCNc1ccccc1)c1ccc(-n2cccn2)nc1 | 10.1016/j.ejmech.2018.05.013 | ||
| CHEMBL4164659 | 169100 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5.0 | Functional | ChEMBL | 321 | 7 | 2 | 5 | 2.5 | O=C(NCCCNc1ccccc1)c1ccc(-n2cccn2)nc1 | 10.1016/j.ejmech.2018.05.013 | ||
| 11151928 | 196266 | 0 | None | -11 | 4 | Human | 9.0 | pED50 | = | 9 | Functional | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | ||
| CHEMBL513863 | 196266 | 0 | None | -11 | 4 | Human | 9.0 | pED50 | = | 9 | Functional | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O | 10.1021/jm900133w | ||
| 138501621 | 187137 | 3 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 366 | 4 | 0 | 6 | 2.4 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4751485 | 187137 | 3 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 366 | 4 | 0 | 6 | 2.4 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 138501464 | 190264 | 3 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 366 | 4 | 0 | 6 | 2.6 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4799439 | 190264 | 3 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 366 | 4 | 0 | 6 | 2.6 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| 138501432 | 189739 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 380 | 4 | 0 | 6 | 3.0 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)cc(N2CCCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4792975 | 189739 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 380 | 4 | 0 | 6 | 3.0 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)cc(N2CCCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| 145975799 | 170393 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)[C@H]3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4203703 | 170393 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)[C@H]3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 49857283 | 70587 | 10 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 472 | 10 | 3 | 9 | 3.0 | Fc1cnc(Cl)nc1NCc1ccc(CNc2ccnc(NCCN3CCOCC3)n2)cc1 | 10.1021/jm100786g | ||
| CHEMBL1802333 | 70587 | 10 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 472 | 10 | 3 | 9 | 3.0 | Fc1cnc(Cl)nc1NCc1ccc(CNc2ccnc(NCCN3CCOCC3)n2)cc1 | 10.1021/jm100786g | ||
| 11718722 | 23428 | 13 | None | -1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| CHEMBL1242210 | 23428 | 13 | None | -1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| CHEMBL4163246 | 219996 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.ejmech.2017.08.027 | ||||
| 76324529 | 110607 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 455 | 10 | 2 | 5 | 4.4 | c1ccc(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)nc1 | 10.1021/ml400183q | ||
| CHEMBL3091683 | 110607 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 455 | 10 | 2 | 5 | 4.4 | c1ccc(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)nc1 | 10.1021/ml400183q | ||
| 59176553 | 155246 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 566 | 10 | 1 | 7 | 5.6 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1nccc2c3ccccc3n(CCC3CCOCC3)c12 | nan | ||
| CHEMBL3938042 | 155246 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 566 | 10 | 1 | 7 | 5.6 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1nccc2c3ccccc3n(CCC3CCOCC3)c12 | nan | ||
| 44470245 | 157560 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 513 | 9 | 1 | 7 | 5.5 | CC(C)(C)OC(=O)Cn1c2ccccc2c2ccnc(CN(CCCCN)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3956608 | 157560 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 513 | 9 | 1 | 7 | 5.5 | CC(C)(C)OC(=O)Cn1c2ccccc2c2ccnc(CN(CCCCN)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 11718722 | 23428 | 13 | None | -1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| CHEMBL1242210 | 23428 | 13 | None | -1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| 25147749 | 8875 | 18 | None | -18 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/jm801065q | ||
| 2899 | 8875 | 18 | None | -18 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/jm801065q | ||
| CHEMBL460491 | 8875 | 18 | None | -18 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/jm801065q | ||
| 138501682 | 190249 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 384 | 4 | 0 | 6 | 2.7 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)c(F)c(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4799191 | 190249 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 384 | 4 | 0 | 6 | 2.7 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)c(F)c(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| 53323182 | 63683 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 388 | 6 | 2 | 6 | 3.5 | NCc1ncoc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644092 | 63683 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 388 | 6 | 2 | 6 | 3.5 | NCc1ncoc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 146970182 | 196865 | 2 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 522 | 17 | 7 | 6 | 2.5 | N=C(N)NCCC[C@H](NCc1ccccn1)C(=O)NCc1ccc(CNCCCNC2CCCCC2)cc1 | 10.1016/j.ejmech.2022.114150 | ||
| CHEMBL5172755 | 196865 | 2 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 522 | 17 | 7 | 6 | 2.5 | N=C(N)NCCC[C@H](NCc1ccccn1)C(=O)NCc1ccc(CNCCCNC2CCCCC2)cc1 | 10.1016/j.ejmech.2022.114150 | ||
| 138501436 | 188526 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 391 | 4 | 0 | 7 | 2.4 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)c(C#N)c(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4777386 | 188526 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 391 | 4 | 0 | 7 | 2.4 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)c(C#N)c(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| 11565518 | 96659 | 89 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 290 | 6 | 2 | 4 | 3.7 | c1ccc(NCc2ccc(CNc3ccccn3)cc2)nc1 | 10.1021/jm100786g | ||
| CHEMBL237830 | 96659 | 89 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 290 | 6 | 2 | 4 | 3.7 | c1ccc(NCc2ccc(CNc3ccccn3)cc2)nc1 | 10.1021/jm100786g | ||
| 137655938 | 165763 | 0 | None | 64 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 362 | 6 | 2 | 4 | 3.0 | NC/C=C\CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4096305 | 165763 | 0 | None | 64 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 362 | 6 | 2 | 4 | 3.0 | NC/C=C\CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| 21985038 | 63669 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 426 | 7 | 3 | 5 | 4.0 | NCc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c(CN)c1 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644073 | 63669 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 426 | 7 | 3 | 5 | 4.0 | NCc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c(CN)c1 | 10.1016/j.bmcl.2010.11.023 | ||
| 59176527 | 158798 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 4.7 | Cn1c2ccccc2c2ccnc(CN(CCCCN)C3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3966991 | 158798 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 4.7 | Cn1c2ccccc2c2ccnc(CN(CCCCN)C3CCCc4cccnc43)c21 | nan | ||
| CHEMBL2372983 | 217110 | 0 | None | -32 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| 146398849 | 191718 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 417 | 4 | 2 | 5 | 2.8 | CN(C[C@H]1Cc2c(cccc2N2C[C@@H]3CNC[C@@H]3C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL4853570 | 191718 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 417 | 4 | 2 | 5 | 2.8 | CN(C[C@H]1Cc2c(cccc2N2C[C@@H]3CNC[C@@H]3C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| 146398367 | 193312 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 419 | 5 | 1 | 5 | 3.2 | CN(C[C@H]1Cc2c(cccc2N2CC[C@@H](N(C)C)C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL4877757 | 193312 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 419 | 5 | 1 | 5 | 3.2 | CN(C[C@H]1Cc2c(cccc2N2CC[C@@H](N(C)C)C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| 146398374 | 192342 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 419 | 5 | 1 | 5 | 3.2 | CN(C)[C@H]1CCN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)C1 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL4863276 | 192342 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 419 | 5 | 1 | 5 | 3.2 | CN(C)[C@H]1CCN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)C1 | 10.1021/acsmedchemlett.1c00449 | ||
| 59176443 | 149517 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 4.7 | NCCCCN(Cc1cc2c(cn1)[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3892436 | 149517 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 4.7 | NCCCCN(Cc1cc2c(cn1)[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| 145961199 | 169141 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 326 | 5 | 1 | 6 | 2.8 | CSc1nnc(-c2ccc(CNC(=O)c3ccccc3)nc2)o1 | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4165124 | 169141 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 326 | 5 | 1 | 6 | 2.8 | CSc1nnc(-c2ccc(CNC(=O)c3ccccc3)nc2)o1 | 10.1016/j.ejmech.2017.08.027 | ||
| 155523400 | 177529 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1cccc(CNCC2CCN(Cc3ccccc3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4452433 | 177529 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1cccc(CNCC2CCN(Cc3ccccc3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| 56750906 | 129775 | 6 | None | 2 | 2 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 332 | 5 | 1 | 3 | 3.8 | c1ccc(Cc2cn[nH]c2C2CCN(Cc3ccncc3)CC2)cc1 | 10.1021/acsmedchemlett.5b00036 | ||
| CHEMBL3608763 | 129775 | 6 | None | 2 | 2 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 332 | 5 | 1 | 3 | 3.8 | c1ccc(Cc2cn[nH]c2C2CCN(Cc3ccncc3)CC2)cc1 | 10.1021/acsmedchemlett.5b00036 | ||
| 59176363 | 151471 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 399 | 6 | 1 | 5 | 4.4 | CN(Cc1nccc2c3ccccc3n(CCCN)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3908514 | 151471 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 399 | 6 | 1 | 5 | 4.4 | CN(Cc1nccc2c3ccccc3n(CCCN)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 11176403 | 8874 | 1 | None | 1 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| 2900 | 8874 | 1 | None | 1 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| CHEMBL452864 | 8874 | 1 | None | 1 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| 145956817 | 169027 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 378 | 7 | 2 | 4 | 3.5 | Cc1cnc2c(c1)CCC[C@@H]2N(CCCCN)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4163573 | 169027 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 378 | 7 | 2 | 4 | 3.5 | Cc1cnc2c(c1)CCC[C@@H]2N(CCCCN)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 10126019 | 14500 | 20 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1088913 | 14500 | 20 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 21985074 | 63670 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 427 | 7 | 3 | 5 | 4.0 | NCc1cc(CO)ccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644074 | 63670 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 427 | 7 | 3 | 5 | 4.0 | NCc1cc(CO)ccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 59176432 | 161043 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 443 | 9 | 2 | 6 | 4.2 | NCCCCN(Cc1nccc2c3ccccc3n(CCO)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3986397 | 161043 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 443 | 9 | 2 | 6 | 4.2 | NCCCCN(Cc1nccc2c3ccccc3n(CCO)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 146398910 | 193122 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 431 | 4 | 1 | 5 | 3.2 | CN(C[C@H]1Cc2c(cccc2N2C[C@@H]3CCN(C)[C@@H]3C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL4875030 | 193122 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 431 | 4 | 1 | 5 | 3.2 | CN(C[C@H]1Cc2c(cccc2N2C[C@@H]3CCN(C)[C@@H]3C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| 59176435 | 155168 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 539 | 10 | 3 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)NC3CCNCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3937507 | 155168 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 539 | 10 | 3 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)NC3CCNCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 71455186 | 91200 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 414 | 12 | 2 | 4 | 4.4 | C[C@H]1CCCCN1CCCNCc1ccc(CNCCCN2CCCC[C@@H]2C)cc1 | 10.1021/jm300862u | ||
| CHEMBL2170443 | 91200 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 414 | 12 | 2 | 4 | 4.4 | C[C@H]1CCCCN1CCCNCc1ccc(CNCCCN2CCCC[C@@H]2C)cc1 | 10.1021/jm300862u | ||
| CHEMBL2219950 | 91200 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 414 | 12 | 2 | 4 | 4.4 | C[C@H]1CCCCN1CCCNCc1ccc(CNCCCN2CCCC[C@@H]2C)cc1 | 10.1021/jm300862u | ||
| 53325442 | 65203 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 3.8 | CC(c1ccccn1)N(CCCCN)Cc1ncccc1C(F)(F)F | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682988 | 65203 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 3.8 | CC(c1ccccn1)N(CCCCN)Cc1ncccc1C(F)(F)F | 10.1016/j.bmcl.2011.01.021 | ||
| 59176375 | 151764 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 512 | 9 | 2 | 7 | 3.8 | O=C(O)Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3910841 | 151764 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 512 | 9 | 2 | 7 | 3.8 | O=C(O)Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 135314388 | 164163 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 412 | 6 | 2 | 4 | 4.1 | NCc1ccc(CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)cc1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4078260 | 164163 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 412 | 6 | 2 | 4 | 4.1 | NCc1ccc(CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)cc1 | 10.1021/acs.jmedchem.7b01420 | ||
| 145949156 | 169491 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 419 | 7 | 2 | 5 | 2.8 | c1ccc2c(c1)CN[C@H](CN(CCCN1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4170857 | 169491 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 419 | 7 | 2 | 5 | 2.8 | c1ccc2c(c1)CN[C@H](CN(CCCN1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| 59176619 | 167688 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 4.7 | NCCCCN(Cc1cc2c(cn1)[nH]c1ccccc12)[C@@H]1CCCc2cccnc21 | nan | ||
| CHEMBL4115277 | 167688 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 4.7 | NCCCCN(Cc1cc2c(cn1)[nH]c1ccccc12)[C@@H]1CCCc2cccnc21 | nan | ||
| 21985008 | 15015 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 397 | 6 | 2 | 4 | 4.5 | NCc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)cc1 | 10.1021/jm100073m | ||
| CHEMBL1092324 | 15015 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 397 | 6 | 2 | 4 | 4.5 | NCc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)cc1 | 10.1021/jm100073m | ||
| 135313965 | 169571 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 421 | 7 | 1 | 6 | 3.9 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1nc2ccccc2s1 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4172234 | 169571 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 421 | 7 | 1 | 6 | 3.9 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1nc2ccccc2s1 | 10.1021/acsmedchemlett.8b00030 | ||
| 53325426 | 63681 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 387 | 6 | 2 | 5 | 4.1 | NCc1ccoc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644088 | 63681 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 387 | 6 | 2 | 5 | 4.1 | NCc1ccoc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 59176381 | 154093 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 526 | 9 | 1 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCOCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3929073 | 154093 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 526 | 9 | 1 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCOCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm1012374 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm1012374 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm1012374 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm1012374 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm1012374 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1021/jm1012374 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1021/jm1012374 | ||
| CHEMBL2372993 | 217115 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| 145953887 | 169347 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 386 | 6 | 2 | 8 | 3.1 | CSc1nnc(-c2ccc(CNC(=O)Nc3ccc([N+](=O)[O-])cc3)nc2)o1 | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4168547 | 169347 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 386 | 6 | 2 | 8 | 3.1 | CSc1nnc(-c2ccc(CNC(=O)Nc3ccc([N+](=O)[O-])cc3)nc2)o1 | 10.1016/j.ejmech.2017.08.027 | ||
| 59176391 | 151438 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 490 | 9 | 1 | 6 | 5.6 | NCCCCN(Cc1nccc2c3ccccc3n(Cc3ccncc3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3908253 | 151438 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 490 | 9 | 1 | 6 | 5.6 | NCCCCN(Cc1nccc2c3ccccc3n(Cc3ccncc3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 122192917 | 130671 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 317 | 7 | 3 | 5 | 1.1 | NCCCCN(C[C@@H]1CNCCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627789 | 130671 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 317 | 7 | 3 | 5 | 1.1 | NCCCCN(C[C@@H]1CNCCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 59176500 | 150722 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 554 | 9 | 1 | 7 | 4.8 | C[C@H]1CN(C(=O)Cn2c3ccccc3c3ccnc(CN(CCCCN)[C@H]4CCCc5cccnc54)c32)C[C@@H](C)O1 | nan | ||
| CHEMBL3902352 | 150722 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 554 | 9 | 1 | 7 | 4.8 | C[C@H]1CN(C(=O)Cn2c3ccccc3c3ccnc(CN(CCCCN)[C@H]4CCCc5cccnc54)c32)C[C@@H](C)O1 | nan | ||
| 59176411 | 151485 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 580 | 9 | 1 | 7 | 5.1 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCC3CCNCC3)[C@H]3CCCc4cccnc43)c21)N1CCOCC1 | nan | ||
| CHEMBL3908632 | 151485 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 580 | 9 | 1 | 7 | 5.1 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCC3CCNCC3)[C@H]3CCCc4cccnc43)c21)N1CCOCC1 | nan | ||
| 145959844 | 169131 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 433 | 7 | 1 | 5 | 3.1 | CN1CCN(CCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4165032 | 169131 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 433 | 7 | 1 | 5 | 3.1 | CN1CCN(CCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.8b00030 | ||
| 10146 | 8051 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 10.1016/j.ejmech.2018.10.060 | ||
| 137321154 | 8051 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4596188 | 8051 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 10.1016/j.ejmech.2018.10.060 | ||
| 21984997 | 63672 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 441 | 7 | 3 | 5 | 4.2 | NCc1cc(C(=O)O)ccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644076 | 63672 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 441 | 7 | 3 | 5 | 4.2 | NCc1cc(C(=O)O)ccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 72535470 | 153018 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 539 | 10 | 3 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)NC3CCNCC3)c12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3920438 | 153018 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 539 | 10 | 3 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)NC3CCNCC3)c12)C1CCCc2cccnc21 | nan | ||
| 59176401 | 153836 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 566 | 7 | 1 | 7 | 4.8 | N[C@H]1CC[C@@H](CN(Cc2nccc3c4ccccc4n(CC(=O)N4CCOCC4)c23)[C@H]2CCCc3cccnc32)CC1 | nan | ||
| CHEMBL3927015 | 153836 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 566 | 7 | 1 | 7 | 4.8 | N[C@H]1CC[C@@H](CN(Cc2nccc3c4ccccc4n(CC(=O)N4CCOCC4)c23)[C@H]2CCCc3cccnc32)CC1 | nan | ||
| 142416702 | 168896 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 356 | 8 | 2 | 4 | 2.8 | Cc1cc(F)cnc1CN(CCCCN)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4161409 | 168896 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 356 | 8 | 2 | 4 | 2.8 | Cc1cc(F)cnc1CN(CCCCN)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 53326308 | 65160 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 326 | 7 | 2 | 5 | 2.8 | NCCCCN(Cc1ncccc1O)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682862 | 65160 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 326 | 7 | 2 | 5 | 2.8 | NCCCCN(Cc1ncccc1O)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| 137641749 | 164841 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 362 | 6 | 2 | 4 | 3.0 | NC/C=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4086147 | 164841 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 362 | 6 | 2 | 4 | 3.0 | NC/C=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.7b01420 | ||
| 25178144 | 183637 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 430 | 4 | 1 | 5 | 5.1 | C1=C(CS/C(=N\C2CCCCC2)NC2C3CC4CC(C3)CC2C4)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL461359 | 183637 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 430 | 4 | 1 | 5 | 5.1 | C1=C(CS/C(=N\C2CCCCC2)NC2C3CC4CC(C3)CC2C4)N2CCN=C2S1 | 10.1021/jm801065q | ||
| 10126019 | 14500 | 20 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL1088913 | 14500 | 20 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.ejmech.2017.08.027 | ||
| 145956824 | 169040 | 0 | None | 1412 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 376 | 6 | 2 | 4 | 3.1 | NCC1CC1CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4163770 | 169040 | 0 | None | 1412 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 376 | 6 | 2 | 4 | 3.1 | NCC1CC1CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| 138501429 | 189291 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 394 | 5 | 0 | 6 | 3.4 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)cc(N2CCC(N(C)C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4787045 | 189291 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 394 | 5 | 0 | 6 | 3.4 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)cc(N2CCC(N(C)C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| 53326939 | 63685 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 389 | 5 | 2 | 5 | 4.6 | NCc1cscc1N(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644095 | 63685 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 389 | 5 | 2 | 5 | 4.6 | NCc1cscc1N(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 44242668 | 150920 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 511 | 10 | 1 | 6 | 6.0 | NCCCCN(Cc1nccc2c3ccccc3n(CCC3CCOCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3903887 | 150920 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 511 | 10 | 1 | 6 | 6.0 | NCCCCN(Cc1nccc2c3ccccc3n(CCC3CCOCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 146399128 | 191968 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 433 | 5 | 1 | 5 | 3.6 | CN1CCC(N(C)c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)CC1 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL4857452 | 191968 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 433 | 5 | 1 | 5 | 3.6 | CN1CCC(N(C)c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)CC1 | 10.1021/acsmedchemlett.1c00449 | ||
| 145957553 | 169048 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 419 | 5 | 1 | 5 | 3.2 | CCN1CCN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)CC1 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4163874 | 169048 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 419 | 5 | 1 | 5 | 3.2 | CCN1CCN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)CC1 | 10.1021/acs.jmedchem.8b00450 | ||
| 137641749 | 164841 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 362 | 6 | 2 | 4 | 3.0 | NC/C=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4086147 | 164841 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 362 | 6 | 2 | 4 | 3.0 | NC/C=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| 122192918 | 130672 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 393 | 8 | 2 | 5 | 3.0 | NCCCCN(CC1CN(c2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627790 | 130672 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 393 | 8 | 2 | 5 | 3.0 | NCCCCN(CC1CN(c2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 135314386 | 164574 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 503 | 9 | 2 | 5 | 5.4 | c1ccc2c(c1)CN[C@@H](CN(Cc1ccc(CNCc3ccncc3)cc1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4083122 | 164574 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 503 | 9 | 2 | 5 | 5.4 | c1ccc2c(c1)CN[C@@H](CN(Cc1ccc(CNCc3ccncc3)cc1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| 70924203 | 167601 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 4.7 | NCCCCN(Cc1nccc2c1[nH]c1ccccc12)[C@@H]1CCCc2cccnc21 | nan | ||
| CHEMBL4114592 | 167601 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 4.7 | NCCCCN(Cc1nccc2c1[nH]c1ccccc12)[C@@H]1CCCc2cccnc21 | nan | ||
| 59176375 | 151764 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 512 | 9 | 2 | 7 | 3.8 | O=C(O)Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3910841 | 151764 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 512 | 9 | 2 | 7 | 3.8 | O=C(O)Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 10149770 | 15164 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 321 | 5 | 2 | 4 | 2.8 | NCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1093302 | 15164 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 321 | 5 | 2 | 4 | 2.8 | NCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 59176448 | 160196 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 655 | 11 | 1 | 8 | 5.0 | O=C1CN(CCCN(Cc2nccc3c4ccccc4n(CCCN4C(=O)c5ccccc5C4=O)c23)[C@H]2CCCc3cccnc32)CCN1 | nan | ||
| CHEMBL3978984 | 160196 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 655 | 11 | 1 | 8 | 5.0 | O=C1CN(CCCN(Cc2nccc3c4ccccc4n(CCCN4C(=O)c5ccccc5C4=O)c23)[C@H]2CCCc3cccnc32)CCN1 | nan | ||
| 59176417 | 153365 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 617 | 12 | 1 | 8 | 5.3 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCCNCc3cccnc3)[C@H]3CCCc4cccnc43)c21)N1CCOCC1 | nan | ||
| CHEMBL3923061 | 153365 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 617 | 12 | 1 | 8 | 5.3 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCCNCc3cccnc3)[C@H]3CCCc4cccnc43)c21)N1CCOCC1 | nan | ||
| 59176387 | 149350 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 508 | 9 | 1 | 6 | 5.2 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1nccc2c3ccccc3n(CC3CC3)c12 | nan | ||
| CHEMBL3891093 | 149350 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 508 | 9 | 1 | 6 | 5.2 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1nccc2c3ccccc3n(CC3CC3)c12 | nan | ||
| 145956312 | 169477 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 433 | 4 | 1 | 5 | 3.6 | C[C@H]1CN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)C[C@@H](C)N1C | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4170542 | 169477 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 433 | 4 | 1 | 5 | 3.6 | C[C@H]1CN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)C[C@@H](C)N1C | 10.1021/acs.jmedchem.8b00450 | ||
| 145953040 | 169392 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 405 | 5 | 2 | 5 | 2.9 | CCN(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4169280 | 169392 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 405 | 5 | 2 | 5 | 2.9 | CCN(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 72546066 | 110617 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 406 | 8 | 1 | 4 | 4.3 | CC(C)N1Cc2ccccc2C[C@@H]1CN(CCCCN)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091694 | 110617 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 406 | 8 | 1 | 4 | 4.3 | CC(C)N1Cc2ccccc2C[C@@H]1CN(CCCCN)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 9887073 | 14487 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 397 | 6 | 2 | 4 | 4.5 | NCc1cccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c1 | 10.1021/jm100073m | ||
| CHEMBL1088867 | 14487 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 397 | 6 | 2 | 4 | 4.5 | NCc1cccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c1 | 10.1021/jm100073m | ||
| 59176474 | 151627 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 385 | 5 | 1 | 5 | 4.1 | CN(Cc1nccc2c3ccccc3n(CCN)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3909728 | 151627 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 385 | 5 | 1 | 5 | 4.1 | CN(Cc1nccc2c3ccccc3n(CCN)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 44242663 | 155336 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 4.7 | NCCCCN(Cc1nccc2c1[nH]c1ccccc12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3938805 | 155336 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 4.7 | NCCCCN(Cc1nccc2c1[nH]c1ccccc12)C1CCCc2cccnc21 | nan | ||
| 135313899 | 165032 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 530 | 8 | 2 | 4 | 6.3 | FC1(F)CCC(NCc2ccc(CN(C[C@H]3Cc4ccccc4CN3)[C@H]3CCCc4cccnc43)cc2)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4088588 | 165032 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 530 | 8 | 2 | 4 | 6.3 | FC1(F)CCC(NCc2ccc(CN(C[C@H]3Cc4ccccc4CN3)[C@H]3CCCc4cccnc43)cc2)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 70924224 | 154437 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 413 | 7 | 2 | 4 | 4.3 | NC(=O)CCCN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3931671 | 154437 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 413 | 7 | 2 | 4 | 4.3 | NC(=O)CCCN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| 145973345 | 169789 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 403 | 4 | 2 | 5 | 2.7 | CN(C[C@H]1Cc2c(cccc2N2C[C@@H]3C[C@H]2CN3)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4175596 | 169789 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 403 | 4 | 2 | 5 | 2.7 | CN(C[C@H]1Cc2c(cccc2N2C[C@@H]3C[C@H]2CN3)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 21985015 | 63674 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 440 | 7 | 3 | 5 | 3.6 | NCc1cc(C(N)=O)ccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644078 | 63674 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 440 | 7 | 3 | 5 | 3.6 | NCc1cc(C(N)=O)ccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 59176504 | 150897 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 525 | 11 | 2 | 7 | 4.5 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN3CCNCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3903672 | 150897 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 525 | 11 | 2 | 7 | 4.5 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN3CCNCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 59176542 | 157794 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 485 | 10 | 1 | 7 | 4.8 | CCOC(=O)Cn1c2ccccc2c2ccnc(CN(CCCCN)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3958465 | 157794 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 485 | 10 | 1 | 7 | 4.8 | CCOC(=O)Cn1c2ccccc2c2ccnc(CN(CCCCN)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 137638242 | 163634 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 455 | 10 | 2 | 5 | 4.4 | c1cncc(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)c1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4071612 | 163634 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 455 | 10 | 2 | 5 | 4.4 | c1cncc(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)c1 | 10.1021/acs.jmedchem.7b01420 | ||
| 133081963 | 7885 | 0 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 446 | 8 | 2 | 5 | 3.8 | O1CCC(CC1)NC/C=C/CN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acs.jmedchem.7b01420 | ||
| 9883 | 7885 | 0 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 446 | 8 | 2 | 5 | 3.8 | O1CCC(CC1)NC/C=C/CN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4075205 | 7885 | 0 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 446 | 8 | 2 | 5 | 3.8 | O1CCC(CC1)NC/C=C/CN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acs.jmedchem.7b01420 | ||
| 145959814 | 169109 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 404 | 6 | 2 | 4 | 3.9 | c1ccc2c(c1)CN[C@@H](CN(CCC1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4164702 | 169109 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 404 | 6 | 2 | 4 | 3.9 | c1ccc2c(c1)CN[C@@H](CN(CCC1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| 59176639 | 158467 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 544 | 9 | 1 | 6 | 5.8 | c1ccc(Cn2c3ccccc3c3ccnc(CN(CCCN4CCNCC4)[C@H]4CCCc5cccnc54)c32)cc1 | nan | ||
| CHEMBL3964188 | 158467 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 544 | 9 | 1 | 6 | 5.8 | c1ccc(Cn2c3ccccc3c3ccnc(CN(CCCN4CCNCC4)[C@H]4CCCc5cccnc54)c32)cc1 | nan | ||
| 145974080 | 169843 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 435 | 7 | 2 | 6 | 2.5 | COCCN(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4176403 | 169843 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 435 | 7 | 2 | 6 | 2.5 | COCCN(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 137646125 | 164727 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 460 | 10 | 2 | 4 | 5.4 | c1ccc2c(c1)CN[C@@H](CN(CCCCNCC1CCCCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4084652 | 164727 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 460 | 10 | 2 | 4 | 5.4 | c1ccc2c(c1)CN[C@@H](CN(CCCCNCC1CCCCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| 145949343 | 169711 | 0 | None | 371 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 404 | 6 | 2 | 4 | 3.9 | c1ccc2c(c1)CN[C@@H](CN(CC[C@H]1CCCNC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4174290 | 169711 | 0 | None | 371 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 404 | 6 | 2 | 4 | 3.9 | c1ccc2c(c1)CN[C@@H](CN(CC[C@H]1CCCNC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| 59176504 | 150897 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 525 | 11 | 2 | 7 | 4.5 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN3CCNCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3903672 | 150897 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 525 | 11 | 2 | 7 | 4.5 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN3CCNCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 135314048 | 169865 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 405 | 4 | 2 | 5 | 2.8 | Cc1cnc2c(c1)CCC[C@@H]2N(C)C[C@H]1Cc2c(cccc2N2CCNCC2)CN1 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4176701 | 169865 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 405 | 4 | 2 | 5 | 2.8 | Cc1cnc2c(c1)CCC[C@@H]2N(C)C[C@H]1Cc2c(cccc2N2CCNCC2)CN1 | 10.1021/acs.jmedchem.8b00450 | ||
| 145950510 | 169542 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 433 | 5 | 1 | 5 | 3.6 | CC(C)N1CCN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)CC1 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4171755 | 169542 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 433 | 5 | 1 | 5 | 3.6 | CC(C)N1CCN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)CC1 | 10.1021/acs.jmedchem.8b00450 | ||
| 10172242 | 14637 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 347 | 6 | 2 | 4 | 3.4 | NC/C=C/CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1089845 | 14637 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 347 | 6 | 2 | 4 | 3.4 | NC/C=C/CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 21985119 | 63679 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 398 | 6 | 2 | 5 | 3.9 | NCc1ccncc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644083 | 63679 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 398 | 6 | 2 | 5 | 3.9 | NCc1ccncc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 145958528 | 169033 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 404 | 6 | 2 | 4 | 3.9 | c1ccc2c(c1)CN[C@@H](CN(CC[C@@H]1CCCNC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4163611 | 169033 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 404 | 6 | 2 | 4 | 3.9 | c1ccc2c(c1)CN[C@@H](CN(CC[C@@H]1CCCNC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| 53326307 | 65159 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 354 | 9 | 1 | 5 | 3.2 | COCc1cccc(CN(CCCCN)C2CCCc3cccnc32)n1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682861 | 65159 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 354 | 9 | 1 | 5 | 3.2 | COCc1cccc(CN(CCCCN)C2CCCc3cccnc32)n1 | 10.1016/j.bmcl.2011.01.021 | ||
| 135313955 | 169184 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 364 | 9 | 2 | 4 | 3.2 | NCCCCN(Cc1ncccc1C1CC1)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4165906 | 169184 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 364 | 9 | 2 | 4 | 3.2 | NCCCCN(Cc1ncccc1C1CC1)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 59176526 | 150572 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 543 | 8 | 0 | 6 | 6.2 | CCN(Cc1nccc2c3ccccc3n(CCCN3C(=O)c4ccccc4C3=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3901111 | 150572 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 543 | 8 | 0 | 6 | 6.2 | CCN(Cc1nccc2c3ccccc3n(CCCN3C(=O)c4ccccc4C3=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 44242735 | 156009 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 467 | 8 | 3 | 6 | 4.3 | c1cnc2c(c1)CCCC2N(CCCCNC1=NCCN1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| CHEMBL3944213 | 156009 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 467 | 8 | 3 | 6 | 4.3 | c1cnc2c(c1)CCCC2N(CCCCNC1=NCCN1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| 146398749 | 191393 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 405 | 5 | 3 | 5 | 3.3 | CN(C[C@@H]1Cc2c(cccc2NC2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL4849088 | 191393 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 405 | 5 | 3 | 5 | 3.3 | CN(C[C@@H]1Cc2c(cccc2NC2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| 137654290 | 165581 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 510 | 9 | 2 | 4 | 6.1 | CC(C)(CCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)CNC1CCC(F)(F)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4094400 | 165581 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 510 | 9 | 2 | 4 | 6.1 | CC(C)(CCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)CNC1CCC(F)(F)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 137658901 | 166214 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 496 | 10 | 2 | 4 | 5.7 | FC1(F)CCC(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4101106 | 166214 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 496 | 10 | 2 | 4 | 5.7 | FC1(F)CCC(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 70924220 | 150626 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 427 | 9 | 2 | 4 | 5.4 | CCNCCCCN(Cc1nccc2c1[nH]c1ccccc12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3901600 | 150626 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 427 | 9 | 2 | 4 | 5.4 | CCNCCCCN(Cc1nccc2c1[nH]c1ccccc12)C1CCCc2cccnc21 | nan | ||
| 145952721 | 169249 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 419 | 7 | 2 | 5 | 2.8 | c1ccc2c(c1)CN[C@@H](CN(CCCN1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4167058 | 169249 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 419 | 7 | 2 | 5 | 2.8 | c1ccc2c(c1)CN[C@@H](CN(CCCN1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| 145949486 | 169615 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 415 | 7 | 1 | 5 | 3.8 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1cc2ccccc2cn1 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4172802 | 169615 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 415 | 7 | 1 | 5 | 3.8 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1cc2ccccc2cn1 | 10.1021/acsmedchemlett.8b00030 | ||
| 137639251 | 163559 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 510 | 10 | 2 | 6 | 3.7 | O=S1(=O)CCC(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4070843 | 163559 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 510 | 10 | 2 | 6 | 3.7 | O=S1(=O)CCC(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 59176416 | 159474 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 456 | 9 | 2 | 6 | 3.7 | NCCCCN(Cc1nccc2c3ccccc3n(CC(N)=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3972873 | 159474 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 456 | 9 | 2 | 6 | 3.7 | NCCCCN(Cc1nccc2c3ccccc3n(CC(N)=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 145954878 | 169437 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 468 | 5 | 1 | 6 | 3.8 | CN(C[C@H]1Cc2c(cccc2N2CCN(c3ccccn3)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4169875 | 169437 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 468 | 5 | 1 | 6 | 3.8 | CN(C[C@H]1Cc2c(cccc2N2CCN(c3ccccn3)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 142416740 | 169899 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 419 | 4 | 0 | 5 | 3.2 | CN1CCN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)N(C)C3)CC1 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4177338 | 169899 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 419 | 4 | 0 | 5 | 3.2 | CN1CCN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)N(C)C3)CC1 | 10.1021/acs.jmedchem.8b00450 | ||
| 145952601 | 169773 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 420 | 7 | 2 | 6 | 2.2 | c1cnc2c(c1)CN[C@@H](CN(CCCN1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4175350 | 169773 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 420 | 7 | 2 | 6 | 2.2 | c1cnc2c(c1)CN[C@@H](CN(CCCN1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| 135314132 | 168823 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 352 | 8 | 2 | 4 | 3.2 | Cc1ccc([C@H](C)N(CCCCN)C[C@H]2Cc3ccccc3CN2)nc1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4160208 | 168823 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 352 | 8 | 2 | 4 | 3.2 | Cc1ccc([C@H](C)N(CCCCN)C[C@H]2Cc3ccccc3CN2)nc1 | 10.1021/acsmedchemlett.7b00381 | ||
| 70924231 | 155638 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 441 | 8 | 2 | 4 | 4.9 | CC(=O)NCCCCN(Cc1nccc2c1[nH]c1ccccc12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3941363 | 155638 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 441 | 8 | 2 | 4 | 4.9 | CC(=O)NCCCCN(Cc1nccc2c1[nH]c1ccccc12)C1CCCc2cccnc21 | nan | ||
| 25178140 | 183521 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 364 | 4 | 1 | 5 | 4.2 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL460299 | 183521 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 364 | 4 | 1 | 5 | 4.2 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| 59176597 | 154786 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 545 | 9 | 1 | 7 | 5.2 | c1ccc(Cn2c3ccccc3c3ccnc(CN(CCCN4CCNCC4)[C@H]4CCCc5cccnc54)c32)nc1 | nan | ||
| CHEMBL3934356 | 154786 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 545 | 9 | 1 | 7 | 5.2 | c1ccc(Cn2c3ccccc3c3ccnc(CN(CCCN4CCNCC4)[C@H]4CCCc5cccnc54)c32)nc1 | nan | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 53322384 | 65152 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.4 | Cc1cccnc1CN(CCCCN)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682854 | 65152 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.4 | Cc1cccnc1CN(CCCCN)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| 53322799 | 65204 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 340 | 8 | 1 | 4 | 4.1 | CC(c1ccccn1)N(CCCCN)Cc1ncccc1C(C)(C)C | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682989 | 65204 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 340 | 8 | 1 | 4 | 4.1 | CC(c1ccccn1)N(CCCCN)Cc1ncccc1C(C)(C)C | 10.1016/j.bmcl.2011.01.021 | ||
| 122192923 | 130678 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 451 | 9 | 2 | 6 | 3.1 | NCCCCN(C[C@H]1CN(C(=O)OCc2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627799 | 130678 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 451 | 9 | 2 | 6 | 3.1 | NCCCCN(C[C@H]1CN(C(=O)OCc2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 70923321 | 149598 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 454 | 7 | 2 | 5 | 4.3 | c1cnc2c(c1)CCCC2N(CCCN1CCNCC1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| CHEMBL3893005 | 149598 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 454 | 7 | 2 | 5 | 4.3 | c1cnc2c(c1)CCCC2N(CCCN1CCNCC1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| 59176416 | 159474 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 456 | 9 | 2 | 6 | 3.7 | NCCCCN(Cc1nccc2c3ccccc3n(CC(N)=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3972873 | 159474 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 456 | 9 | 2 | 6 | 3.7 | NCCCCN(Cc1nccc2c3ccccc3n(CC(N)=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 146398747 | 193083 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 405 | 5 | 3 | 5 | 3.3 | CN(C[C@H]1Cc2c(cccc2NC2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL4874526 | 193083 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 405 | 5 | 3 | 5 | 3.3 | CN(C[C@H]1Cc2c(cccc2NC2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| 146398328 | 192275 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 431 | 4 | 1 | 5 | 3.2 | CN(C[C@H]1Cc2c(cccc2N2C[C@H]3CCN(C)[C@H]3C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL4862362 | 192275 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 431 | 4 | 1 | 5 | 3.2 | CN(C[C@H]1Cc2c(cccc2N2C[C@H]3CCN(C)[C@H]3C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| 76309931 | 110610 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 435 | 8 | 2 | 4 | 3.5 | CN(C)C(=O)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091686 | 110610 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 435 | 8 | 2 | 4 | 3.5 | CN(C)C(=O)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 142416884 | 168926 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 390 | 4 | 2 | 4 | 3.7 | N[C@H]1CC[C@@H](N(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4161850 | 168926 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 390 | 4 | 2 | 4 | 3.7 | N[C@H]1CC[C@@H](N(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.7b00406 | ||
| 142416914 | 169405 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | C/C(CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)=C(/F)CN | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4169450 | 169405 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | C/C(CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)=C(/F)CN | 10.1021/acsmedchemlett.7b00406 | ||
| 70924214 | 156968 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 454 | 5 | 2 | 5 | 3.4 | O=C(CN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21)N1CCNCC1 | nan | ||
| CHEMBL3951883 | 156968 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 454 | 5 | 2 | 5 | 3.4 | O=C(CN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21)N1CCNCC1 | nan | ||
| 25177630 | 65206 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 298 | 8 | 1 | 4 | 3.1 | Cc1cccc(CN(CCCCN)C(C)c2ccccn2)n1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682991 | 65206 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 298 | 8 | 1 | 4 | 3.1 | Cc1cccc(CN(CCCCN)C(C)c2ccccn2)n1 | 10.1016/j.bmcl.2011.01.021 | ||
| 135314469 | 162574 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 510 | 9 | 2 | 5 | 5.2 | c1ccc2c(c1)CN[C@@H](CN(Cc1ccc(CNCC3CCOCC3)cc1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4059622 | 162574 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 510 | 9 | 2 | 5 | 5.2 | c1ccc2c(c1)CN[C@@H](CN(Cc1ccc(CNCC3CCOCC3)cc1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| 135313764 | 169588 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 358 | 8 | 2 | 4 | 3.0 | NCCCCN(Cc1ncccc1Cl)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4172443 | 169588 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 358 | 8 | 2 | 4 | 3.0 | NCCCCN(Cc1ncccc1Cl)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 57345320 | 10604 | 9 | None | 34 | 7 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| 9882 | 10604 | 9 | None | 34 | 7 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| CHEMBL3091687 | 10604 | 9 | None | 34 | 7 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| 53321039 | 65157 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 338 | 7 | 1 | 4 | 3.7 | Cc1cnc(CN(CCCCN)C2CCCc3cccnc32)c(C)c1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682859 | 65157 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 338 | 7 | 1 | 4 | 3.7 | Cc1cnc(CN(CCCCN)C2CCCc3cccnc32)c(C)c1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL2372985 | 217111 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| 10286987 | 15011 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 363 | 8 | 2 | 4 | 3.8 | CNCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1092302 | 15011 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 363 | 8 | 2 | 4 | 3.8 | CNCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 57345321 | 130674 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 407 | 9 | 2 | 5 | 3.0 | NCCCCN(C[C@@H]1CN(Cc2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627792 | 130674 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 407 | 9 | 2 | 5 | 3.0 | NCCCCN(C[C@@H]1CN(Cc2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 145951410 | 169633 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 387 | 6 | 1 | 9 | 3.5 | CSc1nnc(-c2ccc(COC(=O)Nc3ccc([N+](=O)[O-])cc3)nc2)o1 | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4173028 | 169633 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 387 | 6 | 1 | 9 | 3.5 | CSc1nnc(-c2ccc(COC(=O)Nc3ccc([N+](=O)[O-])cc3)nc2)o1 | 10.1016/j.ejmech.2017.08.027 | ||
| 145948147 | 174521 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 236 | 3 | 1 | 6 | 1.6 | CSc1nnc(-c2ccc(CN)nc2C)o1 | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4176412 | 174521 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 236 | 3 | 1 | 6 | 1.6 | CSc1nnc(-c2ccc(CN)nc2C)o1 | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4302859 | 174521 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 236 | 3 | 1 | 6 | 1.6 | CSc1nnc(-c2ccc(CN)nc2C)o1 | 10.1016/j.ejmech.2017.08.027 | ||
| 70924193 | 158875 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 538 | 7 | 1 | 5 | 5.6 | CC(C)(C)C(=O)N1CCN(CCCN(Cc2nccc3c2[nH]c2ccccc23)C2CCCc3cccnc32)CC1 | nan | ||
| CHEMBL3967679 | 158875 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 538 | 7 | 1 | 5 | 5.6 | CC(C)(C)C(=O)N1CCN(CCCN(Cc2nccc3c2[nH]c2ccccc23)C2CCCc3cccnc32)CC1 | nan | ||
| 145949907 | 169623 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 421 | 6 | 3 | 6 | 1.9 | OCCN(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4172898 | 169623 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 421 | 6 | 3 | 6 | 1.9 | OCCN(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 70924201 | 157144 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 468 | 8 | 2 | 5 | 4.7 | c1cnc2c(c1)CCCC2N(CCCCN1CCNCC1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| CHEMBL3953260 | 157144 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 468 | 8 | 2 | 5 | 4.7 | c1cnc2c(c1)CCCC2N(CCCCN1CCNCC1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| 44241788 | 157775 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 359 | 8 | 2 | 4 | 3.9 | NCCCCN(Cc1ccccn1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| CHEMBL3958373 | 157775 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 359 | 8 | 2 | 4 | 3.9 | NCCCCN(Cc1ccccn1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| 155539331 | 179619 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 328 | 6 | 1 | 2 | 4.3 | Clc1ccccc1CN1CCC(CNCc2ccccc2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4514484 | 179619 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 328 | 6 | 1 | 2 | 4.3 | Clc1ccccc1CN1CCC(CNCc2ccccc2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 57343753 | 130675 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 421 | 8 | 2 | 5 | 2.6 | NCCCCN(C[C@H]1CN(C(=O)c2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627793 | 130675 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 421 | 8 | 2 | 5 | 2.6 | NCCCCN(C[C@H]1CN(C(=O)c2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 122192964 | 130680 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 457 | 9 | 2 | 6 | 2.2 | NCCCCN(C[C@H]1CN(S(=O)(=O)c2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627858 | 130680 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 457 | 9 | 2 | 6 | 2.2 | NCCCCN(C[C@H]1CN(S(=O)(=O)c2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 122192968 | 130684 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 491 | 9 | 2 | 6 | 2.8 | NCCCCN(C[C@H]1CN(S(=O)(=O)c2ccc(Cl)cc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627862 | 130684 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 491 | 9 | 2 | 6 | 2.8 | NCCCCN(C[C@H]1CN(S(=O)(=O)c2ccc(Cl)cc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 25178353 | 197677 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 434 | 4 | 1 | 5 | 6.1 | CC1(C)CN2C(CS/C(=N\C3CCCCCC3)NC3CCCCCC3)=CSC2=N1 | 10.1021/jm801065q | ||
| CHEMBL518501 | 197677 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 434 | 4 | 1 | 5 | 6.1 | CC1(C)CN2C(CS/C(=N\C3CCCCCC3)NC3CCCCCC3)=CSC2=N1 | 10.1021/jm801065q | ||
| 11718722 | 23428 | 13 | None | 1 | 4 | Mouse | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| CHEMBL1242210 | 23428 | 13 | None | 1 | 4 | Mouse | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| 134816893 | 174294 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4214960 | 174294 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4299893 | 174294 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 11718722 | 23428 | 13 | None | -1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| CHEMBL1242210 | 23428 | 13 | None | -1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| 138501462 | 189050 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 352 | 4 | 0 | 6 | 2.3 | Cc1nc(CN2CCC[C@H]2c2ccccn2)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4783831 | 189050 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 352 | 4 | 0 | 6 | 2.3 | Cc1nc(CN2CCC[C@H]2c2ccccn2)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| 138501427 | 189459 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 396 | 7 | 1 | 7 | 2.6 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)cc(NCCN2CCOCC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4789233 | 189459 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 396 | 7 | 1 | 7 | 2.6 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)cc(NCCN2CCOCC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| 145951236 | 169692 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 4 | 1 | 5 | 3.4 | CN(C[C@H]1Cc2c(cccc2N2CCN3CCC[C@H]3C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4173977 | 169692 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 4 | 1 | 5 | 3.4 | CN(C[C@H]1Cc2c(cccc2N2CCN3CCC[C@H]3C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 25177631 | 65207 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 312 | 8 | 1 | 4 | 3.4 | Cc1cnc(CN(CCCCN)C(C)c2ccccn2)c(C)c1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682992 | 65207 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 312 | 8 | 1 | 4 | 3.4 | Cc1cnc(CN(CCCCN)C(C)c2ccccn2)c(C)c1 | 10.1016/j.bmcl.2011.01.021 | ||
| 59176569 | 150887 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 457 | 10 | 1 | 6 | 4.8 | COCCn1c2ccccc2c2ccnc(CN(CCCCN)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3903597 | 150887 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 457 | 10 | 1 | 6 | 4.8 | COCCn1c2ccccc2c2ccnc(CN(CCCCN)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 59176436 | 156800 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 539 | 11 | 2 | 7 | 4.0 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN3CCNCC3=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3950388 | 156800 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 539 | 11 | 2 | 7 | 4.0 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN3CCNCC3=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 137637838 | 162870 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 454 | 10 | 2 | 4 | 5.0 | c1ccc(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)cc1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4062981 | 162870 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 454 | 10 | 2 | 4 | 5.0 | c1ccc(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)cc1 | 10.1021/acs.jmedchem.7b01420 | ||
| 145960247 | 169017 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 403 | 4 | 2 | 5 | 2.7 | CN(C[C@H]1Cc2c(cccc2N2C[C@H]3C[C@@H]2CN3)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4163467 | 169017 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 403 | 4 | 2 | 5 | 2.7 | CN(C[C@H]1Cc2c(cccc2N2C[C@H]3C[C@@H]2CN3)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 71590315 | 170730 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 380 | 4 | 3 | 3 | 4.0 | FC(F)(F)c1ccc(NC(=S)NCCc2ccc3c(n2)NCCC3)cc1 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL4207733 | 170730 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 380 | 4 | 3 | 3 | 4.0 | FC(F)(F)c1ccc(NC(=S)NCCc2ccc3c(n2)NCCC3)cc1 | 10.1016/j.ejmech.2018.02.043 | ||
| 70924240 | 152208 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 468 | 7 | 1 | 5 | 4.6 | CN1CCN(CCCN(Cc2nccc3c2[nH]c2ccccc23)[C@H]2CCCc3cccnc32)CC1 | nan | ||
| CHEMBL3914182 | 152208 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 468 | 7 | 1 | 5 | 4.6 | CN1CCN(CCCN(Cc2nccc3c2[nH]c2ccccc23)[C@H]2CCCc3cccnc32)CC1 | nan | ||
| 135313758 | 169621 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 338 | 8 | 2 | 4 | 2.6 | Cc1cccnc1CN(CCCCN)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4172866 | 169621 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 338 | 8 | 2 | 4 | 2.6 | Cc1cccnc1CN(CCCCN)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 21985109 | 63671 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 441 | 8 | 2 | 5 | 4.6 | COCc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c(CN)c1 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644075 | 63671 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 441 | 8 | 2 | 5 | 4.6 | COCc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c(CN)c1 | 10.1016/j.bmcl.2010.11.023 | ||
| 53321859 | 63682 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 387 | 6 | 2 | 5 | 4.1 | NCc1occc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644089 | 63682 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 387 | 6 | 2 | 5 | 4.1 | NCc1occc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 53323183 | 63684 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 398 | 6 | 2 | 5 | 3.9 | NCc1ncccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644094 | 63684 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 398 | 6 | 2 | 5 | 3.9 | NCc1ncccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 59176357 | 154900 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 456 | 10 | 2 | 6 | 4.6 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3935318 | 154900 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 456 | 10 | 2 | 6 | 4.6 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 59176456 | 158213 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 540 | 10 | 2 | 7 | 4.5 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)NC3CCOCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3961860 | 158213 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 540 | 10 | 2 | 7 | 4.5 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)NC3CCOCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 135314108 | 168911 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 379 | 5 | 2 | 5 | 2.3 | Cc1cnc(CN(C)C[C@H]2Cc3c(cccc3N3CCNCC3)CN2)c(C)c1 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4161589 | 168911 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 379 | 5 | 2 | 5 | 2.3 | Cc1cnc(CN(C)C[C@H]2Cc3c(cccc3N3CCNCC3)CN2)c(C)c1 | 10.1021/acs.jmedchem.8b00450 | ||
| 145959135 | 168833 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 405 | 7 | 3 | 4 | 2.7 | NC(=O)NC/C=C\CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4160401 | 168833 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 405 | 7 | 3 | 4 | 2.7 | NC(=O)NC/C=C\CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| 122192969 | 130685 | 0 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 436 | 8 | 3 | 5 | 3.0 | NCCCCN(C[C@H]1CN(C(=O)Nc2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627863 | 130685 | 0 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 436 | 8 | 3 | 5 | 3.0 | NCCCCN(C[C@H]1CN(C(=O)Nc2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 135314256 | 169379 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 342 | 8 | 2 | 4 | 2.5 | NCCCCN(Cc1ncccc1F)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4169064 | 169379 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 342 | 8 | 2 | 4 | 2.5 | NCCCCN(Cc1ncccc1F)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 59176517 | 157098 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 540 | 9 | 2 | 7 | 4.2 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCC(O)CC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3952929 | 157098 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 540 | 9 | 2 | 7 | 4.2 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCC(O)CC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 59176401 | 153916 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 566 | 7 | 1 | 7 | 4.8 | N[C@H]1CC[C@H](CN(Cc2nccc3c4ccccc4n(CC(=O)N4CCOCC4)c23)[C@H]2CCCc3cccnc32)CC1 | nan | ||
| CHEMBL3927684 | 153916 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 566 | 7 | 1 | 7 | 4.8 | N[C@H]1CC[C@H](CN(Cc2nccc3c4ccccc4n(CC(=O)N4CCOCC4)c23)[C@H]2CCCc3cccnc32)CC1 | nan | ||
| 59176576 | 152730 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 529 | 7 | 0 | 6 | 5.8 | CN(Cc1nccc2c3ccccc3n(CCCN3C(=O)c4ccccc4C3=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3918137 | 152730 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 529 | 7 | 0 | 6 | 5.8 | CN(Cc1nccc2c3ccccc3n(CCCN3C(=O)c4ccccc4C3=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 21984993 | 63666 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 415 | 6 | 2 | 4 | 4.6 | NCc1cc(F)ccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644070 | 63666 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 415 | 6 | 2 | 4 | 4.6 | NCc1cc(F)ccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 59176365 | 158245 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 457 | 9 | 2 | 6 | 4.3 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3962108 | 158245 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 457 | 9 | 2 | 6 | 4.3 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 59176638 | 159983 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 4.7 | Cn1c2ccccc2c2ccnc(CN(CCCCN)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3977215 | 159983 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 4.7 | Cn1c2ccccc2c2ccnc(CN(CCCCN)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 137652982 | 165407 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 455 | 10 | 2 | 5 | 4.4 | c1ccc2c(c1)CN[C@@H](CN(CCCCNCc1ccncc1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4092405 | 165407 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 455 | 10 | 2 | 5 | 4.4 | c1ccc2c(c1)CN[C@@H](CN(CCCCNCc1ccncc1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL2372994 | 217116 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| 44563689 | 196605 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 388 | 5 | 1 | 5 | 4.0 | c1ccc(CN/C(=N/C2CCCCC2)SCC2CSC3=NCCN32)cc1 | 10.1021/jm801065q | ||
| CHEMBL516480 | 196605 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 388 | 5 | 1 | 5 | 4.0 | c1ccc(CN/C(=N/C2CCCCC2)SCC2CSC3=NCCN32)cc1 | 10.1021/jm801065q | ||
| 25177628 | 65201 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 298 | 8 | 1 | 4 | 3.1 | Cc1cccnc1CN(CCCCN)C(C)c1ccccn1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682986 | 65201 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 298 | 8 | 1 | 4 | 3.1 | Cc1cccnc1CN(CCCCN)C(C)c1ccccn1 | 10.1016/j.bmcl.2011.01.021 | ||
| 122192965 | 130681 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 457 | 9 | 2 | 6 | 2.2 | NCCCCN(C[C@@H]1CN(S(=O)(=O)c2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627859 | 130681 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 457 | 9 | 2 | 6 | 2.2 | NCCCCN(C[C@@H]1CN(S(=O)(=O)c2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 145953177 | 169271 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 431 | 5 | 1 | 5 | 3.4 | CN(C[C@H]1Cc2c(cccc2N2CCN(C3CC3)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4167324 | 169271 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 431 | 5 | 1 | 5 | 3.4 | CN(C[C@H]1Cc2c(cccc2N2CCN(C3CC3)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL2373001 | 217123 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| 145954567 | 169285 | 0 | None | 100 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 416 | 6 | 2 | 4 | 4.3 | NCC1=C(CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CCCC1 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4167521 | 169285 | 0 | None | 100 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 416 | 6 | 2 | 4 | 4.3 | NCC1=C(CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CCCC1 | 10.1021/acsmedchemlett.7b00406 | ||
| 135313931 | 169768 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 324 | 8 | 2 | 4 | 2.3 | NCCCCN(Cc1ccccn1)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4175319 | 169768 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 324 | 8 | 2 | 4 | 2.3 | NCCCCN(Cc1ccccn1)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 57345322 | 130673 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 407 | 9 | 2 | 5 | 3.0 | NCCCCN(C[C@H]1CN(Cc2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627791 | 130673 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 407 | 9 | 2 | 5 | 3.0 | NCCCCN(C[C@H]1CN(Cc2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 146970182 | 196865 | 2 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 522 | 17 | 7 | 6 | 2.5 | N=C(N)NCCC[C@H](NCc1ccccn1)C(=O)NCc1ccc(CNCCCNC2CCCCC2)cc1 | 10.1016/j.ejmech.2022.114150 | ||
| CHEMBL5172755 | 196865 | 2 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 522 | 17 | 7 | 6 | 2.5 | N=C(N)NCCC[C@H](NCc1ccccn1)C(=O)NCc1ccc(CNCCCNC2CCCCC2)cc1 | 10.1016/j.ejmech.2022.114150 | ||
| 135313960 | 169105 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 352 | 8 | 2 | 4 | 3.2 | Cc1cccnc1[C@H](C)N(CCCCN)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4164685 | 169105 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 352 | 8 | 2 | 4 | 3.2 | Cc1cccnc1[C@H](C)N(CCCCN)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 70965023 | 151274 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 567 | 10 | 1 | 8 | 4.1 | c1cnc2c(c1)CCCC2N(CCCN1CCNCC1)Cc1nccc2c3ccccc3n(CCN3CCOCC3)c12 | nan | ||
| CHEMBL3906863 | 151274 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 567 | 10 | 1 | 8 | 4.1 | c1cnc2c(c1)CCCC2N(CCCN1CCNCC1)Cc1nccc2c3ccccc3n(CCN3CCOCC3)c12 | nan | ||
| 59176516 | 160403 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 567 | 10 | 1 | 8 | 4.1 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1nccc2c3ccccc3n(CCN3CCOCC3)c12 | nan | ||
| CHEMBL3980819 | 160403 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 567 | 10 | 1 | 8 | 4.1 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1nccc2c3ccccc3n(CCN3CCOCC3)c12 | nan | ||
| 135314141 | 163509 | 0 | None | -4 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 460 | 9 | 2 | 5 | 4.0 | C(=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)\CNCC1CCOCC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4070320 | 163509 | 0 | None | -4 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 460 | 9 | 2 | 5 | 4.0 | C(=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)\CNCC1CCOCC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 137647838 | 164364 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 392 | 7 | 2 | 4 | 4.0 | CC(C)(N)CCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4080718 | 164364 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 392 | 7 | 2 | 4 | 4.0 | CC(C)(N)CCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.7b01420 | ||
| 53324117 | 63686 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 373 | 5 | 2 | 5 | 4.1 | NCc1cocc1N(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644096 | 63686 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 373 | 5 | 2 | 5 | 4.1 | NCc1cocc1N(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 135313730 | 169519 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 431 | 3 | 1 | 5 | 3.2 | CN1CCN(c2cccc3c2C[C@H](CN2CCC[C@H]4CCc5cccnc5[C@H]42)NC3)CC1 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4171365 | 169519 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 431 | 3 | 1 | 5 | 3.2 | CN1CCN(c2cccc3c2C[C@H](CN2CCC[C@H]4CCc5cccnc5[C@H]42)NC3)CC1 | 10.1021/acs.jmedchem.8b00450 | ||
| 122192916 | 130670 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 317 | 7 | 3 | 5 | 1.1 | NCCCCN(C[C@H]1CNCCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627788 | 130670 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 317 | 7 | 3 | 5 | 1.1 | NCCCCN(C[C@H]1CNCCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 59176485 | 158651 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 595 | 10 | 2 | 8 | 4.1 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21)NC1CCOCC1 | nan | ||
| CHEMBL3965617 | 158651 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 595 | 10 | 2 | 8 | 4.1 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21)NC1CCOCC1 | nan | ||
| 11718722 | 23428 | 13 | None | -1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| CHEMBL1242210 | 23428 | 13 | None | -1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| 145955884 | 169180 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 431 | 6 | 2 | 5 | 3.3 | c1cnc2c(c1)CCC[C@@H]2N(CC1CC1)C[C@H]1Cc2c(cccc2N2CCNCC2)CN1 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4165854 | 169180 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 431 | 6 | 2 | 5 | 3.3 | c1cnc2c(c1)CCC[C@@H]2N(CC1CC1)C[C@H]1Cc2c(cccc2N2CCNCC2)CN1 | 10.1021/acs.jmedchem.8b00450 | ||
| 135313980 | 168879 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 342 | 8 | 2 | 4 | 2.5 | NCCCCN(Cc1ccc(F)cn1)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4161140 | 168879 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 342 | 8 | 2 | 4 | 2.5 | NCCCCN(Cc1ccc(F)cn1)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm300862u | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm300862u | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm300862u | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm300862u | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm300862u | ||
| 145955694 | 169277 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 420 | 7 | 2 | 6 | 2.2 | c1cnc2c(c1)CN[C@H](CN(CCCN1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4167467 | 169277 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 420 | 7 | 2 | 6 | 2.2 | c1cnc2c(c1)CN[C@H](CN(CCCN1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| 53321040 | 65161 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 325 | 7 | 2 | 5 | 2.7 | NCCCCN(Cc1ncccc1N)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682863 | 65161 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 325 | 7 | 2 | 5 | 2.7 | NCCCCN(Cc1ncccc1N)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2009.01.014 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2009.01.014 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2009.01.014 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2009.01.014 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2009.01.014 | ||
| 59176475 | 149730 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 524 | 9 | 1 | 6 | 5.2 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCCCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3894168 | 149730 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 524 | 9 | 1 | 6 | 5.2 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCCCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 145960175 | 168907 | 0 | None | 27 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | C/C(CN)=C(\F)CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4161528 | 168907 | 0 | None | 27 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | C/C(CN)=C(\F)CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| 145958296 | 169061 | 0 | None | 38 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 376 | 6 | 2 | 4 | 3.4 | C/C(=C/CN)CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4164075 | 169061 | 0 | None | 38 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 376 | 6 | 2 | 4 | 3.4 | C/C(=C/CN)CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| 21984983 | 15127 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 397 | 6 | 2 | 4 | 4.5 | NCc1ccccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1093008 | 15127 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 397 | 6 | 2 | 4 | 4.5 | NCc1ccccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 142416967 | 169535 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 404 | 5 | 2 | 4 | 4.0 | N[C@H]1CC[C@H](CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4171643 | 169535 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 404 | 5 | 2 | 4 | 4.0 | N[C@H]1CC[C@H](CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.7b00406 | ||
| 59176563 | 153016 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 442 | 5 | 1 | 6 | 5.1 | CC(C)(C)OC(=O)Cn1c2ccccc2c2ccnc(CN[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3920427 | 153016 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 442 | 5 | 1 | 6 | 5.1 | CC(C)(C)OC(=O)Cn1c2ccccc2c2ccnc(CN[C@H]3CCCc4cccnc43)c21 | nan | ||
| 59176610 | 149833 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 617 | 12 | 1 | 8 | 5.3 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCCNCc3ccncc3)[C@H]3CCCc4cccnc43)c21)N1CCOCC1 | nan | ||
| CHEMBL3895085 | 149833 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 617 | 12 | 1 | 8 | 5.3 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCCNCc3ccncc3)[C@H]3CCCc4cccnc43)c21)N1CCOCC1 | nan | ||
| 135313715 | 163722 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 503 | 9 | 2 | 5 | 5.4 | c1ccc(CNCc2ccc(CN(C[C@H]3Cc4ccccc4CN3)[C@H]3CCCc4cccnc43)cc2)nc1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4072645 | 163722 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 503 | 9 | 2 | 5 | 5.4 | c1ccc(CNCc2ccc(CN(C[C@H]3Cc4ccccc4CN3)[C@H]3CCCc4cccnc43)cc2)nc1 | 10.1021/acs.jmedchem.7b01420 | ||
| 137643317 | 165195 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 448 | 9 | 2 | 5 | 4.0 | c1ccc2c(c1)CN[C@@H](CN(CCCCNC1CCOCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4090235 | 165195 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 448 | 9 | 2 | 5 | 4.0 | c1ccc2c(c1)CN[C@@H](CN(CCCCNC1CCOCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| 145954818 | 169337 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 405 | 4 | 1 | 5 | 2.9 | CN1CCN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)CC1 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4168391 | 169337 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 405 | 4 | 1 | 5 | 2.9 | CN1CCN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)CC1 | 10.1021/acs.jmedchem.8b00450 | ||
| 155519969 | 177143 | 0 | None | -2 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 492 | 8 | 1 | 6 | 6.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(Cl)c2o1 | 10.1016/j.bmc.2019.115091 | ||
| CHEMBL4447627 | 177143 | 0 | None | -2 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 492 | 8 | 1 | 6 | 6.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(Cl)c2o1 | 10.1016/j.bmc.2019.115091 | ||
| 135313976 | 169345 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 338 | 8 | 2 | 4 | 2.6 | Cc1cccc(CN(CCCCN)C[C@H]2Cc3ccccc3CN2)n1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4168512 | 169345 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 338 | 8 | 2 | 4 | 2.6 | Cc1cccc(CN(CCCCN)C[C@H]2Cc3ccccc3CN2)n1 | 10.1021/acsmedchemlett.7b00381 | ||
| 135313773 | 163967 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 412 | 6 | 2 | 4 | 4.1 | NCc1cccc(CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)c1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4075694 | 163967 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 412 | 6 | 2 | 4 | 4.1 | NCc1cccc(CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)c1 | 10.1021/acs.jmedchem.7b01420 | ||
| 57345320 | 10604 | 9 | None | 34 | 7 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| 9882 | 10604 | 9 | None | 34 | 7 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| CHEMBL3091687 | 10604 | 9 | None | 34 | 7 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| 76331766 | 110609 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 407 | 8 | 3 | 4 | 2.9 | NC(=O)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091685 | 110609 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 407 | 8 | 3 | 4 | 2.9 | NC(=O)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 25178136 | 195719 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | C1=C(CS/C(=N\C2CCCCCC2)NC2CCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL508054 | 195719 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | C1=C(CS/C(=N\C2CCCCCC2)NC2CCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| 11718722 | 23428 | 13 | None | -1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| CHEMBL1242210 | 23428 | 13 | None | -1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| 145963140 | 168972 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 4 | 1 | 5 | 3.4 | CN(C[C@H]1Cc2c(cccc2N2CCN3CCC[C@@H]3C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4162609 | 168972 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 4 | 1 | 5 | 3.4 | CN(C[C@H]1Cc2c(cccc2N2CCN3CCC[C@@H]3C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 137635041 | 162801 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 482 | 9 | 2 | 4 | 5.4 | FC1(F)CCC(NCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4062223 | 162801 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 482 | 9 | 2 | 4 | 5.4 | FC1(F)CCC(NCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 70924213 | 150308 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 4.7 | NCCCCN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3898910 | 150308 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 4.7 | NCCCCN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| 59176413 | 150395 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 525 | 10 | 2 | 7 | 3.6 | NCCCn1c2ccccc2c2ccnc(CN(CCCN3CCNC(=O)C3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3899664 | 150395 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 525 | 10 | 2 | 7 | 3.6 | NCCCn1c2ccccc2c2ccnc(CN(CCCN3CCNC(=O)C3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 59176465 | 150736 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 539 | 9 | 1 | 7 | 4.0 | CN1CCN(C(=O)Cn2c3ccccc3c3ccnc(CN(CCCCN)[C@H]4CCCc5cccnc54)c32)CC1 | nan | ||
| CHEMBL3902493 | 150736 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 539 | 9 | 1 | 7 | 4.0 | CN1CCN(C(=O)Cn2c3ccccc3c3ccnc(CN(CCCCN)[C@H]4CCCc5cccnc54)c32)CC1 | nan | ||
| 145952723 | 169258 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 469 | 5 | 1 | 7 | 3.2 | CN(C[C@H]1Cc2c(cccc2N2CCN(c3ncccn3)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4167145 | 169258 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 469 | 5 | 1 | 7 | 3.2 | CN(C[C@H]1Cc2c(cccc2N2CCN(c3ncccn3)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 3001322 | 7231 | 23 | None | -75857 | 5 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | ||
| 805 | 7231 | 23 | None | -75857 | 5 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | ||
| CHEMBL1255794 | 7231 | 23 | None | -75857 | 5 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | ||
| DB06497 | 7231 | 23 | None | -75857 | 5 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 577 | 10 | 3 | 6 | 4.6 | CCCCN1C(=O)[C@H](NC(=O)C21CCN(CC2)Cc1ccc(cc1)Oc1ccc(cc1)C(=O)O)[C@@H](C1CCCCC1)O | 10.1016/j.bmc.2011.05.022 | ||
| 25178142 | 197364 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 430 | 4 | 1 | 5 | 5.2 | C1=C(CS/C(=N\C2CCCCC2)NC23CC4CC(CC(C4)C2)C3)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL518041 | 197364 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 430 | 4 | 1 | 5 | 5.2 | C1=C(CS/C(=N\C2CCCCC2)NC23CC4CC(CC(C4)C2)C3)N2CCN=C2S1 | 10.1021/jm801065q | ||
| 59176389 | 152535 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 490 | 9 | 1 | 6 | 5.6 | NCCCCN(Cc1nccc2c3ccccc3n(Cc3ccccn3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3916633 | 152535 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 490 | 9 | 1 | 6 | 5.6 | NCCCCN(Cc1nccc2c3ccccc3n(Cc3ccccn3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 145957239 | 168937 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 391 | 4 | 2 | 5 | 2.5 | CN(C[C@@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4162011 | 168937 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 391 | 4 | 2 | 5 | 2.5 | CN(C[C@@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 145953325 | 169195 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 405 | 4 | 1 | 5 | 2.9 | CN(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1C)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4166059 | 169195 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 405 | 4 | 1 | 5 | 2.9 | CN(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1C)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 145971507 | 169887 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 419 | 6 | 2 | 5 | 3.3 | CCCN(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4177130 | 169887 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 419 | 6 | 2 | 5 | 3.3 | CCCN(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 25147749 | 8875 | 18 | None | -18 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.0c00444 | ||
| 2899 | 8875 | 18 | None | -18 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.0c00444 | ||
| CHEMBL460491 | 8875 | 18 | None | -18 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.0c00444 | ||
| 46204212 | 15064 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 363 | 6 | 2 | 4 | 3.1 | NCCCC(=O)N(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1092629 | 15064 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 363 | 6 | 2 | 4 | 3.1 | NCCCC(=O)N(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 44242331 | 158960 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 3.5 | Cn1c(CN(CCCCN)C2CCCc3cccnc32)nnc1-c1ccccc1 | nan | ||
| CHEMBL3968349 | 158960 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 3.5 | Cn1c(CN(CCCCN)C2CCCc3cccnc32)nnc1-c1ccccc1 | nan | ||
| 135314218 | 169610 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 356 | 8 | 2 | 4 | 2.8 | Cc1cnc(CN(CCCCN)C[C@H]2Cc3ccccc3CN2)c(F)c1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4172727 | 169610 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 356 | 8 | 2 | 4 | 2.8 | Cc1cnc(CN(CCCCN)C[C@H]2Cc3ccccc3CN2)c(F)c1 | 10.1021/acsmedchemlett.7b00381 | ||
| 25147749 | 8875 | 18 | None | -18 | 2 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1039/c9md00433e | ||
| 2899 | 8875 | 18 | None | -18 | 2 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1039/c9md00433e | ||
| CHEMBL460491 | 8875 | 18 | None | -18 | 2 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1039/c9md00433e | ||
| 59176593 | 150087 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 515 | 6 | 0 | 6 | 5.4 | CN(Cc1nccc2c3ccccc3n(CCN3C(=O)c4ccccc4C3=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3897144 | 150087 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 515 | 6 | 0 | 6 | 5.4 | CN(Cc1nccc2c3ccccc3n(CCN3C(=O)c4ccccc4C3=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 145971189 | 169795 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 447 | 8 | 1 | 5 | 3.5 | CCN1CCN(CCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4175653 | 169795 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 447 | 8 | 1 | 5 | 3.5 | CCN1CCN(CCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.8b00030 | ||
| 146398479 | 191251 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 405 | 4 | 2 | 5 | 3.0 | CN(C[C@H]1Cc2c(cccc2N2CCC(N)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL4846946 | 191251 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 405 | 4 | 2 | 5 | 3.0 | CN(C[C@H]1Cc2c(cccc2N2CCC(N)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| 145960079 | 169127 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 419 | 4 | 2 | 5 | 3.3 | CN(C[C@H]1Cc2c(cccc2N2CCNC(C)(C)C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4164970 | 169127 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 419 | 4 | 2 | 5 | 3.3 | CN(C[C@H]1Cc2c(cccc2N2CCNC(C)(C)C2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 162652106 | 187081 | 0 | None | -123 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 1090 | 24 | 7 | 15 | 5.0 | CC1(C)CN2C(CS/C(=N\[C@H]3CC[C@H](CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@@H]4CC[C@@]5(O)[C@H]6Cc7ccc(O)c8c7[C@@]5(CCN6CC5CC5)[C@H]4O8)CC3)NC3CCCCC3)=CSC2=N1 | 10.1039/c9md00433e | ||
| CHEMBL4750948 | 187081 | 0 | None | -123 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 1090 | 24 | 7 | 15 | 5.0 | CC1(C)CN2C(CS/C(=N\[C@H]3CC[C@H](CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@@H]4CC[C@@]5(O)[C@H]6Cc7ccc(O)c8c7[C@@]5(CCN6CC5CC5)[C@H]4O8)CC3)NC3CCCCC3)=CSC2=N1 | 10.1039/c9md00433e | ||
| 135313757 | 169842 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 374 | 8 | 2 | 4 | 3.5 | NCCCCN(Cc1cc2ccccc2cn1)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4176370 | 169842 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 374 | 8 | 2 | 4 | 3.5 | NCCCCN(Cc1cc2ccccc2cn1)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 59176471 | 158455 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 454 | 7 | 2 | 5 | 4.3 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1cc2c(cn1)[nH]c1ccccc12 | nan | ||
| CHEMBL3964095 | 158455 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 454 | 7 | 2 | 5 | 4.3 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1cc2c(cn1)[nH]c1ccccc12 | nan | ||
| 59176496 | 156234 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 4.8 | CN(Cc1nccc2c3ccccc3n(CCCCN)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3946029 | 156234 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 4.8 | CN(Cc1nccc2c3ccccc3n(CCCCN)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 142416884 | 169753 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 390 | 4 | 2 | 4 | 3.7 | N[C@H]1CC[C@H](N(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4175088 | 169753 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 390 | 4 | 2 | 4 | 3.7 | N[C@H]1CC[C@H](N(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.7b00406 | ||
| 145955917 | 169262 | 0 | None | 29 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 418 | 6 | 2 | 4 | 4.2 | NC[C@H]1CC[C@H](CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4167221 | 169262 | 0 | None | 29 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 418 | 6 | 2 | 4 | 4.2 | NC[C@H]1CC[C@H](CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.7b00406 | ||
| 53321037 | 65154 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.4 | Cc1ccc(CN(CCCCN)C2CCCc3cccnc32)nc1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682856 | 65154 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.4 | Cc1ccc(CN(CCCCN)C2CCCc3cccnc32)nc1 | 10.1016/j.bmcl.2011.01.021 | ||
| 122192922 | 130677 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 411 | 8 | 2 | 6 | 2.2 | NCCCCN(C[C@@H]1CN(C(=O)c2ccco2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627798 | 130677 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 411 | 8 | 2 | 6 | 2.2 | NCCCCN(C[C@@H]1CN(C(=O)c2ccco2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 146398482 | 193259 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 433 | 5 | 1 | 5 | 3.6 | CN(C)C1CCN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)CC1 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL4876951 | 193259 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 433 | 5 | 1 | 5 | 3.6 | CN(C)C1CCN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)CC1 | 10.1021/acsmedchemlett.1c00449 | ||
| 72546061 | 110612 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 455 | 9 | 1 | 5 | 4.5 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1cccnc1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091689 | 110612 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 455 | 9 | 1 | 5 | 4.5 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1cccnc1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 71451639 | 88951 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 414 | 12 | 2 | 4 | 4.4 | C[C@@H]1CCCCN1CCCNCc1ccc(CNCCCN2CCCC[C@H]2C)cc1 | 10.1021/jm300862u | ||
| CHEMBL2170298 | 88951 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 414 | 12 | 2 | 4 | 4.4 | C[C@@H]1CCCCN1CCCNCc1ccc(CNCCCN2CCCC[C@H]2C)cc1 | 10.1021/jm300862u | ||
| CHEMBL2170444 | 88951 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 414 | 12 | 2 | 4 | 4.4 | C[C@@H]1CCCCN1CCCNCc1ccc(CNCCCN2CCCC[C@H]2C)cc1 | 10.1021/jm300862u | ||
| 155569501 | 182971 | 0 | None | 1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 450 | 7 | 1 | 6 | 5.9 | c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 | 10.1016/j.bmc.2019.115091 | ||
| CHEMBL4593522 | 182971 | 0 | None | 1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 450 | 7 | 1 | 6 | 5.9 | c1ccc(-c2nnn[nH]2)c(-c2ccc(CN(CC3CCCC3)c3nc4ccccc4o3)cc2)c1 | 10.1016/j.bmc.2019.115091 | ||
| 70924216 | 156337 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 425 | 5 | 2 | 4 | 5.0 | c1cnc2c(c1)CCC[C@@H]2N(Cc1nccc2c1[nH]c1ccccc12)CC1CCCNC1 | nan | ||
| CHEMBL3946745 | 156337 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 425 | 5 | 2 | 4 | 5.0 | c1cnc2c(c1)CCC[C@@H]2N(Cc1nccc2c1[nH]c1ccccc12)CC1CCCNC1 | nan | ||
| 137633531 | 163059 | 0 | None | -1 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 476 | 9 | 2 | 5 | 4.7 | CC(C)(CCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)CNC1CCOCC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4065224 | 163059 | 0 | None | -1 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 476 | 9 | 2 | 5 | 4.7 | CC(C)(CCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)CNC1CCOCC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 137651429 | 164061 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 461 | 10 | 3 | 5 | 3.8 | c1ccc2c(c1)CN[C@@H](CN(CCCCNCC1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4076841 | 164061 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 461 | 10 | 3 | 5 | 3.8 | c1ccc2c(c1)CN[C@@H](CN(CCCCNCC1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| 145949949 | 169678 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 419 | 5 | 2 | 5 | 3.3 | CC(C)N(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4173777 | 169678 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 419 | 5 | 2 | 5 | 3.3 | CC(C)N(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 59176557 | 153685 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 568 | 9 | 1 | 8 | 5.1 | CC(C)(C)OC(=O)Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3925646 | 153685 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 568 | 9 | 1 | 8 | 5.1 | CC(C)(C)OC(=O)Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 70924238 | 158609 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 502 | 6 | 2 | 5 | 5.6 | c1ccc(N2CCNCC2)c(CN(Cc2nccc3c2[nH]c2ccccc23)[C@H]2CCCc3cccnc32)c1 | nan | ||
| CHEMBL3965386 | 158609 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 502 | 6 | 2 | 5 | 5.6 | c1ccc(N2CCNCC2)c(CN(Cc2nccc3c2[nH]c2ccccc23)[C@H]2CCCc3cccnc32)c1 | nan | ||
| 53321038 | 65156 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 338 | 7 | 1 | 4 | 3.7 | Cc1cc(C)nc(CN(CCCCN)C2CCCc3cccnc32)c1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682858 | 65156 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 338 | 7 | 1 | 4 | 3.7 | Cc1cc(C)nc(CN(CCCCN)C2CCCc3cccnc32)c1 | 10.1016/j.bmcl.2011.01.021 | ||
| 70924219 | 159452 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 470 | 8 | 2 | 4 | 5.0 | CN(C)C(=O)NCCCCN(Cc1nccc2c1[nH]c1ccccc12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3972688 | 159452 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 470 | 8 | 2 | 4 | 5.0 | CN(C)C(=O)NCCCCN(Cc1nccc2c1[nH]c1ccccc12)C1CCCc2cccnc21 | nan | ||
| 2795811 | 35939 | 23 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 275 | 2 | 0 | 5 | 3.2 | CSc1nnc(-c2ccc(C(F)(F)F)nc2C)o1 | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL1381819 | 35939 | 23 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 275 | 2 | 0 | 5 | 3.2 | CSc1nnc(-c2ccc(C(F)(F)F)nc2C)o1 | 10.1016/j.ejmech.2017.08.027 | ||
| 142416935 | 169759 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 5 | 1 | 6 | 2.6 | CN(C[C@H]1Cc2c(cccc2N2CCN(C3COC3)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4175201 | 169759 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 5 | 1 | 6 | 2.6 | CN(C[C@H]1Cc2c(cccc2N2CCN(C3COC3)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 20725627 | 63673 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 455 | 7 | 2 | 6 | 4.3 | COC(=O)c1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c(CN)c1 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644077 | 63673 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 455 | 7 | 2 | 6 | 4.3 | COC(=O)c1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c(CN)c1 | 10.1016/j.bmcl.2010.11.023 | ||
| 122192967 | 130683 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 513 | 9 | 2 | 7 | 3.4 | NCCCCN(C[C@H]1CN(S(=O)(=O)c2cc3ccccc3s2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627861 | 130683 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 513 | 9 | 2 | 7 | 3.4 | NCCCCN(C[C@H]1CN(S(=O)(=O)c2cc3ccccc3s2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 72546065 | 110616 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 378 | 7 | 1 | 4 | 3.6 | CN1Cc2ccccc2C[C@@H]1CN(CCCCN)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091693 | 110616 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 378 | 7 | 1 | 4 | 3.6 | CN1Cc2ccccc2C[C@@H]1CN(CCCCN)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 155567133 | 182658 | 0 | None | -1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 472 | 8 | 1 | 6 | 6.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(C)c2o1 | 10.1016/j.bmc.2019.115091 | ||
| CHEMBL4586253 | 182658 | 0 | None | -1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 472 | 8 | 1 | 6 | 6.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)cc(C)c2o1 | 10.1016/j.bmc.2019.115091 | ||
| 76335355 | 110608 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 406 | 8 | 2 | 4 | 3.4 | CC(=O)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091684 | 110608 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 406 | 8 | 2 | 4 | 3.4 | CC(=O)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 59176550 | 151586 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 539 | 11 | 2 | 7 | 4.0 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN3CCNC(=O)C3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3909409 | 151586 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 539 | 11 | 2 | 7 | 4.0 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN3CCNC(=O)C3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 59176372 | 157627 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 512 | 10 | 1 | 7 | 4.5 | NCCCCN(Cc1nccc2c3ccccc3n(CCN3CCOCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3957139 | 157627 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 512 | 10 | 1 | 7 | 4.5 | NCCCCN(Cc1nccc2c3ccccc3n(CCN3CCOCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 59176621 | 159660 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 453 | 9 | 1 | 5 | 5.6 | NCCCCN(Cc1nccc2c3ccccc3n(CC3CC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3974510 | 159660 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 453 | 9 | 1 | 5 | 5.6 | NCCCCN(Cc1nccc2c3ccccc3n(CC3CC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 11718722 | 23428 | 13 | None | -2 | 4 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| CHEMBL1242210 | 23428 | 13 | None | -2 | 4 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| 145957599 | 168768 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 482 | 6 | 1 | 6 | 3.8 | CN(C[C@H]1Cc2c(cccc2N2CCN(Cc3ccccn3)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4159234 | 168768 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 482 | 6 | 1 | 6 | 3.8 | CN(C[C@H]1Cc2c(cccc2N2CCN(Cc3ccccn3)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 138501437 | 189946 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 366 | 4 | 0 | 6 | 2.6 | Cc1ccc([C@@H]2CCCN2Cc2cc(N3CCN(C)CC3)nc(C)n2)nc1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4795444 | 189946 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 366 | 4 | 0 | 6 | 2.6 | Cc1ccc([C@@H]2CCCN2Cc2cc(N3CCN(C)CC3)nc(C)n2)nc1 | 10.1016/j.ejmech.2020.112537 | ||
| 135314390 | 165251 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 453 | 9 | 2 | 5 | 4.2 | C(=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)\CNCc1ccncc1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4090772 | 165251 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 453 | 9 | 2 | 5 | 4.2 | C(=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)\CNCc1ccncc1 | 10.1021/acs.jmedchem.7b01420 | ||
| 46189876 | 170315 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 349 | 4 | 3 | 4 | 3.3 | Cn1ccc2c(NC(=O)NCCc3ccc4c(n3)NCCC4)cccc21 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL4202860 | 170315 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 349 | 4 | 3 | 4 | 3.3 | Cn1ccc2c(NC(=O)NCCc3ccc4c(n3)NCCC4)cccc21 | 10.1016/j.ejmech.2018.02.043 | ||
| 59176611 | 159212 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 579 | 9 | 1 | 7 | 4.8 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21)N1CCCCC1 | nan | ||
| CHEMBL3970736 | 159212 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 579 | 9 | 1 | 7 | 4.8 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21)N1CCCCC1 | nan | ||
| 142416759 | 169643 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 392 | 8 | 2 | 4 | 3.4 | NCCCCN(Cc1ncccc1C(F)(F)F)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4173145 | 169643 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 392 | 8 | 2 | 4 | 3.4 | NCCCCN(Cc1ncccc1C(F)(F)F)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 59176414 | 150118 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 500 | 10 | 1 | 7 | 3.7 | CC(c1ccccn1)N(CCCCN)Cc1nccc2c3ccccc3n(CC(=O)N3CCOCC3)c12 | nan | ||
| CHEMBL3897384 | 150118 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 500 | 10 | 1 | 7 | 3.7 | CC(c1ccccn1)N(CCCCN)Cc1nccc2c3ccccc3n(CC(=O)N3CCOCC3)c12 | nan | ||
| 137640446 | 163821 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 490 | 10 | 2 | 5 | 4.9 | CC(C)(CCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)CNCC1CCOCC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4073818 | 163821 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 490 | 10 | 2 | 5 | 4.9 | CC(C)(CCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)CNCC1CCOCC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 135313705 | 168941 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 366 | 7 | 1 | 6 | 2.0 | c1cnc(CN(CCCN2CCNCC2)[C@H]2CCCc3cccnc32)nc1 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4162125 | 168941 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 366 | 7 | 1 | 6 | 2.0 | c1cnc(CN(CCCN2CCNCC2)[C@H]2CCCc3cccnc32)nc1 | 10.1021/acsmedchemlett.8b00030 | ||
| 25178569 | 183772 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 434 | 4 | 1 | 5 | 5.9 | CC(C)(C)C1CCC(N/C(=N/C2CCCCC2)SCC2=CSC3=NCCN23)CC1 | 10.1021/jm801065q | ||
| CHEMBL462588 | 183772 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 434 | 4 | 1 | 5 | 5.9 | CC(C)(C)C1CCC(N/C(=N/C2CCCCC2)SCC2=CSC3=NCCN23)CC1 | 10.1021/jm801065q | ||
| 59176519 | 152571 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 539 | 9 | 2 | 7 | 4.2 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCC(N)CC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3916930 | 152571 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 539 | 9 | 2 | 7 | 4.2 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCC(N)CC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2017.08.027 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2017.08.027 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2017.08.027 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2017.08.027 | ||
| 145951963 | 169781 | 0 | None | 199 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | C/C(CN)=C(/F)CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4175500 | 169781 | 0 | None | 199 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | C/C(CN)=C(/F)CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| 25177627 | 65164 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 344 | 7 | 1 | 4 | 3.7 | NCCCCN(Cc1ncccc1Cl)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682866 | 65164 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 344 | 7 | 1 | 4 | 3.7 | NCCCCN(Cc1ncccc1Cl)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| 89667390 | 149215 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 580 | 10 | 1 | 8 | 4.8 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21)C1CCOCC1 | nan | ||
| CHEMBL3890057 | 149215 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 580 | 10 | 1 | 8 | 4.8 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21)C1CCOCC1 | nan | ||
| 59176455 | 152655 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 641 | 11 | 1 | 8 | 5.4 | O=C1c2ccccc2C(=O)N1CCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3917572 | 152655 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 641 | 11 | 1 | 8 | 5.4 | O=C1c2ccccc2C(=O)N1CCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 59176424 | 156540 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 581 | 9 | 1 | 8 | 3.6 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21)N1CCOCC1 | nan | ||
| CHEMBL3948247 | 156540 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 581 | 9 | 1 | 8 | 3.6 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21)N1CCOCC1 | nan | ||
| 59176442 | 158296 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 594 | 11 | 2 | 8 | 3.6 | O=C1CNCCN1CCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3962780 | 158296 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 594 | 11 | 2 | 8 | 3.6 | O=C1CNCCN1CCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 46884785 | 15063 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 359 | 7 | 1 | 4 | 4.5 | N#CCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1092628 | 15063 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 359 | 7 | 1 | 4 | 4.5 | N#CCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 135313919 | 168914 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 404 | 7 | 2 | 5 | 3.1 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1nc2ccccc2[nH]1 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4161613 | 168914 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 404 | 7 | 2 | 5 | 3.1 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1nc2ccccc2[nH]1 | 10.1021/acsmedchemlett.8b00030 | ||
| 137647645 | 164430 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 496 | 9 | 2 | 6 | 3.4 | O=S1(=O)CCC(NCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4081436 | 164430 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 496 | 9 | 2 | 6 | 3.4 | O=S1(=O)CCC(NCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 70924169 | 155380 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 453 | 10 | 2 | 4 | 5.8 | c1cnc2c(c1)CCC[C@@H]2N(CCCCNCC1CC1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| CHEMBL3939176 | 155380 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 453 | 10 | 2 | 4 | 5.8 | c1cnc2c(c1)CCC[C@@H]2N(CCCCNCC1CC1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| 59176428 | 158991 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 489 | 9 | 1 | 5 | 6.3 | NCCCCN(Cc1nccc2c3ccccc3n(Cc3ccccc3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3968668 | 158991 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 489 | 9 | 1 | 5 | 6.3 | NCCCCN(Cc1nccc2c3ccccc3n(Cc3ccccc3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 152829285 | 192014 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 420 | 5 | 2 | 6 | 2.7 | CN1CCN(Nc2cccc3c2C[C@@H](CN(C)[C@H]2CCCc4cccnc42)NC3)CC1 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL4858136 | 192014 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 420 | 5 | 2 | 6 | 2.7 | CN1CCN(Nc2cccc3c2C[C@@H](CN(C)[C@H]2CCCc4cccnc42)NC3)CC1 | 10.1021/acsmedchemlett.1c00449 | ||
| 137647643 | 164418 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 546 | 12 | 1 | 6 | 5.7 | c1cncc(CN(CCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)Cc2cccnc2)c1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4081338 | 164418 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 546 | 12 | 1 | 6 | 5.7 | c1cncc(CN(CCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)Cc2cccnc2)c1 | 10.1021/acs.jmedchem.7b01420 | ||
| 59176397 | 158852 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 490 | 9 | 1 | 6 | 5.6 | NCCCCN(Cc1nccc2c3ccccc3n(Cc3cccnc3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3967462 | 158852 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 490 | 9 | 1 | 6 | 5.6 | NCCCCN(Cc1nccc2c3ccccc3n(Cc3cccnc3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 145974804 | 169855 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 350 | 9 | 2 | 4 | 3.0 | C=Cc1cccnc1CN(CCCCN)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4176514 | 169855 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 350 | 9 | 2 | 4 | 3.0 | C=Cc1cccnc1CN(CCCCN)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 53318414 | 65158 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 325 | 7 | 2 | 5 | 2.7 | NCCCCN(Cc1cccc(N)n1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682860 | 65158 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 325 | 7 | 2 | 5 | 2.7 | NCCCCN(Cc1cccc(N)n1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| 59176467 | 158684 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 512 | 10 | 1 | 7 | 4.4 | COCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3966015 | 158684 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 512 | 10 | 1 | 7 | 4.4 | COCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 72546063 | 110614 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 445 | 9 | 1 | 6 | 4.1 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1cocn1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091691 | 110614 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 445 | 9 | 1 | 6 | 4.1 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1cocn1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 25178134 | 180942 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 350 | 4 | 1 | 5 | 3.8 | C1=C(CS/C(=N\C2CCCC2)NC2CCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL454689 | 180942 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 350 | 4 | 1 | 5 | 3.8 | C1=C(CS/C(=N\C2CCCC2)NC2CCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| 145955745 | 169339 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 509 | 6 | 2 | 5 | 4.7 | FC1(F)CCC(CN(C[C@H]2Cc3c(cccc3N3CCNCC3)CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4168418 | 169339 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 509 | 6 | 2 | 5 | 4.7 | FC1(F)CCC(CN(C[C@H]2Cc3c(cccc3N3CCNCC3)CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.8b00450 | ||
| 11256587 | 9240 | 59 | None | 389 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/acsmedchemlett.8b00030 | ||
| 8580 | 9240 | 59 | None | 389 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL518924 | 9240 | 59 | None | 389 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/acsmedchemlett.8b00030 | ||
| DB05501 | 9240 | 59 | None | 389 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/acsmedchemlett.8b00030 | ||
| 53320374 | 63668 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 427 | 7 | 2 | 5 | 4.5 | COc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c(CN)c1 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644072 | 63668 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 427 | 7 | 2 | 5 | 4.5 | COc1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c(CN)c1 | 10.1016/j.bmcl.2010.11.023 | ||
| 53316607 | 63675 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 454 | 8 | 2 | 6 | 4.5 | CO/N=C/c1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c(CN)c1 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644079 | 63675 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 454 | 8 | 2 | 6 | 4.5 | CO/N=C/c1ccc(CN(Cc2nc3ccccc3[nH]2)C2CCCc3cccnc32)c(CN)c1 | 10.1016/j.bmcl.2010.11.023 | ||
| 59176450 | 152000 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 511 | 10 | 2 | 7 | 4.1 | NCCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3912613 | 152000 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 511 | 10 | 2 | 7 | 4.1 | NCCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 11256587 | 9240 | 59 | None | 389 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/acsmedchemlett.1c00449 | ||
| 8580 | 9240 | 59 | None | 389 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL518924 | 9240 | 59 | None | 389 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/acsmedchemlett.1c00449 | ||
| DB05501 | 9240 | 59 | None | 389 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/acsmedchemlett.1c00449 | ||
| 25178563 | 181024 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 434 | 4 | 1 | 5 | 6.2 | C1=C(CS/C(=N\C2CCCCCCC2)NC2CCCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL454896 | 181024 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 434 | 4 | 1 | 5 | 6.2 | C1=C(CS/C(=N\C2CCCCCCC2)NC2CCCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| 23653628 | 70584 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 562 | 11 | 2 | 9 | 3.4 | CCOCCN1CCN(C(=O)c2cnc(NCc3ccc(CNc4ncc(F)cn4)cc3)nc2C(F)(F)F)CC1 | 10.1021/jm100786g | ||
| CHEMBL1802329 | 70584 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 562 | 11 | 2 | 9 | 3.4 | CCOCCN1CCN(C(=O)c2cnc(NCc3ccc(CNc4ncc(F)cn4)cc3)nc2C(F)(F)F)CC1 | 10.1021/jm100786g | ||
| 145953403 | 169293 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 459 | 8 | 1 | 5 | 3.6 | c1ccc2c(c1)CN[C@@H](CN(CCCN1CCN(C3CC3)CC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4167654 | 169293 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 459 | 8 | 1 | 5 | 3.6 | c1ccc2c(c1)CN[C@@H](CN(CCCN1CCN(C3CC3)CC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| 21984983 | 15127 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 397 | 6 | 2 | 4 | 4.5 | NCc1ccccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1093008 | 15127 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 397 | 6 | 2 | 4 | 4.5 | NCc1ccccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 25147749 | 8875 | 18 | None | -18 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 2899 | 8875 | 18 | None | -18 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL460491 | 8875 | 18 | None | -18 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL2372997 | 217119 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| 137647336 | 164757 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 412 | 6 | 2 | 4 | 4.1 | NCc1ccccc1CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4084920 | 164757 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 412 | 6 | 2 | 4 | 4.1 | NCc1ccccc1CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL1956255 | 215883 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmcl.2012.01.134 | ||||
| 21985149 | 63667 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 465 | 6 | 2 | 4 | 5.5 | NCc1cc(C(F)(F)F)ccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644071 | 63667 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 465 | 6 | 2 | 4 | 5.5 | NCc1cc(C(F)(F)F)ccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 135314362 | 169197 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 365 | 5 | 2 | 5 | 1.9 | Cc1ccc(CN(C)C[C@H]2Cc3c(cccc3N3CCNCC3)CN2)nc1 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4166081 | 169197 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 365 | 5 | 2 | 5 | 1.9 | Cc1ccc(CN(C)C[C@H]2Cc3c(cccc3N3CCNCC3)CN2)nc1 | 10.1021/acs.jmedchem.8b00450 | ||
| 70923310 | 159951 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 490 | 10 | 2 | 5 | 6.0 | c1ccc(CNCCCCN(Cc2nccc3c2[nH]c2ccccc23)C2CCCc3cccnc32)nc1 | nan | ||
| CHEMBL3976878 | 159951 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 490 | 10 | 2 | 5 | 6.0 | c1ccc(CNCCCCN(Cc2nccc3c2[nH]c2ccccc23)C2CCCc3cccnc32)nc1 | nan | ||
| 46204209 | 15056 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 363 | 8 | 2 | 4 | 4.0 | NCCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1092596 | 15056 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 363 | 8 | 2 | 4 | 4.0 | NCCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 137640474 | 163865 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 462 | 10 | 2 | 5 | 4.3 | c1ccc2c(c1)CN[C@@H](CN(CCCCNCC1CCOCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4074366 | 163865 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 462 | 10 | 2 | 5 | 4.3 | c1ccc2c(c1)CN[C@@H](CN(CCCCNCC1CCOCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| 25178347 | 183545 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 372 | 4 | 1 | 5 | 4.8 | C1=C(CS/C(=N\C2CCCCC2)Nc2ccccc2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL460482 | 183545 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 372 | 4 | 1 | 5 | 4.8 | C1=C(CS/C(=N\C2CCCCC2)Nc2ccccc2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| 53322385 | 65155 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.4 | Cc1cccc(CN(CCCCN)C2CCCc3cccnc32)n1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682857 | 65155 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.4 | Cc1cccc(CN(CCCCN)C2CCCc3cccnc32)n1 | 10.1016/j.bmcl.2011.01.021 | ||
| 162669065 | 189517 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 750 | 19 | 5 | 11 | 2.5 | CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)NC[C@H]1CC[C@H](/N=C(\NC2CCCCC2)SCC2=CSC3=NC(C)(C)CN23)CC1 | 10.1021/acsmedchemlett.0c00444 | ||
| CHEMBL4789939 | 189517 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 750 | 19 | 5 | 11 | 2.5 | CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)NC[C@H]1CC[C@H](/N=C(\NC2CCCCC2)SCC2=CSC3=NC(C)(C)CN23)CC1 | 10.1021/acsmedchemlett.0c00444 | ||
| 145953739 | 169449 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 447 | 7 | 0 | 5 | 3.5 | CN1CCN(CCCN(C[C@H]2Cc3ccccc3CN2C)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4170141 | 169449 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 447 | 7 | 0 | 5 | 3.5 | CN1CCN(CCCN(C[C@H]2Cc3ccccc3CN2C)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.8b00030 | ||
| 137633431 | 163320 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 464 | 9 | 2 | 5 | 4.7 | c1ccc2c(c1)CN[C@@H](CN(CCCCNC1CCSCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4068122 | 163320 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 464 | 9 | 2 | 5 | 4.7 | c1ccc2c(c1)CN[C@@H](CN(CCCCNC1CCSCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| 137644813 | 164882 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 502 | 9 | 2 | 4 | 6.5 | CC1(C)CCC(NCC(C)(C)CCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4086662 | 164882 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 502 | 9 | 2 | 4 | 6.5 | CC1(C)CCC(NCC(C)(C)CCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 70924198 | 149559 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 511 | 10 | 2 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CCN3CCNCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3892756 | 149559 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 511 | 10 | 2 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CCN3CCNCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 155550367 | 181069 | 0 | None | -1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 472 | 8 | 1 | 6 | 6.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)c(C)cc2o1 | 10.1016/j.bmc.2019.115091 | ||
| CHEMBL4549880 | 181069 | 0 | None | -1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 472 | 8 | 1 | 6 | 6.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(Cl)c(C)cc2o1 | 10.1016/j.bmc.2019.115091 | ||
| 145953342 | 169221 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 405 | 6 | 2 | 5 | 2.4 | c1ccc2c(c1)CN[C@@H](CN(CCN1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4166456 | 169221 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 405 | 6 | 2 | 5 | 2.4 | c1ccc2c(c1)CN[C@@H](CN(CCN1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| 72545830 | 110611 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 455 | 9 | 1 | 5 | 4.5 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1ccccn1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091688 | 110611 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 455 | 9 | 1 | 5 | 4.5 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1ccccn1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 72535480 | 154125 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 498 | 9 | 2 | 7 | 3.8 | OCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)C3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3929341 | 154125 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 498 | 9 | 2 | 7 | 3.8 | OCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)C3CCCc4cccnc43)c21 | nan | ||
| 59176449 | 157141 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 498 | 9 | 2 | 7 | 3.8 | OCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3953230 | 157141 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 498 | 9 | 2 | 7 | 3.8 | OCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 155538284 | 179178 | 0 | None | -1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 438 | 9 | 1 | 6 | 5.9 | CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 | 10.1016/j.bmc.2019.115091 | ||
| CHEMBL4476545 | 179178 | 0 | None | -1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 438 | 9 | 1 | 6 | 5.9 | CCCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 | 10.1016/j.bmc.2019.115091 | ||
| 70924218 | 153165 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 417 | 7 | 2 | 4 | 4.9 | NCCCCN(Cc1nccc2c1[nH]c1cc(F)ccc12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3921613 | 153165 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 417 | 7 | 2 | 4 | 4.9 | NCCCCN(Cc1nccc2c1[nH]c1cc(F)ccc12)C1CCCc2cccnc21 | nan | ||
| 25178766 | 196623 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 392 | 4 | 1 | 5 | 5.0 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCCC2)N2CCCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL516630 | 196623 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 392 | 4 | 1 | 5 | 5.0 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCCC2)N2CCCN=C2S1 | 10.1021/jm801065q | ||
| 59176510 | 155665 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 4.7 | Cn1c2ccccc2c2cc(CN(CCCCN)[C@H]3CCCc4cccnc43)ncc21 | nan | ||
| CHEMBL3941582 | 155665 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 4.7 | Cn1c2ccccc2c2cc(CN(CCCCN)[C@H]3CCCc4cccnc43)ncc21 | nan | ||
| 72546064 | 110615 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 491 | 9 | 1 | 6 | 2.8 | NCCCCN(C[C@H]1Cc2ccccc2CN1CC(=O)N1CCOCC1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091692 | 110615 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 491 | 9 | 1 | 6 | 2.8 | NCCCCN(C[C@H]1Cc2ccccc2CN1CC(=O)N1CCOCC1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 60202207 | 114280 | 0 | None | - | 1 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 454 | 8 | 1 | 6 | 4.0 | COc1ccc(CN2C3CCCC2CC(NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)cc1 | nan | ||
| CHEMBL3185809 | 114280 | 0 | None | - | 1 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 454 | 8 | 1 | 6 | 4.0 | COc1ccc(CN2C3CCCC2CC(NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)cc1 | nan | ||
| 135313789 | 168890 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 374 | 8 | 2 | 4 | 3.5 | NCCCCN(Cc1ccc2ccccc2n1)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4161263 | 168890 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 374 | 8 | 2 | 4 | 3.5 | NCCCCN(Cc1ccc2ccccc2n1)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 135314251 | 164490 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 453 | 9 | 2 | 5 | 4.2 | C(=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)\CNCc1ccccn1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4081958 | 164490 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 453 | 9 | 2 | 5 | 4.2 | C(=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)\CNCc1ccccn1 | 10.1021/acs.jmedchem.7b01420 | ||
| 59176494 | 149610 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 500 | 10 | 1 | 7 | 3.5 | Cc1cccnc1CN(CCCCN)Cc1nccc2c3ccccc3n(CC(=O)N3CCOCC3)c12 | nan | ||
| CHEMBL3893083 | 149610 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 500 | 10 | 1 | 7 | 3.5 | Cc1cccnc1CN(CCCCN)Cc1nccc2c3ccccc3n(CC(=O)N3CCOCC3)c12 | nan | ||
| 59176557 | 153685 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 568 | 9 | 1 | 8 | 5.1 | CC(C)(C)OC(=O)Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3925646 | 153685 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 568 | 9 | 1 | 8 | 5.1 | CC(C)(C)OC(=O)Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 145950272 | 169526 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 366 | 7 | 2 | 5 | 2.7 | NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCOc2cccnc21 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4171469 | 169526 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 366 | 7 | 2 | 5 | 2.7 | NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCOc2cccnc21 | 10.1021/acsmedchemlett.7b00381 | ||
| 57345320 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00030 | ||
| 9882 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL3091687 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00030 | ||
| 57343752 | 130676 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 421 | 8 | 2 | 5 | 2.6 | NCCCCN(C[C@@H]1CN(C(=O)c2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627794 | 130676 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 421 | 8 | 2 | 5 | 2.6 | NCCCCN(C[C@@H]1CN(C(=O)c2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 145950976 | 169607 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 391 | 4 | 2 | 5 | 2.5 | CN(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4172669 | 169607 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 391 | 4 | 2 | 5 | 2.5 | CN(C[C@H]1Cc2c(cccc2N2CCNCC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.8b00450 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.111914 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.111914 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.111914 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.111914 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112537 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112537 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112537 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112537 | ||
| 57345320 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acs.jmedchem.8b00450 | ||
| 9882 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL3091687 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acs.jmedchem.8b00450 | ||
| 57345320 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.1c00449 | ||
| 9882 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL3091687 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.1c00449 | ||
| 57345320 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acs.jmedchem.7b01420 | ||
| 9882 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL3091687 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acs.jmedchem.7b01420 | ||
| 145956824 | 169040 | 0 | None | 1412 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 376 | 6 | 2 | 4 | 3.1 | NCC1CC1CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4163770 | 169040 | 0 | None | 1412 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 376 | 6 | 2 | 4 | 3.1 | NCC1CC1CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.7b00406 | ||
| 25178138 | 201706 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 392 | 4 | 1 | 5 | 5.0 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL541728 | 201706 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 392 | 4 | 1 | 5 | 5.0 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| 11718722 | 23428 | 13 | None | -1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| CHEMBL1242210 | 23428 | 13 | None | -1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| 53319240 | 63680 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 403 | 6 | 2 | 5 | 4.6 | NCc1sccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644085 | 63680 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 403 | 6 | 2 | 5 | 4.6 | NCc1sccc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 135313574 | 166070 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 503 | 9 | 2 | 5 | 5.4 | c1cncc(CNCc2ccc(CN(C[C@H]3Cc4ccccc4CN3)[C@H]3CCCc4cccnc43)cc2)c1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4099550 | 166070 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 503 | 9 | 2 | 5 | 5.4 | c1cncc(CNCc2ccc(CN(C[C@H]3Cc4ccccc4CN3)[C@H]3CCCc4cccnc43)cc2)c1 | 10.1021/acs.jmedchem.7b01420 | ||
| 70887131 | 170683 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 346 | 4 | 3 | 3 | 4.0 | O=C(NCCc1ccc2c(n1)NCCC2)Nc1cccc2ccccc12 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL4207204 | 170683 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 346 | 4 | 3 | 3 | 4.0 | O=C(NCCc1ccc2c(n1)NCCC2)Nc1cccc2ccccc12 | 10.1016/j.ejmech.2018.02.043 | ||
| 70887095 | 171074 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 364 | 4 | 3 | 3 | 3.8 | O=C(NCCc1ccc2c(n1)NCCC2)Nc1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL4212087 | 171074 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 364 | 4 | 3 | 3 | 3.8 | O=C(NCCc1ccc2c(n1)NCCC2)Nc1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2018.02.043 | ||
| 60202254 | 114299 | 4 | None | - | 1 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)NC2CC3CCCC(C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | nan | ||
| CHEMBL3186994 | 114299 | 4 | None | - | 1 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)NC2CC3CCCC(C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | nan | ||
| 145959142 | 168840 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 419 | 4 | 2 | 5 | 3.3 | C[C@H]1CN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)C[C@@H](C)N1 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4160496 | 168840 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 419 | 4 | 2 | 5 | 3.3 | C[C@H]1CN(c2cccc3c2C[C@H](CN(C)[C@H]2CCCc4cccnc42)NC3)C[C@@H](C)N1 | 10.1021/acs.jmedchem.8b00450 | ||
| 59176434 | 156499 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 558 | 9 | 1 | 7 | 3.8 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CC[S+]([O-])CC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3947926 | 156499 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 558 | 9 | 1 | 7 | 3.8 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CC[S+]([O-])CC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 135313576 | 169327 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 338 | 8 | 2 | 4 | 2.9 | C[C@@H](c1ccccn1)N(CCCCN)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4168126 | 169327 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 338 | 8 | 2 | 4 | 2.9 | C[C@@H](c1ccccn1)N(CCCCN)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 145963537 | 168812 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 461 | 8 | 1 | 5 | 3.9 | CC(C)N1CCN(CCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4159991 | 168812 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 461 | 8 | 1 | 5 | 3.9 | CC(C)N1CCN(CCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.8b00030 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| 59176438 | 156637 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 595 | 9 | 0 | 8 | 4.0 | CN1CCN(CCCN(Cc2nccc3c4ccccc4n(CC(=O)N4CCOCC4)c23)[C@H]2CCCc3cccnc32)CC1 | nan | ||
| CHEMBL3949024 | 156637 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 595 | 9 | 0 | 8 | 4.0 | CN1CCN(CCCN(Cc2nccc3c4ccccc4n(CC(=O)N4CCOCC4)c23)[C@H]2CCCc3cccnc32)CC1 | nan | ||
| 53319746 | 65162 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.2 | CC(C)c1cccnc1CN(CCCCN)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682864 | 65162 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 352 | 8 | 1 | 4 | 4.2 | CC(C)c1cccnc1CN(CCCCN)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| 70924198 | 149559 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 511 | 10 | 2 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CCN3CCNCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3892756 | 149559 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 511 | 10 | 2 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CCN3CCNCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 137641652 | 165107 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 447 | 9 | 3 | 5 | 3.6 | c1ccc2c(c1)CN[C@@H](CN(CCCCNC1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4089307 | 165107 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 447 | 9 | 3 | 5 | 3.6 | c1ccc2c(c1)CN[C@@H](CN(CCCCNC1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| 135314326 | 168943 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 358 | 8 | 2 | 4 | 3.0 | NCCCCN(Cc1ccc(Cl)cn1)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4162203 | 168943 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 358 | 8 | 2 | 4 | 3.0 | NCCCCN(Cc1ccc(Cl)cn1)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 135314329 | 165983 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 472 | 8 | 2 | 4 | 5.6 | CC1(C)CCC(NC/C=C/CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4098635 | 165983 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 472 | 8 | 2 | 4 | 5.6 | CC1(C)CCC(NC/C=C/CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 145957365 | 168777 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 390 | 5 | 2 | 4 | 3.5 | c1ccc2c(c1)CN[C@@H](CN(CC1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4159410 | 168777 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 390 | 5 | 2 | 4 | 3.5 | c1ccc2c(c1)CN[C@@H](CN(CC1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| 145958093 | 168759 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 433 | 8 | 2 | 5 | 3.2 | c1ccc2c(c1)CN[C@@H](CN(CCCCN1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4159150 | 168759 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 433 | 8 | 2 | 5 | 3.2 | c1ccc2c(c1)CN[C@@H](CN(CCCCN1CCNCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acsmedchemlett.8b00030 | ||
| 25177629 | 65205 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 298 | 8 | 1 | 4 | 3.1 | Cc1ccc(CN(CCCCN)C(C)c2ccccn2)nc1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682990 | 65205 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 298 | 8 | 1 | 4 | 3.1 | Cc1ccc(CN(CCCCN)C(C)c2ccccn2)nc1 | 10.1016/j.bmcl.2011.01.021 | ||
| 72546062 | 110613 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 455 | 9 | 1 | 5 | 4.5 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1ccncc1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091690 | 110613 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 455 | 9 | 1 | 5 | 4.5 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1ccncc1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 135313618 | 162742 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 522 | 8 | 2 | 4 | 6.7 | CC1(C)CCC(NCc2ccc(CN(C[C@H]3Cc4ccccc4CN3)[C@H]3CCCc4cccnc43)cc2)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4061381 | 162742 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 522 | 8 | 2 | 4 | 6.7 | CC1(C)CCC(NCc2ccc(CN(C[C@H]3Cc4ccccc4CN3)[C@H]3CCCc4cccnc43)cc2)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 70924083 | 152062 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 525 | 9 | 2 | 7 | 3.6 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCNCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3913028 | 152062 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 525 | 9 | 2 | 7 | 3.6 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCNCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 137644335 | 164887 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 546 | 12 | 1 | 6 | 5.7 | c1ccc(CN(CCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)Cc2ccccn2)nc1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4086739 | 164887 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 546 | 12 | 1 | 6 | 5.7 | c1ccc(CN(CCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)Cc2ccccn2)nc1 | 10.1021/acs.jmedchem.7b01420 | ||
| 59176368 | 156455 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 571 | 9 | 0 | 6 | 6.8 | CC(C)CN(Cc1nccc2c3ccccc3n(CCCN3C(=O)c4ccccc4C3=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3947569 | 156455 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 571 | 9 | 0 | 6 | 6.8 | CC(C)CN(Cc1nccc2c3ccccc3n(CCCN3C(=O)c4ccccc4C3=O)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 70924077 | 158698 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 442 | 8 | 3 | 4 | 4.4 | NC(=O)NCCCCN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3966215 | 158698 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 442 | 8 | 3 | 4 | 4.4 | NC(=O)NCCCCN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| 491773 | 19600 | 1 | None | -67 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 455 | 12 | 1 | 3 | 4.8 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | ||
| CHEMBL1188399 | 19600 | 1 | None | -67 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 455 | 12 | 1 | 3 | 4.8 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | ||
| CHEMBL536288 | 19600 | 1 | None | -67 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 455 | 12 | 1 | 3 | 4.8 | CCCCN1C(=O)C(CC(C)C)NC(=O)C12CCN(CCCCCCc1ccccc1)CC2 | 10.1021/jm060051s | ||
| 145972313 | 171353 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)[C@@H]3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4215380 | 171353 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)[C@@H]3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 10308735 | 14499 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 335 | 6 | 2 | 4 | 3.2 | NCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1088912 | 14499 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 335 | 6 | 2 | 4 | 3.2 | NCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 71590395 | 171037 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 356 | 6 | 3 | 5 | 2.8 | COc1ccc(NC(=O)NCCc2ccc3c(n2)NCCC3)cc1OC | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL4211557 | 171037 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 356 | 6 | 3 | 5 | 2.8 | COc1ccc(NC(=O)NCCc2ccc3c(n2)NCCC3)cc1OC | 10.1016/j.ejmech.2018.02.043 | ||
| 135314305 | 169395 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 352 | 8 | 2 | 4 | 3.0 | Cc1cnc(CN(CCCCN)C[C@H]2Cc3ccccc3CN2)c(C)c1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4169334 | 169395 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 352 | 8 | 2 | 4 | 3.0 | Cc1cnc(CN(CCCCN)C[C@H]2Cc3ccccc3CN2)c(C)c1 | 10.1021/acsmedchemlett.7b00381 | ||
| 137657247 | 166525 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 392 | 7 | 2 | 4 | 3.9 | CC(C)(CN)CCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4104948 | 166525 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 392 | 7 | 2 | 4 | 3.9 | CC(C)(CN)CCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.7b01420 | ||
| 59176482 | 155276 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 4.7 | NCCCCN(Cc1cc2c(cn1)[nH]c1ccccc12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3938247 | 155276 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 4.7 | NCCCCN(Cc1cc2c(cn1)[nH]c1ccccc12)C1CCCc2cccnc21 | nan | ||
| 137634107 | 163109 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 478 | 10 | 2 | 5 | 5.0 | c1ccc2c(c1)CN[C@@H](CN(CCCCNCC1CCSCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4065751 | 163109 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 478 | 10 | 2 | 5 | 5.0 | c1ccc2c(c1)CN[C@@H](CN(CCCCNCC1CCSCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm100786g | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm100786g | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm100786g | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm100786g | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm100786g | ||
| 135313911 | 169168 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 338 | 8 | 2 | 4 | 2.6 | Cc1ccnc(CN(CCCCN)C[C@H]2Cc3ccccc3CN2)c1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4165634 | 169168 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 338 | 8 | 2 | 4 | 2.6 | Cc1ccnc(CN(CCCCN)C[C@H]2Cc3ccccc3CN2)c1 | 10.1021/acsmedchemlett.7b00381 | ||
| 70924166 | 156055 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 427 | 9 | 2 | 4 | 5.4 | CCNCCCCN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3944558 | 156055 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 427 | 9 | 2 | 4 | 5.4 | CCNCCCCN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| 57345320 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.7b00381 | ||
| 9882 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL3091687 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.7b00381 | ||
| 72546295 | 110606 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 406 | 9 | 2 | 4 | 4.3 | CC(C)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091682 | 110606 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 406 | 9 | 2 | 4 | 4.3 | CC(C)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 59176357 | 154900 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 456 | 10 | 2 | 6 | 4.6 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3935318 | 154900 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 456 | 10 | 2 | 6 | 4.6 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 11718722 | 23428 | 13 | None | -3 | 4 | Rhesus macaque | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| CHEMBL1242210 | 23428 | 13 | None | -3 | 4 | Rhesus macaque | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| 135314215 | 169833 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 338 | 8 | 2 | 4 | 2.6 | Cc1ccc(CN(CCCCN)C[C@H]2Cc3ccccc3CN2)nc1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4176238 | 169833 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 338 | 8 | 2 | 4 | 2.6 | Cc1ccc(CN(CCCCN)C[C@H]2Cc3ccccc3CN2)nc1 | 10.1021/acsmedchemlett.7b00381 | ||
| 122192966 | 130682 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 507 | 9 | 2 | 6 | 3.3 | NCCCCN(C[C@H]1CN(S(=O)(=O)c2ccc3ccccc3c2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627860 | 130682 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 507 | 9 | 2 | 6 | 3.3 | NCCCCN(C[C@H]1CN(S(=O)(=O)c2ccc3ccccc3c2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 145973146 | 169835 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 473 | 6 | 2 | 5 | 4.5 | c1cnc2c(c1)CCC[C@@H]2N(CC1CCCCC1)C[C@H]1Cc2c(cccc2N2CCNCC2)CN1 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4176285 | 169835 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 473 | 6 | 2 | 5 | 4.5 | c1cnc2c(c1)CCC[C@@H]2N(CC1CCCCC1)C[C@H]1Cc2c(cccc2N2CCNCC2)CN1 | 10.1021/acs.jmedchem.8b00450 | ||
| 25177632 | 65202 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 299 | 8 | 2 | 5 | 2.4 | CC(c1ccccn1)N(CCCCN)Cc1ncccc1N | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682987 | 65202 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 299 | 8 | 2 | 5 | 2.4 | CC(c1ccccn1)N(CCCCN)Cc1ncccc1N | 10.1016/j.bmcl.2011.01.021 | ||
| 70924138 | 158183 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 453 | 10 | 2 | 4 | 5.8 | c1cnc2c(c1)CCCC2N(CCCCNCC1CC1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| CHEMBL3961651 | 158183 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 453 | 10 | 2 | 4 | 5.8 | c1cnc2c(c1)CCCC2N(CCCCNCC1CC1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| 46888654 | 15844 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 310 | 7 | 1 | 4 | 3.1 | NCCCCN(Cc1ccccn1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1099015 | 15844 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 310 | 7 | 1 | 4 | 3.1 | NCCCCN(Cc1ccccn1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| 25178567 | 183636 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 380 | 8 | 1 | 5 | 4.8 | CCCCCCN/C(=N/C1CCCCC1)SCC1=CSC2=NCCN12 | 10.1021/jm801065q | ||
| CHEMBL461358 | 183636 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 380 | 8 | 1 | 5 | 4.8 | CCCCCCN/C(=N/C1CCCCC1)SCC1=CSC2=NCCN12 | 10.1021/jm801065q | ||
| 46204210 | 14501 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 377 | 9 | 2 | 4 | 4.4 | NCCCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1088916 | 14501 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 377 | 9 | 2 | 4 | 4.4 | NCCCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 137662026 | 165916 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 446 | 9 | 2 | 4 | 5.2 | c1ccc2c(c1)CN[C@@H](CN(CCCCNC1CCCCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4097946 | 165916 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 446 | 9 | 2 | 4 | 5.2 | c1ccc2c(c1)CN[C@@H](CN(CCCCNC1CCCCC1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| 146398388 | 192410 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 419 | 5 | 3 | 5 | 3.8 | CN(C[C@H]1Cc2c(cccc2N[C@H]2CC[C@H](N)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL4864332 | 192410 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 419 | 5 | 3 | 5 | 3.8 | CN(C[C@H]1Cc2c(cccc2N[C@H]2CC[C@H](N)CC2)CN1)[C@H]1CCCc2cccnc21 | 10.1021/acsmedchemlett.1c00449 | ||
| 46204208 | 14636 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 347 | 6 | 2 | 4 | 3.4 | NC/C=C\CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1089844 | 14636 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 347 | 6 | 2 | 4 | 3.4 | NC/C=C\CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 137634464 | 162561 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 474 | 9 | 2 | 4 | 5.8 | CC1(C)CCC(NCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4059462 | 162561 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 474 | 9 | 2 | 4 | 5.8 | CC1(C)CCC(NCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 59176602 | 160265 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 542 | 9 | 1 | 7 | 4.8 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCSCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3979637 | 160265 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 542 | 9 | 1 | 7 | 4.8 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCSCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 162670980 | 189630 | 0 | None | - | 1 | Human | 4.1 | pIC50 | = | 4.1 | Functional | ChEMBL | 778 | 21 | 5 | 11 | 3.3 | CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NC[C@H]1CC[C@H](/N=C(/NC2CCCCC2)SCC2=CSC3=NC(C)(C)CN23)CC1 | 10.1039/c9md00433e | ||
| CHEMBL4791514 | 189630 | 0 | None | - | 1 | Human | 4.1 | pIC50 | = | 4.1 | Functional | ChEMBL | 778 | 21 | 5 | 11 | 3.3 | CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NC[C@H]1CC[C@H](/N=C(/NC2CCCCC2)SCC2=CSC3=NC(C)(C)CN23)CC1 | 10.1039/c9md00433e | ||
| 53321041 | 65163 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 340 | 8 | 2 | 5 | 2.6 | NCCCCN(Cc1ncccc1CO)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682865 | 65163 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 340 | 8 | 2 | 5 | 2.6 | NCCCCN(Cc1ncccc1CO)C1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| 59176381 | 154093 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 526 | 9 | 1 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCOCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3929073 | 154093 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 526 | 9 | 1 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCOCC3)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 71456969 | 91202 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 414 | 12 | 2 | 4 | 4.4 | C[C@H]1CCCCN1CCCNCc1ccc(CNCCCN2CCCC[C@H]2C)cc1 | 10.1021/jm300862u | ||
| CHEMBL2170299 | 91202 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 414 | 12 | 2 | 4 | 4.4 | C[C@H]1CCCCN1CCCNCc1ccc(CNCCCN2CCCC[C@H]2C)cc1 | 10.1021/jm300862u | ||
| CHEMBL2219959 | 91202 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 414 | 12 | 2 | 4 | 4.4 | C[C@H]1CCCCN1CCCNCc1ccc(CNCCCN2CCCC[C@H]2C)cc1 | 10.1021/jm300862u | ||
| 25178565 | 183520 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL460298 | 183520 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| 53324136 | 65208 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 312 | 8 | 1 | 4 | 3.4 | Cc1ccnc(C(C)N(CCCCN)Cc2ncccc2C)c1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682993 | 65208 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 312 | 8 | 1 | 4 | 3.4 | Cc1ccnc(C(C)N(CCCCN)Cc2ncccc2C)c1 | 10.1016/j.bmcl.2011.01.021 | ||
| 72546294 | 110605 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 392 | 8 | 1 | 4 | 3.8 | CN(C)CCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091681 | 110605 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 392 | 8 | 1 | 4 | 3.8 | CN(C)CCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL2373002 | 217124 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | None | None | None | NCCCC[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)c2ccc3ccccc3c2)CSSC[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCN2C1=O | 10.1016/s0960-894x(01)00323-7 | ||||
| 145958111 | 168794 | 0 | None | 3 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 376 | 6 | 2 | 4 | 3.4 | C/C(=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)CN | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4159607 | 168794 | 0 | None | 3 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 376 | 6 | 2 | 4 | 3.4 | C/C(=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)CN | 10.1021/acsmedchemlett.7b00406 | ||
| 145950432 | 169731 | 0 | None | 120 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | C/C(CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)=C(\F)CN | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4174727 | 169731 | 0 | None | 120 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 394 | 6 | 2 | 4 | 3.7 | C/C(CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)=C(\F)CN | 10.1021/acsmedchemlett.7b00406 | ||
| 70887092 | 171427 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 338 | 5 | 3 | 3 | 3.9 | CC(C)c1ccccc1NC(=O)NCCc1ccc2c(n1)NCCC2 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL4216535 | 171427 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 338 | 5 | 3 | 3 | 3.9 | CC(C)c1ccccc1NC(=O)NCCc1ccc2c(n1)NCCC2 | 10.1016/j.ejmech.2018.02.043 | ||
| 25178350 | 196698 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 426 | 4 | 1 | 5 | 6.4 | c1ccc2c(c1)nc1scc(CS/C(=N\C3CCCCC3)NC3CCCCC3)n12 | 10.1021/jm801065q | ||
| CHEMBL516989 | 196698 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 426 | 4 | 1 | 5 | 6.4 | c1ccc2c(c1)nc1scc(CS/C(=N\C3CCCCC3)NC3CCCCC3)n12 | 10.1021/jm801065q | ||
| 135313963 | 165556 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 480 | 8 | 2 | 4 | 5.2 | FC1(F)CCC(NC/C=C/CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4094123 | 165556 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 480 | 8 | 2 | 4 | 5.2 | FC1(F)CCC(NC/C=C/CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 162666072 | 189080 | 0 | None | -141 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 979 | 21 | 7 | 15 | 2.2 | CC1(C)CN2C(CS/C(N)=N\[C@H]3CC[C@H](CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@@H]4CC[C@@]5(O)[C@H]6Cc7ccc(O)c8c7[C@@]5(CCN6CC5CC5)[C@H]4O8)CC3)=CSC2=N1 | 10.1021/acsmedchemlett.0c00444 | ||
| CHEMBL4784104 | 189080 | 0 | None | -141 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 979 | 21 | 7 | 15 | 2.2 | CC1(C)CN2C(CS/C(N)=N\[C@H]3CC[C@H](CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@@H]4CC[C@@]5(O)[C@H]6Cc7ccc(O)c8c7[C@@]5(CCN6CC5CC5)[C@H]4O8)CC3)=CSC2=N1 | 10.1021/acsmedchemlett.0c00444 | ||
| 137657547 | 166582 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 546 | 12 | 1 | 6 | 5.7 | c1ccc2c(c1)CN[C@@H](CN(CCCCN(Cc1ccncc1)Cc1ccncc1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4105591 | 166582 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 546 | 12 | 1 | 6 | 5.7 | c1ccc2c(c1)CN[C@@H](CN(CCCCN(Cc1ccncc1)Cc1ccncc1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| 59176609 | 157547 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 419 | 5 | 1 | 5 | 5.2 | c1ccc(Cn2c3ccccc3c3ccnc(CN[C@H]4CCCc5cccnc54)c32)nc1 | nan | ||
| CHEMBL3956464 | 157547 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 419 | 5 | 1 | 5 | 5.2 | c1ccc(Cn2c3ccccc3c3ccnc(CN[C@H]4CCCc5cccnc54)c32)nc1 | nan | ||
| 155537257 | 179046 | 0 | None | -2 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 438 | 8 | 1 | 6 | 5.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 | 10.1016/j.bmc.2019.115091 | ||
| CHEMBL4474605 | 179046 | 0 | None | -2 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 438 | 8 | 1 | 6 | 5.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2cc(C)ccc2o1 | 10.1016/j.bmc.2019.115091 | ||
| 59176628 | 149611 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 457 | 9 | 2 | 6 | 4.3 | NCCCCN(Cc1cc2c3ccccc3n(CC(=O)O)c2cn1)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3893088 | 149611 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 457 | 9 | 2 | 6 | 4.3 | NCCCCN(Cc1cc2c3ccccc3n(CC(=O)O)c2cn1)[C@H]1CCCc2cccnc21 | nan | ||
| 59176528 | 152667 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 617 | 12 | 1 | 8 | 5.3 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCCNCc3ccccn3)[C@H]3CCCc4cccnc43)c21)N1CCOCC1 | nan | ||
| CHEMBL3917679 | 152667 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 617 | 12 | 1 | 8 | 5.3 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCCNCc3ccccn3)[C@H]3CCCc4cccnc43)c21)N1CCOCC1 | nan | ||
| 10237323 | 15010 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 377 | 8 | 1 | 4 | 4.2 | CN(C)CCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1092301 | 15010 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 377 | 8 | 1 | 4 | 4.2 | CN(C)CCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 70924205 | 157859 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 454 | 7 | 2 | 5 | 4.3 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| CHEMBL3959017 | 157859 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 454 | 7 | 2 | 5 | 4.3 | c1cnc2c(c1)CCC[C@@H]2N(CCCN1CCNCC1)Cc1nccc2c1[nH]c1ccccc12 | nan | ||
| 155531953 | 178525 | 0 | None | -57 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 438 | 8 | 1 | 6 | 6.0 | CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2019.115091 | ||
| CHEMBL4467290 | 178525 | 0 | None | -57 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 438 | 8 | 1 | 6 | 6.0 | CCCCN(c1nc2ccccc2o1)[C@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2019.115091 | ||
| 59176445 | 157510 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 595 | 9 | 1 | 8 | 3.1 | O=C1CN(CCCN(Cc2nccc3c4ccccc4n(CC(=O)N4CCOCC4)c23)[C@H]2CCCc3cccnc32)CCN1 | nan | ||
| CHEMBL3956267 | 157510 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 595 | 9 | 1 | 8 | 3.1 | O=C1CN(CCCN(Cc2nccc3c4ccccc4n(CC(=O)N4CCOCC4)c23)[C@H]2CCCc3cccnc32)CCN1 | nan | ||
| 135313829 | 169551 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 374 | 8 | 2 | 4 | 3.5 | NCCCCN(Cc1nccc2ccccc12)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| CHEMBL4171868 | 169551 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 374 | 8 | 2 | 4 | 3.5 | NCCCCN(Cc1nccc2ccccc12)C[C@H]1Cc2ccccc2CN1 | 10.1021/acsmedchemlett.7b00381 | ||
| 155530073 | 178271 | 0 | None | -10 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 438 | 8 | 1 | 6 | 6.0 | CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2019.115091 | ||
| CHEMBL4463797 | 178271 | 0 | None | -10 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 438 | 8 | 1 | 6 | 6.0 | CCCCN(c1nc2ccccc2o1)C(C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2019.115091 | ||
| 155535518 | 178847 | 0 | None | -4 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 452 | 9 | 1 | 6 | 6.4 | CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2019.115091 | ||
| CHEMBL4472121 | 178847 | 0 | None | -4 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 452 | 9 | 1 | 6 | 6.4 | CCCCN(c1nc2ccccc2o1)C(CC)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2019.115091 | ||
| 59176531 | 157743 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 385 | 6 | 2 | 5 | 4.1 | NCCCn1c2ccccc2c2ccnc(CN[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3958178 | 157743 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 385 | 6 | 2 | 5 | 4.1 | NCCCn1c2ccccc2c2ccnc(CN[C@H]3CCCc4cccnc43)c21 | nan | ||
| 76324529 | 110607 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 455 | 10 | 2 | 5 | 4.4 | c1ccc(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)nc1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL3091683 | 110607 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 455 | 10 | 2 | 5 | 4.4 | c1ccc(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)nc1 | 10.1021/acs.jmedchem.7b01420 | ||
| 59176472 | 149212 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 511 | 9 | 2 | 7 | 3.2 | NC(=O)Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3890039 | 149212 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 511 | 9 | 2 | 7 | 3.2 | NC(=O)Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 59176556 | 154749 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 437 | 8 | 1 | 5 | 4.8 | C#CCn1c2ccccc2c2ccnc(CN(CCCCN)[C@H]3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3934072 | 154749 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 437 | 8 | 1 | 5 | 4.8 | C#CCn1c2ccccc2c2ccnc(CN(CCCCN)[C@H]3CCCc4cccnc43)c21 | nan | ||
| 137655938 | 165763 | 0 | None | 64 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 362 | 6 | 2 | 4 | 3.0 | NC/C=C\CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4096305 | 165763 | 0 | None | 64 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 362 | 6 | 2 | 4 | 3.0 | NC/C=C\CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/acs.jmedchem.7b01420 | ||
| 146398485 | 192286 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 431 | 4 | 1 | 5 | 3.1 | CN1C[C@H]2CN(c3cccc4c3C[C@H](CN(C)[C@H]3CCCc5cccnc53)NC4)C[C@H]2C1 | 10.1021/acsmedchemlett.1c00449 | ||
| CHEMBL4862509 | 192286 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 431 | 4 | 1 | 5 | 3.1 | CN1C[C@H]2CN(c3cccc4c3C[C@H](CN(C)[C@H]3CCCc5cccnc53)NC4)C[C@H]2C1 | 10.1021/acsmedchemlett.1c00449 | ||
| 135314337 | 165127 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 496 | 8 | 2 | 5 | 4.9 | c1ccc2c(c1)CN[C@@H](CN(Cc1ccc(CNC3CCOCC3)cc1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4089531 | 165127 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 496 | 8 | 2 | 5 | 4.9 | c1ccc2c(c1)CN[C@@H](CN(Cc1ccc(CNC3CCOCC3)cc1)[C@H]1CCCc3cccnc31)C2 | 10.1021/acs.jmedchem.7b01420 | ||
| 53319745 | 65153 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.4 | Cc1ccnc(CN(CCCCN)C2CCCc3cccnc32)c1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682855 | 65153 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 324 | 7 | 1 | 4 | 3.4 | Cc1ccnc(CN(CCCCN)C2CCCc3cccnc32)c1 | 10.1016/j.bmcl.2011.01.021 | ||
| 135314107 | 169410 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 365 | 5 | 2 | 5 | 1.9 | Cc1cccnc1CN(C)C[C@H]1Cc2c(cccc2N2CCNCC2)CN1 | 10.1021/acs.jmedchem.8b00450 | ||
| CHEMBL4169504 | 169410 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 365 | 5 | 2 | 5 | 1.9 | Cc1cccnc1CN(C)C[C@H]1Cc2c(cccc2N2CCNCC2)CN1 | 10.1021/acs.jmedchem.8b00450 | ||
| 25178764 | 183546 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 380 | 4 | 1 | 5 | 4.5 | C/N=c1/scc(CS/C(=N\C2CCCCC2)NC2CCCCC2)n1C | 10.1021/jm801065q | ||
| CHEMBL460484 | 183546 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 380 | 4 | 1 | 5 | 4.5 | C/N=c1/scc(CS/C(=N\C2CCCCC2)NC2CCCCC2)n1C | 10.1021/jm801065q | ||
| 45182189 | 145610 | 1 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 399 | 8 | 1 | 4 | 4.3 | Oc1cccc(CN(CCN2CCCCC2)CC2CCCN(C3CCCC3)C2)c1 | 10.1021/acs.jmedchem.5b00497 | ||
| CHEMBL3781301 | 145610 | 1 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 399 | 8 | 1 | 4 | 4.3 | Oc1cccc(CN(CCN2CCCCC2)CC2CCCN(C3CCCC3)C2)c1 | 10.1021/acs.jmedchem.5b00497 | ||
| 45182189 | 145610 | 1 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 399 | 8 | 1 | 4 | 4.3 | Oc1cccc(CN(CCN2CCCCC2)CC2CCCN(C3CCCC3)C2)c1 | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL3781301 | 145610 | 1 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 399 | 8 | 1 | 4 | 4.3 | Oc1cccc(CN(CCN2CCCCC2)CC2CCCN(C3CCCC3)C2)c1 | 10.1016/j.ejmech.2017.08.027 | ||
| 135314252 | 163173 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 453 | 9 | 2 | 5 | 4.2 | C(=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)\CNCc1cccnc1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4066459 | 163173 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 453 | 9 | 2 | 5 | 4.2 | C(=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)\CNCc1cccnc1 | 10.1021/acs.jmedchem.7b01420 | ||
| 25181075 | 180204 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 392 | 4 | 0 | 5 | 4.9 | CN(/C(=N/C1CCCCC1)SCC1=CSC2=NCCN12)C1CCCCC1 | 10.1021/jm801065q | ||
| CHEMBL452868 | 180204 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 392 | 4 | 0 | 5 | 4.9 | CN(/C(=N/C1CCCCC1)SCC1=CSC2=NCCN12)C1CCCCC1 | 10.1021/jm801065q | ||
| 70924239 | 151559 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 397 | 6 | 2 | 4 | 4.5 | NC/C=C\CN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3909203 | 151559 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 397 | 6 | 2 | 4 | 4.5 | NC/C=C\CN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| 59176632 | 159681 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 513 | 9 | 1 | 7 | 5.5 | CC(C)(C)OC(=O)Cn1c2ccccc2c2cc(CN(CCCCN)[C@H]3CCCc4cccnc43)ncc21 | nan | ||
| CHEMBL3974711 | 159681 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 513 | 9 | 1 | 7 | 5.5 | CC(C)(C)OC(=O)Cn1c2ccccc2c2cc(CN(CCCCN)[C@H]3CCCc4cccnc43)ncc21 | nan | ||
| 70924094 | 153640 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 499 | 8 | 2 | 6 | 5.4 | CC(C)(C)OC(=O)[C@@H](N)CCCN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3925239 | 153640 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 499 | 8 | 2 | 6 | 5.4 | CC(C)(C)OC(=O)[C@@H](N)CCCN(Cc1nccc2c1[nH]c1ccccc12)[C@H]1CCCc2cccnc21 | nan | ||
| 145961863 | 168843 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 462 | 7 | 2 | 5 | 2.6 | NC(=O)N1CCN(CCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.8b00030 | ||
| CHEMBL4160551 | 168843 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 462 | 7 | 2 | 5 | 2.6 | NC(=O)N1CCN(CCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.8b00030 | ||
| 155554813 | 181183 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 458 | 7 | 1 | 6 | 5.9 | c1ccc(CN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2nc3ccccc3o2)cc1 | 10.1016/j.bmc.2019.115091 | ||
| CHEMBL4552485 | 181183 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 458 | 7 | 1 | 6 | 5.9 | c1ccc(CN(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2nc3ccccc3o2)cc1 | 10.1016/j.bmc.2019.115091 | ||
| CHEMBL1956254 | 215882 | 1 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmcl.2012.01.134 | ||||
| 155518713 | 177059 | 0 | None | -2 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 424 | 8 | 1 | 6 | 5.5 | CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 | 10.1016/j.bmc.2019.115091 | ||
| CHEMBL4446260 | 177059 | 0 | None | -2 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 424 | 8 | 1 | 6 | 5.5 | CCCCN(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1nc2ccccc2o1 | 10.1016/j.bmc.2019.115091 | ||
| 10215423 | 14638 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 345 | 4 | 2 | 4 | 2.8 | NCC#CCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1089846 | 14638 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 345 | 4 | 2 | 4 | 2.8 | NCC#CCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 142416754 | 169121 | 0 | None | 112 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 480 | 8 | 2 | 4 | 5.2 | FC1(F)CCC(NC/C=C\CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.7b00406 | ||
| CHEMBL4164874 | 169121 | 0 | None | 112 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 480 | 8 | 2 | 4 | 5.2 | FC1(F)CCC(NC/C=C\CN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)CC1 | 10.1021/acsmedchemlett.7b00406 | ||
| 155525712 | 177854 | 0 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 438 | 8 | 1 | 6 | 6.0 | CCCCN(c1nc2ccccc2o1)[C@@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2019.115091 | ||
| CHEMBL4457246 | 177854 | 0 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 438 | 8 | 1 | 6 | 6.0 | CCCCN(c1nc2ccccc2o1)[C@@H](C)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2019.115091 | ||
| 59176463 | 152478 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 4.8 | CCN(Cc1nccc2c3ccccc3n(CCCN)c12)[C@H]1CCCc2cccnc21 | nan | ||
| CHEMBL3916239 | 152478 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 4.8 | CCN(Cc1nccc2c3ccccc3n(CCCN)c12)[C@H]1CCCc2cccnc21 | nan | ||
| 70924194 | 151713 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 518 | 7 | 1 | 6 | 3.6 | CS(=O)(=O)N1CCN(CCN(Cc2nccc3c2[nH]c2ccccc23)C2CCCc3cccnc32)CC1 | nan | ||
| CHEMBL3910316 | 151713 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 518 | 7 | 1 | 6 | 3.6 | CS(=O)(=O)N1CCN(CCN(Cc2nccc3c2[nH]c2ccccc23)C2CCCc3cccnc32)CC1 | nan | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 5.0 | pKi | = | 5.0 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 5.0 | pKi | = | 5.0 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 4.9 | pKi | = | 4.9 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 4.9 | pKi | = | 4.9 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 4.9 | pKi | = | 4.9 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 4.9 | pKi | = | 4.9 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 4.9 | pKi | = | 4.9 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 4.9 | pKi | = | 4.9 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 4.8 | pKi | = | 4.8 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 4.8 | pKi | = | 4.8 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 4.8 | pKi | = | 4.8 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 4.8 | pKi | = | 4.8 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 4.7 | pKi | = | 4.7 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 4.7 | pKi | = | 4.7 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 4.7 | pKi | = | 4.7 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 4.7 | pKi | = | 4.7 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 4.6 | pKi | = | 4.6 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 4.6 | pKi | = | 4.6 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 4.6 | pKi | = | 4.6 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 4.6 | pKi | = | 4.6 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 4.5 | pKi | = | 4.5 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 4.5 | pKi | = | 4.5 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 4.4 | pKi | = | 4.4 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 4.4 | pKi | = | 4.4 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 5.3 | pKi | = | 5.3 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 5.3 | pKi | = | 5.3 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 5.3 | pKi | = | 5.3 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 5.3 | pKi | = | 5.3 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 5.3 | pKi | = | 5.3 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 4.2 | pKi | = | 4.2 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 4.2 | pKi | = | 4.2 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 0 | Human | 4.1 | pKi | = | 4.1 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 0 | Human | 4.1 | pKi | = | 4.1 | Functional | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 5.1 | pKi | = | 5.1 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 483570 | 188871 | 1 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | -316 | 6 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | -316 | 6 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | -316 | 6 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | -316 | 6 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | -316 | 6 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 9161 | 10709 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| 11176403 | 8874 | 1 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | Guide to Pharmacology | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 19053768 | ||
| 2900 | 8874 | 1 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | Guide to Pharmacology | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 19053768 | ||
| CHEMBL452864 | 8874 | 1 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | Guide to Pharmacology | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 19053768 | ||
| 25147749 | 8875 | 18 | None | -18 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | Guide to Pharmacology | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 19053768 | ||
| 2899 | 8875 | 18 | None | -18 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | Guide to Pharmacology | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 19053768 | ||
| CHEMBL460491 | 8875 | 18 | None | -18 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | Guide to Pharmacology | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 19053768 | ||
| 133081963 | 7885 | 0 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | Guide to Pharmacology | 446 | 8 | 2 | 5 | 3.8 | O1CCC(CC1)NC/C=C/CN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 29350534 | ||
| 9883 | 7885 | 0 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | Guide to Pharmacology | 446 | 8 | 2 | 5 | 3.8 | O1CCC(CC1)NC/C=C/CN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 29350534 | ||
| CHEMBL4075205 | 7885 | 0 | None | -1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | Guide to Pharmacology | 446 | 8 | 2 | 5 | 3.8 | O1CCC(CC1)NC/C=C/CN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 29350534 | ||
| 57345320 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 29350534 | ||
| 9882 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 29350534 | ||
| CHEMBL3091687 | 10604 | 9 | None | 34 | 7 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 29350534 | ||
| 25077385 | 7160 | 0 | None | 3 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | Guide to Pharmacology | None | None | None | None | 11923301 | ||||
| 607 | 7160 | 0 | None | 3 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | Guide to Pharmacology | None | None | None | None | 11923301 | ||||
| 11176403 | 8874 | 1 | None | -1 | 2 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | Guide to Pharmacology | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 19053768 | ||
| 2900 | 8874 | 1 | None | -1 | 2 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | Guide to Pharmacology | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 19053768 | ||
| CHEMBL452864 | 8874 | 1 | None | -1 | 2 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | Guide to Pharmacology | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 19053768 | ||
| 11176403 | 8874 | 1 | None | 1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | Guide to Pharmacology | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 19053768 | ||
| 2900 | 8874 | 1 | None | 1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | Guide to Pharmacology | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 19053768 | ||
| CHEMBL452864 | 8874 | 1 | None | 1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | Guide to Pharmacology | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 19053768 | ||
| 25147749 | 8875 | 18 | None | 18 | 2 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 19053768 | ||
| 2899 | 8875 | 18 | None | 18 | 2 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 19053768 | ||
| CHEMBL460491 | 8875 | 18 | None | 18 | 2 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 19053768 | ||
| 133081963 | 7885 | 0 | None | 1 | 2 | Mouse | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 446 | 8 | 2 | 5 | 3.8 | O1CCC(CC1)NC/C=C/CN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 29350534 | ||
| 9883 | 7885 | 0 | None | 1 | 2 | Mouse | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 446 | 8 | 2 | 5 | 3.8 | O1CCC(CC1)NC/C=C/CN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 29350534 | ||
| CHEMBL4075205 | 7885 | 0 | None | 1 | 2 | Mouse | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 446 | 8 | 2 | 5 | 3.8 | O1CCC(CC1)NC/C=C/CN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 29350534 | ||
| 25147749 | 8875 | 18 | None | -18 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 19053768 | ||
| 25147749 | 8875 | 18 | None | -18 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 30476826 | ||
| 2899 | 8875 | 18 | None | -18 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 19053768 | ||
| 2899 | 8875 | 18 | None | -18 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 30476826 | ||
| CHEMBL460491 | 8875 | 18 | None | -18 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 19053768 | ||
| CHEMBL460491 | 8875 | 18 | None | -18 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 30476826 | ||
| 16197445 | 10494 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 9918823 | ||||
| 852 | 10494 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 9918823 | ||||
| 16197316 | 10498 | 0 | None | - | 1 | Human | 7.3 | pIC50 | None | 7.3 | Functional | Guide to Pharmacology | None | None | None | None | 9918823 | ||||
| 56947145 | 10498 | 0 | None | - | 1 | Human | 7.3 | pIC50 | None | 7.3 | Functional | Guide to Pharmacology | None | None | None | None | 9918823 | ||||
| 854 | 10498 | 0 | None | - | 1 | Human | 7.3 | pIC50 | None | 7.3 | Functional | Guide to Pharmacology | None | None | None | None | 9918823 | ||||
| 16130395 | 10495 | 16 | None | - | 1 | Human | 8.2 | pIC50 | None | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 11923301 | ||||
| 16130395 | 10495 | 16 | None | - | 1 | Human | 8.2 | pIC50 | None | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 9918823 | ||||
| 56947144 | 10495 | 16 | None | - | 1 | Human | 8.2 | pIC50 | None | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 11923301 | ||||
| 56947144 | 10495 | 16 | None | - | 1 | Human | 8.2 | pIC50 | None | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 9918823 | ||||
| 73345443 | 10495 | 16 | None | - | 1 | Human | 8.2 | pIC50 | None | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 11923301 | ||||
| 73345443 | 10495 | 16 | None | - | 1 | Human | 8.2 | pIC50 | None | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 9918823 | ||||
| 853 | 10495 | 16 | None | - | 1 | Human | 8.2 | pIC50 | None | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 11923301 | ||||
| 853 | 10495 | 16 | None | - | 1 | Human | 8.2 | pIC50 | None | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 9918823 | ||||
| CHEMBL2370138 | 10495 | 16 | None | - | 1 | Human | 8.2 | pIC50 | None | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 11923301 | ||||
| CHEMBL2370138 | 10495 | 16 | None | - | 1 | Human | 8.2 | pIC50 | None | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 9918823 | ||||
| 486830 | 10774 | 0 | None | -7 | 5 | Human | 8.2 | pIC50 | None | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 9287217 | ||||
| 768 | 10774 | 0 | None | -7 | 5 | Human | 8.2 | pIC50 | None | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 9287217 | ||||
| 118965258 | 8010 | 0 | None | - | 1 | Human | 7.3 | pIC50 | ~ | 7.3 | Functional | Guide to Pharmacology | 649 | 18 | 6 | 12 | 2.7 | OC(=O)[C@H](CCC(=O)N1CCC(CC1)Nc1nc(NCc2nnn(c2)CCCNCCCNC2CCCCC2)nc2c1cccc2)N | 27938478 | ||
| 9701 | 8010 | 0 | None | - | 1 | Human | 7.3 | pIC50 | ~ | 7.3 | Functional | Guide to Pharmacology | 649 | 18 | 6 | 12 | 2.7 | OC(=O)[C@H](CCC(=O)N1CCC(CC1)Nc1nc(NCc2nnn(c2)CCCNCCCNC2CCCCC2)nc2c1cccc2)N | 27938478 | ||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 11565518 | 96659 | 89 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | ChEMBL | 290 | 6 | 2 | 4 | 3.7 | c1ccc(NCc2ccc(CNc3ccccn3)cc2)nc1 | 10.1021/jm070679i | ||
| CHEMBL237830 | 96659 | 89 | None | - | 0 | Human | 9.5 | pEC50 | = | 9.5 | Binding | ChEMBL | 290 | 6 | 2 | 4 | 3.7 | c1ccc(NCc2ccc(CNc3ccccn3)cc2)nc1 | 10.1021/jm070679i | ||
| 134143183 | 152005 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 3080 | 81 | 50 | 42 | -10.0 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC(CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3912645 | 152005 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 3080 | 81 | 50 | 42 | -10.0 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC(CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| 118965395 | 162992 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 613 | 19 | 6 | 12 | 1.7 | Cc1cc(NC2CCN(C(=O)CCNCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4064397 | 162992 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 613 | 19 | 6 | 12 | 1.7 | Cc1cc(NC2CCN(C(=O)CCNCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL3924080 | 219235 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL3905094 | 219221 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL3982241 | 219299 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL3974242 | 219284 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 52945183 | 23989 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 2648 | 62 | 39 | 31 | -3.3 | N=C(N)NCCC[C@H](NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| 91933416 | 23989 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 2648 | 62 | 39 | 31 | -3.3 | N=C(N)NCCC[C@H](NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| CHEMBL1256529 | 23989 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 2648 | 62 | 39 | 31 | -3.3 | N=C(N)NCCC[C@H](NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| 45182189 | 145610 | 1 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 399 | 8 | 1 | 4 | 4.3 | Oc1cccc(CN(CCN2CCCCC2)CC2CCCN(C3CCCC3)C2)c1 | 10.1016/j.ejmech.2016.02.051 | ||
| CHEMBL3781301 | 145610 | 1 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 399 | 8 | 1 | 4 | 4.3 | Oc1cccc(CN(CCN2CCCCC2)CC2CCCN(C3CCCC3)C2)c1 | 10.1016/j.ejmech.2016.02.051 | ||
| 134139386 | 153357 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 3137 | 86 | 45 | 43 | -6.4 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3923006 | 153357 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 3137 | 86 | 45 | 43 | -6.4 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| 52948854 | 23988 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 2620 | 60 | 39 | 31 | -4.0 | N=C(N)NCCCC(NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| 91933415 | 23988 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 2620 | 60 | 39 | 31 | -4.0 | N=C(N)NCCCC(NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| CHEMBL1256528 | 23988 | 0 | None | - | 0 | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 2620 | 60 | 39 | 31 | -4.0 | N=C(N)NCCCC(NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| CHEMBL3914095 | 219228 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 52942784 | 23990 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 2676 | 64 | 39 | 31 | -2.5 | N=C(N)NCCC[C@H](NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| 91933417 | 23990 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 2676 | 64 | 39 | 31 | -2.5 | N=C(N)NCCC[C@H](NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| CHEMBL1256530 | 23990 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 2676 | 64 | 39 | 31 | -2.5 | N=C(N)NCCC[C@H](NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| CHEMBL1256583 | 23990 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 2676 | 64 | 39 | 31 | -2.5 | N=C(N)NCCC[C@H](NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| 134138747 | 154234 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 3170 | 84 | 51 | 43 | -9.6 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C/C=C/c1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3930215 | 154234 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 3170 | 84 | 51 | 43 | -9.6 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C/C=C/c1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3903301 | 219220 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 56750906 | 129775 | 6 | None | - | 0 | Human | 4.3 | pEC50 | = | 4.3 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.8 | c1ccc(Cc2cn[nH]c2C2CCN(Cc3ccncc3)CC2)cc1 | 10.1021/acsmedchemlett.5b00036 | ||
| CHEMBL3608763 | 129775 | 6 | None | - | 0 | Human | 4.3 | pEC50 | = | 4.3 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.8 | c1ccc(Cc2cn[nH]c2C2CCN(Cc3ccncc3)CC2)cc1 | 10.1021/acsmedchemlett.5b00036 | ||
| CHEMBL3896146 | 219207 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL3976727 | 219287 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 134150065 | 158429 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 2985 | 83 | 45 | 42 | -8.2 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3963915 | 158429 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 2985 | 83 | 45 | 42 | -8.2 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| 134134119 | 149949 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 3125 | 83 | 50 | 44 | -10.8 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3896065 | 149949 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 3125 | 83 | 50 | 44 | -10.8 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| 134132933 | 151954 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 3169 | 82 | 52 | 43 | -9.8 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)c1cc2ccccc2[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3912312 | 151954 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 3169 | 82 | 52 | 43 | -9.8 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)c1cc2ccccc2[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3978794 | 219290 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 2719 | 7704 | 74 | None | - | 11 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 319 | 8 | 1 | 3 | 4.8 | CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC | 10.1016/j.ejmech.2018.08.028 | ||
| 5535 | 7704 | 74 | None | - | 11 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 319 | 8 | 1 | 3 | 4.8 | CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC | 10.1016/j.ejmech.2018.08.028 | ||
| 607 | 7704 | 74 | None | - | 11 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 319 | 8 | 1 | 3 | 4.8 | CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC | 10.1016/j.ejmech.2018.08.028 | ||
| CHEMBL76 | 7704 | 74 | None | - | 11 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 319 | 8 | 1 | 3 | 4.8 | CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC | 10.1016/j.ejmech.2018.08.028 | ||
| DB00608 | 7704 | 74 | None | - | 11 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 319 | 8 | 1 | 3 | 4.8 | CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC | 10.1016/j.ejmech.2018.08.028 | ||
| 56955853 | 145502 | 1 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 501 | 12 | 5 | 7 | 4.8 | c1ccc2c(NC3CCNCC3)nc(NCc3ccc(CNCCCNC4CCCCC4)cc3)nc2c1 | 10.1016/j.ejmech.2016.02.051 | ||
| CHEMBL3779982 | 145502 | 1 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 501 | 12 | 5 | 7 | 4.8 | c1ccc2c(NC3CCNCC3)nc(NCc3ccc(CNCCCNC4CCCCC4)cc3)nc2c1 | 10.1016/j.ejmech.2016.02.051 | ||
| 52942784 | 23990 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 2676 | 64 | 39 | 31 | -2.5 | N=C(N)NCCC[C@H](NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| 91933417 | 23990 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 2676 | 64 | 39 | 31 | -2.5 | N=C(N)NCCC[C@H](NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| CHEMBL1256530 | 23990 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 2676 | 64 | 39 | 31 | -2.5 | N=C(N)NCCC[C@H](NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| CHEMBL1256583 | 23990 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 2676 | 64 | 39 | 31 | -2.5 | N=C(N)NCCC[C@H](NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c2ccc(F)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCNC(=O)CCC(=O)NCCCCCCCCN2CCC(NC(=O)C(=O)Nc3ccc(Cl)cc3)CC2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N1)C(N)=O | 10.1016/j.bmcl.2010.07.106 | ||
| 56750906 | 129775 | 6 | None | - | 0 | Human | 4.2 | pEC50 | = | 4.2 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.8 | c1ccc(Cc2cn[nH]c2C2CCN(Cc3ccncc3)CC2)cc1 | 10.1021/acsmedchemlett.5b00036 | ||
| CHEMBL3608763 | 129775 | 6 | None | - | 0 | Human | 4.2 | pEC50 | = | 4.2 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.8 | c1ccc(Cc2cn[nH]c2C2CCN(Cc3ccncc3)CC2)cc1 | 10.1021/acsmedchemlett.5b00036 | ||
| 134155140 | 157913 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 3268 | 83 | 51 | 43 | -7.5 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cc2cccc3ccc4cccc1c4c32)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3959440 | 157913 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 3268 | 83 | 51 | 43 | -7.5 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cc2cccc3ccc4cccc1c4c32)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3955461 | 219268 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 134135404 | 150712 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 3244 | 83 | 51 | 43 | -8.1 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc2cc3ccccc3cc2c1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3902240 | 150712 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 3244 | 83 | 51 | 43 | -8.1 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc2cc3ccccc3cc2c1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3940962 | 219249 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL3949729 | 219260 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL3924163 | 219236 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL3970509 | 219281 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 11565518 | 96659 | 89 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 290 | 6 | 2 | 4 | 3.7 | c1ccc(NCc2ccc(CNc3ccccn3)cc2)nc1 | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL237830 | 96659 | 89 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 290 | 6 | 2 | 4 | 3.7 | c1ccc(NCc2ccc(CNc3ccccn3)cc2)nc1 | 10.1016/j.ejmech.2017.08.027 | ||
| 11718722 | 23428 | 13 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| CHEMBL1242210 | 23428 | 13 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 420 | 5 | 1 | 7 | 2.5 | CN1CCN(c2cccc3nc(CN(C)[C@H]4CCCc5cccnc54)c(CO)n23)CC1 | 10.1128/aac.01293-09 | ||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL393882 | 219248 | 3 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm070679i | ||||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1016/j.ejmech.2018.02.043 | ||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m705302200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.6b01309 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.6b01309 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.6b01309 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.6b01309 | ||
| 49857485 | 70579 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 6 | 2 | 5 | 3.2 | Fc1ccc(NCc2ccc(CNc3ncccn3)cc2)nc1 | nan | ||
| CHEMBL1802286 | 70579 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 6 | 2 | 5 | 3.2 | Fc1ccc(NCc2ccc(CNc3ncccn3)cc2)nc1 | nan | ||
| 49857486 | 70580 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 6 | 2 | 5 | 3.2 | Fc1cccc(NCc2ccc(CNc3ncccn3)cc2)n1 | nan | ||
| CHEMBL1802287 | 70580 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 309 | 6 | 2 | 5 | 3.2 | Fc1cccc(NCc2ccc(CNc3ncccn3)cc2)n1 | nan | ||
| 49857488 | 70583 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 325 | 6 | 2 | 5 | 3.7 | Clc1cccc(NCc2ccc(CNc3ncccn3)cc2)n1 | nan | ||
| CHEMBL1802323 | 70583 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 325 | 6 | 2 | 5 | 3.7 | Clc1cccc(NCc2ccc(CNc3ncccn3)cc2)n1 | nan | ||
| 49857681 | 70586 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 328 | 6 | 2 | 6 | 2.8 | Fc1nccc(NCc2ccc(CNc3ccnc(F)n3)cc2)n1 | nan | ||
| CHEMBL1802330 | 70586 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 328 | 6 | 2 | 6 | 2.8 | Fc1nccc(NCc2ccc(CNc3ccnc(F)n3)cc2)n1 | nan | ||
| 23656764 | 96453 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 348 | 8 | 2 | 4 | 4.9 | COc1cccc(NCc2ccc(CNc3cccc(OC)c3)cc2)c1 | nan | ||
| CHEMBL237629 | 96453 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 348 | 8 | 2 | 4 | 4.9 | COc1cccc(NCc2ccc(CNc3cccc(OC)c3)cc2)c1 | nan | ||
| 58757240 | 149956 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 364 | 6 | 2 | 6 | 3.0 | Fc1cc(F)nc(NCc2ccc(CNc3nc(F)cc(F)n3)cc2)n1 | nan | ||
| CHEMBL3896101 | 149956 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 364 | 6 | 2 | 6 | 3.0 | Fc1cc(F)nc(NCc2ccc(CNc3nc(F)cc(F)n3)cc2)n1 | nan | ||
| 58757245 | 152040 | 1 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 258 | 5 | 2 | 4 | 2.7 | O=[N+]([O-])c1ccccc1NCc1ccc(CO)cc1 | nan | ||
| CHEMBL3912875 | 152040 | 1 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 258 | 5 | 2 | 4 | 2.7 | O=[N+]([O-])c1ccccc1NCc1ccc(CO)cc1 | nan | ||
| 8241714 | 153513 | 1 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 378 | 8 | 2 | 6 | 4.7 | O=[N+]([O-])c1cccc(NCc2ccc(CNc3cccc([N+](=O)[O-])c3)cc2)c1 | nan | ||
| CHEMBL392423 | 153513 | 1 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 378 | 8 | 2 | 6 | 4.7 | O=[N+]([O-])c1cccc(NCc2ccc(CNc3cccc([N+](=O)[O-])c3)cc2)c1 | nan | ||
| 58757241 | 158539 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 396 | 6 | 2 | 6 | 4.1 | Fc1cnc(NCc2ccc(CNc3ncc(F)c(Cl)n3)cc2)nc1Cl | nan | ||
| CHEMBL3964805 | 158539 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 396 | 6 | 2 | 6 | 4.1 | Fc1cnc(NCc2ccc(CNc3ncc(F)c(Cl)n3)cc2)nc1Cl | nan | ||
| 58757238 | 160951 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 217 | 4 | 1 | 3 | 2.6 | FCc1ccc(CNc2ncccn2)cc1 | nan | ||
| CHEMBL3985608 | 160951 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 217 | 4 | 1 | 3 | 2.6 | FCc1ccc(CNc2ncccn2)cc1 | nan | ||
| 58757235 | 161012 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 388 | 8 | 2 | 8 | 2.8 | COc1nc(NCc2ccc(CNc3ncc(F)c(OC)n3)cc2)ncc1F | nan | ||
| CHEMBL3986129 | 161012 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 388 | 8 | 2 | 8 | 2.8 | COc1nc(NCc2ccc(CNc3ncc(F)c(OC)n3)cc2)ncc1F | nan | ||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| 477104 | 123626 | 8 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 570 | 4 | 4 | 8 | 2.0 | c1cc2nc(c1)CCNCCN(Cc1ccc(CN3CCNCCc4cccc(n4)CCNCC3)cc1)CCNCC2 | 10.1021/jm990211i | ||
| CHEMBL1202231 | 123626 | 8 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 570 | 4 | 4 | 8 | 2.0 | c1cc2nc(c1)CCNCCN(Cc1ccc(CN3CCNCCc4cccc(n4)CCNCC3)cc1)CCNCC2 | 10.1021/jm990211i | ||
| CHEMBL338074 | 123626 | 8 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 570 | 4 | 4 | 8 | 2.0 | c1cc2nc(c1)CCNCCN(Cc1ccc(CN3CCNCCc4cccc(n4)CCNCC3)cc1)CCNCC2 | 10.1021/jm990211i | ||
| 25147749 | 8875 | 18 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acs.jmedchem.6b01309 | ||
| 2899 | 8875 | 18 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acs.jmedchem.6b01309 | ||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2012527 | 215899 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)CC1=O | 10.1021/ml200084n | ||||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| 137648951 | 164203 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 1019 | 18 | 14 | 12 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4078698 | 164203 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 1019 | 18 | 14 | 12 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL2012525 | 215897 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)CC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/ml200084n | ||||
| 155525671 | 177894 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 8 | 3 | 7 | 4.2 | c1ccc(CN(Cc2ccc3c(CN4CCCNCCNCCCNCC4)cccc3c2)Cc2ccccn2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| CHEMBL4457992 | 177894 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 8 | 3 | 7 | 4.2 | c1ccc(CN(Cc2ccc3c(CN4CCCNCCNCCCNCC4)cccc3c2)Cc2ccccn2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| 138501629 | 188485 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 380 | 5 | 0 | 6 | 2.8 | CCN1CCN(c2cc(CN(C)[C@H]3CCCc4cccnc43)nc(C)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4776865 | 188485 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 380 | 5 | 0 | 6 | 2.8 | CCN1CCN(c2cc(CN(C)[C@H]3CCCc4cccnc43)nc(C)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| 49857097 | 70576 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 430 | 6 | 2 | 8 | 3.9 | Clc1nc(Cl)nc(NCc2ccc(CNc3nc(Cl)nc(Cl)n3)cc2)n1 | nan | ||
| CHEMBL1802282 | 70576 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 430 | 6 | 2 | 8 | 3.9 | Clc1nc(Cl)nc(NCc2ccc(CNc3nc(Cl)nc(Cl)n3)cc2)n1 | nan | ||
| 49857287 | 70577 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 290 | 6 | 2 | 4 | 3.7 | c1ccc(NCc2ccc(CNc3ncccn3)cc2)cc1 | nan | ||
| CHEMBL1802283 | 70577 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 290 | 6 | 2 | 4 | 3.7 | c1ccc(NCc2ccc(CNc3ncccn3)cc2)cc1 | nan | ||
| 49857487 | 70582 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 325 | 6 | 2 | 5 | 3.7 | Clc1ccc(NCc2ccc(CNc3ncccn3)cc2)nc1 | nan | ||
| CHEMBL1802322 | 70582 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 325 | 6 | 2 | 5 | 3.7 | Clc1ccc(NCc2ccc(CNc3ncccn3)cc2)nc1 | nan | ||
| 23656445 | 95324 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 344 | 6 | 2 | 2 | 6.1 | Cc1c(C)c(CNc2ccccc2)c(C)c(C)c1CNc1ccccc1 | nan | ||
| CHEMBL235310 | 95324 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 344 | 6 | 2 | 2 | 6.1 | Cc1c(C)c(CNc2ccccc2)c(C)c(C)c1CNc1ccccc1 | nan | ||
| 3313778 | 96323 | 4 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 316 | 6 | 2 | 2 | 5.5 | Cc1ccc(NCc2ccc(CNc3ccc(C)cc3)cc2)cc1 | nan | ||
| CHEMBL237439 | 96323 | 4 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 316 | 6 | 2 | 2 | 5.5 | Cc1ccc(NCc2ccc(CNc3ccc(C)cc3)cc2)cc1 | nan | ||
| 328731 | 96334 | 5 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 344 | 8 | 2 | 2 | 6.0 | CCc1ccc(NCc2ccc(CNc3ccc(CC)cc3)cc2)cc1 | nan | ||
| CHEMBL237440 | 96334 | 5 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 344 | 8 | 2 | 2 | 6.0 | CCc1ccc(NCc2ccc(CNc3ccc(CC)cc3)cc2)cc1 | nan | ||
| 8241537 | 96658 | 1 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 348 | 8 | 2 | 4 | 4.9 | COc1ccccc1NCc1ccc(CNc2ccccc2OC)cc1 | nan | ||
| CHEMBL237829 | 96658 | 1 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 348 | 8 | 2 | 4 | 4.9 | COc1ccccc1NCc1ccc(CNc2ccccc2OC)cc1 | nan | ||
| 58757230 | 151622 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 352 | 8 | 2 | 8 | 2.5 | COc1ccnc(NCc2ccc(CNc3nccc(OC)n3)cc2)n1 | nan | ||
| CHEMBL3909689 | 151622 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 352 | 8 | 2 | 8 | 2.5 | COc1ccnc(NCc2ccc(CNc3nccc(OC)n3)cc2)n1 | nan | ||
| 58757229 | 154565 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 290 | 6 | 2 | 4 | 3.7 | c1cncc(NCc2ccc(CNc3cccnc3)cc2)c1 | nan | ||
| CHEMBL3932667 | 154565 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 290 | 6 | 2 | 4 | 3.7 | c1cncc(NCc2ccc(CNc3cccnc3)cc2)c1 | nan | ||
| 24804043 | 157726 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 291 | 6 | 1 | 4 | 3.7 | c1ccc(OCc2ccc(CNc3ncccn3)cc2)cc1 | nan | ||
| CHEMBL3958019 | 157726 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 291 | 6 | 1 | 4 | 3.7 | c1ccc(OCc2ccc(CNc3ncccn3)cc2)cc1 | nan | ||
| 155546592 | 180316 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 551 | 8 | 3 | 7 | 4.2 | c1ccc(CN(Cc2ccc3cc(CN4CCCNCCNCCCNCC4)ccc3c2)Cc2ccccn2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| CHEMBL4531581 | 180316 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 551 | 8 | 3 | 7 | 4.2 | c1ccc(CN(Cc2ccc3cc(CN4CCCNCCNCCCNCC4)ccc3c2)Cc2ccccn2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| 25147749 | 8875 | 18 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 2899 | 8875 | 18 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 25147749 | 8875 | 18 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 2899 | 8875 | 18 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL192183 | 215864 | 1 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2C[C@@H](N=C(N)N)CN2C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||||
| 51346852 | 65211 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 325 | 7 | 2 | 5 | 2.7 | NCCCCN(Cc1ncccc1N)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682996 | 65211 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 325 | 7 | 2 | 5 | 2.7 | NCCCCN(Cc1ncccc1N)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2011.01.021 | ||
| 4410 | 9911 | 106 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | nan | ||
| 65015 | 9911 | 106 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | nan | ||
| 844 | 9911 | 106 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | nan | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | nan | ||
| DB06809 | 9911 | 106 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | nan | ||
| 49857288 | 70578 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 308 | 6 | 2 | 4 | 3.8 | Fc1ccccc1NCc1ccc(CNc2ncccn2)cc1 | nan | ||
| CHEMBL1802284 | 70578 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 308 | 6 | 2 | 4 | 3.8 | Fc1ccccc1NCc1ccc(CNc2ncccn2)cc1 | nan | ||
| 24804044 | 151815 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 292 | 6 | 1 | 5 | 3.1 | c1ccc(OCc2ccc(CNc3ncccn3)cc2)nc1 | nan | ||
| CHEMBL3911200 | 151815 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 292 | 6 | 1 | 5 | 3.1 | c1ccc(OCc2ccc(CNc3ncccn3)cc2)nc1 | nan | ||
| 89957222 | 154610 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 332 | 7 | 3 | 3 | 4.6 | O=C(O)c1cccc(NCc2ccc(CNc3ccccc3)cc2)c1 | nan | ||
| CHEMBL3932956 | 154610 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 332 | 7 | 3 | 3 | 4.6 | O=C(O)c1cccc(NCc2ccc(CNc3ccccc3)cc2)c1 | nan | ||
| 58757244 | 160198 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 366 | 6 | 2 | 8 | 1.8 | Fc1nc(F)nc(NCc2ccc(CNc3nc(F)nc(F)n3)cc2)n1 | nan | ||
| CHEMBL3979002 | 160198 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 366 | 6 | 2 | 8 | 1.8 | Fc1nc(F)nc(NCc2ccc(CNc3nc(F)nc(F)n3)cc2)n1 | nan | ||
| 58757234 | 161096 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 229 | 5 | 1 | 4 | 2.2 | COCc1ccc(CNc2ncccn2)cc1 | nan | ||
| CHEMBL3986703 | 161096 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 229 | 5 | 1 | 4 | 2.2 | COCc1ccc(CNc2ncccn2)cc1 | nan | ||
| 70694125 | 81332 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 740 | 12 | 11 | 7 | 1.4 | C/C1=C(/C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm2016914 | ||
| CHEMBL2029611 | 81332 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 740 | 12 | 11 | 7 | 1.4 | C/C1=C(/C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm2016914 | ||
| 259647 | 150168 | 18 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 290 | 6 | 0 | 2 | 4.8 | c1ccc(OCc2ccc(COc3ccccc3)cc2)cc1 | nan | ||
| CHEMBL3897880 | 150168 | 18 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 290 | 6 | 0 | 2 | 4.8 | c1ccc(OCc2ccc(COc3ccccc3)cc2)cc1 | nan | ||
| 611565 | 158667 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 322 | 6 | 0 | 2 | 6.3 | c1ccc(SCc2ccc(CSc3ccccc3)cc2)cc1 | nan | ||
| CHEMBL3965823 | 158667 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 322 | 6 | 0 | 2 | 6.3 | c1ccc(SCc2ccc(CSc3ccccc3)cc2)cc1 | nan | ||
| 58757247 | 159645 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 243 | 5 | 2 | 3 | 2.8 | COc1cccc(NCc2ccc(CO)cc2)c1 | nan | ||
| CHEMBL3974314 | 159645 | 1 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 243 | 5 | 2 | 3 | 2.8 | COc1cccc(NCc2ccc(CO)cc2)c1 | nan | ||
| 155523400 | 177529 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1cccc(CNCC2CCN(Cc3ccccc3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4452433 | 177529 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1cccc(CNCC2CCN(Cc3ccccc3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| 56649212 | 77367 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 744 | 12 | 8 | 8 | 0.1 | CC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949675 | 77367 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 744 | 12 | 8 | 8 | 0.1 | CC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 155545540 | 180237 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1ccc(CNCC2CCN(Cc3ccccc3Cl)CC2)cc1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4529593 | 180237 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1ccc(CNCC2CCN(Cc3ccccc3Cl)CC2)cc1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155558835 | 181556 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 318 | 6 | 2 | 3 | 3.1 | Clc1ccccc1CN1CCC(CNCc2c[nH]cn2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4561387 | 181556 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 318 | 6 | 2 | 3 | 3.1 | Clc1ccccc1CN1CCC(CNCc2c[nH]cn2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 5278946 | 175397 | 1 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 793 | 15 | 11 | 10 | 0.2 | N=C(N)NCCCN[C@H]1CSSC[C@H](C(=O)NCCc2ccc(O)cc2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||
| CHEMBL436083 | 175397 | 1 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 793 | 15 | 11 | 10 | 0.2 | N=C(N)NCCCN[C@H]1CSSC[C@H](C(=O)NCCc2ccc(O)cc2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||
| CHEMBL408062 | 219476 | 1 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | None | None | None | N=C(N)NCCCN[C@H]1CSSC[C@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||||
| 155527692 | 178042 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1cccc(CNCC2CCN(Cc3ccc(Cl)cc3)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4460308 | 178042 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1cccc(CNCC2CCN(Cc3ccc(Cl)cc3)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| 16459886 | 178268 | 23 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 294 | 6 | 1 | 2 | 3.7 | c1ccc(CNCC2CCN(Cc3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4463684 | 178268 | 23 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 294 | 6 | 1 | 2 | 3.7 | c1ccc(CNCC2CCN(Cc3ccccc3)CC2)cc1 | 10.1016/j.ejmech.2018.10.060 | ||
| 2236109 | 178637 | 31 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 238 | 3 | 1 | 2 | 2.5 | NCC1CCN(Cc2ccccc2Cl)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4469048 | 178637 | 31 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 238 | 3 | 1 | 2 | 2.5 | NCC1CCN(Cc2ccccc2Cl)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 44563689 | 196605 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 388 | 5 | 1 | 5 | 4.0 | c1ccc(CN/C(=N/C2CCCCC2)SCC2CSC3=NCCN32)cc1 | 10.1021/jm801065q | ||
| CHEMBL516480 | 196605 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 388 | 5 | 1 | 5 | 4.0 | c1ccc(CN/C(=N/C2CCCCC2)SCC2CSC3=NCCN32)cc1 | 10.1021/jm801065q | ||
| 137660298 | 166211 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 887 | 14 | 10 | 8 | 1.9 | CN1C(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=O)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/acs.jmedchem.8b00336 | ||
| CHEMBL4101089 | 166211 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 887 | 14 | 10 | 8 | 1.9 | CN1C(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=O)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H]1Cc1c[nH]c2ccccc12 | 10.1021/acs.jmedchem.8b00336 | ||
| 44400315 | 75106 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 663 | 11 | 10 | 7 | -1.5 | N=C(N)NCCC(=O)N[C@H]1C/C=C\CC[C@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||
| CHEMBL191651 | 75106 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 663 | 11 | 10 | 7 | -1.5 | N=C(N)NCCC(=O)N[C@H]1C/C=C\CC[C@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||
| 44400178 | 75428 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 677 | 11 | 10 | 7 | -1.1 | N=C(N)NCCC(=O)N[C@H]1CC/C=C\CC[C@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||
| CHEMBL191949 | 75428 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 677 | 11 | 10 | 7 | -1.1 | N=C(N)NCCC(=O)N[C@H]1CC/C=C\CC[C@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||
| 44400179 | 75436 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 769 | 14 | 11 | 8 | -0.3 | N=C(N)NCCC(=O)N[C@H]1C/C=C\C[C@H](C(=O)NCCc2ccc(O)cc2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||
| CHEMBL191998 | 75436 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 769 | 14 | 11 | 8 | -0.3 | N=C(N)NCCC(=O)N[C@H]1C/C=C\C[C@H](C(=O)NCCc2ccc(O)cc2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||
| 44400314 | 131280 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 649 | 11 | 11 | 7 | -1.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](NC(=O)CCNC(=N)N)C/C=C\C[C@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||
| CHEMBL364014 | 131280 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 649 | 11 | 11 | 7 | -1.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](NC(=O)CCNC(=N)N)C/C=C\C[C@H](C(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||
| CHEMBL440638 | 175967 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 1992 | 47 | 30 | 26 | -6.5 | C[C@H]1/C=C\[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)C(CCCNC(N)=O)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1016/s0960-894x(02)00041-0 | ||
| 138501641 | 186689 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 436 | 5 | 0 | 7 | 3.0 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCC(N3CCOCC3)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4746043 | 186689 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 436 | 5 | 0 | 7 | 3.0 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCC(N3CCOCC3)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL5281510 | 200892 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 2845 | 99 | 46 | 38 | -12.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N(CCCCCC(=O)O)[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114797 | ||
| CHEMBL3924080 | 219235 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 145965128 | 171219 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 340 | 7 | 0 | 6 | 2.2 | CN(C)CCN(C)N(Cc1ccncn1)C1CCCc2cccnc21 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4213783 | 171219 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 340 | 7 | 0 | 6 | 2.2 | CN(C)CCN(C)N(Cc1ccncn1)C1CCCc2cccnc21 | 10.1016/j.ejmech.2018.02.042 | ||
| 138501453 | 190007 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 395 | 6 | 1 | 7 | 2.6 | CCNc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4796167 | 190007 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 395 | 6 | 1 | 7 | 2.6 | CCNc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 145974150 | 171341 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 378 | 6 | 0 | 6 | 2.7 | c1cnc2c(c1)CCCC2N(Cc1ccncn1)N1CCN(CC2CC2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4215245 | 171341 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 378 | 6 | 0 | 6 | 2.7 | c1cnc2c(c1)CCCC2N(Cc1ccncn1)N1CCN(CC2CC2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 4410 | 9911 | 106 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm801065q | ||
| 65015 | 9911 | 106 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm801065q | ||
| 844 | 9911 | 106 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm801065q | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm801065q | ||
| DB06809 | 9911 | 106 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm801065q | ||
| 134134119 | 149949 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 3125 | 83 | 50 | 44 | -10.8 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3896065 | 149949 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 3125 | 83 | 50 | 44 | -10.8 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL506505 | 220989 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](c2ccc3ccccc3c2)NC1=O | 10.1021/jm801065q | ||||
| 145958234 | 168960 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 407 | 4 | 2 | 5 | 3.9 | O=C(NNc1cnccn1)c1ccccc1-n1ccc2cc(Br)ccc21 | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4162534 | 168960 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 407 | 4 | 2 | 5 | 3.9 | O=C(NNc1cnccn1)c1ccccc1-n1ccc2cc(Br)ccc21 | 10.1016/j.ejmech.2017.08.027 | ||
| 66558750 | 82235 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=N | 10.1021/ml200047e | ||
| CHEMBL2042120 | 82235 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=N | 10.1021/ml200047e | ||
| 25147749 | 8875 | 18 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/jm801065q | ||
| 2899 | 8875 | 18 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/jm801065q | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/jm801065q | ||
| 72535488 | 156421 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 539 | 9 | 1 | 7 | 4.0 | CN1CCN(C(=O)Cn2c3ccccc3c3ccnc(CN(CCCCN)C4CCCc5cccnc54)c32)CC1 | nan | ||
| CHEMBL3947305 | 156421 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 539 | 9 | 1 | 7 | 4.0 | CN1CCN(C(=O)Cn2c3ccccc3c3ccnc(CN(CCCCN)C4CCCc5cccnc54)c32)CC1 | nan | ||
| 11678324 | 171549 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 543 | 9 | 2 | 6 | 4.8 | Cc1ccsc1CN1CCC2(CC1)CCN(Cc1ccc(C(=O)N(Cc3ncc[nH]3)Cc3ncc[nH]3)cc1)C2 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL4218006 | 171549 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 543 | 9 | 2 | 6 | 4.8 | Cc1ccsc1CN1CCC2(CC1)CCN(Cc1ccc(C(=O)N(Cc3ncc[nH]3)Cc3ncc[nH]3)cc1)C2 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL373636 | 218965 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | C[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm0607350 | ||||
| CHEMBL375990 | 219016 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | C[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm0607350 | ||||
| 155560529 | 181856 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 2536 | 93 | 31 | 37 | -7.8 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)NCCOCCOCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCOCCOCCNC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4568383 | 181856 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 2536 | 93 | 31 | 37 | -7.8 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)NCCOCCOCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCOCCOCCNC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| 71716525 | 94983 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 649 | 12 | 8 | 3 | 8.2 | N=C(NCCCCN(CCCNC(=N)Nc1cccc2ccccc12)C(=N)Nc1cccc2ccccc12)Nc1cccc2ccccc12 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2347628 | 94983 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 649 | 12 | 8 | 3 | 8.2 | N=C(NCCCCN(CCCNC(=N)Nc1cccc2ccccc12)C(=N)Nc1cccc2ccccc12)Nc1cccc2ccccc12 | 10.1016/j.bmcl.2013.01.107 | ||
| 71718364 | 94986 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 538 | 15 | 8 | 4 | 5.3 | N=C(NCCCNCCCCNCCCNC(=N)Nc1ccc2ccccc2c1)Nc1ccc2ccccc2c1 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2347631 | 94986 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 538 | 15 | 8 | 4 | 5.3 | N=C(NCCCNCCCCNCCCNC(=N)Nc1ccc2ccccc2c1)Nc1ccc2ccccc2c1 | 10.1016/j.bmcl.2013.01.107 | ||
| 155544593 | 180115 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 1165 | 35 | 18 | 16 | -5.1 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4526799 | 180115 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 1165 | 35 | 18 | 16 | -5.1 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| 134139386 | 153357 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 3137 | 86 | 45 | 43 | -6.4 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3923006 | 153357 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 3137 | 86 | 45 | 43 | -6.4 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| 57345320 | 10604 | 9 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1016/j.bmcl.2015.04.036 | ||
| 9882 | 10604 | 9 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3091687 | 10604 | 9 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1016/j.bmcl.2015.04.036 | ||
| 162675312 | 190185 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 404 | 5 | 2 | 5 | 5.2 | CCOC(=O)c1c(NC(=S)Nc2ccc(OC)cc2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL4798282 | 190185 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 404 | 5 | 2 | 5 | 5.2 | CCOC(=O)c1c(NC(=S)Nc2ccc(OC)cc2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| 162642884 | 188498 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 390 | 4 | 3 | 5 | 4.9 | CCOC(=O)c1c(NC(=S)Nc2ccc(O)cc2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL4777007 | 188498 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 390 | 4 | 3 | 5 | 4.9 | CCOC(=O)c1c(NC(=S)Nc2ccc(O)cc2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| 162672731 | 189797 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 392 | 4 | 2 | 4 | 5.3 | CCOC(=O)c1c(NC(=S)Nc2ccc(F)cc2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL4793810 | 189797 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 392 | 4 | 2 | 4 | 5.3 | CCOC(=O)c1c(NC(=S)Nc2ccc(F)cc2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL5283078 | 200965 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 414 | 14 | 4 | 4 | 4.5 | c1cc(CNCCCNC2CCCCC2)ccc1CNCCCNC1CCCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| CHEMBL5275975 | 200659 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 457 | 15 | 4 | 5 | 4.6 | CN(C)c1cc(CNCCCNC2CCCCC2)cc(CNCCCNC2CCCCC2)c1 | 10.1016/j.ejmech.2020.112410 | ||
| 162667135 | 189276 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 402 | 3 | 2 | 4 | 6.0 | CC1CCCc2sc(NC(=S)Nc3ccccc3)c(C(=O)OC(C)(C)C)c21 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL4786878 | 189276 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 402 | 3 | 2 | 4 | 6.0 | CC1CCCc2sc(NC(=S)Nc3ccccc3)c(C(=O)OC(C)(C)C)c21 | 10.1016/j.ejmech.2020.112387 | ||
| 138501803 | 186392 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 384 | 4 | 0 | 6 | 2.6 | Cc1nc(CN(C)C2CCCc3cccnc32)c(F)c(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4742656 | 186392 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 384 | 4 | 0 | 6 | 2.6 | Cc1nc(CN(C)C2CCCc3cccnc32)c(F)c(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 138491872 | 188656 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.4 | Cc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4778921 | 188656 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.4 | Cc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 146970182 | 196865 | 2 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 522 | 17 | 7 | 6 | 2.5 | N=C(N)NCCC[C@H](NCc1ccccn1)C(=O)NCc1ccc(CNCCCNC2CCCCC2)cc1 | 10.1016/j.ejmech.2022.114150 | ||
| CHEMBL5172755 | 196865 | 2 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 522 | 17 | 7 | 6 | 2.5 | N=C(N)NCCC[C@H](NCc1ccccn1)C(=O)NCc1ccc(CNCCCNC2CCCCC2)cc1 | 10.1016/j.ejmech.2022.114150 | ||
| 56647928 | 77381 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 1485 | 27 | 18 | 16 | -0.4 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 91930551 | 77381 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 1485 | 27 | 18 | 16 | -0.4 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949736 | 77381 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 1485 | 27 | 18 | 16 | -0.4 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 72535506 | 149521 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 540 | 9 | 2 | 7 | 4.2 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCC(O)CC3)c12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3892446 | 149521 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 540 | 9 | 2 | 7 | 4.2 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCC(O)CC3)c12)C1CCCc2cccnc21 | nan | ||
| 72535470 | 153018 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 539 | 10 | 3 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)NC3CCNCC3)c12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3920438 | 153018 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 539 | 10 | 3 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)NC3CCNCC3)c12)C1CCCc2cccnc21 | nan | ||
| 72535480 | 154125 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 498 | 9 | 2 | 7 | 3.8 | OCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)C3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3929341 | 154125 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 498 | 9 | 2 | 7 | 3.8 | OCCn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)C3CCCc4cccnc43)c21 | nan | ||
| 76324529 | 110607 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 455 | 10 | 2 | 5 | 4.4 | c1ccc(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)nc1 | 10.1021/ml400183q | ||
| CHEMBL3091683 | 110607 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 455 | 10 | 2 | 5 | 4.4 | c1ccc(CNCCCCN(C[C@H]2Cc3ccccc3CN2)[C@H]2CCCc3cccnc32)nc1 | 10.1021/ml400183q | ||
| 57345320 | 10604 | 9 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| 9882 | 10604 | 9 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| CHEMBL3091687 | 10604 | 9 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| 46206137 | 15142 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 488 | 9 | 2 | 5 | 5.7 | c1ccc(CNCc2ccc(CN(Cc3nc4ccccc4[nH]3)[C@H]3CCCc4cccnc43)cc2)nc1 | 10.1021/jm100073m | ||
| CHEMBL1093137 | 15142 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 488 | 9 | 2 | 5 | 5.7 | c1ccc(CNCc2ccc(CN(Cc3nc4ccccc4[nH]3)[C@H]3CCCc4cccnc43)cc2)nc1 | 10.1021/jm100073m | ||
| 24894090 | 179519 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 572 | 13 | 9 | 5 | 2.8 | CC(C)C[C@H](NC(=N)N)C(=O)Nc1ccc2c(c1)cc(C(=O)NCCc1c[nH]c3ccccc13)n2CCCNC(=N)N | 10.1016/j.bmcl.2008.05.092 | ||
| CHEMBL450815 | 179519 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 572 | 13 | 9 | 5 | 2.8 | CC(C)C[C@H](NC(=N)N)C(=O)Nc1ccc2c(c1)cc(C(=O)NCCc1c[nH]c3ccccc13)n2CCCNC(=N)N | 10.1016/j.bmcl.2008.05.092 | ||
| 56750906 | 129775 | 6 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.8 | c1ccc(Cc2cn[nH]c2C2CCN(Cc3ccncc3)CC2)cc1 | 10.1021/acsmedchemlett.5b00036 | ||
| CHEMBL3608763 | 129775 | 6 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 332 | 5 | 1 | 3 | 3.8 | c1ccc(Cc2cn[nH]c2C2CCN(Cc3ccncc3)CC2)cc1 | 10.1021/acsmedchemlett.5b00036 | ||
| 5275843 | 220457 | 31 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/acs.jmedchem.5b00216 | ||||
| CHEMBL2180076 | 220457 | 31 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/acs.jmedchem.5b00216 | ||||
| CHEMBL436283 | 220457 | 31 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/acs.jmedchem.5b00216 | ||||
| 162664334 | 188895 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 392 | 4 | 2 | 4 | 5.3 | CCOC(=O)c1c(NC(=S)Nc2ccccc2F)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL4782034 | 188895 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 392 | 4 | 2 | 4 | 5.3 | CCOC(=O)c1c(NC(=S)Nc2ccccc2F)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL5277386 | 200713 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 415 | 14 | 4 | 5 | 3.9 | c1cc(CNCCCNC2CCCCC2)nc(CNCCCNC2CCCCC2)c1 | 10.1016/j.ejmech.2020.112410 | ||
| CHEMBL3916038 | 219229 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.6b00695 | ||||
| 137651290 | 164243 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 985 | 18 | 15 | 13 | -1.6 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4079246 | 164243 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 985 | 18 | 15 | 13 | -1.6 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| 155529939 | 178253 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 358 | 7 | 1 | 3 | 4.4 | COc1ccc(CNCC2CCN(Cc3ccccc3Cl)CC2)cc1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4463569 | 178253 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 358 | 7 | 1 | 3 | 4.4 | COc1ccc(CNCC2CCN(Cc3ccccc3Cl)CC2)cc1 | 10.1016/j.ejmech.2018.10.060 | ||
| 5275843 | 220457 | 31 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/ml200047e | ||||
| CHEMBL2180076 | 220457 | 31 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/ml200047e | ||||
| CHEMBL436283 | 220457 | 31 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/ml200047e | ||||
| CHEMBL3983197 | 219301 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 162669363 | 189544 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 458 | 5 | 2 | 5 | 6.1 | CCOC(=O)c1c(NC(=S)Nc2ccc(OC(F)(F)F)cc2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL4790233 | 189544 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 458 | 5 | 2 | 5 | 6.1 | CCOC(=O)c1c(NC(=S)Nc2ccc(OC(F)(F)F)cc2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL219096 | 216185 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CNC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm0607350 | ||||
| 138501447 | 187803 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 432 | 5 | 0 | 8 | 2.5 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)nc(-c3cnn(C)c3)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4759222 | 187803 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 432 | 5 | 0 | 8 | 2.5 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)nc(-c3cnn(C)c3)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| 11256587 | 9240 | 59 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/jm100073m | ||
| 8580 | 9240 | 59 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/jm100073m | ||
| CHEMBL518924 | 9240 | 59 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/jm100073m | ||
| DB05501 | 9240 | 59 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/jm100073m | ||
| 465968 | 95975 | 9 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 551 | 13 | 6 | 5 | 3.8 | C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)c1ccc(CNCc2ccccn2)cc1)c1cccc2ccccc12 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL2367715 | 95975 | 9 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 551 | 13 | 6 | 5 | 3.8 | C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)c1ccc(CNCc2ccccn2)cc1)c1cccc2ccccc12 | 10.1016/j.ejmech.2018.02.043 | ||
| 138501802 | 188996 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 408 | 5 | 0 | 7 | 2.2 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C3COC3)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4783171 | 188996 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 408 | 5 | 0 | 7 | 2.2 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C3COC3)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL373440 | 218955 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | C[C@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CNC1=O | 10.1021/jm0607350 | ||||
| 145972313 | 171353 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)[C@@H]3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4215380 | 171353 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)[C@@H]3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL3980379 | 219292 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.6b00695 | ||||
| 57345319 | 110603 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN(C[C@@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091677 | 110603 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN(C[C@@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 134143183 | 152005 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 3080 | 81 | 50 | 42 | -10.0 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC(CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3912645 | 152005 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 3080 | 81 | 50 | 42 | -10.0 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC(CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3963508 | 219273 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)C1(NC(=O)[C@@H](N)CCCCN)Cc2ccccc2C1)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL5288598 | 201212 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 320 | 5 | 2 | 6 | 3.0 | Nc1nc2ccccc2n1CCCCn1c(N)nc2ccccc21 | 10.1021/acs.jmedchem.6b01309 | ||
| 138501639 | 187544 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 380 | 4 | 0 | 6 | 2.8 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C)C[C@@H]2C)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4756203 | 187544 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 380 | 4 | 0 | 6 | 2.8 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C)C[C@@H]2C)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 138501640 | 188722 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 380 | 4 | 0 | 6 | 2.8 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C)[C@@H](C)C2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4779872 | 188722 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 380 | 4 | 0 | 6 | 2.8 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C)[C@@H](C)C2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 155551439 | 180767 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 2876 | 99 | 49 | 42 | -16.5 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)NCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)[C@@H](C)O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4542285 | 180767 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 2876 | 99 | 49 | 42 | -16.5 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)NCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)[C@@H](C)O | 10.1016/j.ejmech.2019.03.056 | ||
| 56648499 | 77391 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 1613 | 32 | 20 | 18 | -1.8 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)CCCC(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 91930559 | 77391 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 1613 | 32 | 20 | 18 | -1.8 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)CCCC(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949886 | 77391 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 1613 | 32 | 20 | 18 | -1.8 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)CCCC(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 155566596 | 182579 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 2360 | 81 | 31 | 33 | -7.9 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4584349 | 182579 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 2360 | 81 | 31 | 33 | -7.9 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL506505 | 220989 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](c2ccc3ccccc3c2)NC1=O | 10.1021/jm801065q | ||||
| 162671201 | 189658 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 442 | 4 | 2 | 4 | 6.2 | CCOC(=O)c1c(NC(=S)Nc2ccc(C(F)(F)F)cc2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL4791845 | 189658 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 442 | 4 | 2 | 4 | 6.2 | CCOC(=O)c1c(NC(=S)Nc2ccc(C(F)(F)F)cc2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| 155534395 | 178694 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 3333 | 111 | 47 | 45 | -10.3 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CCCCCNC(=O)[C@H]1CCCN1C(=O)[C@@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CS)NC(=O)[C@@H](CS)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4469971 | 178694 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 3333 | 111 | 47 | 45 | -10.3 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CCCCCNC(=O)[C@H]1CCCN1C(=O)[C@@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CS)NC(=O)[C@@H](CS)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| 155534395 | 178694 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 3333 | 111 | 47 | 45 | -10.3 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CCCCCNC(=O)[C@H]1CCCN1C(=O)[C@@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CS)NC(=O)[C@@H](CS)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4469971 | 178694 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 3333 | 111 | 47 | 45 | -10.3 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CCCCCNC(=O)[C@H]1CCCN1C(=O)[C@@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CS)NC(=O)[C@@H](CS)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| 137637211 | 162611 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 677 | 21 | 7 | 12 | 2.1 | CCc1cc(NC2CCN(C(=O)CCNCCP(=O)(O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4059987 | 162611 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 677 | 21 | 7 | 12 | 2.1 | CCc1cc(NC2CCN(C(=O)CCNCCP(=O)(O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL5276826 | 200693 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 459 | 15 | 4 | 6 | 4.4 | O=[N+]([O-])c1cc(CNCCCNC2CCCCC2)cc(CNCCCNC2CCCCC2)c1 | 10.1016/j.ejmech.2020.112410 | ||
| 57345320 | 10604 | 9 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| 9882 | 10604 | 9 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| CHEMBL3091687 | 10604 | 9 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| 68730442 | 150162 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 581 | 9 | 1 | 8 | 3.6 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)C3CCCc4cccnc43)c21)N1CCOCC1 | nan | ||
| CHEMBL3897853 | 150162 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 581 | 9 | 1 | 8 | 3.6 | O=C(Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)C3CCCc4cccnc43)c21)N1CCOCC1 | nan | ||
| 67501386 | 171163 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 9 | 2 | 5 | 3.9 | CC(C)CN1CCC2(CCN(Cc3ccc(C(=O)N(Cc4ncc[nH]4)Cc4ncc[nH]4)cc3)CC2)C1 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL4213081 | 171163 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 9 | 2 | 5 | 3.9 | CC(C)CN1CCC2(CCN(Cc3ccc(C(=O)N(Cc4ncc[nH]4)Cc4ncc[nH]4)cc3)CC2)C1 | 10.1016/j.ejmech.2018.02.043 | ||
| 145977928 | 170705 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 352 | 5 | 0 | 6 | 2.3 | CN(C)C1CCN(N(Cc2ccncn2)C2CCCc3cccnc32)C1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4207399 | 170705 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 352 | 5 | 0 | 6 | 2.3 | CN(C)C1CCN(N(Cc2ccncn2)C2CCCc3cccnc32)C1 | 10.1016/j.ejmech.2018.02.042 | ||
| 66902958 | 170806 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 351 | 5 | 1 | 5 | 3.5 | c1ccc(CN2CCC(Nc3nccc(N4CCCCCC4)n3)C2)cc1 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL4208687 | 170806 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 351 | 5 | 1 | 5 | 3.5 | c1ccc(CN2CCC(Nc3nccc(N4CCCCCC4)n3)C2)cc1 | 10.1016/j.ejmech.2018.02.043 | ||
| 138501622 | 188003 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 410 | 6 | 0 | 7 | 2.9 | CC(C)Oc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4761394 | 188003 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 410 | 6 | 0 | 7 | 2.9 | CC(C)Oc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL3932032 | 219243 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 118722241 | 122917 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 477 | 13 | 6 | 3 | 3.1 | N=C(N)NCCCC[C@H]1C=C[C@H](CCc2ccc3ccccc3c2)N(CCCCNC(=N)N)C1=O | 10.1016/j.bmc.2014.07.004 | ||
| CHEMBL3357471 | 122917 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 477 | 13 | 6 | 3 | 3.1 | N=C(N)NCCCC[C@H]1C=C[C@H](CCc2ccc3ccccc3c2)N(CCCCNC(=N)N)C1=O | 10.1016/j.bmc.2014.07.004 | ||
| 57345320 | 10604 | 9 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| 9882 | 10604 | 9 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL3091687 | 10604 | 9 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2009.01.014 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2009.01.014 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2009.01.014 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2009.01.014 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2009.01.014 | ||
| 137637457 | 162624 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 969 | 18 | 14 | 12 | -1.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C(=O)O)CSSC1(C)C | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4060078 | 162624 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 969 | 18 | 14 | 12 | -1.3 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C(=O)O)CSSC1(C)C | 10.1021/acs.jmedchem.7b01062 | ||
| 25178569 | 183772 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 434 | 4 | 1 | 5 | 5.9 | CC(C)(C)C1CCC(N/C(=N/C2CCCCC2)SCC2=CSC3=NCCN23)CC1 | 10.1021/jm801065q | ||
| CHEMBL462588 | 183772 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 434 | 4 | 1 | 5 | 5.9 | CC(C)(C)C1CCC(N/C(=N/C2CCCCC2)SCC2=CSC3=NCCN23)CC1 | 10.1021/jm801065q | ||
| 138501425 | 189003 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.5 | Cc1nc(CN2CCC(C)C2c2ccccn2)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4783241 | 189003 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.5 | Cc1nc(CN2CCC(C)C2c2ccccn2)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL5283007 | 200959 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 414 | 14 | 4 | 4 | 4.5 | c1cc(CNCCCNC2CCCCC2)cc(CNCCCNC2CCCCC2)c1 | 10.1016/j.ejmech.2020.112410 | ||
| 155513627 | 176560 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 2223 | 82 | 28 | 33 | -7.6 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4439040 | 176560 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 2223 | 82 | 28 | 33 | -7.6 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL375993 | 219017 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CNC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm0607350 | ||||
| 118965421 | 163616 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 598 | 18 | 5 | 11 | 2.9 | Cc1cc(NC2CCN(C(=O)CCCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4071355 | 163616 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 598 | 18 | 5 | 11 | 2.9 | Cc1cc(NC2CCN(C(=O)CCCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 155523400 | 177529 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1cccc(CNCC2CCN(Cc3ccccc3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4452433 | 177529 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1cccc(CNCC2CCN(Cc3ccccc3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| 46888759 | 15375 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 417 | 7 | 1 | 5 | 3.3 | CN(C)CC(=O)NCc1c(CN(C)[C@H]2CCCc3cccnc32)ncc2ccccc12 | 10.1016/j.bmcl.2010.03.118 | ||
| CHEMBL1094864 | 15375 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 417 | 7 | 1 | 5 | 3.3 | CN(C)CC(=O)NCc1c(CN(C)[C@H]2CCCc3cccnc32)ncc2ccccc12 | 10.1016/j.bmcl.2010.03.118 | ||
| 155551439 | 180767 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 2876 | 99 | 49 | 42 | -16.5 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)NCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)[C@@H](C)O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4542285 | 180767 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 2876 | 99 | 49 | 42 | -16.5 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)NCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)[C@@H](C)O | 10.1016/j.ejmech.2019.03.056 | ||
| 53344613 | 82236 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=N | 10.1021/ml200047e | ||
| CHEMBL2042232 | 82236 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=N | 10.1021/ml200047e | ||
| CHEMBL2371850 | 216917 | 1 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | NCC[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||||
| CHEMBL2012652 | 215906 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)C1)C(=O)O | 10.1021/ml200084n | ||||
| 53322803 | 65212 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 323 | 8 | 2 | 4 | 3.3 | C[C@@H](c1ccccn1)N(CCCCN)Cc1nc2ccccc2[nH]1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682997 | 65212 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 323 | 8 | 2 | 4 | 3.3 | C[C@@H](c1ccccn1)N(CCCCN)Cc1nc2ccccc2[nH]1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL191942 | 215863 | 1 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||||
| CHEMBL219075 | 216184 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)CN(C)C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm0607350 | ||||
| CHEMBL5283015 | 200960 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 12 | 4 | 4 | 3.8 | O=C(NCCCNC1CCCCC1)c1ccc(C(=O)NCCCNC2CCCCC2)cc1 | 10.1016/j.ejmech.2020.112410 | ||
| 138501799 | 186326 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 380 | 5 | 0 | 6 | 2.8 | CCN(Cc1cc(N2CCN(C)CC2)nc(C)n1)C1CCCc2cccnc21 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4741628 | 186326 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 380 | 5 | 0 | 6 | 2.8 | CCN(Cc1cc(N2CCN(C)CC2)nc(C)n1)C1CCCc2cccnc21 | 10.1016/j.ejmech.2019.111914 | ||
| 56648503 | 77395 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 2127 | 47 | 25 | 27 | -4.5 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)CC(CC(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C)NC(=O)CCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/jm2009716 | ||
| 91930563 | 77395 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 2127 | 47 | 25 | 27 | -4.5 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)CC(CC(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C)NC(=O)CCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/jm2009716 | ||
| CHEMBL1949890 | 77395 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 2127 | 47 | 25 | 27 | -4.5 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)CC(CC(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C)NC(=O)CCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/jm2009716 | ||
| 145966697 | 171052 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.3 | CN1CCCN(N(Cc2ccncn2)C2CCCc3cccnc32)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4211758 | 171052 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.3 | CN1CCCN(N(Cc2ccncn2)C2CCCc3cccnc32)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL2012529 | 215901 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCC[C@@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)C1)C(=O)O | 10.1021/ml200084n | ||||
| CHEMBL364011 | 218699 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | NC(=O)CC[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||||
| CHEMBL387120 | 219185 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm0607350 | ||||
| 44561526 | 195775 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 606 | 13 | 9 | 5 | 3.0 | N=C(N)NCCCn1c(C(=O)NCCc2c[nH]c3ccccc23)cc2cc(NC(=O)[C@H](Cc3ccccc3)NC(=N)N)ccc21 | 10.1016/j.bmcl.2008.05.092 | ||
| CHEMBL508684 | 195775 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 606 | 13 | 9 | 5 | 3.0 | N=C(N)NCCCn1c(C(=O)NCCc2c[nH]c3ccccc23)cc2cc(NC(=O)[C@H](Cc3ccccc3)NC(=N)N)ccc21 | 10.1016/j.bmcl.2008.05.092 | ||
| 137655630 | 165492 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 898 | 14 | 9 | 8 | 2.6 | CN1C(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=O)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H]1Cc1cccc2ccccc12 | 10.1021/acs.jmedchem.8b00336 | ||
| CHEMBL4093348 | 165492 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 898 | 14 | 9 | 8 | 2.6 | CN1C(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=O)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H]1Cc1cccc2ccccc12 | 10.1021/acs.jmedchem.8b00336 | ||
| CHEMBL3933112 | 219246 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 162652106 | 187081 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 1090 | 24 | 7 | 15 | 5.0 | CC1(C)CN2C(CS/C(=N\[C@H]3CC[C@H](CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@@H]4CC[C@@]5(O)[C@H]6Cc7ccc(O)c8c7[C@@]5(CCN6CC5CC5)[C@H]4O8)CC3)NC3CCCCC3)=CSC2=N1 | 10.1039/c9md00433e | ||
| CHEMBL4750948 | 187081 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 1090 | 24 | 7 | 15 | 5.0 | CC1(C)CN2C(CS/C(=N\[C@H]3CC[C@H](CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@@H]4CC[C@@]5(O)[C@H]6Cc7ccc(O)c8c7[C@@]5(CCN6CC5CC5)[C@H]4O8)CC3)NC3CCCCC3)=CSC2=N1 | 10.1039/c9md00433e | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 138501633 | 188083 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 392 | 4 | 0 | 6 | 3.0 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN3CCC[C@H]3C2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4762425 | 188083 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 392 | 4 | 0 | 6 | 3.0 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN3CCC[C@H]3C2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 155542701 | 179935 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 2855 | 101 | 48 | 40 | -13.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)CCCCCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CS)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4521504 | 179935 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 2855 | 101 | 48 | 40 | -13.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)CCCCCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CS)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| 145975537 | 170359 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 509 | 9 | 1 | 8 | 3.8 | CN1CCN(c2cc(CN(CCCCNC(=O)OC(C)(C)C)C3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4203303 | 170359 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 509 | 9 | 1 | 8 | 3.8 | CN1CCN(c2cc(CN(CCCCNC(=O)OC(C)(C)C)C3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 145972040 | 171279 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 409 | 8 | 1 | 7 | 2.2 | CN1CCN(c2cc(CN(CCCCN)C3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4214538 | 171279 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 409 | 8 | 1 | 7 | 2.2 | CN1CCN(c2cc(CN(CCCCN)C3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 134132933 | 151954 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 3169 | 82 | 52 | 43 | -9.8 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)c1cc2ccccc2[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3912312 | 151954 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 3169 | 82 | 52 | 43 | -9.8 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)c1cc2ccccc2[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| 138491830 | 170676 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2ccnc(CN(C)C3CCCc4cccnc43)n2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4207126 | 170676 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2ccnc(CN(C)C3CCCc4cccnc43)n2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 71718960 | 94985 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 538 | 15 | 8 | 4 | 5.3 | N=C(NCCCNCCCCNCCCNC(=N)Nc1cccc2ccccc12)Nc1cccc2ccccc12 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2347630 | 94985 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 538 | 15 | 8 | 4 | 5.3 | N=C(NCCCNCCCCNCCCNC(=N)Nc1cccc2ccccc12)Nc1cccc2ccccc12 | 10.1016/j.bmcl.2013.01.107 | ||
| 5275846 | 85769 | 1 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 712 | 12 | 11 | 7 | 0.8 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)C/C=C/[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm049429h | ||
| CHEMBL2113070 | 85769 | 1 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 712 | 12 | 11 | 7 | 0.8 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)C/C=C/[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm049429h | ||
| 137637646 | 163002 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1014 | 19 | 14 | 14 | -1.4 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4064578 | 163002 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1014 | 19 | 14 | 14 | -1.4 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| 137654103 | 165809 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 1019 | 18 | 14 | 12 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4096721 | 165809 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 1019 | 18 | 14 | 12 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| 25178766 | 196623 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 392 | 4 | 1 | 5 | 5.0 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCCC2)N2CCCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL516630 | 196623 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 392 | 4 | 1 | 5 | 5.0 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCCC2)N2CCCN=C2S1 | 10.1021/jm801065q | ||
| 25178142 | 197364 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 430 | 4 | 1 | 5 | 5.2 | C1=C(CS/C(=N\C2CCCCC2)NC23CC4CC(CC(C4)C2)C3)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL518041 | 197364 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 430 | 4 | 1 | 5 | 5.2 | C1=C(CS/C(=N\C2CCCCC2)NC23CC4CC(CC(C4)C2)C3)N2CCN=C2S1 | 10.1021/jm801065q | ||
| 25147749 | 8875 | 18 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| 2899 | 8875 | 18 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| 56647927 | 77380 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1500 | 28 | 17 | 16 | 0.2 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 91930550 | 77380 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1500 | 28 | 17 | 16 | 0.2 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949735 | 77380 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1500 | 28 | 17 | 16 | 0.2 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL2180085 | 216214 | 1 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||||
| CHEMBL2220487 | 216214 | 1 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||||
| 132578413 | 151507 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 345 | 8 | 2 | 3 | 5.4 | CCc1ccc(NCc2cccc(CNc3ccc(CC)cc3)n2)cc1 | 10.1016/j.bmc.2016.08.018 | ||
| CHEMBL3908835 | 151507 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 345 | 8 | 2 | 3 | 5.4 | CCc1ccc(NCc2cccc(CNc3ccc(CC)cc3)n2)cc1 | 10.1016/j.bmc.2016.08.018 | ||
| CHEMBL5283078 | 200965 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 414 | 14 | 4 | 4 | 4.5 | c1cc(CNCCCNC2CCCCC2)ccc1CNCCCNC1CCCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| 50942117 | 63676 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 398 | 6 | 2 | 5 | 3.9 | NCc1ncccc1CN(Cc1nc2ccccc2[nH]1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644080 | 63676 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 398 | 6 | 2 | 5 | 3.9 | NCc1ncccc1CN(Cc1nc2ccccc2[nH]1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 71718363 | 94984 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 649 | 12 | 8 | 3 | 8.2 | N=C(NCCCCN(CCCNC(=N)Nc1ccc2ccccc2c1)C(=N)Nc1ccc2ccccc2c1)Nc1ccc2ccccc2c1 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2347629 | 94984 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 649 | 12 | 8 | 3 | 8.2 | N=C(NCCCCN(CCCNC(=N)Nc1ccc2ccccc2c1)C(=N)Nc1ccc2ccccc2c1)Nc1ccc2ccccc2c1 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2112323 | 216017 | 6 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm049429h | ||||
| 155515208 | 176723 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 3641 | 120 | 51 | 47 | -9.3 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CS)C(=O)N[C@H](CS)C(=O)N[C@H](CC(C)C)C(=O)NCC(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(C)C)C(=O)N1CCC[C@@H]1C(=O)NCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CC(=O)O)C(=O)NCC(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4441528 | 176723 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 3641 | 120 | 51 | 47 | -9.3 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CS)C(=O)N[C@H](CS)C(=O)N[C@H](CC(C)C)C(=O)NCC(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(C)C)C(=O)N1CCC[C@@H]1C(=O)NCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CC(=O)O)C(=O)NCC(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| 155515208 | 176723 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 3641 | 120 | 51 | 47 | -9.3 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CS)C(=O)N[C@H](CS)C(=O)N[C@H](CC(C)C)C(=O)NCC(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(C)C)C(=O)N1CCC[C@@H]1C(=O)NCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CC(=O)O)C(=O)NCC(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4441528 | 176723 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 3641 | 120 | 51 | 47 | -9.3 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CS)C(=O)N[C@H](CS)C(=O)N[C@H](CC(C)C)C(=O)NCC(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(C)C)C(=O)N1CCC[C@@H]1C(=O)NCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CC(=O)O)C(=O)NCC(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL5291454 | 201310 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 415 | 14 | 4 | 5 | 3.9 | c1cc(CNCCCNC2CCCCC2)ncc1CNCCCNC1CCCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 57345320 | 10604 | 9 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| 9882 | 10604 | 9 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL3091687 | 10604 | 9 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155547373 | 180387 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 362 | 6 | 1 | 2 | 5.0 | Clc1ccccc1CNCC1CCN(Cc2ccccc2Cl)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4533528 | 180387 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 362 | 6 | 1 | 2 | 5.0 | Clc1ccccc1CNCC1CCN(Cc2ccccc2Cl)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155544179 | 180118 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 329 | 6 | 1 | 3 | 3.7 | Clc1ccccc1CN1CCC(CNCc2cccnc2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4526858 | 180118 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 329 | 6 | 1 | 3 | 3.7 | Clc1ccccc1CN1CCC(CNCc2cccnc2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 56648130 | 77384 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1569 | 33 | 18 | 16 | 1.9 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCCCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 91930554 | 77384 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1569 | 33 | 18 | 16 | 1.9 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCCCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949739 | 77384 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1569 | 33 | 18 | 16 | 1.9 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCCCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949730 | 215879 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=N)N | 10.1021/jm2009716 | ||||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2012526 | 215898 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)CC1=O | 10.1021/ml200084n | ||||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| 72546065 | 110616 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 7 | 1 | 4 | 3.6 | CN1Cc2ccccc2C[C@@H]1CN(CCCCN)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091693 | 110616 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 7 | 1 | 4 | 3.6 | CN1Cc2ccccc2C[C@@H]1CN(CCCCN)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 72546066 | 110617 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 4.3 | CC(C)N1Cc2ccccc2C[C@@H]1CN(CCCCN)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091694 | 110617 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 406 | 8 | 1 | 4 | 4.3 | CC(C)N1Cc2ccccc2C[C@@H]1CN(CCCCN)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 137633531 | 163059 | 0 | None | - | 0 | Mouse | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 476 | 9 | 2 | 5 | 4.7 | CC(C)(CCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)CNC1CCOCC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4065224 | 163059 | 0 | None | - | 0 | Mouse | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 476 | 9 | 2 | 5 | 4.7 | CC(C)(CCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)CNC1CCOCC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 131801411 | 165096 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1009 | 18 | 15 | 13 | -1.4 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4089168 | 165096 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1009 | 18 | 15 | 13 | -1.4 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| 145976437 | 170723 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 351 | 4 | 0 | 5 | 2.7 | CN1CCN(c2ccnc(CN(C)C3CCCc4cccnc43)c2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4207646 | 170723 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 351 | 4 | 0 | 5 | 2.7 | CN1CCN(c2ccnc(CN(C)C3CCCc4cccnc43)c2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 10198583 | 171206 | 4 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 235 | 4 | 2 | 5 | 1.2 | NCCNc1nccc(N2CCCCCC2)n1 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL4213624 | 171206 | 4 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 235 | 4 | 2 | 5 | 1.2 | NCCNc1nccc(N2CCCCCC2)n1 | 10.1016/j.ejmech.2018.02.043 | ||
| 155518667 | 177091 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 1166 | 35 | 18 | 16 | -4.5 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4446733 | 177091 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 1166 | 35 | 18 | 16 | -4.5 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)O | 10.1016/j.bmc.2016.08.062 | ||
| 11233382 | 15144 | 4 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN(Cc1nc2ccccc2[nH]1)[C@@H]1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1093149 | 15144 | 4 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN(Cc1nc2ccccc2[nH]1)[C@@H]1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 138501644 | 187003 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 380 | 4 | 0 | 6 | 2.8 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C)C[C@H]2C)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4749835 | 187003 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 380 | 4 | 0 | 6 | 2.8 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C)C[C@H]2C)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL376219 | 219021 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CN1C(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCNC(=N)N | 10.1021/jm0607350 | ||||
| CHEMBL2012531 | 215903 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)C1)C(=O)O | 10.1021/ml200084n | ||||
| CHEMBL2012530 | 215902 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)C1)C(=O)O | 10.1021/ml200084n | ||||
| 76331766 | 110609 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 8 | 3 | 4 | 2.9 | NC(=O)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091685 | 110609 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 8 | 3 | 4 | 2.9 | NC(=O)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 145972839 | 171446 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 366 | 5 | 0 | 6 | 2.7 | CC(C)N1CCN(N(Cc2ccncn2)C2CCCc3cccnc32)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4216789 | 171446 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 366 | 5 | 0 | 6 | 2.7 | CC(C)N1CCN(N(Cc2ccncn2)C2CCCc3cccnc32)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 137632426 | 163139 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 1003 | 18 | 14 | 12 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4065967 | 163139 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 1003 | 18 | 14 | 12 | -0.7 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| 137640842 | 163797 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 804 | 13 | 10 | 9 | 0.1 | CN1C(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=O)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H]1CS | 10.1021/acs.jmedchem.8b00336 | ||
| CHEMBL4073428 | 163797 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 804 | 13 | 10 | 9 | 0.1 | CN1C(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=O)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H]1CS | 10.1021/acs.jmedchem.8b00336 | ||
| 71450913 | 85766 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 712 | 12 | 10 | 7 | 0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)/C=C\[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm049429h | ||
| CHEMBL2113067 | 85766 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 712 | 12 | 10 | 7 | 0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)/C=C\[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm049429h | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.7b01322 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.7b01322 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.7b01322 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.7b01322 | ||
| 137638861 | 163760 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 959 | 18 | 15 | 13 | -2.6 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4073066 | 163760 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 959 | 18 | 15 | 13 | -2.6 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| 138501433 | 189892 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.6 | Cc1ccnc([C@@H]2CCCN2Cc2cc(N3CCN(C)CC3)nc(C)n2)c1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4794732 | 189892 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.6 | Cc1ccnc([C@@H]2CCCN2Cc2cc(N3CCN(C)CC3)nc(C)n2)c1 | 10.1016/j.ejmech.2020.112537 | ||
| 5943987 | 205384 | 4 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 462 | 12 | 1 | 6 | 6.2 | CCN(CC)CCCC(C)Nc1cc(/C=C/c2ccc([N+](=O)[O-])cc2)nc2cc(OC)ccc12 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL578702 | 205384 | 4 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 462 | 12 | 1 | 6 | 6.2 | CCN(CC)CCCC(C)Nc1cc(/C=C/c2ccc([N+](=O)[O-])cc2)nc2cc(OC)ccc12 | 10.1016/j.ejmech.2018.02.043 | ||
| 155516872 | 176904 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 2847 | 101 | 39 | 41 | -10.8 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4443891 | 176904 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 2847 | 101 | 39 | 41 | -10.8 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| 10126019 | 14500 | 20 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| CHEMBL1088913 | 14500 | 20 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1021/jm100073m | ||
| 137637266 | 162713 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1019 | 18 | 14 | 12 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4061034 | 162713 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 1019 | 18 | 14 | 12 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| 138501462 | 189050 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.3 | Cc1nc(CN2CCC[C@H]2c2ccccn2)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4783831 | 189050 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.3 | Cc1nc(CN2CCC[C@H]2c2ccccn2)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| 71716524 | 94981 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 481 | 11 | 7 | 3 | 5.3 | N=C(NCCCCNCCCNC(=N)Nc1cccc2ccccc12)Nc1cccc2ccccc12 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2347626 | 94981 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 481 | 11 | 7 | 3 | 5.3 | N=C(NCCCCNCCCNC(=N)Nc1cccc2ccccc12)Nc1cccc2ccccc12 | 10.1016/j.bmcl.2013.01.107 | ||
| 155528475 | 178097 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 1496 | 53 | 21 | 22 | -5.9 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)NCCOCCOCCOCCC(=O)N[C@@H](CCCCN)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4461110 | 178097 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 1496 | 53 | 21 | 22 | -5.9 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)NCCOCCOCCOCCC(=O)N[C@@H](CCCCN)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| 44561525 | 179461 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 572 | 13 | 9 | 5 | 2.8 | CC(C)C[C@@H](NC(=N)N)C(=O)Nc1ccc2c(c1)cc(C(=O)NCCc1c[nH]c3ccccc13)n2CCCNC(=N)N | 10.1016/j.bmcl.2008.05.092 | ||
| CHEMBL450041 | 179461 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 572 | 13 | 9 | 5 | 2.8 | CC(C)C[C@@H](NC(=N)N)C(=O)Nc1ccc2c(c1)cc(C(=O)NCCc1c[nH]c3ccccc13)n2CCCNC(=N)N | 10.1016/j.bmcl.2008.05.092 | ||
| CHEMBL3581262 | 218558 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | None | None | None | C[C@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O | 10.1021/acs.jmedchem.5b00216 | ||||
| CHEMBL3894327 | 219203 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 25147749 | 8875 | 18 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| 2899 | 8875 | 18 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| 138501726 | 187660 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 392 | 5 | 0 | 6 | 3.0 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)nc(C3CC3)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4757478 | 187660 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 392 | 5 | 0 | 6 | 3.0 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)nc(C3CC3)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| 138501722 | 188081 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 367 | 4 | 1 | 7 | 1.7 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)nc(N)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4762385 | 188081 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 367 | 4 | 1 | 7 | 1.7 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)nc(N)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| 155534587 | 178740 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 3023 | 113 | 39 | 45 | -10.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)NCCOCCOCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4470663 | 178740 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 3023 | 113 | 39 | 45 | -10.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)NCCOCCOCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| 155542701 | 179935 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 2855 | 101 | 48 | 40 | -13.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)CCCCCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CS)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4521504 | 179935 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 2855 | 101 | 48 | 40 | -13.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)CCCCCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CS)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL374421 | 218979 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | CN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H]1CCCNC(=N)N | 10.1021/jm0607350 | ||||
| 137632745 | 163349 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 484 | 14 | 5 | 10 | 2.4 | Cc1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4068500 | 163349 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 484 | 14 | 5 | 10 | 2.4 | Cc1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL3942093 | 219251 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL192685 | 215870 | 1 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm050009h | ||||
| CHEMBL2180080 | 215870 | 1 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm050009h | ||||
| CHEMBL384429 | 219105 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | C[C@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm0607350 | ||||
| CHEMBL3581261 | 218557 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O | 10.1021/acs.jmedchem.5b00216 | ||||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 138501435 | 189926 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.6 | Cc1cccc([C@@H]2CCCN2Cc2cc(N3CCN(C)CC3)nc(C)n2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4795219 | 189926 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.6 | Cc1cccc([C@@H]2CCCN2Cc2cc(N3CCN(C)CC3)nc(C)n2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL193217 | 215877 | 1 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCN=C(N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||||
| CHEMBL2012653 | 215907 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)C1)C(=O)O | 10.1021/ml200084n | ||||
| 138501727 | 189354 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 437 | 5 | 0 | 8 | 2.0 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)nc(N3CCOCC3)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4787898 | 189354 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 437 | 5 | 0 | 8 | 2.0 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)nc(N3CCOCC3)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm801065q | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm801065q | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm801065q | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm801065q | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm801065q | ||
| 138501721 | 186327 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 382 | 5 | 0 | 7 | 2.1 | COc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4741655 | 186327 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 382 | 5 | 0 | 7 | 2.1 | COc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 138501445 | 187513 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 380 | 5 | 0 | 6 | 2.7 | CCc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4755917 | 187513 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 380 | 5 | 0 | 6 | 2.7 | CCc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 155537468 | 179071 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 3199 | 125 | 39 | 49 | -10.6 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)NCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4474901 | 179071 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 3199 | 125 | 39 | 49 | -10.6 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)NCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL3896146 | 219207 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 25178136 | 195719 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | C1=C(CS/C(=N\C2CCCCCC2)NC2CCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL508054 | 195719 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | C1=C(CS/C(=N\C2CCCCCC2)NC2CCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL5280362 | 200843 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 2876 | 100 | 48 | 42 | -16.4 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N(CCCCCC(=O)O)[C@@H](CCCCN[C@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@H](C)O)[C@H](C)O)C(N)=O | 10.1016/j.ejmech.2022.114797 | ||
| 137637238 | 162656 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 555 | 17 | 5 | 11 | 2.0 | Cc1cc(NC2CCN(CCC(N)=O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4060426 | 162656 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 555 | 17 | 5 | 11 | 2.0 | Cc1cc(NC2CCN(CCC(N)=O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 57343965 | 110604 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.4 | NCCCCN(C[C@@H]1NCCc2ccccc21)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091678 | 110604 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.4 | NCCCCN(C[C@@H]1NCCc2ccccc21)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL375850 | 219003 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CN1C(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1Cc1ccc2ccccc2c1 | 10.1021/jm0607350 | ||||
| 9959718 | 14566 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 488 | 9 | 2 | 5 | 5.7 | c1ccc(CNCc2ccc(CN(Cc3nc4ccccc4[nH]3)C3CCCc4cccnc43)cc2)nc1 | 10.1021/jm100073m | ||
| CHEMBL1089434 | 14566 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 488 | 9 | 2 | 5 | 5.7 | c1ccc(CNCc2ccc(CN(Cc3nc4ccccc4[nH]3)C3CCCc4cccnc43)cc2)nc1 | 10.1021/jm100073m | ||
| 70694124 | 81331 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 740 | 12 | 11 | 7 | 1.4 | C/C1=C(/C)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=N)N | 10.1021/jm2016914 | ||
| CHEMBL2029610 | 81331 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 740 | 12 | 11 | 7 | 1.4 | C/C1=C(/C)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=N)N | 10.1021/jm2016914 | ||
| 155517575 | 176972 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1ccccc1CNCC1CCN(Cc2ccccc2Cl)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4444949 | 176972 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1ccccc1CNCC1CCN(Cc2ccccc2Cl)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155529936 | 178252 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 376 | 6 | 1 | 2 | 5.3 | Cc1cccc(CNCC2CCN(Cc3c(Cl)cccc3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4463564 | 178252 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 376 | 6 | 1 | 2 | 5.3 | Cc1cccc(CNCC2CCN(Cc3c(Cl)cccc3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155557524 | 181445 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 372 | 6 | 1 | 4 | 4.1 | Clc1ccccc1CN1CCC(CNCc2ccc3c(c2)OCO3)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4558842 | 181445 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 372 | 6 | 1 | 4 | 4.1 | Clc1ccccc1CN1CCC(CNCc2ccc3c(c2)OCO3)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL5288597 | 201211 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 345 | 5 | 2 | 4 | 1.7 | Cc1c[nH]c(CN2CCC(N3CCCC(C(=O)NC4CC4)C3)CC2)n1 | 10.1021/acs.jmedchem.6b01309 | ||
| 10146 | 8051 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 10.1016/j.ejmech.2018.10.060 | ||
| 137321154 | 8051 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4596188 | 8051 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155521148 | 177354 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 396 | 6 | 1 | 2 | 5.6 | Clc1ccccc1CN1CCC(CNCc2cccc(Cl)c2Cl)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4450496 | 177354 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 396 | 6 | 1 | 2 | 5.6 | Clc1ccccc1CN1CCC(CNCc2cccc(Cl)c2Cl)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155530935 | 178369 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 324 | 7 | 1 | 3 | 3.7 | COc1ccccc1CN1CCC(CNCc2ccccc2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4465129 | 178369 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 324 | 7 | 1 | 3 | 3.7 | COc1ccccc1CN1CCC(CNCc2ccccc2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155562280 | 182616 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1cccc(CNCC2CCN(Cc3cccc(Cl)c3)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4585203 | 182616 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1cccc(CNCC2CCN(Cc3cccc(Cl)c3)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| 138501441 | 189428 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 394 | 5 | 0 | 6 | 3.3 | CC(C)c1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4788777 | 189428 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 394 | 5 | 0 | 6 | 3.3 | CC(C)c1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL374862 | 218987 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CN1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0607350 | ||||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 72535446 | 150593 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 512 | 9 | 2 | 7 | 3.8 | O=C(O)Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)C3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3901316 | 150593 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 512 | 9 | 2 | 7 | 3.8 | O=C(O)Cn1c2ccccc2c2ccnc(CN(CCCN3CCNCC3)C3CCCc4cccnc43)c21 | nan | ||
| CHEMBL5280204 | 200834 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 2876 | 100 | 48 | 42 | -16.4 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N(CCCCCC(=O)O)[C@H](CCCCN[C@@H](CS)C(=O)N[C@@H](C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O)[C@@H](C)O)C(N)=O | 10.1016/j.ejmech.2022.114797 | ||
| 71589166 | 94978 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 381 | 11 | 7 | 3 | 3.0 | N=C(NCCCCNCCCNC(=N)Nc1ccccc1)Nc1ccccc1 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2347623 | 94978 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 381 | 11 | 7 | 3 | 3.0 | N=C(NCCCCNCCCNC(=N)Nc1ccccc1)Nc1ccccc1 | 10.1016/j.bmcl.2013.01.107 | ||
| 145964516 | 170898 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 324 | 4 | 1 | 6 | 1.6 | c1cnc2c(c1)CCCC2N(Cc1ccncn1)N1CCNCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4209872 | 170898 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 324 | 4 | 1 | 6 | 1.6 | c1cnc2c(c1)CCCC2N(Cc1ccncn1)N1CCNCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 134139204 | 153368 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 3081 | 81 | 50 | 42 | -9.9 | CCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC(CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O)C(C)C | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3923084 | 153368 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 3081 | 81 | 50 | 42 | -9.9 | CCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC(CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O)C(C)C | 10.1021/acs.jmedchem.6b00566 | ||
| 162669638 | 189357 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 454 | 4 | 2 | 6 | 5.5 | CCOC(=O)c1c(NC(=S)Nc2ccc3c(c2)OC(F)(F)O3)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL4787966 | 189357 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 454 | 4 | 2 | 6 | 5.5 | CCOC(=O)c1c(NC(=S)Nc2ccc3c(c2)OC(F)(F)O3)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| 25178563 | 181024 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 434 | 4 | 1 | 5 | 6.2 | C1=C(CS/C(=N\C2CCCCCCC2)NC2CCCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL454896 | 181024 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 434 | 4 | 1 | 5 | 6.2 | C1=C(CS/C(=N\C2CCCCCCC2)NC2CCCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| 11648393 | 170642 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 465 | 16 | 3 | 5 | 4.0 | CCCN(CCC)CCCCNCc1ccc(C(=O)N(Cc2ncc[nH]2)Cc2ncc[nH]2)cc1 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL4206706 | 170642 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 465 | 16 | 3 | 5 | 4.0 | CCCN(CCC)CCCCNCc1ccc(C(=O)N(Cc2ncc[nH]2)Cc2ncc[nH]2)cc1 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL426635 | 220126 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | NC(=O)C[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||||
| 44561524 | 190581 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 519 | 10 | 5 | 4 | 5.3 | N=C(N)NCCc1cc2cc(NC(=O)CCc3ccc(O)cc3)ccc2n1CCc1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.05.092 | ||
| CHEMBL480502 | 190581 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 519 | 10 | 5 | 4 | 5.3 | N=C(N)NCCc1cc2cc(NC(=O)CCc3ccc(O)cc3)ccc2n1CCc1ccc2ccccc2c1 | 10.1016/j.bmcl.2008.05.092 | ||
| CHEMBL414085 | 168563 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 1982 | 47 | 31 | 26 | -6.6 | C[C@H]1/C=C\[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)C(CCCNC(N)=O)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1016/s0960-894x(02)00041-0 | ||
| 138501437 | 189946 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.6 | Cc1ccc([C@@H]2CCCN2Cc2cc(N3CCN(C)CC3)nc(C)n2)nc1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4795444 | 189946 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.6 | Cc1ccc([C@@H]2CCCN2Cc2cc(N3CCN(C)CC3)nc(C)n2)nc1 | 10.1016/j.ejmech.2020.112537 | ||
| 25178565 | 183520 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL460298 | 183520 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| 25178138 | 201706 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 392 | 4 | 1 | 5 | 5.0 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL541728 | 201706 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 392 | 4 | 1 | 5 | 5.0 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL2012532 | 215904 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)C1)C(=O)O | 10.1021/ml200084n | ||||
| 71589167 | 94979 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 499 | 12 | 8 | 3 | 4.8 | N=C(NCCCCN(CCCNC(=N)Nc1ccccc1)C(=N)Nc1ccccc1)Nc1ccccc1 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2347624 | 94979 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 499 | 12 | 8 | 3 | 4.8 | N=C(NCCCCN(CCCNC(=N)Nc1ccccc1)C(=N)Nc1ccccc1)Nc1ccccc1 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL3894964 | 219205 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 155551439 | 180767 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 2876 | 99 | 49 | 42 | -16.5 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)NCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)[C@@H](C)O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4542285 | 180767 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 2876 | 99 | 49 | 42 | -16.5 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)NCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)[C@@H](C)O | 10.1016/j.ejmech.2019.03.056 | ||
| 57345320 | 10604 | 9 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| 9882 | 10604 | 9 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL3091687 | 10604 | 9 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 138501452 | 186861 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 428 | 5 | 0 | 6 | 3.8 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)nc(-c3ccccc3)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4748070 | 186861 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 428 | 5 | 0 | 6 | 3.8 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)nc(-c3ccccc3)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| 11176403 | 8874 | 1 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| 2900 | 8874 | 1 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| CHEMBL452864 | 8874 | 1 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| 76335355 | 110608 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 406 | 8 | 2 | 4 | 3.4 | CC(=O)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091684 | 110608 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 406 | 8 | 2 | 4 | 3.4 | CC(=O)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 145975925 | 170654 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 368 | 6 | 1 | 7 | 1.3 | OCCN1CCN(N(Cc2ccncn2)C2CCCc3cccnc32)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4206872 | 170654 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 368 | 6 | 1 | 7 | 1.3 | OCCN1CCN(N(Cc2ccncn2)C2CCCc3cccnc32)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL2029613 | 215928 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | None | None | None | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCNC(=N)N | 10.1021/jm2016914 | ||||
| 57345321 | 130674 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.0 | NCCCCN(C[C@@H]1CN(Cc2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| CHEMBL3627792 | 130674 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.0 | NCCCCN(C[C@@H]1CN(Cc2ccccc2)CCN1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2015.04.036 | ||
| 46206136 | 14739 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 488 | 9 | 2 | 5 | 5.7 | c1ccc(CNCc2ccc(CN(Cc3nc4ccccc4[nH]3)[C@@H]3CCCc4cccnc43)cc2)nc1 | 10.1021/jm100073m | ||
| CHEMBL1090509 | 14739 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 488 | 9 | 2 | 5 | 5.7 | c1ccc(CNCc2ccc(CN(Cc3nc4ccccc4[nH]3)[C@@H]3CCCc4cccnc43)cc2)nc1 | 10.1021/jm100073m | ||
| 138501796 | 190256 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 420 | 4 | 0 | 6 | 3.2 | CN1CCN(c2cc(CN(C)[C@H]3CCCc4cccnc43)nc(C(F)(F)F)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4799317 | 190256 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 420 | 4 | 0 | 6 | 3.2 | CN1CCN(c2cc(CN(C)[C@H]3CCCc4cccnc43)nc(C(F)(F)F)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 56648035 | 77383 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 1541 | 31 | 18 | 16 | 1.2 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 91930553 | 77383 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 1541 | 31 | 18 | 16 | 1.2 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949738 | 77383 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 1541 | 31 | 18 | 16 | 1.2 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL218806 | 216179 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | CN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H]1CCCNC(=N)N | 10.1021/jm0607350 | ||||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1128/aac.01727-08 | ||
| 46830205 | 15549 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 388 | 7 | 0 | 4 | 4.6 | CN(C)CCCc1c(CN(C)[C@H]2CCCc3cccnc32)ncc2ccccc12 | 10.1016/j.bmcl.2010.03.118 | ||
| CHEMBL1096504 | 15549 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 388 | 7 | 0 | 4 | 4.6 | CN(C)CCCc1c(CN(C)[C@H]2CCCc3cccnc32)ncc2ccccc12 | 10.1016/j.bmcl.2010.03.118 | ||
| 155521909 | 177462 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 578 | 9 | 3 | 8 | 4.1 | c1ccc(CN(Cc2ccnc(-c3cccc(CN4CCCNCCNCCCNCC4)c3)c2)Cc2ccccn2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| CHEMBL4451705 | 177462 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 578 | 9 | 3 | 8 | 4.1 | c1ccc(CN(Cc2ccnc(-c3cccc(CN4CCCNCCNCCCNCC4)c3)c2)Cc2ccccn2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| CHEMBL438934 | 220592 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | COc1ccc(C[C@H]2NC(=O)[C@@H]3CCCN3C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)CSSC[C@H](C(=O)N[C@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC2=O)cc1 | 10.1021/jm049429h | ||||
| 138501632 | 186801 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 392 | 4 | 0 | 6 | 3.0 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN3CCC[C@@H]3C2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4747341 | 186801 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 392 | 4 | 0 | 6 | 3.0 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN3CCC[C@@H]3C2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 72546294 | 110605 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 392 | 8 | 1 | 4 | 3.8 | CN(C)CCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091681 | 110605 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 392 | 8 | 1 | 4 | 3.8 | CN(C)CCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 11256587 | 9240 | 59 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/ml400183q | ||
| 8580 | 9240 | 59 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/ml400183q | ||
| CHEMBL518924 | 9240 | 59 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/ml400183q | ||
| DB05501 | 9240 | 59 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/ml400183q | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/ml400183q | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/ml400183q | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/ml400183q | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/ml400183q | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/ml400183q | ||
| CHEMBL3914095 | 219228 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 71716526 | 94990 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 874 | 17 | 10 | 4 | 11.1 | N=C(NCCCN(CCCCN(CCCNC(=N)Nc1ccc2ccccc2c1)C(=N)Nc1ccc2ccccc2c1)C(=N)Nc1ccc2ccccc2c1)Nc1ccc2ccccc2c1 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2347635 | 94990 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 874 | 17 | 10 | 4 | 11.1 | N=C(NCCCN(CCCCN(CCCNC(=N)Nc1ccc2ccccc2c1)C(=N)Nc1ccc2ccccc2c1)C(=N)Nc1ccc2ccccc2c1)Nc1ccc2ccccc2c1 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL5275177 | 200621 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 340 | 7 | 1 | 3 | 3.4 | Cc1nc(CN(C)CC2CCCN(CCc3ccccc3C)C2)c[nH]1 | 10.1021/acs.jmedchem.6b01309 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 44561446 | 176264 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 570 | 10 | 8 | 5 | 2.5 | N=C(N)NCCCn1c(C(=O)NCCc2c[nH]c3ccccc23)cc2cc(NC(=O)C3CCN(C(=N)N)CC3)ccc21 | 10.1016/j.bmcl.2008.05.092 | ||
| CHEMBL443092 | 176264 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 570 | 10 | 8 | 5 | 2.5 | N=C(N)NCCCn1c(C(=O)NCCc2c[nH]c3ccccc23)cc2cc(NC(=O)C3CCN(C(=N)N)CC3)ccc21 | 10.1016/j.bmcl.2008.05.092 | ||
| 44561483 | 185965 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 516 | 11 | 9 | 5 | 1.4 | N=C(N)NCCCn1c(C(=O)NCCc2c[nH]c3ccccc23)cc2cc(NC(=O)CNC(=N)N)ccc21 | 10.1016/j.bmcl.2008.05.092 | ||
| CHEMBL472323 | 185965 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 516 | 11 | 9 | 5 | 1.4 | N=C(N)NCCCn1c(C(=O)NCCc2c[nH]c3ccccc23)cc2cc(NC(=O)CNC(=N)N)ccc21 | 10.1016/j.bmcl.2008.05.092 | ||
| CHEMBL414085 | 168563 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 1982 | 47 | 31 | 26 | -6.6 | C[C@H]1/C=C\[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)C(CCCNC(N)=O)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1016/s0960-894x(02)00041-0 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.111914 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.111914 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.111914 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.111914 | ||
| 56648036 | 77393 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 2013 | 43 | 23 | 25 | -2.8 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CC(CC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C)NC(=O)CCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/jm2009716 | ||
| 91930561 | 77393 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 2013 | 43 | 23 | 25 | -2.8 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CC(CC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C)NC(=O)CCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/jm2009716 | ||
| CHEMBL1949888 | 77393 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 2013 | 43 | 23 | 25 | -2.8 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CC(CC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C)NC(=O)CCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 | 10.1021/jm2009716 | ||
| 134138747 | 154234 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 3170 | 84 | 51 | 43 | -9.6 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C/C=C/c1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3930215 | 154234 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 3170 | 84 | 51 | 43 | -9.6 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C/C=C/c1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| 70695561 | 84755 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 698 | 12 | 10 | 7 | 1.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)/C=C\[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm049429h | ||
| CHEMBL2096822 | 84755 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 698 | 12 | 10 | 7 | 1.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)/C=C\[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm049429h | ||
| CHEMBL5273456 | 200544 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 583 | 21 | 6 | 6 | 5.9 | c1c(CNCCCNC2CCCCC2)cc(CNCCCNC2CCCCC2)cc1CNCCCNC1CCCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| 155539331 | 179619 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 328 | 6 | 1 | 2 | 4.3 | Clc1ccccc1CN1CCC(CNCc2ccccc2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4514484 | 179619 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 328 | 6 | 1 | 2 | 4.3 | Clc1ccccc1CN1CCC(CNCc2ccccc2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155554725 | 181387 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 344 | 6 | 2 | 3 | 4.0 | Oc1ccc(CNCC2CCN(Cc3ccccc3Cl)CC2)cc1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4557428 | 181387 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 344 | 6 | 2 | 3 | 4.0 | Oc1ccc(CNCC2CCN(Cc3ccccc3Cl)CC2)cc1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155566844 | 183389 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 362 | 6 | 1 | 2 | 5.0 | Clc1cccc(CNCC2CCN(Cc3ccccc3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4585865 | 183389 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 362 | 6 | 1 | 2 | 5.0 | Clc1cccc(CNCC2CCN(Cc3ccccc3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4597725 | 183389 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 362 | 6 | 1 | 2 | 5.0 | Clc1cccc(CNCC2CCN(Cc3ccccc3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155523400 | 177529 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1cccc(CNCC2CCN(Cc3ccccc3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4452433 | 177529 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 342 | 6 | 1 | 2 | 4.7 | Cc1cccc(CNCC2CCN(Cc3ccccc3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155561098 | 181758 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 334 | 6 | 1 | 2 | 4.7 | Clc1ccccc1CN1CCC(CNCC2CCCCC2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4566356 | 181758 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 334 | 6 | 1 | 2 | 4.7 | Clc1ccccc1CN1CCC(CNCC2CCCCC2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 138501614 | 189161 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.3 | Cc1nc(CN2CCCC2c2ccccn2)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4785166 | 189161 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.3 | Cc1nc(CN2CCCC2c2ccccn2)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| 155546536 | 180339 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 8 | 3 | 7 | 3.0 | c1ccc(CN(Cc2ccc(CN3CCCNCCNCCCNCC3)cc2)Cc2ccccn2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| CHEMBL4532299 | 180339 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 8 | 3 | 7 | 3.0 | c1ccc(CN(Cc2ccc(CN3CCCNCCNCCCNCC3)cc2)Cc2ccccn2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| 5275847 | 85770 | 1 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 715 | 12 | 11 | 8 | -0.8 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm049429h | ||
| CHEMBL2113071 | 85770 | 1 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 715 | 12 | 11 | 8 | -0.8 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm049429h | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114150 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114797 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114797 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114797 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114797 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2022.114797 | ||
| 145976496 | 170335 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 352 | 5 | 0 | 6 | 2.3 | CCN1CCN(N(Cc2ccncn2)C2CCCc3cccnc32)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4203042 | 170335 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 352 | 5 | 0 | 6 | 2.3 | CCN1CCN(N(Cc2ccncn2)C2CCCc3cccnc32)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 134158362 | 165392 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 904 | 14 | 13 | 11 | -0.2 | C[C@H](NC(=O)c1cccc(NC(=N)N)c1)C(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01830 | ||
| CHEMBL4092239 | 165392 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 904 | 14 | 13 | 11 | -0.2 | C[C@H](NC(=O)c1cccc(NC(=N)N)c1)C(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01830 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| 25147749 | 8875 | 18 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| 2899 | 8875 | 18 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| 138501659 | 189381 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 391 | 4 | 0 | 7 | 2.3 | Cc1nc(CN(C)C2CCCc3cccnc32)c(C#N)c(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4788248 | 189381 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 391 | 4 | 0 | 7 | 2.3 | Cc1nc(CN(C)C2CCCc3cccnc32)c(C#N)c(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 56648231 | 77387 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 1653 | 39 | 18 | 16 | 4.3 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCCCCCCCCCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 91930556 | 77387 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 1653 | 39 | 18 | 16 | 4.3 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCCCCCCCCCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949741 | 77387 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 1653 | 39 | 18 | 16 | 4.3 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCCCCCCCCCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL192368 | 215868 | 1 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | N=C(N)NCCCC[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||||
| 70694123 | 81329 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 712 | 12 | 11 | 7 | 0.6 | N=C(N)NCCC[C@H]1/C=C/[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm2016914 | ||
| CHEMBL2029608 | 81329 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 712 | 12 | 11 | 7 | 0.6 | N=C(N)NCCC[C@H]1/C=C/[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm2016914 | ||
| 70694478 | 82238 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=N)[C@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/ml200047e | ||
| CHEMBL2042234 | 82238 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=N)[C@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/ml200047e | ||
| CHEMBL3923282 | 219234 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||||
| 155558653 | 181541 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 2759 | 97 | 37 | 39 | -9.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(=O)N[C@H](CCCCN)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](C)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4561023 | 181541 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 2759 | 97 | 37 | 39 | -9.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(=O)N[C@H](CCCCN)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](C)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL3955461 | 219268 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 118965334 | 163499 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 14 | 5 | 10 | 2.1 | c1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4070263 | 163499 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 14 | 5 | 10 | 2.1 | c1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 118965395 | 162992 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 613 | 19 | 6 | 12 | 1.7 | Cc1cc(NC2CCN(C(=O)CCNCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4064397 | 162992 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 613 | 19 | 6 | 12 | 1.7 | Cc1cc(NC2CCN(C(=O)CCNCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 57345320 | 10604 | 9 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| 9882 | 10604 | 9 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| CHEMBL3091687 | 10604 | 9 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| 5275843 | 220457 | 31 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmcl.2008.05.092 | ||||
| CHEMBL2180076 | 220457 | 31 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmcl.2008.05.092 | ||||
| CHEMBL436283 | 220457 | 31 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmcl.2008.05.092 | ||||
| 132578414 | 156541 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 277 | 4 | 0 | 5 | 0.7 | c1cc(CN2CCOCC2)nc(CN2CCOCC2)c1 | 10.1016/j.bmc.2016.08.018 | ||
| CHEMBL3948266 | 156541 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 277 | 4 | 0 | 5 | 0.7 | c1cc(CN2CCOCC2)nc(CN2CCOCC2)c1 | 10.1016/j.bmc.2016.08.018 | ||
| 53321478 | 65213 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 298 | 8 | 1 | 4 | 3.1 | Cc1cccnc1CN(CCCCN)[C@@H](C)c1ccccn1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682998 | 65213 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 298 | 8 | 1 | 4 | 3.1 | Cc1cccnc1CN(CCCCN)[C@@H](C)c1ccccn1 | 10.1016/j.bmcl.2011.01.021 | ||
| 44418885 | 90102 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 743 | 12 | 12 | 8 | -0.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCNC(=N)N)NC1=O | 10.1021/jm0607350 | ||
| CHEMBL219135 | 90102 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 743 | 12 | 12 | 8 | -0.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCNC(=N)N)NC1=O | 10.1021/jm0607350 | ||
| CHEMBL3922941 | 219233 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL5266216 | 200252 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 459 | 15 | 4 | 6 | 4.4 | O=[N+]([O-])c1cc(CNCCCNC2CCCCC2)ccc1CNCCCNC1CCCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| 25181075 | 180204 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 392 | 4 | 0 | 5 | 4.9 | CN(/C(=N/C1CCCCC1)SCC1=CSC2=NCCN12)C1CCCCC1 | 10.1021/jm801065q | ||
| CHEMBL452868 | 180204 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 392 | 4 | 0 | 5 | 4.9 | CN(/C(=N/C1CCCCC1)SCC1=CSC2=NCCN12)C1CCCCC1 | 10.1021/jm801065q | ||
| 138501634 | 189177 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 410 | 8 | 1 | 7 | 2.8 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(NCCCN2CCOCC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4785495 | 189177 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 410 | 8 | 1 | 7 | 2.8 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(NCCCN2CCOCC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 10126019 | 14500 | 20 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.03.118 | ||
| CHEMBL1088913 | 14500 | 20 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.03.118 | ||
| 56955853 | 145502 | 1 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 501 | 12 | 5 | 7 | 4.8 | c1ccc2c(NC3CCNCC3)nc(NCc3ccc(CNCCCNC4CCCCC4)cc3)nc2c1 | 10.1016/j.ejmech.2018.02.043 | ||
| CHEMBL3779982 | 145502 | 1 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 501 | 12 | 5 | 7 | 4.8 | c1ccc2c(NC3CCNCC3)nc(NCc3ccc(CNCCCNC4CCCCC4)cc3)nc2c1 | 10.1016/j.ejmech.2018.02.043 | ||
| 137651859 | 164009 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 959 | 18 | 15 | 13 | -2.6 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4076358 | 164009 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 959 | 18 | 15 | 13 | -2.6 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| 162666072 | 189080 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 979 | 21 | 7 | 15 | 2.2 | CC1(C)CN2C(CS/C(N)=N\[C@H]3CC[C@H](CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@@H]4CC[C@@]5(O)[C@H]6Cc7ccc(O)c8c7[C@@]5(CCN6CC5CC5)[C@H]4O8)CC3)=CSC2=N1 | 10.1021/acsmedchemlett.0c00444 | ||
| CHEMBL4784104 | 189080 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 979 | 21 | 7 | 15 | 2.2 | CC1(C)CN2C(CS/C(N)=N\[C@H]3CC[C@H](CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@@H]4CC[C@@]5(O)[C@H]6Cc7ccc(O)c8c7[C@@]5(CCN6CC5CC5)[C@H]4O8)CC3)=CSC2=N1 | 10.1021/acsmedchemlett.0c00444 | ||
| CHEMBL266632 | 103785 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 1988 | 49 | 30 | 27 | -7.0 | C[C@H]1/C=C\[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CSCc2ccccc2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)C(CCCNC(N)=O)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1016/s0960-894x(02)00041-0 | ||
| CHEMBL3905094 | 219221 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 137640469 | 163859 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 1014 | 19 | 14 | 14 | -1.4 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4074277 | 163859 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 1014 | 19 | 14 | 14 | -1.4 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL1949730 | 215879 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=N)N | 10.1021/ml200047e | ||||
| 44561527 | 178614 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 606 | 13 | 9 | 5 | 3.0 | N=C(N)NCCCn1c(C(=O)NCCc2c[nH]c3ccccc23)cc2cc(NC(=O)[C@@H](Cc3ccccc3)NC(=N)N)ccc21 | 10.1016/j.bmcl.2008.05.092 | ||
| CHEMBL446868 | 178614 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 606 | 13 | 9 | 5 | 3.0 | N=C(N)NCCCn1c(C(=O)NCCc2c[nH]c3ccccc23)cc2cc(NC(=O)[C@@H](Cc3ccccc3)NC(=N)N)ccc21 | 10.1016/j.bmcl.2008.05.092 | ||
| 25178140 | 183521 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 364 | 4 | 1 | 5 | 4.2 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL460299 | 183521 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 364 | 4 | 1 | 5 | 4.2 | C1=C(CS/C(=N\C2CCCCC2)NC2CCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL2012651 | 215905 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)C1)C(=O)O | 10.1021/ml200084n | ||||
| 71719570 | 94989 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 874 | 17 | 10 | 4 | 11.1 | N=C(NCCCN(CCCCN(CCCNC(=N)Nc1cccc2ccccc12)C(=N)Nc1cccc2ccccc12)C(=N)Nc1cccc2ccccc12)Nc1cccc2ccccc12 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2347634 | 94989 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 874 | 17 | 10 | 4 | 11.1 | N=C(NCCCN(CCCCN(CCCNC(=N)Nc1cccc2ccccc12)C(=N)Nc1cccc2ccccc12)C(=N)Nc1cccc2ccccc12)Nc1cccc2ccccc12 | 10.1016/j.bmcl.2013.01.107 | ||
| 25178134 | 180942 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 350 | 4 | 1 | 5 | 3.8 | C1=C(CS/C(=N\C2CCCC2)NC2CCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL454689 | 180942 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 350 | 4 | 1 | 5 | 3.8 | C1=C(CS/C(=N\C2CCCC2)NC2CCCC2)N2CCN=C2S1 | 10.1021/jm801065q | ||
| 56648501 | 77394 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 2113 | 46 | 25 | 27 | -4.9 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)C[C@H](NC(=O)CCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 91930562 | 77394 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 2113 | 46 | 25 | 27 | -4.9 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)C[C@H](NC(=O)CCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949889 | 77394 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 2113 | 46 | 25 | 27 | -4.9 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)C[C@H](NC(=O)CCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 71525976 | 160268 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 453 | 7 | 3 | 8 | 3.1 | Cc1ccc(C(Nc2c(Nc3cccc(C(=O)N(C)C)c3O)c(=O)c2=O)C2(C)CCCO2)o1 | 10.1021/acs.jmedchem.5b01337 | ||
| CHEMBL3979652 | 160268 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 453 | 7 | 3 | 8 | 3.1 | Cc1ccc(C(Nc2c(Nc3cccc(C(=O)N(C)C)c3O)c(=O)c2=O)C2(C)CCCO2)o1 | 10.1021/acs.jmedchem.5b01337 | ||
| 155539331 | 179619 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 328 | 6 | 1 | 2 | 4.3 | Clc1ccccc1CN1CCC(CNCc2ccccc2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4514484 | 179619 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 328 | 6 | 1 | 2 | 4.3 | Clc1ccccc1CN1CCC(CNCc2ccccc2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 137660848 | 165880 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 599 | 19 | 6 | 12 | 1.4 | O=C(O)CNCCC(=O)N1CCC(Nc2ccnc(NCc3cn(CCCNCCCNC4CCCCC4)nn3)n2)CC1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4097496 | 165880 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 599 | 19 | 6 | 12 | 1.4 | O=C(O)CNCCC(=O)N1CCC(Nc2ccnc(NCc3cn(CCCNCCCNC4CCCCC4)nn3)n2)CC1 | 10.1021/acs.jmedchem.7b01322 | ||
| 56647830 | 77379 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1499 | 28 | 18 | 16 | -0.0 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 91930549 | 77379 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1499 | 28 | 18 | 16 | -0.0 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949734 | 77379 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1499 | 28 | 18 | 16 | -0.0 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 56648034 | 77382 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1513 | 29 | 18 | 16 | 0.4 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 91930552 | 77382 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1513 | 29 | 18 | 16 | 0.4 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949737 | 77382 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1513 | 29 | 18 | 16 | 0.4 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 57391612 | 77386 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1612 | 36 | 17 | 16 | 3.3 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCCCCCCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 91930555 | 77386 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1612 | 36 | 17 | 16 | 3.3 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCCCCCCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949740 | 77386 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1612 | 36 | 17 | 16 | 3.3 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCCCCCCCCCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 5275843 | 220457 | 31 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmc.2014.07.004 | ||||
| CHEMBL2180076 | 220457 | 31 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmc.2014.07.004 | ||||
| CHEMBL436283 | 220457 | 31 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmc.2014.07.004 | ||||
| CHEMBL219474 | 216194 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm0607350 | ||||
| 53344611 | 82232 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=N)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/ml200047e | ||
| CHEMBL2042118 | 82232 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=N)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/ml200047e | ||
| CHEMBL2180077 | 220456 | 1 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||||
| CHEMBL436097 | 220456 | 1 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||||
| 155545664 | 180245 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 578 | 9 | 3 | 8 | 4.1 | c1ccc(CN(Cc2ccc(-c3ncccc3CN3CCCNCCNCCCNCC3)cc2)Cc2ccccn2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| CHEMBL4529751 | 180245 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 578 | 9 | 3 | 8 | 4.1 | c1ccc(CN(Cc2ccc(-c3ncccc3CN3CCCNCCNCCCNCC3)cc2)Cc2ccccn2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| CHEMBL370001 | 218944 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm049429h | ||||
| 15959068 | 15067 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 431 | 6 | 0 | 5 | 5.1 | CC(C)N1CCC[C@H](Cn2c(CN(C)[C@H]3CCCc4cccnc43)nc3ccccc32)C1 | 10.1016/j.bmcl.2010.02.053 | ||
| CHEMBL1092637 | 15067 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 431 | 6 | 0 | 5 | 5.1 | CC(C)N1CCC[C@H](Cn2c(CN(C)[C@H]3CCCc4cccnc43)nc3ccccc32)C1 | 10.1016/j.bmcl.2010.02.053 | ||
| 70681869 | 82233 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=N)[C@@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/ml200047e | ||
| CHEMBL2042119 | 82233 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=N)[C@@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/ml200047e | ||
| 72546295 | 110606 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 406 | 9 | 2 | 4 | 4.3 | CC(C)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091682 | 110606 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 406 | 9 | 2 | 4 | 4.3 | CC(C)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 72546063 | 110614 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 445 | 9 | 1 | 6 | 4.1 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1cocn1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091691 | 110614 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 445 | 9 | 1 | 6 | 4.1 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1cocn1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 71680586 | 94987 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 706 | 16 | 9 | 4 | 8.2 | N=C(NCCCNCCCCN(CCCNC(=N)Nc1cccc2ccccc12)C(=N)Nc1cccc2ccccc12)Nc1cccc2ccccc12 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2347632 | 94987 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 706 | 16 | 9 | 4 | 8.2 | N=C(NCCCNCCCCN(CCCNC(=N)Nc1cccc2ccccc12)C(=N)Nc1cccc2ccccc12)Nc1cccc2ccccc12 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL3923282 | 219234 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||||
| CHEMBL5269411 | 200379 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 464 | 14 | 4 | 4 | 5.6 | c1ccc2c(CNCCCNC3CCCCC3)ccc(CNCCCNC3CCCCC3)c2c1 | 10.1016/j.ejmech.2020.112410 | ||
| 155542701 | 179935 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 2855 | 101 | 48 | 40 | -13.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)CCCCCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CS)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4521504 | 179935 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 2855 | 101 | 48 | 40 | -13.6 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)CCCCCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CS)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| 155521886 | 177400 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 2629 | 95 | 36 | 39 | -9.9 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4450987 | 177400 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 2629 | 95 | 36 | 39 | -9.9 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| 57345320 | 10604 | 9 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| 9882 | 10604 | 9 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL3091687 | 10604 | 9 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL373155 | 218953 | 1 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm050009h | ||||
| CHEMBL5290756 | 201289 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 2876 | 99 | 48 | 42 | -16.4 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N(CCCCCC(=O)O)[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](C(N)=O)[C@@H](C)O)[C@@H](C)O | 10.1016/j.ejmech.2022.114797 | ||
| 76309931 | 110610 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 435 | 8 | 2 | 4 | 3.5 | CN(C)C(=O)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091686 | 110610 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 435 | 8 | 2 | 4 | 3.5 | CN(C)C(=O)NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL424826 | 220104 | 1 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||||
| CHEMBL5273020 | 200524 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 2845 | 99 | 46 | 38 | -12.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N(CCCCCC(=O)O)[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114797 | ||
| 25147749 | 8875 | 18 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| 2899 | 8875 | 18 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| 477106 | 26146 | 2 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 514 | 4 | 4 | 8 | 1.9 | c1cc2nc(c1)CNCCN(Cc1ccc(CN3CCNCc4cccc(n4)CNCC3)cc1)CCNC2 | 10.1021/jm990211i | ||
| CHEMBL1202230 | 26146 | 2 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 514 | 4 | 4 | 8 | 1.9 | c1cc2nc(c1)CNCCN(Cc1ccc(CN3CCNCc4cccc(n4)CNCC3)cc1)CCNC2 | 10.1021/jm990211i | ||
| CHEMBL129183 | 26146 | 2 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 514 | 4 | 4 | 8 | 1.9 | c1cc2nc(c1)CNCCN(Cc1ccc(CN3CCNCc4cccc(n4)CNCC3)cc1)CCNC2 | 10.1021/jm990211i | ||
| 134150065 | 158429 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 2985 | 83 | 45 | 42 | -8.2 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3963915 | 158429 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 2985 | 83 | 45 | 42 | -8.2 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.03.056 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.03.056 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.03.056 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL3627930 | 218666 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCCNC(=O)CSC[C@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(=O)CS[C@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O)C(N)=O | 10.1016/j.bmc.2015.09.040 | ||||
| 50942118 | 63678 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 373 | 5 | 2 | 5 | 4.1 | NCc1cocc1N(Cc1nc2ccccc2[nH]1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644082 | 63678 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 373 | 5 | 2 | 5 | 4.1 | NCc1cocc1N(Cc1nc2ccccc2[nH]1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 76313651 | 110602 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.4 | NCCCCN(C[C@H]1NCCc2ccccc21)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091676 | 110602 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.4 | NCCCCN(C[C@H]1NCCc2ccccc21)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 137642595 | 165291 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 498 | 15 | 5 | 10 | 2.7 | CCc1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4091201 | 165291 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 498 | 15 | 5 | 10 | 2.7 | CCc1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL3581269 | 218562 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | None | None | None | C[C@@H]1C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N1C | 10.1021/acs.jmedchem.5b00216 | ||||
| 155554948 | 181125 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 2312 | 70 | 35 | 32 | -9.5 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4551153 | 181125 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 2312 | 70 | 35 | 32 | -9.5 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C | 10.1016/j.bmc.2016.08.062 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 44418878 | 144613 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 743 | 12 | 12 | 8 | -0.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm0607350 | ||
| CHEMBL375991 | 144613 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 743 | 12 | 12 | 8 | -0.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm0607350 | ||
| 11638842 | 205220 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 349 | 6 | 1 | 5 | 3.3 | CN(Cc1nc2ccccc2n1CCCN)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.02.053 | ||
| CHEMBL577268 | 205220 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 349 | 6 | 1 | 5 | 3.3 | CN(Cc1nc2ccccc2n1CCCN)C1CCCc2cccnc21 | 10.1016/j.bmcl.2010.02.053 | ||
| 137649371 | 164186 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 526 | 16 | 4 | 10 | 3.6 | CCCN1CCC(Nc2cc(C)nc(NCc3cn(CCCNCCCNC4CCCCC4)nn3)n2)CC1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4078499 | 164186 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 526 | 16 | 4 | 10 | 3.6 | CCCN1CCC(Nc2cc(C)nc(NCc3cn(CCCNCCCNC4CCCCC4)nn3)n2)CC1 | 10.1021/acs.jmedchem.7b01322 | ||
| 137646518 | 164606 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 500 | 15 | 5 | 11 | 2.1 | COc1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4083415 | 164606 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 500 | 15 | 5 | 11 | 2.1 | COc1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 155560189 | 181713 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 1449 | 47 | 24 | 20 | -6.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4565225 | 181713 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 1449 | 47 | 24 | 20 | -6.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL5290852 | 201294 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 457 | 15 | 4 | 5 | 4.6 | CN(C)c1cc(CNCCCNC2CCCCC2)ccc1CNCCCNC1CCCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| 134135404 | 150712 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 3244 | 83 | 51 | 43 | -8.1 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc2cc3ccccc3cc2c1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3902240 | 150712 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 3244 | 83 | 51 | 43 | -8.1 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc2cc3ccccc3cc2c1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| 11176403 | 8874 | 1 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| 2900 | 8874 | 1 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| CHEMBL452864 | 8874 | 1 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| CHEMBL5267316 | 200298 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 2876 | 99 | 48 | 42 | -16.4 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N(CCCCCC(=O)O)[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(N)=O)[C@H](C)O)[C@H](C)O | 10.1016/j.ejmech.2022.114797 | ||
| 44561487 | 197342 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 534 | 9 | 6 | 5 | 4.8 | N=C(N)NCCCn1c(C(=O)Nc2cccc3ccccc23)cc2cc(NC(=O)Cc3ccc(O)cc3)ccc21 | 10.1016/j.bmcl.2008.05.092 | ||
| CHEMBL518004 | 197342 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 534 | 9 | 6 | 5 | 4.8 | N=C(N)NCCCn1c(C(=O)Nc2cccc3ccccc23)cc2cc(NC(=O)Cc3ccc(O)cc3)ccc21 | 10.1016/j.bmcl.2008.05.092 | ||
| CHEMBL371993 | 218950 | 1 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | None | None | None | C[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm050009h | ||||
| 57345320 | 10604 | 9 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| 9882 | 10604 | 9 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| CHEMBL3091687 | 10604 | 9 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/ml400183q | ||
| 118724116 | 123182 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 2106 | 48 | 36 | 27 | -7.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)NC(=O)C(CCCNC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)C(CCCNC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm401823z | ||
| CHEMBL3360194 | 123182 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 2106 | 48 | 36 | 27 | -7.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)NC(=O)C(CCCNC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)C(CCCNC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm401823z | ||
| 135314141 | 163509 | 0 | None | - | 0 | Mouse | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 460 | 9 | 2 | 5 | 4.0 | C(=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)\CNCC1CCOCC1 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4070320 | 163509 | 0 | None | - | 0 | Mouse | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 460 | 9 | 2 | 5 | 4.0 | C(=C/CN(C[C@H]1Cc2ccccc2CN1)[C@H]1CCCc2cccnc21)\CNCC1CCOCC1 | 10.1021/acs.jmedchem.7b01420 | ||
| 72535523 | 161022 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 437 | 8 | 1 | 5 | 4.8 | C#CCn1c2ccccc2c2ccnc(CN(CCCCN)C3CCCc4cccnc43)c21 | nan | ||
| CHEMBL3986210 | 161022 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 437 | 8 | 1 | 5 | 4.8 | C#CCn1c2ccccc2c2ccnc(CN(CCCCN)C3CCCc4cccnc43)c21 | nan | ||
| 68791630 | 152962 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 526 | 9 | 1 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCOCC3)c12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3919988 | 152962 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 526 | 9 | 1 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)N3CCOCC3)c12)C1CCCc2cccnc21 | nan | ||
| CHEMBL2012524 | 215896 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)C1)C(=O)O | 10.1021/ml200084n | ||||
| 155548895 | 181008 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 577 | 9 | 3 | 7 | 4.7 | c1ccc(CN(Cc2ccc(-c3ccccc3CN3CCCNCCNCCCNCC3)cc2)Cc2ccccn2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| CHEMBL4548792 | 181008 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 577 | 9 | 3 | 7 | 4.7 | c1ccc(CN(Cc2ccc(-c3ccccc3CN3CCCNCCNCCCNCC3)cc2)Cc2ccccn2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| 77955572 | 157322 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 511 | 10 | 2 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CCN3CCNCC3)c12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3954720 | 157322 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 511 | 10 | 2 | 7 | 4.1 | NCCCCN(Cc1nccc2c3ccccc3n(CCN3CCNCC3)c12)C1CCCc2cccnc21 | nan | ||
| 72535462 | 160428 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 456 | 9 | 2 | 6 | 3.7 | NCCCCN(Cc1nccc2c3ccccc3n(CC(N)=O)c12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3981053 | 160428 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 456 | 9 | 2 | 6 | 3.7 | NCCCCN(Cc1nccc2c3ccccc3n(CC(N)=O)c12)C1CCCc2cccnc21 | nan | ||
| 25147749 | 8875 | 18 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 2899 | 8875 | 18 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 70696255 | 81330 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 726 | 12 | 11 | 7 | 1.0 | C/C1=C\[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm2016914 | ||
| CHEMBL2029609 | 81330 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 726 | 12 | 11 | 7 | 1.0 | C/C1=C\[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm2016914 | ||
| CHEMBL440638 | 175967 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 1992 | 47 | 30 | 26 | -6.5 | C[C@H]1/C=C\[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)C(CCCNC(N)=O)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1016/s0960-894x(02)00041-0 | ||
| CHEMBL440998 | 176010 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 1981 | 47 | 31 | 26 | -7.2 | C[C@H]1/C=C\[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)NC(=O)C(CCCNC(N)=O)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1016/s0960-894x(02)00041-0 | ||
| 10146 | 8051 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 10.1016/j.ejmech.2018.10.060 | ||
| 137321154 | 8051 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4596188 | 8051 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155513323 | 183033 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 378 | 6 | 1 | 2 | 5.5 | Clc1ccccc1CN1CCC(CNCc2ccc3ccccc3c2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4438705 | 183033 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 378 | 6 | 1 | 2 | 5.5 | Clc1ccccc1CN1CCC(CNCc2ccc3ccccc3c2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4594891 | 183033 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 378 | 6 | 1 | 2 | 5.5 | Clc1ccccc1CN1CCC(CNCc2ccc3ccccc3c2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155542313 | 179901 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 2223 | 71 | 34 | 31 | -9.1 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCC[C@@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4520732 | 179901 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 2223 | 71 | 34 | 31 | -9.1 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCC[C@@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| 138501642 | 189088 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 406 | 6 | 0 | 6 | 3.2 | Cc1nc(CN(CC2CC2)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4784173 | 189088 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 406 | 6 | 0 | 6 | 3.2 | Cc1nc(CN(CC2CC2)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.03.056 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.03.056 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.03.056 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2019.03.056 | ||
| 71589203 | 94980 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 674 | 17 | 10 | 4 | 6.5 | N=C(NCCCN(CCCCN(CCCNC(=N)Nc1ccccc1)C(=N)Nc1ccccc1)C(=N)Nc1ccccc1)Nc1ccccc1 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2347625 | 94980 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 674 | 17 | 10 | 4 | 6.5 | N=C(NCCCN(CCCCN(CCCNC(=N)Nc1ccccc1)C(=N)Nc1ccccc1)C(=N)Nc1ccccc1)Nc1ccccc1 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL3901189 | 219217 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.6b00695 | ||||
| CHEMBL3923282 | 219234 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.6b00695 | ||||
| CHEMBL3901189 | 219217 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||||
| 5278945 | 75075 | 1 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 807 | 14 | 11 | 10 | -0.3 | N=C(N)NCCC(=O)N[C@H]1CSSC[C@H](C(=O)NCCc2ccc(O)cc2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||
| CHEMBL191639 | 75075 | 1 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 807 | 14 | 11 | 10 | -0.3 | N=C(N)NCCC(=O)N[C@H]1CSSC[C@H](C(=O)NCCc2ccc(O)cc2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||
| 155560189 | 181713 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 1449 | 47 | 24 | 20 | -6.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(N)=O | 10.1016/j.ejmech.2022.114797 | ||
| CHEMBL4565225 | 181713 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 1449 | 47 | 24 | 20 | -6.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(N)=O | 10.1016/j.ejmech.2022.114797 | ||
| 134816893 | 174294 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4214960 | 174294 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4299893 | 174294 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 44400298 | 131730 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 700 | 12 | 10 | 7 | 0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||
| CHEMBL364295 | 131730 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 700 | 12 | 10 | 7 | 0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||
| CHEMBL3959529 | 219270 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 11176403 | 8874 | 1 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| 2900 | 8874 | 1 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| CHEMBL452864 | 8874 | 1 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| CHEMBL3924163 | 219236 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112537 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112537 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112537 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL426169 | 220123 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | None | None | None | CN1C(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1Cc1ccc2ccccc2c1 | 10.1021/jm0607350 | ||||
| 477101 | 19692 | 2 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 638 | 4 | 4 | 8 | 4.7 | Clc1cc2nc(c1)CNCCCN(Cc1ccc(CN3CCCNCc4cc(Cl)cc(n4)CNCCC3)cc1)CCCNC2 | 10.1021/jm990211i | ||
| CHEMBL1189096 | 19692 | 2 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 638 | 4 | 4 | 8 | 4.7 | Clc1cc2nc(c1)CNCCCN(Cc1ccc(CN3CCCNCc4cc(Cl)cc(n4)CNCCC3)cc1)CCCNC2 | 10.1021/jm990211i | ||
| CHEMBL538038 | 19692 | 2 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 638 | 4 | 4 | 8 | 4.7 | Clc1cc2nc(c1)CNCCCN(Cc1ccc(CN3CCCNCc4cc(Cl)cc(n4)CNCCC3)cc1)CCCNC2 | 10.1021/jm990211i | ||
| 11176403 | 8874 | 1 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| 2900 | 8874 | 1 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| CHEMBL452864 | 8874 | 1 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 378 | 4 | 1 | 5 | 4.6 | C1CCC(CC1)N/C(=N/C1CCCCC1)/SCc1csc2=NCCn12 | 10.1021/jm801065q | ||
| 138501448 | 189768 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 381 | 5 | 1 | 7 | 2.2 | CNc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4793397 | 189768 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 381 | 5 | 1 | 7 | 2.2 | CNc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL3903301 | 219220 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL3952526 | 219262 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.6b00695 | ||||
| CHEMBL3981298 | 219296 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.6b00695 | ||||
| 56648410 | 77390 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1599 | 31 | 20 | 18 | -2.2 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)CCC(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 91930558 | 77390 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1599 | 31 | 20 | 18 | -2.2 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)CCC(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949885 | 77390 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1599 | 31 | 20 | 18 | -2.2 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)CCC(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949731 | 215880 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | None | None | None | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCN | 10.1021/jm2009716 | ||||
| 4410 | 9911 | 106 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.6b00695 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.6b00695 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.6b00695 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.6b00695 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.6b00695 | ||
| 137636951 | 162988 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1019 | 18 | 14 | 12 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4064373 | 162988 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1019 | 18 | 14 | 12 | -0.2 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| 131801411 | 165096 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1009 | 18 | 15 | 13 | -1.4 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4089168 | 165096 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1009 | 18 | 15 | 13 | -1.4 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL3360195 | 218351 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm401823z | ||||
| 72545830 | 110611 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 4.5 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1ccccn1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091688 | 110611 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 4.5 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1ccccn1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 72546062 | 110613 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 4.5 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1ccncc1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091690 | 110613 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 4.5 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1ccncc1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 56649213 | 77377 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 743 | 12 | 9 | 8 | -0.1 | CC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949732 | 77377 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 743 | 12 | 9 | 8 | -0.1 | CC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 10485171 | 128157 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 743 | 12 | 12 | 8 | -0.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CCNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/acs.jmedchem.5b00216 | ||
| CHEMBL3581263 | 128157 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 743 | 12 | 12 | 8 | -0.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CCNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/acs.jmedchem.5b00216 | ||
| CHEMBL5281510 | 200892 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 2845 | 99 | 46 | 38 | -12.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N(CCCCCC(=O)O)[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114797 | ||
| 137649245 | 163947 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 512 | 15 | 5 | 10 | 3.3 | CC(C)c1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4075454 | 163947 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 512 | 15 | 5 | 10 | 3.3 | CC(C)c1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL366033 | 218826 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||||
| 155544593 | 180115 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 1165 | 35 | 18 | 16 | -5.1 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4526799 | 180115 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 1165 | 35 | 18 | 16 | -5.1 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(N)=O | 10.1016/j.ejmech.2019.03.056 | ||
| 71720811 | 94982 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 481 | 11 | 7 | 3 | 5.3 | N=C(NCCCCNCCCNC(=N)Nc1ccc2ccccc2c1)Nc1ccc2ccccc2c1 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2347627 | 94982 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 481 | 11 | 7 | 3 | 5.3 | N=C(NCCCCNCCCNC(=N)Nc1ccc2ccccc2c1)Nc1ccc2ccccc2c1 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2012528 | 215900 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(N)=O)C(=O)C1)C(=O)O | 10.1021/ml200084n | ||||
| 51346842 | 65210 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 338 | 7 | 1 | 4 | 3.7 | Cc1cnc(CN(CCCCN)[C@H]2CCCc3cccnc32)c(C)c1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682995 | 65210 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 338 | 7 | 1 | 4 | 3.7 | Cc1cnc(CN(CCCCN)[C@H]2CCCc3cccnc32)c(C)c1 | 10.1016/j.bmcl.2011.01.021 | ||
| 138501606 | 188575 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.7 | Cc1nc(CN2CCCCC2c2ccccn2)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4777987 | 188575 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.7 | Cc1nc(CN2CCCCC2c2ccccn2)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL3901189 | 219217 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | C[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.6b00695 | ||||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.7b01062 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.7b01062 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.7b01062 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL1949730 | 215879 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=N)N | 10.1021/jm2016914 | ||||
| CHEMBL191687 | 215860 | 1 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | C[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm050009h | ||||
| CHEMBL2180081 | 215860 | 1 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | C[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/jm050009h | ||||
| CHEMBL374108 | 218973 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm0607350 | ||||
| 145975500 | 170294 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 366 | 5 | 0 | 6 | 2.7 | CN(C)C1CCN(N(Cc2ccncn2)C2CCCc3cccnc32)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4202510 | 170294 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 366 | 5 | 0 | 6 | 2.7 | CN(C)C1CCN(N(Cc2ccncn2)C2CCCc3cccnc32)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 10146 | 8051 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 10.1016/j.ejmech.2018.10.060 | ||
| 137321154 | 8051 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4596188 | 8051 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155518071 | 177029 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 362 | 6 | 1 | 2 | 5.0 | Clc1ccc(CNCC2CCN(Cc3ccccc3Cl)CC2)cc1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4445831 | 177029 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 362 | 6 | 1 | 2 | 5.0 | Clc1ccc(CNCC2CCN(Cc3ccccc3Cl)CC2)cc1 | 10.1016/j.ejmech.2018.10.060 | ||
| 25147749 | 8875 | 18 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| 2899 | 8875 | 18 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| 155534825 | 178780 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 2794 | 103 | 41 | 41 | -11.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](C)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4471355 | 178780 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 2794 | 103 | 41 | 41 | -11.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](C)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)NCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL3974242 | 219284 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL3923282 | 219234 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.6b00695 | ||||
| 145969178 | 171607 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 368 | 7 | 1 | 7 | 1.6 | c1cnc2c(c1)CCCC2N(Cc1ccncn1)NCCN1CCOCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4218715 | 171607 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 368 | 7 | 1 | 7 | 1.6 | c1cnc2c(c1)CCCC2N(Cc1ccncn1)NCCN1CCOCC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL373637 | 218966 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCCN2C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCNC(=N)N)NC1=O | 10.1021/jm0607350 | ||||
| 4410 | 9911 | 106 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2016.08.062 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2016.08.062 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2016.08.062 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1016/j.bmc.2016.08.062 | ||
| 138501638 | 186553 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 396 | 7 | 1 | 7 | 2.4 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(NCCN2CCOCC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4744555 | 186553 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 396 | 7 | 1 | 7 | 2.4 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(NCCN2CCOCC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 57345320 | 10604 | 9 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| 9882 | 10604 | 9 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL3091687 | 10604 | 9 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| 56647829 | 77378 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 814 | 16 | 10 | 9 | -0.4 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCC(N)=O | 10.1021/jm2009716 | ||
| CHEMBL1949733 | 77378 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 814 | 16 | 10 | 9 | -0.4 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CCCC(N)=O | 10.1021/jm2009716 | ||
| 460326 | 120895 | 1 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | c1cc(CN2CCCNCCNCCNCCC2)ccc1CN1CCCNCCNCCNCCC1 | 10.1021/jm990211i | ||
| CHEMBL332798 | 120895 | 1 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | c1cc(CN2CCCNCCNCCNCCC2)ccc1CN1CCCNCCNCCNCCC1 | 10.1021/jm990211i | ||
| CHEMBL543895 | 120895 | 1 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | c1cc(CN2CCCNCCNCCNCCC2)ccc1CN1CCCNCCNCCNCCC1 | 10.1021/jm990211i | ||
| CHEMBL5282178 | 200927 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 490 | 15 | 4 | 4 | 6.2 | c1cc(-c2ccc(CNCCCNC3CCCCC3)cc2)ccc1CNCCCNC1CCCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| CHEMBL5283630 | 201001 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 443 | 15 | 5 | 5 | 4.5 | CNc1cc(CNCCCNC2CCCCC2)cc(CNCCCNC2CCCCC2)c1 | 10.1016/j.ejmech.2020.112410 | ||
| CHEMBL3931947 | 219242 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 66558669 | 82237 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=N)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/ml200047e | ||
| CHEMBL2042233 | 82237 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=N)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/ml200047e | ||
| CHEMBL5277914 | 200736 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 429 | 14 | 5 | 5 | 4.1 | Nc1cc(CNCCCNC2CCCCC2)ccc1CNCCCNC1CCCCC1 | 10.1016/j.ejmech.2020.112410 | ||
| CHEMBL3978794 | 219290 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 11411355 | 76104 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 687 | 11 | 11 | 9 | -1.7 | N=C(N)NCCC[C@H]1NC(=O)[C@H](NC(=O)CCNC(=N)N)CSSC[C@@H](C(N)=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||
| CHEMBL192913 | 76104 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 687 | 11 | 11 | 9 | -1.7 | N=C(N)NCCC[C@H]1NC(=O)[C@H](NC(=O)CCNC(=N)N)CSSC[C@@H](C(N)=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||
| CHEMBL409991 | 166104 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 1993 | 47 | 30 | 26 | -5.9 | C[C@H]1/C=C\[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)C(CCCNC(N)=O)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1016/s0960-894x(02)00041-0 | ||
| 162669065 | 189517 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 750 | 19 | 5 | 11 | 2.5 | CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)NC[C@H]1CC[C@H](/N=C(\NC2CCCCC2)SCC2=CSC3=NC(C)(C)CN23)CC1 | 10.1021/acsmedchemlett.0c00444 | ||
| CHEMBL4789939 | 189517 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 750 | 19 | 5 | 11 | 2.5 | CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)NC[C@H]1CC[C@H](/N=C(\NC2CCCCC2)SCC2=CSC3=NC(C)(C)CN23)CC1 | 10.1021/acsmedchemlett.0c00444 | ||
| CHEMBL5278283 | 200752 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 13 | 4 | 4 | 4.1 | O=C(NCCCNC1CCCCC1)c1ccc(CNCCCNC2CCCCC2)cc1 | 10.1016/j.ejmech.2020.112410 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm990211i | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm990211i | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm990211i | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm990211i | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm990211i | ||
| 72535437 | 151793 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 456 | 10 | 2 | 6 | 4.6 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN)c12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3911032 | 151793 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 456 | 10 | 2 | 6 | 4.6 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN)c12)C1CCCc2cccnc21 | nan | ||
| 72535445 | 159750 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 512 | 10 | 1 | 7 | 4.5 | NCCCCN(Cc1nccc2c3ccccc3n(CCN3CCOCC3)c12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3975192 | 159750 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 512 | 10 | 1 | 7 | 4.5 | NCCCCN(Cc1nccc2c3ccccc3n(CCN3CCOCC3)c12)C1CCCc2cccnc21 | nan | ||
| 155560382 | 181866 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 577 | 9 | 3 | 7 | 4.7 | c1ccc(CN(Cc2ccccn2)Cc2ccccc2-c2cccc(CN3CCCNCCNCCCNCC3)c2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| CHEMBL4568686 | 181866 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 577 | 9 | 3 | 7 | 4.7 | c1ccc(CN(Cc2ccccn2)Cc2ccccc2-c2cccc(CN3CCCNCCNCCCNCC3)c2)nc1 | 10.1016/j.bmc.2019.02.013 | ||
| 138501794 | 187223 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 392 | 5 | 0 | 6 | 3.0 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C3CC3)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4752542 | 187223 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 392 | 5 | 0 | 6 | 3.0 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C3CC3)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 72546061 | 110612 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 4.5 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1cccnc1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091689 | 110612 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 4.5 | NCCCCN(C[C@H]1Cc2ccccc2CN1Cc1cccnc1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 137654477 | 165527 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 985 | 18 | 15 | 13 | -1.6 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| CHEMBL4093767 | 165527 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 985 | 18 | 15 | 13 | -1.6 | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H]1CSSC(C)(C)[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1021/acs.jmedchem.7b01062 | ||
| 137643115 | 165189 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 598 | 20 | 5 | 11 | 3.8 | Cc1cc(NC2CCN(CCCCCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4090175 | 165189 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 598 | 20 | 5 | 11 | 3.8 | Cc1cc(NC2CCN(CCCCCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 137662117 | 166098 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 504 | 14 | 5 | 10 | 2.8 | Clc1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4099856 | 166098 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 504 | 14 | 5 | 10 | 2.8 | Clc1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 118965366 | 165960 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 613 | 18 | 6 | 12 | 1.9 | Cc1cc(NC2CCN(C(=O)CC[C@H](N)C(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4098404 | 165960 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 613 | 18 | 6 | 12 | 1.9 | Cc1cc(NC2CCN(C(=O)CC[C@H](N)C(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 25147749 | 8875 | 18 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| 2899 | 8875 | 18 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| 137633110 | 163363 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 627 | 20 | 6 | 12 | 2.0 | CCc1cc(NC2CCN(C(=O)CCNCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4068647 | 163363 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 627 | 20 | 6 | 12 | 2.0 | CCc1cc(NC2CCN(C(=O)CCNCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 137658485 | 166351 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 537 | 16 | 4 | 11 | 3.1 | Cc1cc(NC2CCN(CCC#N)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4102780 | 166351 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 537 | 16 | 4 | 11 | 3.1 | Cc1cc(NC2CCN(CCC#N)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 137643051 | 165152 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 627 | 20 | 6 | 12 | 2.1 | Cc1cc(NC2CCN(C(=O)CCNCCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4089763 | 165152 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 627 | 20 | 6 | 12 | 2.1 | Cc1cc(NC2CCN(C(=O)CCNCCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1128/aac.01727-08 | ||
| CHEMBL3970509 | 219281 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL409991 | 166104 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 1993 | 47 | 30 | 26 | -5.9 | C[C@H]1/C=C\[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)CSSC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)C(CCCNC(N)=O)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1016/s0960-894x(02)00041-0 | ||
| 155534351 | 178712 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 2398 | 91 | 30 | 37 | -9.1 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)NCCOCCOCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4470243 | 178712 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 2398 | 91 | 30 | 37 | -9.1 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)NCCOCCOCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm300682j | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm300682j | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm300682j | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm300682j | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1021/jm300682j | ||
| 25147749 | 8875 | 18 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1039/c9md00433e | ||
| 2899 | 8875 | 18 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1039/c9md00433e | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1039/c9md00433e | ||
| 162670980 | 189630 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 778 | 21 | 5 | 11 | 3.3 | CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NC[C@H]1CC[C@H](/N=C(/NC2CCCCC2)SCC2=CSC3=NC(C)(C)CN23)CC1 | 10.1039/c9md00433e | ||
| CHEMBL4791514 | 189630 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 778 | 21 | 5 | 11 | 3.3 | CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NC[C@H]1CC[C@H](/N=C(/NC2CCCCC2)SCC2=CSC3=NC(C)(C)CN23)CC1 | 10.1039/c9md00433e | ||
| 155517509 | 176962 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 1444 | 51 | 26 | 23 | -10.5 | C[C@@H](O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)CCCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4444790 | 176962 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 1444 | 51 | 26 | 23 | -10.5 | C[C@@H](O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)CCCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O | 10.1016/j.ejmech.2019.03.056 | ||
| 155511299 | 176326 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 2806 | 107 | 36 | 43 | -9.9 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCOCCOCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| CHEMBL4435545 | 176326 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 2806 | 107 | 36 | 43 | -9.9 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCOCCOCCOCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCOCCOCCOCCOCCOCCNC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CO)NC(=O)[C@@H](C)NC(=O)CNC(=O)[C@H](N)CC(C)C)C(N)=O | 10.1016/j.bmc.2016.08.062 | ||
| 11625279 | 14882 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 4 | 0 | 5 | 4.2 | CN1CCC(n2c(CN(C)C3CCCc4cccnc43)nc3ccccc32)CC1 | 10.1016/j.bmcl.2010.02.053 | ||
| CHEMBL1091591 | 14882 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 4 | 0 | 5 | 4.2 | CN1CCC(n2c(CN(C)C3CCCc4cccnc43)nc3ccccc32)CC1 | 10.1016/j.bmcl.2010.02.053 | ||
| 138501446 | 190125 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 396 | 6 | 0 | 7 | 2.5 | CCOc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4797590 | 190125 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 396 | 6 | 0 | 7 | 2.5 | CCOc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL3940962 | 219249 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 138501464 | 190264 | 3 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.6 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| CHEMBL4799439 | 190264 | 3 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.6 | Cc1nc(CN2CCC[C@H]2c2ncccc2C)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2020.112537 | ||
| 138501723 | 190095 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 425 | 7 | 1 | 8 | 1.6 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)nc(N(C)CCO)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4797285 | 190095 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 425 | 7 | 1 | 8 | 1.6 | CN1CCN(c2cc(CN(C)C3CCCc4cccnc43)nc(N(C)CCO)n2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| 155539331 | 179619 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 328 | 6 | 1 | 2 | 4.3 | Clc1ccccc1CN1CCC(CNCc2ccccc2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4514484 | 179619 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 328 | 6 | 1 | 2 | 4.3 | Clc1ccccc1CN1CCC(CNCc2ccccc2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155514823 | 176689 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 352 | 8 | 1 | 3 | 4.3 | CCc1cccc(CNCC2CCN(Cc3ccccc3OC)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4440964 | 176689 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 352 | 8 | 1 | 3 | 4.3 | CCc1cccc(CNCC2CCN(Cc3ccccc3OC)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155550210 | 180651 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 338 | 7 | 1 | 3 | 4.0 | COc1ccccc1CN1CCC(CNCc2cccc(C)c2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4539571 | 180651 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 338 | 7 | 1 | 3 | 4.0 | COc1ccccc1CN1CCC(CNCc2cccc(C)c2)CC1 | 10.1016/j.ejmech.2018.10.060 | ||
| 155549012 | 180999 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 376 | 6 | 1 | 2 | 5.3 | Cc1cccc(CNCC2CCN(Cc3cccc(Cl)c3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| CHEMBL4548557 | 180999 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 376 | 6 | 1 | 2 | 5.3 | Cc1cccc(CNCC2CCN(Cc3cccc(Cl)c3Cl)CC2)c1 | 10.1016/j.ejmech.2018.10.060 | ||
| 132072454 | 186503 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 558 | 6 | 2 | 8 | 4.7 | COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 | 10.1016/j.bmc.2020.115546 | ||
| CHEMBL4744046 | 186503 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 558 | 6 | 2 | 8 | 4.7 | COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 | 10.1016/j.bmc.2020.115546 | ||
| 59826001 | 168944 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 344 | 6 | 0 | 3 | 3.1 | CN(Cc1ccccc1)S(=O)(=O)c1ccc(CN2CCCC2)cc1 | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4162225 | 168944 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 344 | 6 | 0 | 3 | 3.1 | CN(Cc1ccccc1)S(=O)(=O)c1ccc(CN2CCCC2)cc1 | 10.1016/j.ejmech.2017.08.027 | ||
| 56648314 | 77389 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 1585 | 30 | 20 | 18 | -2.6 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)CC(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 91930557 | 77389 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 1585 | 30 | 20 | 18 | -2.6 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)CC(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949884 | 77389 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 1585 | 30 | 20 | 18 | -2.6 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)CNC(=O)CC(=O)NCC(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 25147749 | 8875 | 18 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/jm801065q | ||
| 2899 | 8875 | 18 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/jm801065q | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/jm801065q | ||
| CHEMBL2180077 | 220456 | 1 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmc.2014.07.004 | ||||
| CHEMBL436097 | 220456 | 1 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1016/j.bmc.2014.07.004 | ||||
| CHEMBL219339 | 216190 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCNC(=N)N)NC1=O | 10.1021/jm0607350 | ||||
| 126842508 | 150535 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 583 | 10 | 1 | 7 | 5.0 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)I=O)c12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3900826 | 150535 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 583 | 10 | 1 | 7 | 5.0 | NCCCCN(Cc1nccc2c3ccccc3n(CC(=O)I=O)c12)C1CCCc2cccnc21 | nan | ||
| 138501643 | 186353 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 380 | 4 | 0 | 6 | 2.8 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C)[C@H](C)C2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4741926 | 186353 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 380 | 4 | 0 | 6 | 2.8 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C)[C@H](C)C2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 138501645 | 188178 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 394 | 4 | 0 | 6 | 3.2 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2C[C@H](C)N(C)[C@H](C)C2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4763585 | 188178 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 394 | 4 | 0 | 6 | 3.2 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2C[C@H](C)N(C)[C@H](C)C2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 72535503 | 154847 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 4.5 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN3CCNCC3)c12)C1CCCc2cccnc21 | nan | ||
| CHEMBL3934822 | 154847 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 4.5 | NCCCCN(Cc1nccc2c3ccccc3n(CCCN3CCNCC3)c12)C1CCCc2cccnc21 | nan | ||
| 5275843 | 220457 | 31 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||||
| CHEMBL2180076 | 220457 | 31 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||||
| CHEMBL436283 | 220457 | 31 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||||
| 138501621 | 187137 | 3 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.4 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4751485 | 187137 | 3 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 366 | 4 | 0 | 6 | 2.4 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 25178353 | 197677 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 434 | 4 | 1 | 5 | 6.1 | CC1(C)CN2C(CS/C(=N\C3CCCCCC3)NC3CCCCCC3)=CSC2=N1 | 10.1021/jm801065q | ||
| CHEMBL518501 | 197677 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 434 | 4 | 1 | 5 | 6.1 | CC1(C)CN2C(CS/C(=N\C3CCCCCC3)NC3CCCCCC3)=CSC2=N1 | 10.1021/jm801065q | ||
| 51031036 | 169448 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 358 | 6 | 0 | 3 | 3.5 | CN(Cc1ccccc1)S(=O)(=O)c1ccc(CN2CCCCC2)cc1 | 10.1016/j.ejmech.2017.08.027 | ||
| CHEMBL4170138 | 169448 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 358 | 6 | 0 | 3 | 3.5 | CN(Cc1ccccc1)S(=O)(=O)c1ccc(CN2CCCCC2)cc1 | 10.1016/j.ejmech.2017.08.027 | ||
| 72546064 | 110615 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 491 | 9 | 1 | 6 | 2.8 | NCCCCN(C[C@H]1Cc2ccccc2CN1CC(=O)N1CCOCC1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| CHEMBL3091692 | 110615 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 491 | 9 | 1 | 6 | 2.8 | NCCCCN(C[C@H]1Cc2ccccc2CN1CC(=O)N1CCOCC1)[C@H]1CCCc2cccnc21 | 10.1021/ml400183q | ||
| 25178144 | 183637 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 430 | 4 | 1 | 5 | 5.1 | C1=C(CS/C(=N\C2CCCCC2)NC2C3CC4CC(C3)CC2C4)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL461359 | 183637 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 430 | 4 | 1 | 5 | 5.1 | C1=C(CS/C(=N\C2CCCCC2)NC2C3CC4CC(C3)CC2C4)N2CCN=C2S1 | 10.1021/jm801065q | ||
| CHEMBL5285076 | 201057 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 429 | 14 | 5 | 5 | 4.1 | Nc1cc(CNCCCNC2CCCCC2)cc(CNCCCNC2CCCCC2)c1 | 10.1016/j.ejmech.2020.112410 | ||
| 137648362 | 164522 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 556 | 17 | 5 | 11 | 2.6 | Cc1cc(NC2CCN(CCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4082328 | 164522 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 556 | 17 | 5 | 11 | 2.6 | Cc1cc(NC2CCN(CCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 137658540 | 166471 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 613 | 19 | 6 | 12 | 1.7 | Cc1cc(NC2CCN(C(=O)CNCCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4104222 | 166471 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 613 | 19 | 6 | 12 | 1.7 | Cc1cc(NC2CCN(C(=O)CNCCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL3976727 | 219287 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL3982241 | 219299 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 5275843 | 220457 | 31 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm2016914 | ||||
| CHEMBL2180076 | 220457 | 31 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm2016914 | ||||
| CHEMBL436283 | 220457 | 31 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm2016914 | ||||
| 25178567 | 183636 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 380 | 8 | 1 | 5 | 4.8 | CCCCCCN/C(=N/C1CCCCC1)SCC1=CSC2=NCCN12 | 10.1021/jm801065q | ||
| CHEMBL461358 | 183636 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 380 | 8 | 1 | 5 | 4.8 | CCCCCCN/C(=N/C1CCCCC1)SCC1=CSC2=NCCN12 | 10.1021/jm801065q | ||
| 137638711 | 163752 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 538 | 14 | 5 | 10 | 3.2 | FC(F)(F)c1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4072978 | 163752 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 538 | 14 | 5 | 10 | 3.2 | FC(F)(F)c1cc(NC2CCNCC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL3628613 | 218667 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | [N-]=[N+]=NCCCCCC(=O)NCCCC(=O)N[C@@H](CCCCNC(=O)CSC[C@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(=O)CS[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O)C(N)=O | 10.1016/j.bmc.2015.09.040 | ||||
| CHEMBL5273020 | 200524 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 2845 | 99 | 46 | 38 | -12.7 | CC(C)C[C@@H](N)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N(CCCCCC(=O)O)[C@H](CCCCN)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)NCC(=O)N1CCC[C@@H]1C(=O)NCC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](C)C(=O)N[C@H](Cc1ccccc1)C(N)=O | 10.1016/j.ejmech.2022.114797 | ||
| 145975799 | 170393 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)[C@H]3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4203703 | 170393 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)[C@H]3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2019.111914 | ||
| 145975799 | 170393 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)[C@H]3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| CHEMBL4203703 | 170393 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 352 | 4 | 0 | 6 | 2.1 | CN1CCN(c2cc(CN(C)[C@H]3CCCc4cccnc43)ncn2)CC1 | 10.1016/j.ejmech.2018.02.042 | ||
| 137649869 | 164308 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 627 | 20 | 6 | 12 | 2.1 | Cc1cc(NC2CCN(C(=O)CCCNCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4079981 | 164308 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 627 | 20 | 6 | 12 | 2.1 | Cc1cc(NC2CCN(C(=O)CCCNCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 53320547 | 63677 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 5 | 2 | 5 | 4.6 | NCc1cscc1N(Cc1nc2ccccc2[nH]1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| CHEMBL1644081 | 63677 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 389 | 5 | 2 | 5 | 4.6 | NCc1cscc1N(Cc1nc2ccccc2[nH]1)[C@H]1CCCc2cccnc21 | 10.1016/j.bmcl.2010.11.023 | ||
| 162672979 | 189787 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 404 | 5 | 2 | 5 | 5.2 | CCOC(=O)c1c(NC(=S)Nc2cccc(OC)c2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL4793669 | 189787 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 404 | 5 | 2 | 5 | 5.2 | CCOC(=O)c1c(NC(=S)Nc2cccc(OC)c2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| 133081963 | 7885 | 0 | None | - | 0 | Mouse | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 446 | 8 | 2 | 5 | 3.8 | O1CCC(CC1)NC/C=C/CN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acs.jmedchem.7b01420 | ||
| 9883 | 7885 | 0 | None | - | 0 | Mouse | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 446 | 8 | 2 | 5 | 3.8 | O1CCC(CC1)NC/C=C/CN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acs.jmedchem.7b01420 | ||
| CHEMBL4075205 | 7885 | 0 | None | - | 0 | Mouse | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 446 | 8 | 2 | 5 | 3.8 | O1CCC(CC1)NC/C=C/CN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acs.jmedchem.7b01420 | ||
| 70965023 | 151274 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 567 | 10 | 1 | 8 | 4.1 | c1cnc2c(c1)CCCC2N(CCCN1CCNCC1)Cc1nccc2c3ccccc3n(CCN3CCOCC3)c12 | nan | ||
| CHEMBL3906863 | 151274 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 567 | 10 | 1 | 8 | 4.1 | c1cnc2c(c1)CCCC2N(CCCN1CCNCC1)Cc1nccc2c3ccccc3n(CCN3CCOCC3)c12 | nan | ||
| 66545960 | 82231 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=N)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/ml200047e | ||
| CHEMBL2042117 | 82231 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 728 | 12 | 13 | 8 | -0.6 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=N)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/ml200047e | ||
| CHEMBL2012523 | 215895 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)C1)C(=O)O | 10.1021/ml200084n | ||||
| 89667385 | 150024 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 9 | 1 | 7 | 4.8 | C[C@H]1CN(C(=O)Cn2c3ccccc3c3ccnc(CN(CCCCN)C4CCCc5cccnc54)c32)C[C@@H](C)O1 | nan | ||
| CHEMBL3896614 | 150024 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 9 | 1 | 7 | 4.8 | C[C@H]1CN(C(=O)Cn2c3ccccc3c3ccnc(CN(CCCCN)C4CCCc5cccnc54)c32)C[C@@H](C)O1 | nan | ||
| CHEMBL372874 | 218952 | 1 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2C[C@H](N=C(N)N)CN2C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm050009h | ||||
| 134155140 | 157913 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 3268 | 83 | 51 | 43 | -7.5 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cc2cccc3ccc4cccc1c4c32)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| CHEMBL3959440 | 157913 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 3268 | 83 | 51 | 43 | -7.5 | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cc2cccc3ccc4cccc1c4c32)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||
| 57345320 | 10604 | 9 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| 9882 | 10604 | 9 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL3091687 | 10604 | 9 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| 137648113 | 164483 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 649 | 19 | 7 | 12 | 1.8 | Cc1cc(NC2CCN(C(=O)CCNCP(=O)(O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4081892 | 164483 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 649 | 19 | 7 | 12 | 1.8 | Cc1cc(NC2CCN(C(=O)CCNCP(=O)(O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 155517509 | 176962 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 1444 | 51 | 26 | 23 | -10.5 | C[C@@H](O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)CCCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL4444790 | 176962 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 1444 | 51 | 26 | 23 | -10.5 | C[C@@H](O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)CCCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O | 10.1016/j.ejmech.2019.03.056 | ||
| CHEMBL376811 | 219035 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | C[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O | 10.1021/jm0607350 | ||||
| 118965426 | 163401 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 584 | 19 | 5 | 11 | 3.4 | Cc1cc(NC2CCN(CCCCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4069110 | 163401 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 584 | 19 | 5 | 11 | 3.4 | Cc1cc(NC2CCN(CCCCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 71719569 | 94988 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 706 | 16 | 9 | 4 | 8.2 | N=C(NCCCNCCCCN(CCCNC(=N)Nc1ccc2ccccc2c1)C(=N)Nc1ccc2ccccc2c1)Nc1ccc2ccccc2c1 | 10.1016/j.bmcl.2013.01.107 | ||
| CHEMBL2347633 | 94988 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 706 | 16 | 9 | 4 | 8.2 | N=C(NCCCNCCCCN(CCCNC(=N)Nc1ccc2ccccc2c1)C(=N)Nc1ccc2ccccc2c1)Nc1ccc2ccccc2c1 | 10.1016/j.bmcl.2013.01.107 | ||
| 138501454 | 188172 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 409 | 6 | 1 | 7 | 3.0 | CC(C)Nc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4763507 | 188172 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 409 | 6 | 1 | 7 | 3.0 | CC(C)Nc1nc(CN(C)C2CCCc3cccnc32)cc(N2CCN(C)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 162668274 | 189330 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 388 | 4 | 2 | 4 | 5.6 | CC(C)OC(=O)c1c(NC(=S)Nc2ccccc2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL4787532 | 189330 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 388 | 4 | 2 | 4 | 5.6 | CC(C)OC(=O)c1c(NC(=S)Nc2ccccc2)sc2c1C(C)CCC2 | 10.1016/j.ejmech.2020.112387 | ||
| CHEMBL3949729 | 219260 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| CHEMBL3954553 | 219267 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCCCC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1)C(=O)O | 10.1021/acs.jmedchem.6b00566 | ||||
| 142549051 | 186972 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 449 | 5 | 0 | 7 | 2.9 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCC(N3CCN(C)CC3)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| CHEMBL4749488 | 186972 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 449 | 5 | 0 | 7 | 2.9 | Cc1nc(CN(C)[C@H]2CCCc3cccnc32)cc(N2CCC(N3CCN(C)CC3)CC2)n1 | 10.1016/j.ejmech.2019.111914 | ||
| 51346844 | 65209 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 324 | 7 | 1 | 4 | 3.4 | Cc1cccc(CN(CCCCN)[C@H]2CCCc3cccnc32)n1 | 10.1016/j.bmcl.2011.01.021 | ||
| CHEMBL1682994 | 65209 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 324 | 7 | 1 | 4 | 3.4 | Cc1cccc(CN(CCCCN)[C@H]2CCCc3cccnc32)n1 | 10.1016/j.bmcl.2011.01.021 | ||
| 25147749 | 8875 | 18 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| 2899 | 8875 | 18 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL460491 | 8875 | 18 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 406 | 4 | 1 | 5 | 5.4 | CC1(C)N=c2n(C1)c(cs2)CS/C(=N\C1CCCCC1)/NC1CCCCC1 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL365952 | 218823 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | NCCCC[C@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCN=C(N)N)NC1=O | 10.1021/jm050009h | ||||
| 118965398 | 164264 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 627 | 19 | 5 | 12 | 1.8 | Cc1cc(N(C)C2CCN(C(=O)CCNCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| CHEMBL4079460 | 164264 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 627 | 19 | 5 | 12 | 1.8 | Cc1cc(N(C)C2CCN(C(=O)CCNCC(=O)O)CC2)nc(NCc2cn(CCCNCCCNC3CCCCC3)nn2)n1 | 10.1021/acs.jmedchem.7b01322 | ||
| 57345320 | 10604 | 9 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| 9882 | 10604 | 9 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| CHEMBL3091687 | 10604 | 9 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.2 | NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2 | 10.1021/acsmedchemlett.8b00441 | ||
| 56647929 | 77392 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 1999 | 42 | 23 | 25 | -3.2 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)C[C@H](NC(=O)CCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| 91930560 | 77392 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 1999 | 42 | 23 | 25 | -3.2 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)C[C@H](NC(=O)CCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL1949887 | 77392 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 1999 | 42 | 23 | 25 | -3.2 | CN1C(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]1CCCNC(=O)C[C@H](NC(=O)CCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)NCCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)NCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1021/jm2009716 | ||
| CHEMBL436536 | 220461 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | None | None | None | CN1C(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCNC(=N)N | 10.1021/jm0607350 | ||||
| 168286390 | 198522 | 0 | None | - | 1 | Human | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 1024 | 24 | 10 | 12 | 7.0 | N/C(=N\C(=O)CCCCCNC(=S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)NCCC[C@H](NCc1ccccn1)C(=O)NCc1ccc(CNCCCNC2CCCCC2)cc1 | 10.1016/j.ejmech.2022.114150 | ||
| CHEMBL5197361 | 198522 | 0 | None | - | 1 | Human | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 1024 | 24 | 10 | 12 | 7.0 | N/C(=N\C(=O)CCCCCNC(=S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)NCCC[C@H](NCc1ccccn1)C(=O)NCc1ccc(CNCCCNC2CCCCC2)cc1 | 10.1016/j.ejmech.2022.114150 | ||
| 11950261 | 23429 | 9 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL1242211 | 23429 | 9 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL2062277 | 23429 | 9 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 479 | 17 | 1 | 6 | 4.7 | CCCN(CCC)CCCCN(C)Cc1ccc(CN(Cc2ncc[nH]2)Cc2nccn2C)cc1 | 10.1021/acs.jmedchem.6b01309 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1021/acs.jmedchem.6b01309 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 134694953 | 164663 | 15 | None | -851 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 522 | 7 | 1 | 7 | 2.5 | CCc1ccn2ccnc2c1N1CCCN([C@@H](CC(N)=O)C2CCN(C(=O)[C@H]3C[C@@H]4CC[C@H]3O4)CC2)CC1 | 10.1021/acs.jmedchem.8b00190 | ||
| CHEMBL4084050 | 164663 | 15 | None | -851 | 3 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 522 | 7 | 1 | 7 | 2.5 | CCc1ccn2ccnc2c1N1CCCN([C@@H](CC(N)=O)C2CCN(C(=O)[C@H]3C[C@@H]4CC[C@H]3O4)CC2)CC1 | 10.1021/acs.jmedchem.8b00190 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 64964 | 23681 | 112 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 200 | 0 | 4 | 4 | -0.9 | C1CNCCNCCCNCCNC1 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL125150 | 23681 | 112 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 200 | 0 | 4 | 4 | -0.9 | C1CNCCNCCCNCCNC1 | 10.1021/acs.jmedchem.6b01309 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 460344 | 22448 | 11 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL122226 | 22448 | 11 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 304 | 2 | 3 | 4 | 1.4 | Cc1ccc(CN2CCCNCCNCCCNCC2)cc1 | 10.1021/acs.jmedchem.6b01309 | ||
| 483570 | 188871 | 1 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL478168 | 188871 | 1 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 409 | 6 | 4 | 5 | 2.3 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)cc1 | 10.1021/acs.jmedchem.6b01309 | ||
| 453871 | 107138 | 6 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 440 | 4 | 6 | 8 | -0.9 | C1CNCCNCCCN(CCCN2CCCNCCNCCCNCC2)CCNC1 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL28967 | 107138 | 6 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 440 | 4 | 6 | 8 | -0.9 | C1CNCCNCCCN(CCCN2CCCNCCNCCCNCC2)CCNC1 | 10.1021/acs.jmedchem.6b01309 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 11256587 | 9240 | 59 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/acs.jmedchem.6b01309 | ||
| 8580 | 9240 | 59 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL518924 | 9240 | 59 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/acs.jmedchem.6b01309 | ||
| DB05501 | 9240 | 59 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 10.1021/acs.jmedchem.6b01309 | ||
| 454260 | 25209 | 1 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 482 | 7 | 6 | 8 | 0.3 | C(CCCN1CCCNCCNCCCNCC1)CCN1CCCNCCNCCCNCC1 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL127188 | 25209 | 1 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 482 | 7 | 6 | 8 | 0.3 | C(CCCN1CCCNCCNCCCNCC1)CCN1CCCNCCNCCCNCC1 | 10.1021/acs.jmedchem.6b01309 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 5708903 | 24843 | 13 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 288 | 4 | 1 | 3 | 4.0 | COc1cc(/C=C/C(=O)c2ccc(Cl)cc2)ccc1O | 10.1021/ml200017d | ||
| CHEMBL126657 | 24843 | 13 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 288 | 4 | 1 | 3 | 4.0 | COc1cc(/C=C/C(=O)c2ccc(Cl)cc2)ccc1O | 10.1021/ml200017d | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL5284797 | 201043 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 440 | 4 | 7 | 8 | -0.8 | C1CNCCNCCCN(CCC[C@H]2CNCCCNCCNCCCN2)CCNC1 | 10.1021/acs.jmedchem.6b01309 | ||
| 465968 | 95975 | 9 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 551 | 13 | 6 | 5 | 3.8 | C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)c1ccc(CNCc2ccccn2)cc1)c1cccc2ccccc12 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL2367715 | 95975 | 9 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 551 | 13 | 6 | 5 | 3.8 | C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)c1ccc(CNCc2ccccn2)cc1)c1cccc2ccccc12 | 10.1021/acs.jmedchem.6b01309 | ||
| 461237 | 105526 | 1 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 503 | 4 | 6 | 9 | -0.2 | c1cc(CN2CCCNCCNCCCNCC2)nc(CN2CCCNCCNCCCNCC2)c1 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL278054 | 105526 | 1 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 503 | 4 | 6 | 9 | -0.2 | c1cc(CN2CCCNCCNCCCNCC2)nc(CN2CCCNCCNCCCNCC2)c1 | 10.1021/acs.jmedchem.6b01309 | ||
| 9892326 | 105513 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 503 | 4 | 6 | 9 | -0.2 | c1cc(CN2CCCNCCNCCCNCC2)cc(CN2CCCNCCNCCCNCC2)n1 | 10.1021/acs.jmedchem.6b01309 | ||
| CHEMBL277955 | 105513 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 503 | 4 | 6 | 9 | -0.2 | c1cc(CN2CCCNCCNCCCNCC2)cc(CN2CCCNCCNCCCNCC2)n1 | 10.1021/acs.jmedchem.6b01309 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 10.1074/jbc.m704739200 | ||
| 483559 | 188376 | 42 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| CHEMBL477121 | 188376 | 42 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 410 | 6 | 4 | 6 | 1.7 | c1ccc(CNCc2ccc(CN3CCCNCCNCCCNCC3)cc2)nc1 | 10.1074/jbc.m704739200 | ||
| 4410 | 9911 | 106 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| 65015 | 9911 | 106 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| 844 | 9911 | 106 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| DB06809 | 9911 | 106 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 16815309 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 16815309 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 16815309 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 16815309 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 16815309 | ||
| 13423 | 7945 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | Guide to Pharmacology | 339 | 3 | 0 | 4 | 2.7 | O=C(N1CCN(CC1)C2CCN(CC2)C3=CC=CC=C3)C4=CC=CO4 | 38863440 | ||
| 171061356 | 7945 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | Guide to Pharmacology | 339 | 3 | 0 | 4 | 2.7 | O=C(N1CCN(CC1)C2CCN(CC2)C3=CC=CC=C3)C4=CC=CO4 | 38863440 | ||
| 10146 | 8051 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | Guide to Pharmacology | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 30476826 | ||
| 137321154 | 8051 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | Guide to Pharmacology | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 30476826 | ||
| CHEMBL4596188 | 8051 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | Guide to Pharmacology | 404 | 7 | 1 | 2 | 6.0 | Clc1ccccc1CN1CCC(CC1)CNCc1cccc(c1)c1ccccc1 | 30476826 | ||
| 11256587 | 9240 | 59 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Guide to Pharmacology | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 20297846 | ||
| 8580 | 9240 | 59 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Guide to Pharmacology | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 20297846 | ||
| CHEMBL518924 | 9240 | 59 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Guide to Pharmacology | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 20297846 | ||
| DB05501 | 9240 | 59 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | Guide to Pharmacology | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 20297846 | ||
| 10679 | 9382 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | Guide to Pharmacology | None | None | None | None | 14649897 | ||||
| 91865076 | 9382 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | Guide to Pharmacology | None | None | None | None | 14649897 | ||||
| DB14939 | 9382 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | Guide to Pharmacology | None | None | None | None | 14649897 | ||||
| 4358 | 8023 | 0 | None | 35 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 30476826 | ||||
| 8534 | 8030 | 0 | None | - | 1 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | None | None | None | None | 21990345 | ||||
| 845 | 8024 | 0 | None | - | 1 | Human | 7.9 | pKd | = | 7.9 | Binding | Guide to Pharmacology | None | None | None | None | 9551924 | ||||
| 4358 | 8023 | 0 | None | 35 | 2 | Human | 8.0 | pKd | = | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 9551924 | ||||
| 4358 | 8023 | 0 | None | 35 | 2 | Human | 8.0 | pKd | = | 8.0 | Binding | Guide to Pharmacology | None | None | None | None | 9712844 | ||||
| 8536 | 10338 | 0 | None | - | 1 | Human | 8.1 | pKd | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 9384579 | ||||
| 8535 | 8029 | 0 | None | - | 1 | Human | 6.0 | pKd | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 21990345 | ||||
| None | 223198 | 0 | 125I-SDF-1 | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 673 | 10 | 9 | 8 | -1.2 | C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CCN)CC4=CC=C(C=C4)O | None | ||
| None | 223195 | 0 | 125I-SDF-1 | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 670 | 8 | 7 | 7 | -0.0 | C1CC2C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)N2C1)CC3=CC=C(C=C3)O)CC4=CC5=CC=CC=C5C=C4)CCCN=C(N)N | None | ||
| None | 223204 | 0 | 125I-SDF-1 | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 701 | 11 | 9 | 8 | -1.3 | C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CCC(=O)N)CC4=CC=C(C=C4)O | None | ||
| None | 223199 | 0 | 125I-SDF-1 | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 687 | 11 | 9 | 8 | -0.8 | C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CCCN)CC4=CC=C(C=C4)O | None | ||
| None | 223196 | 0 | 125I-SDF-1 | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 644 | 8 | 8 | 7 | -0.5 | CC1C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N | None | ||
| None | 223201 | 0 | 125I-SDF-1 | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 715 | 11 | 10 | 8 | -1.9 | C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CCN=C(N)N)CC4=CC=C(C=C4)O | None | ||
| None | 223203 | 0 | 125I-SDF-1 | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 687 | 10 | 9 | 8 | -1.7 | C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CC(=O)N)CC4=CC=C(C=C4)O | None | ||
| None | 223202 | 0 | 125I-SDF-1 | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 743 | 13 | 10 | 8 | -1.1 | C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CCCCN=C(N)N)CC4=CC=C(C=C4)O | None | ||
| None | 223197 | 0 | 125I-SDF-1 | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 658 | 8 | 7 | 7 | -0.2 | CC1C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)N1C)CC2=CC=C(C=C2)O)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N | None | ||
| None | 223195 | 0 | 125I-SDF-1 | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 670 | 8 | 7 | 7 | -0.0 | C1CC2C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)N2C1)CC3=CC=C(C=C3)O)CC4=CC5=CC=CC=C5C=C4)CCCN=C(N)N | None | ||
| None | 223197 | 0 | 125I-SDF-1 | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 658 | 8 | 7 | 7 | -0.2 | CC1C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)N1C)CC2=CC=C(C=C2)O)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N | None | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | None | ||
| None | 223205 | 0 | 125I-SDF-1 | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 702 | 11 | 9 | 8 | -0.7 | C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CCC(=O)O)CC4=CC=C(C=C4)O | None | ||
| None | 223196 | 0 | 125I-SDF-1 | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 644 | 8 | 8 | 7 | -0.5 | CC1C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)CC3=CC4=CC=CC=C4C=C3)CCCN=C(N)N | None | ||
| None | 223206 | 0 | 125I-SDF-1 | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 727 | 9 | 9 | 8 | -1.8 | C1C(CN2C1C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C2=O)CC3=CC=C(C=C3)O)CC4=CC5=CC=CC=C5C=C4)CCCN=C(N)N)N=C(N)N | None | ||
| None | 223200 | 0 | 125I-SDF-1 | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 701 | 12 | 9 | 8 | -0.4 | C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC3=CC=CC=C3C=C2)CCCN=C(N)N)CCCCN)CC4=CC=C(C=C4)O | None | ||
| 11256587 | 9240 | 59 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 18768385 | ||
| 8580 | 9240 | 59 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 18768385 | ||
| CHEMBL518924 | 9240 | 59 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 18768385 | ||
| DB05501 | 9240 | 59 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 349 | 7 | 2 | 4 | 3.6 | NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2 | 18768385 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 30476826 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 30476826 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 30476826 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 30476826 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 30476826 | ||
| 4410 | 9911 | 106 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 11923301 | ||
| 65015 | 9911 | 106 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 11923301 | ||
| 844 | 9911 | 106 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 11923301 | ||
| CHEMBL18442 | 9911 | 106 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 11923301 | ||
| DB06809 | 9911 | 106 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | Guide to Pharmacology | 502 | 4 | 6 | 8 | 0.4 | C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1 | 11923301 | ||
| 5273315 | 8021 | 0 | None | - | 1 | Human | 4.9 | pKi | None | 4.9 | Binding | Guide to Pharmacology | None | None | None | None | 9712844 | ||||
| 847 | 8021 | 0 | None | - | 1 | Human | 4.9 | pKi | None | 4.9 | Binding | Guide to Pharmacology | None | None | None | None | 9712844 | ||||
| 851 | 10337 | 0 | None | - | 1 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | None | None | None | None | 9712844 | ||||
| 155817384 | 8020 | 0 | None | - | 1 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | None | None | None | None | 9712844 | ||||
| 16133599 | 8020 | 0 | None | - | 1 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | None | None | None | None | 9712844 | ||||
| 846 | 8020 | 0 | None | - | 1 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | None | None | None | None | 9712844 | ||||
| 848 | 8022 | 0 | None | - | 1 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | None | None | None | None | 9712844 | ||||